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|| List of recent Elan-related patents
| Devices and methods for prognosis prediction for melanoma cancer|
The invention relates to prognostic markers and prognostic signatures, and compositions and methods for determining the prognosis of cancer in a patient, particularly for melanoma. Specifically, the invention relates to the use of genetic and protein markers for the prediction of the risk of progression of a cancer, such as melanoma, based on markers and signatures of markers.
Ludwig Institute For Cancer Research
| Benzopyran compounds as melanogenesis modifiers and uses thereof|
Wherein r3, r4, r5, r6, r7 and r8 are described herein. Also provided are plant extracts containing a compound of formula i, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation.
| Phospholipid ether analogs as agents for detecting and locating cancer, and methods thereof|
The present invention provides methods for treating, detecting and locating recurrence of cancer, radiation and chemo insensitive cancer or metastasis of cancer selected from the group consisting of lung cancer, adrenal cancer, melanoma, colon cancer, colorectal cancer, ovarian cancer, prostate cancer, liver cancer, subcutaneous cancer, squamous cell cancer, intestinal cancer, hepatocellular carcinoma, retinoblastoma, cervical cancer, glioma, breast cancer and pancreatic cancer in subject using phospholipid ether analogs.. .
|System and optical detection of skin disease|
An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.. .
The Rockefeller University
|Coating compositions having chelant functionality|
The present invention provides a floor coating composition comprising (a) and aqueous solvent; and (b) a chelating polymer which comprises units derived from one or more aminocarboxylate compounds or their salts, one or more other polymerizable monomers, one or more ethylenically unsaturated monomers and, optionally, one or more crosslinking monomers. For example, the aminocarboxylate compounds or their salts may be one or more of iminodiacetic acid (ida), iminodisuccinic acid (ids), ethylenediamine triacetic acid (ed3a) and ethylenediamine disuccinic acid (edds), or their salts.
Rohm And Haas Company
|Fish protein hydrolysate having a satietogenic activity, nutraceutical and pharmacological compositions comprising such a hydrolysate and obtaining same|
The present invention relates to a fish protein hydrolysate containing molecules capable of exerting a satietogenic activity and of regulating food intake in humans or animals. More specifically, the protein hydrolysate according to the invention enables stimulation of the secretion of endogenous cholescystokinins (ccks) and of endogenous glucagon-like peptide 1 (glp1) molecules by intestinal cells and the supply of exogenous ccks.
Museum National D'histoire
|Treatment and diagnosis of melanoma|
The present invention discloses novel agents and methods for diagnosis and treatment of melanoma. Also disclosed are related arrays, kits, and screening methods..
The Rockefeller University
|Antiviral drugs for treatment of arenavirus infection|
Compounds, methods and pharmaceutical compositions for treating viral infections, by administering certain compounds in therapeutically effective amounts are disclosed. Methods for preparing the compounds and methods of using the compounds and pharmaceutical compositions thereof are also disclosed.
Siga Technologies Inc.
|Treatment for melanoma|
The present invention relates to combination therapies for melanoma, and in particular, metastatic melanoma. Drugs for use in such therapies in include mek inhibitors combination with cardiac glycosides..
The Board Of Regents Of The University Of Texas System
|Methods of parkinsons disease diagnosis and monitoring treatment|
Embodiments of the present disclosure provide for methods of using labeled probes, methods of diagnosing parkinson's disease and related biological events, methods of using labeled probes for monitoring and/or assessing parkinson's disease treatment, methods of using labeled probes for diagnosing, monitoring, and/or assessing diseases with aberrant melanin-expression, and the like.. .
The Board Of Trustees Of The Leland Stanford Junior University
Positive allosteric modulators for melanocortin receptors
Positive allosteric modulators of melanocortin receptors, especially allosteric potentiators of the receptors mc3r and mc4r are described herein. Also provided are pharmaceutical compositions containing the positive allosteric modulators and methods of treating obesity or an obesity-related disorder such as type 2 diabetes, comprising administering an effective amount of the positive allosteric modulator..
Anti-tumor activity of reduced folates like methylene-tetrahydrofolate
The present invention relates to methylene-tetrahydrofolate for use in the treatment of cancer, based on its intrinsic antitumor activity. The cancers that may be treated include breast cancer, gastric cancer, gastrointestinal cancer, gall bladder cancer, bile duct cancer, colon cancer, rectal cancer, liver cancer, pancreatic cancer, head and neck cancer, esophageal cancer, mesothelioma cancer, lung cancer including non-small-cell lung cancer, ovarian cancer, endometrial cancer, cervical cancer, peripheral cell lymphoma (ptcl), melanoma, brain tumors, adenocarcinoma, esophageal cancer, and osteosarcoma..
Isofol Medical Ab
Methods of improving behavioral therapies
This disclosure provides methods of using compounds that act to increase oxytocin release, including certain melanocortin receptor agonists, for treating or reducing the severity of psychotherapeutic or social disorders such as autism, and in particular the use of these compounds as an adjunct to psychotherapeutic counseling or behavioral therapy.. .
Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylic acid or a derivative thereof and microtubule inhibiting herbicides
Or an agriculturally acceptable salt or ester thereof and (b) microtubule inhibiting herbicide, e.g., dimethenamid, s-dimethenamid, and propyzamide, or derivatives thereof. The methods and compositions provided herein provide control of undesirable vegetation, e.g., in direct-seeded, water-seeded and transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn or maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management and rights-of-way..
Tetrahydrofolates in combination with egfr-inhibitors
The present invention relates a pharmaceutical composition comprising an egfr inhibitor and methylene-tetrahydrofolate, tetrahydrofolate or methyl-tetrahydrofolate, for use in the treatment of cancer. The methylene-tetrahydrofolate, tetrahydrofolate or methyl-tetrahydrofolate enhances the anticancer efficacy of the egfr inhibitor.
Isofol Medical Ab
Hydrophilic macromers and hydrogels comprising the same
Wherein r1, r2, r3 r4, r5 and r6 are independently selected from a monovalent linear, branched, or cyclic radical with 1 to 50 carbon atoms, that can optionally contain a heteroatom or i; i is rl-rp; y is a free radical polymerization-effective hydrophilic group with the general structure:rl-rp—z; rl is a linking residue from a non-isomerizable hydrosilylation effective terminal olefin comprising the general structure —ch2—c(rbr7)—(cr8r9)m, the subscript n is selected from integers from 1 to 10; r7, r8, and r9 can be selected from hydrogen and a mono-valent hydrocarbon radical with 1 to 10 carbon atoms that optionally contain a heteroatom; rb is selected from a monovalent hydrocarbon radical with 1 to 6 carbon atoms; rp is a spacer group comprising a diavelant hydrophilic organic radical with 0 to 100 carbon atoms and optionally contains heteroatoms, and x is a free radical polymerizable group. The said composition can be polymers and films suitable for use in making contact lenses..
Method for treating non-melanoma skin cancer by inducing udp-glucuronosyltransferase activity using pterostilbene
A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the compound pterostilbene wherein udp-glucuronosyltransferase (ugt) activity is increased. In an embodiment, 12-hete levels can be reduced by administration of pterostilbene..
Substitute diphenylamine compounds use thereof as antitumor agents
The compound represented by formula (i) showed potent antitumor activity, especially to cure or alleviate the cancer causing by cancer cells of human tissue or organ. The preferred cancers are: colon cancer, liver cancer, lymph cancer, lung cancer, esophageal cancer, breast cancer, central nervous system cancer, melanoma, ovarian cancer, cervical cancer, renal cancer, leukemia, prostatic cancer, pancreatic cancer, bladder cancer, rectal cancer, osteosarcoma, nasopharynx cancer or stomach cancer..
Use of microrna molecules to influence skin pigmentation
At least one microrna selected from among hsa-mir-330, hsa-mir-7 and hsa-mir-137, the mature forms thereof, and the precursors thereof, for depigmenting the skin, and an in vitro method for identifying depigmenting compounds, which includes the steps of: a) placing at least one test compound in contact with a sample of melanocytes; b) measuring the expression or activity of at least one microrna selected from among mir-330, mir-7 and mir-137, the mature forms thereof, and the precursors thereof, in the melanocytes; c) selecting the compounds for which at least 20% activation of the expression or of the activity of at least one of the micrornas is measured in the melanocytes treated in a) by an element for comparing with the untreated melanocytes.. .
Centre National De La Recherche Scientifique - Cnrs
Diagnosis of melanoma by nucleic acid analysis
The present invention provides methods for diagnosing melanoma and/or solar lentigo in a subject by analyzing nucleic acid molecules obtained from the subject. The present invention also provides methods for distinguishing melanoma from solar lentigo and/or dysplastic nevi and/or normal pigmented skin.
Use of danielone and derivatives thereof in skin care
The present invention relates to a novel composition comprising danielone and derivatives thereof as well as to the use of such compositions in skin lightening. More particularly, the present invention relates to danielone and derivatives thereof for use in topical compositions for smoothening skin color irregularities, for reducing melanin formation in the human skin, for lightening/brightening human skin and/or for treatment of pigmentation disorders which comprises topically administering an effective amount of danielone and derivatives thereof to the appropriate skin area of a person in need of such beautifying agent, or treatment..
Dsm Ip Assets B.v.
Method for deployable rapid on-site manufacturing using 3d printing in combination with vacuum metallization
Deployable on-site manufacturing using 3d printing is a low cost approach to manufacturing any of thousands of designs at any location. Crowd-sourcing populates a large library of models that can be produced using a small set of standard parts and 3d printed components, as well as highly specialized products.
Method and treating subcutaneous histological features
A system and method for treating subcutaneous histological features without affecting adjacent tissues adversely employs microwave energy of selected power, frequency and duration to penetrate subcutaneous tissue and heat target areas with optimum doses to permanently affect the undesirable features. The frequency chosen preferentially interacts with the target as opposed to adjacent tissue, and the microwave energy is delivered as a short pulse causing minimal discomfort and side effects.
Lkb1/stk11 deletion in melanoma and related methods
Lkb1 mutation status and/or expression, yes expression and phosphorylation level; and/or cd24 expression are employed to predict melanoma prognosis and response to therapeutics. Inhibitors (including targeted inhibitors) of src family kinases (especially yes) are employed to treat melanoma..
Dana-farber Cancer Institute, Inc.
Uses of bremelanotide in therapy for female sexual dysfunction
Use of a subcutaneously administered dose of between about 1.0 mg and 1.75 mg of bremelanotide or a pharmaceutically acceptable salt of bremelanotide for the treatment of female sexual dysfunction in women while reducing or minimizing undesirable side effects.. .
Palatin Technologies, Inc.
T cell receptors recognizing hla-a1- or hla-cw7-restricted mage
The invention provides an isolated or purified t cell receptor (tcr) having antigenic specificity for a) melanoma antigen family a (mage a)-3 in the context of hla-a1 or b) mage-a12 in the context of hla-cw7. The invention further provides related polypeptides and proteins, as well as related nucleic acids, recombinant expression vectors, host cells, and populations of cells.
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
Skin-whitening composition containing extracts from trees including paper mulberry
Disclosed is a skin-whitening composition comprising a paper mulberry extract, and more particularly to a skin-whitening composition containing an extract of acer barbinerve max., acer barbinervis var. Glabrescens, wikstroemia trichotoma, acer tschonoskii var.
Methods and compositions for alteration of skin pigmentation
Compositions are provided that possess levels of phytic acid and optionally a hydroxy acid and/or azelaic acid that act synergistically with the phytic acid to reduce melanin levels in skin. Improved reduction in melanin levels and hyperpigmentation are achieved at low levels of azelaic acid and phytic acid such that greater comfort and reduced irritation are observed at an administration site.
Diarylalkanes as potent inhibitors of binuclear enzymes
The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction.
Methods for producing hair microfollicles and de novo papillae and their use for in vitro tests and in vivo implantations
The present invention relates to a method for producing hair microfollicles comprising the steps of: a) providing de novo papillae, b) providing other cell populations selected from the group of fibroblasts, keratinocytes and melanocytes, and co-culturing the de novo papillae with at least one other cell population in non-adherent culture vessels. The present invention relates also to methods of producing de novo papillae usable in said method for producing hair microfollicles..
Technische Universitat Berlin
Piv5 as oncolytic agent
The present invention includes the paramyxovirus parainfluenza virus 5 (piv5) as an oncolytic agent for treating various cancers, including, but not limited to breast cancer, lung cancer and melanoma. Piv5 oncolytic agents include both wild type piv5 and various recombinant piv5 constructs.
University Of Georgia Research Foundation, Inc.
Chelating system for a polymer lined steel container
A chelating system for inclusion in a composition at least stored in a polymer lined metal passivated steel container which provides for stability of both the composition and the container. The composition preferably is a cleaning composition including a color-changing dye or indicator.
S.c. Johnson & Son, Inc.
Agents for enhanced degradation of controlled electrolytic material
A method for degrading a downhole article includes exposing the downhole article comprising a controlled electrolytic material to a composition that comprises a reducing agent. The method also includes contacting the downhole article with the reducing agent to degrade the downhole article.
Baker Hughes Incorporated
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of growth/differentiation factor 2, catalase, vascular endothelial growth factor c, and melanoma-derived growth regulatory protein as diagnostic and prognostic biomarkers in renal injuries..
Chloride, bromide and iodide scintillators with european doping
A halide scintillator material is disclosed where the halide may comprise chloride, bromide or iodide. The material is single-crystalline and has a composition of the general formula abx3 where a is an alkali, b is an alkali earth and x is a halide which general composition was investigated.
Melanin production inhibitor
Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof.
Series of skin whitening (lightening) compounds
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin..
Methods for producing melanin and inorganic fertilizer from fermentation leachates
Melanin or inorganic fertilizers are produced from fermentation leachates or from low-cost nutrient-rich solutions. The method for producing the melanin or inorganic fertilizer comprises repetitive trophic cycling in the controlled conditions of primary and secondary bioreactors.
Melanocortin receptor-specific heptapeptides
Or a pharmaceutically acceptable salt thereof, where z, xaa1, xaa2, xaa3, xaa4, xaa5, xaa6, xaa7 and y are as defined in the specification, compositions and formulations including the peptides of the foregoing formula, and methods of preventing, ameliorating or treating melanocortin receptor-mediated diseases, indications, conditions and syndromes.. .
Cell phone case with templates for photograph collage or melange
A protective case for an electronic device comprises a main frame with clear display panel as collage template to be able to display photographs and/or artworks. In one embodiment, the clear display panel is removable and interchangeable; so that the user has the flexibility of changing to a different display panel which serves as the collage template, therefore, the user is able to display their favorite photographs and/or artworks at their own convenience..
Composition containing paper mulberry extracts
Disclosed is a use of a composition containing a paper mulberry extract, and more particularly to a use of a composition containing, as an active ingredient, a paper mulberry extract in enhancement of skin moisturization, inhibition of skin aging, alleviation of inflammation, antibacterial activity, pore size reduction, sebum control, skin complexion improvement, decomposition of subcutaneous fat, stimulation of melanin synthesis, and gray hair prevention.. .
Probes, methods of making probes, and methods of use
Embodiments of the present disclosure provide for water soluble polyethylene glycol (peg)-polymeric melanin (peg-melanin) nanoparticles, methods of using the peg-melanin nanoparticle, methods of making the peg-melanin nanoparticle, methods of imaging a diseases or condition (e.g., pre-cancerous tissue, cancer, or a tumor), and the like. Embodiments of the present disclosure can be used in multimodal imaging (e.g., photoacoustic, nuclear, magnetic, fluorescent, and the like)..
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Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph
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