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Dna Polymerase

Dna Polymerase-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Recombinase polymerase amplification
Alere San Diego, Inc.
November 30, 2017 - N°20170342473

This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes. Further, the improved processivity of the disclosed ...
Method for detecting and quantifying biomaterials by using activity of nucleic acid polymerase regulated by ...
Korea Advanced Institute Of Science And Technology
November 23, 2017 - N°20170335381

The present invention relates to a method of detecting and quantifying biomolecules using nucleic acid polymerase activity controlled by the target molecule, and more particularly to a method for detecting or quantifying biomolecules, which can detect and quantify nucleic acids, proteins, small-molecular substances, physiologically active substances (enzymatic activities), etc., with high sensitivity, based on the change in dna polymerase activity ...
Pyrimidine phosphonic acid esters
Concert Pharmaceuticals, Inc.
November 23, 2017 - N°20170334937

This invention relates to compounds of formula (a), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a viral dna polymerase inhibitor.
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Method of determining the nucleotide sequence of oligonucleotides and dna molecules
Life Technologies Corporation
November 09, 2017 - N°20170321269

The present invention relates to a novel method for analyzing nucleic acid sequences based on real-time detection of dna polymerase-catalyzed incorporation of each of the four nucleotide bases, supplied individually and serially in a microfluidic system, to a reaction cell containing a template system comprising a dna fragment of unknown sequence and an oligonucleotide primer. Incorporation of a nucleotide base ...
Modified nucleotide reagents
Pacific Biosciences Of California, Inc.
November 09, 2017 - N°20170321268

Labeled nucleotide analogs comprising at least one avidin protein, at least one dye-labeled compound, and at least one nucleotide compound are provided. The analogs are useful in various fluorescence-based analytical methods, including the analysis of highly multiplexed optical reactions in large numbers at high densities, such as single molecule real time nucleic acid sequencing reactions. The analogs are detectable with ...
Recombinase polymerase amplification
Alere San Diego Inc.
November 09, 2017 - N°20170321262

This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes, thus offering easy and affordable implementation and ...
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Method of nucleic acid sequence determination
Illumina, Inc.
November 02, 2017 - N°20170314072

Provided are sequencing-by-binding methods of detecting cognate nucleotides using a crippled dna polymerizing enzyme that possesses the ability to bind the next correct nucleotide downstream of a primer in a template-dependent fashion, but does not possess the activity needed to promote phosphodiester bond formation. Use of the crippled dna polymerase permits interrogation of one nucleotide at a time, without incorporation ...
Sequencing method employing ternary complex destabilization to identify cognate nucleotides
Illumina, Inc.
November 02, 2017 - N°20170314064

Provided are methods and systems for detecting formation of nucleotide-specific ternary complexes comprising a dna polymerase, a nucleic acid, and a nucleotide complementary to the templated base of the primed template nucleic acid. The methods and systems facilitate determination of the next correct nucleotide without requiring chemical incorporation of the nucleotide into the primer. These results can even be achieved ...
Compositions, methods, and kits for synthesis and detection of nucleic acids
Life Technologies Corporation
October 12, 2017 - N°20170292144

Compositions, methods, and kits for synthesizing, detecting, and/or quantifying nucleic acids are provided herein. Embodiments comprise a nucleic acid amplification composition comprising a thermostable dna polymerase and agents which improve nucleic acid synthesis, amplification, detection, and/or quantification of nucleic acid targets in a crude extract or crude lysate sample.
Compositions and methods relating to synthetic rna polynucleotides created from synthetic dna oligonucleotides
New England Biolabs, Inc.
October 05, 2017 - N°20170283797

Compositions and methods are provided for forming a single rna polynucleotide from a plurality of dna oligonucleotides in a single reaction chamber using combined reagents in a single step reaction. Dna polymerase, rna polymerase and single stranded (ss) dna oligonucleotides are combined where each dna oligonucleotide has one or more sequence modules, wherein one sequence module in the first ss ...
Polymerases
Illumina Cambridge Limited
September 28, 2017 - N°20170275602

Modified dna polymerases have an affinity for dna such that the polymerase has an ability to incorporate one or more nucleotides into a plurality of separate dna templates in each reaction cycle. The polymerases are capable of forming an increased number of productive polymerase-dna complexes in each reaction cycle. The modified polymerases may be used in a number of dna ...
Ph measurement for sequencing of dna
The Board Of Trustees Of The Leland Stanford Junior University
September 21, 2017 - N°20170268053

The present method involves sequencing by synthesis in which a template strand having an attached primer is immobilized in a small volume reaction mixture. In one embodiment, the reaction mixture is in contact with a sensitive heat sensor, which detects the heat of reaction from incorporation of a complementary base (dntp) in the presence of appropriate reagents (dna polymerase, and ...
Integrated on chip detector and zero waveguide module structure for use in dna sequencing
International Business Machines Corporation
September 14, 2017 - N°20170263801

A semiconductor structure for use in single molecule real time dna sequencing technology is provided. The structure includes a semiconductor substrate including a first region and an adjoining second region. A photodetector is present in the first region and a plurality of semiconductor devices is present in the second region. A contact wire is located on a surface of a ...
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Affenadenovirus (gorilla) or adenoviral vectors and methods of use
Genvec, Inc.
August 31, 2017 - N°20170246318

The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pix protein, dna polymerase protein, penton protein, hexon protein, and/or fiber protein.
F. oxysporum f.sp. melonis race 1,2-resistant melons
Syngenta Participations Ag
August 24, 2017 - N°20170238487

Methods for conveying fusarium oxysporum f. Sp. Melonis (fom) race 1,2 resistance into non-resistant melon germplasm are provided. In some embodiments, the methods include introgressing fom race 1,2 resistance into a non-resistant melon using one or more nucleic acid markers for marker-assisted selection among melon lines to be used in a melon breeding program, wherein the markers are linked to fom race 1,2 ...
In vitro recombination method
Synthetic Genomics, Inc.
August 17, 2017 - N°20170233764

The present invention relates, e. G., to in vitro method, using isolated protein reagents, for joining two double stranded (ds) dna molecules of interest, wherein the distal region of the first dna molecule and the proximal region of the second dna molecule share a region of sequence identity, comprising contacting the two dna molecules in a reaction mixture with (a) ...
Simian (gorilla) adenovirus or adenoviral vectors and methods of use
Genvec, Inc.
July 27, 2017 - N°20170211097

The invention provides an adenovirus or adenoviral vector characterized by comprising one or more particular nucleic acid sequences or one or more particular amino acid sequences, or portions thereof, pertaining to, for example, an adenoviral pix protein, dna polymerase protein, penton protein, hexon protein, and/or fiber protein.
Antibodies that bind thermophilic dna polymerases
Thermo Fisher Scientific Baltics Uab
July 20, 2017 - N°20170204454

This disclosure relates to antibodies that bind thermophilic family b dna polymerases. Related uses, methods, and compositions are also provided.
Thermophilic dna polymerase mutants
Thermo Fisher Scientific Baltics Uab
July 20, 2017 - N°20170204384

This disclosure relates to thermophilic family b dna polymerases comprising a neutral amino acid residue at a certain position near the c-terminus of the catalytic domain, which corresponds to a position occupied by a basic amino acid residue in wild-type pfu polymerase. Related uses, methods, and compositions are also provided. In some embodiments, the polymerases comprise a 3′-5′ ...
Nras gene mutation detection kit
Jiaxing Accb Diagnostics Ltd.
July 13, 2017 - N°20170198355

This invention relates to a kit for detecting nras gene mutation, and this kit can be used to detect cancer-related nras gene mutation. The said kit comprises: (1) the internal reference detection reagent, which includes the internal reference gene specific primers, internal reference gene specific probes and dntp solution; (2) the nras mutation detection reagent, which includes the nras gene mutant type ...
Dna polymerases with improved activity
Roche Molecular Systems, Inc.
July 06, 2017 - N°20170191044

Disclosed are dna polymerases having increased reverse transcriptase efficiency, mismatch tolerance, extension rate and/or tolerance of rt and polymerase inhibitors relative to a corresponding, unmodified polymerase. The polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombinant nucleic acids, vectors, and host cells, which are useful, e. G., for production of ...
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