This page is updated frequently with new Differentiation-related patent applications.
|Data processing method and data processing apparatus|
A sample point extraction unit (323) extracts natural defect candidate portions by using sample points comprising height data for one line obtained by scanning once around the measurement surface of a tire surface. Natural defect candidate portions include natural defect portions and intentional irregularity portions, such as characters and patterns.
Kabushiki Kaisha Kobe Seiko Sho (kobe Steel, Ltd.)
|Method for determining the cardio-generative potential of mammalian cells|
This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a cardiac generation potential index (carpi) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation..
Cardio3 Biosciences Sa
|Compositions and methods for producing and administering brown adipocytes|
The present disclosure provides compositions comprising a hydrogel and a cell adhesion ligand that enhances the differentiation of mesenchymal stem cells into brown adipocytes, and/or enhances the maintenance of brown adipocytes. In some cases, a subject composition includes cells that are embedded within the hydrogel.
The Regents Of The University Of California
|Method for highly efficient conversion of human stem cells to lineage-specific neurons|
The present invention relates to the field of stem cells. More specifically, the present invention provides methods and compositions useful for the highly efficient conversion of human stem cells to lineage-specific neurons.
Kennedy Krieger Institute, Inc.
|Therapeutic antibodies and their uses|
The present invention relates to antibodies, e.g., full length antibodies or antigen binding fragments thereof, that specifically bind to bcma (b-cell maturation antigen) and/or cd3 (cluster of differentiation 3). The invention also relates to antibody conjugates (e.g., antibody-drug-conjugates) comprising the bcma antibodies, compositions comprising the bcma antibodies, and methods of using the bcma antibodies and their conjugates for treating conditions associated with cells expressing bcma (e.g., cancer or autoimmune disease).
|Novel active ingredient in cicatrization and use thereof|
The present invention relates to the use of a known compound as an agent for promoting and/or accelerating fibroblast proliferation and/or differentiation and, consequently, cicatrization. This compound is a copolymer of a 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulphonic acid salt and of propenoic acid 2-hydroxyethyl ester.
|Novel fat accumulation inhibitory peptide and pharmaceutical composition for preventing or treating obesity containing the same|
The present invention relates to a fat accumulation inhibitory peptide which essentially comprises an amino acid sequence represented by seq id no: 1, a pharmaceutical composition for preventing or treating obesity, which contains the peptide, and a health functional food for preventing or alleviating obesity, which contains the peptide. The fat accumulation inhibitory peptide according to the present invention has the function of inhibiting the differentiation of mesenchymal stem cells into adipocytes to thereby inhibit the accumulation of adipose tissue.
Nano Intelligent Biomedical Engineering Corporation Co. Ltd.
|Gear pump or motor|
The disclosure allows a gasket to be securely attached to a gasket groove, reduces a time for an operation of attaching the gasket to the gasket groove, and allows differentiation between gaskets of different materials. A gear pump or a motor, including gears which mesh together and form a pair, axes for pivotally supporting the gears, a body having a gear storing chamber internally for placing the gears, a cover for covering the gear storing chamber of the body, is characterized in that a gasket is disposed between the body and the cover, wherein the gasket is insertable to a gasket groove disposed on at least one of the body and the cover, the gasket groove having a shape surrounding the gear storing chamber, and the gasket sticks closely to the gasket groove due to an elastic restoring force when inserted to the gasket groove..
|Dendritic cell modulatory molecule|
The present invention provides a dendritic cell modulatory molecule which modulates, and preferable inhibits, the differentiation and maturation of mammalian dendritic cells. The invention also provides pharmaceutical compositions comprising the dendritic cell modulatory molecule and homologues and active fragments thereof, antibodies thereto and methods of treatment and screening methods which utilise such molecules..
Natural Environment Research Council
|Method for differentiating induced pluripotent stem cells into renal proximal tubular cell-like cells|
There is provided a method of differentiating an induced pluripotent stem cell (ipsc) into a renal proximal tubular cell (ptc)-like cell. The method comprises culturing an undifferentiated ipsc in a renal epithelial cell culture medium in the presence of one or more extracellular matrix (ecm) molecules, bone morphogenic protein 2 (bmp2) and bone morphogenic protein 7 (bmp7), for a period of from about 8 to about 10 days, under conditions sufficient to induce differentiation of the ipsc into a ptc-like cell.
C/o Agency For Science, Technology And Research
Serum-free chemically defined cell culture medium
Embodiments of chemically defined cell culture media containing nutrients and growth factors free of any serum for culturing cells such as mesenchymal stem cells and methods of using embodiments of the cell culture medium for expanding cell populations such as mesenchymal stem cells while maintaining a pluripotent phenotype and methods of inducing chondrogenesis and osteogenesis of mesenchymal stem cells by admixing differentiation factors into embodiments of the cell culture medium.. .
Core-centered granule composed of micro-structure body
Granules useful for bone regenerative filler that exhibit enhanced cell migration and proliferation and differentiation.. .
The Trustees Of Columbia University In The City Of New York
Composition for promoting differentiation or proliferation of erythrocytic cells, containing monoacetyl diacylglycerol compound as active ingredient
The present invention relates to compositions for promoting differentiation or proliferation of erythrocytic cells containing a monoacetyl diacylglycerol compound as an active ingredient, and pharmaceutical compositions and health functional food compositions for preventing, treating or alleviating erythrocytopenia containing the same. The monoacetyldiacylglycerol compound of the present invention is effective in promoting differentiation or proliferation of erythrocytic cells.
Korea Research Institute Of Bioscience And Biotech Nology
Systems and methods for operating secure elliptic curve cryptosystems
Various embodiments of the invention implement countermeasures designed to withstand attacks by potential intruders who seek partial or full retrieval of elliptic curve secrets by using known methods that exploit system vulnerabilities, including elliptic operation differentiation, dummy operation detection, lattice attacks, and first real operation detection. Various embodiments of the invention provide resistance against side-channel attacks, such as sample power analysis, caused by the detectability of scalar values from information leaked during regular operation flow that would otherwise compromise system security.
Maxim Integrated Products, Inc.
Screening assay for agents that influence beta cell number and/or phenotype
The present invention in general relates to a method for identifying compounds that influence beta cell number and/or phenotype, more in particular beta cell differentiation, proliferation and/or expansion. Said method comprising culturing beta cells or precursors thereof in 5 medium comprising glucose, and determining the ability of said compound to induce the glucocorticoid receptor dependent-transactivation pathway in said beta cells.
Methods of using mirnas from bodily fluids for detection and monitoring of parkinson's disease (pd)
The invention is directed to methods for early diagnosis, progression and treatment monitoring of parkinson's disease (pd) and its differentiation from other neurodegenerative diseases by quantifying brain-enriched mirna in bodily fluids.. .
Nucleic acid, pharmaceutical composition and uses thereof
Provided are a small interfering nucleic acid against bone formation inhibiting gene ckip-1, a pharmaceutical composition thereof, and uses thereof in preparation of a pharmaceutical composition for treating and/or preventing diseases related to the abnormal expression of ckip-1 gene. The small interfering nucleic acid is capable of cross-species inhibiting the ckip-1 gene expression, inhibiting ckip-1 expression in human, rhesus, rats and mice simultaneously, and facilitating the differentiation of osteoblasts and mineralization of bone matrix effectively..
Suzhou Ribo Life Science Co., Ltd.
Method for differentiating pluripotent stem cell induced from mesenchymal stem cell into adipocyte
The present invention relates to a medium composition containing an ecklonia cava extract for dedifferentiation an induced pluripotent stem cell. Also, the present invention relates to a method for differentiating an induced pluripotent stem cell produced by using the medium composition into adipocytes.
Bbhc Co., Ltd.
Methods for efficient generation of gabaergic interneurons from pluripotent stem cells
Enhanced methods for the generation of medial ganglionic eminence (mge) cells from pluripotent stem cells are provided that involve an additional step of contacting the cells with an activator of fgf8 signaling while differentiating pax6− cells progenitor cells into mge cells with an activator of sonic hedgehog, and optionally a wnt inhibitor. The activator of fgf8 signaling shifts the differentiation of the population of cells to nkx2.1+mge cells, rather than to coputfii+ caudal ganglionic eminence (cge) cells.
The Mclean Hospital Corporation
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Topographical templating of polymeric materials using cellular morphology
Substrates for influencing the organization, spreading or adhesion of a selected cell to induce or stimulate growth, differentiation on regeneration of the cell or of tissue constituting the cells are provided as well as methods of making such substrates and methods of using such substrates.. .
Methods of generating intermediate mesoderm cells from human pluripotent stem cells
Described herein are methods related to generating intermediate mesoderm (im) cells, including using sequential treatment of small molecules and growth factors, and composition produced by the described methods. Using small molecules such as chir99021 in combination with fgf2 and ra, efficient differentiation of human pluripotent stem cells (hpscs) into intermediate mesoderm, such as pax2+lhx1+ cells, is achieved.
The Brigham And Women's Hospital, Inc.
Method for differentiating pluripotent stem cell induced from mesenchymal stem cell into hepatocyte
The present invention relates to a medium composition containing an ecklonia cava extract for dedifferentiation an induced pluripotent stem cell. Also, the present invention relates to a method for differentiating an induced pluripotent stem cell produced by using the medium composition into hepatocytes.
Bbhc Co., Ltd.
Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals
Wherein a, y, z, r3 to r6, r20 to r22 and r50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (edg-2, edg2), which is activated by lysophosphatidic acid (lpa) and is also termed as lpa1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example.
Suspension controlling vehicle
A suspension controlling apparatus for a vehicle includes a suspension whose damping force is variably settable and a control unit capable of controlling the damping force of the suspension on the basis of a target damping force, to control the damping force of the suspension with a desired control amount and a high responsibility. A control unit includes a acceleration calculation device for calculating an acceleration in a forward and rearward direction of a vehicle on the basis of an operation input amount to the vehicle and a target damping force setting device for determining a target value of damping force on the basis of a damping force map determined in advance in response to the acceleration and a differentiation value of the acceleration..
Honda Motor Co., Ltd.
Directed cardiomyocyte differentiation and ventricular specification of stem cells
Disclosed is a fully chemically defined, small molecule-mediated, directed differentiation system that promotes differentiation of stem cells, including embryonic stem cells, induced pluripotent stem cells, and adult stem cells, such as human forms of these stem cell types, to ventricular cardiomyocytes in a highly efficient, reproducible and scalable fashion. Also disclosed is a cost-effective and efficient protocol, or method, for generating cardiomyocytes and a cost-effective and efficient method of maturing cardiomyocytes.
The University Of Hong Kong
Waveform shaping filter, integrated circuit, radiation detection device, adjusting time constant of waveform shaping filter, and adjusting gain of waveform shaping filter
A waveform shaping filter according to an embodiment includes at least one filter stage and a control circuit. The filter stage includes a differentiation signal generation circuit, a proportional signal generation circuit, and an adder circuit.
Kabushiki Kaisha Toshiba
System and the structuring and interpretation of organic computer programs
In various aspects, a system and method for the structuring and interpretation of organic computer programs may provide for programs to expand, grow and evolve after initiation in a manner that may be analogous to the way plants, animals, and organisms in nature that grow and evolve over time after their building blocks are assembled. The organic computing system and method may unify program design time and program run time, may provide for program structure and program state to change at run time, and may provide for programs to continuously change and evolve through the addition of member functions, inputs, and outputs as the program is running.
Method and device for combined detection of viral and bacterial infections
A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections.
Rapid Pathogen Screening, Inc.
Reprogramming of cells to a new fate
The present invention generally provides methods and compositions for transdifferentiation of an animal cell from a first non-pluripotent cell fate to a second non-pluripotent cell fate. Also provided are methods and compositions for the transdifferentiation of an animal cell from a non-pluripotent mesodermal, endodermal, or ectodermal cell fate to a different non-pluripotent mesodermal, endodermal, or ectodermal cell fate..
The Scripps Research Institute
Cell differentiation marker and its uses
Methods of using dub3 protein, a nucleic acid molecule coding for the protein, or an inhibitor of the activity and/or of the expression of the protein for modulating cell differentiation.. .
Centre National De La Recherche Scientique (cnrs)
Growth differentiation factor (gdf) for treatment of diastolic heart failure
The methods and uses described herein relate to the treatment of age-related conditions, e.g. By administering an agent that inhibits the interaction of gdf11 and follistatin.
The Brigham And Women's Hospital, Inc.
In vivo differentiation of relative oxygen levels and tumor necrosis using divalent europium
A method of magnetic resonance imaging a target tissue in a subject includes a step of administering a first eu2+-containing complex to the subject. The first eu2+-containing complex has a reduction potential that is more negative than a reduction potential for a selected compound present in the target tissue.
Wayne State University
Securinine and norsecurinine analogue compounds for the treatment of myeloid disorders
The present application relates to securinine or norsecurinine analogues that, when administered to immature myeloid cells, promote differentiation of these cells to mature cells that do not readily proliferate. Therefore, the agents are useful in the treatment of myeloid disorders including myeloproliferative disorders, acute myeloid leukemia, and autoimmune diseases.
Case Western Reserve University
Side channel analysis resistant architecture
A distributed technique for implementing a cryptographic process performs operations in parallel on both valid and irrelevant data to prevent differentiation of the operations based on an encryption key content. A control entity switches or points valid data to appropriate cpu(s) that are responsible for operations such as squaring or multiplying.
Marker system, in particular for baculovirus-expressed subunit antigens
The present invention belongs to the field of compliance markers and marker vaccines which allow for the differentiation between infected and vaccinated individuals. In particular, it relates to a method of determining whether an individual has received an immunogenic composition comprising a recombinant protein produced by a baculovirus expression system in cultured insect cells..
Boehringer Ingelheim Vetmedica, Inc.
Method for differentiating pluripotent stem cell induced from mesenchymal stem cell into osteoblast
The present invention relates to a medium composition containing an ecklonia cava extract for dedifferentiation an induced pluripotent stem cell. Also, the present invention relates to a method for differentiating an induced pluripotent stem cell produced by using the medium composition into osteoblasts.
Bbhc Co., Ltd.
Neuronal stem cell differentiation
The invention relates to at least one novel neural cell differentiation medium for the production of neural cells from at least one precursor cell capable of lineage specific differentiation; a method for neural cell differentiation using said medium; the use of said medium and said method for lineage specific differentiation of at least one precursor cell towards a neural cell fate; and a kit of parts comprising said at least one said neural cell differentiation medium.. .
Kdm1a inhibitors for the treatment of disease
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of kdmia, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia..
Imago Biosciences Inc.
Scaffold-free self-organized 3d synthetic tissue
The present invention can be used for actual implantation surgery without a scaffold. The present invention provides a synthetic tissue or complex which can be produced by culture and has a high level of differentiation ability.
Two Cells, Co., Ltd.
Method for preparation of induced dopaminergic progenitors using direct reprogramming
The present invention relates to a method for preparing induced dopaminergic neuronal progenitors (idps) comprising inducing an expression of oct4, sox2, klf4, and c-myc genes in adult cells and direct reprogramming of the adult cells to the idps by treating the cells with sonic hedgehog (shh) and fibroblast growth factor 8 (fgf8); and a cell therapy product and a composition for treating or preventing parkinson's disease (pd) which comprises the idps as active ingredients. In addition to this, the present invention relates to a method for preparing midbrain dopaminergic neurons comprising isolating nsc-like colony by culturing the idps, dissociating the isolated nsc-like colony, and culturing the cells on the neural cell differentiation medium.
Korea Research Institute Of Bioscience And Biotechnology
Compositions and methods for reprogramming eukaryotic cells
The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mrna encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mrna that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mrna was introduced, and compositions therefor. For example, the present invention provides mrna molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells..
The Trustees Of The University Of Pennsylvania
Differentiation and enrichment of islet-like cells from human pluripotent stem cells
Methods for differentiating human pluripotent stem cells into islet-like cells are provided. In certain embodiments, the methods utilize sequential culturing of the human pluripotent stem cells with certain factors to produce islet-like cells.
Asterias Biotherapeutics, Inc.
Reprogramming cardiomyocytes with one transcription factor
Compositions and methods are described herein for chemically inducing cells that express a single pluripotency transcription factor to change their differentiation state and become cardiac cells, cardiac progenitor cells, cardiomyocytes, or a combination thereof.. .
The J. David Gladstone Ins., A Testamentary Trust Established Under The Will Of J. David Gladstone
Method of obtaining terminally differentiated neuronal lineages and uses thereof
Provided is a method of inducing transdifferentiation of mesenchymal stem cells (msc), the method including (a) culturing msc in a first culture medium including a growth factor selected for allowing formation of neuralized msc (nmsc); (b) allowing the nmsc to proliferate for a sufficient time during which said culture medium is renewed at least once; and (c) culturing the nmsc of (b) in a second culture media including cerebrospinal fluid (csf) for a time sufficient for the nmsc to differentiate into a population of cells including terminally differentiated neurons, astrocytes and oligodendrocytes. Also provided by the present invention is the use of msc or nmsc for providing a composition including said population and to kits including msc or nmsc and instructions for use of same..
Hadasit Medical Research Services & Development Limited
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Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
Methods for producing substantially pure cultures of human neural retinal progenitor cells, forebrain progenitor cells, and retinal pigment epithelial cells are disclosed. In addition, the successful differentiation of human embryonic stem cells and human induced pluripotent stem cells through the major developmental stages of human retinogenesis is disclosed..
Wisconsin Alumni Research Foundation
Culture medium for establishing neuroepithelial stem cells, establishing neuroepithelial stem cells, and applications thereof
The present invention discloses a culture medium for establishing neuroepithelial stem cells, a method for establishing neuroepithelial stem cells, and the applications thereof, wherein the culture medium comprises differentiation culture medium for inducing and differentiating pluripotent stem cells to elementary neuroepithelial stem cells as well as proliferation culture medium for amplifying the elementary neuroepithelial stem cells; and the pluripotent stem cells can be differentiated to the elementary neuroepithelial stem cells in the differentiation culture medium. While the elementary neuroepithelial stem cells have the functions of the neuroepithelial stem cells, they cannot be stably amplified in long term culture under the conventional culture conditions, however they are maintained the stability properties in long term culture in the proliferation culture medium.
Yunnan Key Lab Of Primate Biomedicine Research
Muscle cell patches and uses therefor
Disclosed herein are contractile cell constructs comprising contractile cells, or progenitors thereof, adhered to a surface of a three dimensional fibroblast containing scaffold (3dfcs) and methods for using them to treat disease. In one aspect, the present invention provides methods for preparing a contractile construct, comprising (a) seeding immature contractile cells onto the surface of a three dimensional fibroblast containing scaffold (3dfcs) to produce a contractile construct; and (b) culturing the contractile construct under conditions to promote differentiation of the immature contractile cells into mature contractile cells, wherein the mature contractile cells form striations.
The United States Government As Represented By The Department Of Veterans Affairs
Method for preparing of endothelial cells by transformation (transdifferentiation) of adult fibroblast, and use thereof
The present invention relates to a method of preparing vascular endothelial cells by transforming (transdifferentiating) adult fibroblasts and a composition, which includes vascular endothelial cells prepared according to the method, for preventing and treating ischemic diseases, the method including a step of transducing adult fibroblasts with a gene. In particular, the present invention confirms that five factors, foxo1, er71, klf2, tal1, and lmo2, induce transdifferentiation of adult fibroblasts into induced vascular endothelial cells.
Seoul National University R&db Foundation
Small molecule cellular reprogramming to generate neuronal cells
Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become neuronal cells.. .
The J. David Gladstone Ins., A Testamentary Trust Established Under The Will Of J. David Gladstone
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Methods and compositions for diagnosis and prognosis of appendicitis and differentiation of causes of abdominal pain
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in appendicitis patients and in patients at risk for appendicitis. In particular, the invention relates to using assays that detect one or more biomarkers as diagnostic and prognostic biomarker assays in such patients..
Astute Medical, Inc.
Method and device for combined detection of viral and bacterial infections
A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections.
Rapid Pathogen Screening, Inc.
Phd gene involved in development and formation of plant phloem
Disclosed is a phd protein regulating the differentiation of plant phloem; a recombinant vector containing a gene encoding the same; a plant transformed with the recombinant vector; a seed of the plant; and a method for regulating the development and formation of plant phloem by using the gene encoding the phd protein. Regulated is the development of phloem, which plays the role in moving a photosynthetic product and finally storing the same in starch and sugar forms in a plant storage organ, so as to regulate the function of phloem, thereby having an effect of controlling the size and storage capacity of the plant storage organ.
Postech Academy-industry Foundation
Method for purification of retinal pigment epithelial cells
The present invention provides a method of purifying highly pure retinal pigment epithelial cells from a cell population obtained by induction of differentiation of pluripotent stem cells into retinal pigment epithelial cells, by a simple and easy operation in a short period. The purification method of the present invention includes a step of introducing a cell population containing retinal pigment epithelial cells obtained by differentiation induction of pluripotent stem cells on laminin or a fragment thereof on a filter, and obtaining a cell population that passed the filter..
Reprogramming of pluripotent stem cells for improved control of their differentiation pathways
The present invention relates to a method to reprogramming pluripotent stem cells (pscs) by epigenetic conditioning and metabolic reprogramming into p pscs with highly controllable biological functions, the cells obtained by said method as well as methods of using said cells.. .
Methods and systems for treatment of spinal disorders using trans-spinal direct current stimulation
Methods, systems and devices are disclosed for treating a spinal disorder by applying a source of direct current to a spinal cord in animals, including humans. Trans-spinal direct current stimulation (tsdcs) uses direct current via cathodal and/or anodal stimulation to induce cell proliferation, cell differentiation, and/or cell migration at or near the area of the spinal cord being treated, and up-regulates or down-regulates protein expression by cells at or near the area of the spinal cord being treated..
Pharmaceutical composition for preventing or treating osteoporosis which comprises neuropeptide y as active ingredient
The present invention relates to a pharmaceutical composition for preventing or treating osteoporosis which comprises neuropeptide y as an active ingredient. The neuropeptide y according to the present invention reduces the expression of a cell adhesion factor in osteoblasts in which a y1 receptor is present, and consequently an effect of releasing a haematopoietic stem cell from bone marrow into the blood is excellent.
Kyungpook National University Industry-academic Cooperation Foundation
Therapeutic uses of microvesicles and related micrornas
The present invention provides improved methods and compositions based on microvesicles for the treatment of various diseases, disorders and conditions. In particular, the present invention encompasses the recognition that microvesicles contain specific micrornas which may function as intercellular regulators involved in cell or tissue regeneration, remodeling, reconstruction, reprogramming or transdifferentiation.
The University Court Of The University Of Glasgow
Compositions and methods for mesenchymal/stromal stem cell rejuvenation and tissue repair by enhanced co-expression of telomerase and myocardin
A major risk factor for ischemic heart disease is advanced age. In adult bone marrow and other tissues, the number and function of stem cells decline with aging.
Co-releasing compounds & formulations thereof useful for inducing mitochondrial biogenesis and tissue repair
Provided are pharmacological methods of inducing through a unified set of molecular mechanisms the maturation of stem cells, methods of promoting mitochondrial biogenesis in a cell and tissue, methods of reducing pluripotency in a stem cell, and methods of promoting differentiation of a stem cell. In particular, the invention relates to methods for promoting tissue growth and/or tissue repair and/or improving tissue survival, preventing and treating fibrotic lesions and disorders..
Vital signal measuring estimating contact condition
A vital signal measuring apparatus is attached to a living body to measure a vital signal of the living body, which includes an amplifier, an a/d converter, a processing unit, an n-th-order differential signal output unit, and an output unit. The amplifier and the a/d converter constitute a vital signal measuring unit for measuring a vital signal from a vital signal sensor and outputting a first signal corresponding to the vital signal.
Asahi Kasei Kabushiki Kaisha
Method and controlling a reciprocating-piston engine having several cylinders
A method for controlling a reciprocating-piston engine encompassing several cylinders, including generating a discrete-time signal by measuring a state variable of the reciprocating-piston sensor by way of a sensor and an associated evaluation circuit, superimposing onto the signal a summand signal obtained by time differentiation of the signal, or filtering the signal, in such a way that an amplitude of the signal is selectively made larger or smaller at useful frequencies of the signal, and further processing the superimposed signal by way of a user function related to at least one cylinder. A corresponding apparatus, a corresponding computer program, and a corresponding storage medium are also provided..
Robert Bosch Gmbh
Th17 differentiation markers for acne and uses thereof
A method is described for using ror gamma t or ror alpha to diagnose acne and/or to screen inhibitors of th17 differentiation. Specifically described, are methods of inhibiting ror gamma t or ror alpha and use of the screened inhibitors in acne treatment..
Galderma Research & Development
Pri-mirna libraries and methods for making and using pri-mirna libraries
Provided are methods for the design, preparation, and use of non-native pri-micrornas (pri-mirnas), pri-microrna (pri-mirna) scaffolds, and libraries of non-native pri-mirnas employing pri-mirna scaffolds. Also provided are methods for identifying non-native pri-mirnas, combinations of two or more non-native pri-mirnas, and mirnas derived from the processing of such non-native pri-mirnas, which mirnas exhibit one or more desired functional activities.
Differentiation of human pluripotent stem cells to multipotent neural crest cells
The present invention relates to the differentiation of human pluripotent cells, including human pluripotent stems cells to produce a self-renewing multipotent neural crest cell population in a single step method without the requirement of isolation of intermediate cells and without appreciable contamination (in certain preferred instances, virtually none) with pax6+ neural progenitor cells in the population of p75+hnk1+ap2+ multipotent neural crest-like cells. The multipotent neural crest cell population obtained can be clonally amplified and maintained for >25 passages (>100 days) while retaining the capacity to differentiate into peripheral neurons, smooth muscle cells and mesenchymal precursor cells..
University Of Georgia Research Foundation, Inc.
Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic laterial sclerosis (als)
The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (psc). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of amyotrophic lateral sclerosis (als) in a human subject is also disclosed..
Method of producing retinal pigment epithelial cell
Provided are a production method of retinal pigment epithelial (rpe) cells that improves differentiation induction efficiency of pluripotent stem cells into rpe cells, and can provide highly pure rpe cells by a simple and easy operation in a short period, a culture method of rpe cells that can stably grow and culture a cell, a toxicity/efficacy evaluation method using rpe cells useful for transplantation therapy, and a therapeutic drug for a retinal disease. The invention relates to a production method of rpe cells, comprising adhesion culture of human pluripotent stem cells using a culture substrate coated with a laminin-e8 fragment, a culture method of rpe cells, comprising adhesion culture of rpe cells using a culture substrate coated with a laminin-e8 fragment, a toxicity or efficacy evaluation method using rpe cells obtained by producing or culturing by the method, and a therapeutic drug for a retinal disease, containing the rpe cells..
Methods and compositions for ex vivo generation of developmentally competent eggs from germ line cells using autologous cell systems
The present technology provides for methods for the directed differentiation of multi-potent cells, female germ line stem cells, or oogonial stem cells into oocytes, granulosa cells and/or granulosa precursor cells, i.e.,“synthetic granulosa cells.” the synthetic granulosa cells are useful in methods for growth and maturation of follicles or follicle-like structures and immature oocytes. Additionally, the synthetic granulosa cells are useful in methods of increasing ovarian derived hormones and growth factors in a subject in need thereof..
In vitro production of foregut stem cells
This invention relates to the differentiation of pluripotent cells (pscs) into foregut stem cells (fscs) using a definitive endoderm induction medium comprising a tgffi ligand, fibroblast growth factor (fgf), bone morphogenetic protein (bmp) and a pi3k inhibitor to differentiate the pluripotent cells into definitive endoderm cells and a foregut induction medium comprising a tgfβ ligand to differentiate the definitive endoderm cells into foregut stem cells (fscs). Methods of differentiation, populations of foregut stem cells, culture media and kits are provided..
Cambridge Enterprise Limited
Kdm1a inhibitors for the treatment of disease
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of kdm1a, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia..
Imago Biosciences, Inc.
Therapy for promoting cell growth
There is disclosed the use of a composition for promoting neuronal growth of neurons in tissues of the central or peripheral nervous system. There is also disclosed a method for inducing proliferation or differentiation of neuronal cells..
Moleac Pte. Ltd.
Method of enhancing hematopoietic cell transplantation
The invention relates to a method for enhancing the transplantation of hematopoietic cells to supplement or fully reconstitute the hematopoietic system, such as in myeloablated patients or patients otherwise deficient in hematopoietic cells. The method involves administering cd34+ cells having enhanced expression of one or more of aml-1, mysm1, hif1a, profilin-1, phospho-gsk-3beta, skp2, cbx7, bmi-1, tcf1, musashi-2, or fli1 at levels that provide desirable therapeutically effective amounts of self-renewal of the administered cells and desirable therapeutically effective amounts of differentiation of the administered cells into the various progeny cells of the hematopoietic system (i.e., therapeutically effective amounts of hematopoietic reconstitution).
Torque limiting system
The present invention relates to torque transfer and torque limiting system technology and applications. This invention relates to providing improved torque limiting systems that employ tolerance rings for controlling transmitting power between a single power-input shaft and one or more power-output shafts, which can protect mechanical equipment and drivetrains from damage by mechanical overload.
Bair-ling Technologies, Llc
Markers for differentiation of stem cells into differentiated cell populations
Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for generating induced pluripotent cells (ips) from human cells, differentiating the ips into differentiated cells, and identifying differentiation specific markers..
Regenerative Medical Solutions, Inc.
Chemically defined culture medium for stem cell maintenance and differentiation
The present invention is directed to a low protein medium for the culture of pluripotent stem cells comprising one or more polysaccharides. The medium of the present invention can support cell culture objectives, for example cell survival, maintenance, passaging, proliferation, pluripotency, cloning, differentiation and induced pluripotent stem (ips) cell derivation..
The U.s.a., As Represented By The Secretary, Department Of Health & Human Services
Treatment of diseases caused by abnormal lymphocyte function with an hdac6 inhibitor
An hdac6 inhibitor (a compound of formula i) is shown to reduce the pathogenesis associated with the b cell mediated autoimmune disease, systemic lupus erythematosus (sle) administration of a compound of formula i attenuated many of the symptoms characteristic of sle including splenomegaly, abnormal b cell differentiation, an increase in the number double-negative thymic t cells, an increase in the level of auto-antibodies such as anti-dsdna, immune complex-mediated glomerulonephritis and an increase in inflammatory cytokine production. Treatment with a compound of formula i also increased the number of the subject's splenic treg cells while removing circulating auto-antibodies inhibition of hdac6 altered bone marrow b cell differentiation by increasing the percentage of cells in the early-stage developmental fractions of both pro- and pre-b cells.
Virginia Tech Intellectual Properties, Inc.
An anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells
The present invention provides the compound ormeloxifene [3,4-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-methoxy chroman] as useful in inducing differentiation in wide range of myeloid leukemias including acute promyelocytic leukemia, acute myeloid leukemia and chronic myeloid leukemia where block in differentiation is common feature. Ormeloxifene induced differentiation that is marked by increase in differentiation marker proteins like c/ebpα and surface proteins such as cd11b and granulocyte colony stimulating factor receptor (gcsfr).
Council Of Scienticfic & Industrial Research
Mobile network operator (mno) control of wifi qos via eap/diameter
A mobile network operator (mno) may control wifi qos. 3gpp has specified control mechanisms for various levels of quality of service (qos) over the cellular access and core network.
Convida Wireless, Llc
Method for culturing mesenchymal stem cells according to cell size
A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 μm or less and culturing the mesenchymal stem cells in a medium containing calcium and magnesium and under a low oxygen condition.
Medipost Co., Ltd.
Use of cardiotrophin to modulate stem cell proliferation
Methods of promoting stem cell proliferation by contacting the cells with cardiotrophin-1 (ct-1) are provided. The methods may further include contacting the stem cells with one or more stem cell modulators that promote differentiation of the stem cells.
Ottawa Hospital Research Institute
Method for enucleating nucleated erythrocyte, and enucleation inducer
Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided are a method of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time by adding a compound derived from proopiomelanocortin (pomc) to an undifferentiated (nucleated) erythrocyte, and an enucleation inducer including the compound..
Kanazawa Medical University
Differentiation of rpe progenitors into neuron-like cells
A method of permanently culturing rpe cells under hypoxia, and differentiating the rpe cells into neuronal like cells.. .
Stemedica Cell Technologies, Inc.
Human ipsc-derived vascular-related and hematopoetic cells for therapies and toxicology/drug screenings
Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining ipsc-derived cell lines that are of higher purity and maintain cell type integrity better than current ipsc-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells.
The Usa, As Represented By The Secretary, Department Of Health And Human Services
Method for inducing differentiation of induced pluripotent stem cells and selecting the same
It is an object of the present invention to provide a method for highly efficiently inducing differentiation of ips cells into cells having functions of interest, and a method for selecting ips cells having high differentiation induction efficiency for differentiation of the ips cells into cells of interest from among the produced ips cells. The present invention relates to a method for inducing differentiation of induced pluripotent stem cells, which comprises culturing induced pluripotent stem cells on a structure comprising cells and/or a component derived from the cells, wherein the cells in the structure and the differentiation-induced cells are the same type of cell..
Medical devices containing rapamycin analogs
A medical device comprises a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature.
Methods and compositions for treating bone diseases
The invention provides methods and compositions for stimulating or promoting bone generation and regeneration, for stimulating or increasing differentiation, activation or function of osteoblasts, for inhibiting or decreasing differentiation, activation or function of osteoclasts, and for treating bone diseases such as osteonecrosis by administering to a subject a therapeutically effective amount of a pro-nerve growth factor (prongf) or a pro-brain derived neurotrophic factor (probdnf) or an analog, homolog, fragment or derivative thereof. The pro-nerve growth factor (prongf) or a pro-brain derived neurotrophic factor (probdnf) or an analog, homolog, fragment or derivative thereof may be a mutated or poorly hydrolyzed form of prongf or probdnf..
Methods of transdifferentiation and methods of use thereof
Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.. .
Tel Hashomer-medical Research, Infrastructure And Services Ltd.
Composition for treating or preventing bone diseases, comprising halofuginone as active ingredient
The present invention relates to a composition for treating or preventing bone diseases comprising halofuginone as an active ingredient and, more specifically, to a composition for treating or preventing bone diseases, comprising, as an active ingredient, halofuginone having an osteoclast differentiation inhibitory efficacy and an osteoblast differentiation stimulatory activity. The composition for treating or preventing bone diseases, comprising halofuginone as an active ingredient, according to the present invention, reduces the expression of th17 cells and increases the expression of treg cells, thereby representing an effect of inhibiting osteoclast differentiation and being capable of also effectively inhibiting bone resorption by osteoclasts.
The Catholic University Of Korea Industry-academic Cooperation Foundation
Sdn based interdomain and intradomain traffic engineering
A method is implemented by a centralized control plane device for a software defined networking (sdn) network. The method performs joint inter-domain and intra-domain traffic engineering as a single optimization process with location varying objectives.
Telefonaktiebolaget L M Ericsson (publ)
Communication system and phase error estimating method thereof
A communication system includes a receiving circuit and a phase error estimating circuit. The receiving circuit receives an input signal x, which has an input phase θ in a polar coordinate system.
Mstar Semiconductor, Inc.
Beat tone full waveform inversion
A full wave inversion (fwi) may utilize an amplitude-frequency-differentiation (afd) or a phase-frequency-differentiation (pfd) operation to form a velocity model of a subterranean formation utilizing recovered low wavenumber data. Received seismic data is processes to isolate two data signals at different frequencies.
Advanced Geophysical Technology Inc.
Open-loop natural thermal energy releasing system with partial reflux
An open-loop type heat equalization device utilizing the heat exchange fluid as the carrier to transmit the thermal energy of a natural thermal energy storage body to the temperature differentiation body at the exterior, and wherein the fluid inlet/outlet port (4011) of the pipeline structure (401) and a fluid inlet/outlet port (3012) of a pipeline structure (301) is often structured as an open state, and the space limiting and flow direction guiding structure of the heat exchange fluid (104) is nod provided, the main features of the present invention includes one or more than one of the 1) to 7) structural devices including: 1) installing the space limiting and flow direction guiding structure (201) of the heat exchange fluid (104) between the fluid inlet/outlet port (4011) of the pipeline structure (401) and a fluid inlet/outlet port (3012) of a pipeline structure (301) for allowing the heat exchange fluid (104) with thermal energy to be released from the fluid inlet/outlet port (4011) of the pipeline structure (401), and a part thereof is returned to the fluid inlet/outlet port (3012) of the pipeline structure (301) for flowing back to the heat gaining device (101); 2) installing an outward-expanding arc-shaped fluid chamber (108) at one or more than one of turning locations of the open-loop flowpath configured by the heat gaining device (101), the pipeline structure (301), the space limiting and flow direction guiding structure (201) and the pipeline structure (401) for temporally storing a part of the heat exchange fluid (104) and moderating the flow speed of the heat exchange fluid (104) with thermal energy for reducing the flow damping of the flowpath to the heat exchange fluid (104); 3) installing an auxiliary heating/cooling device (115); 4) installing an auxiliary fluid pump (107); 5) installing a heat exchange fluid temperature sensing device (ts201); 6) installing an environment temperature sensing device (ts202); and 7): installing an electric power control unit (ecu200).. .