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Differentiation patents



      

This page is updated frequently with new Differentiation-related patent applications.




Date/App# patent app List of recent Differentiation-related patents
02/04/16
20160033359 
 Edge propagating optical time domain reflectometer and  using the same patent thumbnailnew patent Edge propagating optical time domain reflectometer and using the same
An otdr system utilizes a laser source that is turned “on” and kept powered until its light reaches the end of the fiber span being measured (i.e., until the fiber span is fully illuminated). At any point in time after the fiber is fully illuminated, the laser source can be turned “off”.
Ii-vi Incorporated


02/04/16
20160032322 
 Microvesicles patent thumbnailnew patent Microvesicles
A method of producing a population of differentiated cells comprising: a) inducing differentiation in a first population of cells by applying an inducer to said cells, b) harvesting microvesicles produced from first population of cells, and c) inducing differentiation in a second population of cells by applying said microvesicles or a derivative thereof to said second population of cells wherein, said first population of cells is autologous to said second population of cells and wherein the inducer applied to said first population of cells is not present in said second population of cells or is only present in trace amounts. Also related methods of producing microvesicles, methods of medical and/or cosmetic treatment and related products and uses..
Lydac Neuroscience Limited


02/04/16
20160032250 
 Differentiation of human embryonic stem cells patent thumbnailnew patent Differentiation of human embryonic stem cells
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express nkx6.1 and insulin and minimal amounts of glucagon..
Janssen Biotech, Inc.


02/04/16
20160032247 
 Differentiation-inducing culture medium additive and use thereof patent thumbnailnew patent Differentiation-inducing culture medium additive and use thereof
Provided is a differentiation-inducing culture medium additive for inducing bone differentiation of at least one type of cell selected from the group consisting of a stem cell, a dental pulp cell, a periodontal ligament cell, a placenta, an amnion, and a fibroblast under a serum-free condition, and a use of the differentiation-inducing culture medium additive. The differentiation-inducing culture medium additive of the present invention for inducing differentiation of a stem cell under a serum-free condition at least contains at least one growth factor selected from the group consisting of egf, fgf, and pdgf; dexamethasone; and β-glycerophosphate.
Two Cells Co., Ltd.


02/04/16
20160032244 
 Method of inducing cellular differentiation using the notch3 receptor intracellular domain patent thumbnailnew patent Method of inducing cellular differentiation using the notch3 receptor intracellular domain
The present invention relates to the intracellular domain of notch3 that can activate signaling and initiate transcription, thereby initiating cellular differentiation in general, and neuronal differentiation in particular. The present invention includes the use of polynucleotide sequences that code, entirely or partially, for the intracellular domain of notch3, for the purpose of inducing cellular differentiation.

02/04/16
20160032242 
 A role for the perlman syndrome exonuclease dis3l2 in the lin28-let-7 pathway patent thumbnailnew patent A role for the perlman syndrome exonuclease dis3l2 in the lin28-let-7 pathway
The 3′-5′ exonuclease, dis3l2, is responsible for the decay of uridylated pre-let-7 mirna. Biochemical reconstitution assays revealed that 3′ oligouridylation stimulates dis3l2 activity in vitro, and knockdown of dis3l2 in mouse embryonic stem cells leads to the stabilization of pre-let-7 mirna.
Children's Medical Center Corporation


02/04/16
20160031837 
 Compounds for inducing proliferation and differentiation of cells, and methods of use thereof patent thumbnailnew patent Compounds for inducing proliferation and differentiation of cells, and methods of use thereof
The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention.
Massachusetts Institute Of Technology


02/04/16
20160030462 
 Methods of manipulating the fate of cells patent thumbnailnew patent Methods of manipulating the fate of cells
A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding rna species (cur), (b) a modified cur, or (c) a compound that modifies or affects cur, under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of rna:rna or rna:dna or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained.

02/04/16
20160030377 
 Lipid compositions for the treatment of gastro-intestinal disorders and the promotion of intestinal development and maturation patent thumbnailnew patent Lipid compositions for the treatment of gastro-intestinal disorders and the promotion of intestinal development and maturation
The present invention provides a use of a lipid composition for the preparation of a nutritional, pharmaceutical or nutraceutical composition or a functional food, for the prevention and treatment of gastrointestinal diseases and disorders, and for promoting intestinal development, maturation, adaptation and differentiation.. .
Enzymotec Ltd.


01/28/16
20160024473 
 Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro patent thumbnailMenstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro
The invention relates to highly proliferative stem cell obtained from menstrual fluid. The menstrual stern cells (menscs) may be cultured in vitro and exhibit mesenchymal stem cell (msc)-like properties and some culture and expansion advantages.
Cells For Cells


01/28/16
20160024472 

Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines


The present invention it was determined that dendritic cells could be derived from various sources including peripheral blood monocytes in the presence of only gm-csf without other cytokines if the monocytes were not activated. By preventing activation, such as by preventing binding of the cells to the surface of the culture vessel, the monocytes do not require the presence of additional cytokines, such as il-4 or il-13, to prevent differentiation into a non-dendritic cell lineage.
Northwest Biotherapeutics, Inc.


01/28/16
20160024220 

Pharmaceutical composition comprising an anti-cd6 monoclonal antibody used in the diagnosis and treatment of rheumatoid arthritis


The present invention is related to the branch of immunology and particularly with the generation of pharmaceutical compositions containing a humanized monoclonal antibody recognizing the leukocyte differentiation antigen cd6. Accordingly with that statement, the purpose of this invention is to provide pharmaceutical compositions which contain a humanized anti-cd6 monoclonal antibody for the diagnosis and treatment of autoimmune diseases, particularly the rheumatoid arthritis..
Centro De Inmunologia Molecular


01/28/16
20160022865 

Aligned fiber and use thereof


A scaffold comprising an aligned fiber. The invention further relates to a scaffold comprising one or more electrospun fibers wherein a fast fourier transform (fft) analysis result of the fibers have adjacent major peaks with about 180? apart from each other.
Lifenet Health


01/28/16
20160022358 

Catheter with omni-directional optical lesion evaluation


A catheter is adapted to ablate tissue and provide lesion qualitative information on a real time basis, having an ablation tip section with a generally omni-directional light diffusion chamber with one openings to allow light energy in the chamber to radiate the tissue and return to the chamber. The chamber is irrigated at a positive pressure differential to continuously flush the opening with fluid.
Biosense Webster, Inc.


01/21/16
20160021381 

Methods and systems for differentiation of video frames for achieving buffered decoding and bufferless decoding


Systems and methods of managing h.264 compliant video that lacks b frames include decoding without the use of a significant video frame buffer. This variant of the h.264 standard may include a flag indicating that the video does not include b frames.
Sony Computer Entertainment America Llc


01/21/16
20160019489 

Prioritizing business capability gaps


Method to perform an operation to prioritize capability gaps, the operation comprising determining, for each of a plurality of business objectives, a weighted effectiveness, criticality, and differentiation (ecd) score, and determining operation of one or more processors, a priority value for each of a plurality of capability gaps based on: (i) the weighted ecd score of each business objective, and (ii) a degree of support the respective capability gap provides towards fulfilling each business objective, wherein each priority value reflects a degree of importance of a capability subject to the respective capability gap.. .
International Business Machines Corporation


01/21/16
20160019480 

Prioritizing business capability gaps


Systems, methods, and computer program products to perform an operation to prioritize capability gaps, the operation comprising determining, for each of a plurality of business objectives, a weighted effectiveness, criticality, and differentiation (ecd) score, and determining operation of one or more processors, a priority value for each of a plurality of capability gaps based on: (i) the weighted ecd score of each business objective, and (ii) a degree of support the respective capability gap provides towards fulfilling each business objective, wherein each priority value reflects a degree of importance of a capability subject to the respective capability gap.. .
International Business Machines Corporation


01/21/16
20160018399 

Methods and materials for identifying and treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation


This document provides methods and materials involved in identifying mammals having lung adenocarcinoma characterized by neuroendocrine differentiation as well as methods and materials involved in treating mammals having lung adenocarcinoma characterized by neuroendocrine differentiation. For example, methods and materials for using ascl1 and ret expression levels to identify lung cancer patients having lung adenocarcinoma characterized by neuroendocrine differentiation are provided..
Mayo Foundation For Medical Education And Research


01/21/16
20160018310 

White blood cell analysis system and method


Systems and methods for analyzing blood samples, and more specifically for performing a white blood cell (wbc) differential analysis. The systems and methods screen wbcs by means of fluorescence staining and a fluorescence triggering strategy.
Abbott Laboratories


01/21/16
20160017285 

Neural progenitor cell differentiation


differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ecm) compositions, such as collagen i, iv, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ecm compositions.
Wake Forest University Health Sciences


01/21/16
20160017268 

Device and methods comprising microelectrode arrays for electroconductive cells


The present invention relates to the devices and method comprising microelectrode arrays for the differentiation, maturation and functional analysis of electroconductive cells, including muscle cells (including, but not limited to, cardiomyocytes, skeletal muscle myocytes and smooth muscle myocytes) and neuronal cells. The microelectrode present on the arrays can be used to stimulate and record from cells cultured on the substrate.
Arizona Board Of Regents For And On Behalf Of Arizona State University


01/21/16
20160015707 

Method of promoting remyelination


A method of promoting remyelination in a subject in need thereof includes administering to the subject a therapeutically effective amount of at least one (1,3) diazole compound, wherein the therapeutically effective amount is the amount effective to induce endogenous oligodendrocyte precursor cell (opc) differentiation in the subject's central nervous system.. .
Case Western Reserve University


01/14/16
20160011177 

Screening therapeutic agents for charcot-marie-tooth disease and self-differentiation motor neurons used therefor


The present invention relates to a method for the screening of a therapeutic agent for charcot-marie-tooth disease (cmt) using induced pluripotent stem cells and motor neurons differentiated therefrom. Particularly, the present inventors prepared induced pluripotent stem cells from the human fibroblasts originated from cmt patient.
Samsung Life Public Welfare Foundation


01/14/16
20160010099 

Recombinant plant cell, preparation method therefor, and producing target protein using same


Plant cells express a target protein, a production method thereof, and a method of producing a target protein using the same are disclosed. The plant cells have introduced therein a recombinant vector containing gene(s) encoding a target protein, and the plant cells include plant cambial meristematic cells (cmc) or callus.
Unhwa Corporation


01/14/16
20160010059 

Expansion of hematopoietic progenitor cells by histone methyltransferase g9a inhibition


The invention provides compositions and methods that may be used to prevent and/or decelerate differentiation of stem cells. The invention may be used to maintain and expand a population of stem cells from a human subject, thereby providing a substantially greater population of stem cells for clinical and therapeutic treatments for various diseases and disorders..
The Regents Of The University Of California


01/14/16
20160010056 

Method of inducing differentiation from pluripotent stem cells to germ cells


This invention provides a method of producing a primordial germ cell-like cell (pgclc) from an epiblast isolated from an embryo or an epiblast-like cell (epilc) induced from a pluripotent stem cell (psc), which comprises allowing the epiblast or epilc to express exogenous transcription factor(s) selected from the group consisting of: (i) blimp1, prdm14 and tfap2c; (ii) blimp1 and prdm14; (iii) blimp1 and tfap2c; (iv) prdm14 and tfap2c; and (v) prdm14; thereby inducing the epiblast or epilc into a pgc state without acquiring transient mesodermal program.. .
Kyoto University


01/14/16
20160010055 

Generation of thymic epithelial progenitor cells in vitro


Methods for generating thymic epithelial progenitor (tep) cells from pluripotent stem (ps) cells in vitro are provided. Compositions and systems of cell populations of tep cells as well as cells formed during different stages of differentiation of ps cells into tep cells are also disclosed.
The Regents Of The University Of California


01/14/16
20160008434 

Stem cell for therapeutic use which is derived from human monocyte, and inducing same


The present invention relates to stem cells obtained by culturing monocytes in the presence of (i) m-csf and (ii) at least one member selected from the group consisting of ganglioside and water-soluble plant-derived extract, thereby dedifferentiating the monocytes; a therapeutic agent for treating damaged cells, tissues or organs; a cell drug agent; a method of producing stem cells, a culture medium for dedifferentiating monocytes; a dedifferentiation inducing agent; a cell drug kit; a kit for producing dedifferentiated cells; and a pharmaceutical composition.. .
Otsuka Pharmaceutical Co., Ltd.


01/14/16
20160008404 

Postnatal stem cells and uses thereof


The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


01/07/16
20160005312 

Bicycle differentiation using video data analytics


A vehicular observation and detection apparatus and system incorporates a detection framework using video analysis to differentiate between motorized vehicles and bicycles for improved traffic flow and safety at intersections. The detection framework creates virtual zones overlaid on lanes of a roadway and analyzes input data representing objects in the virtual zones collected from one or more cameras positioned at or near the roadway..
Iteris, Inc.


01/07/16
20160003734 

Detection system and detecting corrosion under an outer protective layer


Incoherent millimetre wave, sub-millimetre wave and terahertz test signals are used to probe metal substrates that are covered by a protective coating or outer layer, such as paint or thermal insulation, obscuring direct assessment of the substrate. The incoherent test signals, which may be from a naturally occurring passive source (such as the sky) and/or from an active noise source, provide signal dispersion and angular variation of the test signals with respect to angular incidence to the substrate.
Subterandt Limited


01/07/16
20160002629 

Diagnostic and treatment for chronic and acute phase myeloid leukemia


Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form. Also provided are methods of reducing proliferation or promoting differentiation of a cancer cell having reduced level of numb or increased level of msi.
Duke University


01/07/16
20160002604 

Method for suppressing teratoma formation via selective cell death induction in undifferentiated human-induced pluripotent stem cells


According to the present invention, the present invention makes it possible to effectively selectively cause apoptosis only of undifferentiated induced pluripotent stem cells by causing induced pluripotent stem cells to differentiate into specific differentiated cells and then carrying out culturing in a differentiating culture medium comprising quercetin or ym-155, and, in the induced pluripotent stem cell differentiation method according to the present invention, only undifferentiated induced pluripotent stem cells that are a cause of teratoma formation are selectively caused to die, and thus differentiated differentiating cells are completely unaffected. In other words, the invention can be expected to ensure safety as the possibility of tumor formation during clinical use as a cell therapeutic agent is eliminated since the survival and functioning of the differentiated cells is maintained unchanged..

01/07/16
20160002602 

Bioengineered liver constructs and methods relating thereto


An in vitro liver organoid is provided along with methods of making and using the organoid. The liver organoid can be manipulated to have either immature or mature characteristics.
Wake Forest University Health Sciences


01/07/16
20160002600 

Composition for promoting cardiac differentiation of pluripotent stem cell comprising egfr inhibitor


The present invention provides a composition for promoting cardiac differentiation of a pluripotent stem cell containing an egfr inhibitor. The present invention also provides a kit for promoting cardiac differentiation containing an egfr inhibitor and a method for inducing cardiac differentiation of a pluripotent stem cell comprising culturing the pluripotent stem cell in a medium containing an egfr inhibitor..
Kyoto University


01/07/16
20160002366 

Conjugate compound and uses of same


Conjugate compounds of hyaluronic acid bonded to pentosan polysulfate, or salts or derivatives thereof, are shown to induce chondrogenic differentiation of a population of mesenchymal stem cells as observed by, amongst other indications, increased glycosaminogsycan (gag) production.. .
The University Of Queensland


01/07/16
20160002329 

Treatment of conditions involving demyelination


The invention provides methods of treating diseases, disorders or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of an sp35 antagonist. Additional methods include methods for inhibiting the binding of the sp35 polypeptide with the erbb2 polypeptide and a method for increasing erbb2 phosphorylation by contacting oligodendrocytes with an effective amount of a composition comprising an sp35 antagonist of the invention.
Biogen Ma Inc.


01/07/16
20160001654 

Power hop cancellation using an electronic limited slip differential


Vehicles, systems and a method for mitigating power hop in a vehicle are provided. The vehicle, for example, may include, but is not limited to a drivetrain, an electronic limited slip differential mechanically coupled to the drivetrain, and a controller communicatively coupled to the electronic limited slip differential, wherein the controller is configured to determine when the vehicle is experiencing a power hop event or when the vehicle may experience a future power hop event, and cause, when the vehicle is experiencing the power hop event or when the vehicle may experience the future power hop event, the electronic limited slip differential to apply torque differentiation pulses to the drivetrain.
Gm Global Technology Operations Llc


01/07/16
20160000974 

Composite matrix for bone repair applications


Composite fibrous and non-fibrous matrices of biocompatible, bioactive synthetic polymers and ceramics are described. The composite matrices support bone cell differentiation and may be used alone or with whole bone marrow, isolated mesenchymal stem cells and/or bone grafts for bone repair and bone regeneration..
New Jersey Institute Of Technoloty


01/07/16
20160000876 

Il-33 and treatment of neurodegenerative diseases


The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to therapies of neurodegenerative diseases.
University Of Eastern Finland (kuopion Kampus)


12/31/15
20150379709 

Method for adaptive computer-aided detection of pulmonary nodules in thoracic computed tomography images using hierarchical vector quantization and same


Provided are an apparatus and method for fast and adaptive computer-aided detection of pulmonary nodules and differentiation of malignancy from benignancy in thoracic ct images using a hierarchical vector quantization scheme. Anomalous pulmonary nodules are detected by obtaining a two-dimensional (2d) feature model of a pulmonary nodule, segmenting the pulmonary nodule by performing vector quantification to expand the 2d feature model to a three-dimensional (3d) model, and displaying image information representing whether the pulmonary nodule is benign, based upon the 3d model expanded from the 2d feature model, with duplicate information eliminated by performing feature reduction performed using a principal component analysis and a receiver operating characteristics area under the curve merit analysis.
The Research Foundation For The State University Of New York


12/31/15
20150376576 

Subpopulations of spore-like cells and uses thereof


Subpopulations of spore-like cells expressing specific cell surface and gene expression markers are provided. In one embodiment, the cells express at least one cell surface or gene expression marker selected from the group consisting of oct4, nanog, zfp296, cripto, gdf3, utf1, ecat1, esg1, sox2, pax6, nestin, sca-1, cd29, cd34, cd90, b1 integrin, ckit, sp-c, cc10, sf1, dax1, and scg10.
Vbi Technologies, L.l.c.


12/31/15
20150376574 

Pancreatic insulin-producing beta-cell lines derived from human pluripotent stem cells


Production of beta-cells from stem cells from pluripotent stem cells have always been significantly lacking in at least one of the following properties: 1) functional properties related to insulin-production and glucose signaling response, 2) mature phenotype such as biochemical markers or cell structures, 3) efficiency in production of differentiated cells. Described herein is multistep differentiation protocol which substantially overcomes all of the existing limitations.
Cedars-sinai Medical Center


12/31/15
20150376572 

Adipose-derived stem cells and lattices


The present invention provides adipose-derived stem cells (adscs), adipose-derived stem cell-enriched fractions (adsc-ef) and adipose-derived lattices, alone and combined with the adscs of the invention. In one aspect, the present invention provides an adsc substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells.

12/31/15
20150376568 

Undifferentiated cell elimination method


An object of the present invention is to provide a method for introducing a target substance into undifferentiated cells, and a carrier therefor, whereby the target substance can be specifically introduced into the undifferentiated cells by contacting the undifferentiated cells with an rbc2lcn-target substance fusion product in which rbc2lcn lectin is fused to the target substance. Particularly, an rbc2lcn-toxin fusion product in which rbc2lcn lectin is fused to a toxin functioning in cells or its domain having the ability to kill cells functions as an agent for eliminating undifferentiated stem cells and can be administered into a medium after inducing the differentiation of the stem cells to reliably kill only the stem cells in an undifferentiated state..
National Institute Of Advanced Industrial Science And Technology


12/31/15
20150376567 

Media for stem cells


The present invention relates to a medium for storing, preserving, culturing, and/or differentiating stem cells. The medium employs a synthetic thermo-responsive copolymer, dispersed in an aqueous vehicle, which allows the medium to be readily “switched” between a non-gelatinous (fluid) form and a gelatinous form by simply adjusting temperature across the gelling temperature of the medium.
The University Of Sheffield


12/31/15
20150376133 

C-met modulators and methods of use


The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-met, kdr, c-kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
Exelixis, Inc.


12/31/15
20150374738 

Compositions and methods for regulating cell growth and development


The invention relates to the field of basic biology, practical regenerative medicine, veterinary, cell biology and can be used to treat and prevent diseases, disorders or conditions associated with the violation of proliferation and differentiation of cells of different organs and tissues to activate the regeneration potential of human and animal organs and tissues at age-related changes and after extreme impacts, as well as for biomedical research. The present invention can be widely applied in the field of blood transfusion, organ transplantation, as well as serve as a general approach to the development of reliable methods to correct age-related changes in the elderly.
Aovart Gmbh


12/31/15
20150374643 

Composition for inducing differentiation into beige and brown adipocytes and inducing the same


A composition for inducing differentiation into beige adipocytes from white adipocytes, including butein, a butein derivative, or a pharmaceutically available salt thereof as an active ingredient, and a method of inducing the differentiation are provided. Increases in expressions of ucp-1 and prdm4 are confirmed using the active ingredient, that is, the butein or butein derivative, and therefore the composition is expected to be used in preventing or treating obesity, and more basically, for target treatment..
Gyeonggi Institute Of Science & Technology Promotion


12/24/15
20150372928 

Method and arrangement for qos differentiation of vpn traffic across domains


A node in a first network domain and a method performed thereby for transmitting a data packet to a vpn client in a second network domain, the node and the vpn client being part of a vpn, wherein the first and second network domain are connected by means of a third network domain are provided. The method comprises receiving, from an application server, a first packet comprising a first ip header and a payload; and determining a dcsp.
Telefonaktiebolaget Lm Ericsson


12/24/15
20150368713 

Method for generating retinal pigment epithelium (rpe) cells from induced pluripotent stem cells (ipscs)


High efficiency methods for producing retinal pigment epithelial cells from induced pluripotent stem cells (ipscs) are disclosed herein. The ipscs are produced from somatic cells, including retinal pigment epithelial (rpe) cells, such as fetal rpe stem cells.
The United States Of American, As Represented By The Secretary, Department Of Health And Human Serv


12/24/15
20150368618 

Modulation of cardiac stem-progenitor cell differentiation, assays and uses thereof


The present invention relates to endogenous cardiac stem-progenitor cells (ecscs). Provided herein are c-kitpos cd166pos ecscs that are negative for the hematopoietic marker, cd45 and the mast cell marker, tryptase.

12/24/15
20150368617 

Method for forming endothelial cells


The present application discloses a method of promoting differentiation and expansion of endothelial cells (ec) and cardiomyocytes from a pluripotent cell, which includes contacting the pluripotent cell with a rho-associated protein kinase (rock) suppressor.. .
Korea Advanced Institute Of Science And Technology (kaist)


12/24/15
20150368616 

Methods for induction of cell fates from pluripotent cells


A method of inducing pancreatic fates from human multipotent or pluripotent cells includes obtaining a cell population comprising human multipotent or pluripotent cells and providing the cell population with at least three of (i) an cxcr4 agonist, (ii) an egfr agonist, (iii) an fgfr agonist, (iv) an activin receptor agonist or an agent that stimulates smad3, (v) an il11r agonist or il6r agonist, (vi) a notch agonist, (vii) an rxr agonist or rar agonist, or (viii) a bmp inhibitor for a time effective to allow the differentiation of pancreatic precursor cells from the human multipotent or pluripotent cells.. .
The Cleveland Clinic Foundation


12/24/15
20150368102 

Hydrogen quality differentiation at refueling station


The present invention provides a process for dispensing gaseous hydrogen at a refuelling station comprising before dispensing dividing an initial hydrogen stream into at least two streams, wherein at least one of the streams is purified in a hydrogen purification step. In a further aspect the invention provides a system for dispensing gaseous hydrogen..
Shell Oil Company


12/24/15
20150366915 

Pharmaceutical preparations of human rpe cells and uses thereof


This disclosure provides the first description of hesc-derived cells transplanted into human patients. Results are reported for one patient with each of stargardt's macular dystrophy (smd) and dry age-related macular degeneration (amd).
Ocata Therapeutics, Inc.


12/17/15
20150365428 

Coordinated detection and differentiation of denial of service attacks


According to one embodiment, an analyzer module (am) within a same protected network and on-premise with a web application server (was) detects and distinguishes between types of denial-of-service (dos) attacks. The am tracks whether test http messages, which include test http request messages that a signal generation module (sgm) is configured to transmit to the was and test http response messages that the was is expected to transmit in response to the test http request messages, are timely received.
Imperva, Inc.


12/17/15
20150361401 

Induced pluripotent stem cell model for fabry disease and use thereof


The present invention relates to an induced pluripotent stem cell model of fabry disease, a preparation method thereof, and a use of the same for the study of fabry disease development and for the screening of a therapeutic agent for the disease. Particularly, fabry disease derived induced pluripotent stem cells (ipscs), embryoid body (eb), and vascular cells were developed and differentiated from fibroblasts originated from fabry disease patient, wherein the fabry disease originated ipscs displayed significantly reduced expression and activity of gla protein therein, compared with the normal cells, resulting in the accumulation of globotriaosylceramide (gb3, cd77).
Korea Advanced Institute Of Science And Technology


12/17/15
20150361399 

Cardiomyocyte differentiation


This invention provides a method for testing a factor for cardiogenicity which comprises differentiating human embryonic stem (hes) cells to cardiomyocytes in the presence and absence of the factor wherein the human embryonic stem (hes) cells are cultured under a serum free condition comprising co-culture in the presence of end-2 cells or serum-free extracellular medium therefrom, and measuring the differentiation in the presence and absence of the factor. This invention also provides a method for identifying a cardiogenic factor, which comprises differentiating human embryonic stem (hes) cells to cardiomyocytes in the presence or absence of the factor wherein the human embryonic stem (hes) cells are cultured under a serum free condition comprising co-culture in the presence of end-2 cells or serum-free extracellular medium therefrom, and identifying the factor that affects the differentiation of human embryonic stem (hes) cells to cardiomyocytes in the presence or absence of the factor..
Es Cell International Pte Ltd.


12/17/15
20150361396 

T cell balance gene expression, compositions of matters and methods of use thereof


This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences t cell balance, for example, th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences t cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence t cell balance in a variety of therapeutic and/or diagnostic indications..
The Brigham And Women's Hospital, Inc.


12/17/15
20150361029 

S1p modulating agents


Compounds of formula (i) can modulate the activity of one or more s 1p receptors. Sphingosine 1-phosphate (s ip) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (edg) receptor family, namely s1p1, s1p2, s1p3, s1p4, and s1p5 (formerly edg1, edg5, edg3, edg6 and edg8).
Biogen Ma Inc.


12/10/15
20150356967 

Generating narrative audio works using differentiable text-to-speech voices


An approach is provided in which a voice management system generates multiple audio test recordings using multiple text-to-speech (tts) voices that have different acoustic properties. The voice management system determines that a comparison between a first one of the tts voices and a second one of the tts voices reaches an acoustic differentiation threshold and, as a result, assigns the first tts voice to a first character and assigns the second tts voice to a second character.
International Business Machines Corporation


12/10/15
20150354004 

Method for nondestructive detection of mirna expression in cell and determination of cell type and state


The present invention provides a method for non-invasively detecting the expression levels of mirnas in cell media and determining the types and status of the cells, and specifically provides a method for determining the type and status of the cells according to the expression level of mirnas in a cell medium. The method comprises: culturing different types of cells, collecting the medium of the cells, extracting rnas from the medium, performing reverse transcription on the rnas, detecting mirnas in the cell medium by the fluorescent quantitative pcr method, and determining the types and status of the detected cells according to the relationship between the expression levels of mirnas in different types and status of cells and the expression level of the detected mirnas.
Institute Of Genetics And Developmental Biology, Chinese Academy Of Sciences


12/10/15
20150353897 

Method of generating multilineage potential cells


The present invention relates generally to a method of generating cells exhibiting multilineage potential and to cells generated thereby. More particularly, the present invention is directed to an in vitro method of generating mammalian stem cells from cd14+ mononuclear cells and to cells generated thereby.
Fuwan Pty Ltd


12/10/15
20150353895 

Differentiation of human embryonic stem cells into single hormonal insulin positive cells


The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides methods to produce a population of cells, wherein greater than 10% of the cells in the population express markers characteristic of single hormonal pancreatic beta cells..
Janssen Biotech, Inc.


12/10/15
20150353893 

Method for differentiation of pluripotent stem cells into cardiomyocytes


This application relates to a method for differentiating pluripotent stem cells (pscs) into cardiomyocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (hescs) and induced pluripotent stem cells (ipscs) into defined cardiomyocytes based on linked steps of chemically defined medium inductions..
Hoffmann-la Roche Inc.


12/10/15
20150353889 

Mait-like cells and manufacturing same


The object of the present invention is to provide a method for preparing induced pluripotent stem cells from mait cells, and providing induced pluripotent stem cells derived from mait cells. Another object of the present invention is to provide a method for preparing mait-like cells from induced pluripotent stem cells, and providing mait-like cells.
National University Corporation Hokkaido University


12/10/15
20150352156 

Growth factor sequestering and presenting hydrogels


Provided herein are hydrogel cell matrices, hydrogel cell matrix systems for the support, growth, and differentiation of a stem cell or progenitor cell and methods for making such hydrogel cell matrices.. .
The Regents Of The University Of California


12/03/15
20150348103 

Customer specific retail promotions


A customer specific promotion system for generating individualized promotions for customers is disclosed. The system may be implemented to differentiate prices on a customer-by-customer basis.

12/03/15
20150346210 

Multiplex assay for improved scoring of tumor tissues stained for pd-l1


Multiplex assays for improved scoring of tumor tissues stained with pd-l1 featuring pd-l1 staining in a first color plus staining of one or more differentiating markers, such as a marker specific for tumor cells and a marker specific for immune cells, are disclosed. The differentiation between the tumor cells and immune cells may improve the ease of scoring, the accuracy and speed of scoring, and the reproducibility of scoring of pd-l1 positive samples for therapy purposes..
Ventana Medical Systems, Inc.


12/03/15
20150344910 

Methods for controlling stem cell differentiation


Disclosed herein are methods for controlling stem cell differentiation through the introduction of transgenes having xic, tsix, or xite sequences to block differentiation and the removal of the transgenes to allow differentiation. Also disclosed are small rna molecules and methods for using the small rna molecules to control stem cell differentiation.
The General Hospital Corporation


12/03/15
20150344878 

Compositions and methods for treatment of mitochondrial diseases and for differentiation of cells to neurons


Methods and compositions are provided for the treatment of a mitochondrial disease in an individual with the mitochondrial disease. Aspects of the methods include administering an inhibitor of a pumilio-like protein and/or an inhibitor of a serine/arginine-rich family of pre-mrna splicing factor (sr) protein to a subject.
The Board Of Trustees Of The Leland Stanford Junio R University


12/03/15
20150344106 

Vessel with a flow deflecting hydrodynamic bow fin arrangement


A vessel with a hydrodynamic duct of flow management at the bow thereof, said duct comprising a pair of lateral walls (2, 3) with an airfoil section on either side of the bow connected with a horizontally oriented or inclined wall portion (1) with an airfoil section, the duct being displaceable in the vertical direction between positions (a) and (b) and contributing in the reduction of wave making and frictional resistances through differentiation of the flow within from the flow outside the duct in cooperation with a bow having longitudinally extending rectilinear or convex side walls (102, 103). The lateral walls (2, 3) have their trailing edge at a constant distance from the side walls (102, 103) of the bow, whilst they might for aesthetic reasons comprise movable airfoil section coverings (2′, 3′) or internal sheet laminates (20′, 30′) which protrude outwardly during navigation of the vessel and retract inwardly when the vessel is stationery in a port destination..

12/03/15
20150343018 

Nod2-dependent pathway of cytoprotection of stem cells


The present invention is directed to an agonist of nod2 for use in therapy for increasing the autonomous capacity of survival of vertebrate adult stem cells, without loss of their capacity to multiply and differentiate, and preferably the capacity of survival of intestinal stem cells, especially in response to a stress. The invention also concerns the use of an agonist of nod2 for increasing in vitro or ex vivo the autonomous capacity of survival, without loss of multiplication and differentiation capacity of mammalian adult stem cell.
Institut Pasteur


12/03/15
20150342945 

Substituted quinoline compounds and methods of use


The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.


11/26/15
20150337025 

Use of fusion protein


Disclosed is the use of a fusion protein in drugs for stimulating differentiation of bone marrow mesenchymal stem cells to hematopoietic stem/progenitor cells, or drugs for proliferation of granulocyte hematopoietic progenitor cells. The fusion protein has a sequence as shown in seq id no: 2 or seq id no: 4.
East China University Of Science And Technology


11/26/15
20150336757 

Multi-feed detection device, and sheet-shaped-object handling device


A multi-feed detection device is provided with: a base; an arm rotatably supported on the base; a magnet affixed to the arm; a hall element which is affixed to the base, and which outputs an electric signal corresponding to the strength of the magnetic field; a differentiation circuit which outputs a voltage corresponding to the differential value of the output of the hall element; and an integration circuit which outputs a voltage corresponding to the integral value of the output of the differentiation circuit. The arm applies a force against a conveyance path by way of a spring.
Simotec Co., Ltd.


11/26/15
20150335678 

Method of activating stem cells in an animal and the use of chlorine dioxide for preparing medicines for activating stem cells in an animal


The present invention provides a method for activating proliferation, migration and differentiation of stem cells in an animal comprising the preparation of the activating agent, the step of administering to the animal an effective amount of chlorine dioxide and the use of the chlorine dioxide for activating proliferation, migration and differentiation of stem cells. The method of the invention, with a wide application range, can be used in the treatments which need the tissue regeneration and immunomodulatory capability of stem cells and to the activation of proliferation, migration and differentiation of stem cells in injured organs and/or tissues.

11/19/15
20150334733 

Data scheduling


Embodiments of the present invention disclose a data scheduling method and a data scheduling device, which is configured to: receive channel quality information sent by a first terminal; calculate a current instantaneous scheduling rate of the first terminal on a first component carrier by using the channel quality information; acquire an average scheduling rate of the first terminal on the first component carrier; calculate a scheduling priority of the first terminal on the first component carrier by using the instantaneous scheduling rate and the average scheduling rate; and allocate a physical resource of the first component carrier to the first terminal. In this way, a multi-carrier terminal is enabled to obtain a stable high rate, differentiation between terminals is achieved.
Huawei Technologies Co., Ltd.


11/19/15
20150334626 

Method of heterogeneous network mobility


Methods for enhanced heterogeneous network mobility are proposed. In a first novel aspect, the cell size of a target cell is considered when determining the ttt value.
Mediatek Inc.


11/19/15
20150330983 

Peptidic and non peptidic ligands for immunodetection of the receptor for urotensin ii


The use of opportunely modified specific ligands of the receptor for urotensin ii (utr) or antibodies (commercially available) raised against the same receptor as tools for the definition of both the differentiation and the prognosis of human prostate adenocarcinoma is described, moreover, the use of opportunely radiolabeled ligands for utr in the definition of the extension of disease is also described.. .

11/19/15
20150330493 

Driveline disconnect with modular rear driveline module (rdm) with integrated coupling and differential control


A motor vehicle powertrain (10, 210, 310) having a rear driveline module (rdm) (20) for driving a pair of rear wheels (14a, 14b) and a method of assembly can include a hydraulically actuatable rear axle coupling clutch (28) operable to transmit rotary power between an input pinion shaft (22, 222) and a rear differential case (30, 230) and a hydraulic actuating assembly (16). The powertrain (10, 210, 310) can include a hydraulically actuatable differential control clutch (34) mounted coaxial to the rear axle coupling clutch (28) and a power take-off unit (ptu) (36) having a hydraulically actuatable ptu coupling clutch (42).
Borgwarner Inc.


11/19/15
20150329908 

Pattern recognition receptor expression as a measure of systemic health


The present invention encompasses methods and kits employing pattern recognition receptor expression as a measure of systemic health in a subject afflicted with an oral health condition. In particular, the present invention is directed to methods involving measurement of the expression levels of one or more pattern recognition receptors including but not limited to toll like receptors, myeloid differentiation primary response gene 88 (myd88), and nucleotide binding oligomerization domain containing protein 1 (nod1), in a companion animal, e.g., a dog or a cat, afflicted with an oral health condition.
Hill's Pet Nutrition, Inc


11/19/15
20150329828 

Use of small molecules to enhance mafa expression in pancreatic endocrine cells


The present invention provides methods, cell cultures and differentiation media to promote differentiation of pluripotent stem cells to pancreatic endocrine cells of a mature phenotype. The resulting pancreatic endocrine cells express single hormonal insulin, pdx1, nkx6.1, and mafa.
Janssen Biotech, Inc.


11/19/15
20150329823 

Co-differentiation of monocytes from allogeneic donors


Disclosed is a method of producing non-exhausted immature dendritic cells (dcs) originating from at two different, allogeneic donors. In the method, a mixture of allogeneic leukocytes, which allogeneic leukocytes have been obtained from at least two different, allogeneic donors is provided.
Immunicum Ab


11/19/15
20150329821 

Methods of differentiating stem cells into one or more cell lineages


The present disclosure provides an understanding of the regulation of the developmental phases of stem cells and their induction into relevant cell lineages, such as primitive streak, endoderm, mesoderm, or subterrotories of endoderm's. In particular, the present disclosure provides methods, culture medium and kits for the maintenance and differentiation of stem cells into relevant cell lineages..
Agency For Science, Technology And Research


11/19/15
20150329554 

Compounds and compositions for inducing chondrogenesis


Or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds, and methods of using such compounds for treatment of joint damage or joint injury in a mammal, and for inducing differentiation of mesenchymal stem cells into chondrocytes..

11/19/15
20150328249 

Modulation of myofiber repair by anti-myostatin strategies and/or ppar gamma ligands, alone or in combination with stem cells, for the therapy of critical limb ischemia and other ischemic processes affecting the skeletal muscle


Treating or inhibiting an ischemic condition affecting the skeletal muscle comprising administering an agent having a property to inhibit an activity or a protein expression of myostatin or growth differentiation factor 8 (gdf-8) according to a regimen to treat or inhibit the ischemic condition. Treating or inhibiting an ischemic condition affecting the skeletal muscle including administering an effective amount of a thiazolidenedione or other ppar gamma agonist at a dosage that do not exert glycemic control or induce overweight.
Los Angeles Biomedical Research Institute At Harbor-ucla Medical Center


11/12/15
20150324978 

Aqueous cell differentiation in anterior uveitis using optical coherence tomography


Methods and systems for determining a percentage composition of aqueous cells in an anterior chamber of an eye of a subject based on cell reflectance distributions calculated from oct image data are disclosed. In one example approach, determining a percentage composition of detected aqueous cells may comprise calculating a percentage of the detected aqueous cells which are polymorphonuclear and calculating a percentage of detected aqueous cells which are mononuclear..
Oregon Health & Science University


11/12/15
20150324579 

Method, apparatus, and system for managing user accounts


Embodiments of the present application relate to a method and system for managing user accounts. The method includes receiving a registration request from a current user, wherein the registration request comprises a login name main part, determining, in a database, whether a conflicting old user exists, wherein a conflicting old user corresponds to another user that has a conflicting login name main part that is the same as the login name main part received in connection with the registration request, in the event that a conflicting old user exists, executing a login password differentiation process that requires a user to register a different login password that is different from a login password associated with the conflicting old user, and storing the different login password to the database in connection with a registration of the current user..
Alibaba Group Holding Limited




Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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