|| List of recent Differentiation-related patents
|Apparatuses, systems, and methods for differentiation of payload size for d2d discovery|
Wireless mobile devices or user equipments (ues) may communicate directly with other ues, e.g., using device-to-device (“d2d”) direct discovery and communication. D2d direct discovery and communication may be used, for example, when ues communicate with each other while within direct wireless range of each other.
Intel Ip Corporation
|Method and arrangement for admission control based on priority level based differentiation|
The invention relates to a network node and a method therein for admission control in a wireless communication system. The method comprises receiving a request for a bearer setup from a requesting entity, where the request and/or bearer is associated with a priority level p.
Telefonaktiebolaget L M Ericsson (publ)
|Method, apparatus and system for detecting network element load imbalance|
Disclosed are a method, apparatus and system for detecting network element (ne) load imbalance, the method comprising the following steps: according to a preset detection policy, performing differentiation analysis for the ne performance index reported by every ne device, and storing the analysis results to the network index buffer pool; obtaining periodically the differentiation analysis results from the network index buffer pool, and determining whether there is a load imbalance anomaly among ne devices; when an anomaly is found, sending an alarm message. By using the techniques of load average value differentiation computing, load differentiation percent computing and threshold comparison, the present invention can detect in a timely manner load imbalance problems among ne devices in scenarios in which multiple ne devices are managed together, thereby enabling, by sending a1ann message at once, users to be notified to eliminate possible hidden safety risks, and thus improving the reliability, maintainability and stability of network communication devices..
|Finfet drive strength modification|
One application of this approach is to enable differentiation of the drive strengths of transistors in an integrated circuit by applying the technique to some, but not all, of the transistors in the integrated circuit. In particular in a sram cell formed from finfet transistors the application of the technique to the pass-gate transistors, which leads to a reduction of the drive strength of the pass-gate transistors relative to the drive strength of the pull-up and pull-down transistors, results in improved sram cell performance..
|Biomarkers in the selection of therapy of heart failure|
The present invention relates to a method for identifying a subject being eligible to the administration of at least one medicament selected from the group consisting of a beta blocker, an aldosterone antagonist, a diuretic, and an inhibitor of the renin-angiotensin system. The method is based on the determination of the amount of at least one biomarker selected from the group consisting of gdf-15 (growth differentiation factor 15), endostatin, mimecan, igfbp7 (igf binding protein 7), a cardiac troponin, a bnp-type peptide, uric acid, gal3 (galectin-3), osteopontin, sst2 (soluble st2), plgf, sflt-1, p1np, cystatin c, prealbumin, and transferrin in a sample from a subject suffering from heart failure.
Roche Diagnostics Operations, Inc.
|Cells exhibiting neuronal progenitor cell characteristics and methods of making them|
Disclosed are cells exhibiting neuronal progenitor cell characteristics, and methods of making them from marrow adherent stem cells by regulating cellular pathways in the marrow adherent stem cells that are associated with glial transdifferentiation of the marrow adherent stem cells.. .
|Cellular test systems for the determination of the biological activities of neurotoxin polypeptides|
The present invention pertains to a method for the generation of neurotoxin-sensitive, neuronal differentiated cells comprising the steps of: a) cultivating tumor cells which are able to differentiate into neuronal cells in a culture medium under conditions and for a time which primes said tumor cells for neuronal differentiation; and b) cultivating the tumor cells primed for neuronal differentiation of a) in a differentiation medium having an osmolality of 100 to 270 mosm/kg, and comprising (i) b27 supplement and/or (ii) n2 supplement, for at least 3 days, thereby obtaining neurotoxin-sensitive, neuronal differentiated cells. The invention further relates to neurotoxin-sensitive, neuronal differentiated cells obtainable by the method of the invention.
Merz Pharma Gmbh & Co. Kgaa
|Method for generating primate trophoblasts|
The first method to cause a culture of human and other primate stem cells to directly and uniformly differentiate into a committed cell lineage is disclosed. Treatment of primate stem cells with a single protein trophoblast induction factor causes the cells to transform into human trophoblast cells, the precursor cells of the placenta.
|Methods for treating anemia|
Provided herein are methods for the treatment of anemia, wherein the methods comprise administration of antagonists of growth differentiation factor 11 (gdf1 1; also known as bone morphogenetic protein 11 (bmp11)) to a subject in need of the treatment.. .
|Facile methods for fabricating a uniformly patterned and porous nanofibrous scaffold|
This invention describes a modified electrospinning method for making uniformly patterned and porous nanofibrous scaffolds that can be utilized in a variety of applications. While traditional electrospinning method uses a foil collector that generates compact layers of nanofibrous structures, resulting on the superficial cell growth and differentiation, the present method comprises adopting additional patterned film(s) on top of the conventional collector to make a patterned porous structure of nanofibrous scaffolds that are capable of supporting cell growth.
Cas In Bio Co., Lid.
Method for suppressing adipocyte formation
Provided are a naturally-derived agent for suppressing differentiation into adipocyte, readily available and ingestible in daily dietary life and having little side effects, a method for suppressing differentiation into adipocyte in a subject in need thereof, and the like. The present inventors have confirmed that a water extract of sargassum horneri has the effect of suppressing differentiation from bone marrow mesenchymal stem cell into adipocyte, thereby accomplishing the present invention..
Maruhachi Muramatsu, Inc.
Production of midbrain dopaminergic neurons and methods for the use thereof
Methods are provided for efficient production of midbrain dopaminergic (da) neurons. In some aspects, methods involve differentiation and selection of da neurons for a transgenic pluripotent cell population (e.g., cells comprising a selectable marker gene).
Cellular Dynamics International, Inc.
Automated wireless device provisioning and authentication
Automated provisioning and/or authentication of a device to a wireless access point is contemplated. The automated provisioning may be performed in a manner that enables the device to receive provisioning instructions in accordance with hotspot 2.0, passpoint or other wi-fi related protocols and standards without having to input identification or other user-specific information like a username and password combination.
Cable Television Laboratories, Inc.
Cluster of differentiation 36 (cd36) as a therapeutic target for hiv infection
The present invention concerns new methods for treating hiv infection by using cd36 inhibitors, antibodies or conjugates, and methods for identifying new molecules of interest for treating hiv infection.. .
Inserm (institut National De La Sante Et De La Recherche Medicale)
Compositions, methods and systems for cellular differentiation from stem cells
The present invention is directed to methods and systems directed to altering the differentiation of a cell, more particularly to biasing a potent cell, such as a mesenchymal stem cell, by contacting such cell with a protein having properties of bone morphogenic protein-4. The contacting may be achieved via genetic modification, and the resulting cell may be or have characteristics of a pre-adipocyte.
University Of Central Florida Research Foundation, Inc.
Dementia differentiation device
A leg movement acquisition unit 1 continuously acquires leg movements of a sleeping subject. An apnea detection unit 2 detects whether or not the subject is in a state of apnea.
The University Of Tokyo
Systems and methods for implementing reflective eps bearers to ensure uplink quality of service
The present disclosure is directed at systems, methods and media for providing qos differentiation between ip data flows by sorting data packets into bearers. If a first node in a communication network (e.g., a user equipment or ue) determines that downlink packets received from a second node (e.g., a packet data network gateway or pdn-gw) via a specific bearer should be given reflective bearer treatment, the first node can be configured to send uplink packets back to the second node via the same bearer.
Cisco Technology, Inc.
Biomarkers in peripheral blood mononuclear cells for diagnosing or detecting lung cancers
Methods and compositions are provided for diagnosing or detecting a condition, e.g., lung disease in a mammalian subject by use of a micro-rna expression level or an expression level profile of multiple mirna in the peripheral blood mononuclear cells (pbmc) of the subject which is characteristic of copd or nsclc. Detection of changes in expression in specific mirna biomarkers from that of a reference sample or mirna expression profile are correlated with non-small cell lung cancer (nsclc) and/or copd and permit differentiation among healthy subjects, subjects with copd and subjects with adenocarcinoma or squamous cell carcinoma..
The Wistar Institute Of Anatomy And Biology
Method of determining clonotypes and clonotype profiles
The invention is directed so methods for determining clonotypes and clonotype profiles in assays for analyzing immune repertoires by high throughput nucleic acid sequencing of somatically recombined immune molecules. In one aspect the invention comprises generating a clonotype profile from an individual by generating sequence reads from a sample of recombined immune molecules; forming from the sequence reads a sequence free representing candidate clonotypes each having a frequency; coalescing with a highest frequency candidate clonotype any lesser frequency candidate clonotypes whenever such lesser frequency is below a predetermined value and whenever a sequence difference therebetween is below a predetermined value to form a clonotype.
Adaptive Biotechnologies Corporation
Methods and kits useful in the differentiation of burkholderia species
The invention pertains to sequences, methods, and kits useful in the identification of and differentiation between burkholderia pseudomallei and burkholderia mallei. The methods generally involve the addition of oligonucleotides to mixtures containing nucleic acid isolated from a sample and performing nucleic acid amplification on the mixture..
Translational Genomics Research Institute
Differentiation of human embryonic stem cells
The present invention provides methods to promote the differentiation of pluripotent stem cells and the products related to or resulting from such methods. In particular, the present invention provides an improved method for the formation of pancreatic hormone expressing cells and pancreatic hormone secreting cells.
Regionalised endoderm cells and uses thereof
The present invention relates to the generation of anterior definitive endoderm (ade) cells from embryonic stem cells and the differentiation of such cells to, for example, pancreatic or liver cells. The invention also relates to cell lines, cell culture methods, cell markers and the like and their potential uses in a variety of applications..
The University Court Of The University Of Edinburgh
Synthetically designed extracellular microenvironment
The present invention provides for a biochemically and physically defined extracellular microenvironment prepared from mussel adhesive proteins recombinantly functionalized with a variety of bioactive peptides such as extracellular matrix-derived or growth factor-derived peptides. The synthetic extracellular microenvironment can be customized to regulate cellular behavior such as cell adhesion, growth, differentiation and morphogenesis in a variety of cells.
Kollodisbioscience, Co., Ltd.
Modulation of monocytes, or precursors thereof, differentiation
The invention is generally directed to promoting dendritic cells (dcs), and optionally m1-type (macrophage m1 polarization), immune response by administering a compound that modulates macrophage polarization. The invention is directed to the use of an antibody able to bind to csf-1r for modulating macrophage polarization.
Icam-1 antibody and use thereof
Disclosed are a monoclonal antibody targeting domain 2 of icam-1 protein and a composition comprising the monoclonal antibody for treating or preventing t cell-mediated immune disease. The antibody of the present application induces antigen-specific t cell tolerance through the regulation of dendritic cell differentiation, and therefore, can be effectively used to treat or prevent autoimmune disease, organ or tissue transplant rejection, and graft-versus-host-disease..
Snu R&db Foundation
Methods and compositions comprising human recombinant growth and differentiation factor-5 (rhgdf-5)
Expression vector systems are provided for increased production of a recombinant gdf-5 (rhgdf-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhgdf-5 protein.
Warsaw Orthopdedic, Inc.
Treatment of brain injury with a neurotrophic peptide
A neurotrophic peptide having the sequence vgdgglfekkl (seq id no: 1) may be used to help sustain local microenvironment after mild-to-moderate brain injury. Treatment with the peptide was shown to enhance differentiation of newly born progenitors in the dentate gyrus 30 days after injury and to promote neuronal maturation and survival that is not seen naturally after tramautic brain injuries..
The Research Foundation For Mental Hygiene, Inc.
Use of a compound for inducing differentiation of mesenchymal stem cells into cartilage cells
Use of a compound of formula 1 for inducing differentiation of mesenchymal stem cells to chondrocytes, and a pharmaceutical composition for treating a cartilage disease, which includes chondrocytes in which differentiation from mesenchymal stem cells is induced by the compound of formula 1, are provided. Differentiation of the mesenchymal stem cells treated with the compound of formula 1 to chondrocytes is specifically induced, and thus the compound can be used to effectively treat a cartilage disease such as arthritis, cartilage damage, and a cartilage defect..
Industry-academic Cooperation Foundation, Yonsei University
Method for producing retinal pigment epithelial cell sheet
The present invention provides a method of producing a cell sheet comprising a retinal pigment epithelial cell layer and a vascular forming cell layer composed of stem cells having vascular formation ability or blood vessel constituting cells, comprising a step of laminating the retinal pigment epithelial cell layer and the vascular forming cell layer, and a cell sheet obtained by said method. Furthermore, the present invention provides a cell sheet for transplantation, comprising a cell layer formed with retinal pigment epithelial cells obtained by inducing differentiation of stem cells or progenitor cells ex vivo, a basement membrane secreted from said cells, and a vascular forming cell layer composed of stem cells having vascular formation ability or blood vessel constituting cells..
Dopaminergic neurons differentiated from pluripotent stem cells and uses thereof
The present invention provides populations of neural cells derived from pluripotent cells, and methods for making and using the same. Disclosed herein are methods for generating dopaminergic neurons in vitro using a combination of agents that cause differentiation of the pluripotent cells into dopaminergic neurons.
The Mclean Hospital Corporation
Methods and compositions for expansion of stem cells and other cells
Presented herein are methods of generating a multipotent or immature cell from a mature somatic cell, involving contacting a mature somatic cell with one or more small molecule compounds selected from: a histone deacetylase (hdac) inhibitor; a glycogen synthase kinase 3 (gsk-3) inhibitor; one or more transforming growth factor-beta receptor (tgf-βr) inhibitors; one or more lysine-specific demethylase 1 (lsd1) inhibitors; a camp agonist; a histone lysine methyltransferase (ezh2) inhibitor; and a histone methyltransferase (hmtase) g9a inhibitor; valproic acid. Also provided are methods of generating a multipotent or immature cell from a somatic cell, by driving expression of oct4, or an oct4 functional homolog or derivative, under the control of a high expressing promoter.
The Research Foundation For The State University Of New York
Nitazoxanide and mebendazole synergic composition, processes for the preparation thereof, and use of said composition for the treatment of human parasitosis
The invention relates to a synergic pharmaceutical composition of mebendazole (mbdz) with nitazoxanide (ntzx) for the treatment of human parasitosis, which significantly increases the spectrum of mbdz against protozoa and reinforces the anthelmintic action of ntzx. Furthermore, when said pharmaceutical combination of mbdz and ntzx is used, the same effects of the individual active substances are maintained in the systemic action of the active metabolite of ntzx, tizoxanide, and in the treatment of some systemic forms of parasitosis.
Siegfried Rhein S.a. De C.v.
Potency assay for skeletal muscle derived cells
The present invention relates to a potency assay for skeletal muscle derived cells (smdc), the potency assay comprises the steps of (a) measuring ach e activity of smdc, and (b) evaluating the potential of the smdc to be used for the treatment of skeletal muscle dysfunction based on the ache activity measured in step (a). Moreover, the present invention relates to skeletal muscle derived cells (smdc) for use in the treatment of a muscle dysfunction.
Innovacell Bioyechnologie Ag
A method of treating a disease, disorder or condition of the eye includes irradiating the eye or eyes with a laser and subsequently detecting one or more biological responses by the eye or eyes to thereby determine the effectiveness of the laser treatment. The one or more biological responses by the eye or eyes are responses by cells, tissues and/or molecules of the eye or eyes that indicate, are associated with, or are functionally linked to, the effectiveness of the laser treatment.
Ellex Medical Pty Ltd.
Transcriptional profiling of stem cells and their multilineage differentiation
The present invention concerns methods of screening cells for differentiation or de-differentiation, and/or for status as a pluripotent or multipotent (e.g., “stem”) cell, by detecting the differential expression (e.g., upregulation, downregulation) of genes.. .
Wake Forest University Health Sciences
Method for growing mycological materials
The method of growing the basidiomycete mycelium includes inoculating a substrate that promotes the growth and differentiation of basidiomycete mycelium without supporting the production of a basidiocarp with a vegetative mycelium and thereafter incubating the inoculated substrate in a first incubation period at controlled temperature, humidity, light and carbon dioxide levels followed by a finishing incubation period.. .
Regeneration of spinal discs
Compositions and processes for the effective and efficient regeneration of spinal discs are provided. These compositions contain stem cells, donor cells, and platelet plasma compositions.
Laser Spine Institute, Llc
System and delivering data that provides service differentiation and monetization in mobile data networks
An exemplary system according to the present disclosure comprises a lower tier radiolet™ that is in communication with a local switching office of a mobile data network, and an upper tier radiolet™ that is in communication with the lower tier radiolet™ and an internet datacenter. In operation, the upper tier radiolet™ receives data extracted from the internet datacenter and distributes at least a portion of the received data to the lower tier radiolet™.
Alef Mobitech Inc.
Method and direct self assembly in target design and production
Target designs methods and targets are provided, in which at least some of the differentiation between target elements and their background is carried out by segmenting either of them. Directed self-assembly (dsa) processes are used to generate fine segmentation, and various characteristics of the polymer lines and their guiding lines are used to differentiate target elements from their background.
Media for culturing, preserving, and administering regenerative cells
A culture media, media supplement, or soluble matrix for cryopreservation or enhanced regenerative cell growth in culture and maintenance of multi-lineage differentiation potentiation. The inventive culture media, media supplement, or soluble matrix comprises a gag composition comprising a sulfated gag, such as chondroitin sulfate.
Arthrodynamic Technologies, Animal Health Division, Inc.
Brown adipocyte progenitors in human skeletal muscle
This invention relates to brown adipose tissue (bat) progenitor cells and methods for isolating bat progenitor cells from skeletal muscle. Bat progenitor cell surface markers and medium and agents for inducing cell differentiation into brown adipocytes are also provided.
Energesis Pharmaceuticals, Inc.
Conditionally immortalized long-term stem cells and methods of making and using such cells
Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (aml) and cells and methods related to such mouse model are also described..
The Regents Of The University Of Colorado
Monoclonal antibodies to growth and differentiation factor 15 (gdf-15)
The present invention relates to novel monoclonal anti-human-gdf-15 antibodies, pharmaceutical compositions, kits, methods and uses and the cell lines capable of producing the monoclonal antibodies described herein. The present invention further relates to novel antibodies to human gdf-15 capable of inhibiting cancer growth..
Syringes having tactile labeling elements
Syringes having various tactile and visual differentiation features are provided. Elements of differentiation ribs of various shapes and configurations are located on the syringe tube.
The present invention relates to peptide compounds that are capable of stimulating neuronal differentiation, neurite outgrowth and survival of neural cells, and enhancing synaptic plasticity, learning and memory, methods of treating diseases and conditions of nervous system by administration of compositions comprising said compounds. The compounds and compositions of the invention include peptide sequences that are derived from the sequence of human erythropoietin or proteins that are homologous of human erythropoietin..
Urine stem cells for skeletal muscle generation and uses thereof
Provided herein are methods of treating a subject in need of treatment for a urological condition including administering urine stem cells to said subject in a treatment effective amount; and, in conjunction therewith, administering growth factors to said subject in an amount effective to promote differentiation of said stem cells into skeletal muscle cells. Compositions useful for the same are also provided..
Wake Forest University Health Sciences
Power-on reset circuit
A power-on reset circuit of one embodiment includes first and second power supplies, first and second detecting circuit, a differentiation circuit, a current mirror circuit and a latch circuit. The second power supply is generated from a voltage of the first power supply and supplies a voltage lower than the first power supply.
Kabushiki Kaisha Toshiba
Mobile device application state
Techniques for mobile device application state are described. In one or more implementations, a mobile device includes a computing device that is flexibly coupled to an input device via a flexible hinge.
Microsoft Technology Licensing, Llc
Detection of subject biomarker diagnostic assay for dengue fever and the differentiation of dengue hemorrhagic fever
Vitronectin is found to be a biomarker of progression from dengue fever to dengue hemorrhagic fever according to the present invention. Assay of vitronectin in biological samples of dengue virus infected subjects aids in prognosis, diagnosis and treatment of the disease, particularly in prediction of progression from dengue fever to severe dengue i.e.
The Government Of The United States Of America As Represented By The Secretary Of The Department Of
Pharmaceutical composition containing core factor involved in proliferation and differentiation of central nervous cell
With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) crbn, 2) a nucleic acid encoding crbn, or 3) a stem cell or a neural progenitor cell in which crbn is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using crbn, are provided.. .
Igg stimulated remyelination of peripheral nerves
The present invention is based on the discovery of polyclonal igg's ability to promote schwann cell maturation, differentiation, and myelin production. Methods for treating non-idiopathic, demyelinating peripheral neuropathies in mammals, where the neuropathy is not immune-mediated or infection-mediated, through the administration of polyclonal igg are provided.
Baxter Healthcare Sa
Brown adipocyte differentiation-inducing agent
The present invention addresses the problem of providing a means which is effective for the induction of the differentiation of a brown adipocyte and therefore enables a brown adipocyte to be used for and applied to, for example, the prevention/treatment of obesity or metabolic syndrome. Provided is a brown adipocyte differentiation-inducing agent containing, as an active ingredient, (1) creg1 protein or (2) an expression vector carrying creg1 gene..
Chubu University Educational Foundation
Methods and systems for packet differentiation
Methods and systems are disclosed facilitate differentiated qos service for packets within a single packet stream. For example, extended qci values may be used to differentiate service of video packets associated with different priorities.
Vid Scale, Inc.
In vitro pancreatic differentiation of pluripotent mammalian cells
This invention relates to the in vitro differentiation of pluripotent cells into pancreatic progenitors by i) culturing pluripotent cells in a definitive endoderm (de) medium comprising a tgfp ligand, fibroblast growth factor (fgf), bone morphogenetic protein (bmp), a pi3k inhibitor and optionally a gsk3 β inhibitor to produce a population of definitive endoderm cells, ii) culturing the definitive endoderm cells in a first pancreatic medium comprising an activin antagonist; fgf; retinoic acid; and a bmp inhibitor to produce a population of dorsal foregut cells; iii) culturing the dorsal foregut cells in a second pancreatic medium comprising fgf, retinoic acid, a bmp inhibitor, and a hedgehog signalling inhibitor, and; iv) culturing the endoderm cells in a third pancreatic medium comprising fgf. The progenitor cells thus produced may be further differentiated into pancreatic endocrine cells.
Cambridge Enterprise Limited
Natural killer cells and uses thereof
Provided herein are methods of producing natural killer (nk) cells and nk progenitor cell populations using a two-step expansion and differentiation method. Also provided herein are methods of producing populations of nk cells and nk progenitor cell populations using a three-step expansion and differentiation method.
Compounds and methods for selectively targeting cancer stem cells
Described are compounds and methods useful for selectively targeting cancer stem cells. The compounds preferentially induce differentiation and/or reduce the proliferation of cancer stem cells relative to normal stem cells.
Methods for modulating bacterial infection
The present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria. More particularly, the present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria of the gastrointestinal (gi) tract.
Differentiation of probe reports based on quality
Methods for differentiating high quality probe reports in a plurality of probe reports include: (a) receiving, by a processor, a probe report from a probe source, wherein the probe report includes data indicative of a travel condition; (b) determining, by the processor, whether the probe report satisfies a criterion indicative of high quality data; and (c) identifying, by the processor, the probe report as being (i) suitable for use in modeling the travel condition if the probe report satisfies the criterion, or (ii) unsuitable for use in modeling the travel condition if the probe report does not satisfy the criterion. Systems for differentiating high quality probe reports in a plurality of probe reports are described..
Here Global B.v.
Prioritizing storage operation requests utilizing data attributes
Storage operation requests from any device of a computing environment can be numerous and frequent. In particular, if there is a high frequency initiation of storage operation requests to store, retrieve, or modify data, then targeted storage systems have to easily and quickly decide in which order to satisfy the storage operation requests, such as when two requests occur to retrieve identical data.
International Business Machines Corporation
Method and device for measuring various parameters of membrane electrode assembly in fuel cell
A method and a device for measuring various parameters of a membrane electrode assembly (mea) in a fuel cell. Hydrogen gas and nitrogen gas or air are supplied to the fuel cell to be tested.
Compendium of ready-built stem cell models for interrogation of biological response
The invention generally features methods for providing engineered pluripotent stem cells that can be used to study biological response and pathways, including differentiation and drug effects. For example, these cells are provided comprising two or more exogenous expression cassettes including a selectable or screenable marker under the control of different condition-responsive regulatory elements, such as differentiation-responsive promoters or regulatory element of a receptor, drug target, drug metabolizing enzyme or signaling pathway gene.
Cellular Dynamics International, Inc.
Cell evaluation method
The present invention relates to a cell evaluation method comprising evaluating a cell differentiation degree based on a cell thickness.. .
Dynamometer system control device
Provided is a dynamometer system control device capable of stable and highly responsive control. This dynamometer system control device is provided with a torque control device which outputs a torque command signal on the basis of an output signal (lc_det) of a load cell, and with a characteristic vibration suppression circuit which corrects the torque command signal to suppress the characteristic vibration of an oscillator and which inputs said signal to an inverter as a control input signal.
Promoter of differentiation from hepatic progenitor cell into hepatic cell, and use thereof
The present invention provides a promoter of differentiation from a hepatic progenitor cell into a hepatocyte, which contains a substance that suppresses expression of dnmt-1 or a substance that inhibits the function of dnmt-1 as an active ingredient, and a method of producing a hepatocyte (preferably hepatocyte with high maturity) from a hepatic progenitor cell.. .
Ds Pharma Biomedical Co., Ltd.
A method of manufacturing and/or using a scaffold assembly for stem cell culture and tissue engineering applications is disclosed. The scaffold at least partially mimics a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material.
U.s.a. As Represented By The Administrator Of The National Aeronautics And Space Administration
Autologous cell-based therapy for treating obesity
Compositions and methods for producing autologous brown adipose cells in vitro or in vivo are provided. In particular, a drug delivery device is described that recruits adipose stem cells (ascs) to a site in the body of a subject.
Non-contrast mri with differentiation of ischemic, infarct and normal tissue
Elicited mri signals are processed into mr image data in conjunction (a) with use of an initial spatially-selective rf tag pulse (tag-on) and (b) without use of an initial spatially-selective nmr rf tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (ti) intervals without using an injected contrast agent.
Toshiba Medical Systems Corporation
Downhole differentiation of light oil and oil-based filtrates by nmr with oleophilic nanoparticles
Downhole nuclear magnetic resonance (nmr) methods that utilize oleophilic nanoparticle may allow for differentiation of light oil and oil-based filtrates. For example, a method may involve drilling a wellbore penetrating a subterranean formation using an oil-based drilling fluid that comprises an oil base fluid and a plurality of oleophilic nanoparticles; performing a plurality of nmr measurements at a plurality of depths of investigation (doi) of a near-wellbore portion of the subterranean formation; and producing an invasion profile of an oil-based drilling fluid filtrate into the near-wellbore portion of the subterranean formation based on the plurality of nmr measurements..
Halliburton Energy Services, Inc.
Undifferentiated cell detection method and complex carbohydrate detection method
An object of the present invention is to provide a method for evaluating a differentiation status of cells using a culture supernatant of stem cells. Provided is “undifferentiation sugar chain marker” composed of the sugar chain structure “fucα1-2galβ1-3glcnac” or “fucα1-2galβ1-3galnac” and capable of sensitively determining the undifferentiated state of stem cells using a culture supernatant of stem cells.
Wako Pure Chemical Industries, Ltd.
Treatment of myelodysplastic syndrome by inhibition of nr2f6
Methods, compositions, and treatment protocols are provided in the current invention for the treatment of myelodysplastic syndrome (mds) through the inhibition of nr2f6 gene expression or activity of protein. In one embodiment silencing, or substantial inhibition of nr2f6 expression is achieved through induction of rna interference in cells associated with development of mds.
Method and device for preparing non-embryonic stem cells
The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, which has a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from such tissue derivative, wherein the tissue derivative or such cells are subjected to vibrations derived from a heart sound to control the degree of differentiation or possible differentiation of the stem and multipotent elements into several other types of cells and optimize their potency. The invention relates also to a device for carrying out the process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue..
Lipogems International Srl
This invention provides method and media suitable for inducing and supporting the differentiation of stem cells into erythroid cells.. .
University Court Of The University Of Glasgow
The disclosure relates to the fabrication of a three dimensional [3-d] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells.. .
Centre National De La Recherche Scientifique
Differentiation marker and differentiation control of eye cell
The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising gpr49/lgr5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to gpr49/lgr5.
Injectable brown adipose microtissues for treatment and prevention of obesity and diabetes
Provided are methods, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes by administration of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues to a subject, where the microtissues comprise adipose stem cells and endothelial cells. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3d cell aggregates..
The Trustees Of Columbia University In The City Of New York
Compounds for improved stem cell differentiation into hepatocytes
The invention relates to the compounds of formula i and pharmaceutically acceptable salts and esters thereof, wherein r1-r11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula i as well as pharmaceutical compositions containing such compounds.
Hoffmann-la Roche Inc.
Agent for treating urinary incontinence including stem cells derived from amniotic fluid
The present invention relates to a cell therapy product which is intended for regenerating a sphincter muscle and which contains stem cells derived from amniotic fluid, and more particularly, to a cell therapy product which is intended for regenerating the sphincter vesicae and which contains stem cells derived from amniotic fluid. Also, the cell therapy product of the present invention can be provided in the form of a formulation for administration through injection, said formulation being injected into a hydrogel complex to thereby improve the effects thereof.
Kyungpook National University Hospital
Method and determining degree of stratification and/or differentiation
A method for easily and non-invasively determining a degree of stratification and/or differentiation of cultured cells, and an apparatus for determining a degree of stratification and/or differentiation of cultured cells are provided. The invention relates to a method for determining a degree of stratification and/or differentiation of cultured cells, including: (a) a harvesting step of harvesting a culture solution of the cultured cells; (b) an analytical step of analyzing at least one type of a metabolite of the pentose phosphate pathway and/or the tca cycle in the culture solution; and (c) a determination step of referring to a database of correlations between prospectively-obtained degrees of stratification and/or differentiation of the cultured cells and analytical results of metabolites, for analytical results obtained in the analytical step, to determine the degree of stratification and/or differentiation of the cultured cells..
Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling
The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal crispr/cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state..
University Of Massachusetts
Differentiation of human embryonic stem cells
The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage..
Janssen Biotech, Inc.
Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
The disclosure provided herein relates generally to mesenchymal-like stem cells “hes-t-misc” or “t-msc” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblasts to hes-t-msc or t-msc, t-msc derived cells and cell lineages “t-msc-dl” are also described.
Imstem Biotechnology, Inc.
Adipose-derived stem cells and lattices
The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells.
University Of Pittsburgh Of The Commonwealth System Of Higher Education
Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of rock inhibitors are described.
Cellular Dynamics International, Inc.
Composition including gelsolin as effective ingredient for inducing differentiation into dendritic cell and inducing differentiation into dendritic cell
Disclosed are a composition including gelsolin as an effective ingredient for inducing differentiation into a dendritic cell, a method of inducing differentiation by using the composition, and a vaccine composition for treating cancer or an immune-mediated disease. In addition, a composition including gelsolin as an effective ingredient for inducing differentiation into a dendritic cell and a method of inducing differentiation into a dendritic cell by treating an immature dendritic cell with gelsolin are also disclosed.
Korea Institute Of Radiological & Medical Services
Bone matrix compositions and methods
An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier.
Warsaw Orthopedic, Inc.
Methods of using ceo2 and tio2 nanoparticles in modulation of the immune system
Redox-active nps are disclosed that can potentiate innate immunity and stimulate distinct adaptive responses, producing distinct t cell subset polarization outcomes. Nanomaterials that can alter the cellular redox environment through ros modulation can impact human immunology.
Sanofi Pasteur Vaxdesign Corp.
Use of kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function
The present invention relates to a pharmaceutical composition containing kaempferia parviflora wall. Ex.
Industry-academic Cooperation Foundation, Yonsei University