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Differentiation patents



      
           
This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS


Date/App# patent app List of recent Differentiation-related patents
12/11/14
20140366224
 Process for modifying the architecture and improving the yield of crop plants patent thumbnailProcess for modifying the architecture and improving the yield of crop plants
This invention identifies the plant miniyo (iyo) gene and the atrtr1 gene for the initiation of cell differentiation in all plant meristems and in embryogenesis. This invention relates methods for generating transgenic plants in which expression of the iyo and/or atrtr1 genes or their orthologous genes is modified to advancing or delaying the onset of differentiation in one or more meristems of the plant..
12/11/14
20140364467
 Chemical inducers of neurogenesis patent thumbnailChemical inducers of neurogenesis
The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo.
12/11/14
20140364402
 Assay for screening compounds that selectively decrease the number of cancer stem cells patent thumbnailAssay for screening compounds that selectively decrease the number of cancer stem cells
The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (cscs). This method includes (a) contacting a csc from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the csc or increases differentiation of the csc relative to a csc that has not been contacted with the candidate agent.
12/11/14
20140363888
 Method for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells patent thumbnailMethod for inducing differentiation of human pluripotent stem cells into intermediate mesoderm cells
The present invention provides a method for inducing differentiation of a human pluripotent stem cell into an intermediate mesoderm cell without the use of a growth factor. Such method comprises performing culture in a medium containing a specific compound, so as to induce differentiation of a human pluripotent stem cell into an intermediate mesoderm cell..
12/11/14
20140363883
 Device for cell culture and direct imaging patent thumbnailDevice for cell culture and direct imaging
A cell culture device for the study of barrier function and differentiation are provided by this invention.. .
12/11/14
20140363834
 Methods and compositions for diagnosis and prognosis of renal injury and renal failure patent thumbnailMethods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of growth/differentiation factor 2, catalase, vascular endothelial growth factor c, and melanoma-derived growth regulatory protein as diagnostic and prognostic biomarkers in renal injuries..
12/11/14
20140363409
 Lactobacillus reuteri dsm 17938 for the development of the enteric nervous system patent thumbnailLactobacillus reuteri dsm 17938 for the development of the enteric nervous system
The invention relates to lactobacillus reuteri dsm 17938, and compositions comprising lactobacillus reuteri dsm 17938, for promoting the healthy development and/or repair of the enteric nervous system in mammals. Humans or animals and, in particular, a foetus, pre-term or term-born infant, toddler or child may benefit from the invention.
12/11/14
20140362912
 Picture coding and decoding patent thumbnailPicture coding and decoding
A picture with multiple slices is encoded by generating a coded slice representation for each of the slices. A slice flag is set to a first value for the first slice in the picture and corresponding slice flags of the remaining slices are set to a second defined value.
12/04/14
20140359897
 Method for modulating the number of archesporial cells in a developing anther patent thumbnailMethod for modulating the number of archesporial cells in a developing anther
Certain embodiments provide a method of altering the number of archesporial cells in a developing anther of a plant in certain embodiments, the method comprises exposing the anther to redox-modulatory conditions prior to differentiation of germline cells in the anther, thereby changing the redox potential of cells in the anther and altering the number of archesporial cells in the anther. This method may be employed to increase or decrease the number of archesporial cells in a developing anther, and may be employed to produce male sterile plants..
12/04/14
20140359039
 Differentiation of messages for receivers thereof patent thumbnailDifferentiation of messages for receivers thereof
A solution for sending messages on a data-processing system is proposed. A corresponding method comprises upon a message to be sent from a sender to at least one receiver being submitted, parsing the message to identify an original expression therein matching an indication of one of a set of pre-defined concepts, determining, for the receiver, a preferred expression of the matched concept, among the corresponding original expression and a set of candidate expressions pre-defined to express the matched concept, according to a rating thereof representing an expected understanding by the receiver, processing the message for the receiver by replacing the original expression according, to the corresponding preferred expression for the receiver, and sending the processed message to the corresponding receiver..
12/04/14
20140359030
Differentiation of messages for receivers thereof
A solution for sending messages on a data-processing system is proposed. A corresponding method comprises upon a message to be sent from a sender to at least one receiver being submitted, parsing the message to identify an original expression therein matching an indication of one of a set of pre-defined concepts, determining, for the receiver, a preferred expression of the matched concept, among the corresponding original expression and a set of candidate expressions pre-defined to express the matched concept, according to a rating thereof representing an expected understanding by the receiver, processing the message for the receiver by replacing the original expression according, to the corresponding preferred expression for the receiver, and sending the processed message to the corresponding receiver..
12/04/14
20140358447
Instant, in-situ, nondestructive material differentiation apparatus and method
Specular, ultrasonic, piezoelectric, detection devices provide real-time, analytical, edge finding in tissues during tumor surgery. Piezoelectric probe sensors at high frequencies (e.g., 10 to 100 mhz) characterize microstructure of cells and tissues.
12/04/14
20140357555
Novel monascuspurpurones, preparation process thereof, and uses of the monascuspurpurones
Or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses to of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of pparγ and/or c/ebpα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided..
12/04/14
20140357509
Differentiation between transient and persistent high-risk hpv infection by in situ hybridization
The invention relates to methods of categorizing a cervical tissue or cytology sample by performing an in situ hybridization assay using an antisense e6 or e7 probe on a cervical tissue sample, wherein the antisense e6 or e7 probe can simultaneously detect hpv dna and hpv rna; detecting the presence of hpv nucleic acid; and categorizing the cervical tissue sample based on hpv nucleic acid expression.. .
12/04/14
20140356893
Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation
Methods are described for using compositions containing platelet-rich plasma for the treatment of a variety of tissue lesions, and the use of compositions containing platelet-rich plasma to accelerate or complete the differentiation of a cell line. Particularly, use of platelet-rich plasma in conjunction with cell differentiation..
12/04/14
20140356369
Antibodies to human gdf8
The present invention provides isolated human or humanized antibodies or antigen-binding fragments thereof which specifically bind to growth and differentiation factor-8 (gdf8) and block gdf8 activity. The antibodies and antibody fragments of the present invention may be used in therapeutic methods for treating conditions or disorders which are ameliorated or improved by inhibition of gdf8..
12/04/14
20140356336
Method for inducing differentiation enabling tumorigenesis of ips cells to be suppressed
The object of the invention is to provide a technique of suppressing tumorigenesis in ips cells and inducing differentiation into target differentiated cells. In use of a statin and a differentiation inducer, ips cells are differentiated into target differentiated cells, whereby ips cells can be differentiated into differentiated cells in which tumorigenesis is suppressed..
12/04/14
20140356333
Nail stem cells and methods of use thereof
The present invention is directed to an in vitro method for promoting proliferation, survival, and/or differentiation of k14+, k17+ nail stem cells (nscs). The instant methods may be used to generate an expanded population of k14+, k17+ nscs in vitro and expanded nsc populations in which a wnt pathway is activated are envisioned as therapeutic agents.
11/27/14
20140350649
Methods for modulating osteochondral development using bioelectrical stimulation
Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications.
11/27/14
20140350547
Catheter with omni-directional optical lesion evaluation
A catheter is adapted to ablate tissue and provide lesion qualitative information on a real time basis, having an ablation tip section with a generally omni-directional light diffusion chamber with one openings to allow light energy in the chamber to radiate the tissue and return to the chamber. The chamber is irrigated at a positive pressure differential to continuously flush the opening with fluid.
11/27/14
20140349919
Chromane-like cyclic prenylflavonoids for the medical intervention in neurological disorders
The present invention relates to certain chromane-like cyclic prenylflavonoids, in particular the compounds of formulae (i), (ii) and (iii) as described and defined herein, for use in the treatment or prevention of a neurological disorder, as well as their use in promoting neuronal differentiation, neurite outgrowth and neuroprotection.. .
11/27/14
20140349866
New th-17 differentiation markers for rosacea and uses thereof
Methods are described for using genes crucial in th17 differentiation, il-12rbeta 1/il-23r, ccr6, batf, ahr, stat3 and irf4 as new markers for rosacea. Also described, are methods of their use to diagnose rosacea, to screen inhibitors of th17 differentiation.
11/27/14
20140349330
Methods for aggregation and differentiation of magnetized stem cells
The invention relates to a process which enables optimal aggregation of cells, typically of stem cells, promoting the organisation thereof and advantageously the differentiation thereof, in particular in the context of the formation of a tissue substitute. This process comprises exposing pretreated cells to a magnetic field and makes it possible to obtain large cell aggregates, even prepared in the absence of support matrix and/or of growth factor.
11/27/14
20140349312
In vitro modelling of haematopoietic stem cell medullary nests: a tool for studying the regulation of haematopoiesis, evaluating the nesting potential of a haematopoietic graft and testing the pharmacotoxicology of medicaments
The present invention relates to a culture support for cultivating hematopoietic stem cells (hscs) and/or hematopoietic progenitors (hps), comprising a calcium biomaterial, osteoclasts, endothelial cells and mesenchymatous stem cells (mscs) and/or osteoblasts and/or adipocytes. The present invention also relates to a method for preparing such a culture support, and an in vitro hsc and/or hp cultivation method.
11/27/14
20140349296
Methods of enhancing genetic diagnosis
The present disclosure relates to the use of laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells.
11/27/14
20140348783
Vaccine immunotherapy for immune suppressed patients
A method for overcoming mild to moderate immune suppression includes the steps of inducing production of naive t-cells and restoring t-cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naive t-cells and exposing the naive t-cells to endogenous or exogenous antigens at an appropriate site.
11/27/14
20140348782
Vaccine immunotherapy for immune suppressed patients
A method for overcoming mild to moderate immune suppression includes the steps of inducing production of naive t-cells and restoring t-cell immunity. A method of vaccine immunotherapy includes the steps of inducing production of naive t-cells and exposing the naive t-cells to endogenous or exogenous antigens at an appropriate site.
11/27/14
20140348137
Service differentiation and service level agreements for wireless access clients
Differentiated services are provided through service level agreements (slas) between access nodes and some of the clients using a wireless access network. Client devices include internal devices that are compliant with service-related specifications published by the access nodes.
11/20/14
20140343068
Certain chemical entities, compositions, and methods
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described. Specifically quinoxaline derivatives of formula i and their use in modulating the activity of braf and/or mutant braf kinase to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism are disclosed.
11/20/14
20140343051
Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation
Screening assays to identify compounds that may be useful for inhibiting and/or eliminating aml initiating cells using ahr modulators and/or the compounds of formula i or ii are also disclosed. The use of pharmaceutically acceptable agonists of the ahr for preventing or inhibiting minimal residual disease (mrd) in an aml patient is also disclosed..
11/20/14
20140342452
Islet cells from human embryonic stem cells
This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells.
11/20/14
20140341859
Method for treatment of damaged site of bone
Provided is a treatment method which enables regeneration of bone tissue even when the size of a damaged site of bone is large. The treatment method comprises the steps of: culturing chondrocytes which have been seeded onto a porous body, or differentiating stem cells having chondrogenic differentiation potential which have been seeded onto a porous body into chondrocytes and culturing the chondrocytes; and implanting the porous body having the cultured chondrocytes..
11/20/14
20140341858
Neuron generation, regeneration and protection
The invention demonstrates that, contrary to apoptotic rabies virus g proteins, certain non-apoptotic rabies virus g proteins, such as the g protein of the cvs-niv strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus g proteins, more particularly to their pdz-bs, which shows a single-point mutation compared to the one of apoptotic rabies virus g proteins.
11/20/14
20140341455
Determining petrophysical properties using sodium nuclear magnetic resonance (nmr) logs
The presence of hydrocarbons in a subsurface formation fluid may be inferred from a determined salt concentration. A sodium nuclear magnetic resonance (nmr) measurement of a subsurface formation is obtained and a salt concentration of the fluid in the subsurface formation is determined from the sodium nmr measurement.
11/20/14
20140341381
Loudspeaker noise inspection method, loudspeaker noise inspection device and recording medium for recording a loudspeaker noise inspection program
A loudspeaker noise inspection method is to be implemented by an electronic device and includes the steps of: obtaining a frequency sweeping audio signal from an audio output generated by a loudspeaker in response to a frequency sweeping input signal; performing differentiation upon the frequency sweeping audio signal so as to generate a differentiated frequency sweeping audio signal; and dividing the differentiated frequency sweeping audio signal by a constant which is greater than 2π times a maximum frequency of the frequency sweeping audio signal, so as to obtain an attenuated frequency sweeping audio signal for inspection of a noise pulse in the frequency sweeping audio signal.. .
11/20/14
20140341031
Differentiation of traffic flows mapped to the same bearer
In accordance with an example embodiment of the present invention, an apparatus comprising: at least one processor; and at least one memory including computer program code, wherein the at least one memory and the computer program code are configured to, with the at least one processor, cause the apparatus to perform at least the following: receive at least one traffic flow; establish at least one bearer for communication; assign a first quality of service class identifier value associated with the at least one bearer; map the at least one traffic flow to the at least one bearer; and determine a second quality of service class identifier value for a data packet of the at least one traffic flow.. .
11/20/14
20140341017
Differentiation of traffic flows for uplink transmission
In accordance with an example embodiment of the present invention, an apparatus comprising: at least one processor; and at least one memory including computer program code, wherein the at least one memory and the computer program code are configured to, with the at least one processor, cause the apparatus to perform at least the following: receive at least one traffic flow; receive at least one quality of service indication associated with the at least one traffic flow; create binding of the received at least one quality of service indication and information associated with the received at least one traffic flow; and assign a quality of service indication to a data packet for transmission based at least in part on the created binding.. .
11/13/14
20140336443
Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use
This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
11/13/14
20140336275
Modular emulsion-based product differentiation
A micro-scale heterogeneous emulsion is provided. In some examples, the micro-scale heterogeneous emulsion can include at least two internal phases and an external phase.
11/13/14
20140336239
Compositions and methods for modulating myeloid derived suppressor cells
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (mdsc). In particular, described herein are mir-142 polynucleotides and mir-223 polynucleotides that can be used to modulate differentiation of mdscs.
11/13/14
20140336220
Composition for preventing or treating obesity comprising rebamipide
The present disclosure relates to a composition and a health functional food for preventing or treating obesity comprising a rebamipide compound or its pharmaceutically acceptable salt as an active component. It is confirmed that when a rebamipide compound of the present disclosure is administered to a mouse model induced with obesity, it shows excellent effects of reducing weight, reducing adipocyte, and reducing a total cholesterol content in the body, as compared with a non-administered control group, and also, it shows an excellent effect of suppressing differentiation of cytotoxic th17 cells that generate and secrets inflammatory cytokine and an excellent effect of improving activity of regulatory t cells (treg) capable of suppressing a function of abnormally activated immune cells and controlling an inflammatory reaction.
11/13/14
20140336074
Method for preparing improved cardiomycocyte-like cells
The present invention relates to the field of cell differentiation. In particular, the present invention relates to a method for preparing improved cardiomyocyte-like cells differentiated from at least one multipotent or pluripotent cell, comprising a step of contacting the cardiomyocyte-like cell(s) with at least one agent to promote and/or induce integrin subunit alpha-v (integrin αv) activity, thereby modulating expression of at least one cardiac gene of said cardiomyocyte-like cells.
11/13/14
20140335615
Methods of using mechanical force with somatic and pluripotent cells
Provided are methods useful in increasing efficiency of biotransport, reprogramming or altering a cell's state of differentiation, and maintenance of cells in an undifferentiated state.. .
11/13/14
20140335590
Methods for promoting cell reprogramming
The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency.
11/13/14
20140335059
Stem cell-derived neural cells for cell therapy in neurological disorders
The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided..
11/13/14
20140335030
Modular emulsion-based product differentiation
A micro-scale heterogeneous emulsion is provided. In some examples, the micro-scale heterogeneous emulsion can include at least two internal phases and an external phase.
11/06/14
20140330568
System and method for auditory captchas
Disclosed herein are systems, methods, and computer readable-media for performing an audible human verification. The method includes determining that a human verification is needed, presenting an audible challenge to a user which exploits a known issue with automatic speech recognition processes, receiving a response to the audible challenge, and verifying that a human provided the response.
11/06/14
20140330119
Identifying abnormal tissue in images of computed tomography
An imaging method for identifying abnormal tissue in the lung is provided, comprising the recording of slice images of the lung by means of x-ray radiation, recording of blood vessels, differentiation of blood vessels and abnormal tissue, segmentation of the abnormal tissue and display of the segmented abnormal tissue on an output device. In addition, a computer tomograph for identifying abnormal tissue in the lung is provided, having a radiation source for recording slice images of the lung and blood vessels by means of x-ray radiation, a computer unit for differentiating the blood vessels from the abnormal tissue and for segmenting the abnormal tissue, as well as an output device for displaying the segmented abnormal tissue.
11/06/14
20140329691
Noninvasive diagnosis of fetal aneuploidy by sequencing
Disclosed is a method to achieve digital quantification of dna (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated.
11/06/14
20140329323
Three-dimensional nanostructured hybrid scaffold and manufacture thereof
A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold.
11/06/14
20140329322
Method of differentiating glioblastoma cells
A method of increasing differentiation of a cell line of glioblastoma cells is disclosed. A platelet-rich plasma (prp) composition is prepared.
11/06/14
20140329321
Methods and compositions for culturing endoderm progenitor cells in suspension
Provided herein are methods for the in vitro differentiation of induced pluripotent stem cells, which have been expanded and/or maintained under defined conditions, into endodermal precursor cells (epcs) that are capable of producing mono-hormonal beta cells.. .
11/06/14
20140329316
Tissue repair with multipotent cells
The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in a human or animal patient using the concept of said method for inducing differentiation of multipotent cells.
11/06/14
20140328831
Single domain tdf-related compounds and analogs thereof
The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
11/06/14
20140328825
Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect
The present invention relates to compositions, kits and methods for making and using rna compositions comprising in vitro-synthesized ssrna inducing a biological or biochemical effect in a mammalian cell or organism into which the rna composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell.
11/06/14
20140328809
Methods of inducing chondrogenesis in mesenchymal stem cells using synthetic triterpenoids
The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies).
11/06/14
20140327900
Distance sensing by iq domain differentiation of time of flight (tof) measurements
A system and method for identifying a position of a moving object, regardless of static objects present in the optical field of an active infrared (ir) proximity detector, is provided. Moreover, a modulated light emitting diode (led) signal is captured and processed through i/q demodulation.
10/30/14
20140324651
Integrated service identity for different types of information exchange services
A service provisioning method includes providing a differentiated set of information exchange services to a user. In some embodiments, differentiation between or among the provided services may include differentiated access networks, differentiated physical network layers, and/or differentiated service providers.
10/30/14
20140323411
Method for de-differentiating a cell
The invention relates to a method for de-differentiating a cell, i.e. The induction of a pluripotent phenotype.
10/30/14
20140322811
Medium composition for rejuvenating stem cells
The present invention relates to a medium composition for transforming stem cells from an aged person into young stem cells, and more particularly to a medium composition for culturing stem cells, which is used to rejuvenate stem cells from an aged person so as to have characteristics similar to those of the stem cells of young people, and to a method for rejuvenating stem cells, which comprises culturing stem cells from an aged person in the medium composition. According to the present invention, even mesenchymal stem cells collected from over 60 years old patients can be transformed into young mesenchymal stem cells having high differentiation ability, high telomerase activity, and high ability to express stem cell markers.
10/30/14
20140322808
Populations of hematopoietic progenitors and methods of enriching stem cells therefor
There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of cd43 and at least one of cd34, cd31 and cd144; and selecting a fraction that is at least one of cd34+cd43−, cd31+cd43− and cd144+cd43−.
10/30/14
20140322359
Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof
The invention relates to a unique formulated pharmaceutical composition and a novel treatment method of intratumoral injection. The pharmaceutical composition of the invention is the saturated ionic solution of sodium ions and calcium ions (the “medicinal ion bomb”).
10/30/14
20140322179
Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns
A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating bone morphogenic protein activity..
10/30/14
20140319609
Finfet drive strength modification
One application of this approach is to enable differentiation of the drive strengths of transistors in an integrated circuit by applying the technique to some, but not all, of the transistors in the integrated circuit. In particular in a sram cell formed from finfet transistors the application of the technique to the pass-gate transistors, which leads to a reduction of the drive strength of the pass-gate transistors relative to the drive strength of the pull-up and pull-down transistors, results in improved sram cell performance..
10/30/14
20140319123
Controller for textile heating device
A controller for use in textile heating devices, such as heating pads, heating blankets, and the like is provided. The controller provides a display system for conveying to a user the selected heat setting.
10/23/14
20140316280
Detection apparatus for determining a state of tissue
The invention relates to a detection apparatus (30) for determining a state of tissue. The detection apparatus (30) comprises a fluorescence spectrum providing unit (2, 3) for providing a fluorescence spectrum of the tissue, a differentiation unit (4) for generating a derivative of the fluorescence spectrum, and a tissue state determination unit (5) for determining the state of the tissue from the derivative.
10/23/14
20140315988
Compositions and methods for reprogramming eukaryotic cells
The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mrna encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mrna that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mrna was introduced, and compositions therefor. For example, the present invention provides mrna molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells..
10/23/14
20140315870
Composition comprising a glucocorticoid and a thiazolidinedione for inducing compelte adipogenic differentiation of mammalian stem cells
The present invention relates to the provision of a composition comprising a glucocorticoid and a thiazolidinedione for inducing adipogenic differentiation, thereby successfully generating functional stem cells, from non-differentiated embryonic or adult stem cells originating from humans or other mammals, special preference being given to human mesenchymal stem cells. The preferred glucocorticoid is dexamethasone and the preferred thiazolidinedione is rosiglitazone.
10/23/14
20140315752
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of stanniocalcin-1, antithrombin-iii, toll-like receptor 2, triiodothyronine (t3), thyroxine (t4), extracellular matrix protein 1, coagulation factor xiii a chain, coagulation factor xiii b chain, interleukin-17f, interleukin-22, vitronectin, progesterone, estradiol, growth/differentiation factor 15, and proprotein convertase subtilisin/kexin type 9 as diagnostic and prognostic biomarkers in renal injuries..
10/23/14
20140315306
Cell culture substrate comprising a laminin and a cadherin
The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells.
10/23/14
20140315305
Method for producing corneal endothelial cell
The invention provides a method of efficiently producing corneal endothelial cells, particularly from corneal stroma or ips cell-derived neural crest stem cells, a method of producing corneal endothelial cells stably in a large amount by inducing more efficient differentiation of stem cells into corneal endothelial cells, and a medicament containing corneal endothelial cells. The method of inducing differentiation of stem cells into corneal endothelial cells includes a step of culturing the stem cells in a differentiation induction medium containing a gsk3 inhibitor (preferably a gsk3β inhibitor) and retinoic acid, with the differentiation induction medium preferably further containing one or more of tgfb2, insulin, a rock inhibitor, and the like..
10/23/14
20140315196
Dna diagnostic screening for turner syndrome and sex chromosome disorders
The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the x and y chromosomes.. .


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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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This listing is a sample listing of patent applications related to Differentiation for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Differentiation with additional patents listed. Browse our RSS directory or Search for other possible listings.
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Key IP Translations - Patent Translations



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