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Elan patents



      

This page is updated frequently with new Elan-related patent applications.




Date/App# patent app List of recent Elan-related patents
04/07/16
20160096841 
 Substituted aminopurine compounds, compositions thereof, and methods of treatment therewith patent thumbnailSubstituted aminopurine compounds, compositions thereof, and methods of treatment therewith
Wherein r1, r2, and r3 are as defined herein, compositions comprising an effective amount of an aminopurine compound, and methods for treating or preventing a cancer, for example, melanoma.. .

04/07/16
20160096825 
 Furanone compounds as kinase inhibitors patent thumbnailFuranone compounds as kinase inhibitors
The present disclosure provides novel furanone compounds, or pharmaceutically acceptable salts, solvates or prodrugs thereof, as raf kinase, especially braf kinase, inhibitors, which are useful therapeutic agents for treatment of raf kinase related diseases or disorders, such as melanomas, cancers, and leukemia. The disclosure also provides methods and processes for preparing these novel furanone compounds, pharmaceutical compositions containing these furanone compounds, and methods of treatment using these furanone compounds..
Eternity Bioscience Inc.


04/07/16
20160096823 
 Aminopyridyloxypyrazole compounds patent thumbnailAminopyridyloxypyrazole compounds
The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (tgfβr1), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.. .
Eli Lilly And Company


03/31/16
20160094965 
 Access to wireless emergency alert information via the spectrum access system patent thumbnailAccess to wireless emergency alert information via the spectrum access system
The spectrum access system (sas) may be utilized wireless emergency alert (wea) information. The sas may be utilized to retrieve additional wea information, beyond that which was provided in a wea message.
At&t Intellectual Property I, L.p.


03/31/16
20160092723 
 Elapsed-time determination apparatus, deciding apparatus, deciding method, and non-transitory computer-readable recording medium storing control program patent thumbnailElapsed-time determination apparatus, deciding apparatus, deciding method, and non-transitory computer-readable recording medium storing control program
An elapsed-time determination apparatus includes: a storage unit that stores correlation information indicating a correlation between a state of a melanophore of a fish and an amount of time elapsed since the death of the fish; an acquisition unit that acquires an image of a fish; an analysis unit that detects a state of a melanophore of a fish by analyzing an image acquired by the acquisition unit; and a determination unit that determines the amount of time elapsed since the death of the fish in accordance with the state of the melanophore of the fish detected by the analysis unit, based on the correlation information, and outputs determination results.. .
Panasonic Corporation


03/31/16
20160089319 
 Actives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin patent thumbnailActives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin
A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin..
Elc Management Llc


03/24/16
20160083379 
 Histone demethylase inhibitors patent thumbnailHistone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


03/24/16
20160083322 
 Series of skin-whitening (lightening) compounds patent thumbnailSeries of skin-whitening (lightening) compounds
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin..
Unigen, Inc.


03/24/16
20160082024 
 Use of pentacyclic triterpenoid saponin compound from szechuan melandium root for preparing hypoglycemic drug patent thumbnailUse of pentacyclic triterpenoid saponin compound from szechuan melandium root for preparing hypoglycemic drug
The application of pentacyclic triterpenoid saponins, extracted from the plant of silene viscidula, is used to manufacture anti-diabetic medicaments. Having screened and researched the plants and the compounds massively, the compounds of pentacyclic triterpenoid saponins extracted and purified from silene viscidula (hereinafter called wacao saponnins), have strong effects on hyperglycemia, especially for the compounds that have mother nuclei of sinocrassulosides, which can be used to manufacture anti-diabetic medicaments..

03/17/16
20160077082 
 Compositions and methods for inhibiting hmgb1 activation of melanocytes patent thumbnailCompositions and methods for inhibiting hmgb1 activation of melanocytes
A method of identifying a test agent as a skin tone agent. The method includes determining the level of high-mobility group protein b1 (hmgb1), messenger rna associated with the expression and/or regulation of hmgb1 (hmgb1 mrna), and/or micro-rna associated with the expression and/or regulation of hmgb1 (hmgb1 mirna) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in hmgb1 level, a downregulation in transcription of hmgb1 mrna, and/or an upregulation of hmgb1 mirna.
The Procter & Gamble Company


03/17/16
20160077080 

Method of making a skin care composition


A method of making a skin composition that includes an effective amount of skin care agent selected to inhibit hmgb1 stimulation of human melanocytes. The method includes determining the level of high-mobility group protein b1 (hmgb1), messenger rna associated with the expression and/or regulation of hmgb1 (hmgb1 mrna), and/or micro-rna associated with the expression and/or regulation of hmgb1 (hmgb1 mirna) present in the test sample, and identifying the test agent as a skin tone agent when there is no increase in hmgb1 level, a downregulation in transcription of hmgb1 mrna, and/or an upregulation of hmgb1 mirna.
The Procter & Gamble Company


03/17/16
20160074499 

Anti-inflammatory, skin-regenerative, whitening, antioxidant, or wound-healing composition containing culture medium of adsc-t cells in which t-antigen is introduced into adipose-derived stem cell as active ingredient


The present invention relates to an anti-inflammatory, skin-regenerative, whitening, antioxidant, or wound-healing composition containing a culture medium of adipose-derived stem cell-t (adsc-t) cells as an active ingredient, in which t-antigen is introduced into an adipose-derived stem cell. The culture medium of adsc-t cells, according to the present invention, has remarkable effects for treating or inhibiting inflammation by alleviating atopic dermatitis, which is an autoimmune disease, and inhibiting nf-κb activities through an increase of an iκbα expression.
Changwon National University Industry Academy Cooperation Corps


03/17/16
20160074314 

Topical skin care formulations comprising plant extracts


Disclosed is a method of treating a skin condition, the method comprising topically applying to skin in need thereof a composition comprising an effective amount of an aqueous or alcoholic extract from the leaf of quassia undulata, wherein the composition treats the skin condition by reducing cox-1, lipoxygenase, tyrosinase, tnf-α, melanogenesis, or mmp-1 activity in the skin.. .
Mary Kay Inc.


03/17/16
20160074293 

Cosmetic compositions and methods for inhibiting melanin synthesis


A cosmetic composition suitable for topical application, for example, is provided. In some examples, the cosmetic composition may include bisabolol, undecylenoyl phenylalanine and/or hexyldecanol, and a material selected from the group consisting of ethyl palmitate, stearyl alcohol, bis(2-ethylhexyl)adipate, bis(2-ethylhexyl)maleate, 5-pentadecanol, 1-stearoyl-rac-glycerol, bis(2-ethylhexyl)sebacate, and mixtures thereof.
The Procter & Gamble Company


03/10/16
20160069880 

Proteins


The present invention relates to the identification of membrane proteins associated with b-cell non-hodgkin's lymphoma, breast cancer, cervical cancer, colorectal cancer, gastric cancer, glioblastoma, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute t-cell leukaemia and chronic lymphocytic leukaemia), melanoma, neuroblastoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer, renal cell cancer and retinoblastoma which have utility as markers and for treatment of said cancers and which also form biological targets against which antibodies such as therapeutic antibodies (or other affinity reagents) or other pharmaceutical agents can be made.. .

03/10/16
20160068507 

Histone demethylase inhibitors


Provided herein are substituted pyrazolylpyridine, pyrazolylpyridazine, and pyrazolylpyrimidine derivative compounds and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for inhibition histone demethylase.
Quanticel Pharmaceuticals, Inc.


03/10/16
20160067314 

Compositions and methods for inhibiting chemoresistance in cancer and improving response to therapy


Metastatic melanomas are highly resistant to radiation and chemotherapy from the earliest stages, which is a major factor in poor clinical outcomes. Activated leukocyte adhesion molecule (alcam)/cd166 was the gene that showed the highest correlation with detachment-induced chemoresistance.
University Of Virginia Patent Foundation


03/10/16
20160067240 

Novel allosteric inhibitors of thymidylate synthase


The current invention is directed to a class of compounds that inhibit the function of thymidylate synthase. Thymidylate synthase inhibition was noted to result in inhibition of tumor cell grow and killing of tumor cells.
University Of Florida Research Foundation, Inc.


03/10/16
20160067211 

Pharmaceutical composition


The present invention relates to a pharmaceutical composition for the prophylaxis and/or treatment of a melanoma and a precursor thereof as well as a skin and mucosa metastasis and uses and methods associated therewith.. .
Eberhard Karls Universitaet Tuebingen Medizinische Fakultaet


03/03/16
20160063575 

Content acquisition and conversion system


The technologies presented herein relate to a centralized system for generating media content in response to a job request, particularly for transmission over radio waves. A plurality of individuals can subscribe to the centralized system to review the job request, and based thereon, can provide one or more submissions for potential incorporation into media desired by the job requester.
Wavstar, Llc


03/03/16
20160060343 

Cancer treatment


The present invention relates to methods of treating cancer, such as melanoma, by administering a ctla4 antagonist to a subject with a serum c-reactive protein (crp) concentration that is less than or equal to some amount. The invention further relates to methods of treating cancer by determining the level of serum crp concentration in a subject, and then administering a ctla4 antagonist if the crp concentration is less than or equal to a certain amount.
Pfizer Inc.


03/03/16
20160060247 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted 3-aminopyridine derivative compounds, substituted 3-aminopyridazine derivative compounds, and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


03/03/16
20160060234 

Cysteine derivative


And salts thereof, are superior in stability, have less odor, exhibit an eumelanin production suppressive effect, and are useful as cosmetic agents.. .

03/03/16
20160058288 

Three dimensional tissue imaging system and method


Multispectral digitized images are provided by utilizing 2 or more spectral bands, providing images and information regarding a pigmented or other differentiated tissue sample at differing depths. The images are transformed to enhance morphological patterns characteristic of melanoma, such as the statistical properties of the pigment network, image texture or homogeneity, and the lesion reflectance, in order to provide information about lesion morphology at different depths.
Mela Sciences, Inc.


02/25/16
20160052979 

Family of synthetic polynucleotide-binding peptides and uses thereof


The present invention provides novel synthetic peptides (including the tzip peptide) as oncogenic and genetic modulators, including genetics of viruses, as well as methods of making and using the same. These peptides are useful for inhibiting the proliferation of cancer cells characterized as having amplified c-myc genes.
Eastern Virginia Medical School


02/25/16
20160052915 

Rohitukine analogs as cyclin-dependent kinase inhibitors and a process for the preparation thereof


The present invention relates to the rohitukine (5,7-dihydroxy-8-(3-hydroxy-1-methyl-piperidin-4-yl)-4h-chromen-4-ones) analogs of formula a and pharmaceutically acceptable salts thereof. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various proliferative disorders such as melanoma, leukemia, breast cancer and prostate cancer etc.
Council Of Scientific And Industrial Research


02/25/16
20160051553 

Molecular and herbal combinations with methotrexate for treating diseases and inflammatory ailments


A treatment regimen for psoriasis, eczema or other skin ailment, inflammation, autoimmune disease, leukemia, melanoma or other cancer includes administering to a patient a methotrexate regimen along with periodic doses of an herbal combination including sheng di huang, da huang or jin yin hua or combinations thereof.. .
Sirbal, Ltd.


02/25/16
20160051532 

Method of treating cancer


This invention is directed to the treatment of cancer, particularly ocular melanoma, with a dual inhibitor of met and vegf such as compound 1.. .
Exelixis, Inc.


02/25/16
20160051508 

Use of a macrocyclic lactone for treating a complication from a papilloma virus infection


A compound is described that is selected from among macrocyclic lactones for treating and/or preventing a complication from a human papillomavirus infection. The complication to be treated and/or prevented can be selected from among malignant melanomas, skin carcinomas, in situ or invasive carcinomas, epidermoid carcinomas, bowen's disease, head and neck cancers, upper aerodigestive tract cancers, laryngeal cancers, esophageal cancers, stomach cancers, oral papillomas, pharyngeal papillomas, laryngeal papillomas, esophageal papillomas, lung cancers, intravulval neoplasias, intravaginal neoplasias, intracervical neoplasias, cervical dysplasias, cervical carcinomas, penile cancer, intrapenile neoplasias, and in situ or invasive anal carcinomas..
Galderma Sa


02/25/16
20160051493 

Methods of treatment of keratinocyte-derived lesions


Methods are provided for diagnosing and treating or preventing keratinocyte-derived lesions, e.g., scc, (including high-risk forms), non-melanoma skin cancers (including high-risk forms), and actinic keratinosis (“ak”) by administering a therapeutically effective amount of camphor oil, camphor oil derivatives or components, and certain terpene trpv3 agonists including 2-apb.. .
The Trustees Of Columbia University In The City Of New York


02/25/16
20160051485 

Biodegradable bionanoparticles for releasing the gse24-2 peptide, the production thereof, and use of same


The invention relates to biodegradable plga bionanoparticles encapsulating the gse24-2 peptide with telomerase activity and to pharmaceutical, cosmetic and biotechnological compositions comprising same. The pharmaceutical compositions are useful for treating diseases presenting a telomerase deficiency, such as dyskeratosis congenita, and diseases presenting ageing characteristics, such as werner syndrome, rothmund thompson syndrome, and other diseases where there is dna damage such as ataxia telangiectasia.
Centro De InvestigaciÓ Biomedica En Red De Enfermedades Raras (ciberer)


02/25/16
20160051482 

Process for the preparation of erythrocytes loaded with one or more substances of pharmaceutical interest and so obtained erythrocytes


The present invention relates to a process for preparing erythrocytes loaded with one or more substance of pharmaceutical interest. The present invention is also directed to loaded erythrocytes thus obtained and pharmaceutical compositions comprising said population of loaded erythrocytes as well as therapeutic application thereof, in particular in the treatment of ataxia telangiectasia..
Erydel S.p.a.


02/25/16
20160051462 

Cosmetic or dermatological use of a polygonum bistorta extract


It finally relates to a polygonum bistorta extract or a dermatological composition containing a polygonum bistorta extract and a dermatologically acceptable excipient for topical use in the treatment and/or prevention of rosacea, telangiectasias, chapping and/or disorders of the buccal and/or ocular mucous membranes.. .

02/18/16
20160049262 

Melanins as active components in energy storage materials


In one aspect, an energy storage device comprises one or more organic electrodes comprising one or more melanin-based energy storage materials and cations, with the one or more melanin-based energy storage materials reversibly binding the cations while the biocompatible energy storage device is in an inactive state, and the one or more melanin-based energy storage materials releasing the cations to provide energy while the energy storage device is in an active state.. .
Carnegie Mellon University


02/18/16
20160048793 

Microjob rating and payment system


A system and method in which a rating or feedback based system is used on a web or mobile based application for a microjob, also known as a small task, gig, freelance job or microwork. The rating or feedback based system is used to determine either qualification for a microjob, payment for a microjob, or both.

02/18/16
20160046688 

Peptide analogs of alpha-melanocyte stimulating hormone


Provided herein are stable peptide analogs of the native alpha-melanocyte stimulating hormone (α-msh) having selectivity for the melanocortin 1 receptor (mc1r). Also provided herein are pharmaceutical preparations of the α-msh peptide analogs, as well as methods of using these analogs in the treatment of medical and veterinary conditions involving mc1r..
Genzyme Corporation


02/18/16
20160045468 

Novel therapeutic target for the treatment of cancers and related therapies and methods


Disclosed herein are compositions and methods for treating or preventing certain cancers in a subject. In certain embodiments such compositions and methods generally relate to the use of g-coupled protein receptor 40 (gpr40) agonists to inhibit the growth or induce apoptosis of certain cancer cells.
Children's Medical Center Corporation


02/11/16
20160043898 

Linked list scripting engine


A system and a method are creating a linked list scripts for a networking device. The system receives a set of nodes defining script functionality and generates a script by coupling the nodes in a nodal structure based on desired order of execution, wherein a leaf node is an standalone node with no child node, and wherein a nugget node includes one or more child nodes, each child node being a nugget or leaf node.
Opera Software Ireland Limited


02/11/16
20160043074 

Junctionless nanowire transistors for 3d monolithic integration of cmos inverters


The invention provides a three dimensional (3d) semi-conductor device comprising a first junctionless transistor doped with dopants of the same polarity; a second junctionless transistor doped with dopants of the same polarity; and the second junctionless transistor and the first junctionless transistor comprise an opposite dopant polarity are stacked in a vertical arrangement, where the first and second junctionless transistors are separated by an insulating layer. The invention makes use of the fact that the transistors are uniformly doped with the same polarity to provide a junctionless transistor.
University College Cork - National University Of Ireland, Cork


02/11/16
20160041652 

Interface apparatus and methods


Input devices are provided. In accordance with an example embodiment, an input device includes an interface layer that flexes in response to pressure, a plurality of sense electrodes, a dielectric between the sense electrodes and the interface layer, and interconnecting circuitry.
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160041185 

Methods of detecting complement fixing and non-complement fixing antibodies and systems for practicing the same


Provided are methods for simultaneously determining the presence or absence of complement-fixing antibody (cfab) and non-complement-fixing antibody (non-cfab) in a biological sample in a single reaction. The methods include mixing a cellular sample from a donor, a biological sample from a recipient, isolated human complement component c1q (c1q), and a labeled c1q binding agent (cba), under conditions sufficient for recipient cfab and non-cfab, if present, to bind to donor cell surface antigen (ag) to form antibody-ag (ab-ag-c1q-cba) complexes.
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160040360 

Processes for pretreating and purifying a cellulosic material


A process for treating a cellulosic material comprising pretreating the cellulosic material and then extracting the cellulosic material with an extractant to selectively extract hemicellulose therefrom and separating the extracted hemicellulose to form a cellulosic product comprising less hemicellulose than the cellulosic material. The extractant comprises a cellulose solvent and a co-solvent.
Celanese Acetate Llc


02/11/16
20160040306 

Electrochemical process and system for producing glucose


An electrochemical process and system for producing glucose and glucose precursors are described. The process and system allow for the production of glucose from carbon dioxide and water, requiring only melanin, or a precursor, derivative, analog, or variant of melanin, and electromagnetic energy, such as visible or invisible light energy..

02/11/16
20160040269 

Refill for a ball-point pen and use thereof


The invention relates to a refill for a ball-point pen, comprising an ink cartridge and a ball, said ball being arranged in a writing tip provided at the front end of the ink cartridge, wherein at least the writing tip of the ink cartridge consists of a copper-zinc alloy of the following composition (wt. %): 28.0 to 36.0% zn, 0.5 to 1.5% si, 1.5 to 2.5% mn, 0.2 to 1.0% ni, 0.5 to 1.5% al, 0.1 to 1.0% fe, optionally also up to a maximum of 0.1% pb, optionally also up to a maximum of 0.2% sn, optionally also up to a maximum of 0.1% p, optionally also up to a maximum of 0.08% s, the rest being cu and inevitable impurities, with mixed silicides containing iron, nickel and manganese being embedded in the matrix..
Wieland-werke Ag


02/11/16
20160040134 

Virus like particle comprising modified envelope protein e3


A virus like particle comprising a viral structural protein which comprises modified envelope protein e3. The viral structural protein may be that derived from or alphavirus or flavivirus.
Vlp Therapeutics, Llc


02/11/16
20160039903 

High affinity pd-1 agents and methods of use


High affinity pd-1 mimic polypeptides are provided, which (i) comprise at least one amino acid change relative to a wild-type pd-1 protein; and (ii) have an increased affinity for pd-l1 relative to the wild-type protein. Compositions and methods are provided for modulating the activity of immune cells in a mammal by administering a therapeutic dose of a pharmaceutical composition comprising a high affinity pd-1 mimic polypeptide, which blocks the physiological binding interaction between pd-1 and its ligand pd-l1 and/or pd-l2..
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160039896 

Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha v beta 3 integrin


Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization..
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160039895 

Polypeptides targeting vascular endothelial growth factor receptor-2 and alpha v beta 3 integrin


Polypeptides comprising variant vascular endothelial growth factor sequences are provided. The polypeptides are useful in cancer imaging, cancer diagnosis, monitoring and treatment as well as treatment of diseases characterized by excessive neovascularization..
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160039845 

Bis-b-carboline compound and preparation method, pharmaceutical composition and use thereof


Disclosed in the present invention are a bis-β-carboline compound and a preparation method, a pharmaceutical composition and the use thereof. In particular, the bis-β-carboline compound and a pharmaceutical salt thereof are described as general formula i, and the bis-β-carboline compound is prepared through the condensation of β-carboline intermediate and dihaloalkane.
Xinjiang Huashidan Phar Maceutical Research Co., Ltd


02/11/16
20160039808 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


02/11/16
20160039792 

Activity-based probe compounds, compositions, and methods of use


Activity-based probe compounds for use in labeling a cysteine protease are provided. The compounds are targeted to the protease through a specific targeting element.
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160038764 

Optogenetic control of behavioral state


The present disclosure provides methods of modulating a feature of a behavioral state. The methods involve inhibiting or activating the activity of a bed nucleus of stria terminalis (bnst) neuron, a bnst subnucleus, or a neuronal output to or from a bnst neuron.
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160038578 

Fully human antibodies to high molecular weight-melanoma associated antigen and uses thereof


Disclosed herein are isolated human monoclonal antibodies, and functional fragments thereof, that specifically bind hmw-maa. Nucleic acids encoding these antibodies, expression vectors including these nucleic acid molecules, and isolated host cells that express the nucleic acid molecules are also disclosed.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


02/11/16
20160038514 

Adjunctive therapy with 25-hydroxyvitamin d and articles therefor


Methods, compositions, and kits for adjunctive therapy using 25-hydroxyvitamin d are disclosed. The 25-hydroxyvitamin d may be administered with an agent that increases the risk of hypocalcemia, such as cinacalcet or a salt thereof, and/or an anticancer agent.
Opko Ireland Global Holdings, Ltd.


02/11/16
20160038508 

Pharmaceutical compositions comprising sorbitan esters


The present invention relates to a pharmaceutical composition comprising sorbitan esters of carboxylic acids that are useful for the delivery of anti-psychotic drugs.. .
Alkermes Pharma Ireland Limited


02/11/16
20160038444 

Modulaton of cellular dna repair activity to intercept malignancy


Disclosed herein are methods for identifying compounds that enhance base excision repair, as well as compounds identified thereby and methods of using such compounds in the interception of malignancy, i.e. The prevention of progression of a disease from a state of susceptibility to active disease.
The Board Of Trustees Of The Leland Stanford Junior University


02/11/16
20160038174 

A device suitable for removing matter from inside the lumen and the wall of a body lumen


A device suitable for use in a body lumen and comprises an elongated control member having a distal and a proximal end, and a radially expansible member disposed at or near the distal end and adapted for collection and/or shearing of matter (i.e. Thrombus) from a wall of the body lumen (i.e.
National University Of Ireland Galway




Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph

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