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Dna Sequence

Dna Sequence-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Minimizing errors using uracil-dna-n-glycosylase
Abbott Molecular Inc.
January 18, 2018 - N°20180016641

Provided herein is technology relating to enzymatic modification of nucleic acids and particularly, but not exclusively, to methods and compositions relating to using uracil-dna-n-glycosylase for minimizing or eliminating errors in a dna sequence due to deamination of cytosine residues.
NEW Methods for characterizing dna sequence composition in a genome
Pioneer Hi-bred International, Inc.
January 18, 2018 - N°20180016626

Methods for the high-throughput analysis of transgenic events are herein disclosed. The methods use libraries of sheared genomic dna ligated to specialized adapters and pooled for sequence analysis and comparison to known genomic and insert sequence. The method finds use in detecting characterizing insertion site, transgene integrity, and transgene copy number.
NEW Methods for modulating genome editing
The Regents Of The University Of California
January 18, 2018 - N°20180016601

Provided herein are methods and kits for modulating genome editing of target dna. The invention includes using small molecules that enhance or repress homology-directed repair (hdr) and/or nonhomologous end joining (nhej) repair of double-strand breaks in a target dna sequence. Also provided herein are methods for preventing or treating a genetic disease in a subject by enhancing precise genome ...
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Barcoding sequences for identification of gene expression
Microsoft Technology Licensing, Llc
January 04, 2018 - N°20180002748

Gene expression can be identified by analyzing a dna sequence. The dna sequence can include a barcode sequence that corresponds to a particular gene. The barcode sequence can be produced during the expression of a gene by first adding a homologous directed repair (hdr) template including the barcode sequence into the dna sequence of the gene and then splicing the ...
Storage through iterative dna editing
Microsoft Technology Licensing, Llc
January 04, 2018 - N°20180002725

Information is stored in existing dna through an iterative process of creating a break in dsdna and adding new dna by repairing the break with a homologous repair template. The order and sequence of dna sequences added to the breaks in the dsdna can encode binary data. By using a context-dependent encoding scheme, three unique homologous repair templates can encode ...
Maize event dp-004114-3 and methods for detection thereof
E. I. Du Pont De Nemours And Company
December 28, 2017 - N°20170369953

The invention provides dna compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize dp-004114-3 event based on the dna sequence of the recombinant construct inserted into the maize genome and the dna sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
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Site-specific dna recombination
Nanyang Technological University
December 21, 2017 - N°20170362606

The present invention provides a method of stably integrating a dna sequence of interest into a target genomic dna sequence of a host cell, wherein the target genomic dna sequence comprises a nucleotide sequence that is at least 80% homologous to the sequence as set forth in seq id no:1, as well as a kit for use in said method. Also ...
Non-viral ipscs inducing composition and kits
Guangzhou Biocare Biotechnology Co., Ltd
December 14, 2017 - N°20170356005

The present invention relates to a non-viral ipscs induction composition and the kits thereof. Specifically, it comprises a recombinant plasmid, and the recombinant plasmid is obtained by constructing the dna sequences expressing the reprogramming factors pou5f1, sox2, glis1, klf4, mycl and hsa-mir-302s into an episomal vector; the dna sequence of hsa-mir-302s comprises one or more sequences selected ...
Non-viral ipscs inducing method, compositions, kits and ipscs
Guangzhou Biocare Biotechnology Co., Ltd
December 14, 2017 - N°20170355965

The present invention relates to a non-viral ipscs induction method as well as the compositions, kits and ipscs obtained therefrom. More specifically, the induction method comprises the following steps: 1) constructing a recombinant plasmid by introducing the dna sequences expressing the reprogramming factors pou5f1, sox2, glis1, klf4, mycl and hsa-mir-302s into an episomal vector; 2) obtaining ipscs by introducing the ...
A dna-methylation test for prostate cancer
University College Dublin National University Of Ireland, Dublin
December 07, 2017 - N°20170349952

A method of determining the risk of metastatic prostate cancer in an individual diagnosed with prostate cancer, the method comprising a step of assaying a biological sample obtained from the individual for the presence of at last one methylated regulatory dna sequence selected from group comprising: sequence id no's 1 to 16, or variants thereof, and correlating the presence or absence of ...
Lipid bilayer-integrated spp1 connector protein nanopore and spp1 connector protein variants for use as lipid ...
University Of Kentucky Research Foundation
November 30, 2017 - N°20170343530

A conductive channel-containing membrane includes a membrane layer, and a spp1 connector polypeptide variant that is incorporated into the membrane layer to form an aperture through which conductance can occur when an electrical potential is applied across the membrane. A method of sensing a molecule, such as a polypeptide or nucleic acid molecule, makes use of the conductive channel-containing membrane. ...
Subtilase variants and polynucleotides encoding same
Novozymes A/s
November 23, 2017 - N°20170335307

The present invention relates to subtilase variants suitable for use in, e. G., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated dna sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention.
Rationally-designed meganucleases with altered sequence specificity and dna-binding affinity
Duke University
November 23, 2017 - N°20170335299

Rationally-designed laglidadg meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired dna sequence inserted into a limited number of loci within the genome, as well as methods of gene therapy, for treatment of pathogenic infections, and for in vitro applications in diagnostics ...
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Corn event pv-zmgt32(nk603) and compositions and methods for detection thereof
Monsanto Technology Llc
November 16, 2017 - N°20170327838

The present invention provides a dna construct that confers tolerance to transgenic corn plant. Also provided are assays for detecting the presence of the pv-zmgt32(nk603) corn event based on the dna sequence of the recombinant construct inserted into the corn genome and of genomic sequences flanking the insertion site.
Oligonucleotides for genomic dna editing
Proqr Therapeutics Ii B.v.
November 16, 2017 - N°20170327821

A method for making a change in an endogenous chromosomal dna sequence of a mammalian cell, comprising steps of: (i) introducing into said cell an oligonucleotide having a sequence that is complementary to the chromosomal dna sequence and that includes the change; (ii) allowing sufficient time for the cell to incorporate the change into the endogenous chromosomal dna sequence through ...
Method for modifying genome sequence to introduce specific mutation to targeted dna sequence by base-removal ...
National University Corporation Kobe University
November 09, 2017 - N°20170321210

The present invention provides a method of modifying a targeted site of a double stranded dna, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded dna and dna glycosylase with sufficiently low reactivity with a dna having an unrelaxed double helix structure (unrelaxed ...
Plastid transformation of maize
November 02, 2017 - N°20170314032

A method is provided for transforming monocotyledonous plants to express dna sequences of interest from plant cell plastids. The method allows the transformation of monocot plant tissue with heterologous dna constructs. The invention also provides for monocot cells in which the plastids contain heterologous dna constructs.
Ca125 gene and its use for diagnostic and therapeutic interventions
October 26, 2017 - N°20170305980

The ca125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The ca125 molecule comprises three major domains: an extracellular amino terminal domain (domain 1); a large multiple repeat domain (domain 2); and a carboxy terminal domain (domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated ...
Targeted deletion of cellular dna sequences
October 19, 2017 - N°20170298385

Disclosed herein are methods and compositions for targeted deletion of double-stranded dna. The compositions include fusion proteins comprising a cleavage domain (or cleavage half-domain) and an engineered zinc finger domain, and polynucleotides encoding same. Methods for targeted deletion include introduction of such fusion proteins, or polynucleotides encoding same, into a cell such that two targeted cleavage events occur. Subsequent cellular ...
Stem cell gene targeting
October 19, 2017 - N°20170298384

The invention provides a method for generating a transgenic eukaryotic cell population having a modified human rosa26 locus, which method includes introducing a functional dna sequence into the human rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human rosa26 ...
Kit for cancer detection
Lihpao Life Science Corp.
October 12, 2017 - N°20170292164

The present invention provides a primer set and a kit containing same for analyzing a sequence of an mlh1 dna, an mlh1 mrna, and/or a cdna sequence derived from said mlh1 mrna of a subject to identify a v384 alteration of an mlh1 gene encoded protein.
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