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Elan patents



      

This page is updated frequently with new Elan-related patent applications.




Date/App# patent app List of recent Elan-related patents
06/23/16
20160180282 
 Systems and methods for crowdfunding and crowdsourcing a project patent thumbnailSystems and methods for crowdfunding and crowdsourcing a project
A system and method for crowdfunding and crowdsourcing a project that receives, via communication circuitry, a project from a user, determines, using processing circuitry, whether the project adheres to a predetermined criteria, provides the project to a crowdsourcing community and a crowdfunding community, receives bids from one or more freelancers to implement one or more parts of the project, receives contributions from one or more contributors, selects at least one freelancer based on a predefined rule, determines a total amount of contributions, determines a total amount of funds needed, determines whether the total amount of contributions is at least equal to the total amount of funds needed, assigns the one or more parts of the project to the selected at least one freelancer, transmits an alert to at least on device associated with the selected at least one freelancer, and submits payments to the selected at least one freelancer.. .

06/23/16
20160177232 
 Method of automatic dishwashing patent thumbnailMethod of automatic dishwashing
A method of cleaning a dishwashing load comprising dishware and tableware having bleachable stains in the presence of iron in a dishwasher, the method comprising the step of contacting the ware with a detergent composition comprising an iron chelant wherein the detergent composition is free or substantially free of bleach and preferably has a ph as measured in 1% weight aqueous solution at 25° c. Of from about 5 to about 7.5.

06/23/16
20160177229 
 Detergent composition patent thumbnailDetergent composition
A substantially builder-free low-ph automatic dishwashing detergent composition comprising a buffer, an enzyme and an iron chelant and wherein the composition has a ph as measured in 1% weight aqueous solution at 25° c. Of from about 5 to about 7.5..

06/23/16
20160176925 
 Melanocortin receptor ligands modified with hydantoin patent thumbnailMelanocortin receptor ligands modified with hydantoin
The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.. .

06/23/16
20160175391 
 Drug containing recombinant mistletoe lectins for treating malignant melanoma patent thumbnailDrug containing recombinant mistletoe lectins for treating malignant melanoma
The invention relates to a drug and/or pharmaceutical composition for treating metastatic tumors, in particular of malignant melanoma, above all of stage iv malignant melanoma, and to the use of said drug, in particular the use of said drug in select patient populations.. .

06/23/16
20160175384 
 Melanotropin ligands for skin care patent thumbnailMelanotropin ligands for skin care
A melanocortin 1 receptor (mc1r) peptide ligand-elastic vesicle complex. The mc1r peptide ligand is modified by coupling the mc1r ligand to a functionality or linker, such as a click functionality, for conjugation to a surface or agent.

06/23/16
20160175210 
 Method of inhibiting copper deposition on hair patent thumbnailMethod of inhibiting copper deposition on hair
A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a bleaching or oxidative dyeing composition comprising a chelant, rinsing the bleaching or oxidative dyeing composition, applying to the hair a rinse-off conditioner composition comprising histidine, rinsing the rinse-off conditioner composition from the hair, applying to the hair a shampoo composition having ethylenediamine-n,n′-disuccinic acid and/or histidine, rinsing the shampoo composition from the hair, applying to the hair a rinse-off conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.. .

06/23/16
20160174603 
 Electronic vapor liquid composition and  use patent thumbnailElectronic vapor liquid composition and use
An e-liquid for use in electronic cigarettes which utilizes a vaporizing base (either propylene glycol, vegetable glycerin, or mixture of the two) mixed with an herbal powder extract generally at a 0.001 g-2.0 g per 1 ml ratio. The herbal extract can be any of the following: kanna (sceletium tortuosum), blue lotus (nymphaea caerulea), salvia (salvia divinorum), salvia eivinorm, kratom (mitragyna speciosa), celandine poppy (stylophorum diphyllum), mugwort (artemisia), coltsfoot leaf (tussilago farfara), california poppy (eschscholzia californica), sinicuichi (heimia salicifolia), st.

06/23/16
20160174595 
 Method for reduction of flying insects in livestock feeds and feed supplements patent thumbnailMethod for reduction of flying insects in livestock feeds and feed supplements
Methods for reducing flying insects from animal feeds or animal feed supplements involve, in a location accessible to flying insects, providing a livestock animal with an animal feed or a liquid supplement and a palatant or a molasses replacement in an amount effective to reduce flying insects from occupying an area on and around the animal feed or the liquid supplement. The palatant or the hydrolyzed whey within the palatant may account for at least about 2 percent of the animal feed or liquid supplement by weight.

06/16/16
20160168227 
 Composition and vaccine for treating lung cancer patent thumbnailComposition and vaccine for treating lung cancer
The present invention relates to a composition comprising at least one mrna encoding a combination of antigens capable of eliciting an (adaptive) immune response in a mammal, wherein the antigens are selected from the group consisting of 5t4 (trophoblast glycoprotein, tpbg), survivin (baculoviral tap repeat-containing protein 5; birc5), ny-eso-1 (new york esophageal squamous cell carcinoma 1, ctag1b), mage-c1 (melanoma antigen family c1), mage-c2 (melanoma antigen family c2), and muc1 (mucin 1). The invention furthermore relates to a vaccine comprising at least one mrna encoding such a combination of antigens, and to the use of said composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, preferably of non-small cell lung cancer (nsclc), and diseases or disorders related thereto.
Curevac Ag


06/16/16
20160168121 

Quinoline derivative


A compound represented by general formula (i) has a strong axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.. .
Ono Pharmaceutical Co., Ltd.


06/16/16
20160166194 

System and optical detection of skin disease


An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.. .
The Rockefeller University


06/16/16
20160165891 

Synergistic herbicidal composition containing penoxsulam, triclopyr and bispyribac


Methods for controlling weeds using synergistic compositions containing penoxsulam, triclopyr, and bispyribac, especially rice, sugarcane, cereal and grain crops, pastures, rangelands, industrial vegetation management (ivm), aquatics and turf, as well as protecting crops from herbicidal injury caused by any of the individual components. These methods provide improved post-emergence herbicidal weed control and reduce herbicidal injury by concomitant application of the mixture..
Dow Agrosciences Llc


06/09/16
20160162731 

Method and system for optimizing accuracy-specificity trade-offs in large scale visual recognition


As visual recognition scales up to ever larger numbers of categories, maintaining high accuracy is increasingly difficult. Embodiment of the present invention include methods for optimizing accuracy-specificity trade-offs in large scale recognition where object categories form a semantic hierarchy consisting of many levels of abstraction..
The Board Of Trustees Of The Leland Stanford Junior University


06/09/16
20160161438 

Sensing platform for quantum transduction of chemical information


A system for determining chemistry of a molecule in a high background interfering liquid environment by application of an electronic signal at a biased metal-electrolyte interface is disclosed. One or more of a resonant exchange of energy between one or more electrons exchanged by the metal and the electrolyte and vibrating bonds of a molecular analyte, for example, may be sensed by measuring small signal conductivity of an electrochemical interface..
The Board Of Trustees Of The Leland Stanford Junior University


06/09/16
20160160208 

Capillary barriers for staged loading of microfluidic devices


Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure.
The Board Of Trustees Of The Leland Stanford Junior University


06/09/16
20160159832 

Silylalkyloxyaryl compounds and methods for treating cancer


Silylalkyloxyaryl compounds useful as anti-cancer agents. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of melanoma, colon, neuroblastoma, bladder, breast, lung, pancreatic, melanoma, sarcoma, lymphoma or gastric cancer..
The Regents Of The University Of Colorado, A Body Corporate


06/09/16
20160159803 

Pteridines useful as hcv inhibitors and methods for the preparation thereof


The present invention relates to the use of pteridines as inhibitors of hcv replication as well as their use in pharmaceutical compositions aimed to treat or combat hcv infections. In addition, the present invention relates to compounds per se and their use as medicines.
Janssen Sciencies Ireland Uc


06/09/16
20160159721 

Processes for producing an acetic acid product having low butyl acetate content


A process for producing an acetic acid product having low butyl acetate content via a carbonylation reaction. The carbonylation reaction is carried out at a temperature from 100 to 300° c., a hydrogen partial pressure from 0.3 to 2 atm, and a metal catalyst concentration from 100 to 3000 wppm, based on the weight of the reaction medium.
Celanese International Corporation


06/02/16
20160153968 

Method of screening for candidate compounds for regulating melanogenesis or pigmentation


A method to identify target genes or proteins for regulating melanogenesis or pigmentation and to screen for compounds for manipulation of melanogenesis or pigmentation, the method of screening for candidate compounds for regulating melanogenesis or pigmentation, includes bringing test compounds into contact with cells capable of expressing mortalin and/or hsp60 in vitro, and selecting, from among the test compounds, a compound that changes the expression level of mortalin and/or hsp60.. .
National Institute Of Advanced Industrial Science And Technology


06/02/16
20160152986 

Methods and materials for treating cancer


This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an scd1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccrcc)) or to increase the efficacy of a renal cell carcinoma treatment are provided.
Mayo Foundation For Medical Education And Research


05/26/16
20160146600 

Novel technique of displacement and rotation measurement


A simple and reliable novel method providing the ability to measure the spatial relative displacement and rotation of objects as well as the measurement of the different degrees of freedom of each object (i.e. Rotations and translations) relative to an inertial frame.

05/26/16
20160145206 

N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use


The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (copd); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as behçet's disease.
Pimco 2664 Limited


05/26/16
20160143255 

Animal models of ataxia-telangiectasia (a-t)


The present invention provides transgenic, large non-human animal models of ataxia-telangiectasia, as well as methods of using such animal models in the identification and characterization of therapies for ataxia-telangiectasia.. .
Exemplar Genetics, Llc


05/19/16
20160143195 

Immobilized melanin and its chemical derivatives for the harvesting or shielding of high energy electromagnetic radiation


A method and apparatus for a photocatalytic and electrolytic electromagnetic shielding and responsive polymer includes in various aspects one or more electromagnetic shielding and responsive polymers, a method for forming a electromagnetic shielding and responsive polymer, an electrolytic electromagnetic energy dispersion cell, and a reaction method, as well as applications.. .

05/19/16
20160139132 

Method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm


The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression of cavcolin-1, cavcolin-2, vimentin, calponon2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, ef-i-delta, or m2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.. .
Thomas Jefferson University


05/19/16
20160136132 

A pharmaceutical combination for the treatment of melanoma


The present invention relates to a pharmaceutical combination comprising a cyclin dependent kinase (cdk) inhibitor represented by a compound of formula i (as described herein) or a pharmaceutically acceptable salt thereof; and at least one anticancer agent selected from a braf inhibitor or a mek inhibitor, for use in the treatment of melanoma. The present invention also relates to a method for the treatment of melanoma comprising administering to a subject in need thereof, a therapeutically effective amount of a cdk inhibitor and a therapeutically effective amount of at least one anticancer agent selected from a braf inhibitor or a mek inhibitor..
Piramal Enterprises Limited


05/19/16
20160136079 

A3 adenosine receptor ligands for modulation of pigmentation


The present invention relates to compositions and methods for modulating melanin production, secretion and/or accumulation in human skin cells. In particular, the present invention relates to the use of a3 adenosine receptor antagonists in compositions and methods for the treatment and amelioration of hyper-pigmentation conditions and for the lightening of skin, and to the use of a3 adenosine receptor agonists in compositions and methods for the treatment and amelioration of hypo-pigmentation conditions and for the tanning of skin..
Oradin Pharmaceutical Ltd.


05/19/16
20160136070 

Methods and compositions for enhancing skin pigmentation


Described herein are methods and compositions useful for enhancing pigmentation, such as skin, eye and/or hair pigmentation comprising administering e.g., an nnt inhibitor or an agent that modifies redox status in a melanocyte.. .
The General Hospital Corporation


05/19/16
20160135889 

Method for depilation by photothermolysis with melanin


Improved melanin-enhanced photothermolysis hair removal method, which includes the application of liposome-encapsulated melanin solutions as a chromophore onto the skin and the use of mechanical devices having microneedles to favor absorption thereof by the hair follicles.. .
Dermopartners,s.l.


05/12/16
20160130625 

Methods for producing melanin and inorganic fertilizer from fermentation leachates


Melanin or inorganic fertilizers are produced from fermentation leachates or from low-cost nutrient-rich solutions. The method for producing the melanin or inorganic fertilizer comprises repetitive trophic cycling in the controlled conditions of primary and secondary bioreactors.
River Road Research, Inc.


05/12/16
20160130534 

Pourable detergent composition comprising suspended particles


The present invention relates to a pourable thixotropic detergent composition comprising a continuous phase and at least 0.3 wt. % of suspended particles comprising water-soluble surfactant, said continuous phase containing at least 10 wt.
Conopco, Inc., D/b/a Unilever


05/12/16
20160130532 

Hygroscopic detergent formulation comprising water, aminocarboxylate chelant and moisture-sensitive ingredients


The present invention relates to a detergent formulation comprising water, one or more moisture-sensitive detergent ingredients and an aminocarboxylate chelant comprising at least three carboxylate residues; wherein the combination of aminocarboxylate chelant and water represents at least 20% by weight of the detergent formulation; wherein the weight ratio of aminocarboxylate chelant to water lies within the range of 5:6 to 5:1; and wherein the detergent formulation has a ph in the range of 7.2 to 12. The detergent composition offers the advantage that adverse effects of water uptake during storage are minimized.
Conopco, Inc., D/b/a Unilever


05/12/16
20160129077 

Use of recombinant ganoderma immunoregulatory protein (rlz-8) in preparation of drug for treating melanoma


A use of recombinant ganoderma immunoregulatory protein (rlz-8) in a preparation of a drug for treating melanoma is disclosed. By establishing experimental animal models of orthotopic tumors and metastatic tumors, an anti-tumor effect of the rlz-8 is researched, which indicates that the rlz-8 significantly inhibits a growth of the orthotopic tumors of the melanoma and a formation of metastases of the melanoma..

05/12/16
20160129009 

High purity diaminophenothiazinium compounds including methylthioninium chloride (mtc)


This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including methythioninium chloride (mtc) (also known as methylene blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (nos); nitrosyl reduction (nr); thiosulfonic acid formation (tsaf); oxidative coupling (oc); cr(vi) reduction (cr); isolation and purification of zwitterionic intermediate (iapozi); ring closure (rc); chloride salt-formation (csf); one of: sulphide treatment (st); dimethyldithiocarbamate treatment (dt); carbonate treatment (ct); ethylenediaminetetraacetic acid treatment (edtat); organic extraction (oe); and recrystallisation (rx).
Wista Laboratories Ltd.


05/05/16
20160122323 

Inhibitors of cyclin-dependent kinase 7 (cdk7)


The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.


05/05/16
20160122314 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


05/05/16
20160120914 

Treating a lymphoma with a whole, leech saliva extract


Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a melanoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° c.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech.
Biopep Solutions, Inc.


04/28/16
20160115555 

Biomarkers for differentiating melanoma from benign nevus in the skin


Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (phactr1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (spp1), preferentially expressed antigen in melanoma (prame), growth differentiation factor 15 (gdf15), and chemokine c-x-c motif ligand 10 (cxcl10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of phactr1, or fragments thereof, either alone or in combination with the detection of spp1, prame, gdf15, and cxcl10, for the diagnosis or prognosis of melanoma..
Advanced Cell Diagnostics


04/28/16
20160115468 

Albumin-binding arginine deiminase for cancer targeting treatment and detection of arginine


The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase (aad) fusion protein for treating cancer or other arginine-dependent diseases. The aad fusion protein can be purified from both soluble and insoluble fractions of crude proteins, it binds to human serum albumin (hsa) or animal serum albumin and has its high activity with longer half life for efficient depletion of arginine in cancer cells.
Vision Global Holdings Ltd.


04/28/16
20160115131 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals. Inc.


04/28/16
20160113935 

Composition including atm inhibitor for reducing cellular senescence and use of the composition


A composition including an ataxia telangiectasia mutated (atm) inhibitor for reducing cellular senescence, a method of reducing cellular senescence in a mammal, and a method of treating a symptom associated with cellular senescence in a mammal.. .
Samsung Electronics Co., Ltd.


04/28/16
20160113914 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


04/21/16
20160108046 

Inhibitors of lysine specific demethylase-1


The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds.

04/21/16
20160108033 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds.

04/21/16
20160108032 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds.

04/21/16
20160107995 

Histone demethylase inhibitors


The present disclosure relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyridine derivative compounds and pharmaceutical compositions comprising said compounds.

04/21/16
20160106853 

Curcumin conjugates for treating and preventing cancers


Conjugating lhrh to curcumin (lhrh-curcumin) substantially enhances the bioavailability of curcumin, targets it to cells expressing lhrh receptors, facilitates intravenous administration, and increases the anti-cancer efficacy of curcumin. The conjugate may be used against cancer cells that express the lhrh receptor: pancreas, prostate, breast, testicular, uterine, ovarian, melanoma.

04/14/16
20160102242 

Treatment fluid and method


A treatment fluid made of mineral acid, viscoelastic surfactant, at least one of a fluoride source and a chelant, and optionally a corrosion inhibitor. A method of combining a mineral acid, viscoelastic surfactant, at least one of a fluoride source and a chelant, and optionally a corrosion inhibitor, in a fluid mixture.

04/07/16
20160096841 

Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith


Wherein r1, r2, and r3 are as defined herein, compositions comprising an effective amount of an aminopurine compound, and methods for treating or preventing a cancer, for example, melanoma.. .

04/07/16
20160096825 

Furanone compounds as kinase inhibitors


The present disclosure provides novel furanone compounds, or pharmaceutically acceptable salts, solvates or prodrugs thereof, as raf kinase, especially braf kinase, inhibitors, which are useful therapeutic agents for treatment of raf kinase related diseases or disorders, such as melanomas, cancers, and leukemia. The disclosure also provides methods and processes for preparing these novel furanone compounds, pharmaceutical compositions containing these furanone compounds, and methods of treatment using these furanone compounds..
Eternity Bioscience Inc.


04/07/16
20160096823 

Aminopyridyloxypyrazole compounds


The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (tgfβr1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.. .
Eli Lilly And Company


03/31/16
20160094965 

Access to wireless emergency alert information via the spectrum access system


The spectrum access system (sas) may be utilized wireless emergency alert (wea) information. The sas may be utilized to retrieve additional wea information, beyond that which was provided in a wea message.
At&t Intellectual Property I, L.p.


03/31/16
20160092723 

Elapsed-time determination apparatus, deciding apparatus, deciding method, and non-transitory computer-readable recording medium storing control program


An elapsed-time determination apparatus includes: a storage unit that stores correlation information indicating a correlation between a state of a melanophore of a fish and an amount of time elapsed since the death of the fish; an acquisition unit that acquires an image of a fish; an analysis unit that detects a state of a melanophore of a fish by analyzing an image acquired by the acquisition unit; and a determination unit that determines the amount of time elapsed since the death of the fish in accordance with the state of the melanophore of the fish detected by the analysis unit, based on the correlation information, and outputs determination results.. .
Panasonic Corporation


03/31/16
20160089319 

Actives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin


A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin..
Elc Management Llc


03/24/16
20160083379 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


03/24/16
20160083322 

Series of skin-whitening (lightening) compounds


The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin..
Unigen, Inc.




Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph

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