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Dimethyl patents

This page is updated frequently with new Dimethyl-related patent applications. Subscribe to the Dimethyl RSS feed to automatically get the update: related Dimethyl RSS feeds. RSS updates for this page: Dimethyl RSS RSS

Date/App# patent app List of recent Dimethyl-related patents
 Branched  alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses patent thumbnailBranched alpha-glucan, alpha-glucosyltransferase which forms the glucan, their preparation and uses
(4) content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.. .

 Liquid detergent composition patent thumbnailLiquid detergent composition
B) a cationic unit derived from a dimethyldiallylammonium salt.. .

 Silicone formulation with improved storage stability patent thumbnailSilicone formulation with improved storage stability
A one-component or two-component silicone formulation including: a) at least one cross-linkable poly(diorganosiloxane); b) at least one oligomeric siloxane as a cross-linker for the poly(diorganosiloxane), wherein the oligomeric siloxane is a condensation product of monomeric silane cross-linkers; and c) at least one functionalized oligo(dimethylsiloxane). The one-component or two-component silicone formulation is suitable as an elastic adhesive or sealant, for example, in the automotive and solar fields, for façade construction, insulation glass, window glass or for construction in general..
Sika Technology Ag

 Gold(i) complexes with t-butyl phosphine and dialkyl dithiocarbamate ligands patent thumbnailGold(i) complexes with t-butyl phosphine and dialkyl dithiocarbamate ligands
Gold(i) complexes of formulae [au{p(t-bu)3}(s2cn(ch3)2)] (1), and [au{p(t-bu)3}(s2cn(c2h5)2)] (2) have been prepared by the reaction of equimolar amounts of [au{p(t-bu)3}(cl)] with sodium dimethyldithiocarbamate monohydrate, and sodium diethyldithiocarbamate trihydrate respectively. Both complexes (1) and (2) are iso-structural having linear geometry.
King Fahd University Of Petroleum And Minerals

 Production  thienopyrimidine derivative patent thumbnailProduction thienopyrimidine derivative
The present invention provides a production method of a thienopyrimidine derivative or a salt thereof which has a gonadotropin releasing hormone (gnrh) antagonistic action with high quality in high yield. The present invention provides a method of producing a thienopyrimidine derivative, which comprises reacting 6-(4-aminophenyl)-1-(2,6-difluorobenzyl)-5-dimethyl aminomethyl-3-(6-methoxypyridazin-3-yl)thieno[2,3-d]pyrimidine-2,4(1h,3h)-dione or salt thereof, 1,1′-carbonyldiimidazole or a salt thereof and methoxyamine or a salt thereof, and the like..
Takeda Pharmaceutical Company Limited

 Novel crystalline form of vortioxetine hydrobromide patent thumbnailNovel crystalline form of vortioxetine hydrobromide
The present invention is directed to a crystalline compound comprising a hydrobromide acid (hbr) salt of a compound of formula (i) (1-{2[2,4-dimethylphenyl)sulfanyl]phenyl}piperazine, inn: vortioxetine), having an xrpd pattern with characteristic peaks (expressed in 2θ±0.2° 2θ (cukα radiation)) at 5.5°, 14.8°, 16.7° and 20.0° and processes for obtaining the same.. .
Sandoz Ag

 Methods of producing para-xylene and terephthalic acid patent thumbnailMethods of producing para-xylene and terephthalic acid
The present disclosure provides methods to produce para-xylene, toluene, and other compounds from renewable sources (e.g., cellulose, hemicellulose, starch, sugar) and ethylene in the presence of a catalyst. For example, cellulose and/or hemicellulose may be converted into 2,5-dimethylfuran (dmf), which may be converted into para-xylene by cycloaddition of ethylene to dmf.
Micromidas, Inc.

 Therapeutic peptide compositions and methods patent thumbnailTherapeutic peptide compositions and methods
Therapeutic peptide compositions comprise a therapeutic peptide, such as insulin, together with an alkyl n,n-disubstituted amino acetate, such as dodecyl 2-(n,n-dimethylamino)propionate.. .
Nexmed Holdings, Inc.

 Rhodobacter for preparing terpenoids patent thumbnailRhodobacter for preparing terpenoids
The invention relates to a rhodobacter host cell, comprising a nucleic acid encoding—enzymes of a mevalonate pathway for making isoprenyl pyrophosphate (ipp) and its isomer dimethylallyl pyrophosphate (dmapp);—an enzyme having catalytic activity for the condensation of ipp and dmapp into geranyl diphosphate (gpp) and—an enzyme having monoterpene synthase activity in the conversion of gpp into a monoterpene or sesquiterpene synthase activity.. .
Isobionics B.v.

 High impact strength polymers patent thumbnailHigh impact strength polymers
In an embodiment, a copolymer is formed from a monomer composition that includes a 2,2,4,4-tetraalkyl-1,3-cyclobutanediol monomer; one or more aromatic dicarboxylic acids, aromatic dicarboxylic diesters, and/or aromatic dicarboxylic anhydride; 1,3-propanediol or 1,4-butanediol; and 2,2-dimethyl-1,3-propanediol. In some embodiments, a copolymer is formed from a monomer composition that includes a 2,2,4,4-tetraalkyl-1,3-cyclobutanediol monomer, wherein at least 90% of the 2,2,4,4-tetraalkyl-1,3-cyclobutanediol monomer is in the cis- or trans-form..
Texas State University-san Marcos


Refractory castables with hydrophobic aggregates

Hydrophobic aggregates for use in refractory castables and gunning mixtures and methods of their preparation. The aggregates here are formed by crushing insulating fire brick and coating the resulting particles with a hydrophobic component.
Bnz Materials, Inc.


Synergistic microbicidal combinations

Antimicrobial compositions based on the synergistic combination of 2-methyl-3-isothiazolone and selected commercial microbicides where the compositions are substantially free of halogenated 3-isothiazolone, are disclosed. Particularly preferred are combinations of 2-methyl-3-isothiazolone together with benzoic acid, citric acid, sorbic acid, 1,2-dibromo-2,4-dicyanobutane, 1,3-dimethylol-5,5-dimethylhydantoin, phenoxyethanol, benzyl alcohol, zinc pyrithione or climbazole, that provide enhanced microbicidal efficacy at a combined active ingredient level lower than that of the combined individual 3-isothiazolone and commercial microbicide effective use levels..
Rohm And Haas Company


Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using same

The present disclosure generally relates to nanoparticles comprising a substantially hydrophobic acid and a therapeutic agent (1-(4-{[4-(dimethylamino)piperidin-1-yl]carbonyl}phenyl)-3-[4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)phenyl]urea), or pharmaceutically acceptable salts thereof, and a polymer. Other aspects include methods of making and using such nanoparticles..
Bind Therapeutics, Inc.


Compounds for enhancing hypoxia inducible factor activity and methods of use

The present invention relates to methods for enhancing hypoxia inducible factor-1 (hif) activity in a cell by contacting the cell with any one of the following compounds: 3,6-bis[2-(dimethylamino)ethoxy]-9h-xanthen-9-onedihydrochloride, 2,8-bis[dimethylaminoacetyl]dibenzofurin dihydrochloride hydrate, tilorone analogue r-9536-da, indoprofen, ciclopiroxolamine, tryptophan, ansindione, nabumetone, oxybendazole, albendazole, tropicamide, pramoxine hydrochloride, atenolol, mebendazole, carbetapentane citrate, monensin sodium, methoxyvone, hydroxyzine, phenazopyridine, clofoctol, ipraflavone, zomepirac, biochanin a, xylometazoline hydrochloride, fenbendazole, pirenzepine, triprolidine hydrochloride, daidzein, tripelennamine citrate, colchicines, aminopyridine, trimethoprim, helenine, hydroxyurea, amiodarone hydrochloride, clindamycin hydrochloride, sulfachlorpyridazine, mephenesin, semustine, clofivric acid, clofibrate, ibuprofen, hyoscyamime, nafcillin sodium, piperin, clidinium bromide, trioxsalen, hydralazine and hif alpha protein fused to a carrier peptide.. .
Cornell Research Foundation, Inc.


Organometallic precursors and methods of forming thin layers using the same

An organometallic precursor is represented by a chemical formula of xn(m)(r1)m(r2)k. M is a central metal.
Samsung Electronics Co., Ltd.


Solid marine seismic streamers

A marine seismic streamer comprising a solid, hydrophobic core member that is encased in a hydrophobic streamer skin/casing. The hydrophobic streamer skin may be extruded onto and/or heat welded to the hydrophobic core member.
Westerngeco L.l.c.


Method of enhancing cell growth using alkyl-amine-n-oxide (aanox)

The present invention relates to a method to enhance cell growth in culture comprising adding an alkyl-amine-n-oxide (aanox), such as dodecyldimethylamine oxide (ddao), into the culture medium in an amount sufficient to improve cell growth.. .
Baxalta Gmbh


Pavement marking compositions

A composition comprises a blend comprising (a) a binder comprising (i) c5 hydrocarbon resin or (ii) a resin comprising rosin acids, rosin esters, modified rosin acids, modified rosin esters or mixtures thereof, and (b) polydimethylsiloxane polyamide copolymer.. .
3m Innovative Properties Company


Preparation polycyclohexylenedimethylene terephthalate resin having excellent color, and polycyclohexylenedimethylene terephthalate resin prepared by the same

A preparation method of a polycyclohexylenedimethylene terephthalate resin according to the present invention includes the steps of injecting a titanium compound and a germanium compound as catalysts to a mixture of a diol compound and dicarboxylic acid under stirring and performing esterification reaction and polycondensation reaction, in which the titanium compound is injected in a titanium atom content of 20 ppm or less, based on the weight of the final polycyclohexylenedimethylene terephthalate resin. The preparation method of the polycyclohexylenedimethylene terephthalate resin according to the present invention can be used to prepare a polycyclohexylenedimethylene terephthalate resin that has excellent degree of polymerization, color and light reflectance and has remarkably improved heat stability, and it is suitable to use the polycyclohexylenedimethylene terephthalate resin according to the present invention as an led housing material..
Sk Chemicals Co., Ltd.


Viscoelastic polyurethane foam

The subject disclosure provides a viscoelastic polyurethane foam and a method of forming the viscoelastic polyurethane foam. The viscoelastic polyurethane foam comprises the reaction product of a toluene diisocyanate and an isocyanate reactive component.
Basf Se


Process for pralatrexate

The present invention provides a novel process for the purification of alpha-propargylhomoterephthalic acid dimethyl ester substantially free of homoterephthalic acid dimethyl ester. The present invention also provides a novel process for the purification of pralatrexate..
Hetero Research Foundation


Compositions for rapidly treating severe hypoglycemia

Disclosed is a composition for parenteral administration comprising a glucagon peptide which has been dried in a non-volatile glycine buffer, and wherein the glucagon peptide has a ph memory that is about equal to the ph of the glucagon peptide in the non-volatile buffer, wherein the ph memory is between 2.5 to 3.5, an aprotic polar solvent, wherein the peptide is solubilized in the aprotic polar solvent, and wherein the aprotic polar solvent is dimethyl sulfoxide (dmso), trehalose, glycine, and optionally hydrochloric acid, wherein the moisture content of the composition is less than 5 wt. %..
Xeris Pharmaceuticals, Inc.


Pharmaceutical compositions comprising 4-[1-(2,3-dimethylphenyl)ethyl]-3himidazole derivatives for treating retinal diseases

The present invention relates to pharmaceutical compositions, containing 4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole, (s) 4-[1-(2,3-dimethylphenyl)ethyl]-1h-imidazole or (s) [3-(1-(1h-imidazol-4-yl)ethyl)-2-methylphenyl]methanol, their use as pharmaceuticals for the treatment of retinal diseases, for retinal neuroprotection and vision enhancement.. .
Allergan, Inc.


Oral drug delivery formulations

In an aspect, a formulation is provided that comprises at least one active substance and at least one coat comprising eudragit e (dimethylaminoethyl methacrylate copolymer), wherein the formulation is free of any active substance external to the coat. The formulation is effective in preventing significant dose dumping in alcoholic/non-alcoholic beverage(s).


Synergistic microbicidal combinations

Antimicrobial compositions based on the synergistic combination of 2-methyl-3-isothiazolone and selected commercial microbicides where the compositions are substantially free of halogenated 3-isothiazolone, are disclosed. Particularly preferred are combinations of 2-methyl-3-isothiazolone together with benzoic acid, citric acid, sorbic acid, 1,2-dibromo-2,4-dicyanobutane, 1,3-dimethylol-5,5-dimethylhydantoin, phenoxyethanol, benzyl alcohol, zinc pyrithione or climbazole, that provide enhanced microbicidal efficacy at a combined active ingredient level lower than that of the combined individual 3-isothiazolone and commercial microbicide effective use levels..
Rohm And Haas Company


Process for producing renewable jet fuel compositions

The present invention provides a process for producing jet fuel components from syngas. Syngas is converted to methanol and ethanol, and, optionally, higher alcohols.


Catalyst capable of forming 2,5-dimethylhexenes

A process of making a catalyst and the catalyst composition made by that process comprising a multinuclear metal compound of the formula ma(pcy3)b(h)c(co)d(or)e(h2o)f with molar ratios a:b:c:d:e:f, wherein a is in the range from 2 to 2000, b is in the range from 0 to 4000, c is in the range from 0 to 6000 and d is in the range from 0 to 2000, e is in the range from 1 to 2000, and f is in the range from 0 to 100; wherein pcy3 indicates tricyclohexylphosphine, h indicates hydride, r is an alkyl group determined by the alcohol utilized and h2o is water from the reaction; and a is at least twice w. A method of making one or more 2,5-dimethylhexenes is described.
Uop Llc


Process for preparing roflumilast

The invention relates to a process for the preparation of roflumilast by reaction of an activated form of 3-(cyclopropylmethoxy)-4-(difluoromethoxy)-benzoic acid with an activating agent selected from (a) carbonyldiimidazole (cdi), (b) 1,1′-carbonyl-di-(1,2,4-triazol) (cdt), (c) 1,1′-carbonyl-bis-(2-methylimidazol), (d), 1′-carbonyl-dipyperidin, (e) n,n′-dicyclohexylcarbodiimide (dcc), (f) n,n′-diisopropylcarbodiimide (dic), (g) 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (edc) and a combination of one of the previous (a)-(g) with (h) n-hydroxysuccinimide or (i) n-hydroxyphthalimide, and the subsequent reaction with 3,5-dichloropyridine-4-amine in the presence of an inorganic base. The invention also relates to the synthesis intermediates..
Interquim, S.a.


Pharmaceutical composition and administrations thereof

The present invention relates to pharmaceutical compositions containing a solid dispersion of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide including formulations of the solid dispersions into powders, granules and mini-tablets, methods for manufacturing and processing the powders, granules and mini-tablets, and methods for treating cystic fibrosis employing the pharmaceutical composition.. .
Vertex Pharmaceuticals Incorporated


Nail polish drying method and product therefor

The invention comprises a nail drying aerosol spray that comprises a combination of solvents having different rates of volatility. One of the solvents is dimethyl ether..
32 Degrees Limited


Method for forming pattern

The invention provides a process and an apparatus for producing a high quality electronic component by reducing sagging at pattern side walls, which may occur when patterns of a wiring, an electrode, etc. Are printed by a screen printing process using an electroconductive paste, an insulation paste, or a semiconductor paste, and reducing a mesh mark on the patterns of a wiring, an electrode, etc., or a full solid surface film, as well as a pattern formation process, by which screen printing can be applied and double face printing can be conducted with the number of process steps less than a conventional process.
National Institute Of Advanced Industrial Science And Technology


Polydimethylsiloxane (pdms) based composite and synthesis method thereof

A pdms-based composite and a synthesis method thereof are disclosed. The pdms-based composite comprises a pdms gel and a plurality of conducting particles distributed within the pdms gel.
Nano And Advanced Materials Institute Limited


Pile fabric and manufacturing the same

The present invention relates to a pile fabric including an acrylic synthetic fiber at a napped portion, the acrylic synthetic fiber is obtained by spinning a spinning solution including 90 to 99 parts by weight of a polymer a and 1 to 10 parts by weight of a polymer b. The polymer a is a polymer obtained by polymerizing a composition a including 40 to 97 wt % of acrylonitrile, 0 to 5 wt % of a sulfonic acid-containing monomer and 3 to 60 wt % of another copolymerizable monomer.
Kaneka Corporation


Repellent coating composition and coating, making and uses thereof

(ii.d) the polydimethylsiloxane moiety has a molecular weight of more than 1600 g/mol.. .



The present invention relates to polyester that can be obtained by polymerization of a) terephtalacid dimethylester, and b) ethylene glycol, and c) 1,2-propylene glycol, and d) one or a plurality of polyethylene glycols having weight average molecular weights in the range of 1,000 to 2,000 g/mol, and e) one methyl polyethylene glycol having a weight average molecular weight in the range of 1,050 to 1,350 g/mol, f) either when a plurality of compounds having a reticulating effect and 3 to 6 functions that are enabled for polycondensation are present or absent. The polyester according to the invention can be used in an advantageous manner, e.g.
Clariant Finance (bvi) Limited


Process for the preparation of (1s,4s,5s)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one

Which is a key intermediate in the synthesis of edoxaban, a compound that exhibits on inhibitory effect on activated blood coagulation factor x (also referred to as activated factor x or fxa), and is useful as a preventive and/or therapeutic drug for thrombotic diseases. The process includes reacting (1s)-cyclohex-3-ene-1-carboxylic acid of formula (ii) with a brominating agent selected from the group consisting of n-bromosuccinimide or 1,3-dibromo-5, 5-dimethylhydantoin in the presence of a base selected from calcium oxide or calcium hydroxide in a solvent selected from the group comprising of dicholoromethane, toluene, tetrahydrofuran, ethyl acetate, hexanes, cyclopentyl methyl ether (cpme) or a misture thereof to get (1s, 4s 5s)-4-bromo-6-oxabicyclo[3.2.1]octan-y-one of formula (1).


Method for preparation of 2-(2,3-dimethylphenyl)-1-propanal with chloroacetone

The invention discloses a method for the preparation of 2-(2,3-dimethylphenyl)-1-propanal starting from 1-bromo 2,3-dimethylbenzene and chloroacetone, its use in perfumes and its use for the preparation of medetomidine.. .
Lonza Ltd


Process for production of dme from crude methanol

The invention provides a process for the production of purified dimethylether (dme). Methanol is dehydrated to provide a first dme-containing product.
Haldor Topsøe A/s


Method of production of the stable selenium-comprising pharmaceutical composition with a high selenium level

The present disclosure relates to the new method of producing of the stable selenium-comprising pharmaceutical compositions with a high selenium level based on the mixing of nitric acid with therapeutically effective amounts of at least two active ingredients selected from the groups consisting of 2,2-dichlorocarboxylic acids, selenium-containing compound. As a selenium-containing compound the aqueous solution of selenious acid in the amount of no more than 20%, preferably 0.5-10.0%, is used.
Obschestvos S. Ogranitchennoi Otvetstvennostju "oxygon"


Dimethylarginine dimethylaminohydrolase inhibitors and methods of use thereof

The present disclosure provides ddah modulators. Thus, the present disclosure provides a method of treating a patient suffering from a disorder characterized by excessive no production and/or elevated ddah activity, the method comprising administering to said patient an effective amount of a compound of one of formulae i-x.
The Board Of Trustees Of The Leland Stanford Junior University


Ester gels, methods of manufacture, and uses thereof

Gels of isopropyl esters of fatty alcohols that include a dimethyl/methylhydrogensiloxane copolymer, a silanol-terminated pdms or an ethenyl-terminated pdms, and a hydride functional siloxane. Also provided are methods for making the gels and articles containing them..
Jeen International Corporation


Polyurethane casting compound for producing wear protection coatings in casting house applications

The present invention relates to multi-component compositions including an isocyanate component and an amine component, wherein the isocyanate component includes a prepolymer, obtainable from toluene isocyanate and a polytetramethylene polyol, and the amine component includes a dialkylthio aryl diamine and possibly a polytetramethylene oxide polyamine. Corresponding compositions can be advantageously used as flowable or spreadable resin systems for producing surface protection coatings in casting house applications and are characterized by a significantly improved resistance to abrasion in comparison with conventional casting resin systems based on hexamethylene diisocyanate and dimethyl thiotoluene diamine..
Sika Technology Ag


Method for producing dimethyl ether and device suitable therefor

The present disclosure relates to a method and apparatus for producing dimethyl ether by catalytic dehydration of methanol and by distillation of the dehydration product. The method is characterized in that the catalytic dehydration takes place in at least two reaction stages which are connected in series and of which at least the first reaction stage is operated adiabatically, wherein a cooling of the reaction products takes place at least between the first and the second reaction stages..
Thyssenkrupp Industrial Solutions Ag


Process for the preparation of dimethyl ether

Process for the preparation of dimethyl ether product by catalytic conversion of synthesis gas to dimethyl ether comprising the steps of contacting a stream of synthesis gas comprising carbon dioxide in a dimethyl ether synthesis step in one or more reactors and with one or more catalysts active in the formation of methanol and dehydration of methanol to dimethyl ether and forming a product mixture comprising dimethyl ether, carbon dioxide and unconverted synthesis gas; cooling and separating the product mixture into a first liquid phase comprising dimethyl ether and carbon dioxide being dissolved in the formed dimethyl ether, and into a first gaseous phase comprising unconverted synthesis gas containing carbon monoxide and carbon dioxide; passing the first liquid phase to a scrubbing zone and contacting the phase with a liquid sorbent being effective in absorption of carbon dioxide; and withdrawing a dimethyl ether product being depleted in carbon dioxide from the scrubbing zone.. .
Haldor Topsoe A/s


Multivalent pneumococcal polysaccharide-protein conjugate composition

An immunogenic composition having 13 distinct polysaccharide-protein conjugates and optionally, an aluminum-based adjuvant, is described. Each conjugate contains a capsular polysaccharide prepared from a different serotype of streptococcus pneumoniae (1, 3, 4, 5, 6a, 6b, 7f, 9v, 14, 18c, 19a, 19f and 23f) conjugated to a carrier protein.
Wyeth Llc


Organoarsenic compounds and methods for the treatment of cancer

A method for treating a lymphoma selected from non-hodgkin's and hodgkin's lymphoma comprising administering an organoarsenic compound having a structure of the formula (i) wherein x is s or se and r1 and r2 are independently c1-30alkyl (r3, r3′, r4, r5, w and “n” are as defined in claim 1) in particular where the compound is s-dimethylarsinoglutathione, n-(2-s-dimethylarsinothiopropionyl)glycine, 2-amino-3-(dimethylarsino)thio-3-methylbutanoic acid, s-dimethylarsino-thiosuccinic acid or s-dipropylarsino-1-thioglycerol.. .


Chromane compounds

The present invention provides a hydrate of n-[(4s)-2-amino-2′,2′-dimethyldispiro[1,3-oxazole-4,4′-chromene-3′,3″-oxetan]-6′-yl]-5-chloropyridine-2-carboxamide which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by β-secretase activity, hydrolysis of a β-secretase site of a β-amyloid precursor protein, and/or β-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, glaucoma, mci (mild cognitive impairment) or alzheimer's disease, especially, alzheimer's disease.. .
Comentis, Inc.


Lithium secondary battery and producing same

This invention provides a lithium secondary battery comprising a positive electrode, a negative electrode, and a non-aqueous electrolyte. On the negative electrode surface, there is present a cyclic siloxane and/or a reaction product thereof.
Toyota Jidosha Kabushiki Kaisha


Use of polyesters in washing and cleaning agents

The present invention relates to the use in washing and cleaning agents of one or a plurality of polyesters which can be obtained by polymerisation of a) terephthalic acid dimethyl ester, and b) ethylene glycol, and c) 1,2-propylene glycol, and d) one or a plurality of polyethylene glycols with mass-average molecular weights in the range from 1000 to 2000 g/mol, and e) a methyl polyethylene glycol with a mass-average molecular weight in the range from 1050 to 1350 g/mol, f) either in the presence of or in the absence of one or a plurality of cross-linking compounds with 3 to 6 polycondensation-capable functions. The polyesters are particularly suited for use in the washing and cleaning agents as dispersants or as soil release polymers..
Clariant Finance (bvi) Limited


Strong base amines to minimize corrosion in systems prone to form corrosive salts

Corrosion by ammonia/amine salts in hydrocarbon streams such as distillation overhead streams that contain a mineral acid and water can be prevented, avoided or minimized by adding certain strong amines to the streams. The amines have a pka between about 10.5 to about 12 and include, but are not necessarily limited to, dimethylamine, diethylamine, dipropylamine, diisopropylamine, di-n-butylamine, diisobutylamine, di-sec-butylamine, di-tert-butylamine, pyrrolidine, piperidine, and combinations thereof.
Baker Hughes Incorporated


Aggrecanase inhibitors

The present invention provides compounds having the formula: wherein r1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.. .
Eli Lily And Company


Method for producing 1-substituted-3-fluoroalkylpyrazole-4-carboxylic acid ester

The present invention is a method for producing a 1-substituted-3-fluoroalkylpyrazole-4-caroxylic acid ester, the method comprising a step of adding, to a first reaction liquid containing an alkyl hydrazine and a first organic solvent, a second reaction liquid containing an acyl acetic acid ester derivative and a second organic solvent in 0.5 to 30 hours to react the first reaction liquid with the second reaction liquid at a reaction temperature of −5 to 80° c. Under stirring in the absence of a base and an acid, wherein the first organic solvent and the second organic solvent are each at least any one of benzene, toluene, xylene, chlorobenzene, dichlorobenzene, ethyl acetate, butyl acetate, and dimethyl carbonate, a total mass of the first organic solvent and the second organic solvent is 1 to 60 times a mass of the acyl acetic acid ester derivative, and an amount of the first organic solvent in a total amount of the first organic solvent and the second organic solvent is 40 to 95% by mass..
Tama Kagaku Kogyo Co., Ltd


Stable pharmaceutical composition, comprising an aqueous solution of an antibody-derived therapeutically active protein

A storage-stable pharmaceutical composition includes an aqueous solution of at least an antibody-derived therapeutically active protein chosen amongst antibody, nanobody or fusion protein and an amount effective to stabilize the antibody-derived therapeutically active protein of at least one lauryldimethylamineoxide and/or of one of its amine oxide analogs.. .


Abuse-proofed oral dosage form

The present invention relates to an abuse-proofed oral dosage form with controlled release of (1r,2r)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (a), at least one synthetic or natural polymer (c), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (b) and optionally a wax (d), component (c) or (d) in each case exhibiting a breaking strength of at least 500 n, preferably of at least 1000 n.. .
GrÜnenthal Gmbh


Hair care polymer

The invention relates to specific quaternized hyperbranched polymers having end-groups of formula (i) characterized in that said quaternized hyperbranched polymer is obtainable by preparation of a hyperbranched polymer having dimethylamino end groups by condensation of 2-dodecen-1-ylsuccinic anhydride, diisopropanolamine and n,n-bis[3-(dimethylamino)propyl]amine followed by quaternization of the dimethylamino end-groups to end groups of formula (i). Furthermore, the invention is directed to clear shampoo preparations comprising such quaternized hyperbranched polymers..
Dsm Ip Assets B.v.


Strain sensor device with a biological substrate and manufacturing thereof

A strain sensor device having a biological substrate composed of a standalone bone graft or an isolated piece of bone that can be incorporated directly into, or attached to another piece of bone that is then implantable, in a biological subject, and a method thereof. The strain sensor device can includes a strain sensing circuit, which is composed of at least a first dielectric layer and a first conductive layer, that functions as a strain gauge.
Innovative In Vivo Sensing, Llc


Synergistic microbicidal combinations

Antimicrobial compositions based on the synergistic combination of 2-methyl-3-isothiazolone and selected commercial microbicides where the compositions are substantially free of halogenated 3-isothiazolone, are disclosed. Particularly preferred are combinations of 2-methyl-3-isothiazolone together with benzoic acid, citric acid, sorbic acid, 1,2-dibromo-2,4-dicyanobutane, 1,3-dimethylol-5,5-dimethylhydantoin, phenoxyethanol, benzyl alcohol, zinc pyrithione or climbazole, that provide enhanced microbicidal efficacy at a combined active ingredient level lower than that of the combined individual 3-isothiazolone and commercial microbicide effective use levels..
Rohm And Haas Company


Thermoelectric material and thermoelectric module

A thermoelectric material is manufactured by a manufacturing process including annealing at an annealing temperature from 125° c. To 200° c.
National Institute Of Advanced Industrial Science And Technology


Press belt in a paper-making machine

A press belt for a shoe-press device for dewatering or smoothing a fibrous web, in particular a paper, cardboard, or tissue web. The press belt has a fiber-reinforced plastic matrix.
Voith Patent Gmbh


Method of applying an organosilane solution to rigid substrates and grout

A stain-treated substrate comprising an extremely thin coating for stain protection. The stain-treated substrate includes substrate material and the extremely thin coating include a molecular layer of organosilane 3-(trimethoxysilyl) propyldimethyl octadecyl ammonium chloride covalently bonded to the surface of the substrate material.


5,5-heteroaromatic anti-infective compounds

The invention provides a series of 5,5-heteroaromatic compounds, syntheses thereof, compositions thereof, and methods of using such compounds and compositions. Various embodiments provide methods of killing and/or inhibiting the growth of m.
University Of Notre Dame Du Lac


Crystals of dispiropyrrolidine derivatives

Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of mdm2 are provided. The present invention provides crystals of (3′r,4′s,5′r)-n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits mdm2 and has anti-tumor activity.
Daiichi Sankyo Company, Limited


Preparation of symmetrical and asymmetrical disulphides by reactive distillation of mixtures of disulphides

The process of the invention is particularly suited to the preparation of dimethyl disulphide or diethyl disulphide from a mixture of symmetrical and/or asymmetrical dialkyl disulphides.. .


Energy efficient the extraction of biomolecules from dilute aqueous solution

The present invention relates to the energy efficient and selective extraction of dilute concentrations of biomolecules, e.g., small organic compounds, e.g., one or more c2-c6 alcohols, one or more c3-c5 carboxylic acids, one or more c8-18 fatty alcohols, one or more c1-c18 dicarboxylic acids, one or more furfurals, one or more furans, one or more butanediols, one or more butadienes, and mixtures thereof, from an aqueous solution using liquid phase dimethyl ether (dme).. .
Phasex Corporation


Ionic liquid alkylation of 1-butene to produce 2,5-dimethylhexane

A process for producing dimethylhexanes (dmh) is provided. The dmh can be used to produce p-xylene.
Uop Llc


Treatment of obesity using non-daily administration of 6-o-(4-dimethylaminoethoxy) cinnamoyl fumagillol

The invention generally relates to methods of treating an overweight or obese subject, and treating overweight- or obesity-related conditions using non-daily administration of e.g, a metap-2 inhibitor.. .
Zafgen, Inc.


Pharmaceutical compositions containing dimethyl fumarate

Provided herein are compositions containing compounds, or pharmaceutically acceptable salts, that metabolize to monomethyl fumarate with certain pharmacokinetic parameters and methods for treating, prophylaxis, or amelioration of neurodegenerative diseases including multiple sclerosis using such compositions in a subject, wherein if the compositions contain dimethyl fumarate, the total amount of dimethyl fumarate in the compositions ranges from about 43% w/w to about 95% w/w.. .
Biogen Ma Inc.


Hair dye agent comprising aminopyrimidine derivatives

In which r1 is a c1-c4 alkyl group, r2 is a hydrogen atom, a c1-c8 alkyl group, a c2-c6 alkenyl group, a c1-c6 hydroxyalkyl group, a c2-c6 polyhydroxyalkyl group, a c1-c6 alkoxy group, a c1-c6 alkylamino group, a di-c1-c6 alkylamino group, a c1-c6 polyalkoxy group, a c1-c6 alkylamido-(c1-c6) alkyl group, wherein the amide function can be substituted by one or two groups x, or is an aryl group, y is an nh2 or an oh group, at least one coupler component selected from 3-amino-2-methylamino-6-methoxypyridine, 3-amino-6-methylphenol, 3-amino-2-hydroxypyridine, 1,3 -bis-(2,4-diaminophenoxy)propane, 2,7-dihydroxynaphthalene, 2-methylresorcinol, 2,5-dimethylresorcinol, 4-chlororesorcinol, 3-aminophenol, 2-amino-3-hydroxypyridine, 2-chloro-6-methyl-3-aminophenol, 2,6-dihydroxy-3,4-dimethylpyridine, 2-({3-[(2-hydroxyethyl)amino]-4-methoxy-5-methylphenyl}amino)ethanol, 2-({3-[(2-hydroxyethyl)amino]-2-methoxy-5-methylphenyl}amino)ethanol, 1-methoxy-2-amino-4-beta-hydroxy-ethylaminobenzene (lehmann's blue), 2,4-diaminophenoxyethanol, 5-amino-4-chloro-o-cresol, 2,4-dichloro-m-aminophenol, 2,6-dihydroxy-3,4-dimethylpyridine and/or a physiologically compatible salt of these compounds.. .


Methods of forming 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters and methods of using the same

Methods include formation of 4-chloro-2-fluoro-3-substituted-phenylboronic acid pinacol esters. The method comprises contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene.
Dow Agrosciences Llc


Method for preparing dialkyloxydianhyrohexitol by etherification of dianhydrohexitol using a light alcohol, in the presence of an acidic catalyst

A method for preparing a dialkyloxydianhyrohexitol (dimethylisosorbide) composition by etherification of dianhydrohexitol (isosorbide). The aim is to achieve a “clean” method that avoids the use of a methylation agent such as dimethyl sulfate or methyl chloride, which generates stoechiometric quantities of salts, or expensive dialkyl-carbonates, wherein only one of the two methyl groups participates in the preparation of mixed isosorbide ethers.
Universite Claude Bernard Lyon 1



A patch comprising a support layer and an adhesive layer, wherein the adhesive layer comprises diclofenac sodium, dimethyl sulfoxide, and citric acid; a mass ratio between the diclofenac sodium and the citric acid (mass of diclofenac sodium:mass of citric acid) is 1:0.15 to 1:0.45; and a mass ratio between the diclofenac sodium and the dimethyl sulfoxide (mass of diclofenac sodium:mass of dimethyl sulfoxide) is 1:0.75 to 1:3.. .
Hisamitsu Pharaceutical Co., Inc.


Insect repellent surface composition

Embodiments of the invention relate to a pest-control composition comprising at least one active ingredient and at least two other ingredients; wherein the at least one active ingredient is selected from the group consisting of geraniol, nootketone, amyl cinnamaldehyde, catnip, wintergreen, carvacrol, d-limonene, orange oil, lauric acid, alpha pinene, mint, cornmint oil, lemon oil, eucalyptus, eugenol, peppermint, lemongrass oil, and terpenes; and wherein the at least two other ingredients are selected from the group consisting of 2-propanol, alcohol, ethanol, monobutyl ether, ethylene glycol, terpenes, ethoxylated alcohol, dodecanol, ammonia, soap, lauryl polyglucose, polyethylene glycol, sodium lauryl sulfate, sodium olefin sulfonate, cocamidapropyl betaine, alkylbenzene sulfonate, polyoxyethelene alkylphenol sulfate, sodium dodecyl benzene sulfonate, sodium sterate, potassium sterate, potassium myristate, tomadol, polyglyceryl sterate, glycol monosterate, potassium oleate, polyglyceryl oleate, tween, polymers, acrylic polymers, ethyl cellulous, carboxymethyl cellulose, sodium hydroxide, ammonium hydroxide, polyacrylate polymer, polyvinyl pyrolidane, lauric diethanolamine, dimethyldodecylamine oxide, aspartic acid tetrasodium salt, and sodium citrate.. .
Tyratech, Inc.


Grafted para-aramid fiber and making

A method of making a fiber comprised of poly(p-phenylene terephthalamide) having monomer groups grafted onto the fiber surface, the method comprising the steps of (i) providing a fiber of poly(p-phenylene terephthalamide) that has been dried to remove adsorbed moisture, (ii) treating the fiber, in a non-polar solvent that will not dissolve the fiber, with a phosphazene base that exhibits a pka in dimethylsulfoxide of at least 21 so as to generate anions at the amide sites on the surface of the poly(p-phenylene terephthalamide) fiber, (iii) washing the base-activated fiber with an aprotic solvent, (iv) grafting a monomer onto the anion sites so as to introduce reactive functional groups onto the surface of the poly(p-phenylene terephthalamide) fiber, and (v) washing the grafted fiber of step (iv) with a protic solvent to extract any residual base compounds and grafting agents that are unbound to the surface of the fibers.. .
E I Du Pont De Nemours And Company


Compositions comprising enzyme-cleavable oxycodone prodrug

The embodiments provide compound kc-8, n-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, compound kc-8, that provides controlled release of oxycodone.
Signature Therapeutics, Inc.


Glycosaminoglycan and synthetic polymer material for blood-contacting applications

Provided herein is a composite, comprising: a polymer host selected from the group consisting of low-density polyethylene (ldpe), linear low-density polyethylene (lldpe), polyethylene terephthalate (pet), polytetrafluoroethylene (ptfe), and polypropylene (pp), polyurethane, polycaprolactone (pcl), polydimethylsiloxane (pdms), polymethylmethacrylate (pmma), and polyoxymethylene (pom); and a guest molecule comprising hyaluronic acid; wherein the guest molecule is disposed within the polymer host, and wherein the guest molecule is covalently bonded to at least one other guest molecule. Also provided herein are methods for forming the composite, and blood-contracting devices made from the composite, such as heart valves and vascular grafts..
Colorado State University Research Foundation


Microbial fermentation for the production of terpenes

The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and/or farnesene.
Lanza Tech New Zealand Limited


Process for producing renewable jet fuel compositions

Processes for producing jet fuel are disclosed. In one embodiment, syngas is converted to methanol, and a first portion of the methanol is converted to olefins using a methanol-to-olefins catalyst.


Process for the preparation of fluoroalkyl (alkyl carbonates and carbamates

Fluoroalkyl alkyl carbonates and fluorosubstituted carbamates which are suitable as additives or solvents in lithium ion batteries are prepared from fluoroalkyl fluoroformates and the respective alcohol or amine. Methanol is the preferred alcohol, dimethylamine and diethylamine are preferred amines.
Solvay Fluor Gmbh


Filaggrin gene expression promoter

The present invention provides a novel substance that promotes expression of filaggrin gene involved in improvement of the moisture retention function of skin. The inventors of the present invention found that expression of filaggrin gene fluctuates rhythmically over a roughly 24 hour cycle, screened candidate substances based on the time at which expression reaches a maximum following addition of the candidate substance, and identified zanthoxylum extract, 3-(1′-piperidine)propionic acid, geranium oil, cypress oil, rose oil, galvanum oil, pepper oil, basil oil, methyl-o-toluate, methyl anthranilate and dimethyl anthranilate as filaggrin gene expression promoting agents..
Shiseido Company, Ltd.


Fluoropolymer composition

The invention pertains to a fluoropolymer composition suitable for adhering a fluoropolymer coating onto a surface, in particular onto a metal surface, said composition comprising: at least one fluoropolymer [polymer (a)]; at least one aromatic polycondensation polymer [polymer (p)]; a solvent mixture [mixture (m)] comprising dimethylsulfoxide (dmso) and at least one solvent selected from the group consisting of diesters of formula (ide) and ester-amide of formula (1ea): r1—ooc-ade-coo—r2 (1de), r1—ooc-aea-co—nr3r4 (1ea) wherein: r1 and r2, equal to or different from each other, are independently selected from the group consisting of c1-c20 hydrocarbon groups; r3 and r4, equal to or different from each other, are independently selected from the group consisting of hydrogen, c1-c36 hydrocarbon groups, possibly substituted, being understood that r3 and r4 might be part of a cyclic n moiety including the nitrogen atom to which they are bound, said cyclic moiety being possibly substituted and/or possibly comprising one or more than one additional heteroatom, and mixtures thereof; ade and aea, equal to or different from each other, are independently a linear or branched divalent alkylene group, and to a method for coating a surface, specifically a metal surface, with a fluoropolymer, using said fluoropolymer composition.. .
Solvay Specialty Polymers Italy S.p.a.


Modified polyalkylene oxide

Wherein r2represents methyldiphenylene, hexamethylene, methyldicyclohexylene, 3-methyl-3,5,5-trimethylcyclohexylene, dimethylphenylene, or tolylene.. .


Plant extract and the process for treating hepatic fibrosis and liver cancer

An extract of graptopetalum paraguayense prepared by a method that includes: extracting a graptopetalum paraguayense (gp) starting material with an alcoholic solvent to produce an alcoholic extract and a residue; separating the residue from the alcoholic extract; extracting the residue with an aqueous dimethyl sulfoxide (dmso) solvent to produce a dmso extract; subjecting the dmso extract to ultrafiltration using a filter having a selected molecular weight cutoff; drying a fraction retained by the filter to obtain the extract of graptopetalum paraguayense. Uses of an extract of graptopetalum paraguayense for the treatment or prevention of liver fibrosis, hepatic cirrhosis, liver cancer, recurrence of liver fibrosis after surgery, or recurrence of liver cancer after surgery..
Development Center For Biotechnology


Drospirenone for hormone replacement therapy

A pharmaceutical composition comprising as a first active ingredient an estrogen, such as estradiol or estradiol valerate, in sufficient amounts to treat disorders and symptoms associated with deficient endogenous levels of estrogen in women, and as a second active ingredient 6β,7β;15β;16β-dimethylene-3-oxo-17α-preg-4-ene-21,17-carbolactone (drospirenone, drsp) in sufficient amounts to protect the endometrium from the adverse effects of estrogen is useful for, amongst others, treating peri-menopausal, menopausal and post-menopausal women. This composition may be used for hormone replacement therapy and may be administered as a multi-phased pharmaceutical preparation.
Bayer Intellectual Property Gmbh

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Dimethyl topics: Physiologic, Hydrochloric Acid, Fresnel Zone, Aberration, Ophthalmic, Liquid Crystal, Imaging System, Pharmaceutically Acceptable Salt, Pharmaceutically Acceptable Salts, Chloric Acid, Tartaric Acid, Fumaric Acid, Antagonist, Bradykinin, Enantiomer

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