|| List of recent Differentiation-related patents
|Ex vivo culture, proliferation and expansion of primary tissue organoids|
Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue.
|Bone matrix compositions and methods|
Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity.
|Compositions and methods for dental tissue regeneration|
Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing wnt3a and bmp-7, and optionally vegf, bfgf, or ngf, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and wnt3a and bmp-7, and optionally vegf, bfgf, or ngf..
|Compositions and methods for cancer and cancer stem cell detection and elimination|
In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded rna-specific adenosine deaminases, or adar, enzymes.
|Color x-ray histology for multi-stained biologic sample|
Systems and methods are provided for staining tissue with multiple biologically specific heavy metal stains and then performing x-ray imaging, either in projection or tomography modes, using either a plurality of illumination energies or an energy sensitive detection scheme. The resulting energy-weighted measurements can then be used to decompose the resulting images into quantitative images of the distribution of stains.
|Leveraging biometrics for authentication and touch differentiation|
Biometric authentication and touch differentiation embodiments are described which use a handheld mobile computing device having a signal injection site that injects a signal into a user's hand for a prescribed period of time, and at least one signal sensing site each of which captures a signal emanating from a finger of either of the user's hands that is touching the signal sensing site during at least the period of time the signal is injected. The captured signal or signals are analyzed to determine whether they match, to a prescribed degree, a pre-established signal model that is indicative of a signal or signals expected to be captured.
The present invention provides compounds, compositions and methods for treatment and/or prevention of neurodegenerative diseases, including but not limited to autoimmune diseases, such as multiple sclerosis, in which demyelination, (the loss of the myelin sheath that insulates the nerves) is an associated or causative feature. The data provided demonstrate the utility of the compounds and compositions according to this invention to promote oligodendrogenesis and myelination or remyelination..
|Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza a; influenza b; 2009 influenza a/h1n1; and a 2009 influenza a/h1n1 rna sequence mutation associated with oseltamivir resistance|
Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza a, influenza b, 2009 influenza a/h1n1, and a 2009 influenza a/h1n1 rna sequence mutation associated with oseltamivir resistance.. .
|Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells|
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering.
|Protein markers associated bone marrow stem cell differentiation into early progentior cells|
A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (bm) differentiation into dendritic cells (dc) during in vitro cultivation with the cytokine gm-csf by addition of antisera to an 82 kd bm cell surface protein generating cultivatable dendritic progenitor cells (dp). Genes, methods for preparing them as well as early dp have been provided.
|Method and device for carrying out a signal-processing viewing of a measurement signal that is correlated to the respiratory activity of an individual|
The invention relates to a method and device for carrying out a signal-processing viewing of a measurement signal that is correlated with the respiratory activity of an individual, for example, of a measurement signal that is correlated with the respiratory gas. The aim of the invention is to provide solutions with which an improved electronic analysis of the signals that are representative with regard to respiratory activity can be achieved.
|Bandwidth extension of audio signals|
Audio decoder and method therein for supporting bandwidth extension (bwe) of a received signal. The method involves receiving a first signal representing the lower frequency spectrum of a segment of an original audio signal; receiving a second signal, being a bwe signal, representing a higher frequency spectrum of the segment of the original audio signal.
|Inhibition of c-myc ubiquitination to prevent cancer initiation and progression|
The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of fbw7 e3 ligase inhibitors to inhibit c-myc ubiquitination in cancerous cell populations, such as leukemic initiating cell populations, that are responsible for disease initiation and progression..
|Methods of manipulating the fate of cells|
A method of manipulating the fate of a cell which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding rna species (cur), (b) a modified cur, or (c) a compound that modifies or affects cur, under condition sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of rna:rna or rna:dna or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained.
|Sub-totipotent stem cell product and apparent hereditary modifying label thereof|
Provided are a sub-totipotent stem cell product and epigenetic modification label thereof, a method for inducing the generation of the sub-totipotent stem cell product and identification for the epigenetic modification label of the differentiation potential of stem cells. Also provided is a use of histone modification states of sub-totipotent genes and/or differentiation related genes to predict the epigenetic modification label of the differentiation potentials of stem cells..
|Methods of inducing differentiation of stem cells|
The present invention relates to methods of inducing differentiation of stem cells. In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells.
|Method for observing stem cells, method for removal of cell region in state tending toward differentiation, and device for observing stem cells|
A method for observing stem cells by an observation device 1 comprises, placing stem cells c in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light l1 into the waveguide 21 and emitting the illumination light l1 to the stem cells c in the petri dish 11 via the water 13, and detecting scattered light l2, the scattered light l2 being the illumination light l1 emitted to the stem cells c that is scattered by the stem cells c and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light l2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation..
|Ceramidase and cell differentiation|
The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders. Each of these methods involves treating a cell population with, and/or culturing a cell population in, a ceramidase.
|Isolated liver stem cells|
Isolated liver progenitor stem cells and cell populations of isolated liver progenitor stem cells are disclosed. The progenitor stem cells originate from adult liver, especially human adult liver.
|Uses of growth and differentiation factor 8 (gdf-8)|
The present invention relates to uses of growth and differentiation factor 8 (gdf-8) in vitro or in vivo for reducing the immunogenicity or risk of rejection of cells such as in particular mesenchymal stem cells (msc), tissues or materials. The present invention further relates to methods for differentiating msc in vitro or ex vivo into osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells using fgf-2 and gdf-8.
|Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same|
The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.. .
|File differentiation based on data block identification|
A memory system or flash card may include an algorithm for identifying and accounting for the rewrite frequency of data to be written to the card. The file system partition or file type of data may be used for monitoring rewrite frequency and predicting future rewrites.
|System and method for identification of breast ductal network|
An imaging system induces an increased visibility of the fluid-containing ducts of the breast to enhance the imaging of the ducts, to improve differentiation of the ducts from the surrounding tissue and to detect lesions present within the duct. The imaging system includes a noninvasive fluid visibility increasing module configured for increasing the visibility of a fluid contained within one or more ducts of the breast and an increased fluid visibility detector configured for detecting the one or more ducts having increased fluid visibility to identify the one or more ducts within the ductal system of the breast.
|Method for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof|
The present invention is for method of treating metabolic bone disease, new compounds and pharmaceutical compositions comprising the active ingredients having inhibition effects on osteoclast differentiation. The pharmaceutical composition comprising new compounds according to the present invention can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and paget's disease..
|Methods of treating or preventing overweight and obsesity in mammals by administering a composition comprising mannoheptulose|
The present invention is based on the discovery that mannoheptulose (mhep) reduces or inhibits the differentiation process of fat stem cells into adipocytes so as to decrease the body's fat storage capacity. Compositions comprising a mhep, process of making the compositions, and methods of using the compositions for treating or preventing overweight and obesity in a mammal, such as, for example, a growing pet (e.g., puppy, kitten), or a spayed/neutered pet, are encompassed by the present invention..
|Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions|
Methods and compositions for differentiating pluripotent stem cells into cells of endothelial and hematopoietic lineages are disclosed.. .
|Neural progenitor cell differentiation|
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ecm) compositions, such as collagen i, iv, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ecm compositions.
|Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof|
The invention generally relates to human biology discoveries and therapeutic and diagnostic compositions and methods based thereon. More particularly, the invention relates to human homeobox gene ventx and its control of macrophage terminal differentiation and activation, and related therapeutic and diagnostic compositions and methods of use, in particular in connection with inflammatory diseases..
|Compositions and methods for mesenchymal and/or chondrogenic differentiation of stem cells|
Chondrocytes and compositions including chondrocytes produced via methods that do not require the formation of embryoid bodies are disclosed herein. The cells and compositions disclosed herein are suitable for use in treating osteoarthritis and other cartilage disorders or injury, as well as for tissue regeneration, particularly cartilage regeneration..
|In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (pec) and endocrine cells|
A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described.
|Input differentiation for touch computing devices|
Methods for differentiating touch inputs are disclosed. A method detects a touch input by receiving contact at a computing device's touch surface and identifies whether the touch input was received from a stylus based on additional input received from the stylus.
|Bicycle differentiation using video data analytics|
A vehicular observation and detection apparatus and system incorporates a detection framework using video analysis to differentiate between motorized vehicles and bicycles for improved traffic flow and safety at intersections. The detection framework creates virtual zones overlaid on lanes of a roadway and analyzes input data representing objects in the virtual zones collected from one or more cameras positioned at or near the roadway..
|System and method for adhesive application of a customized sole-shaped pad|
Systems, methods, and computer-readable storage media for applying an adhesive film to the sole of shoes. Application of a portion of the adhesive film can be performed by receiving a shoe on top of the adhesive film, which in turn is above a plate and compressible pins.
|System and method for analyzing hospitality industry data and providing analytical performance management tools|
Hospitality customer acquisition and retention costs are analyzed on a per-channel, channel-agnostic, and aggregated basis. Hotel performance is analyzed by examining net revenue by channel (accounting for each channel's contribution to operating expenses and profits), net revenue in aggregate (via net revpar and revpar capture metrics), and the relative benefit of sales and marketing expenses by quantifying net sales and marketing efficiency.
|Compositions and methods for osteogenic gene therapy|
The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth.
|Small chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound|
A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of es cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of es cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells.
|Method of producing erythrocytes without feeder cells|
Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place..
|Osteoinductive demineralized cancellous bone|
An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone.
|System, apparatus, and method for enhancing stereoscopic images|
The ability of some people to perceive simulated stereoscopic images or even actual stereoscopic images can be enhanced by treating the two eyes differently. The disclosed system can enhance stereoscopic images by selectively modifying the incoming images using right/left differentiation filter.
|Systems, apparatus, and methods for providing continuous-time signal differentiation and integration|
Systems and methods for providing an approximate differentiation and integration of an input continuous-time signal are provided. The disclosed systems include a continuous-time delay block configured to receive an input continuous-time signal and to delay the input continuous-time signal by a predetermined delay factor to generate a delayed input continuous-time signal, a processing block configured to determine a difference or a sum between two continuous-time signals, and a multiplication block configured to multiply an input continuous signal to provide a multiplied input continuous signal..
|Compositions and methods for restoring the stratum corneum and treating dermatological diseases|
The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to restore the stratum granulosum and stratum corneum and treat a dermatological disease, such as, for instance atopic dermatitis. More specifically it provides terpenes and terpenoids such as monoterpenoids, sesquiterpenes and norisoprenoids as ingredients that work to restore and thicken the stratum granulosum and stratum corneum and treat a dermatological disease.
|Malignant and non-malignant disease treatment with ras antagonists|
The present disclosure describes new inhibitors or antagonists of ras useful for the treatment of conditions resulting from ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition.
|Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells|
An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene.
|Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors|
Methods for expanding proliferating populations of neuronal subtype-specific progenitors are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors..
|Cytoplasmic stain composition|
A composition of two cytoplasm stains for use in differentiation of cell nuclei from cell cytoplasmic components and differentiation of specific cytoplasm components by tinctorial contrast. Specifically, the invention relates to two stain compositions utilized as a counter stain in the hematoxylin and eosin procedure for use in histological and cytological microscopic evaluation of tissue and cells.
|Methods and devices for intraoral tactile feedback|
The present invention is directed to methods and devices for teaching the proper configuration of the oral articulators, particularly the tongue, corresponding to particular speech sounds by providing intraoral tactile feedback. Intraoral tactile feedback is achieved by placing nodes in the oral cavity of the patient in locations corresponding to the proper lingual position required to produce a target sound.
|Gamma-diketones as wnt/beta -catenin signaling pathway activators|
The present disclosure provides γ-diketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .
|Novel peptide derivatives for treatment, prevention or alleviation of a condition associated with bone loss or low bone density or to inhibit osteoclast differentiation and stimulation|
Compounds of formula r1-a-nh—ch(r2)—co—r3 are presented. The compounds can be used to treat or alleviate conditions associated with bone loss or low bone density, or to inhibit osteoclast differentiation and stimulation, bone resorption and/or loosening of a prosthetic device.
|Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells|
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation.. .
|Neural progenitor cell populations|
This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population.
|Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject|
In one aspect, the present invention relates to methods for increasing, decreasing or maintaining the innate immune response in a mammalian subject comprising modulating the expression of dux4-fl, or modulating the expression of beta-defensin 3 (defb103). In another aspect, the present invention relates to methods for increasing, decreasing or maintaining myogenesis or muscle differentiation in a mammalian subject comprising modulating the expression of beta-defensin 3 (defb103).
|Method for using directing cells for specific stem/progenitor cell activation and differentiation|
A method is provided, including obtaining a population of antigen-presenting cells, enriching a population of stem/progenitor cells within a larger population of cells, activating the population of antigen-presenting cells and, following the activating, inducing at least one process selected from the group consisting of: differentiation, expansion, activation, secretion of a molecule, and expression of a marker, by exposing the enriched stem/progenitor cell population to the population of antigen-presenting cells. Other applications are also described..