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Elan patents



      
           
This page is updated frequently with new Elan-related patent applications.



Date/App# patent app List of recent Elan-related patents
02/04/16
20160036375 
 Transportable hybrid power system patent thumbnailnew patent Transportable hybrid power system
A transportable, deployable power system comprising a hybrid power box containing solar panels, wind turbine(s), fuel cells, fuel reformers, and other energy sources. The system could also include waste water and potable water inlet and outlet ports for water treatment.

02/04/16
20160030532 
 Erythrocytes containing arginine deiminase patent thumbnailnew patent Erythrocytes containing arginine deiminase
Use of erythrocytes containing arginine deirainase for the preparation of a medicinal product for lowering the plasma concentration of arginine in vivo. The use relates in particular to the treatment of arginine-dependent tumors, such as hepatocarcinoma and malignant melanoma, or inhibition of the synthesis of nitric oxide, and the prevention and/or treatment of septic shock..
Erytech Pharma


02/04/16
20160030325 
 Method and compositions for treating dermal papilla cells associated with keratin fibers patent thumbnailnew patent Method and compositions for treating dermal papilla cells associated with keratin fibers
A composition for topical application to dermal papilla cells associated with keratin fibers from scalp, eyelashes or eyebrows comprising at least one ogg1 dna repair enzyme, and method for treating dermal papilla cells associated with keratin fibers to inhibit oxidative damage, stimulate melanin synthesis, and reduce apoptosis.. .
Elc Management Llc


01/28/16
20160024595 
 Characterization of melanoma using a molecular signature patent thumbnailCharacterization of melanoma using a molecular signature
The present disclosure provides methods for characterizing melanoma in a subject by analyzing genes or gene expression products obtained from the subject. The present disclosure provides methods for distinguishing melanoma in situ from invasive melanoma.
Dermtech International


01/28/16
20160024515 
 Modulation of flavonoid content in cacao plants patent thumbnailModulation of flavonoid content in cacao plants
Methods and materials for modulating (e.g., increasing or decreasing) flavonoid levels in cacao plants are disclosed. For example, nucleic acids encoding flavonoid-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells.
Cacao Bio-technologies, Llc


01/28/16
20160024045 
 Chiral compounds, compositions, products and methods employing same patent thumbnailChiral compounds, compositions, products and methods employing same
Compounds that function, alone or in combination, as inhibitors of pigmentation for the improvement of mammalian skin are described herein. Specifically, the compounds of the present disclosure, namely chiral, non-racemic compounds, function as pigment formation inhibitors thereof to beautify skin and discourage the production of melanins.
Merz North America, Inc.


01/28/16
20160022648 
 Therapeutic agent for meibomian gland dysfunction patent thumbnailTherapeutic agent for meibomian gland dysfunction
Or a pharmaceutically acceptable salt thereof can reduce a score of telangiectasia around the meibomian gland orifices and a number of obstruction at the orifices, so that it is useful as a prophylactic and/or therapeutic agent for meibomian gland dysfunction.. .

01/21/16
20160018742 
 Method of measuring overlay error and a device manufacturing method patent thumbnailMethod of measuring overlay error and a device manufacturing method
The overlay error of a target in a scribelane is measured. The overlay error of the required feature in the chip area may differ from this due to, for example, different responses to the exposure process.
Asml Netherlands B.v.


01/21/16
20160015971 
 Nanosecond pulsed electric fields cause melanomas to self-destruct patent thumbnailNanosecond pulsed electric fields cause melanomas to self-destruct
Methods for a new, drug-free therapy for treating solid skin tumors through the application of nanosecond pulsed electric fields (“nspefs”) are provided. In one embodiment of the invention, the cells are melanoma cells, and the applied nspefs penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop.
Old Dominion University Research Foundation


01/21/16
20160015688 
 Compounds for treatment of cancer patent thumbnailCompounds for treatment of cancer
The present invention relates to pharmaceutical compositions for treating cancer comprising braf inhibitors, (e.g. Vemurafenib) and/or mek inhibitor, (e.g.
University Of Tennessee Research Foundation


01/14/16
20160010089 

Organic compositions to treat epasi-related diseases


The present disclosure relates to methods of treating epas1-related diseases such as cancer, metastases, astrocytoma, bladder cancer, breast cancer, chondrosarcoma, colorectal carcinoma, gastric carcinoma, glioblastoma, head and neck squamous cell carcinoma, hepatocellular carcinoma, lung adenocarcinoma, neuroblastoma, non-small cell lung cancer, melanoma, multiple myeloma, ovarian cancer, rectal cancer, renal cancer, clear cell renal cell carcinoma (and metastases of this and other cancers), gingivitis, psoriasis, kaposi's sarcoma-associated herpesvirus, preemclampsia, inflammation, chronic inflammation, neovascular diseases, and rheumatoid arthritis, using a therapeutically effective amount of a rnai agent to epas1.. .
Arrowhead Research Corporation


01/14/16
20160010088 

Method for inhibiting tumor growth through rna-interference using liposomally associated cdc20 sirna


Liposomal compositions comprising of liposomes of guanidinylated cationic amphiphiles as the main lipid and cholesterol/1,2-dioleoyl-sn-glycero-3-phosphocholine (dopc)/aminopropyl polyethyleneglycol carbamyl-distearoylphosphatidyl-ethanolamine (dspe-peg-nh2) as co-lipids are described. These liposomal compositions containing encapsulated or electrostatically complexed therapeutic small interfering rnas (sirnas) against cdc20, a key cell cycle regulator, inhibit solid tumor growth and melanoma tumor growth on lung in c57bl/6j mice..
Council Of Scientific & Industrial Research


01/14/16
20160010068 

Fusion polynucleotides and fusion polypeptides associated with cancer and particularly melanoma and their uses as therapeutic and diagnostic targets


Novel fusion molecules and uses are disclosed.. .

01/14/16
20160009804 

Therapeutic and diagnostic methods relating to cancer stem cells


The present invention relates in part to the discovery of genes that are deregulated in cancer stem cells (e.g., melanoma stem cells). In some aspects, methods for treating individuals having melanoma are provided; the methods involve modulating (e.g., inducing, inhibiting, etc.) the activity of the cancer stem cell associated genes.
The Brigham And Women's Hospital, Inc.


01/14/16
20160009652 

Small-molecule modulators of melanin expression


The present invention relates to small molecule modulators of melanin expression and methods of making the small molecules. Also disclosed are methods of increasing pigmentation in a cell which involve providing compounds of the present invention and contacting a cell with the compounds under conditions effective to induce melanin expression in the cell, thereby increasing pigmentation.
University Of Rochester


01/14/16
20160008347 

Therapeutic uses of nicotine


The use of nicotine for treating inflammatory pain and hyphema is described. It is believed that inflammatory pain, such as renal pain, and hyphema can be improved by the various diseases, disorders or conditions can be improved by increasing the activity of α-melanocyte stimulating hormone (α-msh), whose release is affected by nicotine..

01/14/16
20160008332 

Combinatorial compositions and methods for treatment of melanoma


Embodiments described here are combinatorial compositions and methods using these compositions for treating melanomas having activated mutations. The compositions comprises combinations of inhibitors of a mapk pathway, erk inhibitors, egfr inhibitors, oxidative phosphorylation (oxphos) inhibitors, inhibitors of b-raf, mitochondrial inhibitors, c-kit inhibitors, mek inhibitors and tigecycline or a derivative thereof..
The General Hospital Corporation


01/14/16
20160008295 

Compositions and methods for treating rosacea


The present invention relates to terpine-4-ol containing pharmaceutical compositions, dermatological delivery systems and methods of treatment that are useful for treating rosacea, to include ocular rosacea, papulopustular rosacea, phymatous rosacea, acne rosacea, rosacea associated with demodex infections, erythematelangiectatic rosacea, steroid induced rosacea, and combinations thereof, acne vulgaris and related conditions in a patient in need thereof.. .
Tissuetech, Inc.


01/14/16
20160007907 

Diagnostic methods and device


The present invention relates to a method of diagnosing, or providing a prognosis to, or for providing the likelihood of developing, malignant melanoma in a subject, the method comprising the steps of: (a) measuring two or more markers in blood perfusion dynamics at and/or around a skin lesion site; and (b) determining if the two or more markers is different to a normal value. The invention also relates to a device for diagnosing/providing a prognosis to/for malignant melanoma in a subject..
Lancaster University Business Enterprises Limited


01/07/16
20160002308 

Microphthalmia-associated transcription factor-derived peptide and composition containing same


The present invention provides small peptide fragments derived from microphthalmia-associated transcription factor (mitf) and a pharmaceutical composition for preventing or treating melanoma comprising the same as an active ingredient. And also, the present invention provides a cosmetic composition for skin-whitening and/or for inhibiting skin pigmentation, comprising the peptide fragments as an active ingredient..
Knu-industry Cooperation Foundation


01/07/16
20160002230 

Pyrido[2,3-b]pyrazin-8-substituted compounds and their use


The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit raf (e.g., b-raf) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit raf (e.g., braf) activity, to inhibit receptor tyrosine kinase (rtk) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of raf, rtk, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc..
Cancer Research Technology Limited


01/07/16
20160002201 

Histone demethylase inhibitors


Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase.
Quanticel Pharmaceuticals, Inc.


01/07/16
20160000856 

Composition for preventing cancer and treating cancer and intensifying the effects of other anticancer drugs


This invention relates to a composition derived from chinese herbal medicines, medicinal plants and extracts thereof, and to its use for preventing cancer and treating cancer and intensifying the effects of other anticancer drugs. More specifically, the composition of the present invention is derived from various chinese herbal medicines or medicinal plants which have a long history of human consumption.

01/07/16
20160000841 

Compositions and methods for promoting growth of beneficial microbes to treat or prevent disease or prolong life


Inoculation of atm-deficient mice with probiotic microorganisms, such as l. Johnsonii, changed immune parameters, decreased a marker of dna damage and increased the lifespan of the mice.
The Regents Of The University Of California


01/07/16
20160000788 

Use of itk inhibitors for the treatment of cancer


This invention relates generally to the use of itk (il-2 inducible t-cell kinase) inhibitors for the treatment of patients who have melanoma or other solid tumors. Applicants demonstrate that itk lentiviral small hairpin rna knockdowns and a small molecule inhibitor can each decrease the proliferation and migration of melanoma cell lines and a small molecule inhibitor can be used to inhibit the growth of melanomas in vivo..
The University Of North Carolina At Chapel Hill


01/07/16
20160000082 

Herbicidal compositions comprising fluroxypyr and flumetsulam


Herbicidal compositions containing (a) fluroxypyr or an agriculturally acceptable salt or ester thereof and (b) flumetsulam or an agriculturally acceptable salt thereof provide synergistic herbicidal control of undesirable vegetation, e.g., in wheat, barley, oats, rye, sugarcane, rice, sorghum, corn/maize, soybean, rice, sunflower, canola/oilseed rape, sugarcane, sorghum, cotton, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, industrial vegetation management and rights-of-way; or crops comprising an aad-12 gene. Also provided herein are methods of using herbicidal compositions containing (a) fluroxypyr or an agriculturally acceptable salt or ester thereof and (b) flumetsulam or an agriculturally acceptable salt thereof..
Dow Agrosciences Llc


12/31/15
20150380117 

Concentrate treatment system


One aspect of the invention provides a system for treating wastestream, particularly a liquid or aqueous radwaste, for safe disposal and, in final processing, converting it into one or both forms including an aqueous form for safe discharge to the environment and a solidified form for safe disposal. Another aspect provides the capacity to employ a step where a specific target element strategy can be set up synchronizing sorbent substance choices and multiple recycle options to remove target substances from wastestream as a part of its sorption or powder sorbent isotopic reduction step (ii).
Diversified Technologies Services, Inc.


12/31/15
20150377751 

Method of collecting and quantifying melanin in skin


A non-invasive method of obtaining a melanin derivative from a test subject. The method includes contacting a target skin surface with an adhesive to provide a sample of biological material and obtaining the melanin derivative from the sample of biological material..
The Procter & Gamble Company


12/31/15
20150376717 

Methods and kits for detecting melanoma


This invention is directed to a method for detecting melanoma in a tissue sample by measuring a level of methylation of one or more regulatory elements differentially methylated in melanoma and benign nevi. The invention provides methods for detecting melanoma, related kits, and methods of screening for compounds to prevent or treat melanoma..
The University Of North Carolina At Chapel Hill


12/31/15
20150376584 

Methods of treating viral infections, particularly rabies, mers-cov, influenza, ebola, chikungunya, venezuelan equine encephalitus, canine parvovirus, adenovirus, respiratory syncytial virus, rhinovirus, and poxvirus in mammalian patients


Viral infections in mammals can be treated and prophylactically prevented by systemic administration of ranpirnase and three other ribonucleases that are highly homologous with it and that have activities that are highly similar to it. Experimental results against rabies, middle east respiratory syndrome coronavirus (“mers-cov”), influenza, ebola virus, chikungunya virus, venezuelan equine encephalitis, canine parvovirus, adenovirus-2, respiratory syncytial virus, rhinovirus-14, and vaccinia are disclosed..
Tamir Biotechnology, Inc.


12/31/15
20150376169 

Histone demethylase inhibitors


The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


12/31/15
20150374309 

Method and system for characterizing tissue in three dimensions using multimode optical measurements


A method and system are provided for characterizing a portion of biological tissue. A surface of the tissue is illuminated with light having a known wavelength spectrum capable of materially penetrating the tissue.

12/31/15
20150374276 

Method and system for characterizing tissue in three dimensions using multimode optical measurements


A method and system are provided for characterizing a portion of biological tissue. A surface of the tissue is illuminated with light having a known wavelength spectrum capable of materially penetrating the tissue.

12/31/15
20150373972 

Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and fungicides


Provided herein are synergistic herbicidal compositions containing (a) a compound of formula (i): or an agriculturally acceptable salt or carbendazim, difenoconazole, flutolanil, hexaconazole, iprobenfos, isoprothiolane, isotianil, kasugamycin, mancozeb, myclobutanil, phthalide, probenazole, propiconazole, pyroquilon, tebuconazole, thifluzamide, tricyclazole, trifloxystrobin, validamycin, or a compound of formula (ii) the compositions and methods provided herein control undesirable vegetation, e.g., in direct-seeded, water-seeded and transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn/maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, plantation crops, vegetables, industrial vegetation management (ivm) and rights-of-way (row).. .
Dow Agrosciences Llc


12/24/15
20150371192 

Apparatus and providing job searching services, recruitment services and/or recruitment-related services


An apparatus, including a memory device for storing work schedule information or scheduling information for an individual, independent contractor, temporary worker, or freelancer; a receiver for receiving a first request containing a request to obtain work schedule information or scheduling information for the individual, independent contractor, temporary worker, or freelancer, wherein the first request is received from a first communication device associated with an employer or hiring entity; a processing device for processing information contained in the first request, wherein the processing device generates a first message containing the work schedule information or the scheduling information for the individual, the independent contractor, the temporary worker, or the freelancer; and a transmitter for transmitting the first message to the first communication device. The apparatus processes information contained in a second request and reserves, engages, or requests, the services of the individual, independent contractor, temporary worker, or freelancer..

12/24/15
20150368547 

Heterogeneous proppant placement in a fracture with removable channelant fill


A method of heterogeneous proppant placement in a subterranean fracture is disclosed. The method comprises injecting well treatment fluid including proppant (16) wherein the proppant comprises from 1 to 100 percent in weight of stiff, low-elasticity and low-deformability elongated particles (34) and proppant-spacing filler material called a channelant (18) through a wellbore (10) into the fracture (20), heterogeneously placing the proppant in the fracture in a plurality of proppant clusters or islands (22) spaced apart by the channelant (24), and removing the channelant filler material (24) to form open channels (26) around the pillars (28) for fluid flow from the formation (14) through the fracture (20) toward the wellbore (10).
Schlumberger Technology Corporation


12/24/15
20150366957 

Melanoma-associated mhc class i associated oligopeptides and the uses thereof


The present invention relates to certain melanoma-associated oligopeptides that are recognized by cd8-positive cytotoxic t-lymphocytes (ctls) as peptide antigen and which elicit a ctl-induced lysis and/or apoptosis of tumor cells. The present invention also relates to the use of these melanoma-associated oligopeptides in cancer therapy..
Johannes Gutenberg-universität Mainz


12/24/15
20150366934 

Use of melanocortins to treat insulin sensitivity


The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as insulin resistance.. .
Ipsen Pharma S.a.s.


12/24/15
20150366895 

Cancer therapy using mirnas


The present invention relates generally to methods and compositions for the treatment of cancers expressing the type 1 insulin-like growth factor receptor (igf1r) or a constituent of an igf1r signaling pathway, in particular melanoma, using the microrna mir-7-5p. Also provided are methods for increasing the sensitivity of such cancers to therapeutic agents..
The University Of Western Australia


12/17/15
20150361509 

Diagnosis of melanoma and solar lentigo by nucleic acid analysis


The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin.
Dermtech International


12/17/15
20150361507 

Tert promoter mutations in gliomas and a subset of tumors


We surveyed 1,230 tumors of 60 different types and found that tumors could be divided into types with low (<15%) and high (≧15%) frequencies of tert promoter mutations. The nine tert-high tumor types almost always originated in tissues with relatively low rates of self renewal, including melanomas, liposarcomas, hepatocellular carcinomas, urothelial carcinomas, squamous cell carcinomas of the tongue, medulloblastomas, and subtypes of gliomas (including 83% of primary glioblastoma, the most common brain tumor type).
The Johns Hopkins University


12/17/15
20150361062 

Heterocyclo compounds as apoptotic inducers and uses thereof


Disclosed are heterocyclo compounds that have a formula represented by the following: and wherein x, r1, r2, r3, r4, r5, r6 and n are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of cancer conditions in mammals including humans, including by way of non-limiting example, prostate, colon, bladder, melanoma, liver, breast, cervical, ovarian, esophagi, glialblastoma, pancreatic and lung cancer..
New York University


12/17/15
20150361058 

Inhibition of macrophage migration inhibitory factor in melanoma and colon cancer


Compounds and compositions are provided which inhibit mif. Methods of treatment of melanoma and colon cancers are also provided..
The Feinstein Institute For Medical Research


12/17/15
20150359826 

Treating a melanoma with a whole, leech saliva extract


Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a melanoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° c.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech.
Biopep Solutions, Inc.


12/17/15
20150359734 

Formulations for lightening skin and treating hyperpigmentation


Formulations to treat skin discoloration via a multi-modal approach are provided in which select ingredients work together to effectively brighten skin and treat hyperpigmentation. An example formulation includes a first anti-melanin agent, a second anti-melanin agent, an anti-inflammatory agent, a sun protection agent, and an anti-oxidant.
Colorescience, Inc.


12/10/15
20150355185 

Using galectin-binding carbohydrates as predictors of melanoma progression and metastasis


Disclosed herein are assays and methods to determine tumor malignancy, for example, in melanoma or ovarian carcinoma, by determining the expression level of gal-1 ligands. Also provided are methods to assess the metastatic potential of a tumor..
The Brigham And Women's Hospital, Inc.


12/10/15
20150353622 

High avidity antigen recognizing constructs


The present invention pertains to novel high avidity antigen recognizing constructs, such as antibodies or t cell receptors, which specifically bind to the melanoma associated antigen (mage) a1. The constructs of the invention are particularly useful for the diagnosis, prevention or therapy of tumorous diseases which are characterized by the specific expression of the mage-a1 antigen.
Max-delbrÜck-centrum FÜr Molekulare Medizin (mdc) Berlin-buch


12/10/15
20150352378 

Method for treating skin cancer using radiation therapy


The described invention provides methods for irradiating skin cancer cells, such as melanoma cells, at a high radiation rate (e.g., of 2,400 mu/min) and a modest total dose (e.g., of 0.5 gy) to treat skin cancer or induce apoptosis in skin cancer cells. The radiation may be administered in a plurality of treatments and used in conjunction with chemotherapy..

12/10/15
20150352188 

Methods and compositions for treatment of bone, skin, subcutaneous, mucosal and/or submucosal cancer by percutaneous and/or transmucosal administration of interferon


The invention provides a method and/or composition for the treatment of bone cancer including primary bone cancer and secondary bone cancer, breast cancer, skin cancer, nasopharyngeal carcinoma, oral cancer, vulva cancer, prostate cancer, cervical cancer, melanoma including melanocarcinoma by percutaneous and/or transmucosal administration of the interferon. Further, the invention provides a method and/or composition for the treatment of skin, subcutaneous, mucosal and/or submucosal primary cancer and cancer metastatic lesions by percutaneous and/or transmucosal administration of the interferon, especially a method and/or composition for the treatment of bone cancer pain including pain resulted by secondary bone cancer..
Superlab Far East Limited


12/10/15
20150352022 

Cosmetic compositions and methods for inhibiting melanin synthesis


A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include undecylenoyl phenylalanine, hexyldecanol, and bisabolol.
The Procter & Gamble Company


12/10/15
20150351392 

Melanoidins and their use for improving properties of plants


The present invention relates to melanoidins and their use for improving properties of plants. The methods and compositions of the invention are particularly useful for control of fungal plant diseases and drought conditions, and promotion of plant growth..
The State Of Israel, Ministry Of Agriculture & Ru- Ral Development, Agricultural Research Organizati


12/03/15
20150347647 

Measurement and modeling of salinity contamination of soil and soil-water systems from oil and gas production activities


An analytical framework and modeling process for assessing salinity contamination of soil ecosystems in geographical areas related to oil and gas production sites combines detection and monitoring of unplanned saltwater releases from such production activities with soil impact prediction. The analytical framework and modeling process enables an assessment of risks associated with saltwater disposal from drilling operations to the surrounding environment and the impact on soils, aquifers, rangeland, cropland, and adjoining areas by monitoring water movement and other soil conditions, and generating predictive output data for landowners, farmers, oil and gas production site operators, governmental regulators, and other end users for contamination mitigation and agricultural activities..
Iteris, Inc.


12/03/15
20150347600 

Broadband centralized transportation communication vehicle for extracting transportation topics of information and monitoring terrorist data


Described herein is a search engine for extracting science, engineering, and transportation topics of information from a database such as the web and analyzing occurrences of the topics of information that were queried or found in the database to identify a pattern in which the topics were stored or extracted for providing communications responsive to different science, engineering, and transportation platforms, and enabling these platforms to talk to one another through a centralized system that integrates with government transportation agencies seamlessly in real time. The search engine provides centralized communications with existing transportation industries, science and engineering companies, homeland security departments, car rental companies and garages through their local existing systems and enable these systems to talk to each other and communicate better in real time interaction, real responsive, centralized database interaction, real resourceful, and real responsible to science, engineering, and transportation analysis and maintenance reprogramming, monitoring of terrorists desiring transportation topics, and providing centralized social network platforms for engineering students and engineering professionals..

12/03/15
20150345047 

Systems and methods for identifying drug combinations for reduced drug resistance in cancer treatment


Methods and systems are presented herein for creating and using cell type-specific, quantitative network models of signaling in cells, such as melanoma, to predict cellular response to untested combinational perturbations. The methods involve performing a set of perturbation experiments with cells of a particular type to produce phosphoproteomic and/or phenotypic profiles for the cells; automatically extracting prior pathway information from one or more known databases to build a qualitative prior model; building a signaling pathway model from (i) the phosphoproteomic and/or phenotypic profiles produced from the perturbation experiments and (ii) the qualitative prior model from the known database(s); and performing in silico perturbations using the signaling pathway model to predict responses to a set of perturbation conditions not yet experimentally tested, and identifying one or more candidate drug combinations from the predicted responses..
Memorial Sloan Kettering Cancer Center


12/03/15
20150344961 

Sera based mirnas as non-invasive biomarkers in melanoma


The present invention relates to serum marker micrornas (mirnas) which are associated with cancer, particularly melanoma, and to the assessment thereof in the prognosis, treatment and management of cancer. Embodiments include methods, compositions, kits and isolated nucleic acids.
New York University


12/03/15
20150344446 

Triazolone compounds and uses thereof


And pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocytic leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula i, or a pharmaceutically acceptable salt thereof.



Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph

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