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|| List of recent Elan-related patents
| Factors controlling skin and hair color|
Use of autophagic activity in regulation of the amount of melanin in a keratinocyte, the control of skin or hair color, or selection of an agent for regulating the amount of melanin in a keratinocyte or an agent for controlling skin or hair color.. .
|Investigation reporting system with freelancer input option|
A system distributes instructions from a central server to repossession agents through a smart-phone application that is in networked communication with the central server, and the repossession agents report information back to the central server through the smart-phone application. The smart-phone application can also be used by freelancers to provide suspect vehicle information to the central server.
|Methods and apparatuses for noninvasive determination of in vivo alcohol concentration using raman spectroscopy|
Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined.
|Synergistic interaction of at least one vitamin e component and tyrosinase inhibitors for dermatological applications|
The present invention is directed to a method of treating a dermatological condition or preventing a dermatological condition from occurring or for altering the pigmentation of the skin by administering to a patient a pharmaceutically effective amount of a composition comprising at least one vitamin e component and at least one additional component different from the vitamin e component that has anti-tyrosinase activity and/or anti-melanogenesis activity. The present invention is further directed to a pharmaceutical composition comprising at least one vitamin e component and at least one additional component different from the vitamin e component that has anti-tyrosinase activity and/or anti-melanogenesis activity..
|Novel purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative, pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition with inhibitory activity against raf kinase, containing same as active ingredient|
A novel purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative, a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutical composition with an inhibitory activity against raf kinase, containing the same as an active ingredient are provided. The purinylpyridinylamino-2,4-difluorophenyl sulfonamide derivative of the present invention effectively regulates the activity of b-raf kinase, and thus may be useful for preventing or treating cancers induced by the over-activation of raf kinase, especially various melanoma, colorectal cancer, prostate cancer, thyroid cancer, ovarian cancer and the like..
|Markers of melanoma and uses thereof|
The invention relates to a method for determining prognosis, predicting or monitoring response to therapy of patients affected by melanoma through the evaluation of the methylation of different genomic dna sequences, including the long interspersed nucleotide element-1 (line-1) repetitive dna sequences and/or the concomitant methylation profile of specific groups of genes defined as methylation signature.. .
|Methods and compositions for assessing and treating cancer|
The invention relates to methods and compositions for identifying mutations associated with cancer, such as melanoma. More particularly, the invention relates to methods and compositions for assessing particular mutations as markers for cancer, such as melanoma.
|Wireless tracking and monitoring electronic seal|
An electronic security seal (e-seal) is disclosed. The e-seal monitors security of shipments including intermodal containers, reports tampers in real-time, monitors environmental status of goods and reports exceptions in real-time, and reports the location of the shipment with high frequency.
|Treatment fluid and method|
A treatment fluid made of mineral acid, viscoelastic surfactant, at least one of a fluoride source and a chelant, and optionally a corrosion inhibitor. A method of combining a mineral acid, viscoelastic surfactant, at least one of a fluoride source and a chelant, and optionally a corrosion inhibitor, in a fluid mixture.
|Herbicidal compositions comprising 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl) pyridine-2-carboxylic acid or a derivative thereof and vlcfa and lipid synthesis inhibiting herbicides|
Or an agriculturally acceptable salt or ester thereof and (b) vlcfa and fatty acid/lipid synthesis inhibiting herbicides, including but not limited to, acetochlor, alachlor, anilofos, benfuresate, cafenstrole, dimethenamid-p, fentrazamide, indanofan, flufenacet, mefenacet, s-metolachlor, molinate, pethoxamid, pretilachlor, prosulfocarb, pyroxasulfone, thenylchlor and thiobencarb, or a salt or ester thereof, provide synergistic weed control of undesirable vegetation in direct-seeded, water-seeded and transplanted rice, cereals, wheat, barley, oats, rye, sorghum, corn or maize, sugarcane, sunflower, oilseed rape, canola, sugar beet, soybean, cotton, pineapple, pastures, grasslands, rangelands, fallowland, turf, tree and vine orchards, aquatics, plantation crops, vegetables, industrial vegetation management (ivm) or rights-of-way (row).. .
|Trrap and grin2a mutations and use thereof for the diagnosis and treatment of melanoma|
Described herein is the identification of 68 genes with an elevated frequency of somatic mutations in melanoma. Nine genes were identified that exhibited recurring mutations in melanoma.
|Skin-whitening agent containing 3-hydroxy-2-pyrone|
This invention provides a skin-whitening agent, a tyrosinase activity inhibitor, and melanin production inhibitor comprising, as an active ingredient, a compound exhibiting excellent solubility in various solvents. Such skin-whitening agent, tyrosinase activity inhibitor, and melanin production inhibitor comprise 3-hydroxy-2-pyrone..
|External composition for skin containing manassantin b as active ingredient and the use thereof for skin whitening|
Disclosed herein are an external composition for skin, which contains, as an active ingredient, manassantin b extracted from saururus chinensis baill, and the use thereof for skin whitening. More particularly, disclosed are an external composition for skin, which contains, as an active ingredient, manassantin b, which inhibits the transfer of melanosomes, thus providing a skin-whitening effect without influencing the melanin synthesis function of the melanocytes, as well as the use thereof for skin whitening..
|Peptide analogs of alpha-melanocyte stimulating hormone|
Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (α-msh) having selectivity for the melanocortin 1 receptor (mc1r). Also provided herein are pharmaceutical preparations of the α-msh peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving mc1r..
|Label removal solution for returnable beverage bottles|
According to the invention, the compositions and methods provide for the complete removal of synthetic glues or adhesives from a plurality of surfaces through the use of organic solvents and/or amine solvents in combination with surfactants, chelants, acidulants and/or additional bottle wash additives. Beneficially, the compositions and methods are suitable for use at lower temperatures and ph conditions that conventional caustic-based adhesive removal compositions..
|Zeaxanthin for tumor treatment|
A composition comprising a pharmaceutically effective amount of zeaxanthin or its derivative for use in treating a malignant tumor and a method of using a pharmaceutically effective amount of zeaxanthin or its derivative either alone or together with one or more pharmaceutical agents for treating a malignant tumor. The tumor may be, but is not limited to breast cancer, cervix cancer, colon cancer, cutaneous melanoma, cutaneous squamous carcinoma, hepatocellular carcinoma, lung cancer, osteosarcoma, prostate cancer, and uveal melanoma.
|B and t lymphocyte attenuator marker for use in adoptive t-cell therapy|
Btla-positive (“btla+”) lymphocyte signaling drives t cells and kills tumors. Btla functions as a positive modulator of anti-tumor (anti-melanoma) t cell responses, the btla+ t cell responds against tumor or cancer cells, and, in cancer patients respond better to il-2 than btla-negative cells.
|Topical composition and method for skin lightening|
A topical cosmetic composition for skin whitening or skin lightening is described. The composition includes an aqueous extract of caesalpinia spinosa, also known as tara, in an amount effective to reduce melanin production.
|Indole alkaloid compounds as melanogenesis promoters and uses thereof|
Also provided are plant extracts containing a compound of formula i, for example, pubescine, and the use of such a plant extract to promote (e.g., enhance) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity..
|Melanocortin-1 receptor-specific cyclic peptides|
Where r1, r2, r3, r4, r5, r6, r7, r8 and r9 are as defined in the specification, compositions and formulations including the peptides of the foregoing formula or salts thereof, and methods of preventing, ameliorating or treating melanocortin-1 receptor-mediated or responsive diseases, indications, conditions and syndromes.. .
|Muc18 targeting peptides|
Provided are muc18 targeting peptides which may be used, e.g., to therapeutically target b-1 lymphocytes to reduce the influence of these cells on the metastatic potential of melanoma cells and/or to target cancerous cells, including certain melanoma and leukemia cells. Muc18 targeting peptides may be comprised in fusion constructs, imaging constructs, and/or therapeutic constructs such as fusion constructs which may be used for diagnosing or treating a cancer..
|Skin whitening agent|
Use of haguro-so or an organic solvent extract thereof, or a compound represented by the following formula (i) or a salt thereof, for inhibiting a dopa oxidase activity, for inhibiting melanin production, or for whitening the skin; in the formula (i), r1 and r2, being the same or different, each represent a hydroxyl group, or a c1-4 linear or branched alkoxy group, or r1 and r2 together form a methylenedioxy group; r3 and r4, being the same or different, each represent a hydroxyl group, or a c1-4 linear or branched alkoxy group, or r3 and r4 together form a methylenedioxy group; r5 represents a hydrogen atom, a hydroxyl group, a c1-5 linear or branched alkoxy group, a c1-4 acyl group, or a sugar residue selected from the group consisting of (d-apio-β-d-furanosyl)oxy, (β-d-glucopyranosyl)oxy, (3-o,4-o-dimethyl-d-xylopyranosyl)oxy, (2-o,3-o,4-o-trimethyl-β-d-xylopyranosyl)oxy, and (3-o-methyl-β-d-glucopyranosyl)oxy; r6 and r7 are each a hydrogen atom and r8 and r9 together represent an oxygen atom, or r8 and r9 are each a hydrogen atom and r6 and r7 together represent an oxygen atom.. .
|Melanocortin receptor-specific peptides for treatment of female sexual dysfunction|
Where r, x and y are as defined in the specification, and compositions and formulations including the peptide of the foregoing formula, for preventing, ameliorating or treating female sexual dysfunction.. .
|Device for performing a photoelectrochemical method of separating water into hydrogen and oxygen|
The invention is directed to a system for hydrogen production from water, known as a photoelectrochemical system. The system integrates a semiconductor material and a water electrolyzing material inside a monolithic design, to produce hydrogen directly from water.
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Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph
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