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|| List of recent Efavirenz-related patents
The present invention relates to a combination therapy for treating an hiv infection or inhibiting integrase comprising (s)-6-(3-chloro-2-fluorobenzyl)-1-(1-hydroxymethyl-2-methylpropyl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (“compound a”) or a pharmaceutically acceptable solvate or salt thereof in combination with at least one other anti-hiv agent. In some embodiments of the present invention, the other anti-hiv agents are chosen from reverse transcriptase inhibitors and protease inhibitors.
|Compositions of efavirenz|
The present inventions relates to a solid composition and an aqueous dispersion comprising nanoparticles of the anti-retroviral drug efavirenz. The solid composition and aqueous dispersion additionally comprise a mixture of a hydrophilic polymer and a surfactant.
|Highly loaded amorphous efavirenz composition and process for preparing the same|
A stable and high loading ternary solid dispersion composition comprising (a) about 50% wt. To about 90% wt.
|Method and composition for pharmaceutical product|
This invention is directed to a composition comprising dry granulated tenofovir df and emtricitabine, and a method for making same. Dry granulation was unexpectedly found to be important in preparing a tenofovir df containing composition suitable for inclusion in a combination dosage form containing emtricitabine, efavirenz and tenofovir df..
|Unitary pharmaceutical dosage form|
In accordance with this invention a novel pharmaceutical product containing efavirenz, emtricitabine and tenofovir df are provided as a multicomponent unitary oral dosage form, component 1 comprising tenofovir df (and, optionally, emtricitabine) and component 2 comprising efavirenz, wherein components 1 and 2 are in a stabilizing configuration. In preferred embodiments component 1 is made by dry granulation..
A pharmaceutical composition comprising efavirenz wherein the efavirenz is in the form of nanoparticles is disclosed.. .
|Process for the preparation of efavirenz|
As a free base or a salt thereof, with diphosgene (tcmcf, trichloromethylchloroformate) cl3co—cocl in an organic solvent or in a biphasic medium comprised of an organic solvent and water, preferably but not mandatorily in the presence of a weak base in an amount sufficient to neutralize the reaction mixture or in an up to 30% molar excess of such amount.. .
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Efavirenz topics: Human Immunodeficiency Virus, Reverse Transcriptase, Lamivudine, Reverse Transcriptase Inhibitor, Chloroform, Atazanavir, Protease Inhibitor, Wet Milling, Reverse Transcriptase Inhibitors, Nevirapine, Hiv Reverse Transcriptase, Delavirdine
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