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Dna Sequence patents

      

This page is updated frequently with new Dna Sequence-related patent applications.




 Method for using protein databases to identify microorganisms patent thumbnailMethod for using protein databases to identify microorganisms
A method for identifying microorganisms by maldi-tof mass spectrometry includes acquiring a maldi mass spectrum of a microorganism, detecting peaks in the acquired maldi spectrum, generating a peak list comprising mass and intensity from the detected peaks in the acquired maldi spectrum, acquiring a database of protein sequences deduced from dna sequences for microorganisms, generating a sub-database of ribosomal proteins from the protein sequences and their masses in the database, matching masses of the detected peaks in the acquired maldi spectrum to masses of the ribosomal proteins in the generated sub-database, scoring the matches obtained above for each represented microorganism, generating a peak list of accurate masses of matched ribosomal proteins, recalibrating the peak list comprising mass and intensity with the peak list of accurate masses of matched ribosomal proteins, identifying a microorganism with the highest score, and repeating until a desired improvement in the recalibrated peak list or a validated identification is achieved.. .
Virgin Instruments Corporation


 Gene encoding fhb1 resistance to fusarium head blight disease and uses thereof patent thumbnailGene encoding fhb1 resistance to fusarium head blight disease and uses thereof
A protein conferring resistance to fusarium head blight disease (fhb) is described, along with the dna sequence of the corresponding gene and mrna copy (cdna). The cdna of fhb1 gene can be used to produce genetically-modified plants having increased resistance to fhb, particularly in wheat, barley and other plants affected by the disease.
Regents Of The University Of Minnesota


 Diagnostic method patent thumbnailDiagnostic method
(d) comparing the level of the dna sequence from the individual to a normal standard, to detect, prognosticate or monitor cancer.. .

 Biological state machines patent thumbnailBiological state machines
Provided herein are recombinase-based frameworks for building state machines in vitro and in vivo by using chemically controlled dna excision and inversion operations to encode state in dna sequence.. .
Massachusetts Institute Of Technology


 Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair patent thumbnailMethods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair
Provided herein include methods and compositions for making targeted changes to a dna sequence. In various aspects and embodiments, methods and compositions for modifying a dna sequence in a cell (such as a plant, bacterial, yeast, fungal, algal, or mammalian cell) are provided.
Cibus Europe B.v.


 Modified coagulation factor viia with extended half-life patent thumbnailModified coagulation factor viia with extended half-life
The present invention relates to the fields of factor vii (fvii) and factor viia (fviia) albumin linked polypeptides. More specifically, the invention relates to cdna sequences coding for human factor vii and factor viia and derivatives genetically fused to a cdna coding for human serum albumin which may be linked by oligonucleotides which code for intervening peptidic linkers such encoded derivatives exhibiting improved stability and extended functional plasma half-life, recombinant expression vectors containing such cdna sequences, host cells transformed with such recombinant expression vectors, recombinant polypeptides and derivatives which do have biological activities of the unmodified wild type protein but having improved stability and prolonged shelf-life and processes for the manufacture of such recombinant proteins and their derivatives.
Csl Behring Gmbh


 Methods and compositions for genomic target enrichment and selective dna sequencing patent thumbnailMethods and compositions for genomic target enrichment and selective dna sequencing
It has been established that one or more large double stranded dna fragments (each 2,000 to 40,000 base pairs in size) can be captured and isolated from genomic dna fragments using sequence specific pna hybridization probes. Compositions and methods for enrichment of a multiplicity of long dna sequences selected from the genome of any eukaryote are provided.
Petaomics, Inc.


 Genomic sequence modification  specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same patent thumbnailGenomic sequence modification specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same
The present invention provides a method of modifying a targeted site of a double stranded dna, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded dna and a nucleic acid base converting enzyme are bonded, with the double stranded dna, to convert one or more nucleotides in the targeted site to other one or more nucleotides or delete one or more nucleotides, or insert one or more nucleotides into the targeted site, without cleaving at least one chain of the double stranded dna in the targeted site.. .
National University Corporation Kobe University


 Identification of somatic mutations versus germline variants for cell-free dna variant calling applications patent thumbnailIdentification of somatic mutations versus germline variants for cell-free dna variant calling applications
The present disclosure provides systems and methods to detect somatic or germline variants by providing a predetermined genomic dna (gdna) to an assay mixture, and capturing a sample of a subject's genetic information using a dna sequencer and detecting genetic variants from the genetic information. A mutation may then be classified as being from a germline source if gdna derived molecules have lengths inconsistent with those expected from cell-free dna (cfdna) derived molecules..
Guardant Health, Inc.


 Human antibody-producing cell patent thumbnailHuman antibody-producing cell
It is an object of the present invention to provide a chicken b cell that expresses a variety of human antibodies. The solution to the problem in the present invention is a chicken b cell, in which, in an antibody light chain gene locus thereof, all or a part of a dna sequence derived from a human antibody light chain variable region and a human antibody light chain constant region are inserted, or the antibody light chain gene locus is replaced with all or a part of a dna sequence derived from a human antibody light chain variable region and a human antibody light chain constant region, and in an antibody heavy chain gene locus thereof, all or a part of a dna sequence derived from a human antibody heavy chain variable region and a human antibody heavy chain constant region are inserted, or the antibody heavy chain gene locus is replaced with all or a part of a dna sequence derived from a human antibody heavy chain variable region and a human antibody heavy chain constant region, and in an antibody light chain pseudogene locus thereof, two or more dna sequences derived from human antibody light chain variable regions are inserted, or the antibody light chain pseudogene locus is replaced with two or more dna sequences derived from human antibody light chain variable regions, and/or in an antibody heavy chain pseudogene locus thereof, two or more dna sequences derived from human antibody heavy chain variable regions are inserted, or the antibody heavy chain pseudogene locus is replaced with two or more dna sequences derived from human antibody heavy chain variable regions..
Chiome Bioscience Inc.


Oncolytic adenovirus encoding a b7 protein or active fragment

The present disclosure provides a replication competent oncolytic adenovirus with selectivity for cancer cells, wherein the adenovirus comprises a transgene under the control of a promoter endogenous to the virus, wherein the transgene comprises a dna sequence encoding a b7 protein or an active fragment thereof, compositions comprising same, methods of generating the viruses, and use of the viruses and compositions in treatment, particularly in the treatment of cancer.. .
Psioxus Therapeutics Limited

Methods and systems for identifying crispr/cas off-target sites

Methods and systems for searching genomes for potential crispr off-target sites are provided. In preferred embodiments, the methods include identifying possible on- and off-target cleavage sites and/or ranking the potential off-target sites based on the number and location of mismatches, insertions, and/or deletions in the grna guide sequence relative to the genomic dna sequence at a putative target site in the genome.
Georgia Tech Research Corporation

Production of modified fatty acids in plants through rdna targeted integration of heterologous genes

The present invention relates to transgenic plants comprising a plurality of nucleic acids heterologous to said plant, each of said nucleic acid comprising a coding sequence operably linked to one or more regulatory elements for directing expression of said coding sequence in said plant, said nucleic acid being stably integrated at or adjacent to rdna sequences, or a seed, organ, tissue, part or cell thereof, or a descendant of said plant, seed, organ, tissue, part or cell; methods of producing the transgenic plants; and methods of producing oil using the transgenic plants.. .
Agrisoma Biosciences Inc.

Modular dna-binding domains and methods of use

The present invention refers to methods for selectively recognizing a base pair in a dna sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a dna sequence and, to dna which is modified so that it can be specifically recognized by a polypeptide and to uses of the polypeptide and dna in specific dna targeting as well as to methods of modulating expression of target genes in a cell.. .

Methods of using cyclooxygenase-prostacyclin synthase fusion gene

An effective amount of a composition comprising (i) a plasmid having a cyclooxygenase-prostacyclin synthase fusion gene, and (ii) a carrier fluid for use in treating an individual having a vascular disease or at risk of developing a vascular disease. A composition comprising a carrier fluid; and a dna sequence encoding for a triple catalytic enzyme, a cdna sequence encoding for a triple catalytic enzyme, a plasmid comprising a dna sequence encoding for a triple catalytic enzyme, a fusion gene encoding for a triple catalytic enzyme, a cyclooxygenase-prostacyclin synthase fusion gene, or combinations thereof, for use in treating an individual having a vascular disease or at risk of developing a vascular disease..
Texas Heart Institute

Characterization and directed evolution of a methyl binding domain protein for high-sensitivity dna methylation analysis

This present invention provides high affinity variants of human methyl binding domain 2 (hmbd2), and nucleic acids encoding the variants, capable of recognizing and/or binding to methylated dna. In particular, the hmbd2 variants of the invention recognize and/or bind a dna sequence with single methylated cpg site with high affinity.
Massachusetts Institute Of Technology

Methods and compositions for modifying genomic dna

Compositions and methods concern the sequence modification of an endogenous genomic dna region. Certain aspects relate to a method for site-specific sequence modification of a target genomic dna region in cells comprising: transfecting the cells by electroporation with a composition comprising (a) a dna oligo and (b) a dna digesting agent wherein the donor dna comprises: (i) a homologous region comprising nucleic acid sequence homologous to the target genomic dna region and (ii) a sequence modification region; and wherein the genomic dna sequence is modified specifically at the target genomic dna region..
Maxcyte, Inc.

Use of 2-chloro-3-(methylsulfanyl)-n-(1-methyl-1h-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salts for controlling unwanted plants in areas of transgenic crop plants being tolerant to hppd inhibitor herbicides

The use of 2-chloro-3-(methylsulfanyl)-n-(1-methyl-1h-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salts for controlling unwanted plants in areas of transgenic crop plants being tolerant to hppd inhibitor herbicides by containing one or more chimeric gene(s) comprising (i) a dna sequence encoding hydroxyphenylpyruvate dioxygenase (hppd) derived from a member of a group of organisms consisting of (a) avena, (b) pseudomonas, (c) synechococcoideae, (d) blepharismidae, (e) rhodococcus, (f) picrophilaceae, (g) kordia, or (ii) one or more mutated dna sequences of hppd encoding genes of the before defined organisms, preferably from pseudomonas, or (iii) one or more dna sequences encoding mutated maize (zea mays) or soybean (glycine max) hppd each being mutated as described in wo 2012/021785.. .

Chlamydia vaccine

Compositions and methods for the treatment of chlamydial infection are disclosed. The compositions provided include polypeptides that contain at least one antigenic portion of a chlamydia antigen and dna sequences encoding such polypeptides.
Government Of The Us, As Represented By The Secretary, Department Of Health And Human Services

Ancestral-specific reference genomes and uses in selecting an egg, embryo, or sperm

Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System

Ancestral-specific reference genomes and uses in identifying an individual attribute

Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System

Ancestral-specific reference genomes and uses in determining response to an active agent

Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System

Ancestral-specific reference genomes and uses in determining prognosis

Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System

Ancestral-specific reference genomes and uses in identifying a candidate for a clinical trial

Ancestry has a significant impact on the major and minor alleles found in each nucleotide position within the genome. Due to mechanisms of inheritance, ancestral-specific information contained within the genome is conserved within members of an ancestry.
Inova Health System

Method for high efficiency protein delivery into plastids

The present invention provides a recombinant dna molecule encoding a fusion protein, comprising a first dna sequence encoding a high-efficiency transit peptide operably linked to a second dna sequence encoding a passenger protein, wherein the high-efficiency transit peptide is selected from the group consisting of transit peptides of the precursors of translocon at the inner envelope membrane of chloroplasts 40 kd (prtic40), chaperonin 10-2 (prcpn10-2), fibrillin 1b (prfibrillin), atp sulfurylase 1 (praps1), atp sulfurylase 3 (praps3), 5′-adenylylsulfate reductase 3 (prapr3), stromal ascorbate peroxidase (prsapx), prtic40-e2a (a prtic40 variant), prcpn10-1-Δc7c37s (a chaperonin 10-1 variant), a functional fragment of any of the transit peptides and an equivalent thereof. And the present invention also provides a method of high efficiency delivery of a protein into plastids using the high-efficiency transit peptides..
Academia Sinica

Methods and products for expressing proteins in cells

The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the dna sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic rna molecules.
Factor Bioscience Inc.

Use of n-(1,3,4-oxadiazol-2-yl)arylcarboxamides or their salts for controlling unwanted plants in areas of transgenic crop plants being tolerant to hppd inhibitor herbicides

For controlling unwanted plants in areas of transgenic crop plants being tolerant to hppd inhibitor herbicides by containing one or more chimeric gene(s) comprising (i) a dna sequence encoding hydroxyphenylpyruvate dioxygenase (hppd) derived from a member of a group of organisms consisting of (a) avena, (b) pseudomonas, (c) synechococcoideae, (d) blepharismidae, (e) rhodococcus, (f) picrophilaceae, (g) kordia, or (ii) one or more mutated dna sequences of hppd encoding genes of the before defined organisms, preferably from pseudomonas, or (iii) one or more dna sequences encoding mutated maize (zea mays) or soybean (glycine max) hppd each being mutated as described in wo 2012/021785.. .

Compositions and methods for recognition of rna using triple helical peptide nucleic acids

Peptide nucleic acids containing thymidine and 2-aminopyridine (m) nucleobases formed stable and sequence selective triple helices with double stranded rna at physiologically relevant conditions. The m-modified pna displayed unique rna selectivity by having two orders of magnitude higher affinity for the double stranded rnas than for the same dna sequences.
The Research Foundation For The State University Of New York

Scar-less multi-part dna assembly design automation

The present invention provides a method of a method of designing an implementation of a dna assembly. In an exemplary embodiment, the method includes (1) receiving a list of dna sequence fragments to be assembled together and an order in which to assemble the dna sequence fragments, (2) designing dna oligonucleotides (oligos) for each of the dna sequence fragments, and (3) creating a plan for adding flanking homology sequences to each of the dna oligos.
The Regents Of The University Of California

Mating factor alpha pro-peptide variants

The present invention is related to mating factor α pro-peptide variants useful for the recombinant expression of polypeptides comprising a glp-1 peptide in yeasts. The invention is also related to dna sequences, vectors and host cells for use in expressing polypeptides in yeasts..
Novo Nordisk A/s

Uti fusion proteins

The present invention provides uti fusion proteins, dna sequences for producing the same, and pharmaceutical compositions and methods of using the same.. .
Takeda Pharmaceutical Company Limited

Oncolytic adenoviruses for cancer treatment

The invention relates to an oncolytic adenovirus for the treatment of cancer, containing a human dna sequence isolating a promoter conferring selective expression on an adenoviral gene. Said adenovirus can also contain a sequence that optimizes the protein translation of an adenoviral gene regulated by a promoter conferring tumor selectivity.
Dnatrix, Inc.

Novel reporter constructs for compound screening

The instant description provides reporter constructs, transgenic cells, and transgenic organisms and methods for identifying agents that can regulate gene expression and improve plant performance and yield. Compounds that increase plant performance or yield are identified by contacting a test compound with a plant cell that comprises a target promoter sequence operably linked to a polynucleotide sequence encoding a dna sequence-specific transactivator, and a reporter polynucleotide that is operably linked to a promoter sequence that is recognized by the dna sequence-specific transactivator.
Koch Biological Solutions, Llc

Error-free sequencing of dna

The invention relates to a novel method of error-free sequencing of dna. Further, the present invention provides for a four-part oligonucleotide, comprising a fixed sequence, a randomized sequence, a restriction nuclease recognition site and/or restriction site, and a primer binding site.
Fraunhofer-gesellschaft Zur Förderung Der Angewandten Forschung E.v.

Covalently closed non-coding immunomodulatory dna construct

The present invention relates to a covalently closed dna construct, a pharmaceutical composition and a vaccine and their use for the modulation of the immune system. It provides a dna construct for immunomodulation comprising a specific dna sequence..
Mologen Ag

Methods, compositions and systems for production of recombinant spider silk polypeptides

Disclosed are methods, compositions, and systems for transforming silkworms to produce spider silk and analogs of spider silk. In certain embodiments, the method may include inserting a dna sequence coding for at least a portion of a spider silk fibroin polypeptide, or an analog of a spider silk fibroin polypeptide, positioned between at least a portion of the 5′ and 3′ ends of a silkworm fibroin gene to generate a fusion gene construct having a sequence that encodes for a polypeptide comprising both spider silk fibroin and silkworm silk fibroin sequences.
Entogenetics, Inc.

Methods for the graphical representation of genomic sequence data

This disclosure provides a computational framework with related methods and systems to enhance the analysis of genomic information. More specifically, the disclosure provides for a graph-based reference genome framework, referred to as a gnomics graph model (ggm), which represents genomic sequence information in edges with nodes representing transitions between edges.
The University Of British Columbia

Reporter of genomic methylation and uses thereof

In some aspects, described herein is a dna methylation reporter. In some aspects, the dna methylation reporter comprises a promoter whose activity can be affected by exogenous methylation changes without being independently regulated by the dna methylation machinery, operably linked to a dna sequence that encodes a reporter molecule.
Whitehead Institute For Biomedical Research

Versatile extremely thermophilic bacteria for the conversion of biomass

Methods of producing ethanol by incubating lignocellulosic hydrolysates in the presence of cells of an isolated strain of thermoanaerobactor at a temperature above 70 degrees celsius. The strain of thermoanaerobactor has a 16s rdna sequence at least 99% identical a nucleic acid sequence selected from the group consisting of seq id no.
Direvo Industrial Biotechnology Gmbh



Dna Sequence topics:
  • Dna Sequence
  • Recombinant
  • Dna Sequences
  • Nucleotide
  • Sequencing
  • Oligonucleotide
  • Nucleic Acid
  • Endonuclease
  • Restriction Endonuclease
  • Polymerase
  • Amplification
  • Amino Acid
  • User Input
  • Expressions
  • Polymorphism


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    This listing is a sample listing of patent applications related to Dna Sequence for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Dna Sequence with additional patents listed. Browse our RSS directory or Search for other possible listings.


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