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Differentiation patents



      
           
This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS


Date/App# patent app List of recent Differentiation-related patents
08/28/14
20140243349
 Gamma-diketones as wnt/beta -catenin signaling pathway activators patent thumbnailnew patent Gamma-diketones as wnt/beta -catenin signaling pathway activators
The present disclosure provides γ-diketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .
08/28/14
20140243274
 Novel peptide derivatives for treatment, prevention or alleviation of a condition associated with bone loss or low bone density or to inhibit osteoclast differentiation and stimulation patent thumbnailnew patent Novel peptide derivatives for treatment, prevention or alleviation of a condition associated with bone loss or low bone density or to inhibit osteoclast differentiation and stimulation
Compounds of formula r1-a-nh—ch(r2)—co—r3 are presented. The compounds can be used to treat or alleviate conditions associated with bone loss or low bone density, or to inhibit osteoclast differentiation and stimulation, bone resorption and/or loosening of a prosthetic device.
08/28/14
20140242693
 Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells patent thumbnailnew patent Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation.. .
08/28/14
20140242691
 Neural progenitor cell populations patent thumbnailnew patent Neural progenitor cell populations
This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population.
08/28/14
20140242093
 Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject patent thumbnailnew patent Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject
In one aspect, the present invention relates to methods for increasing, decreasing or maintaining the innate immune response in a mammalian subject comprising modulating the expression of dux4-fl, or modulating the expression of beta-defensin 3 (defb103). In another aspect, the present invention relates to methods for increasing, decreasing or maintaining myogenesis or muscle differentiation in a mammalian subject comprising modulating the expression of beta-defensin 3 (defb103).
08/28/14
20140242053
 Method for using directing cells for specific stem/progenitor cell activation and differentiation patent thumbnailnew patent Method for using directing cells for specific stem/progenitor cell activation and differentiation
A method is provided, including obtaining a population of antigen-presenting cells, enriching a population of stem/progenitor cells within a larger population of cells, activating the population of antigen-presenting cells and, following the activating, inducing at least one process selected from the group consisting of: differentiation, expansion, activation, secretion of a molecule, and expression of a marker, by exposing the enriched stem/progenitor cell population to the population of antigen-presenting cells. Other applications are also described..
08/21/14
20140235633
 4-aminoquinazoline derivatives and uses thereof patent thumbnail4-aminoquinazoline derivatives and uses thereof
The present invention provides a 4-aminoquinazoline derivative having the chemical structure of the following formula, and the use thereof. It is demonstrated by the pharmacological experiment that, the compound or a salt thereof according to the present invention not only has distinct inhibitory effect on histone deacetylases, but also has stronger differentiation induction and anti-proliferative activities for certain tumor cells.
08/21/14
20140235542
 Modular, bioactive peptides for binding native bone and improving bone graft osteoinductivity patent thumbnailModular, bioactive peptides for binding native bone and improving bone graft osteoinductivity
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion.
08/21/14
20140235484
 Methods for detection and differentiation of origin of viral dna patent thumbnailMethods for detection and differentiation of origin of viral dna
The invention disclosed herein provides methods for identifying the origin of viral dna in a sample by detecting the methylation state of at least one cpg site on a target site of the genome of a virus of interest, and determining whether the origin of the viral dna is from a cell, such as a tumor cell, or a virion, wherein when the methylation state is positive for methylation, the viral dna is from a cell, and wherein when the methylation state is negative for methylation, the viral dna is from a virion. Use of these methods for diagnosis or monitoring, and/or treatment of a subject infected with a virus known to cause cancer and related disease are also provided..
08/21/14
20140235475
 Th17 differentiation markers for acne and uses thereof patent thumbnailTh17 differentiation markers for acne and uses thereof
A method is described for using ror gamma t or ror alpha to diagnose acne and/or to screen inhibitors of th17 differentiation. Specifically described are methods of inhibiting ror gamma t or ror alpha and use of the screened inhibitors in acne treatment..
08/21/14
20140235236
Service differentiation in a network sharing architecture
In an embodiment, there is provided a method for service differentiation in a network sharing architecture for a mobile network wherein an access network an is shared by different service providers sps, said method comprising at least one step based on an identification of an sp by an sp identity that does not require this sp to own a plmd-id, for service differentiation in said an.. .
08/21/14
20140234971
Induction of hemogenic endothelium from pluripotent stem cells
Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hpscs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hpscs of a combination of transcription factors as described herein.. .
08/21/14
20140234969
Methods for enhancing genome stability and telomere elongation in embryonic stem cells
The disclosure provides methods for increasing genome stability of an embryonic stem (es) cell or induced pluripotent stem (ips) cell, increasing telomere length in an es or ips cell, or both, for example by contacting an es or ips cell with an agent that increases expression of zscan4 in the cell. Methods for increasing genome stability or increasing telomere length in a population of es or ips cells are provided, for example by selecting zscan4+ es or ips cells from the population of es or ips cells (which can include both zscan4+ and zscan4− es or ips cells).
08/21/14
20140234965
Triazine derivatives as differentiation catalysts
A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (i), wherein x is independently —nr4— or —o—, r4 is hydrogen or c1-6-alkyl; r1 is hydroxy, c1-6-alkyl, c1-6-alkoxy, carboxy, c1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, c1-6-alkylamino, or di-c1-6-alkylamino, the c1-6-alkyl or -alkoxy residue being optionally substituted with one or more r5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; r2 is hydrogen, aryl, heteroaryl, or c1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more r1 substituents, and where the c1-6-alkyl is optionally further substituted with one or more r5 substituents; and r3 is selected from hydrogen, halo, nr4r7, or7, sr7, and r7, where the same options apply for r7 as for r2; with the proviso that the compound of formula (i) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.. .
08/21/14
20140234957
Engineered cellular pathways for programmed autoregulation of differentiation
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type.
08/21/14
20140234868
Use for glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medical-plant derived ligand
The present invention relates to glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medicinal-plant-derived ligand acting on lpa1 (lysophosphatidic acid; 1- or 2-acyl-sn-glycerol-3-phosphate), lpa2, lpa3, lpa4 and lpa5 receptors whose efficacy is exhibited physiologically/pharmaceutically via an interaction with subset receptors [lpa1(edg-2), lpa2(edg-4), lpa3(edg-7), lpa4, pla5] in the edg (endothelial differentiation gene) family in g protein-coupled receptors (gpcrs) present in the cell membranes of animals including humans. The gintonin of the present invention can be used to advantage in the prevention and treatment of various diseases arising from reduced calcium concentration and various physiological activities and pharmaceutical activities dependent on calcium, since the gintonin of the present invention interacts with lpa receptors so as to activate a series of signal transmission processes and temporarily induce an increase in free ca2+ in the cytoplasm, and a temporary increase in the intracellular calcium concentration gives rise to a temporary increase in the intracellular calcium concentration in various organs including, inter alia, those of the nervous system, cardiovascular system, endocrine system, reproductive system, digestive system and immune system when the lpa receptors are expressed, with physiological activity being exhibited..
08/21/14
20140234809
Interactive learning system
The present invention provides a system and method for interactively teaching phonics via an electronic device. The present invention enables a user to provide at least two forms of user input: oral and written, and the system recognizes these forms of input to provide feedback and load subsequent content based on user performance.
08/21/14
20140234269
Endometrial derived stem cells and their methods of use
The present invention provides a method of making an insulin-producing cell derived from an endometrial stromal stem cell (essc). The invention includes the progeny of essc, including any cell type generated during the differentiation of essc towards cells that produce insulin and exhibit cell markers characteristic of insulin producing cells.
08/21/14
20140234263
Cellular and molecular therapies
The present invention provides, among other things, improved compositions and methods for the treatment of tissue damage (e.g., acute or chronic) and related diseases, disorders or conditions based on the use of pathfinder cells, extracellular secretomes thereof, and/or pathfinder cell-associated micrornas. In some embodiments, the present invention provides a method for treating tissue damage (e.g., acute or chronic) comprising a step of administering a population of cells to an individual suffering from a disease, disorder or condition characterized by acute damage to one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce tissue repair, regeneration, remodeling, reconstitution or differentiation.
08/21/14
20140234254
Heteroaromatic compounds as pi3 kinase modulators and methods of use
The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (pi3 kinases) and mtor, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
08/14/14
20140230080
Method for inducing hepatocellular variation, and production method for chimeric non-human animal having humanized liver
The present invention provides (1) a method for producing a non-human animal having a humanized liver, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, (2) a non-human animal having a humanized liver, produced by the method, (3) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using the animal, (4) a method for producing human hepatocytes, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, and (5) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using human hepatocytes produced by the method.. .
08/14/14
20140228639
Feature differentiation image capture unit and method in a surgical instrument
In a minimally invasive surgical system, an image capture unit includes a prism assembly and sensor assembly. The prism assembly includes a beam splitter, while the sensor assembly includes coplanar image capture sensors.
08/14/14
20140228289
Modified and stabilized gdf propeptides and uses thereof
Modified and stabilized propeptides of growth differentiation factor proteins, such as gdf-8 and bone morphogenetic protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial.
08/14/14
20140228227
Nanomagnetic detector array for biomolecular recognition
A biomolecular sensor system includes an array of magnetoresistive nanosensors designed for sensing biomolecule-conjugated superparamagnetic nanoparticles. Materials and geometry of each sensor element are designed for optimized sensitivity.
08/14/14
20140227336
Tissue engineering methods and compositions
Cells are employed in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells..
08/14/14
20140227240
Regeneration of spinal discs
Compositions and processes for the effective and efficient regeneration of spinal discs are provided. These compositions contain stem cells, donor cells, and platelet plasma compositions.
08/07/14
20140221982
Semipermeable medical pouches and their uses
A novel process for bacterial production of nanocellulose hydrogel pouches for applications for cell therapy, cell encapsulation, cell delivery, cell proliferation and cell differentiation has been invented. The process is based on fermentation of bacteria producing nanocellulose in oxygen permeable mold interconnected with tubing with diameter less than 5 mm.
08/07/14
20140221648
Th17 differentiation markers for acne and uses thereof
A method is described for using il-12r 1/il-23r, ccr6, batf, ahr, stat3, irf4 crucial actors in th17 cells differentiation as markers for acne. Also described are method of their use to diagnose acne, to screen inhibitors of th17 differentiation.
08/07/14
20140221455
Differentiation modulating agents and uses therefor
The present invention is directed to methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (fgf) signaling pathway, especially the fgf-1 or fgf-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions..
08/07/14
20140221231
Th-17 differentiation markers for rosacea and uses thereof
A method is described that uses ror gamma t, or ror alpha to diagnose rosacea and/or to screen inhibitors of th17 differentiation, notably in inhibiting ror gamma t or ror alpha. Also described is a method of using these screened inhibitors in rosacea treatment..
08/07/14
20140221225
Method for obtaining a multicellular spheroid
The invention provides a method for producing a multicellular spheroid comprising injecting a cell suspension into a gel. The invention also provides a method of producing a gel comprising one or more multicellular spheroids, the method comprising injecting a cell suspension into a gel, as well as a gel obtainable by the method.
08/07/14
20140220604
Troponin and bnp based diagnosis of risk patients and cause of stroke
Method for early differentiation of whether a subject suffers from cardioembolic stroke or from non-cardioembolic ischemic stroke based on the determination of the amount of a cardiac troponin in a sample from a subject who is suffering from ischemic stroke, the sample obtained not more than 24 hours after the onset of symptoms of ischemic stroke. Kits and devices adapted to carry out the methods are also provided..
08/07/14
20140220102
Ectocornea-like sheet and method of constructing the same
It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells.
08/07/14
20140219082
Network congestion control with adaptive qos bit-rate differentiation
A method is provided for congestion control in a network node (114; 510; 700; 900) of a communication network (701). The network node handles a plurality of data connections (dc1−n; rab1−n) for conveying data between a first side and a second side of the communication network.
08/07/14
20140216982
Slide opening display and mail package
An economical package comprising an inner sliding piece assembled inside of one or more outer sleeves, where the inner sliding piece may contain a gift card, loyalty card, product, or promotional messages, and the card, product or messages can be revealed by pulling the inner sliding piece at least partially out of the outer sleeve. The package assembly can provide differentiation, protection, consumer information, and an ability to reuse the package for presentation of the card or information..
07/31/14
20140213477
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of heat shock 70 kda protein 1, alpha-1-antitrypsin neutrophil elastase complex, stromelysin-1:metalloproteinase inhibitor 2 complex, 72 kda type iv collagenase:metalloproteinase inhibitor 2 complex, insulin-like growth factor 1 receptor, myeloid differentiation primary response protein myd88, neuronal cell adhesion molecule, and tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries..
07/31/14
20140212966
Passaging and harvesting formulation and method for human pluripotent stem cells
Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to dislodge cells from cell culture vessels. The formulations and methods permit the harvesting of cells as large clusters from the surface of various cell culture vessels including multilayer cell culture vessels.
07/31/14
20140212887
Screening method for therapeutic agent for chondropathy and modified chondrocyte for treatment of chondropathy
The use of salt-inducible kinase 3 allows screening for a substance having an effect of increasing cartilage volume and/or an effect of normalizing chondrocyte differentiation. A modified chondrocyte in which the expression or function of salt-inducible kinase 3 gene is inhibited or enhanced can be used to ameliorate a disease associated with reduced cartilage volume and/or a disease associated with impaired cartilage growth..
07/31/14
20140212875
Human metabolically active brown adipose derived stem cells
A method of distinguishing a brown adipose cell from a white adipose cell. In one embodiment the method includes measuring the expression level of one or more genes in an adipose cell; comparing the measured expression levels to a control, and correlating the expression level of the one or more genes to an identity as a white adipose cell or a brown adipose cell.
07/31/14
20140212395
Downregulation of mir-7 for promotion of beta cell differentiation and insulin production
A method of ex-vivo increasing insulin content in beta cells or stem cells is disclosed. The method comprising contacting the beta cells or stem cells with an agent for downregulating an activity or expression of mir-7, thereby increasing the insulin content in the beta cells or stem cells..
07/31/14
20140212392
Method of isolating human neuroepithelial precursor cells from human fetal tissue
A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing a2b5, ng2 and encam is provided. In addition, methods for transplanting these cells into an animal are provided.
07/31/14
20140211606
Determining root sequence
It is presented a method, executed in a root sequence determiner for a base station controlling a first cell, the first cell being associated with at least one root sequence used for cell differentiation on a random access channel. The method comprises the steps of: obtaining information on root sequences of neighbouring cells; when a root sequence conflict is found between the first cell and a neighbouring cell, here denoted a conflict cell, determining if the conflict cell is of a higher priority than the first cell, the priorities of the first cell and the conflict cell being based on properties of the respective cells; and when the conflict cell is of a higher priority than the first cell, finding a new root sequence for the first cell, avoiding the root sequences of the neighbouring cells..
07/24/14
20140207623
Price differentiation by market for in-app software purchases
Different prices may be charged for an in-app purchase (iap) for a same item based on a market associated with the user. For example, a user in one market may be charged a different price for an item than what is charged for the item to a user in a different market.
07/24/14
20140207619
System and method for multiple product and price discovery
A system and computer-implemented method are disclosed for optimizing product purchasing to enable consumers to efficiently locate and purchase multiple goods and/or services. A centralized product and price discovery system employs a computer implemented method for determining an optimized purchasing plan using user defined and system defined preferences including the cost of individual products at different locations, product specification differentiation (size, weight, origin of manufacture, user rating), and the cost and/or time to obtain the products from those locations.
07/24/14
20140206022
Three-dimensional cell culture methods for test material assessment of cell differentiation
The present specification discloses three-dimensional in vitro cell-based methods to assess a test matrix polymer ability to support differentiation of a population of cells methods of screening a material for its ability to stimulate cell growth and/or differentiation.. .
07/24/14
20140205602
Antagonist anti-cd40 monoclonal antibodies and methods for their use
Compositions and methods of therapy for treating diseases mediated by stimulation of cd40 signaling on cd40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-cd40 antibody or antigen-binding fragment thereof to a patient in need thereof.
07/24/14
20140205577
Treatment of cardiovascular disorders using the cell differentiation signaling protein nell1
It has been identified in accordance with the present invention that nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a nell1 protein or nucleic acid molecule..
07/17/14
20140201774
Systems and methods for multi-broadcast differentiation
A system and method is disclosed for resolving false positives in a centralized, real-time automatic content recognition system that is ingesting, fingerprinting, and attempting to match for recognition purposes, multiple streams of broadcast content that are simultaneously arriving from a plurality of sources. In particular, the problem of identifying which specific broadcast of certain programming has been matched, including the episode of a series, as well as the channel, time zone and time of broadcast and whether the programing is being watched “live” as broadcast or from a dvr time-shifted source, is addressed.
07/17/14
20140200466
Polymeric materials
Topographical features, such as projections or recesses, having a maximum dimension which is less than 3 μm, with the features being separated by a distance which is less than 10 μm are transferred to polyetheretherketone, on an industrial scale, by injection moulding relatively low viscosity peek, using a mould in which is arranged a master structure which carries the desired topography. The topographical features increase the water contact angle of a surface which includes them and such a modified surface has been shown to influence cell attachment and differentiation.
07/17/14
20140200201
Enzymatic production or chemical synthesis and uses for 5,7-dienes and uvb conversion products thereof
Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet b (uvb) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the p450scc (cyp11a1) or cyp27b1 enzyme systems where the hydroxylase has an activity to hydroxylate position c20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced.
07/17/14
20140200174
Peptide bfp4 for promoting osteogenesis or vascularization and use thereof
Disclosed are a peptide for promoting osteogenesis and vascularization, and the use thereof. The peptide has a low molecular weight so that it can be economically produced.
07/17/14
20140199761
Promoter-regulated differentiation-dependent self-deleting cassette
Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell.
07/17/14
20140199700
Method for producing intestinal cells
An object of the present invention is to provide a method of producing intestinal cells by use of pluripotent stem cells as a starting material. According to the present invention, provided is a method of producing intestinal cells, comprising the steps of: (a) inducing differentiation of pluripotent stem cells into definitive endoderm cells; and (b) culturing the definitive endoderm cells in the presence of (2′z,3′e)-6-bromoindirubin-3′-oxime (bio) and n-[(3,5-difluorophenyl)acetyl]-l-ala-2-phenyl-l-gly-tert-butyl-oh (dapt) to thereby induce differentiation of the definitive endoderm cells into intestinal cells..
07/17/14
20140199327
Methods of promoting differentiation
Provided herein are methods of promoting cell fate change, particularly differentiation of tumor cells, by inhibition of usp1, uaf1, and/or id (e.g., id1, id2, and/or id3).. .
07/17/14
20140199315
Sp35 antibodies and uses thereof
Endogenous sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination (negative regulator). Molecules that block endogenous sp35 function, such anti-sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction.
07/17/14
20140199278
Brown adipocyte modification
Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss.
07/17/14
20140197078
Separation apparatus and separation method
A separation apparatus according to the present invention includes: a conveyor that conveys a group of pieces; a material distinguishing unit that distinguishes between first pieces and second pieces that are placed on the conveyor, according to material; a blower that generates airflow supplied from a middle of the conveyor toward a conveying end along a conveying surface; a first separation unit that blows off the first pieces thrown forward from the conveying end, based on a differentiation result obtained by the material distinguishing unit; a second separation unit that blows off the second pieces toward a different place; and a current plate provided below the group of pieces thrown forward and protruding from the conveyor.. .
07/10/14
20140193909
Direct differentiation of cardiomyocytes from embryonic stem cells
The present invention relates to the induction of differentiation in human embryonic stem (hes) cells to cardiomyocytes and factors such as prostaglandin i2 (pgi2), fgf 9, bmp6, bmp4, scf, igf2, and insulin that influence the process of differentiation to cardiomyocytes. Media that is appropriate for the induction of differentiation of cardiomyocytes from hes cells is also provided wherein the media contains these factors.
07/10/14
20140193904
Pdx1 expressing endoderm
Disclosed herein are cell cultures comprising pdx1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified pdx1-positive endoderm cells as well as methods for enriching, isolating and purifying pdx1-positive endoderm cells from other cell types.
07/10/14
20140193902
Pdx1 expressing endoderm
Disclosed herein are cell cultures comprising pdx1-positive endoderm cells and methods of producing the same. Also disclosed herein are cell populations comprising substantially purified pdx1-positive endoderm cells as well as methods for enriching, isolating and purifying pdx1-positive endoderm cells from other cell types.
07/10/14
20140193895
Automated tissue engineering system
The invention provides systems, modules, bioreactor and methods for the automated culture, proliferation, differentiation, production and maintenance of tissue engineered products. In one aspect is an automated tissue engineering system comprising a housing, at least one bioreactor supported by the housing, the bioreactor facilitating physiological cellular functions and/or the generation of one or more tissue constructs from cell and/or tissue sources.
07/10/14
20140193811
Culture based screening assay and methods of use thereof to identify agents which modulate tumor development, invasion and differentiation
A 3d organotypic culture which phenocopies aggressive, invasive cancer and methods of use thereof are provided.. .
07/10/14
20140193380
Technologies, methods, and products of small molecule directed tissue and organ regeneration from human pluripotent stem cells
Pluripotent human embryonic stem cells (hescs) hold great potential for restoring tissue and organ function, which has been hindered by inefficiency and instability of generating desired cell types through multi-lineage differentiation. This instant invention is based on the discovery that pluripotent hescs maintained under defined culture conditions can be uniformly converted into a specific lineage by small molecule induction.
07/10/14
20140193374
Methods and compositions for culturing cells
The invention provides, among other things, methods and compositions for expanding stem cells. The invention further provides methods, devices and systems for directing differentiation of expanded stem cells.
07/10/14
20140193356
Compositions comprising citrate and applications thereof
In one aspect, methods of promoting bone growth are described herein. In some embodiments, a method of promoting bone growth described herein comprises promoting cell differentiation or phenotype progression in a population of bone cells by providing a citrate-presenting composition to the population of bone cells.


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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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