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Elan patents



      

This page is updated frequently with new Elan-related patent applications.




Date/App# patent app List of recent Elan-related patents
07/21/16
20160210592 
 Systems and methods for crowdsourcing technology projects patent thumbnailnew patent Systems and methods for crowdsourcing technology projects
The technology introduced here enables a customer to readily view, and securely connect with, project managers and freelancers who complete projects on behalf of the customer. The customer initially posts a project specification through a crowdsourcing platform.
Crowdplat


07/21/16
20160207990 
 Antibodies to endoplasmin and their use patent thumbnailnew patent Antibodies to endoplasmin and their use
Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human.
University Of Pittsburgh - Of The Commonwealth Sys Tem Of Higher Education


07/21/16
20160207912 
 Heteroaryl amides as inhibitors of protein aggregation patent thumbnailnew patent Heteroaryl amides as inhibitors of protein aggregation
The present invention relates to certain heteroaryl amide compounds, pharmaceutical compositions containing them, and methods of using them, including methods for preventing, reversing, slowing, or inhibiting protein aggregation, and methods of treating diseases that are associated with protein aggregation, including neurodegenerative diseases such as parkinson's disease, alzheimer's disease, lewy body disease, parkinson's disease with dementia, fronto-temporal dementia, huntington's disease, amyotrophic lateral sclerosis, and multiple system atrophy, and cancer and melanoma.. .
Neuropore Therapies, Inc.


07/14/16
20160201896 
 Method of obtaining or maintaining optical transmittance into boiler liquid patent thumbnailMethod of obtaining or maintaining optical transmittance into boiler liquid
A clean-in-place method of maintaining optical transference through a light transference medium operably connected to a boiler system is disclosed. The method comprises inter alia contacting a liquid chemical agent to a wetted surface of a light transference medium.
Ecolab Usa Inc.


07/14/16
20160201032 
 Method of nociceptor differentiation of human embryonic stem cells and uses thereof patent thumbnailMethod of nociceptor differentiation of human embryonic stem cells and uses thereof
The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hesc), human induced pluripotent stem cells (hipsc), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hesc and/or hipsc to nociceptors (i.e.
Memorial Sloan Kettering Cancer Center


07/14/16
20160200775 
 Virus like particle comprising modified envelope protein e3 patent thumbnailVirus like particle comprising modified envelope protein e3
A virus like particle comprising a viral structural protein which comprises modified envelope protein e3. The viral structural protein may be that derived from or alphavirus or flavivirus.
Vlp Therapeutics, Llc


07/14/16
20160199381 
 Inhibition of thymine dna glycosylase in the treatment of cancer patent thumbnailInhibition of thymine dna glycosylase in the treatment of cancer
The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine dna glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine dna glycosylase in cancer cells.
Institut De Génétique Et De Biologie Moléculaire Et Cellulaire


07/07/16
20160194323 
 Histone demethylase inhibitors patent thumbnailHistone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrido[3,4-d]pyrimidin-4-one derivative compounds and pharmaceutical compositions comprising said compounds.
Celgene Quanticel Research, Inc.


07/07/16
20160194315 
 Histone demethylase inhibitors patent thumbnailHistone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted pyrrolopyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


07/07/16
20160194306 
 Histone demethylase inhibitors patent thumbnailHistone demethylase inhibitors
The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Celgene Quanticel Research, Inc.


07/07/16
20160194292 

Triazolone compounds and uses thereof


The invention disclosed herein is directed to compounds of formula (1a) and (1b) and pharmaceutically acceptable salts thereof, which are useful in the treatment of prostate, breast, colon, pancreatic, human chronic lymphocyticδ leukemia, melanoma and other cancers. The invention also comprises pharmaceutical compositions comprising a therapeutically effective amount of compound of formula (1a) or (1b), or a pharmaceutically acceptable salt thereof.
Inception 2, Inc.


07/07/16
20160193159 

Liposomal curcumin for treatment of cancer


The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system.
Board Of Regents, The University Of Texas System


07/07/16
20160193126 

Diarylalkanes as potent inhibitors of binuclear enzymes


The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction.
Unigen, Inc.


06/30/16
20160185873 

Monoclonal antibodies for treatment of cancer


The present invention provides antibodies useful as therapeutics for treating and/or preventing diseases associated with cells expressing gt468, including tumor-related diseases such as breast cancer, lung cancer, gastric cancer, ovarian cancer, hepatocellular cancer, colon cancer, pancreatic cancer, esophageal cancer, head & neck cancer, kidney cancer, in particular renal cell carcinoma, prostate cancer, liver cancer, melanoma, sarcoma, myeloma, neuroblastoma, placental choriocarcinoma, cervical cancer, and thyroid cancer, and the metastatic forms thereof. In one embodiment, the tumor disease is metastatic cancer in the lung..

06/30/16
20160185716 

Selective histone deactylase 6 inhibitors


Disclosed are selective histone deactylase inhibitors (hdaci) that having formula i. Specifically, the disclosed subject matter relates to compounds having activity as selective hdac6 inhibitors, methods of making and using the compounds, and compositions comprising the compounds.

06/30/16
20160185703 

Compounds from antrodia camphorata, preparing the same and use thereof


The invention relates to bioactive compounds purified from mycelium of antrodia camphorata and the manufacturing method thereof. A method for treatment of cancers by administrating an effective amount of the said compounds selected from the group consisting of ac006, ac007, ac009, ac011, ac012, ac007-h1, ac009-h1, and ac012-h1 wherein the cancers is liver cancer, brain cancer, prostate cancer, breast cancer, colorectal cancer, or melanoma..

06/30/16
20160184381 

Herbal combinations for treatment of a skin condition


A method and medicine for treating melanoma, bcc (basal cell carcinoma) or psoriasis or other inflammatory skin disease, or a combination thereof, comprising applying or injecting to an infected skin area of a patient diagnosed with melanoma, bcc (basal cell carcinoma) or psoriasis or other inflammatory skin disease, or a combination thereof, a treatment regimen that includes periodic doses of a molecular combination of emodin and digoxin and/or an herbal combination of da huang and sheng di huang.. .

06/23/16
20160180282 

Systems and methods for crowdfunding and crowdsourcing a project


A system and method for crowdfunding and crowdsourcing a project that receives, via communication circuitry, a project from a user, determines, using processing circuitry, whether the project adheres to a predetermined criteria, provides the project to a crowdsourcing community and a crowdfunding community, receives bids from one or more freelancers to implement one or more parts of the project, receives contributions from one or more contributors, selects at least one freelancer based on a predefined rule, determines a total amount of contributions, determines a total amount of funds needed, determines whether the total amount of contributions is at least equal to the total amount of funds needed, assigns the one or more parts of the project to the selected at least one freelancer, transmits an alert to at least on device associated with the selected at least one freelancer, and submits payments to the selected at least one freelancer.. .

06/23/16
20160177232 

Method of automatic dishwashing


A method of cleaning a dishwashing load comprising dishware and tableware having bleachable stains in the presence of iron in a dishwasher, the method comprising the step of contacting the ware with a detergent composition comprising an iron chelant wherein the detergent composition is free or substantially free of bleach and preferably has a ph as measured in 1% weight aqueous solution at 25° c. Of from about 5 to about 7.5.

06/23/16
20160177229 

Detergent composition


A substantially builder-free low-ph automatic dishwashing detergent composition comprising a buffer, an enzyme and an iron chelant and wherein the composition has a ph as measured in 1% weight aqueous solution at 25° c. Of from about 5 to about 7.5..

06/23/16
20160176925 

Melanocortin receptor ligands modified with hydantoin


The present invention relates to peptide ligands of the melanocortin receptors, in particular the melancortin-4 receptor, and as such, are useful in the treatment of disorders responsive to the activation of this receptor, such as obesity, diabetes mellitus and sexual dysfunction.. .

06/23/16
20160175391 

Drug containing recombinant mistletoe lectins for treating malignant melanoma


The invention relates to a drug and/or pharmaceutical composition for treating metastatic tumors, in particular of malignant melanoma, above all of stage iv malignant melanoma, and to the use of said drug, in particular the use of said drug in select patient populations.. .

06/23/16
20160175384 

Melanotropin ligands for skin care


A melanocortin 1 receptor (mc1r) peptide ligand-elastic vesicle complex. The mc1r peptide ligand is modified by coupling the mc1r ligand to a functionality or linker, such as a click functionality, for conjugation to a surface or agent.

06/23/16
20160175210 

Method of inhibiting copper deposition on hair


A method of inhibiting copper deposition on hair and facilitating the removal of copper deposited on hair including applying to the hair a bleaching or oxidative dyeing composition comprising a chelant, rinsing the bleaching or oxidative dyeing composition, applying to the hair a rinse-off conditioner composition comprising histidine, rinsing the rinse-off conditioner composition from the hair, applying to the hair a shampoo composition having ethylenediamine-n,n′-disuccinic acid and/or histidine, rinsing the shampoo composition from the hair, applying to the hair a rinse-off conditioner composition comprising histidine, and rinsing the conditioner composition from the hair.. .

06/23/16
20160174603 

Electronic vapor liquid composition and use


An e-liquid for use in electronic cigarettes which utilizes a vaporizing base (either propylene glycol, vegetable glycerin, or mixture of the two) mixed with an herbal powder extract generally at a 0.001 g-2.0 g per 1 ml ratio. The herbal extract can be any of the following: kanna (sceletium tortuosum), blue lotus (nymphaea caerulea), salvia (salvia divinorum), salvia eivinorm, kratom (mitragyna speciosa), celandine poppy (stylophorum diphyllum), mugwort (artemisia), coltsfoot leaf (tussilago farfara), california poppy (eschscholzia californica), sinicuichi (heimia salicifolia), st.

06/23/16
20160174595 

Method for reduction of flying insects in livestock feeds and feed supplements


Methods for reducing flying insects from animal feeds or animal feed supplements involve, in a location accessible to flying insects, providing a livestock animal with an animal feed or a liquid supplement and a palatant or a molasses replacement in an amount effective to reduce flying insects from occupying an area on and around the animal feed or the liquid supplement. The palatant or the hydrolyzed whey within the palatant may account for at least about 2 percent of the animal feed or liquid supplement by weight.

06/16/16
20160168227 

Composition and vaccine for treating lung cancer


The present invention relates to a composition comprising at least one mrna encoding a combination of antigens capable of eliciting an (adaptive) immune response in a mammal, wherein the antigens are selected from the group consisting of 5t4 (trophoblast glycoprotein, tpbg), survivin (baculoviral tap repeat-containing protein 5; birc5), ny-eso-1 (new york esophageal squamous cell carcinoma 1, ctag1b), mage-c1 (melanoma antigen family c1), mage-c2 (melanoma antigen family c2), and muc1 (mucin 1). The invention furthermore relates to a vaccine comprising at least one mrna encoding such a combination of antigens, and to the use of said composition (for the preparation of a vaccine) and/or of the vaccine for eliciting an (adaptive) immune response for the treatment of lung cancer, preferably of non-small cell lung cancer (nsclc), and diseases or disorders related thereto.
Curevac Ag


06/16/16
20160168121 

Quinoline derivative


A compound represented by general formula (i) has a strong axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.. .
Ono Pharmaceutical Co., Ltd.


06/16/16
20160166194 

System and optical detection of skin disease


An optical system for the detection of skin disease, such as melanoma, acquires images of a lesion on a subject's skin at different wavelengths and utilizes a sweeping arm rotating about the lesion in a clock-like sweep to produce diagnostically relevant metrics and classifiers from the image data so as to enhance detection of the skin disease.. .
The Rockefeller University


06/16/16
20160165891 

Synergistic herbicidal composition containing penoxsulam, triclopyr and bispyribac


Methods for controlling weeds using synergistic compositions containing penoxsulam, triclopyr, and bispyribac, especially rice, sugarcane, cereal and grain crops, pastures, rangelands, industrial vegetation management (ivm), aquatics and turf, as well as protecting crops from herbicidal injury caused by any of the individual components. These methods provide improved post-emergence herbicidal weed control and reduce herbicidal injury by concomitant application of the mixture..
Dow Agrosciences Llc


06/09/16
20160162731 

Method and system for optimizing accuracy-specificity trade-offs in large scale visual recognition


As visual recognition scales up to ever larger numbers of categories, maintaining high accuracy is increasingly difficult. Embodiment of the present invention include methods for optimizing accuracy-specificity trade-offs in large scale recognition where object categories form a semantic hierarchy consisting of many levels of abstraction..
The Board Of Trustees Of The Leland Stanford Junior University


06/09/16
20160161438 

Sensing platform for quantum transduction of chemical information


A system for determining chemistry of a molecule in a high background interfering liquid environment by application of an electronic signal at a biased metal-electrolyte interface is disclosed. One or more of a resonant exchange of energy between one or more electrons exchanged by the metal and the electrolyte and vibrating bonds of a molecular analyte, for example, may be sensed by measuring small signal conductivity of an electrochemical interface..
The Board Of Trustees Of The Leland Stanford Junior University


06/09/16
20160160208 

Capillary barriers for staged loading of microfluidic devices


Various aspects of the present disclosure are directed toward methods and apparatuses for interacting a first liquid and a second liquid in one or more fluidic channels of a capillary structure. The methods and apparatuses can include providing at least one capillary barrier that positions a meniscus of the first liquid at a fluid-interface region using capillary forces within the capillary structure.
The Board Of Trustees Of The Leland Stanford Junior University


06/09/16
20160159832 

Silylalkyloxyaryl compounds and methods for treating cancer


Silylalkyloxyaryl compounds useful as anti-cancer agents. The compounds and pharmaceutical compositions containing them are particularly useful for the treatment of melanoma, colon, neuroblastoma, bladder, breast, lung, pancreatic, melanoma, sarcoma, lymphoma or gastric cancer..
The Regents Of The University Of Colorado, A Body Corporate


06/09/16
20160159803 

Pteridines useful as hcv inhibitors and methods for the preparation thereof


The present invention relates to the use of pteridines as inhibitors of hcv replication as well as their use in pharmaceutical compositions aimed to treat or combat hcv infections. In addition, the present invention relates to compounds per se and their use as medicines.
Janssen Sciencies Ireland Uc


06/09/16
20160159721 

Processes for producing an acetic acid product having low butyl acetate content


A process for producing an acetic acid product having low butyl acetate content via a carbonylation reaction. The carbonylation reaction is carried out at a temperature from 100 to 300° c., a hydrogen partial pressure from 0.3 to 2 atm, and a metal catalyst concentration from 100 to 3000 wppm, based on the weight of the reaction medium.
Celanese International Corporation


06/02/16
20160153968 

Method of screening for candidate compounds for regulating melanogenesis or pigmentation


A method to identify target genes or proteins for regulating melanogenesis or pigmentation and to screen for compounds for manipulation of melanogenesis or pigmentation, the method of screening for candidate compounds for regulating melanogenesis or pigmentation, includes bringing test compounds into contact with cells capable of expressing mortalin and/or hsp60 in vitro, and selecting, from among the test compounds, a compound that changes the expression level of mortalin and/or hsp60.. .
National Institute Of Advanced Industrial Science And Technology


06/02/16
20160152986 

Methods and materials for treating cancer


This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an scd1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccrcc)) or to increase the efficacy of a renal cell carcinoma treatment are provided.
Mayo Foundation For Medical Education And Research


05/26/16
20160146600 

Novel technique of displacement and rotation measurement


A simple and reliable novel method providing the ability to measure the spatial relative displacement and rotation of objects as well as the measurement of the different degrees of freedom of each object (i.e. Rotations and translations) relative to an inertial frame.

05/26/16
20160145206 

N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use


The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (copd); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as behçet's disease.
Pimco 2664 Limited


05/26/16
20160143255 

Animal models of ataxia-telangiectasia (a-t)


The present invention provides transgenic, large non-human animal models of ataxia-telangiectasia, as well as methods of using such animal models in the identification and characterization of therapies for ataxia-telangiectasia.. .
Exemplar Genetics, Llc


05/19/16
20160143195 

Immobilized melanin and its chemical derivatives for the harvesting or shielding of high energy electromagnetic radiation


A method and apparatus for a photocatalytic and electrolytic electromagnetic shielding and responsive polymer includes in various aspects one or more electromagnetic shielding and responsive polymers, a method for forming a electromagnetic shielding and responsive polymer, an electrolytic electromagnetic energy dispersion cell, and a reaction method, as well as applications.. .

05/19/16
20160139132 

Method of diagnosis or prognosis of a neoplasm comprising determining the level of expression of a protein in stromal cells adjacent to the neoplasm


The invention provides diagnostic and therapeutic methods for neoplastic disease patients with neoplasms of, for example, the breast, skin, kidney, lung, pancreas, rectum and colon, prostate, bladder, epithelial, non-epithelial, lymphomas, sarcomas, melanomas, and the like, wherein the method comprises determining the level of expression of cavcolin-1, cavcolin-2, vimentin, calponon2, tropomyosin, gelsolin, prolyl 4-hydroxylase alpha, ef-i-delta, or m2-isoform of pyruvate kinase in stromal cells adjacent to the neoplasm.. .
Thomas Jefferson University


05/19/16
20160136132 

A pharmaceutical combination for the treatment of melanoma


The present invention relates to a pharmaceutical combination comprising a cyclin dependent kinase (cdk) inhibitor represented by a compound of formula i (as described herein) or a pharmaceutically acceptable salt thereof; and at least one anticancer agent selected from a braf inhibitor or a mek inhibitor, for use in the treatment of melanoma. The present invention also relates to a method for the treatment of melanoma comprising administering to a subject in need thereof, a therapeutically effective amount of a cdk inhibitor and a therapeutically effective amount of at least one anticancer agent selected from a braf inhibitor or a mek inhibitor..
Piramal Enterprises Limited


05/19/16
20160136079 

A3 adenosine receptor ligands for modulation of pigmentation


The present invention relates to compositions and methods for modulating melanin production, secretion and/or accumulation in human skin cells. In particular, the present invention relates to the use of a3 adenosine receptor antagonists in compositions and methods for the treatment and amelioration of hyper-pigmentation conditions and for the lightening of skin, and to the use of a3 adenosine receptor agonists in compositions and methods for the treatment and amelioration of hypo-pigmentation conditions and for the tanning of skin..
Oradin Pharmaceutical Ltd.


05/19/16
20160136070 

Methods and compositions for enhancing skin pigmentation


Described herein are methods and compositions useful for enhancing pigmentation, such as skin, eye and/or hair pigmentation comprising administering e.g., an nnt inhibitor or an agent that modifies redox status in a melanocyte.. .
The General Hospital Corporation


05/19/16
20160135889 

Method for depilation by photothermolysis with melanin


Improved melanin-enhanced photothermolysis hair removal method, which includes the application of liposome-encapsulated melanin solutions as a chromophore onto the skin and the use of mechanical devices having microneedles to favor absorption thereof by the hair follicles.. .
Dermopartners,s.l.


05/12/16
20160130625 

Methods for producing melanin and inorganic fertilizer from fermentation leachates


Melanin or inorganic fertilizers are produced from fermentation leachates or from low-cost nutrient-rich solutions. The method for producing the melanin or inorganic fertilizer comprises repetitive trophic cycling in the controlled conditions of primary and secondary bioreactors.
River Road Research, Inc.


05/12/16
20160130534 

Pourable detergent composition comprising suspended particles


The present invention relates to a pourable thixotropic detergent composition comprising a continuous phase and at least 0.3 wt. % of suspended particles comprising water-soluble surfactant, said continuous phase containing at least 10 wt.
Conopco, Inc., D/b/a Unilever


05/12/16
20160130532 

Hygroscopic detergent formulation comprising water, aminocarboxylate chelant and moisture-sensitive ingredients


The present invention relates to a detergent formulation comprising water, one or more moisture-sensitive detergent ingredients and an aminocarboxylate chelant comprising at least three carboxylate residues; wherein the combination of aminocarboxylate chelant and water represents at least 20% by weight of the detergent formulation; wherein the weight ratio of aminocarboxylate chelant to water lies within the range of 5:6 to 5:1; and wherein the detergent formulation has a ph in the range of 7.2 to 12. The detergent composition offers the advantage that adverse effects of water uptake during storage are minimized.
Conopco, Inc., D/b/a Unilever


05/12/16
20160129077 

Use of recombinant ganoderma immunoregulatory protein (rlz-8) in preparation of drug for treating melanoma


A use of recombinant ganoderma immunoregulatory protein (rlz-8) in a preparation of a drug for treating melanoma is disclosed. By establishing experimental animal models of orthotopic tumors and metastatic tumors, an anti-tumor effect of the rlz-8 is researched, which indicates that the rlz-8 significantly inhibits a growth of the orthotopic tumors of the melanoma and a formation of metastases of the melanoma..

05/12/16
20160129009 

High purity diaminophenothiazinium compounds including methylthioninium chloride (mtc)


This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7 diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiaziniumcompounds”) including methythioninium chloride (mtc) (also known as methylene blue). In one embodiment, the method comprises the steps of, in order: nitrosylation (nos); nitrosyl reduction (nr); thiosulfonic acid formation (tsaf); oxidative coupling (oc); cr(vi) reduction (cr); isolation and purification of zwitterionic intermediate (iapozi); ring closure (rc); chloride salt-formation (csf); one of: sulphide treatment (st); dimethyldithiocarbamate treatment (dt); carbonate treatment (ct); ethylenediaminetetraacetic acid treatment (edtat); organic extraction (oe); and recrystallisation (rx).
Wista Laboratories Ltd.


05/05/16
20160122323 

Inhibitors of cyclin-dependent kinase 7 (cdk7)


The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.


05/05/16
20160122314 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic diseases. Provided herein are substituted imidazole-pyridine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals, Inc.


05/05/16
20160120914 

Treating a lymphoma with a whole, leech saliva extract


Methods are also provided for isolating and using a whole-saliva leech extract in the treatment of a melanoma. The methods can include feeding a phagostimulatory agent to a leech; inducing a regurgitation in the leech, the inducing including placing the leech in an environment having a temperature of less than about 0° c.; and, collecting an unrefined, whole saliva in the regurgitation of the cooled leech.
Biopep Solutions, Inc.


04/28/16
20160115555 

Biomarkers for differentiating melanoma from benign nevus in the skin


Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (phactr1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (spp1), preferentially expressed antigen in melanoma (prame), growth differentiation factor 15 (gdf15), and chemokine c-x-c motif ligand 10 (cxcl10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of phactr1, or fragments thereof, either alone or in combination with the detection of spp1, prame, gdf15, and cxcl10, for the diagnosis or prognosis of melanoma..
Advanced Cell Diagnostics


04/28/16
20160115468 

Albumin-binding arginine deiminase for cancer targeting treatment and detection of arginine


The present invention provides a pharmaceutical composition containing albumin-binding arginine deiminase (aad) fusion protein for treating cancer or other arginine-dependent diseases. The aad fusion protein can be purified from both soluble and insoluble fractions of crude proteins, it binds to human serum albumin (hsa) or animal serum albumin and has its high activity with longer half life for efficient depletion of arginine in cancer cells.
Vision Global Holdings Ltd.


04/28/16
20160115131 

Histone demethylase inhibitors


The present invention relates generally to compositions and methods for treating cancer and neoplastic disease. Provided herein are substituted amidopyridine or amidopyridazine derivative compounds and pharmaceutical compositions comprising said compounds.
Quanticel Pharmaceuticals. Inc.




Elan topics: Folic Acid, Carbon Dioxide, Antibodies, Immune Response, High Energy, Inorganic Compounds, Electrolysis, Semiconductor Material, Semiconductor, Hydrogen Production From Water, Female Sexual Dysfunction, Dysfunction, Sexual Dysfunction, Mammography, Radiograph

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