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Elan patents



      
           
This page is updated frequently with new Elan-related patent applications. Subscribe to the Elan RSS feed to automatically get the update: related Elan RSS feeds. RSS updates for this page: Elan RSS RSS



Date/App# patent app List of recent Elan-related patents
08/20/15
20150233930 
 Methods and compositions employing secreted proteins that reflect autophagy dynamics within tumor cells patent thumbnailMethods and compositions employing secreted proteins that reflect autophagy dynamics within tumor cells
A diagnostic reagent or device for determining the autophagy levels of cancer cells comprises a ligand capable of specifically complexing with, binding to, or quantitatively detecting or identifying a biomarker selected from il-8, il-1β, dkk-3, fam-3c and/or lif, or an isoform, pro-form, modified molecular form including posttranslational modification, or unique peptide fragment or nucleic acid fragment thereof. Another reagent contains ligands to two or more of these biomarkers.
The Trustees Of The University Of Pennsylvania


08/20/15
20150233904 
 Detection of neurological diseases via measurement of neuromelanin in recirculating phagocytes patent thumbnailDetection of neurological diseases via measurement of neuromelanin in recirculating phagocytes
Methods for detecting or monitoring neurological or neurodegenerative diseases such as parkinson's disease via detection or measurement of central nervous system biomarkers within recirculating phagocytes after re-entry into the blood stream. The methods of the present invention may feature detecting neuromelanin in such recirculating phagocytes.
Msdx, Inc.


08/20/15
20150232575 
 Treatment of ocular diseases patent thumbnailTreatment of ocular diseases
Disclosed are methods for treating eye diseases or conditions characterized by vascular instability, vascular leakage and neovacularization such as diabetic macular edema, age-related macular edema, choroidal neovascularization, diabetic retinopathy, trauma, ocular ischemia, retinal angiomatous proliferation, macular telangiectasia and uveitis.. .
Aerpio Therapeutics Inc.


08/20/15
20150231276 
 Role of dh44 and homologs in calorie sensing patent thumbnailRole of dh44 and homologs in calorie sensing
Provided are methods for identifying drosophila melanogaster mutants which have mutations affecting calorie sensing behavior. Also provided are methods for identifying agents that can interfere with calorie sensing behavior in d.
New York University


08/20/15
20150231217 
 Composition and methods for treating melanoma patent thumbnailComposition and methods for treating melanoma
The present invention encompasses novel peptides useful for preventing and treating cancer, particularly melanoma. Multiple sequences of interest are provided and these sequences have been incorporated into other peptides to obtain a series of peptides of about 30 amino acid residues in length wherein the properties of each combine to yield an effective cocktail for treating melanoma, which surpasses the use of single peptides as immunogens, as well as shorter peptides as immunogens..
University Of Virginia Patent Foundation


08/20/15
20150231196 
 Uses of bremelanotide in therapy for female sexual dysfunction patent thumbnailUses of bremelanotide in therapy for female sexual dysfunction
Use of a subcutaneously administered dose of between about 1.0 mg and 1.75 mg of bremelanotide or a pharmaceutically acceptable salt of bremelanotide for the treatment of female sexual dysfunction in women while reducing or minimizing undesirable side effects.. .
Palatin Technologies, Inc.


08/20/15
20150231109 
 Combinations (catechins and methotrexate) for use in the treatment of melanomas patent thumbnailCombinations (catechins and methotrexate) for use in the treatment of melanomas
The invention provides a method of treatment of melanoma comprising administering a tyrosinase expression enhancer, such as mtx, and a tyrosinase-activated prodrug, such as tmecg or tmcg, to an individual in need thereof. Also provided is a method of treating melanoma comprising administering a tyrosinase-activated prodrug and a compound for differentiating a stem-like tumor cell into a matured cell that is a tyrosinase producer to an individual in need thereof.
Universidad De Murcia


08/13/15
20150224160 
 Plant extract, compositions containing same,  extraction and uses thereof patent thumbnailPlant extract, compositions containing same, extraction and uses thereof
An extract from leaves of mulberry is disclosed. The extract has an ic50 value sufficient to inhibit α-glucosidase i.
Botanic Century (beijing Co., Ltd.)


08/13/15
20150224095 
 Use of non-peptidic nk1 receptor antagonists for the production of apoptosis in tumor cells patent thumbnailUse of non-peptidic nk1 receptor antagonists for the production of apoptosis in tumor cells
Substance p antagonists and, in particular, non-peptidic nk1 receptor antagonists are useful for the treatment of cancer and, more specifically, human melanoma, neuroblastoma, glioma, human hodgkin's lymphoma km-h2, lymphoblastic leukemia, human rhabdomyosarcoma, human breast carcinoma, human burkitt's lymphoma, human lung carcinoma, human ewing's sarcoma, human glioma and human osteosarcoma.. .
Antagonista Enekauno, S.l.


08/06/15
20150221404 
 Concentrate treatment system patent thumbnailConcentrate treatment system
One aspect of the invention provides a system for treating wastestream, particularly a liquid or aqueous radwaste, for safe disposal and, in final processing, converting it into one or both forms including an aqueous form for safe discharge to the environment and a solidified form for safe disposal. Another aspect provides the capacity to employ a step where a specific target element strategy can be set up synchronizing sorbent substance choices and multiple recycle options to remove target substances from wastestream as a part of its sorption or powder sorbent isotopic reduction step (ii).
Diversified Technologies Services, Inc.


08/06/15
20150219612 

Water monitoring system


An anti-terrorism water quality monitoring system for continuously monitoring a potable water treatment system and related potable water distribution network that provides potable water to a municipality, city, housing development or other potable water consumer. The system includes the collection of data from the water distribution system and from the water treatment facility and from advanced separation processes which are integrated into analytical instruments.
Hach Company


08/06/15
20150218650 

Methods and kits for screening patients with a cancer


A method for screening patients with a cancer comprising i) determining in a tumor sample obtained from a patient an expression level ela1-elan of one or several genes ga1-gan representative of human adaptive immune response and an expression level eli1-elin of one or several genes gl1-gin representative of human immunosuppressive response, ii) comparing the expression levels ela1-elan and eli1-elin determined at step i) with predetermined reference values elra1-elran and elri1-elrin selected such as said predetermined reference values separate a panel of patients with a cancer into two groupings according to the expression level of said genes and to survival of patients according to kaplan meier curves analyses and associated logrank p values iii) concluding whether the patient has a good (level higher than the predetermined reference value) or a bad (level lower than the predetermined reference value) adaptive immune response and a good or a bad immunosuppressive response, optionally further comprising a step of concluding that a patient would or would not advantageously receive an antitumoral treatment, a kit comprising components for implementing step i) and a chemotherapeutic agent, an immunotherapeutic agent or a radiotherapeutic agent for use in the treatment of a cancer patient who is considered as responder to antitumoral treatment according to the method.. .
Assistance Publique Hopitaux De Paris


08/06/15
20150218649 

Biomarker associated with risk of melanoma reoccurrence


Wherein a higher level of expression of the plurality of pre-selected genes in the sample as compared with the predetermined reference level of expression of such genes indicates that the patient has a reduced risk of reoccurrence of melanoma.. .

08/06/15
20150218495 

Removal of tea and coffee stains by fatty acid soaps


Compositions for removal of coffee and tea stains from dishes and other ware are disclosed. Tea, coffee and other stains caused by tannins are particularly difficult to remove and traditional techniques include harsh treatments that use bleach, or other environmentally undesirable chemicals such as phosphates, edta, nta or other aminocarboxylates.
Ecolab Usa Inc


08/06/15
20150218436 

Biodegradable chelant for surfactant formulation


The present disclosure provides a surfactant composition for use in treating and recovering oil from an oil-bearing subterranean formation. The surfactant composition includes a primary surfactant and a biodegradable chelant comprising ethylenediamine disuccinc acid and/or sodium salts thereof.
Huntsman Petrochemical Llc


08/06/15
20150218266 

Inhibition of th17 cells migration to inflamed tissues using antibodies directed against mcam


Methods, uses, agents and compositions useful for the diagnosis, prevention and/or treatment of inflammatory conditions, such as neuroinflammatory conditions such as multiple sclerosis, and for the identification and selection of inflammatory cytokine-secreting t cell or a precursor thereof, based on the expression and/or modulation of melanoma cell adhesion molecule (mcam) are disclosed.. .
Val-chum, Limited Partnership


08/06/15
20150218093 

Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists


The present invention provides compounds of formula (i): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (mchr1) antagonists which may be used as medicaments..
Bristol-myers Squibb Company


08/06/15
20150218092 

Pyrrolone or pyrrolidinone melanin concentrating hormone receptor-1 antagonists


The present invention provides compounds of formula (i): as defined in the specification and compositions comprising any of such novel compounds. These compounds are melanin concentrating hormone receptor-1 (mchr1) antagonists which may be used as medicaments..
Bristol-myers Squibb Company


08/06/15
20150216209 

Sweetening compositions and processes for preparing them


The invention relates to sweetening compositions obtained from the luo han guo fruit, a member of the cucurbiticeae family. The compositions are free of bitter-tasting impurities, have a light colour and contain about 16-75% mogroside v and about 30-95% total terpene glycosides on a dry weight basis.
Waikato Innovation Park


07/30/15
20150209427 

Antibodies against kidney associated antigen 1 and antigen binding fragments thereof


Novel antibodies and antigen binding fragments that specifically bind to kaag1 and which may be used in the treatment, detection and diagnosis of cancer comprising kaag1-expressing cells are disclosed herein. Cells expressing the antibodies and antigen binding fragments as well as methods of detecting and treating cancer using the antibodies and fragments are also disclosed.
Alethia Biotherapeutics Inc.


07/30/15
20150209376 

Melanogenesis effect of saponins of gynostemma pentaphyllum


The present invention provides composition and method for inducing melanogenesis. The composition comprising an effective amount of saponins extracted from herbal plants..
Hong Kong Baptist University


07/30/15
20150209303 

Zeaxanthin for tumor treatment


A composition comprising a pharmaceutically effective amount of zeaxanthin or its derivative for use in treating a malignant tumor and a method of using a pharmaceutically effective amount of zeaxanthin or its derivative either alone or together with one or more pharmaceutical agents for treating a malignant tumor. The tumor may be, but is not limited to breast cancer, cervix cancer, colon cancer, cutaneous melanoma, cutaneous squamous carcinoma, hepatocellular carcinoma, lung cancer, osteosarcoma, prostate cancer, and uveal melanoma.
The New York Eye And Ear Infirmary


07/23/15
20150202290 

Method for treating melanoma using a herpes simplex virus and an immune checkpoint inhibitor


The invention relates to methods of treating melanoma using a herpes simplex virus in combination with an immune checkpoint inhibitor.. .
Amgen Inc.


07/23/15
20150202187 

Compositions and methods for treatment of vitiligo


Compositions and methods are disclosed for treating hypomelanotic conditions such as vitiligo and promoting melanogenesis.. .

07/23/15
20150201729 

Agents, compositions and devices for temporary coloring local hair areas


Hair-coloring applicators comprising a shield to protect the scalp, polymers of tannic acid having iron ions bound thereto, hair-coloring compositions comprising same and/or melanoidin, and novel alcohol-free carriers, are disclosed, as well uses thereof for coloring hair.. .
Kampalook Ltd.


07/16/15
20150198598 

Kit for diagnosing malignant melanoma


Provided is a kit for diagnosing at a high reproducibility, said kit being produced by preparing a monoclonal antibody against gpc3 and a monoclonal antibody against sparc that are superior in quality stability to commercially available and commonly employed antibodies, and using these antibodies.. .
National Cancer Center


07/16/15
20150197520 

Pyrazolopyridine and pyrazolopyrimidine derivatives as melanocortin-4 receptor modulators


Wherein x, r1, r2, and r3 are as defined herein, or a pharmaceutically acceptable salt thereof to allow the drug to penetrate the cell membrane; or a prodrug, or the compound is labeled with a detectable label or an affinity tag thereof. Also disclosed is a pharmaceutical composition, a method of treating a disorder mediated by melanocortin-4 receptors, and a method of treating obesity using the compounds described..

07/16/15
20150196545 

Method of treating cancer


This invention is directed to the treatment of cancer, particularly ocular melanoma, with a dual inhibitor of met and vegf such as compound 1.. .
Exelixis, Inc.


07/16/15
20150196351 

Method and treating medical conditions


A method and apparatus for treating a condition in a patient such as bph, irretractable infection, cyst, fibroid, or any mass such as prostate or breast cancer, skin cancer, melanoma, or any other soft tissue cancerous or benign mass, employs a unique, three-dimensional software-controlled electronic amplifier array using arbitrary waveforms that dynamically and proportionally steer electrical currents by using two or more current vector paths, sequentially or simultaneously, through a defined area containing electrically-conductive ionic solutions so as to obtain 100% thermal heating or hyperthermia through the defined area. The condition is treated or a mass is destroyed with a minimally-invasive treatment which requires no radiation or chemotherapy which could be harmful to the patient..

07/16/15
20150196031 

Screening assay for insecticides


The present invention relates to polypeptides, preferably from drosophila melanogaster (dmshal) as target for insecticides.. .
Basf Se


07/09/15
20150191797 

Systems and methods for diagnosing a predisposition to colon cancer


Systems and methods for diagnosing or characterizing a predisposition to colon cancer are provided. Cell nuclei may be evaluated for the presence or quantity of gamma-h2ax foci or their total gamma-h2ax levels.
Institute For Cancer Research D/b/a The Research Institute Of Fox Chase Cancer Center


07/02/15
20150186827 

Data-driven targeting of energy programs using time-series data


A method for enrolling utility customers in utility demand response or energy efficiency programs based on time-series consumption data includes collecting from smart meter sensors time-series utility consumption data from individual utility customers, extracting features from the consumption data, generating a probabilistic response model for each customer representing a relationship between the extracted features and customer program performance by estimating parameters of a response distribution, solving an optimization problem for each customer using the estimated response distribution to achieve a targeting objective, and enrolling selected customers in programs based on the solution to the optimization problem.. .
The Board Of Trustees Of The Leland Stanford Junior University


07/02/15
20150185218 

Methods and system for detecting melanoma


Use of the method for detecting melanoma in skin samples is also disclosed.. .

07/02/15
20150185217 

Myeloperoxidase, a risk indicator for cardiovascular disease


Diagnostic tests for characterizing an individual's risk of developing or having a cardiovascular disease. In one embodiment the present diagnostic test comprises determining the level of myeloperoxidase (mpo) activity in a bodily sample obtained from the individual or test subject.
The Cleveland Clinic Foundation


07/02/15
20150185204 

Circulating tumor cell diagnostics for lung cancer


The present invention provides methods for diagnosing lung cancer in a subject comprising (a) generating circulating tumor cell (ctc) data from a blood sample obtained from the subject based on a direct analysis comprising immunofluorescent staining and morphological characteristics of nucleated cells in the sample, wherein ctcs are identified in context of surrounding nucleated cells based on a combination of the immunofluorescent staining and morphological characteristics; (b) obtaining clinical data for the subject; (c) combining the ctc data with the clinical data to diagnose lung cancer in the subject.. .
The Board Of Trustees Of The Leland Stanford Junior University


07/02/15
20150184511 

Well testing and production apparatus and method


A well testing device for conducting well test operations on an oil, gas, or water well including a production flowline. A conduit guides fluids from the production flowline to the well test device and then back to the flowline.
Cameron Systems (ireland) Limited


07/02/15
20150184343 

Methods for removing hemicellulose


A method for treating a cellulosic material comprises extracting the cellulosic material with an extractant to selectively extract hemicellulose therein and separating the extracted hemicellulose to form a cellulosic product comprising less hemicellulose than the cellulose-containing material. The extractant comprises an amine oxide and a non-solvent.
Celanese International Corporation


07/02/15
20150184337 

Methods for removing hemicellulose


A method for treating a cellulosic material comprises extracting the cellulosic material with an extractant to selectively extract hemicellulose therein and separating the extracted hemicellulose to form a cellulosic product comprising less hemicellulose than the cellulose-containing material. The extractant comprises an ionic liquid and a non-solvent.
Celanese International Corporation


07/02/15
20150184131 

Enhanced efficiency of induced pluripotent stem cell generation


Human somatic cells are reprogrammed to become induced pluripotent stem cells (ips cells) by the introduction of a minicircle dna vector. Cells of interest include adipose stem cells..
The Board Of Trustees Of The Leland Stanford Junior University


07/02/15
20150184015 

Waterproofing coating compositions


A coating composition comprises an emulsion copolymer of a monomer mixture comprising at least one vinyl ester, ethylene, and a stabilizing system. The stabilizing system comprises at least one polyvinyl alcohol.
Celanese Emulsions Gmbh


07/02/15
20150183874 

Humanized and chimeric monoclonal antibodies to cd47


Humanized or chimeric anti-cd47 monoclonal antibodies are provided. The antibodies bind to and neutralize human cd47, and find use in various therapeutic methods.
The Board Of Trustees Of The Leland Stanford Junior University


07/02/15
20150183793 

Compounds and methods for kinase modulation, and indications therefor


Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of fms, kit, flt3, trka, trkb and trkc kinase protein.
Plexxikon Inc.


07/02/15
20150183727 

Method for the preparation of 1-aryl-1-alkyl-2-alkyl-3-dialkylaminopropane compounds


The present invention refers to the preparation of 1-aryl-1-alkyl-2-alkyl-3-dialkylamino-propane compounds, such as tapentadol, using a diastereoselective eschenmoser-claisen or ireland-claisen rearrangement.. .
Siegfried Ag


07/02/15
20150183655 

Microparticles and a sytem and the synthesis of microparticles


There is provided a method of producing microparticles using an emulsion based synthesis route including: providing a first fluid phase and a second fluid phase, wherein the first fluid phase is a continuous phase and the second fluid phase is a dispersed phase comprising a dispersed material, wherein the continuous phase is immiscible with the dispersed phase; mixing the first continuous phase and the second dispersed phase in the presence of a surfactant in a shear device to form an emulsion of droplets of controllable size and having a narrow drop size distribution; drying the emulsion to form microparticles of controllable size and having narrow size distribution, and wherein the microparticles may comprise spherical, crumpled, dimpled, porous or hollow microparticles morphology. Also provided is a system including shear device and drying arrangement.
University College Dublin, National University Of Ireland, Dublin


07/02/15
20150182987 

Movable mask for a thermal and/or kinetic coating system


The invention relates to a mask for a coating system having a covering device for an area not to be coated of a substrate to be coated, having a working side exposed to the material flow of the coating material, wherein the covering device for the area not to be coated is comprised of at least one disk that can be rotated, the disk upper side of which is positioned vertically to the material flow of the coating material. A further aspect of the invention includes a thermal and/or kinetic coating system having at least one spray device, and a corresponding method for producing a coated substrate..
Wieland-werke Ag


07/02/15
20150182634 

Molecular design and chemical synthesis of pharmaceutical-ligands and pharmaceutical-pharmaceutical analogs with multiple mechanisms of action


Multi-phase and single-phase chemical reaction schemes have been developed for the synthesis of pharmaceutical-ligand analogs, pharmaceutical-pharmaceutical analogs, and similar molecular-molecular analogs that possess multiple mechanisms of action. The multi-phase organic chemical reaction schemes include relatively mild reaction conditions, high end product yields, and comparatively rapid completion of chemical reactions, which are all of particular utility for the synthesis of preparations including covalent pharmaceutical-receptor ligand or pharmaceutical-immunoglobulin analogs.

07/02/15
20150182614 

Vaccine for prophylaxis or treatment of an allergen-driven airway pathology


The present invention relates to a life attenuated bordetella pertussis vaccine which is deficient for tracheal cytotoxin (tct), pertussis toxin (ptx), and dermonecrotic toxin (dnt) for prophylaxis or treatment of an allergen-driven airway pathology.. .
National University Of Ireland Maynooth


07/02/15
20150182587 

Methods for treating reperfusion injuries


The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin. .
Cleveland Clinic Foundation


07/02/15
20150182526 

Pyrido[2,3-b]pyrazin-8-substituted compounds and their use


The present invention pertains generally to the field of therapeutic compounds for treating proliferative disorders, cancer, etc., and more specifically to certain pyrido[2,3-b]pyrazin-8-substituted compounds, as described herein, which, inter alia, inhibit raf (e.g., b-raf) activity. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit raf (e.g., braf) activity, to inhibit receptor tyrosine kinase (rtk) activity, to inhibit cell proliferation, and in the treatment of diseases and disorders that are ameliorated by the inhibition of raf, rtk, etc., proliferative disorders such as cancer (e.g., colorectal cancer, melanoma), etc..
Cancer Research Technology Limited


07/02/15
20150182511 

Modulators of aldehyde dehydrogenase activity and methods of use thereof


The present invention provides compounds that function as modulators of aldehyde dehydrogenase activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition..
The Board Of Trustees Of The Leland Stanford Junior University


07/02/15
20150182506 

Modulators of aldehyde dehydrogenase and methods of use thereof


The present disclosure provides compounds that function as modulators of aldehyde dehydrogenase (aldh) enzymatic activity, as well as compositions and formulations comprising the compounds. The present disclosure provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition..
The Board Of Trustees Of The Leland Stanford Junior University


07/02/15
20150182443 

Traditional chinese medicine extract composition with whitening skin-care function adn its preparation method


The invention provides a raised white skin rejuvenation medicine composition, wherein said composition comprises the following servings by weight of the composition ratio of raw material: 5 to 10 servings of water, 2 to 5 servings of orchids extract, 2 to 3 servings of winter worm of summer, 2 servings of vitamin-c1, 5 servings of almond oil, 2-3 servings of sucrose laurate, 2-3 servings of oat amino acids, 3-4 servings of hyaluronic acid, 2 to 3 servings of muti pearl, 2 to 3 of pennisetum extract, 2 to 3 servings of white chrysanthemum extract, 2 to 3 servings of white peony extract, 2 to 3 servings of poria extract. The above composition was prepared according to the method of the invention, the composition has activated, whitening, moisturizing super protection function can inhibit the formation of melanin and plant extracts such as angelica restore melanin already formed, the epidermal melanin exclusion dilute huang, make skin white and transparent..
Shang Chen Mei Bang (beijing) Biotechnology Co., Ltd.


07/02/15
20150182432 

Phenyl ketone derivatives as self-tanning agents


The present invention relates to the use of phenyl ketone derivatives of the formula i for use as self-tanning substance or for increasing melanin synthesis, improving melanin transport and/or improving the distribution of melanin in suprabasal layers, and to preparations comprising these phenyl ketone derivatives.. .
Merck Patent Gmbh




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Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph

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