This page is updated frequently with new Differentiation-related patent applications.
| Composition for inducing differentiation of multipotent neural stem cells into dopaminergic neurons and inducing differentiation of multipotent neural stem cells into dopaminergic neurons by using the same|
Disclosed is a composition for inducing the differentiation of neural stem cells into dopaminergic neurons. The composition includes the compound represented by formula 1 (“as703026”) as a mek 1/2 inhibitor.
Industry-academic Cooperation Foundation, Yonsei University
| Compositions and methods for modulating hexm1 expression|
The potency of a series of hexamethylene bis-acetamide (hmba) derivatives of formula i, that induce hexamethylene bis-acetamide inducible protein 1 (hexim1) was determined in cancer cells. The method of inducing hexim1 expression and cell differentiation in cancer and hiv cells are disclosed.
Case Western Reserve University
| Non-human animals having a humanized cluster of differentiation 47 gene|
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an endogenous cluster of differentiation (cd) gene, in particular a humanization of a cd47 gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous cd47 gene so that said non-human animals express a cd47 polypeptide that includes a human portion and a non-human portion (e.g., a murine portion)..
Regeneron Pharmaceuticals, Inc.
|Multiband wireless data transmission between aircraft and ground systems|
Provided are methods and systems for multiband wireless data transmission between aircraft and ground systems. The transmission uses different wavelength ranges, each wavelength range corresponding to a different data domain and establishing a different communication channel.
The Boeing Company
|Lock detection circuit, oscillation source circuit and wireless device|
A lock detection circuit includes: a phase difference detection circuit that detects a phase difference between a divided signal of an oscillation signal and a reference signal; a differentiation circuit that calculates a second differential value and a third differential value of the phase difference; and a synchronization detect circuit that detects the reference signal synchronizes with the oscillation signal, based on the secondary differential value and the third differential value.. .
|Single source dual energy having two filters for x-ray spectrum differentiation in the case of radiator screens having slotted plates|
A slotted plate is for limiting an incident x-ray radiation. The slotted plate includes at least one slotted opening and two different x-ray filter regions for x-ray spectrum differentiation of the incident x-ray radiation.
Siemens Healthcare Gmbh
|Methods for testing t cell priming efficacy in a subject|
The present invention relates to methods for testing t cell priming efficacy in a subject. In particular the present invention relates to an in vitro method for testing t cell priming efficacy in a subject comprising the steps of a) providing sample from the subject, b) culturing the sample in a medium which induces the differentiation of dendritic cells, c) maturing the dendritic cells obtained at step a) in presence of an amount of at least one antigen and an amount of at least one cytokine or ligand suitable for the activation of a pathogen recognition receptor, d) priming and expanding the t cells present in the sample and e) analyzing the func tionality of the primed t cells..
UniversitÉ Paris - Sud
|Culture medium for stem cell differentiation|
Media for the culture of pluripotent stem cells and differentiation of cardiomyocytes, and methods of using this media to produce cardiomyocytes. These media and methods can support cloning, differentiation and induced pluripotent stem (ips) cell derivation..
The Usa, As Represented By The Secretary, Dept. Of Health And Human Services
|Compositions and methods for inducing differentiation of stem cells|
Compositions and methods for inducing differentiation of stem cells such as cancer stem cells (cscs), and increasing sensitivity of cscs to at least one oxidizing agent in a subject include sulindac and/or epimers thereof. These sulindac-based compositions and methods are particularly useful for treating cancers such as glioblastoma (gbm) and for differentiating stem cells in vitro that can be used for cell replacement therapy in a subject in need thereof..
|Definitive endoderm cells and human pluripotent stem cells|
Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.. .
Pluripotent stem cell expansion and passage using a rocking platform bioreactor
Provided herein are novel methods for expansion and passaging of cell aggregates comprising stem cells and/or differentiated cells and comprising the use of closed systems on rocking platform bioreactors. The methods of the invention permit closed system serial passage expansion of pluripotent stem cells and/or progeny thereof with associated pluripotency markers and differentiation potential..
General Electric Company
Antibodies to human gdf8
The present invention provides isolated human or humanized antibodies or antigen-binding fragments thereof which specifically bind to growth and differentiation factor-8 (gdf8) and block gdf8 activity. The antibodies and antibody fragments of the present invention may be used in therapeutic methods for treating conditions or disorders which are ameliorated or improved by inhibition of gdf8..
Regeneron Pharmaceuticals, Inc.
Method and device for bioengineering bone tissue and modulating the homeostasis of osteogenesis
The disclosure is directed to a device and method of treating bone formation disorders or conditions by bioengineering a targeted bone tissue and modulating the homeostasis of osteogenesis and bone resorption by a localized delivery of peripheral blood mononuclear cells and/or hematopoietic stem cells, and/or cells, such as osteoclasts, obtained by the ex vivo differentiation of these cells. A therapeutic strategy, as well as a device to deliver the therapeutic strategy, is described herein..
Multispectral light source
Medical illumination systems and devices for illuminating a target surgical area with a pre-selected type of multispectral light to aid tissue differentiation as viewed by the human eye, especially in open-surgery settings, and methods for practicing the same. A light source may have multiple settings selectable to provide various types of multispectral light configured to reduce reflection from corresponding tissue types relative to full-spectrum light.
Linear light source, optical sensor, differentiation unit, and automatic transaction apparatus using the same
[solution] a linear light source including an ultraviolet light emitting diode (1a), a visible light emitting diode (3a), and a light guide (5). The ultraviolet light emitting diode (1a) and the visible light emitting diode (3a) are disposed at least at one end in an optical axis direction of the light guide (5), and are disposed with an optical axis shifted and by providing a level difference in the optical axis direction.
System and three-dimensional quantitative evaluaiton of uterine fibroids
A system (100) and method which assess the results of uterine fibroid embolization. A fibroid lesion is three-dimensionally segmented by a segmentation module (110) on contrast-enhanced arterial phase mri or cbct images and a differentiation process performed by a subtraction module (114) identifies actual contrast enhancement from background enhancement.
Koninklijke Philips N.v.
Methods and devices for high throughput screening of conditions affecting stem cell differentiation
Disclosed are methods and systems for testing the effects of various morphogens and/or feeder cells on the differentiation of pluripotent cells. The assays described herein can be used for determining the optimum conditions that lead to differentiation of stem cells.
Empire Technology Development Llc
Method for determining differentiation level of pluripotent stem cells
The present invention provides a method for determining differentiation level of pluripotent stem cell, comprising a step of determining a flatness of cultured pluripotent stem cell, wherein the flatness is an indication.. .
Hamamatsu Photonics K.k.
Novel alternative splicing variant of oatp1b3 mrna
According to the present invention, a method for measuring an alternative splicing variant of oatp1b3 mrna in a sample to be examined is provided. Said measurement method comprises measuring mrna comprising a nucleotide sequence represented by seq id no: 1 in the sequence listing table in a sample to be examined isolated from living organism with differentiation from a mrna comprising a nucleotide sequence represented by seq id no: 2.
Methods for forming three-dimensional human retinal tissue in vitro
The present invention relates to the field of stem cells. More specifically, the invention provides methods and compositions useful for forming three-dimensional human retinal tissue in vitro.
The Johns Hopkins University
Anti-fzd10 monoclonal antibodies and methods for their use
The present invention relates generally to anti-fzd10 antibodies and to methods of using anti-fzd10 antibodies. In particular, the anti-fzd10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of fzd10, including as stand-alone therapies and in combination therapies with other agents..
Pro-angiogenic peptides and peptide conjugates
Short bioactive sequences derived from the 2nd loop of the 7-transmembranal receptor of endothelial differentiation gene 3 (edg3) useful in stimulation of angiogenesis, and peptide conjugates comprising a permeability enhancing moiety, are provided. Also provided are pharmaceutical compositions comprising the peptides and methods of use in conditions were insufficient blood-supply occurs, or which are associated with endothelia dysfunction such as peripheral vascular diseases, coronary artery diseases, cerebrovascular diseases, diabetes and delayed wound healing, pulmonary disease, eye diseases and pathological condition related to severe infection..
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
Recombinant rift valley fever (rvf) viruses and methods of use
Described herein are recombinant rvf viruses comprising deletions in one or more viral virulence genes, such as nss and nsm. The recombinant rvf viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of rvf virus in livestock and humans.
The Government Of The U.s.a. As Represented By The Secretary Of The Dept. Of Health And Human Servic
Method for improvement of differentiation of mesenchymal stem cells using a double-structured tissue implant
A double-structured tissue implant (dsti) and a method for preparation and use thereof for implantation into tissue defects. The double-structured tissue implant for differentiation, growth and transformation of cells, stem cells, mesenchymal stem cells and bone marrow stem cells.
Topology-based method to assess the environmental impact of deicing sodium chloride
An approach is provided for simulating environmental impacts of road salt impact by providing a first-order salt load model that may be run on an information handling system to estimate the spatial differentiation on the environmental impact of road salt in a specified watershed area using only topological information for the specified watershed area. The disclosed salt load model employs a reservoir model to determine the salt loading coefficient c=1/(1+e−λ) for each target point in the landscape, where the topographical index term λ may be efficiently computed by adjusting a topological wetness index term generated by the topmodel runoff generation model to compute the salt loading coefficient c as a two-dimensional map using only topological or elevation data for the watershed area of interest..
International Business Machines Corporation
Air conditioner and controlling the same
An air conditioner (ac) indoor unit includes a housing having an inlet and an outlet; a heat exchanger arranged inside the housing; a blower fan for sucking in air at the inlet to be subject to heat exchange with the heat exchanger, and discharging the heat-exchanged air out of the outlet; and an air flow control device for controlling an air flow discharged from the outlet by sucking in air around the outlet. The ac indoor unit may control the direction of a discharged air flow without a conventional blade structure, thereby increasing an amount of discharged air, reducing circulation noise, and enabling design differentiation..
Samsung Electronics Co., Ltd.
Th17 differentiation markers for acne and uses thereof
A method is described for using il-12rβ1/il-23r, ccr6, batf, ahr, stat3, irf4 crucial actors in th17 cells differentiation as markers for acne. Also described are methods of their use to diagnose acne, and to screen inhibitors of th17 differentiation.
Galderma Research & Development
Modeling connections between dopaminergic neurons and the cerebral cortex
Disclosed are methods that include separately differentiating stem cells to form cortical neural progenitor cells and differentiating stem cells to form dopaminergic neural progenitor cells. The cortical progenitor cells are transferred to a first compartment of a culture dish and the dopaminergic progenitor cells are transferred to a second compartment of the culture dish, separated by a removable barrier.
Method for inducing differentiation of pluripotent stem cells into endodermal cells
A synthetic peptide having a stem cell differentiation-inducing activity to induce differentiation of pluripotent stem cells into endodermal cells, a stem cell differentiation inducer having this peptide as an active ingredient, and a method for inducing differentiation of pluripotent stem cells using these. The synthetic peptide provided by the present invention contains a stem cell differentiation-inducing peptide sequence, and this stem cell differentiation-inducing peptide sequence is selected from an amino acid sequence constituting a signal peptide in any of amyloid precursor proteins (app), amyloid precursor-like protein (aplp) 1 and aplp2, which are known as proteins belonging to the app family, a partial amino acid sequence an amino acid sequence constituting this signal peptide, or a modified amino acid sequence formed by substitution, deletion and/or addition of 1, 2 or 3 amino acid residues in these amino acid sequences..
Toagosei Co., Ltd.
Stem cells derived from pure chorionic trophoblast layer and cell therapy comprising same
The present disclosure relates to stem cells derived from a pure chorionic trophoblast layer (chorionic trophoblast layer without villi, ct-v), which is a part of the tissues of the placenta, and cell therapy comprising same. Stem cells derived from a pure chorionic trophoblast layer according to the present invention exhibit uniform growth characteristic, and superb proliferation and differentiation characteristics compared to the conventional stem cells derived from the whole placenta, and particularly, exhibit excellent differentiation into cartilage cells, thus can be effectively used in cell therapy for treating cartilage damage, deficiency and such, and as a composition for tissue regeneration..
Samsung Life Public Welfare Foundation
Stem cells derived from basal portion of chorionic trophoblast layer and cell therapy comprising same
The present disclosure relates to stem cells derived from the basal portion of the chorionic trophoblast layer (bct), which is a part of the issues of the placenta, and cell therapy comprising same. Stem cells derived from the basal portion of the chorionic trophoblast layer according to the present invention exhibit uniform growth characteristic, and superb proliferation and differentiation characteristic as compared with the conventional stem cells derived from the full placenta or other tissues, and exhibit excellent tissue regeneration effect in an animal model, thus can be effectively used in cell therapy..
Samsung Life Public Welfare Foundation
Cosmetic composition containing hydroxy pyranone derivative compound for promoting differentiation of adipocytes
The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity.
Front-end quality of service differentiation in storage system operations
Systems, methods, apparatuses, and software for data storage systems are provided herein. In one example, a data storage platform includes one or more data storage modules each comprising storage drives coupled over a peripheral component interconnect express (pcie) fabric with at least one processing module that receives storage operations directed to the one or more data storage modules over one or more network interfaces.
Materials and methods for diagnosis and prognosis of liver cancer
The invention relates to materials and methods for diagnosing liver tumor types, and assessing patient prognosis. Specifically, but not exclusively, the invention concerns the determination of marker protein which enable primary liver tumors to be identified and classified according to the latest who classification.
King's College Hospital Nhs Foundation Trust
Nanopore-facilitated single molecule detection of nucleic acids
The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as mirnas.
The Curators Of The University Of Missouri
Composition for preventing or treating osteoporosis, containing progranulin inhibitor as active ingredient
Disclosed is a composition for inducing the differentiation of osteoclasts containing progranulin as an active ingredient, or a composition for the prevention or treatment of osteoporosis containing a progranulin inhibitor as an active ingredient, wherein progranulin functions as an rank-dependent cell-communication factor and as a mediator in osteoporosis through inflammation, and exists at a remarkably high concentration, compared to a control, in the serum of prostate cancer patients, osteoporosis patients, and bedridden patients with low bone mineral density, whereby the progranulin can be used as an osteoclast differentiation factor and as a biomarker for osteoporosis or metastatic prostate cancer.. .
Peptide for promoting osteogenic differentiation or vascularization and use thereof
A peptide has the amino acid sequence of seq id no: 1. The peptide exhibits the activity of a differentiation factor by promoting differentiation by acting on osteoblasts or vascular endothelial cells.
Chonnam National University Hospital
Liquefaction of bone matrix
The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same.
Therapeutic mirnas for treating heart and skeletal muscle diseases
The present disclosure describes the role for mir-322(424)/503 in the differentiation of cardiac precursor cells. Thus, the use of these molecules in the programming of resident stem/progenitor cells into cardiomyocytes, both in vitro and in vivo.
University Of Houston
Drug delivery devices and growth factor formulations for accelerated wound healing
The present invention is directed to novel drug delivery devices and pharmaceutical compositions containing growth and differentiation factor proteins. Said devices and compositions are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues.
Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh
Low shear microfluidic devices and methods of use and manufacturing thereof
Provided herein relates to systems and methods for producing and using a body having a central channel separated by one or more membranes. The membrane(s) are configured to divide the central channel into at least one mesochannel and at least one microchannel.
President And Fellows Of Harvard College
Assay for safety assessment of therapeutic genetic manipulations, gene therapy vectors and compounds
The invention is directed to methods of assessing the safety of therapeutic compounds and therapeutic genetic manipulations, including integrating gene therapy vectors and genome editing. In particular, the invention provides a method, wherein the oncogenic potential of therapeutic compounds and therapeutic genetic manipulations, including integrating gene therapy vectors and genome editing, is determined by determining the percentage of differentiation blocked hematopoietic progenitor cells..
St. Jude Children's Research Hospital, Inc.
Compositions and methods for obtaining stem cell derived lung tissue, and related uses therof
The invention disclosed herein generally relates to methods and systems for converting stem cells into specific tissue(s) or organ(s) through directed differentiation. In particular, the invention disclosed herein relates to methods and systems for promoting definitive endoderm formation from pluripotent stem cells.
The Regents Of The University Of Michigan
Method for obtaining pancreatic endocrine cells from adipose tissue-origin cells
A method of obtaining pancreatic endocrine cells from cells originating in an adipose tissue characterized by comprising culturing the adipose tissue-origin cells; the pancreatic endocrine cells that can be obtained thereby; a method of treating or preventing a disease caused by the hypofunction in pancreatic endocrine cells wherein the above-described pancreatic endocrine cells are used; a method of screening a substance capable of promoting or inhibiting the differentiation into pancreatic endocrine cells characterized by comprising adding a candidate substance to a medium in the course of culturing adipose tissue-origin cells to obtain the pancreatic endocrine cells; and so on.. .
Device and standardizing myoblast differentiation into myotubes
Another aspect of the invention is a method for compounds screening in cell-based assays related to myotoxicity and drug discovery.. .
Three-dimensional model of human cortex
Disclosed herein are methods for differentiation of neuronal cells from stem cells, which produce a three-dimensional model of the neocortex structure. In some embodiments, the methods include culturing stem cells with at least one inhibitor of smad signaling and at least one inhibitor of fibroblast growth factor signaling for a period of time to result in formation of an embryoid body.
New peptide and application thereof
Provided are a new peptide, a vector inserting a dna that codes said peptide, a transformant obtained by transformation with that vector, and applications of said peptide, vector and transformant. The peptide comprises an amino acid sequence set forth in seq id no: 1, or an amino acid sequence obtained by substituting, deleting or adding one or more amino acids to/from the amino acid sequence set forth in seq id no: 1.
Saitama Medical University