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This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS


Undifferentiated cell detection method and complex carbohydrate detection method

Wako Pure Chemical Industries

Undifferentiated cell detection method and complex carbohydrate detection method

Treatment of myelodysplastic syndrome by inhibition of nr2f6

Treatment of myelodysplastic syndrome by inhibition of nr2f6


Date/App# patent app List of recent Differentiation-related patents
07/30/15
20150212227 
 Downhole differentiation of light oil and oil-based filtrates by nmr with oleophilic nanoparticles patent thumbnailnew patent Downhole differentiation of light oil and oil-based filtrates by nmr with oleophilic nanoparticles
Downhole nuclear magnetic resonance (nmr) methods that utilize oleophilic nanoparticle may allow for differentiation of light oil and oil-based filtrates. For example, a method may involve drilling a wellbore penetrating a subterranean formation using an oil-based drilling fluid that comprises an oil base fluid and a plurality of oleophilic nanoparticles; performing a plurality of nmr measurements at a plurality of depths of investigation (doi) of a near-wellbore portion of the subterranean formation; and producing an invasion profile of an oil-based drilling fluid filtrate into the near-wellbore portion of the subterranean formation based on the plurality of nmr measurements..
Halliburton Energy Services, Inc.


07/23/15
20150204870 
 Undifferentiated cell detection method and complex carbohydrate detection method patent thumbnailUndifferentiated cell detection method and complex carbohydrate detection method
An object of the present invention is to provide a method for evaluating a differentiation status of cells using a culture supernatant of stem cells. Provided is “undifferentiation sugar chain marker” composed of the sugar chain structure “fucα1-2galβ1-3glcnac” or “fucα1-2galβ1-3galnac” and capable of sensitively determining the undifferentiated state of stem cells using a culture supernatant of stem cells.
Wako Pure Chemical Industries, Ltd.


07/23/15
20150203846 
 Treatment of myelodysplastic syndrome by inhibition of nr2f6 patent thumbnailTreatment of myelodysplastic syndrome by inhibition of nr2f6
Methods, compositions, and treatment protocols are provided in the current invention for the treatment of myelodysplastic syndrome (mds) through the inhibition of nr2f6 gene expression or activity of protein. In one embodiment silencing, or substantial inhibition of nr2f6 expression is achieved through induction of rna interference in cells associated with development of mds.

07/23/15
20150203822 
 Method and device for preparing non-embryonic stem cells patent thumbnailMethod and device for preparing non-embryonic stem cells
The invention relates to a process for preparing a non-expanded tissue derivative, that is not subjected to cell proliferation in vitro, which has a vascular-stromal fraction enriched in stem and multipotent elements, such as pericytes and/or mesenchymal stem cells, or for preparing non-embryonic stem cells obtained from a tissue sample or from such tissue derivative, wherein the tissue derivative or such cells are subjected to vibrations derived from a heart sound to control the degree of differentiation or possible differentiation of the stem and multipotent elements into several other types of cells and optimize their potency. The invention relates also to a device for carrying out the process, to stem cells obtainable by the process as well as a drug for the regeneration of an animal tissue..
Lipogems International Srl


07/23/15
20150203818 
 Erythroid production patent thumbnailErythroid production
This invention provides method and media suitable for inducing and supporting the differentiation of stem cells into erythroid cells.. .
University Court Of The University Of Glasgow


07/23/15
20150203809 
 Cell culture patent thumbnailCell culture
The disclosure relates to the fabrication of a three dimensional [3-d] cell culture membrane comprising one or more functionalized surfaces adapted to provide cell culture conditions suitable for the analysis of proliferation, differentiation or function of cells, typically eukaryotic or prokaryotic cells.. .
Centre National De La Recherche Scientifique


07/23/15
20150202256 
 Differentiation marker and differentiation control of eye cell patent thumbnailDifferentiation marker and differentiation control of eye cell
The present invention relates to a differentiation marker and a differentiation controlling technique for an eye cell. More particularly, the present invention has attained an object of providing a differentiation marker for an eye cell among the aforementioned problems, by providing a marker for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, the marker comprising gpr49/lgr5, as well as a detection agent or detection method for identifying a cell having a high proliferation ability among corneal endothelial cells and/or the differentiation ability of a corneal endothelial cell, comprising a substance binding to gpr49/lgr5.
The Doshisha


07/23/15
20150202234 
 Injectable brown adipose microtissues for treatment and prevention of obesity and diabetes patent thumbnailInjectable brown adipose microtissues for treatment and prevention of obesity and diabetes
Provided are methods, pharmaceutical compositions, and kits for treatment of a metabolic condition, including obesity and type 2 diabetes by administration of a therapeutically effective amount of a cell or tissue preparation such as brown adipose microtissues to a subject, where the microtissues comprise adipose stem cells and endothelial cells. Modified approaches to creating brown adipose tissue involve differentiation of explanted white adipose tissue rather than isolation and expansion of adipose stems cells or endothelial cells and formation and differentiation of 3d cell aggregates..
The Trustees Of Columbia University In The City Of New York


07/16/15
20150197726 
 Compounds for improved stem cell differentiation into hepatocytes patent thumbnailCompounds for improved stem cell differentiation into hepatocytes
The invention relates to the compounds of formula i and pharmaceutically acceptable salts and esters thereof, wherein r1-r11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula i as well as pharmaceutical compositions containing such compounds.
Hoffmann-la Roche Inc.


07/16/15
20150196604 
 Agent for treating urinary incontinence including stem cells derived from amniotic fluid patent thumbnailAgent for treating urinary incontinence including stem cells derived from amniotic fluid
The present invention relates to a cell therapy product which is intended for regenerating a sphincter muscle and which contains stem cells derived from amniotic fluid, and more particularly, to a cell therapy product which is intended for regenerating the sphincter vesicae and which contains stem cells derived from amniotic fluid. Also, the cell therapy product of the present invention can be provided in the form of a formulation for administration through injection, said formulation being injected into a hydrogel complex to thereby improve the effects thereof.
Kyungpook National University Hospital


07/09/15
20150192568 

Method and determining degree of stratification and/or differentiation


A method for easily and non-invasively determining a degree of stratification and/or differentiation of cultured cells, and an apparatus for determining a degree of stratification and/or differentiation of cultured cells are provided. The invention relates to a method for determining a degree of stratification and/or differentiation of cultured cells, including: (a) a harvesting step of harvesting a culture solution of the cultured cells; (b) an analytical step of analyzing at least one type of a metabolite of the pentose phosphate pathway and/or the tca cycle in the culture solution; and (c) a determination step of referring to a database of correlations between prospectively-obtained degrees of stratification and/or differentiation of the cultured cells and analytical results of metabolites, for analytical results obtained in the analytical step, to determine the degree of stratification and/or differentiation of the cultured cells..
Hitachi, Ltd.


07/09/15
20150191744 

Cas9 effector-mediated regulation of transcription, differentiation and gene editing/labeling


The present disclosure relates to methods of and systems for modifying the transcriptional regulation of stem or progenitor cells to promote their differentiation or reprogramming of somatic cells. Further, the labeling and editing of human genomic loci in live cells with three orthogonal crispr/cas9 components allow multicolor detection of genomic loci with high spatial resolution, which provides an avenue for barcoding elements of the human genome in the living state..
University Of Massachusetts


07/09/15
20150191700 

Differentiation of human embryonic stem cells


The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides a method to increase the expression of markers associated with the pancreatic endocrine lineage..
Janssen Biotech, Inc.


07/09/15
20150191699 

Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof


The disclosure provided herein relates generally to mesenchymal-like stem cells “hes-t-misc” or “t-msc” and the method of producing the stem cells. The method comprises culturing embryonic stem cells under conditions that the embryonic stem cells develop through an intermediate differentiation of trophoblasts, and culturing the differentiated trophoblasts to hes-t-msc or t-msc, t-msc derived cells and cell lineages “t-msc-dl” are also described.
Imstem Biotechnology, Inc.


07/09/15
20150191698 

Adipose-derived stem cells and lattices


The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells.
University Of Pittsburgh Of The Commonwealth System Of Higher Education


07/09/15
20150191697 

Cardiomyocyte production


Methods and composition for the production of cardiomyocytes from differentiation of pluripotent stem cells are provided. For example, in certain aspects methods including differentiating pluripotent stem cells in a large volume of suspension culture in the presence of rock inhibitors are described.
Cellular Dynamics International, Inc.


07/09/15
20150191695 

Composition including gelsolin as effective ingredient for inducing differentiation into dendritic cell and inducing differentiation into dendritic cell


Disclosed are a composition including gelsolin as an effective ingredient for inducing differentiation into a dendritic cell, a method of inducing differentiation by using the composition, and a vaccine composition for treating cancer or an immune-mediated disease. In addition, a composition including gelsolin as an effective ingredient for inducing differentiation into a dendritic cell and a method of inducing differentiation into a dendritic cell by treating an immature dendritic cell with gelsolin are also disclosed.
Korea Institute Of Radiological & Medical Services


07/09/15
20150190547 

Bone matrix compositions and methods


An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier.
Warsaw Orthopedic, Inc.


07/09/15
20150190503 

Methods of using ceo2 and tio2 nanoparticles in modulation of the immune system


Redox-active nps are disclosed that can potentiate innate immunity and stimulate distinct adaptive responses, producing distinct t cell subset polarization outcomes. Nanomaterials that can alter the cellular redox environment through ros modulation can impact human immunology.
Sanofi Pasteur Vaxdesign Corp.


07/09/15
20150190452 

Use of kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function


The present invention relates to a pharmaceutical composition containing kaempferia parviflora wall. Ex.
Industry-academic Cooperation Foundation, Yonsei University


07/02/15
20150188467 

Zero crossing point estimating circuit, motor driving control apparatus and method using the same


A motor driving control apparatus may include: back-electromotive force detecting unit detecting back-electromotive force generated by a motor apparatus; a zero crossing point estimating unit estimating a zero crossing point by performing at least one of differentiation and integration on a voltage difference between the back-electromotive force and a preset reference voltage; and a controlling unit controlling phase switching of the motor apparatus using the zero crossing point.. .
Samsung Electro-mechanics Co., Ltd.


07/02/15
20150186606 

Method and device for indicating differentiation between tissues


The present invention provides a method for indicating differentiation between tissues. For each tissue amongst multiple tissues, a magnetization vector corresponding to each tissue is generated on the basis of a random scan sequence; on the basis of the magnetization vector corresponding to each of the multiple tissues, a differentiation-indicating value between each pair of the multiple tissues is calculated.
Siemens Aktiengesellschaft


06/25/15
20150178307 

Data deduplication using crc-seed differentiation between data and stubs


Various embodiments for differentiating between data and stubs pointing to a parent copy of deduplicated data. Undeduplicated data is stored with a checksum of an initial value.
International Business Machines Corporation


06/25/15
20150175964 

Methods and compositions for the rapid production of retinal pigmented epithelial cells from pluripotent cells


The invention relates to the field of cell culture, specifically, the derivation of retinal pigmented epithelial cells from pluripotent cells. The invention comprises the use of various cell culture medium supplements, medium formulations, and methods of using such medium supplements and formulations, in order to effect the rapid differentiation of pluripotent cells into retinal pigmented epithelial cells with very high yields.
The Regents Of The University Of California


06/25/15
20150175962 

Generating hepatocytes


Compositions and methods are described herein for inducing reprogramming of non-pluripotent cells across lineage and differentiation boundaries to generate endodermal progenitor cells and hepatocytes. Compositions and methods for expansion of endodermal progenitor cells without loss of phenotype are also described herein..
The Regents Of The University Of California


06/25/15
20150175961 

System and method to facilitate the growth of stem cells


A method and system to maintain adult or embryonic stem cells employing 3-d culture conditions is disclosed. Hydrogel scaffolds, composed of hydrophilic polymer networks are provided to emulate a fully hydrated native extracellular matrix and natural soft tissue.
Oakland University


06/25/15
20150175699 

Humanized antibodies to cluster of differentiation 3 (cd3)


Humanized monoclonal antibodies (mabs) or fragments thereof, to human cluster of differentiation 3 (cd3), which confer improved immune stimulation and stability, are disclosed. Pharmaceutical compositions comprising said mabs and methods of treatment and optionally also prevention of diseases and disorders, such as autoimmune disorders, infectious diseases, and transplant rejection, that are susceptible to amelioration by binding to cd3, are also disclosed..
Therapix Biosciences Ltd.


06/18/15
20150170875 

Charged particle beam apparatus


The present invention relates to a defect inspection apparatus based on the fact that contrasts of a grain and a void of a semiconductor copper interconnect in a scanning electron microscope are changed depending on electron beam irradiation accelerating voltages. A charged particle beam apparatus of the present invention irradiates the same portion of a specimen with electron beams at a plurality of accelerating voltages, and differentiates a grain (65, 66) from a void (67) on the basis of a contrast change amount of the same portion in a plurality of images (61, 62) acquired so as to respectively correspond to the plurality of accelerating voltages.
Hitachi High-technologies Corporation


06/18/15
20150169493 

Field unit and a operating an automation system


A field unit with a bus node which is designed for signal conversion between an external bus protocol and an internal bus protocol for communication with at least one function module, in such a way that a sequential transmission of data packets is made along an internal bus system and also including function modules which are designed for processing of data packets and for signal transmission with at least one downstream function component wherein the bus node is so designed for a differentiation of data packets of the higher-level control device that in the bus node a processing of non-safety-related data packets to the internal bus system and onwards transmission of safety-related data packets to the internal bus system is effected, and wherein at least one function module connected to the internal bus system is designed as a safety module for processing of safety-related data packets.. .
Festo Ag & Co. Kg


06/18/15
20150167080 

Method of determining clonotypes and clonotype profiles


The invention is directed to methods for determining clonotypes and clonotype profiles in assays for analyzing immune repertoires by high throughput nucleic acid sequencing of somatically recombined immune molecules. In one aspect, the invention comprises generating a clonotype profile from an individual by generating sequence reads from a sample of recombined immune molecules; forming from the sequence reads a sequence tree representing candidate clonotypes each having a frequency; coalescing with a highest frequency candidate clonotype any lesser frequency candidate clonotypes whenever such lesser frequency is below a predetermined value and whenever a sequence difference therebetween is below a predetermined value to form a clonotype.
Sequenta, Inc.


06/18/15
20150166961 

Ex vivo expansion of myogenic stem cells by notch activation


Activating notch signaling in cultured canine muscle derived cells inhibited myogenic differentiation, and increased the number of myogenic progenitor cells that were similar to quiescent or newly activated satellite cells. Importantly, cells expanded in the presence of notch activation maintained engraftment potential, indicating the potential for therapeutic benefit.
Fred Hutchinson Cancer Research Center


06/18/15
20150166950 

Pluripotent stem cell culture on micro-carriers


The present invention is directed to methods for the growth, expansion and differentiation of pluripotent stem cells on micro-carriers.. .
Janssen Biotech, Inc.


06/18/15
20150166661 

Anti-cd3 antibodies and methods of use


The invention provides anti-cluster of differentiation 3 (cd3) antibodies and methods of using the same.. .
Genentech, Inc.


06/18/15
20150165203 

Methods of and devices for chemical and threshold-gated electrical neuro-immuno-stimulation that triggers the stem cell growth to restore bodily functions


A method of reducing pain and induce/enhance the stem cell growth/differentiation reaction includes identifying a pair of related noxipoints on an identified muscle/organ and applying a chemical/electrical stimulation to the pair of noxipoints.. .

06/18/15
20150164991 

Method and kit for evaluating and monitoring a treatment program for anemia


The present disclosure relates to methods and kits for evaluating and/or monitoring a treatment program, such as in an anemic subject or in a subject receiving treatment for anemia, including determining a presence or an amount of growth differentiation factor 15 (gdf15) and/or hepcidin in a biological sample from the subject. Further, in some embodiments, the disclosure provides methods and/or kits for treating a disorder of iron homeostasis in a subject, comprising measuring an amount of gdf15 and/or an amount of hepcidin in a sample from a subject and administering iron and/or erythropoietin (epo) to the subject if there is a measurable difference in the amount of gdf15 and/or hepcidin in the sample as compared to a reference amount..
Vanderbilt University


06/18/15
20150164987 

Wnt signaling inhibitor comprising insulin-like growth factor-binding protein


Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of wnt signalling, comprising an insulin-like growth-factor-binding protein (igfbp), the protein being binding to a wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced wnt signalling, comprising the inhibitor of wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof..
National University Corporation Chiba University


06/11/15
20150161307 

Method of designing semiconductor device, designing assistance program, designing apparatus, and semiconductor device


The present invention provides a method of designing a semiconductor device capable of executing a dvfs control which minimizes consumption energy. A consumption power profile p(t) when a known operating voltage and a clock of a known frequency are given to a logic circuit as a dvfs target and a process as a dvfs target is executed is obtained.
Renesas Electronics Corporation


06/11/15
20150159140 

Method for preparing endocrine aggregate of insulin-producing beta cells from human pluripotent stem cells


The present invention prepared insulin-producing endocrine cells by inducing the differentiation of human embryonic stem cells or human induced pluripotent stem cells into definitive endoderm (de), pancreatic endoderm (pe), endocrine progenitors (ep), and endocrine cells (ec) stepwise in that order. Particularly, the present invention established the conditions for the formation of an insulin producing endocrine aggregate (ea) from the endocrine cells.
Korea Advanced Institute Of Science And Technology


06/11/15
20150159139 

Differentiation of human embryonic stem cells


The present invention provides methods to promote the differentiation of pluripotent stem cells. In particular, the present invention provides an improved method for the formation of pancreatic endoderm, pancreatic hormone expressing cells and pancreatic hormone secreting cells.
Lifescan, Inc.


06/11/15
20150159137 

Adjuvant for rapid proliferation of human mesenchymal stem cells in vitro, rapid proliferation of human mesenchymal stem cells in vitro, growth factor harvested from rapid proliferation of human mesenchymal stem cells in vitro and use thereof


An adjuvant for rapid proliferation of human mesenchymal stem cells in vitro is provided to overcome the problem of low cell amplification efficiency of human mesenchymal stem cells in a culture process. The adjuvant added for the culture of human mesenchymal stem cells includes at least one antioxidant, and a basic fibroblast growth factor (fgf-2).
Buddhist Tzu Chi Medical Foundation


06/11/15
20150159133 

Method of in vitro differentiation of motor neuron progenitors (mnps) from human induced pluripotent stem cells and cryopreservation of mnps


Methods are disclosed for the initiation and differentiation of human embryonic stem cells (hescs) and induced pluripotent stem cells (ipscs) into motor neuron progenitor cells (mnps). Methods are also disclosed for the cryopreservation of mnps.
Lonza Walkersville, Inc.


06/11/15
20150159132 

Technology for cell transdifferentiation


This invention provides technology for transdifferentiating cells from one cell type to another. The cells are cultured with one or more vector-free gene regulator oligonucleotides concurrently or in succession, and then harvested when cell markers or the morphology of the culture shows that transdifferentiation is complete.
Fluidigm Corporation


06/11/15
20150159131 

Methods and compositions for regulating musashi function


The invention generally features compositions and methods for detecting and regulating cell proliferation, potentiation, and differentiation in a population of cells. In particular, compositions and methods are provided for modulating the activity of musashi proteins.
Board Of Trustees Of The University Of Arkansas


06/11/15
20150158840 

Compounds for improved stem cell differentiation into hepatocytes


The invention relates to the compounds of formula i and pharmaceutically acceptable salts and esters thereof, wherein r1-r11 are as defined in the description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula i as well as pharmaceutical compositions containing such compounds.
Hoffmann-la Roche Inc.


06/11/15
20150157675 

Composition comprising eupatorium spp. extract as active ingredient for preventing and treating obesity and metabolic bone disease


The present invention relates to a eupatorium spp. Extract having anti-obesity effects as a result of decreasing adipocytes and increasing osteoblasts, as well as the effects of preventing bone disease or fractures by increasing osteoblasts and of preventing osteoporosis by decreasing adipocytes and increasing osteoblasts by the same proportion in mesenchymal stem cells.
Republic Of Korea (management:rural Development Administration)


06/11/15
20150157663 

Pharmaceutical composition comprising human-blood-derived-cell mass


There are provided a pharmaceutical composition for treating immune-related diseases, a pharmaceutical composition for treating ischemic diseases, a pharmaceutical composition for promoting lymphangiogenesis, a pharmaceutical composition for treating neurological diseases, a pharmaceutical composition for treating metabolic diseases, and the like, which contain blood-born hematospheres, and more specifically, may differentiate into inflammatory mononuclear cells, vascular endothelial cells, vascular smooth muscle cells, lymphatic vessel adult stem cells and progenitor cells, neural progenitor cells and nerve cells, insulin secreting cells, and the like by effective 3d culturing using blood mononuclear cells. Therefore, the present invention is expected to be used for development of a cell therapeutic agent for various types of diseases.
Snu R&db Foundation


06/04/15
20150153324 

Non-invasive measuring proliferation and differentiation state of cells by using magnetic resonance spectroscopy, and cell proliferation and differentiation marker for magnetic resonance spectroscopy used therefor


Provided are a noninvasive measurement of cell signals and a method thereof, wherein the measurement method can ascertain cell proliferation and differentiation states using mrs and can enable cells to be reused so that cell states can be evaluated with improved reproducibility and reliability. And since the cell signals are noninvasively measured using the mrs, the corresponding cells can be reused so that the cost and time needed for one experiment can be remarkably reduced..
Inje University Industry-academic Cooperation Foundation


06/04/15
20150152176 

Antagonist antibodies against gdf-8


The disclosure provides novel molecules related to growth and differentiation factor-8 (gdf-8), in particular mouse and humanized antibodies, and antibody fragments, including those that inhibit gdf-8 activity and signaling in vitro and/or in vivo. The disclosure also provides methods for diagnosing, treating, ameliorating, preventing, prognosing, or monitoring degenerative orders of muscle, bone, and insulin metabolism, etc., in particular amyotrophic lateral sclerosis (als).
Wyeth Llc


06/04/15
20150150983 

Intra-articular formulations and methods for treatment of osteoarthritis


Intra-articular formulations and methods are provided for treating joint conditions, such as osteoarthritis. The formulations include an effective amount of recombinant human growth differentiation factor-5 (rhgdf-5) and an acidic vehicle, where the formulation is an intra-articular injection formulation.
Depuy Mitek, Llc


06/04/15
20150150951 

Pharmaceutical composition comprising bee venom-phospholipase a2 (bv-pla2) for treating or preventing diseases related to degradation of abnormal regulatory t cell activity


The present invention relates to a pharmaceutical composition for treating or preventing a disease related to abnormal suppression of regulatory t cell activity comprising a polypeptide comprising a bee venom-pla2 amino acid sequence exclusive of a leader sequence as an active ingredient. The secretory bee venom-phospholipase a2 of the present invention activates a regulatory t cell and suppress a differentiation of th1/th7.

06/04/15
20150150681 

Tissue repair devices and scaffolds


The present invention relates to multiphasic, three-dimensionally printed, tissue repair devices or scaffolds useful for promoting bone growth and treating bone fracture, defect or deficiency, methods for making the same and methods for promoting bone growth and treating bone fracture, defect or deficiency using the same. The scaffold has a porous bone ingrowth area containing interconnected struts surrounded by a microporous shell.

05/28/15
20150150123 

Coordinated detection and differentiation of denial of service attacks


According to one embodiment, an analyzer module (am) within a same protected network and on-premise with a web application server (was) detects and distinguishes between types of denial-of-service (dos) attacks. The am tracks whether test http messages, which include test http request messages that a signal generation module (sgm) is configured to transmit to the was and test http response messages that the was is expected to transmit in response to the test http request messages, are timely received.
Imperva, Inc.


05/28/15
20150149106 

Field triage of eos failures in semiconductor devices


Automated test procedures, carried out under software control, can be employed to test a device, testing individual pins, and/or groups of pins, to detect and diagnose or characterize various types of failures. A distributed fa system includes a shared database for device definitions, test setups, and test results.
Teseda Corporation


05/28/15
20150148356 

Compounds for dry skin and anti-ageing application


The present invention relates to the cosmetic use, as agent for preventing and/or treating an aesthetic defect in the skin and/or its appendages that is associated with an imbalance in the differentiation and/or proliferation of the cells of an epidermis, of an effective amount of at least one compound represented by one of the general formulae, (ia) or (ib). .
L'oreal


05/28/15
20150147807 

High-throughput image-based chemical screening in zebrafish blastomere cell culture


Disclosed are methods of inducing differentiation of stem into myogenic cells without gene manipulation and for inducing proliferation of satellite cells. The cells can be used as a source of cells for transplantation in a subject in need thereof.
Children's Medical Center Corporation


05/28/15
20150147301 

Methods and compositions of producing patient-specific multipotent neuronal stem cells


The present invention relates to the seminal discovery of compositions and a method of producing nsc obtained from stem cells derived from parthenogenically activated human oocytes (phnsc). The phnsc of the invention maintain proliferative and differentiation potential during cultivation and expansion..
International Stem Cell Corporation


05/28/15
20150147290 

Use of g-csf dimer in the treatment of neutropenia


This invention relates to a use of g-csf dimer in the treatment of neutropenia. In particular, the recombinant human g-csf of the present invention can enhance the differentiation and development of neutrophils in animal, and thus effectively reduce the severity of the severe neutropenia and shorten the time of severe neutropenia for the post-chemotherapy cancer patients.
Generon (shanghai) Corporation, Ltd.


05/28/15
20150145512 

Downhole differentiation of light oil and oil-based filtrates by nmr with oleophilic nanoparticles


Downhole nuclear magnetic resonance (nmr) methods that utilize oleophilic nanoparticle may allow for differentiation of light oil and oil-based filtrates. For example, a method may involve drilling a wellbore penetrating a subterranean formation using an oil-based drilling fluid that comprises an oil base fluid and a plurality of oleophilic nanoparticles; performing a plurality of nmr measurements at a plurality of depths of investigation (doi) of a near-wellbore portion of the subterranean formation; and producing an invasion profile of an oil-based drilling fluid filtrate into the near-wellbore portion of the subterranean formation based on the plurality of nmr measurements..
Halliburton Energy Services, Inc.


05/21/15
20150141463 

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.


05/21/15
20150141430 

Method for modulating canonical wnt pathway using folate and inositol


The canonical wnt signaling pathway is implicated in wound healing. Administration of a composition having myo-inositol and folic acid upregulates fibronectin and provides the greatest protection in an additive/synergistic manner against adverse wnt/β-catenin-mediated effects on cell processes relating to cell differentiation, proliferation, and migration that relate to wound healing..
University Of South Florida


05/21/15
20150141352 

Bone loss preventing and bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide


The present invention relates to a bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide, an analogue thereof, a derivative thereof or a pharmaceutically acceptable salt thereof. In contrast to existing passive therapeutic agents which center on bone absorption suppression based on mechanisms for reducing osteoclast functionality, the composition comprising muramyl dipeptide of the present invention promotes the differentiation of osteoblasts, which are bone forming cells, and can advantageously be used in various diseases where bone formation is required as an active therapeutic agent that does not affect osteoclast..
Snu R&db Foundation


05/21/15
20150141289 

Methods and compositions for identifying and validating modulators of cell fate


The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and methods using such cells and constructs.
Chromocell Corporation


05/21/15
20150141268 

Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens


An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample.
Quantum-si Incorporated


05/21/15
20150140661 

Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter


The method for producing a pancreatic hormone-producing cell according to the present invention is characterized in that a specific differentiation/induction promoter is added to a culture medium in the process of differentiating/inducing of a pluripotent stem cell or a pancreatic tissue stem/progenitor cell into the pancreatic hormone-producing cell. The differentiation/induction promoter to be used is: a polypeptide which comprises an amino acid sequence encoded by dna comprising the nucleotide sequence represented by seq id no: 1 or a variant thereof; or a culture supernatant of a cell into which dna comprising the nucleotide sequence represented by seq id no: 1 or dna capable of hybridizing with dna comprising a nucleotide sequence complementary to the aforementioned dna under stringent conditions is integrated as a foreign gene..
Saitama Medical University


05/21/15
20150140658 

Lineage reprogramming to induced cardiac progenitor cells (icpc) by defined factors


Animal cells, notably adult fibroblasts, are advantageously reprogrammed in direct lineage reprogramming methods using defined factors to produce proliferative and multipotent induced cardiac progenitor cells (icpc). The icpc thus produced can be differentiated under suitable differentiation conditions to cardiac lineage cells including cardiomyocytes, smooth muscle cells, and endothelial cells, as evidenced by expression of lineage specific markers.
Wisconsin Alumni Research Foundation


05/21/15
20150140123 

Protein expression analyses for identifying genotoxic compounds


The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal.
Merck Patent Gmbh


05/21/15
20150140016 

Molecular determinants of myeloma bone disease and uses thereof


The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which wnt signaling antagonist inhibits bone differentiation.
Board Of Trustees Of The University Of Arkansas


05/21/15
20150139982 

Anti-siglec-15 antibodies


Antibodies and antigen binding fragments that specifically binds to siglec-15 are described herein. These antibodies or antigen binding fragments may have the ability of inhibiting differentiation of osteoclasts and/or the ability of inhibiting the bone resorption activity of osteoclasts.
Alethia Biotherapeutics Inc.


05/21/15
20150139978 

Novel monascuspurpurones, preparation process thereof, and uses of the monascuspurpurones


Or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of pparγ and/or c/ebpα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided..

05/21/15
20150136430 

Fire suppression systems, devices, and methods


Systems, devices, and methods for determining whether a fire condition exists based on a status of a cooking appliance, and systems, devices, and methods for controlling an exhaust air flow rate in an exhaust air ventilation system based on the status of the cooking appliance. At least one sensor type generating a predefined signal is used to detect fire condition and appliance cooking state, the predefined signal being applied to a controller which differentiates, responsively the predefined signal, in combination with other sensor signals, at least two cooking states each of the cooking states corresponding to at least two exhaust flow rates which the controller implements in response to the controller's differentiation of the two states and which predefined signal is simultaneously used to differentiate a fire condition, in response to the differentiation of which, the same controller activates a fire suppression mechanism..
Oy Halton Group Ltd.


05/14/15
20150134412 

Tools and methods for differentiating child-liking scores in product testing environments


The present disclosure provides tools and methods for improving differentiation in child-liking scores in a product testing environment and/or to improve development of products for child consumers. In an embodiment, tools for differentiating market research scores are provided and include a product rating scale having a plurality of successive scale points and a verbal anchor corresponding to each scale point, and a behavioral list with a plurality of product acceptance behaviors.

05/14/15
20150133520 

Compositions and methods for inducing myoblast differentiation and myotube formation


Provided herein are methods of inducing differentiation of a mammalian myoblast into a mammalian myocyte that include contacting a mammalian myoblast with an oligonucleotide that decreases mitogen-activated protein kinase kinase kinase kinase 4 (map4k4) mrna expression in a mammalian myoblast or myocyte. Also provided are methods of inducing mammalian myoblasts or myocytes to form a myotube that include contacting two or more mammalian myoblasts or two or more mammalian myocytes with an oligonucleotide that decreases map4k4 mrna expression in a mammalian myoblast or myocyte.

05/14/15
20150132853 

Cytoplasmic transfer to de-differentiate recipient cells


Methods for de-differentiating or altering the life-span of desired “recipient” cells, e.g., human somatic cells, by the introduction of cytoplasm from a more primitive, less differentiated cell type, e.g., oocyte or blastomere are provided. These methods can be used to produce embryonic stem cells and to increase the efficiency of gene therapy by allowing for desired cells to be subjected to multiple genetic modifications without becoming senescent.

05/14/15
20150132847 

Encapsulation and cardiac differentiation of hipscs in 3d peg-fibrinogen hydrogels


The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures or tissues can be used in any of a number of protocols including testing chemicals, compounds, and drugs.

05/14/15
20150132846 

Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof


The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.. .

05/14/15
20150132355 

Tdf-related compounds and analogs thereof


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.

05/07/15
20150126884 

System for heart performance characterization and abnormality detection


A system improves analysis, diagnosis and characterization of cardiac function signals (including surface ecg signals and intra-cardiac electrograms) based on cardiac electrophysiological activity momentum computation, characterization and mapping. The system calculates an electrophysiological signal momentum of different portions of cardiac signals including a timing, location and severity of cardiac pathology and improves reliability of diagnosis, detection, mapping to an identified medical condition, and characterization.
Siemens Medical Solutions Usa, Inc.


05/07/15
20150126451 

Tdf-related compounds and analogs thereof, analogs and bioactive fragments


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of tdf-like receptors.
Thrasos Innovation, Inc.


05/07/15
20150125958 

Methods for controlling stem cell differentiation


Disclosed herein are methods for controlling stem cell differentiation through the introduction of transgenes having xic, tsix, or xite sequences to block differentiation and the removal of the transgenes to allow differentiation. Also disclosed are small rna molecules and methods for using the small rna molecules to control stem cell differentiation.
The General Hospital Corporation


05/07/15
20150125953 

Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells


Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating tgfβ, bmp, and fgf signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells.
Indiana University Research & Technology Corporation


05/07/15
20150125506 

Retinal pigment epithelial cells differentiated from embryonic stem cells with nicotinamide and activin a


The present invention concerns rpe cells obtainable by directed differentiation from stem cell, particularly, human stem cells. It has been specifically found that culturing stem cells in the presence of one or more member of the tgfβ superfamily, such as activin a) induced directed differentiation into mature and functional rpe cells.
Hadasit Medical Research Services And Development Ltd.


05/07/15
20150125430 

Compositions and methods for inducing thrombopoiesis


Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with livin, thereby inducing thrombopoiesis.
Hadasit Medical Research Services And Development Ltd.


04/30/15
20150119326 

Administration of angiocidin for the treatment of cancer


Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype..
Temple University Of The Commonwealth Of Higher Education


04/30/15
20150118749 

Retinal pigment epithelial cells differentiated from embryonic stem cells with nicotinamide and activin a


The present invention concerns rpe cells obtainable by directed differentiation from stem cell, particularly, human stem cells. It has been specifically found that culturing stem cells in the presence of one or more member of the tgfβ superfamily, such as activin a) induced directed differentiation into mature and functional rpe cells.
Hadasit Medical Research Services And Development Ltd.


04/30/15
20150118200 

Production of extracellular matrix, conditioned media and uses thereof


Provided is a matrix for promoting survival and differentiation of cells transplanted thereon, comprising a base matrix and a cell-made matrix thereon. Methods and means for making and using same are also provided.
Rutgers, The State University Of New Jersey


04/23/15
20150113545 

Modified jvm with multi-tenant application domains and class differentiation


A method and system for operating a modified java virtual machine (jvm) which is able to simultaneously host multiple java application programs is disclosed. In a first modification the jvm is modified to permit multiple class definitions of some of the java application programming interface (api) classes, so called non-sensitive classes, to be loaded multiple times but ea) restrict other java api classes, so called sensitive classes, to be loaded only once, preferably onto a bootstrap class loader.
Waratek Limited


04/23/15
20150113415 

Method and determining user interface


A method and an apparatus for determining a user interface, which can ensure that a user interface is applicable to a terminal device, and meets a differentiation requirement of the terminal device on a user interface presentation form. The method includes: receiving terminal information sent by a terminal device, where the terminal information includes terminal capability information; determining a first user interface according to the terminal information; and sending the first user interface to the terminal device.
Huawei Technologies Co., Ltd.


04/23/15
20150111828 

Dipeptide mimetics of ngf and bdnf neurotrophins


The invention relates to compounds having either agonist or antagonist activities for the neurotrophins ngf and bdnf and represented by monomeric or dimeric substituted dipeptides that are analogs of the exposed portions of loop 1 or loop 4 regions of these neurotrophins near or at a beta-turn of the respective loop. N-acylated substituents of these dipeptides are biostereoisomers of the amino acid residues preceding these dipeptide sequences in the neurotrophin primary structure.
Uchrezhdenie Rossiiskoi Akademii Meditsynskikh Nauk Nauchno-issledovatelsky Institut Farmakologii


04/23/15
20150111225 

Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof


The present invention relates to a method for in vitro differentiation of a population of blood circulating cells, such as monocytes and preferably pluripotent macrophages derived therefrom, into cells displaying functional and phenotypic neuronal characteristics. The invention further encompasses neuronal-like cells obtainable according to the present method, compositions comprising said cells, and applications thereof..
Assistance Publique - Hopitaux De Paris


04/23/15
20150111218 

Cell differentiation assay method, cell isolation method, producing induced pluripotent stem cells, and producing differentiated cells


Provided are a method for accurately evaluating the differentiation status of stem cells by selectively staining only stem cells in an undifferentiated state, and a method for positively isolating only stem cells in an undifferentiated state. Specifically provided is a method for determining differentiation of a cell comprising a step of contacting a test cell with a probe comprising protein (a) or (b) below and a step of detecting the presence of binding of the probe to the test cell.
Wako Pure Chemical Industries, Ltd.


04/23/15
20150111209 

Gene amplification of coactivator coaa and uses thereof


It has been discovered that amplifications in the gene coactivator activator (coaa) blocks stem cell differentiation and induces cancer stem cells. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to gene amplifications in coaa.



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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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