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Differentiation patents



      
           
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Date/App# patent app List of recent Differentiation-related patents
04/17/14
20140108803
 Steganographic messaging system using code invariants patent thumbnailnew patent Steganographic messaging system using code invariants
A steganographic method to prevent the execution of malicious code and mitigate software piracy. The method uses invariant portions of machine instructions to create an executable watermark within unmodified code.
04/17/14
20140108067
 Using qualification events to provide price differentiation for travel products patent thumbnailnew patent Using qualification events to provide price differentiation for travel products
The disclosed embodiments provide a system that facilitates a purchase of a travel product. Upon detecting a participation of a user in a first qualification event associated with a first market segment, the system associates the user with the first market segment.
04/17/14
20140105870
 Differentiation of human ips cells to human alveolar type ii via definitive endoderm patent thumbnailnew patent Differentiation of human ips cells to human alveolar type ii via definitive endoderm
The present invention relates to compositions and methods for generating populations of tissue precursor cells from pluripotent cells, and preferably induction of stem cells into definitive endoderm to generate anterior foregut endoderm from pluripotent cells. The anterior foregut endoderm cells can then be differentiated into an alveolar epithelial type ii cell..
04/10/14
20140099709
 Engineered three-dimensional connective tissue constructs and methods of making the same patent thumbnailEngineered three-dimensional connective tissue constructs and methods of making the same
Disclosed are engineered, living, three-dimensional connective tissue constructs comprising connective tissue cells. In some embodiments, the connective tissue cells are derived from multi-potent cells such as mesenchymal stem/stromal cells.
04/10/14
20140099639
 Panel for the detection and differentiation of renal cortical neoplasms patent thumbnailPanel for the detection and differentiation of renal cortical neoplasms
The present invention provides a novel, highly sensitive and specific probe panel which detects the type of renal cortical neoplasm present in a biopsy sample. As such, the invention permits diagnosis of the predominant subtypes of renal cortical neoplasms without the use of invasive methods.
04/03/14
20140095284
 Using upgrade options to provide price differentiation for travel products patent thumbnailUsing upgrade options to provide price differentiation for travel products
The disclosed embodiments provide a system that facilitates a purchase of a travel product. Upon receiving a commitment to purchase the travel product from a first supplier by a buyer, the system presents the buyer with a first upgrade option of a first premium travel product from a second supplier.
04/03/14
20140095220
 Using upgrade options to provide price differentiation for travel products patent thumbnailUsing upgrade options to provide price differentiation for travel products
The disclosed embodiments provide a system that facilitates a purchase of a travel product. Upon receiving a commitment to purchase the travel product from a first supplier by a buyer, the system presents the buyer with a first upgrade option of a first premium travel product from a second supplier.
04/03/14
20140094425
 Methods for transdifferentiation of body tissues patent thumbnailMethods for transdifferentiation of body tissues
The invention relates to methods for transdifferentiation of body tissues which can be used to generate specific cell types needed for regenerating organs or body parts, following cellular degeneration, injury or amputation. The present invention also describes the use of tissue transdifferentiation for treating cancer and autoimmune diseases..
04/03/14
20140093960
 Cell differentiation inducer and differentiation inducing method patent thumbnailCell differentiation inducer and differentiation inducing method
The objective of the present invention is to provide a cell differentiation inducer which is a low-molecular compound, which can be chemically synthesized easily and which can efficiently induce a differentiation of an undifferentiated cell into a nervous system cell with high selectivity. In addition, the objective of the present invention is to provide use of a specific catechol derivative for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity, and a method for efficiently inducing a differentiation of an undifferentiated cell into a nervous system cell with high selectivity using a specific catechol derivative.
04/03/14
20140093539
 Protein a compositions and methods of use patent thumbnailProtein a compositions and methods of use
Methods and compositions for modulating an immune response in a subject are provided. Methods include administering to the subject a composition comprising an effective amount of a lymphocyte differentiation factor, e.g., protein a (pa), sufficient to modulate the immune response.
03/27/14
20140088158
Acylamino-substituted cyclic carboxylic acid derivatives and their use as pharmaceuticals
Wherein a, y, z, r20 to r22 and r50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (edg-2, edg2), which is activated by lysophosphatidic acid (lpa) and is also termed as lpa1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example.
03/27/14
20140088001
Methods for diagnosing organ specificity of glucose intolerance
The present application pertains to a technique useful for the differentiation and diagnosis of organ specificity of hyperglycemia and glucose intolerance in type 2 diabetes, pre-diabetes or populations with risk to develop type 2 diabetes.. .
03/27/14
20140087966
Detection and differentiation of demodex mites
Methods of detecting d. Gatoi or d.
03/27/14
20140087481
Scd fingerprints
The present invention relates to the use of cluster of differentiation (cd) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed cd (scd) molecules in detecting and assessing the progression of one or more disease states in an individual.
03/27/14
20140086920
Antagonist antibodies against gdf-8 and uses in treatment of als and other gdf-8 associated disorders
The disclosure provides novel molecules related to growth and differentiation factor-8 (gdf-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit gdf-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (als).
03/27/14
20140086863
Cosmetic composition
Provided is a method of treating aged skin, comprising topically applying to the aged skin a composition comprising a compound of formula (i) in an amount effective to provide an anti-ageing effect. The compound of formula (i) is used to prevent skin and/or to help to maintain or improve moisture retention and/or to fight against the signs of skin ageing.
03/20/14
20140080902
B- and y -diketones and y -hydroxyketones as wnt/ b -catenin signaling pathway activators
The present invention discloses β-diketones, γ-diketones or γ-hydroxyketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .
03/13/14
20140073648
Methods for treating immunologic disease using aminothiazole-based inhibitor of myd88
A method of treating an immunologic disease. The method includes administering an aminothiazole-based inhibitor of myeloid differentiation protein 88 (myd88) to a patient in need thereof.
03/13/14
20140073569
Method for generating immunomodulatory cells, the cells prepared therefrom and use thereof
The present invention develops a straightforward and rapid method for generating immunomodulatory cells from peripheral mononuclear cells, comprising treating peripheral mononuclear cells with a hepatocyte growth factor (hgf) to induce differentiation of the peripheral mononuclear cells into immunomodulatory leukocytes. The present invention also provides an immunomodulatory cell prepared according to this method.
03/13/14
20140073525
Diagnostic, prognostic and therapeutic uses of long non-coding rnas for cancer and regenerative medicine
Long non-coding rnas (lncrnas) and methods of using them diagnostically and therapeutically for treatment of cancer, stem cell therapy, or regenerative medicine are disclosed. In particular, the invention relates to lncrnas that that play roles in regulation of genes involved in cell proliferation, differentiation, and apoptosis.
03/13/14
20140073002
Method for determining differentiation level of pluripotent stem cells
The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication.. .
03/13/14
20140072637
Treatment for bone formation disorders by growth factor delivery
It has been discovered that that certain growth factors can delay the ossification of a tissue site, such as a cranial suture, via the promotion of fibroblast differentiation and/or inhibition of osteoblast differentiation. Provided herein are methods for treating bone formation conditions or disorders, such as synostotic conditions, or ectopic mineralization conditions, via administration of compositions comprising connective tissue growth factor (ctgf), and optionally other growth factors or fibroblast or progenitor cells, to a tissue site of a subject in need thereof..
03/13/14
20140072230
Image processing device and image processing method
An image processing device for identifying a characteristic of an eye from a face image comprising: a first differentiation unit configured to differentiate an eye region in a crosswise direction of the eye to obtain a first luminance gradient; a first edge extraction unit configured to extract a first and a second edge points; a voting unit configured to vote for an ellipse; a pupil outline identification unit configured to identify an ellipse expressing a pupil outline; a second differentiation unit configured to obtain a second luminance gradient by differentiating in a vertical direction; a second edge extraction unit configured to extract a third edge point; a curve identification unit configured to identify a curve that fits to the third edge point as a curve expressing an eyelid outline; and a pupil region identification unit configured to identify a pupil region based on the identified ellipse and the identified curve.. .
03/06/14
20140068794
R2r1/2 in diagnosis and therapy
The present invention stems from the finding that two genes designated r2r1 and r2r2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered that these two genes are expressed in pulmonary cells and are required for late branching morphogenesis of pulmonary epithelium and endothelium and support the development/maintenance of the refined three dimensional architecture of the lung.
03/06/14
20140068257
Method for handling privacy data
The present invention aims to improve data protection against illegal access by a strong differentiation of the security level specific on a type of data so that when the protection on a part of the data is violated, the remaining data are still inaccessible. A method for controlling access, via an open communication network, to user private data, comprising steps of: dividing the user private data into a plurality of categories, each category defining a privacy level of the data, encrypting the user private data of each category with a category key pertaining to the category of the data, attributing to a stakeholder an entity configured for accessing to at least one category of user private data, and authorizing the access to the at least one category of user private data for the entity of the stakeholder, by providing the stakeholder with the category keys required for decrypting the user private data of the corresponding category..
03/06/14
20140067780
Simultaneous maintenance of multiple versions of a web-based business information system
A method, system, computer program product, and related business methods for phased rollout of an upgraded version of a web-based business information system are described. Urls associated with client requests remain the same even where the target subscriber accounts have been upgraded.
03/06/14
20140067289
Integrated vibration measurement and analysis system
A vibration data collection system performs an integration or differentiation process on incoming digitized vibration data in real time. The system uses a digital infinite impulse response (iir) filter running at the input data rate to provide the integration or differentiation function.
03/06/14
20140066439
Osteoclast activity
Described are medicaments and methods of treating or preventing metabolic bone diseases, such as critical illness related metabolic bone disease or of critical illness induced osteopenia secondary to icu admission by sufficient autophagy inducing compound to inhibit or suppress critical illness enhanced osteoclastogenesis or increased osteoclast differentiation. The methods include administering of an autophagy activating compound to a mammal to: treat or prevent a bone degenerative disorder; slow bone deterioration; restore lost bone; maintain bone mass and/or bone quality or inhibit bone resorption in particularly by inhibiting or reducing a process by which osteoclasts break down bone and release the minerals resulting in a transfer of calcium from bone fluid to the blood.
03/06/14
20140065628
Methods and devices for multi-color, out-of-phase detection in electrophoresis
The disclosure provides methods and devices for separating and detecting nucleic acid fragments labeled with a plurality of spectrally resolvable dyes using a single light source or multiple light sources. Use of a greater number of light sources increases the number of spectrally resolvable dyes that can be interrogated.
03/06/14
20140065480
Positive-electrode active material, manufacturing method of the same, and nonaqueous electrolyte rechargeable battery having the same
A positive-electrode active material for a non-aqueous electrolyte rechargeable battery includes a core portion and a shell portion. The core portion includes at least one of an inorganic oxide having a polyanionic structure and an inorganic compound oxide having a polyanionic structure and including a carbon.
03/06/14
20140065246
Intracellular calcium modulation for cancer treatment
Tumor cells exhibit consistent abnormalities in calcium regulation. The present disclosure teaches methods by which such differences are exploited to induce apoptosis selectively in tumor/cancer cells while sparing normal cells.
03/06/14
20140065112
Compositions and methods for mesenchymal/stromal stem cell rejuvenation and tissue repair by enhanced co-expression of telomerase and myocardin
A major risk factor for ischemic heart disease is advanced age. In adult bone marrow and other tissues, the number and function of stem cells decline with aging.
03/06/14
20140064245
Systems and methods for dynamic association ordering based on service differentiation in wireless local area networks
Embodiments relate to systems and methods for dynamic association ordering based on service differentiation in wireless local area networks. A wifi™ or other access point can broadcast beacon information to surrounding stations, and receive probe requests from those stations seeking to associate with the access point.
02/27/14
20140057350
Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
The present invention relates to a pharmaceutical composition comprising of preparations of human embryonic stem (hes) cells and their derivatives and methods for their transplantation into the human body, wherein transplantation results in the clinical reversal of symptoms, cure, stabilization or arrest of degeneration of a wide variety of presently incurable and terminal medical conditions, diseases and disorders. The invention further relates to novel processes of preparing novel stem cell lines which are free of animal products, feeder cells, growth factors, leukaemia inhibitory factor, supplementary mineral combinations, amino acid supplements, vitamin supplements, fibroblast growth factor, membrane associated steel factor, soluble steel factor and conditioned media.
02/27/14
20140057250
Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
The present invention relates to a pharmaceutical composition comprising of preparations of human embryonic stem (hes) cells and their derivatives and methods for their transplantation into the human body, wherein transplantation results in the clinical reversal of symptoms, cure, stabilization or arrest of degeneration of a wide variety of presently incurable and terminal medical conditions, diseases and disorders. The invention further relates to novel processes of preparing novel stem cell lines which are free of animal products, feeder cells, growth factors, leukaemia inhibitory factor, supplementary mineral combinations, amino acid supplements, vitamin supplements, fibroblast growth factor, membrane associated steel factor, soluble steel factor and conditioned media.
02/27/14
20140056945
Pharmaceutical composition for treating or preventing cancer by inducing dendritic cell-like differentiation from monocytes to improve anticancer immune activity
(b) a protein consisting of an amino acid sequence derived from the amino acid sequence shown in seq id no: 2 by substitution, deletion, or addition of one or more amino acid(s) and having the activity of inducing differentiation from monocytes into dendritic cell-like cells.. .
02/27/14
20140056529
Image processing device and image processing method
An image processing device for identifying a characteristic of an eye from a face image comprising: a first differentiation unit configured to differentiate an eye region in at least a vertical direction of the eye to obtain a first luminance gradient; a first edge extraction unit configured to extract a first edge point according to the first luminance gradient; and a curve identification unit configured to identify a curve, which is a b-spline curve or a bezier curve expressed by a control point and both end points and fits to the first edge point, as a curve expressing an upper-eyelid or lower-eyelid outline, the end points being an inner corner point of eye and a tail point of eye, by voting for the control point that is a voting target with respect to the first edge point using the hough transform.. .
02/27/14
20140055108
Power supply device, control circuit, electronic device and control method for power supply
A power supply device that includes a switch circuit to which an input voltage is supplied, a coil coupled between the switch circuit and an output terminal from which an output voltage is outputted. A voltage adding circuit adds a slope voltage to a reference voltage.
02/20/14
20140051583
Noninvasive diagnosis of fetal aneuploidy by sequencing
Disclosed is a method to achieve digital quantification of dna (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated.
02/20/14
20140051164
Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
The present invention relates to a pharmaceutical composition comprising of preparations of human embryonic stem (hes) cells and their derivatives and methods for their transplantation into the human body, wherein transplantation results in the clinical reversal of symptoms, cure, stabilization or arrest of degeneration of a wide variety of presently incurable and terminal medical conditions, diseases and disorders. The invention further relates to novel processes of preparing novel stem cell lines which are free of animal products, feeder cells, growth factors, leukaemia inhibitory factor, supplementary mineral combinations, amino acid supplements, vitamin supplements, fibroblast growth factor, membrane associated steel factor, soluble steel factor and conditioned media.
02/20/14
20140051110
Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
The present invention relates to a pharmaceutical composition comprising of preparations of human embryonic stem (hes) cells and their derivatives and methods for their transplantation into the human body, wherein transplantation results in the clinical reversal of symptoms, cure, stabilization or arrest of degeneration of a wide variety of presently incurable and terminal medical conditions, diseases and disorders. The invention further relates to novel processes of preparing novel stem cell lines which are free of animal products, feeder cells, growth factors, leukaemia inhibitory factor, supplementary mineral combinations, amino acid supplements, vitamin supplements, fibroblast growth factor, membrane associated steel factor, soluble steel factor and conditioned media.
02/20/14
20140050706
Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
The present invention relates to a pharmaceutical composition comprising of preparations of human embryonic stem (hes) cells and their derivatives and methods for their transplantation into the human body, wherein transplantation results in the clinical reversal of symptoms, cure, stabilization or arrest of degeneration of a wide variety of presently incurable and terminal medical conditions, diseases and disorders. The invention further relates to novel processes of preparing novel stem cell lines which are free of animal products, feeder cells, growth factors, leukaemia inhibitory factor, supplementary mineral combinations, amino acid supplements, vitamin supplements, fibroblast growth factor, membrane associated steel factor, soluble steel factor and conditioned media.
02/20/14
20140050705
Agent for treating urinary incontinence including stem cells derived from amniotic fluid
The present invention relates to a cell therapy product which is intended for regenerating a sphincter muscle and which contains stem cells derived from amniotic fluid, and more particularly, to a cell therapy product which is intended for regenerating the sphincter vesicae and which contains stem cells derived from amniotic fluid. Also, the cell therapy product of the present invention can be provided in the form of a formulation for administration through injection, said formulation being injected into a hydrogel complex to thereby improve the effects thereof.
02/20/14
20140050379
Non-contrast mri with differentiation of ischemic, infarct and normal tissue
Elicited mri signals are processed into mr image data in conjunction (a) with use of an initial spatially-selective rf tag pulse (tag-on) and (b) without use of an initial spatially-selective nmr rf tag pulse (tag-off) in respectively corresponding data acquisition subsequences. Multi-dimensional tag-on and tag-off data acquisition subsequences are used for each of plural time-to-inversion (ti) intervals without using an injected contrast agent.
02/13/14
20140047396
P and n region differentiation for image-to-cad alignment
In one embodiment, a method for aligning an image of a semiconductor device with a bitmap representation thereof includes receiving diffusion layer information of at least a portion of the semiconductor device, receiving implant layer information of the at least a portion of the semiconductor device, deriving distinct p- and n-doped region information from the received diffusion and implant layer information, generating the bitmap representation, including a differentiation between the distinct p- and n-doped regions, and performing an alignment operation of the image of the semiconductor device with generated bitmap representation.. .
02/13/14
20140045506
Method and apparatus for providing differentiated services in communications network
A method and a mobile services switching centre of providing differentiated services in a communications network. The method comprises receiving in a mobile services switching centre an indication message from a first radio access network, said message indicating a radio access network type to which a called communication apparatus of a terminating communication session is connected, in response to the indication message: accessing differentiated service information associated with the radio access network type of the terminating communication session, and sending the differentiated service information to be applied for service differentiation by a second access network of calling communication apparatus..
02/13/14
20140045265
Robust and efficient differentiation of human pluripotent stem cells to multipotent vascular progenitors
Provided herein are methods and compositions for generating vascular progenitor cells that can in turn be differentiated into endothelial, smooth muscle, and hematopoietic cells. The present methods provide a faster, safer, and more efficient in vitro differentiation program than existing methodologies.
02/13/14
20140044754
Tdf-related compounds and analogs thereof
The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
02/06/14
20140040265
Method and apparatus for representing multidimensional data
The present invention relates to methods for representing multidimensional data. The methods of the present invention are well suited but not limited to the representation of multidimensional data in such a way as to enable the comparison and differentiation of data sets.
02/06/14
20140038949
Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent.
02/06/14
20140038908
Polynucleotides and polypeptides associated with trophoblast cell death, differentiation, invasion and/or cell fusion and turnover
The invention relates to polypeptides and polynucleotides associated with trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover, and uses of same in the prevention, diagnosis and treatment of conditions requiring regulation of trophoblast cell death, differentiation, invasion, and/or cell fusion and turnover. In particular aspects, diagnostic methods are disclosed for evaluating conditions such as preeclampsia utilizing matador polypeptides and polynucleotides encoding same..
02/06/14
20140038847
Screening and culturing device and methods for the use thereof
In accordance with one aspect of the present invention, screening and culturing devices have been developed which are useful for the identification of media which support cell viability, growth and/or proliferation, and transformation and/or differentiation. In a further aspect, screening and culturing methods employing the invention screening and culturing devices have been developed.
02/06/14
20140038293
Methods for the production of ips cells using non-viral approach
Methods and composition of induction of pluripotent stem cells and other desired cell types are disclosed. For example, in certain aspects methods for generating essentially vector-free induced pluripotent stem cells are described.
02/06/14
20140038291
Methods for reprogramming cells and uses thereof
Described herein are reprogrammed cells, and methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also descried are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming.
02/06/14
20140038258
Bioreactor with mechanical and electrical stimulation means
Disclosed herein is a bioreactor for creating and/or conditioning biological tissues, in particular cardiovascular patches. This bioreactor supports additionally cellular differentiation under controlled conditions.
02/06/14
20140037607
Culture medium and method for obtaining a population of tolerogenic dendritic cells
The present invention relates to a culture medium suitable for inducing dendritic cell differentiation comprising an effective amount of secretory immunoglobulins a (siga) and also to a method for obtaining a population of tolerogenic dendritic cells from cells, in particular monocytes. The present invention relates to uses of tolerogenic dendritic cells thus obtained in therapy and in induction of transplant tolerance..
02/06/14
20140037596
Use of stem cells to reduce leukocyte extravasation
The invention is generally directed to reducing inflammation by means of cells that secrete factors that reduce leukocyte extravasation. Specifically, the invention is directed to methods using cells that secrete factors that downregulate the expression of cellular adhesion molecules in vascular endothelial cells.
02/06/14
20140037546
Mixture of liquid-crystal compounds, system of three liquid-crystal mixtures and their use
Three organic compounds mixtures of liquid-crystal properties, which when mixed together in a precisely determined weight ratio, may show an ability to form thermo-optically active mesophases of established, narrow range thermooptical transitions separation, every 0.5° c., in the temperature range: from 31.8° c. To 32.8° c., from 32.8° c.
01/30/14
20140033068
Collaborative review apparatus, systems, and methods
Apparatus, systems, and methods may operate to within the context of a shared document review process to receive an updated comment associated with an original comment by a comment series identifier. Further actions may include generating a comment differentiation identifier that serves to differentiate the updated comment from the original comment, and storing at least a portion of the updated comment and the comment differentiation identifier in a collaboration comment repository.
01/30/14
20140032189
Method for model-based determination of a temperature distribution of an exhaust gas post-treatment unit
In a method for a model-based determination of a temperature distribution of an exhaust gas post-treatment unit, a differentiation is made between steady operating states and non-steady operating states by taking into account the axial and the radial temperature distribution, and, on the basis of virtual segmentation of the post-treatment unit, in particular the radial heat transfer to the surroundings is taken into account in the model-based determination for steady operating states, and for non-steady operating states the heat transfer from the exhaust gas which flows axially through the post-treatment unit to the segments is taken into account by a heat transfer coefficient k.. .
01/30/14
20140031563
New compounds for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof
New compounds and pharmaceutical compositions comprising active ingredients having inhibition effects on osteoclast differentiation are provided. The pharmaceutical compositions comprising the new compounds can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and paget's disease..
01/30/14
20140031400
Macrocyclic compounds and methods of treatment
The instant invention describes macrocyclic compounds having therapeutic activity, and methods of treating disorders such as cancer, tumors and cell proliferation related disorders, or affect cell differentiation, dedifferentiation or transdifferentiation.. .
01/30/14
20140030804
Animal cell culture kit, method for culturing animal cells, method for selective culture of animal cells and cell differentiation method
The invention provides an animal cell culture kit to be used favorably for culturing animal cells, a method for culturing animal cells, a method for culturing selectively animal cells, and a method for differentiating a cell. An animal cell culture kit according to the invention includes an incubator containing one or more types of functional groups selected from the group consisting of hydrophilic functional groups and hydrophobic functional groups at predetermined contents on a surface, and a serum-free culture medium.
01/30/14
20140030317
Modulation of cell fates and activities by phthalazinediones
Phthalazinediones that function as intracellular redox modulators are useful in treating cells in various disease states where intracellular redox status is impaired. By buffering aberrant redox states, phthalazinediones enable cellular processes essential for survival and augment medical treatments.
01/30/14
20140030295
Use of sirt1 activators or inhibitors to modulate an immune response
The present disclosure provides a method of increasing an immune response in an individual, the method involving administering to an individual in need thereof an inhibitor of sirt1. The present disclosure provides a method of reducing an immune response, e.g., to treat chronic immune hyperactivity, the method generally involving administering to an individual in need thereof an activator of sirt1.
01/30/14
20140030236
Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells
Embryonic vascular smooth muscle cells (vsmcs) have a synthetic phenotype (syn-vsmc), but in adults, they commit to the mature contractile phenotype (con-vsmc). Con-vsmcs differ from syn-vsmc derivatives in condensed morphology, prominent filamentous cytoskeleton proteins, elastin production and assembly elastin, low proliferation, numerous active caveolae, enlarged endoplasmic reticulum, ample stress fibers and bundles, as well as high contractility.


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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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