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This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS



Date/App# patent app List of recent Differentiation-related patents
08/27/15
20150244791 
 System and  delivering data that provides service differentiation and monetization in mobile data networks patent thumbnailSystem and delivering data that provides service differentiation and monetization in mobile data networks
An exemplary system according to the present disclosure comprises a lower tier radiolet™ that is in communication with a local switching office of a mobile data network, and an upper tier radiolet™ that is in communication with the lower tier radiolet™ and an internet datacenter. In operation, the upper tier radiolet™ receives data extracted from the internet datacenter and distributes at least a portion of the received data to the lower tier radiolet™.
Alef Mobitech Inc.


08/27/15
20150242558 
 Method and  direct self assembly in target design and production patent thumbnailMethod and direct self assembly in target design and production
Target designs methods and targets are provided, in which at least some of the differentiation between target elements and their background is carried out by segmenting either of them. Directed self-assembly (dsa) processes are used to generate fine segmentation, and various characteristics of the polymer lines and their guiding lines are used to differentiate target elements from their background.
Kla-tencor Corporation


08/27/15
20150240211 
 Media for culturing, preserving, and administering regenerative cells patent thumbnailMedia for culturing, preserving, and administering regenerative cells
A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a gag composition comprising a sulfated gag, such as chondroitin sulfate.
Arthrodynamic Technologies, Animal Health Division, Inc.


08/27/15
20150240206 
 Brown adipocyte progenitors in human skeletal muscle patent thumbnailBrown adipocyte progenitors in human skeletal muscle
This invention relates to brown adipose tissue (bat) progenitor cells and methods for isolating bat progenitor cells from skeletal muscle. Bat progenitor cell surface markers and medium and agents for inducing cell differentiation into brown adipocytes are also provided.
Energesis Pharmaceuticals, Inc.


08/27/15
20150240205 
 Conditionally immortalized long-term stem cells and methods of making and using such cells patent thumbnailConditionally immortalized long-term stem cells and methods of making and using such cells
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (aml) and cells and methods related to such mouse model are also described..
The Regents Of The University Of Colorado


08/27/15
20150239968 
 Monoclonal antibodies to growth and differentiation factor 15 (gdf-15) patent thumbnailMonoclonal antibodies to growth and differentiation factor 15 (gdf-15)
The present invention relates to novel monoclonal anti-human-gdf-15 antibodies, pharmaceutical compositions, kits, methods and uses and the cell lines capable of producing the monoclonal antibodies described herein. The present invention further relates to novel antibodies to human gdf-15 capable of inhibiting cancer growth..
Julius-maximilians-universitÄt WÜrzburg


08/27/15
20150238697 
 Syringes having tactile labeling elements patent thumbnailSyringes having tactile labeling elements
Syringes having various tactile and visual differentiation features are provided. Elements of differentiation ribs of various shapes and configurations are located on the syringe tube.
Andersen-michaud, Llc


08/27/15
20150238556 
 Neuritogenic peptides patent thumbnailNeuritogenic peptides
The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin..
Neoloch Aps


08/27/15
20150238531 
 Urine stem cells for skeletal muscle generation and uses thereof patent thumbnailUrine stem cells for skeletal muscle generation and uses thereof
Provided herein are methods of treating a subject in need of treatment for a urological condition including administering urine stem cells to said subject in a treatment effective amount; and, in conjunction therewith, administering growth factors to said subject in an amount effective to promote differentiation of said stem cells into skeletal muscle cells. Compositions useful for the same are also provided..
Wake Forest University Health Sciences


08/20/15
20150236688 
 Power-on reset circuit patent thumbnailPower-on reset circuit
A power-on reset circuit of one embodiment includes first and second power supplies, first and second detecting circuit, a differentiation circuit, a current mirror circuit and a latch circuit. The second power supply is generated from a voltage of the first power supply and supplies a voltage lower than the first power supply.
Kabushiki Kaisha Toshiba


08/20/15
20150234478 

Mobile device application state


Techniques for mobile device application state are described. In one or more implementations, a mobile device includes a computing device that is flexibly coupled to an input device via a flexible hinge.
Microsoft Technology Licensing, Llc


08/20/15
20150233921 

Detection of subject biomarker diagnostic assay for dengue fever and the differentiation of dengue hemorrhagic fever


Vitronectin is found to be a biomarker of progression from dengue fever to dengue hemorrhagic fever according to the present invention. Assay of vitronectin in biological samples of dengue virus infected subjects aids in prognosis, diagnosis and treatment of the disease, particularly in prediction of progression from dengue fever to severe dengue i.e.
The Government Of The United States Of America As Represented By The Secretary Of The Department Of


08/20/15
20150232826 

Pharmaceutical composition containing core factor involved in proliferation and differentiation of central nervous cell


With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) crbn, 2) a nucleic acid encoding crbn, or 3) a stem cell or a neural progenitor cell in which crbn is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using crbn, are provided.. .
Celgene Corporation


08/20/15
20150232536 

Igg stimulated remyelination of peripheral nerves


The present invention is based on the discovery of polyclonal igg's ability to promote schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal igg are provided.
Baxter Healthcare Sa


08/20/15
20150232522 

Brown adipocyte differentiation-inducing agent


The present invention addresses the problem of providing a means which is effective for the induction of the differentiation of a brown adipocyte and therefore enables a brown adipocyte to be used for and applied to, for example, the prevention/treatment of obesity or metabolic syndrome. Provided is a brown adipocyte differentiation-inducing agent containing, as an active ingredient, (1) creg1 protein or (2) an expression vector carrying creg1 gene..
Chubu University Educational Foundation


08/13/15
20150229970 

Methods and systems for packet differentiation


Methods and systems are disclosed facilitate differentiated qos service for packets within a single packet stream. For example, extended qci values may be used to differentiate service of video packets associated with different priorities.
Vid Scale, Inc.


08/13/15
20150225698 

In vitro pancreatic differentiation of pluripotent mammalian cells


This invention relates to the in vitro differentiation of pluripotent cells into pancreatic progenitors by i) culturing pluripotent cells in a definitive endoderm (de) medium comprising a tgfp ligand, fibroblast growth factor (fgf), bone morphogenetic protein (bmp), a pi3k inhibitor and optionally a gsk3 β inhibitor to produce a population of definitive endoderm cells, ii) culturing the definitive endoderm cells in a first pancreatic medium comprising an activin antagonist; fgf; retinoic acid; and a bmp inhibitor to produce a population of dorsal foregut cells; iii) culturing the dorsal foregut cells in a second pancreatic medium comprising fgf, retinoic acid, a bmp inhibitor, and a hedgehog signalling inhibitor, and; iv) culturing the endoderm cells in a third pancreatic medium comprising fgf. The progenitor cells thus produced may be further differentiated into pancreatic endocrine cells.
Cambridge Enterprise Limited


08/13/15
20150225697 

Natural killer cells and uses thereof


Provided herein are methods of producing natural killer (nk) cells and nk progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of nk cells and nk progenitor cell populations using a three-step expansion and differentiation method.
Anthrogenesis Corporation


08/13/15
20150224169 

Compounds and methods for selectively targeting cancer stem cells


Described are compounds and methods useful for selectively targeting cancer stem cells. The compounds preferentially induce differentiation and/or reduce the proliferation of cancer stem cells relative to normal stem cells.
Mcmaster University


08/13/15
20150224152 

Methods for modulating bacterial infection


The present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria. More particularly, the present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria of the gastrointestinal (gi) tract.

08/06/15
20150221216 

Differentiation of probe reports based on quality


Methods for differentiating high quality probe reports in a plurality of probe reports include: (a) receiving, by a processor, a probe report from a probe source, wherein the probe report includes data indicative of a travel condition; (b) determining, by the processor, whether the probe report satisfies a criterion indicative of high quality data; and (c) identifying, by the processor, the probe report as being (i) suitable for use in modeling the travel condition if the probe report satisfies the criterion, or (ii) unsuitable for use in modeling the travel condition if the probe report does not satisfy the criterion. Systems for differentiating high quality probe reports in a plurality of probe reports are described..
Here Global B.v.


08/06/15
20150220463 

Prioritizing storage operation requests utilizing data attributes


Storage operation requests from any device of a computing environment can be numerous and frequent. In particular, if there is a high frequency initiation of storage operation requests to store, retrieve, or modify data, then targeted storage systems have to easily and quickly decide in which order to satisfy the storage operation requests, such as when two requests occur to retrieve identical data.
International Business Machines Corporation


08/06/15
20150219728 

Method and device for measuring various parameters of membrane electrode assembly in fuel cell


A method and a device for measuring various parameters of a membrane electrode assembly (mea) in a fuel cell. Hydrogen gas and nitrogen gas or air are supplied to the fuel cell to be tested.
Tsinghua University


08/06/15
20150219627 

Compendium of ready-built stem cell models for interrogation of biological response


The invention generally features methods for providing engineered pluripotent stem cells that can be used to study biological response and pathways, including differentiation and drug effects. For example, these cells are provided comprising two or more exogenous expression cassettes including a selectable or screenable marker under the control of different condition-responsive regulatory elements, such as differentiation-responsive promoters or regulatory element of a receptor, drug target, drug metabolizing enzyme or signaling pathway gene.
Cellular Dynamics International, Inc.


08/06/15
20150219543 

Cell evaluation method


The present invention relates to a cell evaluation method comprising evaluating a cell differentiation degree based on a cell thickness.. .
Kyoto University


08/06/15
20150219510 

Dynamometer system control device


Provided is a dynamometer system control device capable of stable and highly responsive control. This dynamometer system control device is provided with a torque control device which outputs a torque command signal on the basis of an output signal (lc_det) of a load cell, and with a characteristic vibration suppression circuit which corrects the torque command signal to suppress the characteristic vibration of an oscillator and which inputs said signal to an inverter as a control input signal.
Meidensha Corporation


08/06/15
20150218514 

Promoter of differentiation from hepatic progenitor cell into hepatic cell, and use thereof


The present invention provides a promoter of differentiation from a hepatic progenitor cell into a hepatocyte, which contains a substance that suppresses expression of dnmt-1 or a substance that inhibits the function of dnmt-1 as an active ingredient, and a method of producing a hepatocyte (preferably hepatocyte with high maturity) from a hepatic progenitor cell.. .
Ds Pharma Biomedical Co., Ltd.


08/06/15
20150218510 

Electroactive scaffold


A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material.
U.s.a. As Represented By The Administrator Of The National Aeronautics And Space Administration


08/06/15
20150216935 

Autologous cell-based therapy for treating obesity


Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ascs) to a site in the body of a subject.
Brown University


08/06/15
20150216429 

Non-contrast mri with differentiation of ischemic, infarct and normal tissue


Elicited mri signals are processed into mr image data in conjunction (a) with use of an initial spatially-selective rf tag pulse (tag-on) and (b) without use of an initial spatially-selective nmr rf tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (ti) intervals without using an injected contrast agent.
Toshiba Medical Systems Corporation


07/30/15
20150212227 

Downhole differentiation of light oil and oil-based filtrates by nmr with oleophilic nanoparticles


Downhole nuclear magnetic resonance (nmr) methods that utilize oleophilic nanoparticle may allow for differentiation of light oil and oil-based filtrates. For example, a method may involve drilling a wellbore penetrating a subterranean formation using an oil-based drilling fluid that comprises an oil base fluid and a plurality of oleophilic nanoparticles; performing a plurality of nmr measurements at a plurality of depths of investigation (doi) of a near-wellbore portion of the subterranean formation; and producing an invasion profile of an oil-based drilling fluid filtrate into the near-wellbore portion of the subterranean formation based on the plurality of nmr measurements..
Halliburton Energy Services, Inc.


07/23/15
20150204870 

Undifferentiated cell detection method and complex carbohydrate detection method


An object of the present invention is to provide a method for evaluating a differentiation status of cells using a culture supernatant of stem cells. Provided is “undifferentiation sugar chain marker” composed of the sugar chain structure “fucα1-2galβ1-3glcnac” or “fucα1-2galβ1-3galnac” and capable of sensitively determining the undifferentiated state of stem cells using a culture supernatant of stem cells.
Wako Pure Chemical Industries, Ltd.


07/23/15
20150203846 

Treatment of myelodysplastic syndrome by inhibition of nr2f6


Methods, compositions, and treatment protocols are provided in the current invention for the treatment of myelodysplastic syndrome (mds) through the inhibition of nr2f6 gene expression or activity of protein. In one embodiment silencing, or substantial inhibition of nr2f6 expression is achieved through induction of rna interference in cells associated with development of mds.

07/23/15
20150203822 

Method and device for preparing non-embryonic stem cells


The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, which has a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from such tissue derivative, wherein the tissue derivative or such cells are subjected to vibrations derived from a heart sound to control the degree of differentiation or possible differentiation of the stem and multipotent elements into several other types of cells and optimize their potency. The invention relates also to a device for carrying out the process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue..
Lipogems International Srl


07/23/15
20150203818 

Erythroid production


This invention provides method and media suitable for inducing and supporting the differentiation of stem cells into erythroid cells.. .
University Court Of The University Of Glasgow


07/23/15
20150203809 

Cell culture


The disclosure relates to the fabrication of a three dimensional [3-d] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells.. .
Centre National De La Recherche Scientifique


07/23/15
20150202256 

Differentiation marker and differentiation control of eye cell


The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising gpr49/lgr5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to gpr49/lgr5.
The Doshisha


07/23/15
20150202234 

Injectable brown adipose microtissues for treatment and prevention of obesity and diabetes


Provided are methods, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes by administration of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues to a subject, where the microtissues comprise adipose stem cells and endothelial cells. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3d cell aggregates..
The Trustees Of Columbia University In The City Of New York


07/16/15
20150197726 

Compounds for improved stem cell differentiation into hepatocytes


The invention relates to the compounds of formula i and pharmaceutically acceptable salts and esters thereof, wherein r1-r11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula i as well as pharmaceutical compositions containing such compounds.
Hoffmann-la Roche Inc.


07/16/15
20150196604 

Agent for treating urinary incontinence including stem cells derived from amniotic fluid


The present invention relates to a cell therapy product which is intended for regenerating a sphincter muscle and which contains stem cells derived from amniotic fluid, and more particularly, to a cell therapy product which is intended for regenerating the sphincter vesicae and which contains stem cells derived from amniotic fluid. Also, the cell therapy product of the present invention can be provided in the form of a formulation for administration through injection, said formulation being injected into a hydrogel complex to thereby improve the effects thereof.
Kyungpook National University Hospital


07/09/15
20150192568 

Method and determining degree of stratification and/or differentiation


A method for easily and non-invasively determining a degree of stratification and/or differentiation of cultured cells, and an apparatus for determining a degree of stratification and/or differentiation of cultured cells are provided. The invention relates to a method for determining a degree of stratification and/or differentiation of cultured cells, including: (a) a harvesting step of harvesting a culture solution of the cultured cells; (b) an analytical step of analyzing at least one type of a metabolite of the pentose phosphate pathway and/or the tca cycle in the culture solution; and (c) a determination step of referring to a database of correlations between prospectively-obtained degrees of stratification and/or differentiation of the cultured cells and analytical results of metabolites, for analytical results obtained in the analytical step, to determine the degree of stratification and/or differentiation of the cultured cells..
Hitachi, Ltd.


07/09/15
20150191744 

Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling


The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal crispr/cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state..
University Of Massachusetts


07/09/15
20150191700 

Differentiation of human embryonic stem cells


The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage..
Janssen Biotech, Inc.


07/09/15
20150191699 

Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof


The disclosure provided herein relates generally to mesenchymal-like stem cells “hes-t-misc” or “t-msc” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblasts to hes-t-msc or t-msc, t-msc derived cells and cell lineages “t-msc-dl” are also described.
Imstem Biotechnology, Inc.


07/09/15
20150191698 

Adipose-derived stem cells and lattices


The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells.
University Of Pittsburgh Of The Commonwealth System Of Higher Education


07/09/15
20150191697 

Cardiomyocyte production


Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of rock inhibitors are described.
Cellular Dynamics International, Inc.


07/09/15
20150191695 

Composition including gelsolin as effective ingredient for inducing differentiation into dendritic cell and inducing differentiation into dendritic cell


Disclosed are a composition including gelsolin as an effective ingredient for inducing differentiation into a dendritic cell, a method of inducing differentiation by using the composition, and a vaccine composition for treating cancer or an immune-mediated disease. In addition, a composition including gelsolin as an effective ingredient for inducing differentiation into a dendritic cell and a method of inducing differentiation into a dendritic cell by treating an immature dendritic cell with gelsolin are also disclosed.
Korea Institute Of Radiological & Medical Services


07/09/15
20150190547 

Bone matrix compositions and methods


An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier.
Warsaw Orthopedic, Inc.


07/09/15
20150190503 

Methods of using ceo2 and tio2 nanoparticles in modulation of the immune system


Redox-active nps are disclosed that can potentiate innate immunity and stimulate distinct adaptive responses, producing distinct t cell subset polarization outcomes. Nanomaterials that can alter the cellular redox environment through ros modulation can impact human immunology.
Sanofi Pasteur Vaxdesign Corp.


07/09/15
20150190452 

Use of kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function


The present invention relates to a pharmaceutical composition containing kaempferia parviflora wall. Ex.
Industry-academic Cooperation Foundation, Yonsei University


07/02/15
20150188467 

Zero crossing point estimating circuit, motor driving control apparatus and method using the same


A motor driving control apparatus may include: back-electromotive force detecting unit detecting back-electromotive force generated by a motor apparatus; a zero crossing point estimating unit estimating a zero crossing point by performing at least one of differentiation and integration on a voltage difference between the back-electromotive force and a preset reference voltage; and a controlling unit controlling phase switching of the motor apparatus using the zero crossing point.. .
Samsung Electro-mechanics Co., Ltd.


07/02/15
20150186606 

Method and device for indicating differentiation between tissues


The present invention provides a method for indicating differentiation between tissues. For each tissue amongst multiple tissues, a magnetization vector corresponding to each tissue is generated on the basis of a random scan sequence; on the basis of the magnetization vector corresponding to each of the multiple tissues, a differentiation-indicating value between each pair of the multiple tissues is calculated.
Siemens Aktiengesellschaft


06/25/15
20150178307 

Data deduplication using crc-seed differentiation between data and stubs


Various embodiments for differentiating between data and stubs pointing to a parent copy of deduplicated data. Undeduplicated data is stored with a checksum of an initial value.
International Business Machines Corporation


06/25/15
20150175964 

Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells


The invention relates to the field of cell culture, specifically, the derivation of retinal pigmented epithelial cells from pluripotent cells. The invention comprises the use of various cell culture medium supplements, medium formulations, and methods of using such medium supplements and formulations, in order to effect the rapid differentiation of pluripotent cells into retinal pigmented epithelial cells with very high yields.
The Regents Of The University Of California


06/25/15
20150175962 

Generating hepatocytes


Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein..
The Regents Of The University Of California


06/25/15
20150175961 

System and method to facilitate the growth of stem cells


A method and system to maintain adult or embryonic stem cells employing 3-d culture conditions is disclosed. Hydrogel scaffolds, composed of hydrophilic polymer networks are provided to emulate a fully hydrated native extracellular matrix and natural soft tissue.
Oakland University


06/25/15
20150175699 

Humanized antibodies to cluster of differentiation 3 (cd3)


Humanized monoclonal antibodies (mabs) or fragments thereof, to human cluster of differentiation 3 (cd3), which confer improved immune stimulation and stability, are disclosed. Pharmaceutical compositions comprising said mabs and methods of treatment and optionally also prevention of diseases and disorders, such as autoimmune disorders, infectious diseases, and transplant rejection, that are susceptible to amelioration by binding to cd3, are also disclosed..
Therapix Biosciences Ltd.


06/18/15
20150170875 

Charged particle beam apparatus


The present invention relates to a defect inspection apparatus based on the fact that contrasts of a grain and a void of a semiconductor copper interconnect in a scanning electron microscope are changed depending on electron beam irradiation accelerating voltages. A charged particle beam apparatus of the present invention irradiates the same portion of a specimen with electron beams at a plurality of accelerating voltages, and differentiates a grain (65, 66) from a void (67) on the basis of a contrast change amount of the same portion in a plurality of images (61, 62) acquired so as to respectively correspond to the plurality of accelerating voltages.
Hitachi High-technologies Corporation


06/18/15
20150169493 

Field unit and a operating an automation system


A field unit with a bus node which is designed for signal conversion between an external bus protocol and an internal bus protocol for communication with at least one function module, in such a way that a sequential transmission of data packets is made along an internal bus system and also including function modules which are designed for processing of data packets and for signal transmission with at least one downstream function component wherein the bus node is so designed for a differentiation of data packets of the higher-level control device that in the bus node a processing of non-safety-related data packets to the internal bus system and onwards transmission of safety-related data packets to the internal bus system is effected, and wherein at least one function module connected to the internal bus system is designed as a safety module for processing of safety-related data packets.. .
Festo Ag & Co. Kg


06/18/15
20150167080 

Method of determining clonotypes and clonotype profiles


The invention is directed to methods for determining clonotypes and clonotype profiles in assays for analyzing immune repertoires by high throughput nucleic acid sequencing of somatically recombined immune molecules. In one aspect, the invention comprises generating a clonotype profile from an individual by generating sequence reads from a sample of recombined immune molecules; forming from the sequence reads a sequence tree representing candidate clonotypes each having a frequency; coalescing with a highest frequency candidate clonotype any lesser frequency candidate clonotypes whenever such lesser frequency is below a predetermined value and whenever a sequence difference therebetween is below a predetermined value to form a clonotype.
Sequenta, Inc.


06/18/15
20150166961 

Ex vivo expansion of myogenic stem cells by notch activation


Activating notch signaling in cultured canine muscle derived cells inhibited myogenic differentiation, and increased the number of myogenic progenitor cells that were similar to quiescent or newly activated satellite cells. Importantly, cells expanded in the presence of notch activation maintained engraftment potential, indicating the potential for therapeutic benefit.
Fred Hutchinson Cancer Research Center


06/18/15
20150166950 

Pluripotent stem cell culture on micro-carriers


The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on micro-carriers.. .
Janssen Biotech, Inc.


06/18/15
20150166661 

Anti-cd3 antibodies and methods of use


The invention provides anti-cluster of differentiation 3 (cd3) antibodies and methods of using the same.. .
Genentech, Inc.


06/18/15
20150165203 

Methods of and devices for chemical and threshold-gated electrical neuro-immuno-stimulation that triggers the stem cell growth to restore bodily functions


A method of reducing pain and induce/enhance the stem cell growth/differentiation reaction includes identifying a pair of related noxipoints on an identified muscle/organ and applying a chemical/electrical stimulation to the pair of noxipoints.. .

06/18/15
20150164991 

Method and kit for evaluating and monitoring a treatment program for anemia


The present disclosure relates to methods and kits for evaluating and/or monitoring a treatment program, such as in an anemic subject or in a subject receiving treatment for anemia, including determining a presence or an amount of growth differentiation factor 15 (gdf15) and/or hepcidin in a biological sample from the subject. Further, in some embodiments, the disclosure provides methods and/or kits for treating a disorder of iron homeostasis in a subject, comprising measuring an amount of gdf15 and/or an amount of hepcidin in a sample from a subject and administering iron and/or erythropoietin (epo) to the subject if there is a measurable difference in the amount of gdf15 and/or hepcidin in the sample as compared to a reference amount..
Vanderbilt University


06/18/15
20150164987 

Wnt signaling inhibitor comprising insulin-like growth factor-binding protein


Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of wnt signalling, comprising an insulin-like growth-factor-binding protein (igfbp), the protein being binding to a wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced wnt signalling, comprising the inhibitor of wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof..
National University Corporation Chiba University


06/11/15
20150161307 

Method of designing semiconductor device, designing assistance program, designing apparatus, and semiconductor device


The present invention provides a method of designing a semiconductor device capable of executing a dvfs control which minimizes consumption energy. A consumption power profile p(t) when a known operating voltage and a clock of a known frequency are given to a logic circuit as a dvfs target and a process as a dvfs target is executed is obtained.
Renesas Electronics Corporation


06/11/15
20150159140 

Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells


The present invention prepared insulin-producing endocrine cells by inducing the differentiation of human embryonic stem cells or human induced pluripotent stem cells into definitive endoderm (de), pancreatic endoderm (pe), endocrine progenitors (ep), and endocrine cells (ec) stepwise in that order. Particularly, the present invention established the conditions for the formation of an insulin producing endocrine aggregate (ea) from the endocrine cells.
Korea Advanced Institute Of Science And Technology


06/11/15
20150159139 

Differentiation of human embryonic stem cells


The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells.
Lifescan, Inc.


06/11/15
20150159137 

Adjuvant for rapid proliferation of human mesenchymal stem cells in vitro, rapid proliferation of human mesenchymal stem cells in vitro, growth factor harvested from rapid proliferation of human mesenchymal stem cells in vitro and use thereof


An adjuvant for rapid proliferation of human mesenchymal stem cells in vitro is provided to overcome the problem of low cell amplification efficiency of human mesenchymal stem cells in a culture process. The adjuvant added for the culture of human mesenchymal stem cells includes at least one antioxidant, and a basic fibroblast growth factor (fgf-2).
Buddhist Tzu Chi Medical Foundation


06/11/15
20150159133 

Method of in vitro differentiation of motor neuron progenitors (mnps) from human induced pluripotent stem cells and cryopreservation of mnps


Methods are disclosed for the initiation and differentiation of human embryonic stem cells (hescs) and induced pluripotent stem cells (ipscs) into motor neuron progenitor cells (mnps). Methods are also disclosed for the cryopreservation of mnps.
Lonza Walkersville, Inc.


06/11/15
20150159132 

Technology for cell transdifferentiation


This invention provides technology for transdifferentiating cells from one cell type to another. The cells are cultured with one or more vector-free gene regulator oligonucleotides concurrently or in succession, and then harvested when cell markers or the morphology of the culture shows that transdifferentiation is complete.
Fluidigm Corporation


06/11/15
20150159131 

Methods and compositions for regulating musashi function


The invention generally features compositions and methods for detecting and regulating cell proliferation, potentiation, and differentiation in a population of cells. In particular, compositions and methods are provided for modulating the activity of musashi proteins.
Board Of Trustees Of The University Of Arkansas


06/11/15
20150158840 

Compounds for improved stem cell differentiation into hepatocytes


The invention relates to the compounds of formula i and pharmaceutically acceptable salts and esters thereof, wherein r1-r11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula i as well as pharmaceutical compositions containing such compounds.
Hoffmann-la Roche Inc.


06/11/15
20150157675 

Composition comprising eupatorium spp. extract as active ingredient for preventing and treating obesity and metabolic bone disease


The present invention relates to a eupatorium spp. Extract having anti-obesity effects as a result of decreasing adipocytes and increasing osteoblasts, as well as the effects of preventing bone disease or fractures by increasing osteoblasts and of preventing osteoporosis by decreasing adipocytes and increasing osteoblasts by the same proportion in mesenchymal stem cells.
Republic Of Korea (management:rural Development Administration)


06/11/15
20150157663 

Pharmaceutical composition comprising human-blood-derived-cell mass


There are provided a pharmaceutical composition for treating immune-related diseases, a pharmaceutical composition for treating ischemic diseases, a pharmaceutical composition for promoting lymphangiogenesis, a pharmaceutical composition for treating neurological diseases, a pharmaceutical composition for treating metabolic diseases, and the like, which contain blood-born hematospheres, and more specifically, may differentiate into inflammatory mononuclear cells, vascular endothelial cells, vascular smooth muscle cells, lymphatic vessel adult stem cells and progenitor cells, neural progenitor cells and nerve cells, insulin secreting cells, and the like by effective 3d culturing using blood mononuclear cells. Therefore, the present invention is expected to be used for development of a cell therapeutic agent for various types of diseases.
Snu R&db Foundation


06/04/15
20150153324 

Non-invasive measuring proliferation and differentiation state of cells by using magnetic resonance spectroscopy, and cell proliferation and differentiation marker for magnetic resonance spectroscopy used therefor


Provided are a noninvasive measurement of cell signals and a method thereof, wherein the measurement method can ascertain cell proliferation and differentiation states using mrs and can enable cells to be reused so that cell states can be evaluated with improved reproducibility and reliability. And since the cell signals are noninvasively measured using the mrs, the corresponding cells can be reused so that the cost and time needed for one experiment can be remarkably reduced..
Inje University Industry-academic Cooperation Foundation


06/04/15
20150152176 

Antagonist antibodies against gdf-8


The disclosure provides novel molecules related to growth and differentiation factor-8 (gdf-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit gdf-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (als).
Wyeth Llc


06/04/15
20150150983 

Intra-articular formulations and methods for treatment of osteoarthritis


Intra-articular formulations and methods are provided for treating joint conditions, such as osteoarthritis. The formulations include an effective amount of recombinant human growth differentiation factor-5 (rhgdf-5) and an acidic vehicle, where the formulation is an intra-articular injection formulation.
Depuy Mitek, Llc


06/04/15
20150150951 

Pharmaceutical composition comprising bee venom-phospholipase a2 (bv-pla2) for treating or preventing diseases related to degradation of abnormal regulatory t cell activity


The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory t cell activity comprising a polypeptide comprising a bee venom-pla2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase a2 of the present invention activates a regulatory t cell and suppress a differentiation of th1/th7.

06/04/15
20150150681 

Tissue repair devices and scaffolds


The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell.

05/28/15
20150150123 

Coordinated detection and differentiation of denial of service attacks


According to one embodiment, an analyzer module (am) within a same protected network and on-premise with a web application server (was) detects and distinguishes between types of denial-of-service (dos) attacks. The am tracks whether test http messages, which include test http request messages that a signal generation module (sgm) is configured to transmit to the was and test http response messages that the was is expected to transmit in response to the test http request messages, are timely received.
Imperva, Inc.


05/28/15
20150149106 

Field triage of eos failures in semiconductor devices


Automated test procedures, carried out under software control, can be employed to test a device, testing individual pins, and/or groups of pins, to detect and diagnose or characterize various types of failures. A distributed fa system includes a shared database for device definitions, test setups, and test results.
Teseda Corporation


05/28/15
20150148356 

Compounds for dry skin and anti-ageing application


The present invention relates to the cosmetic use, as agent for preventing and/or treating an aesthetic defect in the skin and/or its appendages that is associated with an imbalance in the differentiation and/or proliferation of the cells of an epidermis, of an effective amount of at least one compound represented by one of the general formulae, (ia) or (ib). .
L'oreal




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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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