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Diagnostic radio frequency identification sensors and applications thereof
|| List of recent Elan-related patents
| Methodology for determining concentration of the types of melanin pigment in the skin|
The present invention relates generally to a methodology of determining the concentration of the types of melanin, either eumelanin or pheomelanin, in the skin wherein the process for such determination is non-invasive and based on digital signal and image analysis of hyperspectral sensing and multi-spectral data.. .
Institute Of Technology Petronas Sdn Bhd
| Pharmaceutical composition|
Disclosed in the present invention is a pharmaceutical composition, comprising a weight ratio of 1:120 to 1:1000 of camptothecin compound of formula i and β-cyclodextrin or derivatives thereof, and an acidic buffer to adjust the ph=3.5-6.0. The composition can be used to treat solid tumours, such as melanoma, pancreatic cancer, hepatoma etc.
Shanghai Hotmed Sciences Co., Ltd.
| Herbicidal compositions comprising sulfentrazone plus propyzamide and sulfentrazone plus propyzamide plus ethalfluralin|
Provided herein are herbicidal compositions containing (a) sulfentrazone and (b) propyzamide and (a) sulfentrazone and (b) propyzamide and (c) ethalfluralin. The compositions provide synergistic weed control of undesirable vegetation, e.g., in wheat, barley, oats, rye, sorghum, corn or maize, oilseed rape, mustard crops, soybeans, vegetables, pulse crops (e.g., common bean, field pea, chickpea, lentil and faba bean), pastures, grasslands, rangelands, fallow land, turf, tree and vine orchards, industrial vegetation management or rights-of-way..
Dow Agrosciences Llc
| Equine encephalitis virus vaccines and methods of using thereof|
Disclosed herein are nucleotide sequences which encode a plurality of structural proteins, except the capsid, of an equine encephalitis virus, wherein the nucleotide sequence is codon-optimized for mammalian expression. The nucleotide sequences are codon-optimized for expression in humans.
| P97 fragments with transfer activity|
The present invention is related to fragments of human melanotransferrin (p97). In particular, this invention relates to treatment of diseases through the introduction of the melanotransferrin fragment conjugated to a therapeutic or diagnostic agent to a subject..
Bioasis Technologies, Inc.
| Selective histone deactylase 6 inhibitors|
Disclosed are selective histone deactylase inhibitors (hdaci) that having formula (i). Methods of making and using these inhibitors for the treatment of cancer, in particular melanoma are also disclosed..
Board Of Trustees Of The University Of Illinois
| Diagnostic radio frequency identification sensors and applications thereof|
An integrated passive wireless chip diagnostic sensor system is described that can be interrogated remotely with a wireless device such as a modified cell phone incorporating multi-protocol rfid reader capabilities (such as the emerging gen-2 standard) or bluetooth, providing universal easy to use, low cost and immediate quantitative analyses, geolocation and sensor networking capabilities to users of the technology. The present invention can be integrated into various diagnostic platforms and is applicable for use with low power sensors such as thin films, mems, electrochemical, thermal, resistive, nano or microfluidic sensor technologies.
|Coating compositions having chelant functionality|
The present invention provides an aqueous opaque coating formulation comprising (a) and aqueous solvent; (b) an inorganic material; and (c) a chelating polymer which comprises units derived from one or more aminocarboxylate compounds or their salts, one or more other polymerizable monomers, one or more ethylenically unsaturated monomers and, optionally, one or more crosslinking monomers. For example, the aminocarboxylate compounds or their salts may be one or more of iminodiacetic acid (ida), iminodisuccinic acid (ids), ethylenediamine triacetic acid (ed3a) and ethylenediamine disuccinic acid (edds), or their salts.
Rohm And Haas Company
Provided is a display apparatus and a method of manufacture. The display apparatus includes a first substrate with a plurality of organic electroluminescence devices, a second substrate with a color filter, the second substrate facing the first substrate, and an adhesive layer disposed between the first substrate and the second substrate so as to cover the plurality of organic electroluminescence devices, the adhesive layer being made of a material selected from the group consisting of a phenol resin, a melanin resin, an unsaturated polyester resin, an epoxy resin, a silicon resin and a polyurethane resin..
|Methods and materials for treating cancer|
This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an scd1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccrcc)) or to increase the efficacy of a renal cell carcinoma treatment are provided.
Mayo Foundation For Medical Education And Research
Pharmaceutical cream compositions and methods of use
Embodiments relating to cream formulations as well as oxymetazoline creams and methods for treating rosacea and symptoms associated with rosacea, including, for example, papules, pustules, phymas (skin thickening), telangiectasias or erythema associated with rosacea, other skin erythemas, telangiectasias, purpura or the like, and other manifestations associated therewith; other inflammatory conditions of the skin including, but not limited to, keratosis pilaris, lupus miliaris dissemniatus faciei, eczema, dermatitis, such as contact dermatitis, atopic dermatitis, seborrheic dermatitis, nummular dermatitis, generalized exfoliative dermatitis, statis dermatitis, neurodermatitis, lichen simplex chronicus, xerosis and xerotic dermatitis, dyshidrosis and dyshidrotic dermatitis, asteototic dermatitis or other conditions characterized by sensitive skin or a disturbance of the epidermal barrier; disorders characterized by rough, dry, cracked or fissured skin, disorders characterized by hyperkeratotic skin such as keratodermas and ichthyosisis and ichthyosiform dermatoses; disorders of hair follicles and sebaceous glands, such as acne, perioral dermatitis, and pseudofolliculitis barbae; disorders of sweat glands, such as miliaria, including, but not limited to, miliaria crystallina, miliaria rubra, miliaria profunda, miliaria pustulosa; sunburn, chronic actinic damage, poikiloderma, radiation dermatitis, actinic purpura (“solar purpura”); other inflammatory dermatoses, reactions and conditions of the skin, including, but not limited to, psoriasis, drug eruptions, erythema multiforme, erythema nodosum, and granuloma annulare; diseases and conditions characterized by bleeding or bruising such as petechiae, ecchymosis, purpura and the like including any accumulation of blood in the skin due to vascular extravasation, irrespective of size or cause, bleeding or bruising due to any skin injury which may include any trauma including surgical or procedural trauma; infection, inflammatory dermatoses or inflammation due to any cause using such creams are described herein.. .
Prodrugs of riluzole and their use
Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process..
Rutgers, The State University Of New Jersey
Melanocortin analogs having enhanced activity and transport
Described herein are melanocortin analogs having enhanced activity and transport.. .
Tensive Controls Inc.
Monoclonal antibodies and diagnostic uses thereof
The disclosure relates to antibodies to the preferentially expressed antigen in melanoma (prame), and the synovial sarcoma x breakpoint 2 (ssx-2) antigens, methods of use, and diagnostic kits thereof. In exemplary embodiments, the disclosure relates to monoclonal antibodies to specific epitopes of the prame and ssx-2 antigens and methods of using such antibodies..
Novel mycorrhizae-based biofertilizer compositions & mass production & formulations of same
This invention relates generally to the field of compositions and methods for developing biofertilizers of organic origin and mycorrhizal origin in particular. The invention focuses on the isolation and characterization of the various formulations and ensuing compositions developed thereof from the arbuscular mycorrhizal fungal propagules whose benefit in crop productivity is well known.
The Energy And Resources Institute (teri)
Melanogenesis-inhibitory constituents of ligusticum sinense
Melanogenesis-inhibitory constituents of ligusticum sinense are disclosed. The melanogenesis-inhibitory constituents can be compound i, ii, or iii having the chemical structures as follow, respectively..
Melanocortin-1 receptor-specific cyclic peptides
Where r1, r2, r3, r4, r5, r6, r7, r8 and r9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.. .
Methods and compositions for oral administration of melanocortin receptor agonist compounds
Methods and compositions for oral administration of melanocortin receptor agonist compounds are disclosed herein. Methods and compositions for oral administration of melanocortin receptor agonist compounds are provided for treatment of sexual dysfunction, including male sexual dysfunction and female sexual dysfunction.
Xion Pharmaceuticals Corporation
Method of treating a malignancy in a subject and a pharmaceutical composition for use in same
There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the picornaviridae family.
Niacin-peptide having skin whitening activity and use for same
Provided is niacin-peptide which has skin whitening activity. The peptide of the present invention has skin whitening activity by inhibiting melanogenesis, that is, by inhibiting the expression of a gene related to melanogenesis (for example, trp-1, trp2, or mift).
A & Pep Inc.
Devices and methods for prognosis prediction for melanoma cancer
The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers.
Ludwig Institute For Cancer Research
Benzopyran compounds as melanogenesis modifiers and uses thereof
Wherein r3, r4, r5, r6, r7 and r8 are described herein. Also provided are plant extracts containing a compound of formula i, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation.
Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of lung cancer, adrenal cancer, melanoma, colon cancer, colorectal cancer, ovarian cancer, prostate cancer, liver cancer, subcutaneous cancer, squamous cell cancer, intestinal cancer, hepatocellular carcinoma, retinoblastoma, cervical cancer, glioma, breast cancer and pancreatic cancer in subject using phospholipid ether analogs.. .
System and optical detection of skin disease
An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.. .
The Rockefeller University
Coating compositions having chelant functionality
The present invention provides a floor coating composition comprising (a) and aqueous solvent; and (b) a chelating polymer which comprises units derived from one or more aminocarboxylate compounds or their salts, one or more other polymerizable monomers, one or more ethylenically unsaturated monomers and, optionally, one or more crosslinking monomers. For example, the aminocarboxylate compounds or their salts may be one or more of iminodiacetic acid (ida), iminodisuccinic acid (ids), ethylenediamine triacetic acid (ed3a) and ethylenediamine disuccinic acid (edds), or their salts.
Rohm And Haas Company
Fish protein hydrolysate having a satietogenic activity, nutraceutical and pharmacological compositions comprising such a hydrolysate and obtaining same
The present invention relates to a fish protein hydrolysate containing molecules capable of exerting a satietogenic activity and of regulating food intake in humans or animals. More specifically, the protein hydrolysate according to the invention enables stimulation of the secretion of endogenous cholescystokinins (ccks) and of endogenous glucagon-like peptide 1 (glp1) molecules by intestinal cells and the supply of exogenous ccks.
Museum National D'histoire
Treatment and diagnosis of melanoma
The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods..
The Rockefeller University
Antiviral drugs for treatment of arenavirus infection
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed.
Siga Technologies Inc.
Treatment for melanoma
The present invention relates to combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include mek inhibitors combination with cardiac glycosides..
The Board Of Regents Of The University Of Texas System
Methods of parkinsons disease diagnosis and monitoring treatment
Embodiments of the present disclosure provide for methods of using labeled probes, methods of diagnosing parkinson's disease and related biological events, methods of using labeled probes for monitoring and/or assessing parkinson's disease treatment, methods of using labeled probes for diagnosing, monitoring, and/or assessing diseases with aberrant melanin-expression, and the like.. .
The Board Of Trustees Of The Leland Stanford Junior University
Positive allosteric modulators for melanocortin receptors
Positive allosteric modulators of melanocortin receptors, especially allosteric potentiators of the receptors mc3r and mc4r are described herein. Also provided are pharmaceutical compositions containing the positive allosteric modulators and methods of treating obesity or an obesity-related disorder such as type 2 diabetes, comprising administering an effective amount of the positive allosteric modulator..
Anti-tumor activity of reduced folates like methylene-tetrahydrofolate
The present invention relates to methylene-tetrahydrofolate for use in the treatment of cancer, based on its intrinsic antitumor activity. The cancers that may be treated include breast cancer, gastric cancer, gastrointestinal cancer, gall bladder cancer, bile duct cancer, colon cancer, rectal cancer, liver cancer, pancreatic cancer, head and neck cancer, esophageal cancer, mesothelioma cancer, lung cancer including non-small-cell lung cancer, ovarian cancer, endometrial cancer, cervical cancer, peripheral cell lymphoma (ptcl), melanoma, brain tumors, adenocarcinoma, esophageal cancer, and osteosarcoma..
Isofol Medical Ab
Methods of improving behavioral therapies
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of psychotherapeutic or social disorders such as autism, and in particular the use of these compounds as an adjunct to psychotherapeutic counseling or behavioral therapy.. .
Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof and microtubule inhibiting herbicides
Or an agriculturally acceptable salt or ester thereof and (b) microtubule inhibiting herbicide, e.g., dimethenamid, s-dimethenamid, and propyzamide, or derivatives thereof. The methods and compositions provided herein provide control of undesirable vegetation, e.g., in direct-seeded, water-seeded and transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn or maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management and rights-of-way..
Tetrahydrofolates in combination with egfr-inhibitors
The present invention relates a pharmaceutical composition comprising an egfr inhibitor and methylene-tetrahydrofolate, tetrahydrofolate or methyl-tetrahydrofolate, for use in the treatment of cancer. The methylene-tetrahydrofolate, tetrahydrofolate or methyl-tetrahydrofolate enhances the anticancer efficacy of the egfr inhibitor.
Isofol Medical Ab
Hydrophilic macromers and hydrogels comprising the same
Wherein r1, r2, r3 r4, r5 and r6 are independently selected from a monovalent linear, branched, or cyclic radical with 1 to 50 carbon atoms, that can optionally contain a heteroatom or i; i is rl-rp; y is a free radical polymerization-effective hydrophilic group with the general structure:rl-rp—z; rl is a linking residue from a non-isomerizable hydrosilylation effective terminal olefin comprising the general structure —ch2—c(rbr7)—(cr8r9)m, the subscript n is selected from integers from 1 to 10; r7, r8, and r9 can be selected from hydrogen and a mono-valent hydrocarbon radical with 1 to 10 carbon atoms that optionally contain a heteroatom; rb is selected from a monovalent hydrocarbon radical with 1 to 6 carbon atoms; rp is a spacer group comprising a diavelant hydrophilic organic radical with 0 to 100 carbon atoms and optionally contains heteroatoms, and x is a free radical polymerizable group. The said composition can be polymers and films suitable for use in making contact lenses..
Method for treating non-melanoma skin cancer by inducing udp-glucuronosyltransferase activity using pterostilbene
A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the compound pterostilbene wherein udp-glucuronosyltransferase (ugt) activity is increased. In an embodiment, 12-hete levels can be reduced by administration of pterostilbene..
Substitute diphenylamine compounds use thereof as antitumor agents
The compound represented by formula (i) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer..
Use of microrna molecules to influence skin pigmentation
At least one microrna selected from among hsa-mir-330, hsa-mir-7 and hsa-mir-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microrna selected from among mir-330, mir-7 and mir-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the micrornas is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.. .
Centre National De La Recherche Scientifique - Cnrs
Diagnosis of melanoma by nucleic acid analysis
The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin.
Use of danielone and derivatives thereof in skin care
The present invention relates to a novel composition comprising danielone and derivatives thereof as well as to the use of such compositions in skin lightening. More particularly, the present invention relates to danielone and derivatives thereof for use in topical compositions for smoothening skin color irregularities, for reducing melanin formation in the human skin, for lightening/brightening human skin and/or for treatment of pigmentation disorders which comprises topically administering an effective amount of danielone and derivatives thereof to the appropriate skin area of a person in need of such beautifying agent, or treatment..
Dsm Ip Assets B.v.
Method for deployable rapid on-site manufacturing using 3d printing in combination with vacuum metallization
Deployable on-site manufacturing using 3d printing is a low cost approach to manufacturing any of thousands of designs at any location. Crowd-sourcing populates a large library of models that can be produced using a small set of standard parts and 3d printed components, as well as highly specialized products.
Method and treating subcutaneous histological features
A system and method for treating subcutaneous histological features without affecting adjacent tissues adversely employs microwave energy of selected power, frequency and duration to penetrate subcutaneous tissue and heat target areas with optimum doses to permanently affect the undesirable features. The frequency chosen preferentially interacts with the target as opposed to adjacent tissue, and the microwave energy is delivered as a short pulse causing minimal discomfort and side effects.
Lkb1/stk11 deletion in melanoma and related methods
Lkb1 mutation status and/or expression, yes expression and phosphorylation level; and/or cd24 expression are employed to predict melanoma prognosis and response to therapeutics. Inhibitors (including targeted inhibitors) of src family kinases (especially yes) are employed to treat melanoma..
Dana-farber Cancer Institute, Inc.
Uses of bremelanotide in therapy for female sexual dysfunction
Use of a subcutaneously administered dose of between about 1.0 mg and 1.75 mg of bremelanotide or a pharmaceutically acceptable salt of bremelanotide for the treatment of female sexual dysfunction in women while reducing or minimizing undesirable side effects.. .
Palatin Technologies, Inc.
T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
The invention provides an isolated or purified t cell receptor (tcr) having antigenic specificity for a) melanoma antigen family a (mage a)-3 in the context of hla-a1 or b) mage-a12 in the context of hla-cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells.
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
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Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph
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