This page is updated frequently with new Differentiation-related patent applications.
|Workload differentiation for processor frequency scaling|
A method and device for controlling a frequency of a processor of a computing device are disclosed. The method includes receiving requests to process tasks on a processor of the computing device, classifying each of the tasks as either a new workload group or an historic workload group, and monitoring a load placed on the processor due to each of the workload groups.
Qualcomm Innovation Center, Inc.
|Gesture based user interface for augmented reality|
Technologies are generally described for systems and methods effective to provide a gesture keyboard that can be utilized with a virtual display. In an example, the method includes receiving sensory information associated with an object in proximity to, or in contact with, an input device including receiving at least one level of interaction differentiation detected from at least three levels of interaction differentiation, interpreting a command from the sensory information as a function of the at least one level of interaction differentiation, and outputting an action indication based on the command..
Empire Technology Development Llc
|Transgenic plant production producing genetically modified plant and genetically modified transgenic plant produced by same production method|
Provided is a transgenic plant production method for producing a genetically modified plant. The method is capable of efficient short term gene transfer, of introducing a target gene while retaining the useful traits of a plant undergoing gene transfer, and of efficient redifferentiation.
Sumitomo Rubber Industries, Ltd.
|Neo-islets comprising stem and islet cells and treatment of diabetes mellitus therewith|
Described are neo-islets comprising: a) dedifferentiated islet cells and mesenchymal and/or adipose stem cells; or b) redifferentiated islet cells and mesenchymal and/or adipose stem cells where the cells have been treated so as to facilitate redifferentiation. Further described herein are methods of generating neo-islets, the methods comprising: culturing a) dedifferentiated islet cells and mesenchymal and/or adipose stem cells; or b) redifferentiated islet cells and mesenchymal and/or adipose stem cells; on a surface that promotes the formation of cell clusters.
Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein..
The Regents Of The University Of California
|Methods of selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays|
The present invention relates to a method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays. More particularly, conducting polymers or metal oxides having exothermic characteristics upon irradiation of near infrared light is used as a cell culture scaffold, thus selectively attaching/detaching cells without an enzyme treatment.
Industry-academic Cooperation Foundation, Yonsei University
|Methods of modulating bone remodeling|
Disclosed herein, in certain instances, are methods of inhibiting osteoclast differentiation, bone resorption, bone formation, and bone remodeling in an individual in need thereof, comprising administering to the individual a composition comprising substantially fetal support tissue product including amniotic membrane and umbilical cord or an extract thereof, or a composition comprising substantially isolated hc-ha complex.. .
|Apparatus, systems, and methods for signal localization and differentiation|
Apparatus, systems, and methods for providing transmission and localized reception of audio, visual, and tactile signaling are taught for a myriad of useful purposes, including embodiments that permit differentiation between selected groups of intended recipients to permit simultaneous use of multiple instances of this technology in close proximity, if desired.. .
|Apparatus, systems, and methods for signal localization and differentiation|
Apparatus, systems, and methods for providing transmission and localized reception of data, aural, visual, and tactile signaling are taught for a myriad of useful purposes, including embodiments that permit differentiation between selected groups of intended recipients to permit simultaneous use of multiple instances of this technology in close proximity, if desired.. .
|Cd82-positive cardiac progenitor cells|
An object of the present invention is to provide a myocardial progenitor cell that is specifically induced to differentiate into a cardiomyocyte, and a method for preparing the myocardial progenitor cell. A method for preparing a cd82-positive cell includes, in sequence, a step (a) of obtaining stem cells, a step (b) of subjecting the stem cells to induction treatment of differentiation into cardiovascular cells, and a step (c) of separating, from the stem cells having been subjected to the induction treatment of differentiation in the step (b), a cd82-positive cell being negative for at least one cell surface marker selected from cd73, cd44, cd105, cd121a, cd18, and cd120a.
Iheart Japan Corporation
Method for in situ inhibition of regulatory t cells
The present invention pertains to engineered t-cells, method for their preparation and their use as medicament, particularly for immunotherapy. The engineered t-cells of the invention are designed to express both a chimeric antigen receptor (car) directed against at least one antigen expressed at the surface of a malignant or infected cell, and a secreted inhibitor of regulatory t-cells (treg).
Pharmaceutical composition comprising an anti-cd6 monoclonal antibody used in the diagnosis and treatment of rheumatoid arthritis
The present invention is related to the branch of immunology and particularly with the generation of pharmaceutical compositions containing a humanized monoclonal antibody recognizing the leukocyte differentiation antigen cd6. Accordingly with that statement, the purpose of this invention is to provide pharmaceutical compositions which contain a humanized anti-monoclonal antibody for the diagnosis and treatment of autoimmune diseases, particularly the rheumatoid arthritis..
Centro De Inmunologia Molecular
Aseptic medical instrument packaging with supporting peelable flaps
The present invention discloses an aseptic medical instrument packaging with supporting peelable flaps; the present invention gets the supporting peelable flaps by adding a material playing a supporting role and harder than the rest parts to the extending part outside a sealing edge of the peeling side of the packaging or adopting a material harder than the rest parts on the extending part outside a sealing edge of the peeling side of the packaging; a groove is carved in the junction between the outer edge of the sealing edge of the peeling side of the packaging; the material playing the supporting role comprises hard plastic, metal and paper. According to the present invention, a soft cover of the packaging is prevented from being inwards curled in the peeling process of the packaging; and when one or two peeling sides exist, the differentiation degree of the peeling side will be increased, such that medical staff can conveniently find the peeling side..
Immunoassay test device with two fluid flow paths for detection and differentiation of two or more analytes
A device for determining presence or absence of infection due to an infectious agent is described. The device comprises a sample receiving zone configured to receive a liquid sample from a subject suspected of having an infection due to an infectious agent, the sample receiving zone positioned to distribute the sample along a first fluid flow path to a first label zone and along a second fluid flow path to a second label zone.
Composition for inducing direct transdifferentiation into oligodendrocyte progenitor cells from somatic cells and use thereof
The present invention relates to a composition for inducing direct transdifferentiation into oligodendrocyte progenitor cells (opcs) from somatic cells, the composition containing at least one protein selected from the group consisting of direct transdifferentiation factors oct4, sox1, sox2, sox10, olig2, nkx2.2, and nkx6.2, a nucleic acid molecule coding the protein, or a vector including the nucleic acid molecule introduced thereinto; a pharmaceutical composition for preventing or treating spinal cord injuries or demyelination diseases; a cell therapy agent for preventing or treating spinal cord injuries or demyelination diseases; a cell therapy agent for treating spinal cord injuries or demyelination diseases; a composition for screening drugs for the treatment of spinal cord injuries or demyelination diseases; a 3d printing biomaterial composition for manufacturing artificial tissues for the treatment of spinal cord injuries or demyelination diseases; and a method for direct transdifferentiation into oligodendrocyte progenitor cells from somatic cells. According to the present invention, the oligodendrocyte progenitor cells are prepared from somatic cells through direct transdifferentiation, and thus can be favorably utilized for the treatment of spinal cord injuries and demyelination diseases..
Unist (ulsan National Institute Ofscience And Technology)
Three-dimensional silk fibroin scaffold culture retaining functional salivary cells and promoting salivary tissue-specific ecm synthesis
A cell culture system including a silk fibroid scaffold, culture media, and salivary gland cells. The salivary gland cells grown in the tissue culture system have physiological and morphological features like those of in vivo salivary gland cells.
The Board Of Regents Of The University Of Texas System
Compositions comprising citrate and applications thereof
In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells.
Board Of Regents, The University Of Texas System
Pharmaceutical compositions for inhibiting the osteoclast differentiation comprising eupatilin
Disclosed is a pharmaceutical composition comprising eupatilin as an active ingredient for suppressing osteoclast differentiation, bone metastasis, and osteolysis and for preventing or treating periodontitis. Found to effectively inhibit the differentiation of osteoclast progenitors into osteoclasts and the fusion of mononucleated osteoclasts into multinucleated osteoclasts, and reduce the bone resorption of w multinucleated osteoclasts, eupatilin is capable of effectively suppressing bone metastasis and osteolysis and may be used to prevent or treat periodontitis..
Osteoneurogen Co., Ltd
Method for assessing state of differentiation of cells
In the present invention, for test cells which are either stem cells whose state of differentiation is unknown or cells obtained from stem cells by differentiation induction, an lc-ms or gc-ms analysis is performed on culture supernatants collected from a culture dish of the test cells and a culture dish of control cells whose state of differentiation is known, and the state of differentiation of the test cells is assessed based on the amount, determined as a result of the aforementioned analysis, of at least one compound selected from the group of putrescine, kynurenine, cystathionine, ascorbic acid, riboflavin, pyruvic acid, serine, cysteine, threonic acid, citric acid, and orotic acid in both the culture supernatant of the test cells and the culture supernatant of the control cells.. .
Novel labelling cancerization-causing cell in stem cells, and therapy method
The invention provides a method to search for a best promoter for reliably targeting a cancerization-causing cell in human es/ips cells. Discovering a gene which can kill or remove a cancerization-causing cell contained in human es/ips cells with high efficiency is also provided.
System and a piezoelectric scaffold for nerve growth and repair
Provided is an electroactive structure for growing isolated differentiable cells comprising a three dimensional matrix of fibers formed of a biocompatible synthetic piezoelectric polymeric material, wherein the matrix of fibers is seeded with the isolated differentiable cells and forms a supporting scaffold for growing the isolated differentiable cells, and wherein the matrix of fibers stimulates differentiation of the isolated differentiable cells into a mature cell phenotype on the structure.. .
New Jersey Institute Of Technology
Carbonized material and inducing cell differentiation with the same
A method of inducing cell differentiation with a carbonized material, including the steps of: providing a fiber woven fabric, carbonizing the fiber woven fabric with high temperature to produce a carbonized material, and seeding a cell on the carbonized material where the fiber woven fabric includes a polyacrylonitrile fiber, the carbonized material includes a plurality of carbon fibers, wherein each of the plurality of carbon fibers includes a main body and a plurality of pillars located on a surface of the main body, and are piled up with randomly arranged axes oriented in various directions, and through attachment to the plurality of pillars during the carbonization process, the cell is induced to differentiate into a specialized cell.. .
Linkwin Technology Co., Ltd.
Composition for inducing differentiation
To provide a differentiation-inducing composition and a method for producing the differentiation-inducing composition, the present disclosure describes use of a degradation product containing at least a portion of the triple helical domain of collagen or atelocollagen.. .
Certain chemical entities, compositions, and methods
Chemical entities that are effective as kinase inhibitors, pharmaceutical compositions and methods of treatment are disclosed. The chemical entities disclosed specifically inhibit signal transduction and cellular proliferation by modulating the activity of protein kinases to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism.
Peptide having anti-inflammatory, osteogenic and hair growth promoting activities, and use of same
Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of seq id no: 1, seq id no: 2, and seq id no: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of seq id no: 1 and seq id no: 2.
Caregen Co., Ltd.
Model numerical solver for system control
A complete model numerical solver resides on an embedded processor for real time control of a system. The solver eliminates the need for custom embedded code, requiring only model equations, definition of the independent and dependent variables, parameters and input sources information as input to solve the model equations directly.
Engineered cellular pathways for programmed autoregulation of differentiation
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type.
The Trustees Of Princeton University
Differentiation of human embryonic stem cells into pancreatic endocrine cells
The present invention provides methods to promote differentiation of pancreatic endoderm cells to pancreatic endocrine rich clusters and to enhance insulin expression in hormone-expressing cells.. .
Janssen Biotech, Inc.
Method of producing skin-derived precursor cells
A method of producing skin-derived precursor cells, comprising culturing human-derived pluripotent stem cells in a differentiation-inducing medium containing an agonist of wnt signaling to differentiate the pluripotent stem cells into skin-derived precursor cells; a differentiation-inducing medium for differentiating human-derived pluripotent stem cells into skin-derived precursor cells, comprising an agonist of wnt signaling as a differentiation-inducing promoter; and a differentiation-inducing promoter for differentiating human-derived pluripotent stem cells into skin-derived precursor cells, comprising an agonist of wnt signaling as an active ingredient.. .
Method for inducing endodermal and mesodermal differentiation from human pluripotent stem cells by cxcr2 suppression
The present invention relates to a method of inducing the differentiation of human pluripotent stem cells into endoderm and mesoderm by cxcr2 inhibition, and more particularly, to a method of promoting the differentiation of human pluripotent stem cells into endoderm and mesoderm by inhibiting the expression of the surface receptor cxcr2 in the stem cells by use of an shrna technique. The method of inducing the differentiation of human pluripotent stem cells into endoderm or mesoderm by cxcr2 inhibition according to the present invention can increase the efficiency and utility of stem cells as a cell therapeutic agent, because it promotes the differentiation of stem cells into a specific germ layer serving as the origin of target cells, which is the first important step for inducing the differentiation of stem cells into specific cells..
Korea University Research And Business Foundation
Method for inducing ectodermal differentiation of embryoid bodies derived from human pluripotent stem cells by cxcr2 stimulation
The present invention relates to a method of inducing the differentiation of human pluripotent stem cell-derived embryoid bodies into ectoderm by cxcr2 stimulation, and more particularly, to a method of promoting the differentiation of human pluripotent stem cell-derived embryoid bodies into ectoderm by stimulating and activating the surface receptor cxcr2 of the embryoid bodies with the cxcr2-specific ligand gro-α. The method of inducing the differentiation of human pluripotent stem cell-derived embryoid bodies into ectoderm by cxcr2 stimulation according to the present invention can increase the efficiency and utility of stem cells as a cell therapeutic agent, because it promotes the differentiation of stem cells into a specific germ layer serving as the origin of target cells, which is the first important step for inducing the differentiation of stem cells into specific cells..
Korea University Research And Business Foundation
Conversion of somatic cells into nociceptors, and methods of use thereof
The present invention provides methods of transdifferentiation of somatic cells, e.g., a fibroblast, into a nociceptor cell, e.g., an induced nociceptor (inociceptors) with characteristics of a typical nociceptor cell. The present invention also relates to an isolated population comprising inociceptors, compositions, their use in the study of cellular and molecular mechanisms of peripheral pain generation and peripheral neuropathy, use in in vitro drug discovery assays, pain research, as their use in the treatment of nociceptive pain related diseases or disorders.
The General Hospital Corporation
Cell tracking reagents and their methods of use
Described herein are compounds, methods, and kits for short- and long-term tracking of cell proliferation, differentiation, and/or function. The compounds disclosed herein are rhodamine-based cell-tracking reagents that fluoresce in the red portion of the uv/vis spectrum and provide bright fluorescence intensity, uniform cell staining, and good retention within live cells as well as low toxicity toward cells..
Life Technologiies Corporation
Lpa receptor modulators for brown fat differentiation
Described herein is a method of increasing brown fat differentiation or increasing energy expenditure in a subject in need thereof, the method comprising administering to the subject an lpa receptor modulator, or a pharmaceutically acceptable salt, solvate, polymorph, prodrug, metabolite, deuteride, n-oxide, stereoisomer, or isomer thereof.. .
The California Institute For Biomedical Research
Sensorineural hair cell differentiation
The present disclosure provides compositions and methods for treating subjects at risk for or with sensorineural hearing loss. Such compositions and methods include modulating the epigenetic status of the cell, or rate of protein degradation, to increase expression and/or levels of atoh1 protein..
Massachusetts Eye & Ear Infirmary
Protection of progenitor cells and regulation of their differentiation
The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells..
Proteobioactives Pty Ltd.
Speaker diaphragm fabric and manufacturing method thereof
A method of manufacturing a speaker diaphragm fabric for a loudspeaker, includes: a preparation step, a plurality of first warps, at least one second warp and a plurality of wefts are prepared, wherein the second warp has characteristics different from the first warps; and a weaving step: the plurality of the first warps and the second warps are aligned and the wefts transversely cross and pass alternately over and under each of the first warps and the second warps in order to form the speaker diaphragm fabric having at least one formation region and a non-formation region exterior to the formation region. The second warps made from an inferior material are provided at the non-formation region, thereby reducing the waste cost and facilitating the differentiation of the formation region and the non-formation region..
Method for monitoring differentiation into cardiac muscle cells
A method for monitoring differentiation into cardiac muscle cells includes keeping, in an alive state, cells into which a reporter gene of luminescent protein configured to vary in luminescence intensity according to an expression of myocardial differentiation marker gene is introduced. The method includes acquiring a luminescence image as a still image by imaging light emitted from the cells in a light shielding state.
Methods for epicardial differentiation of human pluripotent stem cells
Methods for generating high-yield, high-purity epicardial cells are described. Wnt/β-catenin signaling is first activated in human cardiac progenitor cells, by, for example, inhibiting gsk-3 to induce differentiation into epicardial cells.
Wisconsin Alumni Research Foundation
Method for preparing and using cell ghost with active factors as synergist of lymphocyte in vitro culture
Provided is a method for preparing and using cell ghosts with active factors as a synergist of a lymphocyte in vitro culture. The method for preparing cell ghosts comprises: washing a cell to obtain a washed cell; and cleaving the washed cell to obtain cell ghosts, wherein the cell has cytokines capable of promoting the proliferation and differentiation of lymphocytes on their surface..
Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons
The present invention relates to a method for producing mammalian neural plate border stem cells (npbscs), comprising: (a) differentiation of mammalian pluripotent stem cells by (a-i) culturing mammalian pluripotent stem cells in pluripotent stem cell medium for about 24 to about 96 hours, wherein the pluripotent stem cell medium comprises: (i) an inhibitor of the activin/tgf-β signalling pathway; (ii) an inhibitor of the bmp signalling pathway; (iii) an activator of the canonical wnt signalling pathway; and (iv) an activator of the hedgehog signalling pathway; subsequently (a-ii) culturing the cells obtained in step (a-i) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises: (i) an inhibitor of the activin/tgf-β signalling pathway; (ii) an inhibitor of the bmp signalling pathway; (iii) an activator of the canonical wnt signalling pathway; and (iv) an activator of the hedgehog signalling pathway; subsequently (a-iii) culturing the cells obtained in step (a-ii) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises: (i) an activator of the canonical wnt signalling pathway; (ii) an activator of the hedgehog signalling pathway; and (iii) an inhibitor of oxidation; and (b) plating the obtained differentiated mammalian pluripotent stem cells in npbscs expansion medium, wherein the npbscs expansion medium comprises (i) an activator of the canonical wnt signalling pathway; (ii) an activator of the hedgehog signalling pathway; and (iii) an inhibitor of oxidation; and expanding the cells in the npbscs expansion medium for about 24 to about 96 hours; (c) splitting the cells obtained in (b) and further expanding the cells in the npbscs expansion medium; and (d) repeating step (c) at least two times. The present invention further relates to neural plate border stem cells obtainable by the method of the invention and the use of the cells of the invention in medicine..
Max-planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
Sp35 antibodies and uses thereof
Endogenous sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous sp35 function, such anti-sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction.
Biogen Ma Inc.
Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation
Disclosed are methods of obtaining an expanded population of mammalian ex vivo cells for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested or left at the engraftment site.
Montefiore Medical Center
Myoblast differentiation promoter
A peptide selected from the group consisting of ala-hyp-gly, hyp-gly-pro, leu-hyp, glu-hyp, gly-pro-hyp, pro-ala, hyp-gly and pro-hyp, or a pharmaceutically acceptable salt thereof has a myoblast differentiation promoting effect superior to conventional arts.. .
Nitta Gelatin Inc.
Material differentiation with phase contrast imaging
A method and system to determine material composition of an object comprises capturing a series of digital radiographic images of the object using a single exposure energy level. An intensity of the captured images is determined as well as phase shift differences.
Carestream Health, Inc.
Noninvasive diagnosis of fetal aneuploidy by sequencing
Disclosed is a method to achieve digital quantification of dna (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated.
The Board Of Trustees Of The Leland Stanford Junior University
Method for differentiation into biocompatible keratocyte progenitor cells and keratocyte progenitor cell composition
Disclosed is a method for differentiation into biocompatible keratocyte progenitor cells, the method including: providing human turbinate mesenchymal stem cells (htmscs) from a tissue source; and culturing the provided human turbinate mesenchymal stem cells (htmscs) in a keratocyte differentiation medium supplemented with keratocyte growth factor (kgf), so that a differentiable keratocyte precursor cell composition that is impossible in the conventional art can be implemented, and the injection of the keratocyte progenitor cell composition into patients can produce a short-term treatment effect while securing the transparency of the cornea.. .
Postech Academy-industry Foundation
Anterior endoderm cells
Disclosed herein are cell cultures comprising pdx1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified pdx1-positive endoderm cells as well as methods for enriching, isolating and purifying, pdx1-positive endoderm cells to other cell types.
Methods, compositions, and systems for activation and expansion of cells
The disclosure provides for compositions, systems, and methods of cell expansion, stimulation and/or differentiation. The disclosure further provides for a mesh substrate and associated methods capable of stimulating cell expansion, for example, t cell or stem cell expansion.
The Trustees Of Columbia University In The City Of New York