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Dna Polymerase

Dna Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Dna polymerases with increased 3'-mismatch discrimination
Roche Molecular Systems, Inc.
February 15, 2018 - N°20180044648

Disclosed are mutant dna polymerases having increased 3′-mismatch discrimination relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e. G., for production of the mutant dna polymerases.
Recombinant polymerases with increased phototolerance
Pacific Biosciences Of California, Inc.
February 15, 2018 - N°20180044647

Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties include increased resistance to photodamage, and can also include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic ...
Amplification and analysis of whole genome and whole transcriptome libraries generated by a dna polymerization ...
Takara Bio Usa, Inc.
February 01, 2018 - N°20180030522

The present invention regards a variety of methods and compositions for whole genome amplification and whole transcriptome amplification. In a particular aspect of the present invention, there is a method of amplifying a genome comprising a library generation step followed by a library amplification step. In specific embodiments, the library generating step utilizes specific primer mixtures and a dna polymerase, ...
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Dna polymerases with improved activity
Roche Molecular Systems, Inc.
January 11, 2018 - N°20180010107

Provided are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of primer extension methods. Also provided are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e. G., for production of the dna polymerases.
Dna polymerases with improved activity
Roche Molecular Systems, Inc.
January 11, 2018 - N°20180010106

Disclosed are dna polymerases having increased reverse transcriptase efficiency relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e. G., for production of the dna polymerases.
Reagents and methods of pcr
Brandeis University
January 04, 2018 - N°20180002739

Modified double-stranded oligonucleotides that have terminal regions on each of their strands, that have a hybrid length of 6-50 nucleotides long, that have a melting temperature tm of at least 32° c., and that include 2-4 modifying groups, each covalently attached to a different terminal region, preferably to a terminal nucleotide, said modifying groups being polycyclic substituents that do not ...
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Recombinase polymerase amplification
Alere San Diego, Inc.
November 30, 2017 - N°20170342473

This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed ...
Method for detecting and quantifying biomaterials by using activity of nucleic acid polymerase regulated by ...
Korea Advanced Institute Of Science And Technology
November 23, 2017 - N°20170335381

The present invention relates to a method of detecting and quantifying biomolecules using nucleic acid polymerase activity controlled by the target molecule, and more particularly to a method for detecting or quantifying biomolecules, which can detect and quantify nucleic acids, proteins, small-molecular substances, physiologically active substances (enzymatic activities), etc., with high sensitivity, based on the change in dna polymerase activity ...
Pyrimidine phosphonic acid esters
Concert Pharmaceuticals, Inc.
November 23, 2017 - N°20170334937

This invention relates to compounds of formula (a), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a viral dna polymerase inhibitor.
Recombinant polymerases for improved single molecule sequencing
Pacific Biosciences Of California, Inc.
November 16, 2017 - N°20170327801

Provided are compositions comprising recombinant dna polymerases that include amino acid substitutions, insertions, deletions, and/or exogenous features that confer modified properties upon the polymerase for enhanced single molecule sequencing. Such properties can include enhanced metal ion coordination, reduced exonuclease activity, reduced reaction rates at one or more steps of the polymerase kinetic cycle, decreased branching fraction, altered cofactor selectivity, ...
Method of determining the nucleotide sequence of oligonucleotides and dna molecules
Life Technologies Corporation
November 09, 2017 - N°20170321269

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of dna polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a dna fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base ...
Modified nucleotide reagents
Pacific Biosciences Of California, Inc.
November 09, 2017 - N°20170321268

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
Recombinase polymerase amplification
Alere San Diego Inc.
November 09, 2017 - N°20170321262

This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and ...
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Method of nucleic acid sequence determination
November 02, 2017 - N°20170314072

Provided are sequencing-by-binding methods of detecting cognate nucleotides using a crippled dna polymerizing enzyme that possesses the ability to bind the next correct nucleotide downstream of a primer in a template-dependent fashion, but does not possess the activity needed to promote phosphodiester bond formation. Use of the crippled dna polymerase permits interrogation of one nucleotide at a time, without incorporation ...
Sequencing method employing ternary complex destabilization to identify cognate nucleotides
November 02, 2017 - N°20170314064

Provided are methods and systems for detecting formation of nucleotide-specific ternary complexes comprising a dna polymerase, a nucleic acid, and a nucleotide complementary to the templated base of the primed template nucleic acid. The methods and systems facilitate determination of the next correct nucleotide without requiring chemical incorporation of the nucleotide into the primer. These results can even be achieved ...
Compositions, methods, and kits for synthesis and detection of nucleic acids
Life Technologies Corporation
October 12, 2017 - N°20170292144

Compositions, methods, and kits for synthesizing, detecting, and/or quantifying nucleic acids are provided herein. Embodiments comprise a nucleic acid amplification composition comprising a thermostable dna polymerase and agents which improve nucleic acid synthesis, amplification, detection, and/or quantification of nucleic acid targets in a crude extract or crude lysate sample.
Compositions and methods relating to synthetic rna polynucleotides created from synthetic dna oligonucleotides
New England Biolabs, Inc.
October 05, 2017 - N°20170283797

Compositions and methods are provided for forming a single rna polynucleotide from a plurality of dna oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. Dna polymerase, rna polymerase and single stranded (ss) dna oligonucleotides are combined where each dna oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss ...
Polymerases
Illumina Cambridge Limited
September 28, 2017 - N°20170275602

Modified dna polymerases have an affinity for dna such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate dna templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-dna complexes in each reaction cycle. The modified polymerases may be used in a number of dna ...
Ph measurement for sequencing of dna
The Board Of Trustees Of The Leland Stanford Junior University
September 21, 2017 - N°20170268053

The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base (dntp) in the presence of appropriate reagents (dna polymerase, and ...
Integrated on chip detector and zero waveguide module structure for use in dna sequencing
International Business Machines Corporation
September 14, 2017 - N°20170263801

A semiconductor structure for use in single molecule real time dna sequencing technology is provided. The structure includes a semiconductor substrate including a first region and an adjoining second region. A photodetector is present in the first region and a plurality of semiconductor devices is present in the second region. A contact wire is located on a surface of a ...
Method for improving nucleic acid synthesis reaction
Takara Bio Inc.
September 14, 2017 - N°20170260578

Provided are the following: a method, for improving reactivity of an acid synthesis reaction, comprising a step for adding an ω-amino acid to a reaction solution; a composition, for a nucleic acid synthesis reaction, comprising dna polymerase, reaction buffer, at least one primer, at least one deoxyribonucleoside triphosphate, and an ω-amino acid; and a reaction buffer, ...
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