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Differentiation

Differentiation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and systems for advanced content cacheability determination
Verizon Digital Media Services Inc.
September 14, 2017 - N°20170262767

The embodiments provide systems and methods for efficiently and accurately differentiating requests directed to uncacheable content from requests directed to cacheable content based on identifiers from the requests. The differentiation occurs without analysis or retrieval of the content being requested. Some embodiments hash identifiers of prior requests that resulted in uncacheable content being served in order to set indices within ...
Nt-pro anp and sflt-1 for the differentiation between circulatory and ischemic events
Roche Diagnostics Operations, Inc
September 14, 2017 - N°20170261517

The present disclosure relates to the field of laboratory diagnostics. The present disclosure provides means and methods for differentiating between an acute circulatory event and an ischemic event, as the cause underlying an acute medical event of a patient.
Hand-held measuring device having an nmr sensor and method for the operation thereof
Robert Bosch Gmbh
September 14, 2017 - N°20170261443

A mobile measuring device, in particular a hand-held measuring device, comprises a housing, in which at least one sensor device, a control device for controlling the sensor device, an evaluation device for evaluating the measurement signals supplied by the sensor device as well as a device for supplying energy to the measuring device are provided. The sensor device comprises at ...
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Differentiation Patent Applications
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Method for preparing a three-dimensionally cultured skin comprising dermis and epidermis, and the cultured skin ...
Commonwealth Scientific And Industrial Research Organisation
September 14, 2017 - N°20170260511

The present invention relates to a method for preparing a three-dimensionally cultured skin model comprising dermis and epidermis, which comprises: a step of preparing the dermis using a composition comprising murine fibroblasts; and native collagen or a combination of native collagen and atelocollagen; and a step of forming the epidermis using keratinocytes. Also, the present invention relates to a three-dimensionally ...
Differentiation of hepatocyte-like cells from stem cells
Agency For Science, Technology And Research
September 14, 2017 - N°20170260503

Disclosed are methods of differentiating stem cells in order to obtain hepatocyte-like cells, the method comprising the steps of a) subjecting definitive endoderm to at least one epigenetic modulator to obtain hepatoblasts and b) subjecting the hepatoblasts to at least one stem cell differentiation pathway inhibitor to obtain hepatocyte-like cells; wherein steps a) and b) do not comprise the use ...
Peptide having osteoclast differentiation and activation inhibition, and use of same
Caregen Co., Ltd.
September 14, 2017 - N°20170260233

A peptide which is formed from an amino acid sequence selected from the group comprising amino acid sequences of seq id no: 1 to seq id no: 3, according to the present invention, has osteoclast differentiation and activation inhibition and is highly effective for preventing or treating bone diseases related to the destruction of the bone. A peptide, according to the present ...
Differentiation Patent Pack
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Differentiation Patent Applications
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For professional research & prior art discovery
inventor
  • 383+ full patent PDF documents of Differentiation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Postnatal stem cells and uses thereof
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
September 14, 2017 - N°20170258847

The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to ...
Method for screening induced pluripotent stem cells
Kyoto University
September 07, 2017 - N°20170253934

The present invention provides a method for screening for ips cells exhibiting differentiation resistance using a marker identified as lincrna or mrna that is specifically expressed in an ips cell line exhibiting differentiation resistance, and such markers.
Antibodies against cd73
Bristol-myers Squibb Company
September 07, 2017 - N°20170253665

The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human cluster of differentiation 73 (cd73) with high affinity, and inhibit the activity of cd73, and optionally mediate antibody dependent cd73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, ...
Antitumor derivatives for differentiation therapy
Bristol-myers Squibb Company
September 07, 2017 - N°20170253589

Wherein x is selected from ch, n, s, and o, y is selected from s, co, and o, r1 and optional r2 are independently selected from h, oh, substituted or unsubstituted c1-c6 alkyl, and substituted or unsubstituted c4-c6 cycloalkyl or cycloheteroalkyl, r3 is selected from h, oh, substituted or unsubstituted c1-c6 alkyl, and optional z is selected ...
Protein-chaperoned t-cell vaccines
Massachusetts Institute Of Technology
September 07, 2017 - N°20170252417

Protein antigens are provided. The protein antigens typically include a peptide antigen conjugated or fused to a chaperone protein to form a “chaperone-antigen” that increases lymph node uptake; improves an immune response; or a combination thereof relative to the peptide antigen alone. The immune response can be, for example, increased antigen-specific proliferation, enhanced cytokine production, stimulation ...
Composition for preventing, improving or treating postmenopausal osteoporosis comprising scopolin
Ajou University Industry-academic Cooperation Foundation
September 07, 2017 - N°20170252363

Provided is a pharmaceutical composition for preventing, improving, or treating postmenopausal osteoporosis in women, the composition including, as an active ingredient, scopolin, a derivative thereof, or a pharmaceutically acceptable salt thereof, wherein scopolin has good efficacy in stimulating osteoblast differentiation, and is also effective in inhibiting a reduction in bone density after menopause, low density in a bone microstructure, a ...
Systems level state characteristics in experimental treatment of disease
Ajou University Industry-academic Cooperation Foundation
September 07, 2017 - N°20170251943

Methods and system for assessment of a state of the central nervous system (cns) of a subject and/or differentiation between states of the cns at a specific time point based on electrophysiological recordings of signals from at least two anatomical structures, wherein the signals are recorded from recording sites located in the anatomical structures, wherein the electrophysiological recordings comprise ...
Differentiation Patent Pack
Download 383+ patent application PDFs
Differentiation Patent Applications
Download 383+ Differentiation-related PDFs
For professional research & prior art discovery
inventor
  • 383+ full patent PDF documents of Differentiation-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Peptide having osteogenic differentiation promotion and periodontal ligament fibroblast activation promotion, and use of same
Caregen Co., Ltd
August 31, 2017 - N°20170247411

A peptide comprising an amino acid sequence of seq id no: 1 or seq id no: 2, according to the present invention, shows proliferation and differentiation promotion of osteoblast and proliferation and activation promotion of periodontal ligament fibroblast. A peptide, according to the present invention, increases bmp signaling such as smad1/5/8 phosphorylation and increases the growth of osteoblast and the expression of ...
Hydrogel compositions for use in cell expansion and differentiation
Wisconsin Alumni Research Foundation
August 31, 2017 - N°20170246357

Hydrogel compositions and methods of using hydrogel compositions are disclosed. Advantageously, the hydrogel compositions offer the ability to promote cellular expansion and/or cellular differentiation of various cells.
Methods for the selective treatment of tumors by calcium-mediated induction of apoptosis
Wisconsin Alumni Research Foundation
August 31, 2017 - N°20170246241

Tumor cells exhibit consistent abnormalities in calcium regulation. The present disclosure teaches methods by which such differences are exploited to induce apoptosis selectively in tumor/cancer cells while sparing normal cells. These methods are based upon employing drugs that, acting in synergistic combinations, trigger selective killing of malignant cells. Since the invention is based upon fundamental cell cycle requirements, to ...
Ex-vivo induced regulatory mesenchymal stem cells or myeloid-derived suppressor cells as immune modulators
Hadasit Medical Research Services & Development Ltd
August 31, 2017 - N°20170246210

A composition comprising tgfβ, an inflammatory agent and a tryptophan indoleamine-2,3 dioxygenase (ido) metabolite, in particular, tgfβ, ifnγ and kynurenine, is provided, as well as regulatory mesenchymal stem cell lines or myeloid-derived suppressor cell lines obtained by contacting mesenchymal stem cell lines or myeloid-derived suppressor cell lines, respectively, with the composition. Methods for inhibiting ...
B- and y -diketones and y -hydroxyketones as wnt/ b -catenin signaling pathway activators
Hadasit Medical Research Services & Development Ltd
August 31, 2017 - N°20170246154

Which activates wnt/β-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising parkinson's disease, strokes, ischemic cerebral disease, epilepsy, ...
Container for imaging
Perimeter Medical Imaging, Inc.
August 24, 2017 - N°20170241897

Various embodiments of systems and methods are described herein for obtaining wide field oct images and other types of image data from at least one portion of a sample. Various embodiments of systems and methods are described herein for assessing a degree of differentiation for a second region of an oct image of a tissue sample with respect to another ...
Snp marker as well as use and detection method thereof
Institute Of Apicultural Research, Chinese Academy Of Agricultural Sciences
August 24, 2017 - N°20170240978

The present invention relates to the field of biotechnology, and in particular to snp markers as well as use and detection method thereof. The present invention employs whole genome sequencing to conduct whole genome sequencing on a large number of individuals of apis mellifera sinisxinyuan, and obtains 21 pieces of snp information specific in apis mellifera sinisxinyuan, which become marker snp ...
Methods and systems for converting precursor cells into gastric tissues through directed differentiation
Children's Hospital Medical Center
August 24, 2017 - N°20170240866

Disclosed are methods of inducing formation of a gastric cells and/or a gastric tissue, such as in the form of a gastric organoid. The formation of gastric cells and/or tissue may be carried out by the activating and/or inhibiting of one or more signaling pathways within a precursor cell. Also disclosed are methods for using the disclosed ...
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