This page is updated frequently with new Elan-related patent applications.
| Biocampatible polymer coated silver prussian blue nanoparticles (spb-nps: ag3 [fe (cn) 6])|
The present invention relates to highly biocompatible or nontoxic pvp (poly(n-vinyl-2-pyrrolidone) coated silver prussian blue nanoparticles (spb-nps: ag3[fe(cn)6] where pvp acts as stabilizing or capping agent. The as-synthesized nanoparticles (spb-nps) have been thoroughly characterized by several analytical tools.
Council Of Scientific & Industrial Research
| Skin lightening composition|
Desired skin colour is a major unmet consumer need around the world and especially in asia. Consumers particularly desire even skin colour, absence of age spots (solar lentigines), absence of hyperpigmentation and lighter overall skin tone.
Conopco, Inc., D/b/a Unilever
|Graphical user interface with intelligent icons|
A system for signaling coordinated workers in a common goal through intelligent icons transferred across networks to computer screens. The system can comprise one or more electronic data processors.
|Histamine-3 receptor antagonists|
The invention is directed to a compound of formula i, as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula i; and a method of treatment of a disorder or condition selected from the list consisting of acute myocardial infarction; memory processes disorders; dementia; cognition disorders such as alzheimer's disease; attention deficit disorder (add); attention-deficit hyperactivity disorder (adhd); cancers such as cutaneous carcinoma, medullary thyroid carcinoma and melanoma; meniere's disease; gastrointestinal disorders; inflammation; migraine; motion sickness; obesity; pain; septic shock; respiratory disorders (including allergic rhinitis, nasal congestion and allergic congestion) in a mammal, including a human, that may be effected by administering to said mammal a pharmacologically effective amount of a compound of formula i, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.. .
|Method for making anion exchange and chelant resins including aliphatic amino functional groups|
A method for making an anion exchange or chelant resin comprising a vinyl aromatic polymer including a repeating unit comprising an aromatic ring substituted with an aliphatic amino group, wherein the method comprises the step of reacting a vinyl aromatic polymer with a nitro compound comprising from 1 to 12 carbon atoms with the proviso that the a carbon includes at least one hydrogen.. .
Dow Global Technologies Llc
|Methods of inducing melanogenesis in a subject|
Described herein are methods and compositions for inducing melanogenesis in a human subject. The method comprises administering to a subject an alpha-msh analogue, in an effective amount and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without inducing homologous desensitization of the melanocortin-1 receptors..
Clinuvel Pharmaceuticals Limited
|Stem cell microparticles and mirna|
This invention relates to stem cell microparticles and mirna isolated from these microparticles, their use and production thereof, in particular neural stem cell microparticles and their use in therapy of cancer, typically a nestin-positive cancer. The cancer may be glioma, melanoma, breast cancer, pancreatic cancer or prostate cancer.
|Melanin binding agents for targeted topical delivery|
Compositions and methods are disclosed for targeted delivery of a benefit agent to areas of a human integument having melanin deposits. The compositions comprise a pyridinium compound having affinity for melanin.
Avon Products, Inc
|Low ph metal-free preparation of aminated organic acid|
Where r1, r1a, r2, r2a, r3 and r3a are defined as set forth in the specification. Formula i compounds are useful as chelants and stabilizers of cations in aqueous media and the invention therefore provides a method for using the compounds in the treatment of subterranean formations, such as in acidizing operations..
|Treatment of melanoma with interferon-beta and ras-raf-mek-erk inhibitor combination therapy|
This description relates to the use of a polymer-conjugated interferon-beta as monotherapy or in combination with other cancer therapies.. .
Biogen Ma Inc.
Method for improving skin condition or anti-microorganisms or anti-oxidation using lactobacillus sakei md honeysuckle
The present disclosure discloses a method for improving the skin condition or anti-microorganisms or anti-oxidation using lactobacillus sakei md_honeysuckle (accession number: kctc 12675bp) derived from lonicera japonica thunb. A composition containing the strain or a cultured product thereof, or an extract thereof as an active ingredient has superior dpph radical scavenging activity and antimicrobial activity against pathogenic microorganisms, has a high total polyphenol content and is capable of inhibiting the growth of melanocytes.
Rock in combination with mapk pathway
The current disclosure relates to pharmaceutical combinations and compositions useful in the treatment of certain types of cancer. The disclosure also relates to method of treatment these certain types of cancer.
Stichting Het Nederlands Kanker Instituut
Methods of treating melanoma
Provided herein are methods for the treatment of melanoma comprising administration of a composition comprising nanoparticles comprising taxane and a carrier protein.. .
Abraxis Bioscience, Llc
Method of quantifying melanin mass density in vivo
A method of quantifying melanin includes receiving at a data processor optical data produced by an optical sensor which receives a light from a tissue; determining a set of intensity values based on the optical data; for each intensity value, converting the intensity value to a quantifying value corresponding to quantity of melanin in the tissue based on a two-dimensional non-linear regression with one variable representing the intensity value and another variable representing the quantity of melanin; collecting at the data processor each quantifying value; generating at the data processor melanin quantity distribution data according to the quantifying values; and outputting the melanin quantity distribution data to be presented on a medium.. .
National Taiwan University
Activities of multiple cancer-related pathways are associated with braf mutation and predict the resistance to braf/mek inhibitors in melanoma cells
The present inventors have identified specific oncogenic pathways preferentially activated in braf-mutated-melanoma cells and a pathway pattern that predicts resistance of braf-mutated melanoma to braf/mek inhibitors, providing novel clinical implications for melanoma therapy. In one embodiment, a method comprises (a) testing a sample oibraf-mutated melanoma cells isolated from a patient and measuring the expression levels of genes expressed in the following oncogenic pathways: tnfa, egfr, ifna, hypoxia, ifny, stat3 and myc; (b) calculating a 7-pathway activation pattern based on the measured expression levels of step (a); and (c) identifying the patient's resistance level to braf/mek inhibitor treatment based on comparison of the calculated 7-pathway activation pattern to a reference..
The Johns Hopkins University
Method for enucleating nucleated erythrocyte, and enucleation inducer
Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided are a method of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time by adding a compound derived from proopiomelanocortin (pomc) to an undifferentiated (nucleated) erythrocyte, and an enucleation inducer including the compound..
Kanazawa Medical University
Antibodies specific for claudin 6 (cldn6)
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing claudin-6 (cldn6), including tumor-related diseases such as ovarian cancer, lung cancer, gastric cancer, breast cancer, hepatic cancer, pancreatic cancer, skin cancer, malignant melanoma, head and neck cancer, sarcoma, bile duct cancer, cancer of the urinary bladder, kidney cancer, colon cancer, placental choriocarcinoma, cervical cancer, testicular cancer, and uterine cancer.. .
Johannes Gutenberg-universitat Mainz
Epidithiodioxopiperazine compound or its derivatives, and the use thereof
The present invention relates to an epidithiodioxopiperazine derivative represented by the following chemical formula 1 or its reduced derivative; a method for preparing a compound represented by chemical formula 1 having improved intracellular permeability and mimicking the activity of 2-cys-prx in its reduced form in the cells; a pharmaceutical composition for preventing or treating vascular diseases comprising an epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient; a drug delivery device for local administration including the pharmaceutical composition; and a pharmaceutical composition for inhibiting melanoma metastasis comprising the epidithiodioxopiperazine compound or its derivatives or pharmaceutically acceptable salts thereof as an active ingredient.. .
Ewha University-industry Collaboration Foundation
Cosmetic or dermatological use of an extract of tapirira guianensis
Finally, it relates to a tapirira guianensis extract or a dermatological composition comprising a tapirira guianensis extract and a dermatologically acceptable excipient for use by the topical route in the treatment and/or prevention of rosacea, telangiectasia and/or pathologies of the oral and/or ocular mucous membranes.. .
E2f reporter melanoma cells
A modified melanoma cell line capable of quantification of the effects of mek inhibitors and cdk4/6 inhibitors in a quantitative, temporal and non-invasive manner both in vitro and in vivo.. .
Thomas Jefferson University
Method for preparing pluripotent stem cells
An object of the present invention is to provide a method capable of inexpensively and conveniently preparing cells having pluripotency and a very low risk of tumorigenic transformation. The cells having pluripotency and a very low risk of tumorigenic transformation can be prepared by suspension-culturing mammalian mesenchymal stem cells such as human mesenchymal stem cells from bone marrow (hmsc-bm) and human adipose tissue-derived mesenchymal stem cells (hat-msc) (also referred to as “human adipose-derived stem cells [hadsc]”), 7 types of human adherent mature cells (human hepatocyte cells [hhep cells], human umbilical vein endothelial cells [huvec cells], human dermal lymphatic microvascular endothelial cells [hmvec cells], human epidermal keratinocyte cells [nhek cells], human bronchial epithelial cells [nhbe cells], human melanocyte cells [nhem cells], and human smooth muscle cells [uasmc cells]), and 3 types of human adherent precursor cells (human dermal fibroblast cells [nhdf cells], human skeletal muscle myoblast cells [hsmm cells], and human osteoblast cells [nhost cells]) to form cell masses (spheroids)..
Otsuka Pharmaceutical Factory, Inc.
Multimeric il-15 soluble fusion molecules and methods of making and using same
The present invention features compositions and methods featuring alt-803, a complex of an interleukin-15 (il-15) superagonist mutant and a dimeric il-15 receptor α/fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus).. .
Altor Bioscience Corporation
Optical imaging or spectroscopy systems and methods
Optical imaging or spectroscopy described can use laminar optical tomography (lot), diffuse correlation spectroscopy (dcs), or the like. An incident beam is scanned across a target.
The Trustees Of Columbia University In The City Of New York
Systems and methods for crowdsourcing technology projects
The technology introduced here enables a customer to readily view, and securely connect with, project managers and freelancers who complete projects on behalf of the customer. The customer initially posts a project specification through a crowdsourcing platform.
Antibodies to endoplasmin and their use
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human.
University Of Pittsburgh - Of The Commonwealth Sys Tem Of Higher Education
Heteroaryl amides as inhibitors of protein aggregation
The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as parkinson's disease, alzheimer's disease, lewy body disease, parkinson's disease with dementia, fronto-temporal dementia, huntington's disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.. .
Neuropore Therapies, Inc.
Method of obtaining or maintaining optical transmittance into boiler liquid
A clean-in-place method of maintaining optical transference through a light transference medium operably connected to a boiler system is disclosed. The method comprises inter alia contacting a liquid chemical agent to a wetted surface of a light transference medium.
Ecolab Usa Inc.
Method of nociceptor differentiation of human embryonic stem cells and uses thereof
The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hesc), human induced pluripotent stem cells (hipsc), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hesc and/or hipsc to nociceptors (i.e.
Memorial Sloan Kettering Cancer Center
Virus like particle comprising modified envelope protein e3
A virus like particle comprising a viral structural protein which comprises modified envelope protein e3. The viral structural protein may be that derived from or alphavirus or flavivirus.
Vlp Therapeutics, Llc
Inhibition of thymine dna glycosylase in the treatment of cancer
The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine dna glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine dna glycosylase in cancer cells.
Institut De Génétique Et De Biologie Moléculaire Et Cellulaire
Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds.
Celgene Quanticel Research, Inc.
Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.
Histone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Celgene Quanticel Research, Inc.
Triazolone compounds and uses thereof
The invention disclosed herein is directed to compounds of formula (1a) and (1b) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocyticδ leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula (1a) or (1b), or a pharmaceutically acceptable salt thereof.
Inception 2, Inc.
Liposomal curcumin for treatment of cancer
The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system.
Board Of Regents, The University Of Texas System
Diarylalkanes as potent inhibitors of binuclear enzymes
The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction.
Monoclonal antibodies for treatment of cancer
The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing gt468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung..
Selective histone deactylase 6 inhibitors
Disclosed are selective histone deactylase inhibitors (hdaci) that having formula i. Specifically, the disclosed subject matter relates to compounds having activity as selective hdac6 inhibitors, methods of making and using the compounds, and compositions comprising the compounds.
Compounds from antrodia camphorata, preparing the same and use thereof
The invention relates to bioactive compounds purified from mycelium of antrodia camphorata and the manufacturing method thereof. A method for treatment of cancers by administrating an effective amount of the said compounds selected from the group consisting of ac006, ac007, ac009, ac011, ac012, ac007-h1, ac009-h1, and ac012-h1 wherein the cancers is liver cancer, brain cancer, prostate cancer, breast cancer, colorectal cancer, or melanoma..
Herbal combinations for treatment of a skin condition
A method and medicine for treating melanoma, bcc (basal cell carcinoma) or psoriasis or other inflammatory skin disease, or a combination thereof, comprising applying or injecting to an infected skin area of a patient diagnosed with melanoma, bcc (basal cell carcinoma) or psoriasis or other inflammatory skin disease, or a combination thereof, a treatment regimen that includes periodic doses of a molecular combination of emodin and digoxin and/or an herbal combination of da huang and sheng di huang.. .
Systems and methods for crowdfunding and crowdsourcing a project
A system and method for crowdfunding and crowdsourcing a project that receives, via communication circuitry, a project from a user, determines, using processing circuitry, whether the project adheres to a predetermined criteria, provides the project to a crowdsourcing community and a crowdfunding community, receives bids from one or more freelancers to implement one or more parts of the project, receives contributions from one or more contributors, selects at least one freelancer based on a predefined rule, determines a total amount of contributions, determines a total amount of funds needed, determines whether the total amount of contributions is at least equal to the total amount of funds needed, assigns the one or more parts of the project to the selected at least one freelancer, transmits an alert to at least on device associated with the selected at least one freelancer, and submits payments to the selected at least one freelancer.. .
Method of automatic dishwashing
A method of cleaning a dishwashing load comprising dishware and tableware having bleachable stains in the presence of iron in a dishwasher, the method comprising the step of contacting the ware with a detergent composition comprising an iron chelant wherein the detergent composition is free or substantially free of bleach and preferably has a ph as measured in 1% weight aqueous solution at 25° c. Of from about 5 to about 7.5.
A substantially builder-free low-ph automatic dishwashing detergent composition comprising a buffer, an enzyme and an iron chelant and wherein the composition has a ph as measured in 1% weight aqueous solution at 25° c. Of from about 5 to about 7.5..
Melanocortin receptor ligands modified with hydantoin
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.. .
Drug containing recombinant mistletoe lectins for treating malignant melanoma
The invention relates to a drug and/or pharmaceutical composition for treating metastatic tumors, in particular of malignant melanoma, above all of stage iv malignant melanoma, and to the use of said drug, in particular the use of said drug in select patient populations.. .
Melanotropin ligands for skin care
A melanocortin 1 receptor (mc1r) peptide ligand-elastic vesicle complex. The mc1r peptide ligand is modified by coupling the mc1r ligand to a functionality or linker, such as a click functionality, for conjugation to a surface or agent.
Method of inhibiting copper deposition on hair
A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a bleaching or oxidative dyeing composition comprising a chelant, rinsing the bleaching or oxidative dyeing composition, applying to the hair a rinse-off conditioner composition comprising histidine, rinsing the rinse-off conditioner composition from the hair, applying to the hair a shampoo composition having ethylenediamine-n,n′-disuccinic acid and/or histidine, rinsing the shampoo composition from the hair, applying to the hair a rinse-off conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.. .
Electronic vapor liquid composition and use
An e-liquid for use in electronic cigarettes which utilizes a vaporizing base (either propylene glycol, vegetable glycerin, or mixture of the two) mixed with an herbal powder extract generally at a 0.001 g-2.0 g per 1 ml ratio. The herbal extract can be any of the following: kanna (sceletium tortuosum), blue lotus (nymphaea caerulea), salvia (salvia divinorum), salvia eivinorm, kratom (mitragyna speciosa), celandine poppy (stylophorum diphyllum), mugwort (artemisia), coltsfoot leaf (tussilago farfara), california poppy (eschscholzia californica), sinicuichi (heimia salicifolia), st.
Method for reduction of flying insects in livestock feeds and feed supplements
Methods for reducing flying insects from animal feeds or animal feed supplements involve, in a location accessible to flying insects, providing a livestock animal with an animal feed or a liquid supplement and a palatant or a molasses replacement in an amount effective to reduce flying insects from occupying an area on and around the animal feed or the liquid supplement. The palatant or the hydrolyzed whey within the palatant may account for at least about 2 percent of the animal feed or liquid supplement by weight.
Composition and vaccine for treating lung cancer
The present invention relates to a composition comprising at least one mrna encoding a combination of antigens capable of eliciting an (adaptive) immune response in a mammal, wherein the antigens are selected from the group consisting of 5t4 (trophoblast glycoprotein, tpbg), survivin (baculoviral tap repeat-containing protein 5; birc5), ny-eso-1 (new york esophageal squamous cell carcinoma 1, ctag1b), mage-c1 (melanoma antigen family c1), mage-c2 (melanoma antigen family c2), and muc1 (mucin 1). The invention furthermore relates to a vaccine comprising at least one mrna encoding such a combination of antigens, and to the use of said composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, preferably of non-small cell lung cancer (nsclc), and diseases or disorders related thereto.
A compound represented by general formula (i) has a strong axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.. .
Ono Pharmaceutical Co., Ltd.
System and optical detection of skin disease
An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.. .
The Rockefeller University
Synergistic herbicidal composition containing penoxsulam, triclopyr and bispyribac
Methods for controlling weeds using synergistic compositions containing penoxsulam, triclopyr, and bispyribac, especially rice, sugarcane, cereal and grain crops, pastures, rangelands, industrial vegetation management (ivm), aquatics and turf, as well as protecting crops from herbicidal injury caused by any of the individual components. These methods provide improved post-emergence herbicidal weed control and reduce herbicidal injury by concomitant application of the mixture..
Dow Agrosciences Llc
Method and system for optimizing accuracy-specificity trade-offs in large scale visual recognition
As visual recognition scales up to ever larger numbers of categories, maintaining high accuracy is increasingly difficult. Embodiment of the present invention include methods for optimizing accuracy-specificity trade-offs in large scale recognition where object categories form a semantic hierarchy consisting of many levels of abstraction..
The Board Of Trustees Of The Leland Stanford Junior University
Sensing platform for quantum transduction of chemical information
A system for determining chemistry of a molecule in a high background interfering liquid environment by application of an electronic signal at a biased metal-electrolyte interface is disclosed. One or more of a resonant exchange of energy between one or more electrons exchanged by the metal and the electrolyte and vibrating bonds of a molecular analyte, for example, may be sensed by measuring small signal conductivity of an electrochemical interface..
The Board Of Trustees Of The Leland Stanford Junior University
Capillary barriers for staged loading of microfluidic devices
Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure.
The Board Of Trustees Of The Leland Stanford Junior University
Hydrogen Production From Water
Female Sexual Dysfunction
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