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Elan

Elan-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Specific combined therapy of malignant tumors with a cytostatic and its modifier
October 12, 2017 - N°20170290882

Technical result of the alleged invention, which increases efficiency while treating malignant hematological diseases or melanoma, involves synergistic effect during the combined impact of a cytostatic and its immune modifier; this effect allows reduction of therapeutic dose of highly toxic cytostatics without reducing their anti-tumor effect. 1 independent claim, 3 dependent claims, 4 examples, 4 tables
Encapsulated cleaning composition
Basf Se
October 05, 2017 - N°20170283748

An encapsulated cleaning composition includes a core cleaning composition and a water-soluble film disposed about the core cleaning composition. The core cleaning composition itself includes an ionic liquid, water present in an amount of from 10 to 50 parts by weight per 100 parts by weight of the core cleaning composition, and at least one of a chelant, an enzyme, and a surfactant. ...
Antibodies, pharmaceutical compositions and methods
Obi Pharma, Inc.
October 05, 2017 - N°20170283488

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (ssea-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics. The antibodies of the disclosure can bind to certain cancer cell surfaces. Exemplary targets of the antibodies disclosed herein can include carcinomas, such as ...
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Methods of producing ganoderma lucidum mycelia having enhanced ganodermanondiol content
Ami Cosmetic Co., Ltd.
October 05, 2017 - N°20170280629

Provided is a method of culturing ganoderma lucidum mycelia in which the content of ganodermanondiol serving as an inhibitor to melanin biosynthesis is enhanced to improve skin whitening function.
Treatment and detection of melanoma
The Council Of The Queensland Institute Of Medical Research
September 28, 2017 - N°20170275703

Provided are methods for determining or predicting the diagnosis, prognosis, treatment and therapeutic efficacy of melanoma in a subject, which include evaluating the expression level of one or more mirna biomarkers including mirna-4487, mirna-4706, mirna-4731 and fragments or variants thereof as an indication of whether the subject may have, or be predisposed to, melanoma.
Methods and materials for identifying metastatic malignant skin lesions and treating skin cancer
Mayo Foundation For Medical Education And Research
September 28, 2017 - N°20170275700

This document provides methods and materials for identifying metastatic malignant skin lesions (e. G., malignant pigmented skin lesions). For example, methods and materials for using quantitative pcr results and correction protocols to reduce the impact of basal keratinocyte contamination on the analysis of test sample results to identify metastatic malignant skin lesions are provided. This document also provides methods and ...
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N-pyridinyl acetamide derivatives as inhibitors of the wnt signaling pathway
Redx Pharma Plc
September 28, 2017 - N°20170275276

Disclosed are compounds useful as inhibitors of the wnt signalling pathway. Specifically, inhibitors of porcupine (porcn) are contemplated by the invention. In addition, the invention contemplates processes to prepare the compounds and uses of the compounds. The compounds of the invention may therefore be used in treating conditions mediated by the wnt signalling pathway, for example, in treating cancer, sarcoma, ...
Histone demethylase inhibitors
Celgene Quanticel Research, Inc.
September 28, 2017 - N°20170275266

Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase. Furthermore, the subject compounds and compositions are useful for the treatment of cancer, such as prostate cancer, breast cancer, bladder cancer, lung cancer and/or melanoma and the like.
Series of skin whitening (lightening) compounds
Unigen, Inc.
September 28, 2017 - N°20170275224

The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
Pharmaceutical compositions and methods
Tyme, Inc.
September 28, 2017 - N°20170274051

Pharmaceutical compositions and kits including a tyrosine hydroxylase inhibitor; melanin, a melanin promoter, or a combination thereof a p450 3a4 promoter; and a leucine aminopeptidase inhibitor are provided. Also provided are methods of treating cancer in a subject, comprising administering an effective amount of a tyrosine hydroxylase inhibitor, a melanin promoter, a p450 3a4 promoter, and a leucine aminopeptidase inhibitor ...
Peptide having activity to improve skin condition and use thereof
Caregen Co., Ltd.
September 21, 2017 - N°20170267721

The present invention provides a peptide having activity to improve skin condition. The peptide of the present invention exhibits a very excellent effect in improving skin condition by inhibiting mmp2 activity. A composition containing the peptide of the present invention exhibits excellent biological activities, such as inhibiting collagen decomposition and melanosome migration, and thus can be used in wrinkle reduction, ...
Natural and synthetic compounds for treating cancer and other diseases
Pacific Arrow Limited
September 21, 2017 - N°20170267714

This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or ...
Composition for altering the color of keratin fibers
L'oreal
September 21, 2017 - N°20170266104

Disclosed herein are compositions and methods for altering the color of hair comprising a first mixture comprising from about 1% to about 50% of at least one starch, from about 1% to about 50% of at least one liquid fatty substance and from about 0. 5% to about 40% of at least one silica material, and a second mixture comprising from about 1% to about 40% of at least ...
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Malassezin and analogs thereof as skin brightening agents
Quest Diagnostics Investments Incorporated
September 14, 2017 - N°20170260133

The present invention relates to compounds, compositions, and methods for brightening skin. The compounds, compositions, and methods of the present invention generally involve compounds produced by a malassezia yeast, and chemical analogs thereof. In addition to skin brightening applications, the compounds, compositions, and methods of the present invention may be used to modulate melanocyte activity, induce melanocyte apoptosis, agonize an ...
Stable peptide-conjugated ascorbic acid derivative, method for preparing same, and cosmetic composition comprising same
Celltrion Inc.
September 14, 2017 - N°20170258931

The present invention provides a stable peptide-conjugated, ascorbic acid derivative, a method for preparing the same, and a cosmetic composition comprising the same as an active ingredient. The stable peptide-conjugated ascorbic acid derivative of the present invention has both the effect of whitening the skin by inhibiting melanin production and the effect of reducing skin wrinkles by activating collagen production, ...
Pkc delta inhibitors for use as therapeutics
Faller & Williams Technology, Llc
September 07, 2017 - N°20170252322

The invention is directed to compounds that are specific inhibitors of pkc delta, and methods and compositions for the treatment and prevention of cancers and other disorders. Compositions comprising compounds of the invention are used to treat cancers such as, for example, carcinoid and neuroendocrine tumors, malignant melanomas, pancreatic, gastrointestinal and lung cancers. Neuroendocrine tumor cell lines of pulmonary and ...
Mixed spheroids of melanocytes and keratinocytes
Centre National De La Recherche Scientifique
August 31, 2017 - N°20170248582

The present invention concerns the development of a model to evaluate active substances targeting the epidermis. It more particularly relates to the preparation of mixed spheroids of melanocytes and keratinocytes reproducing cell interactions occurring in the epidermis, to the spheroids as such and to the uses thereof.
Inferring service providers
Linkedin Corporation
August 24, 2017 - N°20170243271

A system and method for inferring service providers are provided. In example embodiments, member data of members of a social networking service is accessed. From the member data, it is inferred that a particular member among the members of the social networking service is a freelancer member. A service request that the freelancer member is capable of fulfilling is identified ...
Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
The Board Of Regents Of The University Of Texas System
August 24, 2017 - N°20170240919

The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to western equine encephalitis virus, eastern equine encephalitis virus, venezuelan equine encephalitis virus or chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their ...
Solvent application in bottle wash using amidine based formulas
Ecolab Usa Inc.
August 24, 2017 - N°20170240846

According to the invention, the compositions and methods provide for the complete removal of labels, synthetic glues and/or adhesives from a plurality of surfaces through the use of an aqueous or non-aqueous basic organic solvent and/or an amidine, optionally in combination with surfactants, chelants, acidulants and/or additional bottle wash additives. Beneficially, the compositions and methods are suitable ...
Melanocortin receptor ligands
Ecolab Usa Inc.
August 24, 2017 - N°20170240595

And pharmaceutically-acceptable salts thereof that act as ligands for one or more of the melanocortin receptors, to methods of using such compounds to treat mammals and to pharmaceutical compositions comprising said compounds.
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