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 Vapor deposition of metal oxides, silicates and phosphates, and silicon dioxideMetal silicates or phosphates are deposited on a heated substrate by the reaction of vapors of alkoxysilanols or alkylphosphates along with reactive metal amides, alkyls or alkoxides. For example, vapors of tris(tert-butoxy)silanol react with vapors of tetrakis(ethylmethylamido) hafnium to deposit hafnium silicate on surfaces heated to 300° c. President And Fellows Of Harvard College |
 Biocompatible and bioabsorbable derivatized chitosan compositionsThe invention relates to biocompatible, bioabsorbable derivatized non-crosslinked chitosan compositions optionally crosslinked to gelatin/collagen by 1-ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (edc) for biomedical use and methods of making and testing such compositions, including a modified acute systemic toxicity test. The compositions comprise derivatized chitosan reacetylated to a degree of n-deacetylation (dda) of between about 15% and 40%. Hemcon Medical Technologies, Inc. |
 Method for preparing ibrutinibProvided is a method for preparing ibrutibin (i), and steps of preparing same comprise: 4-benzyloxybenzoyl chloride (ii) is used as a raw material, condensation and methoxidation reactions occur among 4-benzyloxybenzoyl chloride (ii), malononitrile, and dimethyl sulfate to generate 4-benzyloxyphenyl(methoxy)vinylidenedicyanomethane (iii), pyrazole cyclization occurs between the intermediate (iii) and 1-(3r-hydrazino-1-piperidino)-2-propylene-1-ketone (iv) to acquire 1-[(3r)-[3-(4-benzyloxyphenyl)-4-nitrile-5 -amino-1h-pyrazole]-1-piperidino]-2 propylene-1-ketone (v), and pyrimidine cyclization occurs between an intermediate (v) and a cyclizing agent to prepare ibrutinib (i). In the preparation method, the raw material is readily available, and the process is simple, economical, environmentally friendly, and is suitable for industrial production.. Suzhou Miracpharma Technology Co., Ltd. |
 Novel intermediate of tapentadolThe present invention relates to novel carbamate intermediate of formula (ii), process for its preparation and process for its conversion into 3-[(1r,2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol, tapentadol and its pharmaceutically acceptable salts.. . Sun Pharma Advanced Research Company |
 Structure directing agent for improved synthesis of zeolitesThe present invention relates to structure directing agents for synthesis of crystalline materials generally known as zeolites, by use of an enhanced content of the trans isomer of a 3,5-dimethyl-n,n-dimethylpiperidinium cation together with the conventional oxides used to form zeolites.. . Sachem, Inc. |
 Partial skull replacements capable of monitoring in real time and delivering substances into brain tissue, and uses thereofThe present invention relates to a partial skull replacement consisting of polydimethylsiloxane (pdms) and a method of monitoring biological tissues within a skull using the partial skull replacement. The method of monitoring using the partial skull replacement of the present invention has a minimal influence on intracranial pressure and cerebrospinal fluid flow as compared to a conventional cranial window technique using glass, and, by way of visualizing biological tissues within a skull with enhanced clarity, is expected to be usefully employed as a method of monitoring biological tissues within the skull.. Institute For Basic Science |
 Thermoplastic article with active agentAn extruded water-soluble article made is from a homogeneous material that includes a water-soluble polymer having an extrusion temperature of 50 to 150° c. The article further includes between 0.1% to 50% by weight of an active agent. Kimberly-clark Worldwide, Inc. |
 Compositions and therapeutic methods for the treatment of complement-associated diseasesThe invention comprises methods of modulating the complement cascade in a mammal and for treating and/or preventing diseases and disorders associated with the complement pathway by administering a compound of formula i or formula ii, such as, for example, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3h)-one or a pharmaceutically acceptable salt thereof.. . Resverlogix Corp. |
 CombinationsThe present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1h-pyrazol-5-yl]amino}-4-pyridinyl)amino]-n-(methyloxy)benzamide, or a pharmaceutically acceptable salt thereof, and n-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2h-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof.. Glaxosmithkline Llc |
 Method and device for indicating moisture based on bis(glyoxime)-transition metal complexesCompositions that include bis(glyoxime)-transition metal complexes bound to metal oxide solid supports are provided. In some embodiments the compositions include nickel dimethylglyoxime and the metal oxide supports can be alumina or silica. 3m Innovative Properties Company |
The invention describes the process by which a standard mixture of organic compounds are spiked and retained onto a composite sorbent matrix for the controlled generation of a standard in fluid above the spiked matrix either in gas (headspace) or aqueous phase which is contained in portable vials. The novelty of the aforementioned composite matrix stems from the combination of an immobilizing liquid phase such as silicone oil or a polyacrylonitrile solution, and solid, porous particles such as polystyrene-co-divinylbenzene (ps-dvb) or hydrophilic/lipophilic balance (hlb) particles to strongly retain the spiked standards facilitating high capacity which translates into prolonged use as a source of calibrant. |
The present invention relates to new crystalline forms of cabazitaxel of formula (i). Specifically, the present invention provides four new crystalline solvate forms of cabazitaxel, designated as form s2 (solvate with 2-methyltetrahydrofuran), form s4 (solvate with tent-butyl acetate), form s5 (solvate with dimethylcarbonate) and form s6 (solvate with n-methyl-2-pyrrolidinone). Indena S.p.a. |
Synthesis of hyperbranched amphiphilic polyester and theranostic nanoparticles thereof A method of making a hyperbranched amphiphilic polyester compound includes drying under vacuum a mixture of 2-(4-hydroxybutyl)-malonic acid and p-toluene sulphonic acid as catalyst. The vacuum is then released with a dry inert gas after drying. University Of Central Florida Research Foundation, Inc. |
Compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine Pharmaceutical compositions of 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]piperazine and pharmaceutically acceptable acid addition salts thereof adapted so that release does not take place in the stomach is provided.. . H. Lundbeck A/s |
(i) a linear polymer including a dimethylsiloxane group which has a vinyl end substituent and/or a linear polymer including a methylphenylsiloxane group which has a vinyl end substituent; and (ii) at least one vinyl-based resin selected from the group consisting of a vinyl-based vimq resin. An led package comprising the encapsulant is also disclosed.. |
Method for preparing ionic liquid having carboxylic acid anion using microreactor The present invention relates to a method for preparing an ionic liquid having a carboxylic acid anion using a microreactor. More specifically, the present invention relates to a method for preparing, with high efficiency, an ionic liquid having a carboxylic acid anion as shown in fig. Chemtech Research Incorporation |
Disclosed is a method for preparing a heterogenous corneal material, wherein during the whole preparation process, different concentrations of glycerol are used to achieve that the heterogenous corneal graft has the transparent, properties of no viruses and cells; resistance to degradation and immunogenicity of collagen can be further reduced by collagen cross-linking; and under the whole eye saving, cross-linkers 1-(3-dimethylaminopropyl)-3-ethylcarbodi imide (edc) and n-hydroxy sulfosuccinimide (nhs) are used for cross-linking, thus enabling the form thereof to be closer to that of a fresh cornea and improving biomechanical properties thereof. The method can prepare a heterogenous corneal material with a high transparency, a low immunogenicity and a good bioactivity and biocompatibility, and can maintain that the three-dimensional structure of collagen is close to that of a fresh cornea. Youvision Biotech Co., Ltd. |
The invention relates to a method for dissolving the components of gel forming materials suitable for use in wound care comprising the steps of admixing said components with an ionic liquid. The ionic liquid may be selected from the group of tertiary amine n-oxides, n,n-dimethyl formamide/nitrogen tetroxide mixtures, dimethyl sulphoxide/paraformaldehyde mixtures and solutions of limium chloride in n,n-dimethyl acetamide or n-methyl pyrrolidone.. Convatec Technologies Inc. |
The present invention provides a compound of the formula i: wherein a is: and w, y, x, r1, r2, r3, and r4 are as defined herein, or a pharmaceutically acceptable salt thereof, for use as an inhibitor of the ep4 receptor.. . Eli Lilly And Company |
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Integrated process for converting methane to aromatics and other chemicals Systems and methods for integrated production of aromatics and other chemicals are described. Systems and methods may include a process for producing benzene, methanol, butanals, dimethyl ethers, olefins and other chemicals that includes providing methane to a first reactor to produce a first product stream comprising benzene and hydrogen; recovering benzene and mixing the first product stream with a carbon dioxide and/or steam feed stream; providing the combined benzene depleted first product stream and carbon dioxide and/or steam feed stream to a second reactor to produce a second product stream comprising synthesis gas, water and unconverted methane and carbon dioxide; and providing the synthesis gas to a third reactor to produce a third product stream comprising methanol, butanals, and other chemicals.. Saudi Basic Industries Corporation |
Disclosed are cement products, methods of forming cement using the cement product, and methods of using the cement product in orthopedic and dental applications. Generally, the disclosed cement product includes a first component and a second component. Pioneer Surgical Technology, Inc. |
Cerclage pessary containing progesterone homogeneously distributed in the pessary body providing a prolonged, sustained and continuous release for a period of at least 6 months, wherein the pessary consists of dimethylsiloxane elastomer with rtv (room temperature vulcanization) mechanism, the progesterone amount is from 20% to 30% w/w, relative to pessary weight and the ratios of the polymers forming the matrix is from 6:1 to 14 1. The cerclage pessary is useful for the prevention of preterm birth. Laboratorios Andromaco S.a. |
Methods and formulations for infusing bioavailable flavonoid tinctures into food, beverage, cosmetic or drug products with minimal or no effect on the alcohol by volume of the product is provided. A flavonoid tincture includes an amount of trans-resveratrol, pterostilbene, quercetin, or combinations thereof, mixed with a solvent of pure, or majority by weight, ethanol or dimethyl sulfoxide the tincture is added to various food and beverages to make a bioavailable amount of flavonoids to be absorbed and metabolized by the body providing demonstrated health benefits.. Heart Healthy Spirits, Llc |
Homogenous immunoassay with compensation for background signal Homogeneous immunoassays that allow for compensation of background signals inherent in samples and reagents. The use of homogeneous immunoassays for the detection of the presence or amount of symmetrical dimethyl arginine (sdma) in biological samples. Idexx Laboratories, Inc. |
Antibodies, immunoassay methods and kits for the detection and determination of 3,4,-dichloro-n-[(1-(dimethylamino)cyclohexyl)methyl]benzamide and 3,4,-dichloro-n-[(1-(methylamino)cyclohexyl)methyl]benzamide, as well as the precursory immunogens, are described.. . Randox Laboratories Ltd. |
Methods and compositions are provided for removing a residue of resin from the surface of equipment. In one embodiment, the methods comprise: providing a cleaning solution comprising a ph-adjusting agent, a chemical solvent, and water, wherein the chemical solvent is selected from the group consisting of β-lactam, γ-lactam, δ-lactam, ε-lactam, 2-pyrrolidone, n-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone (dmi), caprolactam, cyclohexanone, cyclopentanone, β-butyrolactone, γ-butyrolactone, δ-decalactone, γ-valerolactone, ε-caprolactone, butylene carbonate, propylene carbonate, and ethylene carbonate, any combination thereof, and any derivative thereof; allowing the cleaning solution to contact a surface at least partially coated with a layer of resin; and allowing the cleaning solution to at least partially dissolve the resin.. Halliburton Energy Services, Inc. |
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)-n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits mdm2 and has anti-tumor activity. Daiichi Sankyo Company, Limited |
A novel combination comprising the vegfr inhibitor 5-[[4-[(2,3-dimethyl-2h-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methylbenzenesulfonamide, or a pharmaceutically acceptable salt thereof, with a b-raf inhibitor, particularly n-{3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which the inhibition of vegfr and/or b-raf is beneficial.. . Novartis Ag |
The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of, e.g., a metap-2 inhibitor.. . Zafgen, Inc. |
The present invention provides a process for the production of a boiled beef flavour comprising heating a composition comprising a reducing sugar and cysteine and 4-hydroxy-2,5-dimethyl-3(2h)-furanone characterized in that the composition is heated and extruded in an extruder at a temperature between 80° c. And 140° c.. Dsm Ip Assets B.v. |
Polyester composition for extrusion blow molded containers with improved aging and drop performance The present invention relates to a polyester resin for extrusion blow molded containers comprising a branched copolymer and fumed silica to improve the aged drop performance said branched copolyester is made from the reaction of purified terephthalic acid or its dimethyl ester, ethylene glycol, bifunctional diacid other than terephthalic acid, diol other than ethylene glycol, and multifunctional compound having a least 3 carboxyl groups, hydroxyl groups and/or ester forming groups thereof, said fumed silica has a particle size of 0.1 to 5 microns and is present at about 100 ppm to about 2,500 ppm based on the weight of said copolyester.. . Auriga Polymers, Inc. |
Provided herein are novel solid forms of n-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2h-pyran-4-yl)amino)-4-methyl-4′-(morpholinomethyl)-[1,1′-biphenyl]-3-carboxamide hydrochloride, and related compositions and methods.. . Eisai R&d Management Co., Ltd. |
Novel substituted n, n-dimethylaminoalkyl ethers of isoflavanone oximes as h1-receptor antagonists The present invention relates to compounds of formula (i), and salts thereof and the pharmaceutical composition containing them in treatment of various diseases, as allergic rhinitis where r1 and r2 are, independently, hydrogen, halogen, c1_3 alkyl or c1-3alkoxy; r3 is phenyl optionally substituted by r4 and r5 which are, independently hydrogen, halogen, c1-3 alkyl, c1-3-alkoxy, fluoro-, difluoro- and trifluoromethyl, nitrile group, n,n-dic1-3alkyl-amide, carboc1-3 alkoxy or c1-3alkylsulphone groups; r3 is pyridyl group containing nitrogen at various positions in the benzene ring, n is one of the integers 1 or 2.. . Polfarmex S.a. |
(b2) separating the amide of n,n-dimethylbisaminoethylether from mixture b; and (c2) recovering n,n-dimethylbisaminoethylether from its amide by means of a transamidation reaction.. . |
The present invention relates to a process for the preparation of dimethyl fumarate, a compound of formula i, in a purity of at least 99.0% as determined by hplc, containing less than 400 ppm of an anion of a mineral acid and less than 5 ppm of dimethyl maleate.. . Glenmark Pharmaceuticals Limited; Glenmark Generics Limited |
Electrospinning with reduced current or using fluid of reduced conductivity A method comprises: dissolving an aromatic side chain polymer in a terpene, terpenoid, or aromatic solvent; dissolving an inorganic salt in a polar organic solvent; mixing the salt solution and the polymer solution; and using a predominantly terpene, terpenoid, or aromatic solvent phase of the mixture as electrospinning fluid. The fluid is electrospun from spinning tip(s) onto a target substrate. Nanostatics Corporation |
Immobilized metathesis tungsten oxo alkylidene catalysts and use thereof in olefin metathesis Method of making an immobilized tungsten catalyst comprising or consisting of (≡sio)xw(═o)(═cr1r2)(r3 or r4)2-x(l)z, comprising at least the following step (i): (i) reacting silica (si02) with a tungsten oxo alkylidene complex comprising or consisting of (r3)(r4)w(═o)(═cr1r2)(l)y, preferably wherein ═cr1r2 is selected from ═chc(ch3)3 or ═ch(c(ch3)2)c6h5 and r3 and r4 are independently selected from pyrrol-1-yl, 2,5-dimethylpyrrol-1-yl, or 2,5-diphenylpyrrol-1-yl, or —or, wherein r is a six membered or 10 membered aryl ring, optionally substituted.. . Ximo Ag |
Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin d analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(s)-1α-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(s)-2-methylene-1α,25-dihydroxyvitamin d3, 2-methylene-1α,25-dihydroxy-(17e)-17(20)-dehydro-19-nor-vitamin d3, 2-methylene-19-nor-(24r)-1α,25-dihydroxyvitamin d2, 2-methylene-(20r,25s)-19,26-dinor-1α,25-dihydroxyvitamin d3, 2-methylene-19-nor-1α-hydroxy-pregnacalciferol, 1α-hydroxy-2-methylene-19-nor-homopregnacalciferol, (20r)-1α-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, 2-methylene-19-nor-(20s)-1α-hydroxy-trishomopregnacalciferol, 2-methylene-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnacalciferol, 2-methylene-(20s)-23,23-difluoro-1α-hydroxy-19-nor-bishomopregnancalciferol, (2-(3′hydroxypropyl-1′,2′-idene)-19,23,24-trinor-(20s)-1α-hydroxyvitamin d3, 2-methylene-18,19-dinor-(20s)-1α,25-dihydroxyvitamin d3, a stereoisomer thereof, a prodrug thereof in oral compositions, a salt thereof, and/or a solute thereof. Wisconsin Alumni Research Foundation |
{4-[5-(3-chloro-phenoxy)-oxazolo[5,4-d]pyrimidin-2-yl]-2,6-dimethyl-phenoxy}-acetic acid or a pharmaceutically acceptable salt thereof for use in the prevention or treatment of aki (acute kidney injury). Medicament and pharmaceutical composition thereof.. Sanofi |
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Enzalutamide in combination with afuresertib for the treatment of cancer A novel combination comprising an androgen receptor inhibitor, for example: 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide or a pharmaceutically acceptable salt thereof, and an akt inhibiting compound, for example: n-{(1s)-2-amino-1-[(3-fluorophenyl)methyl]ethyl}-5-chloro-4-(4-chloro-1-methyl-1h-pyrazol-5-yl)-2-thiophenecarboxamide, or a pharmaceutically acceptable salt thereof, and optional additional antineoplastic agents; pharmaceutical compositions comprising the same and methods of using such combinations and compositions in the treatment of conditions in which androgen receptor inhibition and/or akt inhibition is beneficial, e.g., cancer.. . Novartis Ag |
Electrolyte solution for redox flow battery and redox flow battery comprising same The provided are an electrolyte for redox flow battery and a redox flow battery comprising the same, wherein the electrolyte for redox flow battery comprises a solute and a solvent, wherein said solute comprises at least one of anode active material and cathode active material, wherein said anode active material comprises at least one of organic compounds having a carbonyl group such as benzophenone-, benzoquinone-, dimethyl terephthalate-, and 1,4-diacetylbenzene-based organic compounds, and said cathode active material comprises at least one of amine-, tetrathiafulvalene-, and n,n,n′,n′-tetramethyl-p-phenylenediamine-based organic compounds.. . Seoul National University R&db Foundation |
Iridium complexes and organic electroluminescence device using the same The present invention discloses an iridium complexes and the organic el device employing the iridium complexes as light emitting guest of emitting layer can display good performance like as lower driving voltage and power consumption, increasing efficiency and half-life time. Additional, the present invention provide the suitable emitting host (h1 to h6) to collocate with the energy level of iridium complexes for the present invention. Luminescence Technology Corporation |
Methods and materials to enhance high temperature rheology in invert emulsions An invert emulsion drilling fluid, and a method of drilling with such fluid, having improved rheology at low mud weights and high temperatures. The improved rheology is effected with addition of a rheology additive of the invention comprising fatty dimer diamines or dimer diamines and an organic acid or ester of the acid. Halliburton Energy Services, Inc. |
Floor coating compositions containing supramolecular polymers The present invention provides an aqueous floor coating composition comprising: (a) water; (b) at least one supramolecular polymer; and (c) optionally, one or more additional ingredients. The supramolecular polymer (b) comprises polymerized units derived from: (1) one or more 4h monomers which comprise a polymerizable group and a quadruple hydrogen bonding (4h) moiety; (2) at least one monomer having acid functional groups; and (3) one or more ethylenically unsaturated monomers. Rohm And Haas Company |
The invention relates to an improved process for synthesizing n,n-dicyclopropyl-4-(1,5-dimethyl-1h-pyrazol-3-ylamino)-6-ethyl-1-methyl-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridine-7-carboxamide of the formula: (i) compound (i) is currently in clinical trials for the treatment of myeloproliferative disorders, such as polycythaemia vera, thrombocythaemia and primary myelofibrosis.. . Bristol-myers Squibb Company |
An object of the present invention is to provide a compound and pharmaceutical composition showing superior stability and/or solubility, etc. And having superior flt3 inhibitory activity. Fujifilm Corporation |
The present invention relates to solid state forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1), pharmaceutical compositions thereof and methods therewith.. . Vertex Pharmaceuticals Incorporated |
Method for extraction and concentration of alkaloids using dimethyl ether The present invention is directed to a method for the extraction and/or enrichment of alkaloids from a mixture containing such compounds. More particularly, the present invention is directed to methods for extracting one or more alkaloids using dimethyl ether.. Noramco, Inc. |
Methods and compositions for using a tetracycline compound to treat bacterial infections are described. In one embodiment, for example, the invention provides a method of treating a subject for an infection, comprising administering to said subject an effective amount of 9-[(2,2-dimethyl-propyl amino)-methyl]-minocycline or a salt thereof, such that said subject is treated, wherein said infection is selected from the group consisting of mssa, mrsa, b-streptococci, viridans streptococci, enterococcus, or combinations thereof.. Paratek Pharmaceuticals, Inc. |
Therapeutic uses of compounds having combined sert, 5-ht3 and 5-ht1a activity New pharmaceutical uses of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine and pharmaceutically acceptable salts thereof are provided.. . Takeda Pharmaceuticals U.s.a., Inc. |
An anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells The present invention provides the compound ormeloxifene [3,4-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-methoxy chroman] as useful in inducing differentiation in wide range of myeloid leukemias including acute promyelocytic leukemia, acute myeloid leukemia and chronic myeloid leukemia where block in differentiation is common feature. Ormeloxifene induced differentiation that is marked by increase in differentiation marker proteins like c/ebpα and surface proteins such as cd11b and granulocyte colony stimulating factor receptor (gcsfr). Council Of Scienticfic & Industrial Research |
Present invention relates to methods for preparing (1α, 2β, 4β, 5α, 7β)-7-[(hydroxidi-2-thienllacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane-bromide.. . |
Process for the preparation of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol The present invention relates to a process for the preparation of (1r,2r)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.. . GrÜnenthal Gmbh |
Provided is an oxygen enrichment membrane that has both good oxygen separation performance and good membrane physical properties (mechanical strength, ease of membrane formation, etc.), and moreover, can be used to industrially obtain a high concentration of oxygen, and a method for producing the oxygen enrichment membrane. The oxygen enrichment membrane includes, as a main component, a hydrocarbon group-containing polysiloxane network structure material which is a reaction product of a tetraalkoxysilane and a hydrocarbon group-containing dialkoxysilane. Toyo Tire & Rubber Co., Ltd. |
Pharmaceutical compositions of growth hormone secretagogue receptor ligands The present invention relates to improvements in compositions containing peptides that are ligands of the ghs receptor, or pharmaceutically acceptable salts thereof, methods for preparing such compositions, and methods of using such compositions to treat mammals. In particular, the present invention relates to a pharmaceutical composition comprising a pamoate salt of h-inp-d-bal-d-trp-phe-apc-nh2, which is a ligand of the ghs receptor and in which, after subcutaneous or intramuscular administration to a subject, the peptide forms an in situ depot at physiological ph that is slowly dissolved and released into the body fluid and bloodstream. Ipsen Pharma S.a.s. |
Novel crystal form of an organic compound and process for the preparation thereof The present invention relates to novel crystalline form ii of 17α-acetoxy-21-methoxy-11β-[4-n,n-dimethylaminophenyl]-19-norpregna-4,9-diene-3,20-dione, (also known as cdb-4124), processes for the preparation thereof and pharmaceutical composition comprising it. Form ii can be crystallized from different medium such as esters of c1-c4 alcohols and carboxylic acids, ketones, cyclohexane, acetonitrile, dimethylformamide, dimethyl sulfoxide, water and any mixture thereof.. Richter Gedeon Nyrt. |
The present invention relates to a method of treating a glomerular disease with 6-(5-cyclopropylcarbamoyl-3-fluoro-2-methyl-phenyl)-n-(2,2-dimethylpropyl)-nicotinamide or a pharmaceutically acceptable salt thereof.. . Glaxosmithkline Intellectual Property (no.2) Limited |
The present invention relates to an abuse-proofed oral dosage form with controlled release of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (a), at least one synthetic or natural polymer (c), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (b) and optionally a wax (d), component (c) or (d) in each case exhibiting a breaking strength of at least 500 n, preferably of at least 1000 n.. . GrÜnenthal Gmbh |
A multi-part kit system comprising (i) a solid part a which comprises 10 to 80 wt. % of peroxy compound selected from the group consisting of khso5, k2s2o8, na2s2o8, magnesium monoperoxyphthalate hexahydrate, sodium percarbonate and sodium perborate, 0.1 to 10 wt. The Chemours Company Fc, Llc |
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Method and cryopreservation of blood cells in a sterile environment An apparatus and related method for the optimization of the cryopreservation of various types of cells, including but not limited to hematopoietic and mesenchymal stem and progenitor cells, and endothelial progenitor cells found in normal blood, placental/cord blood, bone marrow or the stromal vascular fraction of adipose tissue. The apparatus for cryopreservation of biological materials in a sterile environment comprises a cryopreservation workstation, a rigid disposable cartridge, and a freezing bag assembly. Syngen, Inc. |
A family of silicone rubbers (e.g., polydimethylsiloxane) carrying one or more cyanoacrylate groups and their methods of production are provided. These silicone rubbers endowed with cyanoacrylate groups are useful in a variety of wound care applications, including wound closures, adhesives, sealants and skin protectors. The University Of Akron |
A method of producing 4-(((6s,9s)-1-(benzylcarbamoyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro -1h-pyrazino[2,1-c][1,2,4]triazin-6-yl)methyl)phenyl dihydrogen phosphate, including a step of adding a reaction mixture 1 containing (6s,9s)-n-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)octahydro -1h-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide, triethylamine and a solvent to a reaction mixture 2 containing a phosphorylating agent and a solvent.. . Prism Pharma Co., Ltd. |
Disclosed are compounds that inhibit breast cancer resistance protein (bcrp), of which compound (i-1), ((3s, 6s, 12as)-6-isobutyl-9-methoxy-3-methyl-2,3,6,7, 12, 12a- hexahydropyrazino[1′,2′: 1,6]pyrido[3,4-b]indole-1,4-dione) or a pharmaceutically acceptable salt thereof, and the compound 12, ((3s,6s,12as)-6-isobutyl-9-methoxy-3,10- dimethyl-2,3,6,7,12, 12a-hexahydropyrazino[1′,2′: 1,6]pyrido[3,4- b] indole-1,4-dione) or a pharmaceutically acceptable salt thereof. Also disclosed are methods of inhibiting bcrp or decreasing bcrp activity and methods of determining potential bcrp substrates.. Millennium Pharmaceuticals, Inc. |
A method of making silicone microspheres comprises nebulizing a silicone precursor solution comprising one or more oligomeric dimethylsiloxanes, a catalyst and a solvent into an aerosol comprising a plurality of droplets. Each droplet comprises the silicone precursor solution. The Board Of Trustees Of The University Of Illinois |
An inkjet printing method includes the steps of jetting ink dots on a substrate of a plurality of radiation curable inkjet inks having a viscosity of no more than 50 mpa·s at 25° c. And a shear rate of 90 s−1, the plurality of radiation curable inkjet inks including a) at least one non-polymerizable, non-polymeric bisacylphosphine oxide present in a concentration of no more than 4.0 wt % based on the total weight of radiation curable inkjet ink; b) at least one monomer including at least one vinyl ether group and at least one polymerizable group selected from the group consisting of an acrylate group and a methacrylate group; and c) at least one polymerizable or polymeric thioxanthone, with the proviso that if the at least one polymerizable or polymeric thioxanthone contains no tertiary amine group that the radiation curable composition further includes at least one tertiary amine co-initiator selected from the group consisting of ethylhexyl-4-dimethylaminobenzoate, a polymerizable co-initiator containing a tertiary amine and a polymeric co-initiator containing a tertiary amine; and (2) fully curing the jetted ink dots using one or more uv leds.. Agfa Graphics Nv |
Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of pd, rh, and ru, together with at least a second metal from the list consisting of ag, ni, co, sn, cu and au. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of agrochemically active compounds and microbiocides of the methoximinophenylglyoxylic ester series. Taminco Bvba |
A polyester resin for use in a process in which, during an expansion step, an incompressible fluid is injected through an opening of a preform, formed of the polyester resin, to form a container. The polyester resin includes a crystallizable polyester polymer wherein the polyester polymer is comprised of acid moieties and glycol moieties, with at least 85% of the total moles of acid moieties being terephthalate derived from terephthalic acid or its dimethyl ester and at least 85% of the total moles of glycol moieties derived from ethylene glycol. Discma Ag |
Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose The present invention relates to pharmaceutical compositions containing dimethyl fumarate (dmf), more specifically, the present invention relates to a pharmaceutical composition for oral use in treating hyperproliferative, inflammatory or autoimmune disorders by administering a low daily dosage in the range of 410 mg±5% or 400 mg±5% dimethyl fumarate, wherein the pharmaceutical formulation is in the form of an erosion matrix tablet.. . Forward Pharma A/s |
Pharmaceutical composition containing dimethyl fumarate for administration at a low daily dose The present invention relates to pharmaceutical compositions containing dimethyl fumarate (dmf). More specifically, the present invention relates to a pharmaceutical composition for oral use in treating psoriasis by administering a low daily dosage in the range of 375 mg±5% dimethyl fumarate, wherein the pharmaceutical formulation is in the form of an erosion matrix tablet.. Forward Pharma A/s |
The invention relates to a capacitive micro-machined ultrasound transducer (cmut) cell (6) comprising a cell floor (31) having a first electrode (7); a cell membrane (5) having a second electrode (7′) which opposes the first electrode and vibrates during transmission or reception of acoustic energy; a transmitter/receiver coupled to the first and second electrodes which causes the cell membrane to vibrate at an acoustic frequency and/or receives signals at an acoustic frequency; and an acoustic lens (13), overlaying the cell membrane, and having an inner surface opposing the cell membrane and an outer, patient-facing surface. According to the present invention the acoustic lens comprises at least one layer of a material selected from the group of: polybudatiene, polyether block amide (pebax), polydimethylsiloxane (pdms) and buthylrubber.. Koninklijke Philips N.v. |
A cellulose reactive glyoxalated copolymer composition and methods of producing and using the glyoxalated copolymer composition to, for instance, strengthen paper or board are discussed. A glyoxalated copolymer composition includes an aqueous medium containing a glyoxalated copolymer, wherein the glyoxalated copolymer is obtained by reaction in an aqueous reaction medium of a dry weight ratio of glyoxalxationic copolymer. Basf Se |
A radiation curable inkjet ink set includes at least a cyan radiation curable inkjet ink, a magenta radiation curable inkjet ink, a yellow radiation curable inkjet ink, and a black radiation curable inkjet ink, each having a viscosity of no more than 50 mpa·s at 25° c. And a shear rate of 90 s-1 and containing: a) at least one non-polymerizable, non-polymeric bisacylphosphine oxide present in a concentration of no more than 4.0 wt % based on the total weight of the radiation curable composition; b) at least one monomer including at least one vinyl ether group and at least one polymerizable group selected from the group consisting of an acrylate group and a methacrylate group; and c) at least one polymerizable or polymeric thioxanthone, with the proviso that if the at least one polymerizable or polymeric thioxanthone contains no tertiary amine group that the radiation curable composition further includes at least one tertiary amine co-initiator selected from the group consisting of ethylhexyl-4-dimethylaminobenzoate, a polymerizable co-initiator containing a tertiary amine and a polymeric co-initiator containing a tertiary amine.. Agfa Graphics Nv |
A radiation curable inkjet ink set containing a plurality of inkjet inks having a viscosity of no more than 50 mpa·s at 25° c. And a shear rate of 90 s-1, each of the inkjet inks including a) at least one non-polymerizable, non-polymeric bisacylphosphine oxide present in a concentration of no more than 4.0 wt % based on the total weight of the inkjet ink; b) at least one monomer including at least one vinyl ether group and at least one polymerizable group selected from the group consisting of an acrylate group and a methacrylate group; and c) at least one polymerizable or polymeric thioxanthone, with the proviso that if the at least one polymerizable or polymeric thioxanthone contains no tertiary amine group, then the inkjet ink further includes at least one tertiary amine co-initiator selected from the group consisting of ethylhexyl-4-dimethylaminobenzoate and a polymerizable co-initiator containing a tertiary amine.. Agfa Graphics Nv |
Provided herein are methods of producing dialkylfurans, such as 2,5-dimethylfuran, and other alkyl furans, such as 2-methylfuran. For example, 2,5-dimethylfuran may be produced by reducing (5-methylfuran-2-yl)methanol or 2-(chloromethyl)-5-methylfuran.. Micromidas, Inc. |
This invention relates to an improved one-pot synthetic process for the preparation of glycidol from the reaction of glycerol and dimethyl carbonate. More specifically, the invention relates to a one-pot synthetic process for the preparation of glycidol comprising the reaction of glycerol and dimethyl carbonate in the presence of an ionic liquid catalyst having the formula: [cat+][x] wherein: [cat] represents one or more cationic species, and [x] represents one or more anionic species; wherein the reaction is conducted at a temperature of from 100° c. |
Reducing the compound represented by formula (3) or the salt thereof to obtain the compound represented by formula (1) or the salt thereof.. . |
A crystalline mono hydrochloride salt of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide is disclosed having improved stability. In addition, a crystalline mono mesylate salt and crystalline mono sulfate salt of (4s,4as,5ar,12as)-4-dimethylamino-3,10,12,12a-tetrahydroxy-7-[(methoxy(methyl)amino)-methyl]-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydro-naphthacene-2-carboxylic acid amide are also disclosed having improved stability. Paratek Pharmaceuticals, Inc. |
Disclosed are novel pharmaceutical compositions containing 3′-[(2z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4h-pyrazol-4-ylidene]hydrazinol-2′-hydroxy-[1,1′-biphenyl]-3-carboxylic acid bis-(monoethanolamine) (eltrombopag olamine) and processes for preparing the same.. . Novartis Ag |
The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient, which is selected from (1r,4r)-6′-fluoro-n,n-dimethyl-4-phenyl-4′,9′-dihydro-3′h-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient, which is a propionic acid derivative selected from the group consisting of ibuprofen, naproxen, ketoprofen, flurbiprofen, fenoprofen, fenbufen, suprofen, pirprofen, indoprofen, tiaprofenic acid, oxaprozin, ibuproxam, flunoxaprofen, alminoprofen, naproxcinod, and the physiologically acceptable salts thereof.. . Gruenenthal Gmbh |
A synergistic antimicrobial composition having two components. The first component is a hydroxymethyl-substituted phosphorus compound. Dow Global Technologies Llc |
The current invention provides a kit of parts for producing an emulsifiable pesticide solution comprising: (a) a water miscible organic solvent selected from the list of a glycol ether, a glycerol formal, dimethylsulfoxide, gamma-butyrolactone or mixtures thereof, (b) an alkoxylated alcohol with an average of 6 to 80 moles of ethylene oxide and 2 to 60 moles of propylene oxide per mole of alcohol; and (c) a pesticidal active ingredient. The invention further provides a composition for producing an emulsifiable pesticide solution, a method for producing such a composition and a method for treating an agricultural crop. Arysta Lifescience Benelux Sprl |
Composition comprising polymeric organic semiconducting compounds The present invention relates to novel compositions comprising one or more polymeric organic semiconducting (osc) compounds and one or more organic solvents. The composition preferably comprises 3,4-dimethyl anisole as solvent. Merck Patent Gmbh |
A stabilizer composition having low volatility and high efficiency comprising: (i.) 25.000% to 99.997% by weight of at least one dimethyltin compound of formula (ch3)2sn(s(ch2)mcoor1)2 wherein r1 is a linear, branched or cyclic c10-c20 alkyl group and m is 1 or 2, optionally containing unsaturations in the form of double or triple bonds; (ii.) 0.001% to 50.000% by weight of at least one mono-methyltin compound of formula ch3sn(s(ch2)ncoor2)3 wherein r2 is a linear, branched or cyclic c10-c20 alkyl group and n is 1 or 2, optionally containing unsaturations in the form of double or triple bonds; (iii.) 0.001% to 10.000% by weight of at least one tri-methyltin compound of formula (ch3)3sn(s(ch2)pcoor3) wherein r3 is a linear, branched or cyclic c10-c20 alkyl group and p is 1 or 2, optionally containing unsaturations in the form of double or triple bonds; and (iv.) 0.001% to 15.000% by weight of at least one thioester of formula hs(ch2)qcoor4 wherein r4 is a linear, branched or cyclic c10-c20 alkyl group and q is 1 or 2, optionally containing unsaturations in the form of double or triple bonds.. . Galata Chemicals Llc |
Polydimethylsiloxane sheet, optical element incorporating the same, and manufacturing method thereof A method of manufacturing a pdms sheet that ensures good adhesion, handleability and stability to metal thin films or metal patterns of any desired shape. Given a low-molecular-weight siloxane of a cyclic structure represented by [—si(ch3)2o—]k where k is an integer of 3 to 20 inclusive, the polydimethylsiloxane sheet has a structure where the content of the low-molecular-weight siloxane at the pattern-formation surface is more than that of the low-molecular-weight siloxane at the base surface, and a spacing between the adjacent metal patterns is variable by deformation of the polydimethylsiloxane sheet.. Dai Nippon Printing Co., Ltd. |
Gold(i) complexes with t-butyl phosphine and dialkyl dithiocarbamate ligands Gold(i) complexes of formulae [au{p(t-bu)3}(s2cn(ch3)2)] (1), and [au{p(t-bu)3}(s2cn(c2h5)2)] (2) have been prepared by the reaction of equimolar amounts of [au{p(t-bu)3}(cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry. King Abdulaziz City For Science And Technology |
The invention relates to a pharmaceutical composition comprising a first pharmacologically active ingredient selected from (1r,4r)-6′-fluoro-n,n-dimethyl-4-phenyl-4′,9′-dihydro-3′h-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and the physiologically acceptable salts thereof, and a second pharmacologically active ingredient selected from gabapentinoids and the physiologically acceptable salts thereof.. . Gruenenthal Gmbh |
The disclosure is directed to methods and apparatus for the determination, diagnosis, progression and prognosis of kidney disease and mortality associated with kidney disease. The disclosure includes methods for determining renal function, in particular estimating glomerular filtration rate (gfr), in an animal. |
Described are alkenol dehydratase variants having improved activity in catalyzing the conversion of a compound corresponding to the general formula cnh2no into cnh2n-2+h2o with 3<n<7. In particular, described are alkenol dehydratase variants having, e.g., an improved activity in converting but-2-en-1-ol (crotyl alcohol) into 1,3 butadiene and/or an improved activity in converting but-3-en-2-ol into 1,3 butadiene and/or an improved activity in converting 3-methylbut-2-en-1-ol (prenol) or 3-methylbut-3-en-2-ol (isoprenol) into isoprene and/or an improved activity in converting 2,3-dimethyl-but-2-en-1-ol into dimethyl-butadiene.. |
A process is provided for recovering oil from a hydrocarbon-bearing formation comprised of hydrocarbons and formation water. The process presented herein includes an oil recovery formulation comprising at least 75 mol % dimethyl sulfide and between 1 mol % and 18 mol % of dimethyl ether, wherein the amount of dimethyl ether in the oil recovery formulation is selected relative to the solubility of dimethyl ether in the formation water.. |
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