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Dna Sequence

Dna Sequence-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Computer-implemented method for designing synthetic dna, and terminal, system and computer-readable medium for the same
June 21, 2018 - N°20180173849

Data representative of an entire synthetic dna barcode sequence that is calculated based on the calculated synthetic dna sequence. A terminal, system and computer-readable medium are also provided..
NEW Improvements in and relating to nucleic acid probes and hybridisation methods
June 21, 2018 - N°20180171398

The invention provides a method of nucleic acid sequence hybridisation comprising the steps of: a) hybridising one or more samples comprising nucleic acids containing a region of interest with at least one probe nucleic acid sequence; and b) adding to the samples a non-deoxy ribonucleic acid molecule, before or during step a). And use of non-deoxy ribonucleic molecules to block ...
NEW Subtilase variants and polynucleotides encoding same
June 21, 2018 - N°20180171317

The present invention relates to subtilase variants suitable for use in, e.g., cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions. The present invention also relates to isolated dna sequences encoding the variants, expression vectors, host cells, and methods for producing and using the variants of the invention..
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Systems and methods for epigenetic sequencing
The General Hospital Corporation
June 07, 2018 - N°20180155778

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence.
Systems and methods for epigenetic sequencing
The General Hospital Corporation
June 07, 2018 - N°20180155777

The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence.
Multiply-substituted protease variants
Danisco Us Inc
June 07, 2018 - N°20180155702

Novel protease variants derived from the dna sequences of naturally-occurring or recombinant non-human proteases are disclosed. The variant proteases, in general, are obtained by in vitro modification of a precursor dna sequence encoding the naturally-occurring or recombinant protease to generate the substitution of a plurality of amino acid residues in the amino acid sequence of a precursor protease.
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Compositions and methods for modifying genomes
Benson Hill Biosystems, Inc.
May 31, 2018 - N°20180148735

Compositions and methods for modifying genomic dna sequences are provided. The methods produce double-stranded breaks (dsbs) at pre-determined target sites in a genomic dna sequence, resulting in mutation, insertion, and/or deletion of dna sequences at the target site(s) in a genome.
Methods and systems for predicting dna accessibility in the pan-cancer genome
Nant Holdings Ip, Llc
May 24, 2018 - N°20180144261

Techniques are provided for predicting dna accessibility. Dnase-seq data files and rna-seq data files for a plurality of cell types are paired by assigning dnase-seq data files to rna-seq data files that are at least within a same biotype.
Methods of lowering the error rate of massively parallel dna sequencing using duplex consensus sequencing
University Of Washington Through Its Center For Commercialization
May 24, 2018 - N°20180142293

Next generation dna sequencing promises to revolutionize clinical medicine and basic research. However, while this technology has the capacity to generate hundreds of billions of nucleotides of dna sequence in a single experiment, the error rate of approximately 1% results in hundreds of millions of sequencing mistakes.
Modular dna-binding domains and methods of use
May 24, 2018 - N°20180141979

The present invention refers to methods for selectively recognizing a base pair in a dna sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a dna sequence and, to dna which is modified so that it can be specifically recognized by a polypeptide and to uses of the polypeptide and dna in specific ...
Oncolytic adenovirus encoding a b7 protein
Psioxus Therapeutics Limited
May 24, 2018 - N°20180140649

The present disclosure provides a replication competent oncolytic adenovirus with selectivity for cancer cells, wherein the adenovirus comprises a transgene under the control of a promoter endogenous to the virus, wherein the transgene comprises a dna sequence encoding a b7 protein or an active fragment thereof, compositions comprising same, methods of generating the viruses, and use of the viruses and ...
Genomic-based virus detection
Sap Se
May 17, 2018 - N°20180137238

A plurality of deoxyribonucleic acid (dna) reads is received, where each dna read represents a portion of a dna sequence of a patient's dna sample. The plurality of dna reads is assembled into an aligned dna sequence based on a human reference dna sequence.
Delivery of therapeutic agent
Codiak Biosciences, Inc.
May 17, 2018 - N°20180135056

A method of producing nanovesicles comprising an oligonucleotide inhibitor to an oncogene or a proto-oncogene or the gene product thereof, said method comprises a) introducing a dna sequence encoding an oligonucleotide capable of inhibiting a human oncogenic or proto-oncogenic transcription factor, into a mammalian cell; b) allowing the cell to express said inhibitor oligonucleotide; and c) obtaining nanovesicles containing said ...
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System for stable gene expression
Board Of Trustees, Southern Illinois University
April 19, 2018 - N°20180105833

An inducible expression cassette for controlled expression of multiple genes includes the dna sequences of a bidirectional promoter inserted between two dna sequences. Transfection into a host cell and the two dna sequences encode genes of interest, provides one dna sequence expressed constitutively and manipulation of the expression of the other dna sequence.
Method for rna-guided endonuclease-based dna assembly
Massachusetts Institute Of Technology
April 19, 2018 - N°20180105806

The invention provides a novel approach to facilitate assembly of dna molecules. This approach utilizes rna-guided endonucleases, capable of targeting any dna sequence, which cleave dna and generate dna fragments characterized by single stranded overhangs.
Enhanced processes and reagents for host engineering
Invista North America S.a.r.l.
April 12, 2018 - N°20180100160

Nonnaturally occurring host cells altered to increase their ability to transfer genetic molecules into the host cells as compared to an unaltered host cell are provided. Also provided are methods for identifying endogenous loci of a host cell which inhibit transformation efficiency and/or electroporation of genetic molecules into the cell as well as methods for producing nonnaturally occurring host ...
Chimeric peptides against htlv-1
April 12, 2018 - N°20180099042

A method of immunizing against htlv-1 is disclosed. The method may include preparing a dna sequence corresponding to a chimeric peptide which may have immunogenic epitopes of htlv-1.
Method for analysing nuclease hypersensitive sites
Hypergenomics Pte. Limited
March 29, 2018 - N°20180087089

The present invention provides a method for analysing nuclease hypersensitive sites which method comprises: i) cleaving a nucleic acid sample comprising chromatin at multiple nuclease hypersensitive sites with a first sequence specific restriction enzyme to introduces a staggered cut and leave a single chain 3′ or 5′ overhang in a double stranded dna; ii) optionally isolating substantially free dna from ...
Human igm antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system
March 29, 2018 - N°20180086821

Antibodies, particularly human antibodies, are disclosed having activity in treatment of demyelinating diseases and diseases of the central nervous system. Neuromodulatory agents are provided comprising a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, and active fragments, monomers and combinations thereof having one or more ...
Enrichment of nucleic acids by complimentary capture
The Johns Hopkins University
March 22, 2018 - N°20180080062

Assays can be used to detect mutations found in neoplasms of the pancreas, as well as for other neoplasms and other uses. Nucleic acids can be captured from body fluids such as cyst fluids.
Cas 9 retroviral integrase and cas 9 recombinase systems for targeted incorporation of a dna sequence into ...
Exeligen Scientific, Inc.
March 22, 2018 - N°20180080051

The instant disclosure relates to the use of engineered proteins such as cas9, cpf1, tale and zinc finger proteins attached with a viral integrases, recombinase, or transposase in order to deliver a dna sequence of interest (or gene of interest) to a targeted site in a genome of a cell or organism. The use of a cas9 that is inactive ...
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