Electrochemical impedance-based label-free and rapid biosensor for select bodily fluid biomolecule levels. Monoclonal antibodies to of biomolecule such as cortisol were covalently attached to a 16-mercaptohexadecanoic acid functionalized gold working electrode using zero-length crosslinkers n-(3-dimethylaminopropyl)-n-ethylcarbodiimide and 10 mm n-hydroxysulfosuccinimide. Cortisol was detected in phosphate buffered saline (simulated tear fluid) using a simple ferrocyanide reagent with a lower limit of ...

There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1′,6′-trichloro-4,1′,6′-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford ...

A crystal form of 2-(3,5-dimethyl-1h-pyrazol-1-yl)-5-methylphenol which is stable and has high purity for preservation, industrial manufacturing, and circulation, and process for providing the same by using a boron compound.

Uses are disclosed for a new crystalline molecular sieve designated ssz-102 synthesized using an n,n′-dimethyl-1,4-diazabicyclo[2. 2. 2]octane dication as a structure directing agent. Ssz-102 has esv framework topology.

The present invention relates to solid state forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (compound 1), pharmaceutical compositions thereof and methods therewith.

The present invention relates to pharmaceutical compositions containing dimethyl fumarate (dmf), more specifically, the present invention relates to a pharmaceutical composition for oral use in treating hyperproliferative, inflammatory or autoimmune disorders by administering a low daily dosage in the range of 410 mg±5% or 400 mg±5% dimethyl fumarate, wherein the pharmaceutical formulation is in the form of an erosion matrix ...

The viscosity of various ionic liquids (il), the solvent tetraethylene glycol dimethyl ether (g4), and their mixtures, with or without lithium salts, were measured experimentally. Various compositions were studied spectroscopically. Detailed analysis reveals that g4 preferentially solvates cations, leading to a reduction in the interaction energy between cations and anions and a subsequent enhancement in anion mobility. Diffusivity and ionic ...

There is provided a coating liquid capable of forming a coating film that is excellent in adhesiveness to the surface of a base material such as a metal, glass, or a resin even though the coating film contains pvdf which exhibits a remarkable non-tackiness and that can exhibit various desired functionalities such as non-tackiness, an antifouling property, chemical resistance, a ...

The disclosure concerns systems and methods for the production of phenol and acetone from cumene oxidation products. One method comprises reacting cumene and an oxidizing agent to produce a cumene oxidation product comprising cumene hydroperoxide and dimethyl benzyl alcohol, converting at least a portion of the dimethyl benzyl alcohol to cumene hydroperoxide by reacting the at least a portion of ...

The present invention relates to an aqueous alkanolamine solution demonstrating low volatility comprising 2-di-methylamino-2-hydroxymethyl-1, 3-propanediol useful for removing acid gases from gaseous mixtures. Said aqueous alkanolamine solution may further comprise one or more of an acid or acid-forming compound, another amino compound, an activator, a physical solvent, or one or more other compounds used in gal-liquid treatment practices. Further, ...

Liquid formulations of lactic acid addition salts of 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl]piperazine are provided.

This invention provides a method of treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome comprising administering to the subject laquinimod as an add-on therapy to or in combination with dmf. This invention also provides a package comprising laquinimod and dmf for treating a subject afflicted with multiple sclerosis or presenting a clinically isolated syndrome. This ...

The present disclosure is directed to alcohol-based anti-adherent compositions that do not adhere to or attract gram-negative and gram-positive bacteria once it is applied to a surface and dried. The composition may include as anti-adherent agents, hydrophilic film-formers such as cellulosics, gums, acrylates, nonionic polymers, and anionic polymers. Examples of anti-adherent agents include hydroxypropyl methylcellulose, cellulose gum, acacia senegal gum; ...

And also the preparation and use of the crystalline polymorph i of (4s)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (i).

An amorphous form of 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-yl-piperidin-1-yl)-11-oxo-6,11-dihydro-5h-benzo[b]carbazole-3-carbonitrile and a solid dispersion containing the amorphous form can be used extremely advantageously as drugs for oral administration.

The present invention relates to a process for the preparation of (1r,2r)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.

The present invention relates to an improved method for producing of 1-(5,5-dimethylcyclohex-1-en-1-yl)ethanone and 1-(5,5-dimethylcyclohex-6-en-1-yl)ethanone.

It is intended to provide a medicament and a method for treating cancer comprising a compound having mdm2 inhibiting activity and a compound having flt3 inhibiting activity in combination. The present invention provides a medicament comprising (3′r,4′s,5′r)—n-[(3r,6s)-6-carbamoyltetrahydro-2h-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2&#...

This charge-transporting material, which includes a charge-transporting substance, halo-tetracyanoquinodimethane, and a complexing agent comprising an amide compound such as 1,3-dimethyl-2-imidazolidinone, for example, and capable of forming a complex with halo-tetracyanoquinodimethane, and in which the halo-tetracyanoquinodimethane and complexing agent form a complex, makes it possible to provide a thin film having excellent charge-transporting properties and to realize an organic el ...

Provided is a method for preparing rebaudioside m by using an enzyme method. In the method, rebaudioside a or rebaudioside d is used as a substrate, and in the presence of sucrose and udp, rebaudioside m is generated by means of reaction of the substrate under the catalysis of a mixture of udp-glucosyl transferase and sucrose synthetase, or recombinant cells ...

The present disclosure relates to an improved method for producing ergothioneine, comprising the steps of: (a) inoculating pleurotus ostreatus strain cgmcc no. 6232 into a seed medium, and culturing it to prepare a seed liquor, wherein the seed medium uses soybean cake powder as nitrogen source; and (b) inoculating the seed liquor into a fermentation basal medium, and then culturing it ...