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Dna Sequence

Dna Sequence-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for modifying genome sequence to introduce specific mutation to targeted dna sequence by base-removal ...
National University Corporation Kobe University
November 09, 2017 - N°20170321210

The present invention provides a method of modifying a targeted site of a double stranded dna, including a step of contacting a complex wherein a nucleic acid sequence-recognizing module that specifically binds to a target nucleotide sequence in a selected double stranded dna and dna glycosylase with sufficiently low reactivity with a dna having an unrelaxed double helix structure (unrelaxed ...
Plastid transformation of maize
National University Corporation Kobe University
November 02, 2017 - N°20170314032

A method is provided for transforming monocotyledonous plants to express dna sequences of interest from plant cell plastids. The method allows the transformation of monocot plant tissue with heterologous dna constructs. The invention also provides for monocot cells in which the plastids contain heterologous dna constructs.
Ca125 gene and its use for diagnostic and therapeutic interventions
National University Corporation Kobe University
October 26, 2017 - N°20170305980

The ca125 gene has been cloned and multiple repeat sequences as well as the carboxy terminus have been identified. The ca125 molecule comprises three major domains: an extracellular amino terminal domain (domain 1); a large multiple repeat domain (domain 2); and a carboxy terminal domain (domain 3) which includes a transmembrane anchor with a short cytoplasmic domain. The amino terminal domain is dominated ...
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Stem cell gene targeting
National University Corporation Kobe University
October 19, 2017 - N°20170298384

The invention provides a method for generating a transgenic eukaryotic cell population having a modified human rosa26 locus, which method includes introducing a functional dna sequence into the human rosa26 locus of starting eukaryotic cells. Also provided are targeting vectors useful in the method, as well as a cell population and a transgenic non-human animal comprising a modified human rosa26 ...
Kit for cancer detection
Lihpao Life Science Corp.
October 12, 2017 - N°20170292164

The present invention provides a primer set and a kit containing same for analyzing a sequence of an mlh1 dna, an mlh1 mrna, and/or a cdna sequence derived from said mlh1 mrna of a subject to identify a v384 alteration of an mlh1 gene encoded protein.
Dna sequence and a mutator insertion sequence for increasing mutation rate
Academia Sinica
October 05, 2017 - N°20170283793

The invention relates to a dna sequence for increase of a mutation rate over a specific region of dna. Particularly, the invention provides a unique guanine nucleotide sequence and a mutator insertion sequence incorporated with the guanine nucleotide sequence and their applications in increasing a mutation rate.
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Genomic probes
Howard Hughes Medical Institute
September 21, 2017 - N°20170268035

Labeled probes, and methods of use thereof, comprise a cas polypeptide conjugated to grna that is specific for target nucleic acid sequences, including genomic dna sequences. The probes and methods can be used to label nucleic acid sequences without global dna denaturation. The presently-disclosed subject matter meets some or all of the above identified needs, as will become evident to ...
Vector containing centromere dna sequence and use thereof
Kaneka Corporation
September 21, 2017 - N°20170268013

A vector includes a nucleotide sequence according to any one of the following (a) to (d): (a) a nucleotide sequence set forth in seq id no: 12, 15, 18, or 21; (b) a nucleotide sequence of a nucleic acid that hybridizes with a nucleic acid consisting of a nucleotide sequence complementary to the nucleotide sequence set forth in seq id no: 12, 15, 18, or 21, under stringent ...
Chimeric antigen receptors to control hiv infection
Health And Human Services
September 21, 2017 - N°20170267739

The present disclosure is directed to novel multispecific chimeric antigen receptor (car) proteins and dna sequences encoding these proteins. The cars comprise at least two extracellular domains fused, via a transmembrane domain to a cytoplasmic signaling domain comprising two signaling domains. The disclosure further relates to nucleic acids encoding the novel cars, to host cells expressing the novel cars, and ...
Oncolytic adenovirus encoding a therapeutic protein or active fragment
Psioxus Therapeutics Limited
September 21, 2017 - N°20170266243

The present disclosure provides a oncolytic adenovirus with selectivity for cancer cells, wherein the adenovirus comprises a transgene under the control of a promoter endogenous to the virus, wherein the transgene comprises a dna sequence encoding a membrane anchored anti-cd3 antibody or a binding fragment thereof, compositions comprising same, methods of generating the viruses, and use of the viruses and ...
Methods for variant detection
Integrated Dna Technologies, Inc.
September 14, 2017 - N°20170260583

The invention can be used to provide a more efficient and less error-prone method of detecting variants in dna, such as snps and indels. The invention also provides a method for performing inexpensive multiplex assays. The invention also provides methods for detection of dna sequences altered after cleavage by a targetable endonuclease, such as the crispr cas9 protein from the ...
Dividing of reporter proteins by dna sequences and its application in site specific recombination
Integrated Dna Technologies, Inc.
September 07, 2017 - N°20170253938

Methods and constructs for inserting an intron into a reporter protein coding sequence in a eukaryotic cell and their application of monitoring and reporting genomic modifications are provided. Various related compositions, cells and kits are also provided.
Methods for variant detection
Integrated Dna Technologies
September 07, 2017 - N°20170253925

The invention can be used to provide a more efficient and less error-prone method of detecting variants in dna, such as snps and indels. The invention also provides a method for performing inexpensive multiplex assays. The invention also provides methods for detection of dna sequences altered after cleavage by a targetable endonuclease, such as the crispr cas9 protein from the ...
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Dna sequence, and recombinant preparation of group 4 major allergens from cereals
Merck Patent Gmbh
August 31, 2017 - N°20170246317

The present invention relates to the provision of dna sequences of group 4 mayor allergens from cereals. The invention also encompasses fragments, new combinations of partial sequences and point mutants having a hypoallergenic action. The recombinant dna molecules and the derived polypeptides, fragments, new combinations of partial sequences and variants can be utilised for the therapy of pollen-allergic diseases. The proteins ...
Genetically stable recombinant modified vaccinia ankara (rmva) vaccines and methods of preparation thereof
City Of Hope
August 31, 2017 - N°20170246292

A vaccine comprising an immunologically effective amount of recombinant modified vaccinia ankara (rmva) virus which is genetically stable after serial passage and produced by a) constructing a transfer plasmid vector comprising a modified h5 (mh5) promoter operably linked to a dna sequence encoding a heterologous foreign protein antigen, wherein the expression of said dna sequence is under the control of ...
Sidt1 gene controlling determinate growth habit in sesame and snp molecular marker thereof
Henan Sesame Research Center, Henan Academy Of Agricultural Sciences
August 17, 2017 - N°20170233831

A sidt1 gene controlling a determinate growth habit of sesame, the gene having a length of 1809 bp and including four exons and three introns. The sidt1 gene is located on the fourth chromosome of sesame and in an 18. 0-19. 2 cm interval of the eighth linkage group on an snp genetic map of sesame. The dna sequence of the sidt1 gene ...
Compositions and methods for modifying genomes
Benson Hill Biosystems, Inc.
August 17, 2017 - N°20170233756

Compositions and methods for modifying genomic dna sequences are provided. The methods produce double-stranded breaks (dsbs) at pre-determined target sites in a genomic dna sequence, resulting in mutation, insertion, and/or deletion of dna sequences at the target site(s) in a genome. Compositions comprise dna constructs comprising nucleotide sequences that encode a cpf1 or csm1 protein operably linked to ...
Compositions and methods for transcription-based crispr-cas dna editing
The Rockefeller University
August 17, 2017 - N°20170233729

Provided are compositions and methods for cleaving a dna sequence in a cell. The methods involve comprising introducing into a cell a recombinant vector containing a clustered regularly interspaced short palindromic repeats (crispr) system. The system includes a crispr rna (crrna) targeted to a dna sequence in the cell that is operatively linked to a promoter; and crispr-associated enzymes (cas) 10, ...
Finding relatives in a database
23andme, Inc.
August 10, 2017 - N°20170228498

Determining relative relationships of people who share a common ancestor within at least a threshold number of generations includes: receiving recombinable deoxyribonucleic acid (dna) sequence information of a first user and recombinable dna sequence information of a plurality of users; processing, using one or more computer processors, the recombinable dna sequence information of the plurality of users in parallel; determining, ...
Biomarkers for rheumatoid arthritis and usage thereof
Bgi Shenzhen
August 10, 2017 - N°20170226565

Biomarkers and methods for predicting risk of a disease in particular ra are provided. Sequences of dna are obtained. The dna may be extracted from a sample that is collected from a subject. A relative abundance of a biomarker is then calculated based on the sequences of the dna. The biomarker comprises a dna sequence in a genome of lactobacillus ...
Solubility and affinity tag for recombinant protein expression and purification
Bgi Shenzhen
August 10, 2017 - N°20170226489

Systems and methods of coding for and isolating a fusion protein are provided. The fusion protein may be expressed by a dna sequence and comprise an adenylate kinase linked by its carboxy-terminus to a biologically active polypeptide or protein. Later processing steps include isolating the biologically active polypeptide or protein via affinity elution of the fusion proteins with substrate analog ...
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