This page is updated frequently with new Differentiation-related patent applications.
|| List of recent Differentiation-related patents
|Method and controlling a reciprocating-piston engine having several cylinders|
A method for controlling a reciprocating-piston engine encompassing several cylinders, including generating a discrete-time signal by measuring a state variable of the reciprocating-piston sensor by way of a sensor and an associated evaluation circuit, superimposing onto the signal a summand signal obtained by time differentiation of the signal, or filtering the signal, in such a way that an amplitude of the signal is selectively made larger or smaller at useful frequencies of the signal, and further processing the superimposed signal by way of a user function related to at least one cylinder. A corresponding apparatus, a corresponding computer program, and a corresponding storage medium are also provided..
Robert Bosch Gmbh
|Th17 differentiation markers for acne and uses thereof|
A method is described for using ror gamma t or ror alpha to diagnose acne and/or to screen inhibitors of th17 differentiation. Specifically described, are methods of inhibiting ror gamma t or ror alpha and use of the screened inhibitors in acne treatment..
Galderma Research & Development
|Pri-mirna libraries and methods for making and using pri-mirna libraries|
Provided are methods for the design, preparation, and use of non-native pri-micrornas (pri-mirnas), pri-microrna (pri-mirna) scaffolds, and libraries of non-native pri-mirnas employing pri-mirna scaffolds. Also provided are methods for identifying non-native pri-mirnas, combinations of two or more non-native pri-mirnas, and mirnas derived from the processing of such non-native pri-mirnas, which mirnas exhibit one or more desired functional activities.
|Differentiation of human pluripotent stem cells to multipotent neural crest cells|
The present invention relates to the differentiation of human pluripotent cells, including human pluripotent stems cells to produce a self-renewing multipotent neural crest cell population in a single step method without the requirement of isolation of intermediate cells and without appreciable contamination (in certain preferred instances, virtually none) with pax6+ neural progenitor cells in the population of p75+hnk1+ap2+ multipotent neural crest-like cells. The multipotent neural crest cell population obtained can be clonally amplified and maintained for >25 passages (>100 days) while retaining the capacity to differentiate into peripheral neurons, smooth muscle cells and mesenchymal precursor cells..
University Of Georgia Research Foundation, Inc.
|Directed differentiation of astrocytes from human pluripotent stem cells for use in drug screening and the treatment of amyotrophic laterial sclerosis (als)|
The present invention discloses a method of identifying agents that affect human astrocytes functionality using ex-vivo differentiated pluripotent stem cells (psc). In addition, the use of human progenitor astrocytes or human astrocytes for the treatment of amyotrophic lateral sclerosis (als) in a human subject is also disclosed..
|Method of producing retinal pigment epithelial cell|
Provided are a production method of retinal pigment epithelial (rpe) cells that improves differentiation induction efficiency of pluripotent stem cells into rpe cells, and can provide highly pure rpe cells by a simple and easy operation in a short period, a culture method of rpe cells that can stably grow and culture a cell, a toxicity/efficacy evaluation method using rpe cells useful for transplantation therapy, and a therapeutic drug for a retinal disease. The invention relates to a production method of rpe cells, comprising adhesion culture of human pluripotent stem cells using a culture substrate coated with a laminin-e8 fragment, a culture method of rpe cells, comprising adhesion culture of rpe cells using a culture substrate coated with a laminin-e8 fragment, a toxicity or efficacy evaluation method using rpe cells obtained by producing or culturing by the method, and a therapeutic drug for a retinal disease, containing the rpe cells..
|Methods and compositions for ex vivo generation of developmentally competent eggs from germ line cells using autologous cell systems|
The present technology provides for methods for the directed differentiation of multi-potent cells, female germ line stem cells, or oogonial stem cells into oocytes, granulosa cells and/or granulosa precursor cells, i.e.,“synthetic granulosa cells.” the synthetic granulosa cells are useful in methods for growth and maturation of follicles or follicle-like structures and immature oocytes. Additionally, the synthetic granulosa cells are useful in methods of increasing ovarian derived hormones and growth factors in a subject in need thereof..
|In vitro production of foregut stem cells|
This invention relates to the differentiation of pluripotent cells (pscs) into foregut stem cells (fscs) using a definitive endoderm induction medium comprising a tgffi ligand, fibroblast growth factor (fgf), bone morphogenetic protein (bmp) and a pi3k inhibitor to differentiate the pluripotent cells into definitive endoderm cells and a foregut induction medium comprising a tgfβ ligand to differentiate the definitive endoderm cells into foregut stem cells (fscs). Methods of differentiation, populations of foregut stem cells, culture media and kits are provided..
Cambridge Enterprise Limited
|Kdm1a inhibitors for the treatment of disease|
Disclosed herein are new compounds and compositions and their application as pharmaceuticals for the treatment of diseases. Methods of inhibition of kdm1a, methods of increasing gamma globin gene expression, and methods to induce differentiation of cancer cells in a human or animal subject are also provided for the treatment of diseases such as acute myelogenous leukemia..
Imago Biosciences, Inc.
|Therapy for promoting cell growth|
There is disclosed the use of a composition for promoting neuronal growth of neurons in tissues of the central or peripheral nervous system. There is also disclosed a method for inducing proliferation or differentiation of neuronal cells..
Moleac Pte. Ltd.
Method of enhancing hematopoietic cell transplantation
The invention relates to a method for enhancing the transplantation of hematopoietic cells to supplement or fully reconstitute the hematopoietic system, such as in myeloablated patients or patients otherwise deficient in hematopoietic cells. The method involves administering cd34+ cells having enhanced expression of one or more of aml-1, mysm1, hif1a, profilin-1, phospho-gsk-3beta, skp2, cbx7, bmi-1, tcf1, musashi-2, or fli1 at levels that provide desirable therapeutically effective amounts of self-renewal of the administered cells and desirable therapeutically effective amounts of differentiation of the administered cells into the various progeny cells of the hematopoietic system (i.e., therapeutically effective amounts of hematopoietic reconstitution).
Torque limiting system
The present invention relates to torque transfer and torque limiting system technology and applications. This invention relates to providing improved torque limiting systems that employ tolerance rings for controlling transmitting power between a single power-input shaft and one or more power-output shafts, which can protect mechanical equipment and drivetrains from damage by mechanical overload.
Bair-ling Technologies, Llc
Markers for differentiation of stem cells into differentiated cell populations
Provided herein are systems and methods for identifying cell-specific differentiation markers. In particular, provided herein are systems and methods for generating induced pluripotent cells (ips) from human cells, differentiating the ips into differentiated cells, and identifying differentiation specific markers..
Regenerative Medical Solutions, Inc.
Chemically defined culture medium for stem cell maintenance and differentiation
The present invention is directed to a low protein medium for the culture of pluripotent stem cells comprising one or more polysaccharides. The medium of the present invention can support cell culture objectives, for example cell survival, maintenance, passaging, proliferation, pluripotency, cloning, differentiation and induced pluripotent stem (ips) cell derivation..
The U.s.a., As Represented By The Secretary, Department Of Health & Human Services
Treatment of diseases caused by abnormal lymphocyte function with an hdac6 inhibitor
An hdac6 inhibitor (a compound of formula i) is shown to reduce the pathogenesis associated with the b cell mediated autoimmune disease, systemic lupus erythematosus (sle) administration of a compound of formula i attenuated many of the symptoms characteristic of sle including splenomegaly, abnormal b cell differentiation, an increase in the number double-negative thymic t cells, an increase in the level of auto-antibodies such as anti-dsdna, immune complex-mediated glomerulonephritis and an increase in inflammatory cytokine production. Treatment with a compound of formula i also increased the number of the subject's splenic treg cells while removing circulating auto-antibodies inhibition of hdac6 altered bone marrow b cell differentiation by increasing the percentage of cells in the early-stage developmental fractions of both pro- and pre-b cells.
Virginia Tech Intellectual Properties, Inc.
An anti-leukemic agent useful for inducing differentiation in myeloid leukemia cells
The present invention provides the compound ormeloxifene [3,4-trans-2,2-dimethyl-3-phenyl-4-p-(beta-pyrrolidinoethoxy)phenyl-7-methoxy chroman] as useful in inducing differentiation in wide range of myeloid leukemias including acute promyelocytic leukemia, acute myeloid leukemia and chronic myeloid leukemia where block in differentiation is common feature. Ormeloxifene induced differentiation that is marked by increase in differentiation marker proteins like c/ebpα and surface proteins such as cd11b and granulocyte colony stimulating factor receptor (gcsfr).
Council Of Scienticfic & Industrial Research
Mobile network operator (mno) control of wifi qos via eap/diameter
A mobile network operator (mno) may control wifi qos. 3gpp has specified control mechanisms for various levels of quality of service (qos) over the cellular access and core network.
Convida Wireless, Llc
Method for culturing mesenchymal stem cells according to cell size
A method for culturing mesenchymal stem cells. The method includes isolating mesenchymal stem cells having a size of 8 μm or less and culturing the mesenchymal stem cells in a medium containing calcium and magnesium and under a low oxygen condition.
Medipost Co., Ltd.
Use of cardiotrophin to modulate stem cell proliferation
Methods of promoting stem cell proliferation by contacting the cells with cardiotrophin-1 (ct-1) are provided. The methods may further include contacting the stem cells with one or more stem cell modulators that promote differentiation of the stem cells.
Ottawa Hospital Research Institute
Method for enucleating nucleated erythrocyte, and enucleation inducer
Provided is a factor capable of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time. More particularly, provided are a method of inducing enucleation, which is a final stage of erythrocyte differentiation, within a short time by adding a compound derived from proopiomelanocortin (pomc) to an undifferentiated (nucleated) erythrocyte, and an enucleation inducer including the compound..
Kanazawa Medical University
Differentiation of rpe progenitors into neuron-like cells
A method of permanently culturing rpe cells under hypoxia, and differentiating the rpe cells into neuronal like cells.. .
Stemedica Cell Technologies, Inc.
Human ipsc-derived vascular-related and hematopoetic cells for therapies and toxicology/drug screenings
Described herein are cells, cell culture methods, and cell culture media compositions useful for producing and maintaining ipsc-derived cell lines that are of higher purity and maintain cell type integrity better than current ipsc-derived cell lines. Also disclosed are methods of using the described cells and media, such as therapeutic methods of use for the described cells.
The Usa, As Represented By The Secretary, Department Of Health And Human Services
Method for inducing differentiation of induced pluripotent stem cells and selecting the same
It is an object of the present invention to provide a method for highly efficiently inducing differentiation of ips cells into cells having functions of interest, and a method for selecting ips cells having high differentiation induction efficiency for differentiation of the ips cells into cells of interest from among the produced ips cells. The present invention relates to a method for inducing differentiation of induced pluripotent stem cells, which comprises culturing induced pluripotent stem cells on a structure comprising cells and/or a component derived from the cells, wherein the cells in the structure and the differentiation-induced cells are the same type of cell..
Medical devices containing rapamycin analogs
A medical device comprises a supporting structure capable of containing or supporting a pharmaceutically acceptable carrier or excipient, which carrier or excipient may contain one or more therapeutic agents or substances, with the carrier preferably including a coating on the surface thereof, and the coating containing the therapeutic substances, such as, for example, drugs. Supporting structures for the medical devices that are suitable for use in this invention include, but are not limited to, coronary stents, peripheral stents, catheters, arterio-venous grafts, by-pass grafts, and drug delivery balloons used in the vasculature.
Methods and compositions for treating bone diseases
The invention provides methods and compositions for stimulating or promoting bone generation and regeneration, for stimulating or increasing differentiation, activation or function of osteoblasts, for inhibiting or decreasing differentiation, activation or function of osteoclasts, and for treating bone diseases such as osteonecrosis by administering to a subject a therapeutically effective amount of a pro-nerve growth factor (prongf) or a pro-brain derived neurotrophic factor (probdnf) or an analog, homolog, fragment or derivative thereof. The pro-nerve growth factor (prongf) or a pro-brain derived neurotrophic factor (probdnf) or an analog, homolog, fragment or derivative thereof may be a mutated or poorly hydrolyzed form of prongf or probdnf..
Methods of transdifferentiation and methods of use thereof
Disclosed herein is a method for manufacturing a population of human insulin producing cells from non-pancreatic β-cells, wherein the resulting insulin producing cells have increased insulin content, or increased glucose regulated secretion of insulin, or a combination of both.. .
Tel Hashomer-medical Research, Infrastructure And Services Ltd.
Composition for treating or preventing bone diseases, comprising halofuginone as active ingredient
The present invention relates to a composition for treating or preventing bone diseases comprising halofuginone as an active ingredient and, more specifically, to a composition for treating or preventing bone diseases, comprising, as an active ingredient, halofuginone having an osteoclast differentiation inhibitory efficacy and an osteoblast differentiation stimulatory activity. The composition for treating or preventing bone diseases, comprising halofuginone as an active ingredient, according to the present invention, reduces the expression of th17 cells and increases the expression of treg cells, thereby representing an effect of inhibiting osteoclast differentiation and being capable of also effectively inhibiting bone resorption by osteoclasts.
The Catholic University Of Korea Industry-academic Cooperation Foundation
Sdn based interdomain and intradomain traffic engineering
A method is implemented by a centralized control plane device for a software defined networking (sdn) network. The method performs joint inter-domain and intra-domain traffic engineering as a single optimization process with location varying objectives.
Telefonaktiebolaget L M Ericsson (publ)
Communication system and phase error estimating method thereof
A communication system includes a receiving circuit and a phase error estimating circuit. The receiving circuit receives an input signal x, which has an input phase θ in a polar coordinate system.
Mstar Semiconductor, Inc.
Beat tone full waveform inversion
A full wave inversion (fwi) may utilize an amplitude-frequency-differentiation (afd) or a phase-frequency-differentiation (pfd) operation to form a velocity model of a subterranean formation utilizing recovered low wavenumber data. Received seismic data is processes to isolate two data signals at different frequencies.
Advanced Geophysical Technology Inc.
Open-loop natural thermal energy releasing system with partial reflux
An open-loop type heat equalization device utilizing the heat exchange fluid as the carrier to transmit the thermal energy of a natural thermal energy storage body to the temperature differentiation body at the exterior, and wherein the fluid inlet/outlet port (4011) of the pipeline structure (401) and a fluid inlet/outlet port (3012) of a pipeline structure (301) is often structured as an open state, and the space limiting and flow direction guiding structure of the heat exchange fluid (104) is nod provided, the main features of the present invention includes one or more than one of the 1) to 7) structural devices including: 1) installing the space limiting and flow direction guiding structure (201) of the heat exchange fluid (104) between the fluid inlet/outlet port (4011) of the pipeline structure (401) and a fluid inlet/outlet port (3012) of a pipeline structure (301) for allowing the heat exchange fluid (104) with thermal energy to be released from the fluid inlet/outlet port (4011) of the pipeline structure (401), and a part thereof is returned to the fluid inlet/outlet port (3012) of the pipeline structure (301) for flowing back to the heat gaining device (101); 2) installing an outward-expanding arc-shaped fluid chamber (108) at one or more than one of turning locations of the open-loop flowpath configured by the heat gaining device (101), the pipeline structure (301), the space limiting and flow direction guiding structure (201) and the pipeline structure (401) for temporally storing a part of the heat exchange fluid (104) and moderating the flow speed of the heat exchange fluid (104) with thermal energy for reducing the flow damping of the flowpath to the heat exchange fluid (104); 3) installing an auxiliary heating/cooling device (115); 4) installing an auxiliary fluid pump (107); 5) installing a heat exchange fluid temperature sensing device (ts201); 6) installing an environment temperature sensing device (ts202); and 7): installing an electric power control unit (ecu200).. .
Overlock sewing machine
In an overlock sewing machine, a main shaft fixing operating shaft is provided with a differentiation ring that can be swung in a predetermined range such that, when the rotation of a main shaft is to be enabled, it is set to an enable state in a stationary state, and when the rotation of the main shaft is disabled, it is swung and shifted from the enable position. Furthermore, a looper cover open/closed detection configuration is configured by modifying a part of a typical known configuration.
Janome Sewing Machine Co., Ltd.
Method for inducing pluripotent stem cells and pluripotent stem cells prepared by said method
The present disclosure relates to a method for inducing pluripotent stem cells by inducing reprogramming and/or dedifferentiation of differentiated adult cells using shikimic acid, a plant extract or plant stem cells containing shikimic acid and an extract of dedifferentiated stem cells (callus), pluripotent stem cells prepared by the method and a composition containing the pluripotent stem cells. In accordance with the present disclosure, ethical concerns implicated with the use of eggs to prepare pluripotent stem cells such as embryonic stem cell can be resolved.
Seoul National University R&db Foundation
A method to direct differentiation of pluripotent stem cells into functional heart muscle
The present invention is directed to a method for producing bioengineered heart muscle (bhm) from pluripotent stem cells, generally comprising the steps of inducing mesoderm differentiation, cardiac differentiation, and cardiac maturation by directed tissue formation. The method is a robust, serum-free and reproducible way to produce bhm for multiple applications, and is applicable to multiple pluripotent stem cell lines.
Georg-august-universitÄt GtÖtingen Stiftung Öff Entlichen Rechts, UniversitÄtsmedizin
Pluripotent stem cell expansion and passage using a stirred tank bioreactor
Provided herein are novel methods for expansion and passaging of cell aggregates comprising stem cells and/or differentiated cells and comprising the use of closed systems in stirred tank bioreactors. The methods of the invention permit closed system serial passage expansion of pluripotent stem cells and/or progeny thereof with associated pluripotency markers and differentiation potential..
General Electric Company
Signature of tl1a (tnfsf15) signaling pathway
The present invention relates to the finding that tl1a enhances differentiation of th17 cells, and enhance il17 secretion from th17 cells. In one embodiment, the present invention provides a method of treating an inflammatory disease comprising determining the presence of a tl1a signaling profile, and treating the disease by administering a composition comprising a therapeutically effective dosage of one or more inhibitors of tl1a or th17 cell differentiation.
Cedars-sinai Medical Center
Methods for modulating immune responses during chronic immune conditions by targeting metallothioneins
Described herein are novel compositions comprising mt1 and/or mt2 modulators (i.e., inhibitors or activators), and methods using these agents for targeting different t-cell populations, for example, type 1 regulatory (tr1) cd4+ cells and exhausted cd8+ t-cells cells. Aspects of the invention relate to inhibitors of mt1 and/or mt2 to increase the differentiation of cd4+ cell trl1 cd4+ cells and increase in the activity of tr1 cells, e.g., to increase il-10 production.
The Brigham And Women's Hospital, Inc.
Guidewire clamp and introducer
A guidewire for medical procedures can be maintained in a coiled configuration with a clamp. Multiple clamped and coiled guidewires may be stored in a fluid-filled, storage bowl concurrently.
Mesenchymal stem cell differentiation
The present invention provides for methods and compositions for treating or preventing arthritis and joint injury.. .
Multiple oil-emission measuring device for engines
A multiple oil-emission device for hydrocarbon emissions in an exhaust-gas mixture, comprising an exhaust-gas probe, which has a transfer capillary, and a measurement channel, which has an ion source and a filter apparatus having a measuring apparatus. The transfer capillary has a drop-catching apparatus at the tip of the transfer capillary, which drop-catching apparatus comprises a short throttle segment and a transfer segment, which adjoins the throttle segment in a flow direction and is at least ten times longer.
Power restriction management system
A power restriction management system includes a network switching device with a preinstalled power restriction sequence value and a managing server. The network switching device is connected to a power source to acquire power and at least one electronic device to perform power restriction in the electronic device.
Luxul Technology Incorporation
Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof
The present invention relates to an inhibitor of neurocalcin delta (ncald) for use in a method for the treatment or prevention of a patient suffering from a disorder associated with a pathological calcium homeostasis. Furthermore, the present invention refers to the use of such inhibitor of ncald for inducing axon proliferation in vitro and to a method for the differentiation and/or maturation of neuronal stem cells (nscs) in vitro and to the use of such inhibitor of ncald to restore impaired endocytosis being a consequence of disturbed ca2+ homeostasis in synaptic terminals essential for development, maturation and maintenance of synapses and neuromuscular junctions (nmjs)..
UniversitÄt Zu KÖln
Method for enhancing therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases
A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises pre-treating the stem cells with ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the treatment is conducted in a culture medium of the stem cell..
Gwo Xi Stem Cell Applied Technology Co., Ltd.
Generation of endocrine progenitor cells from human pluripotent stem cells using small molecules
The present invention relates to differentiation of stem cells into a homogeneous endocrine progenitor cell population suitable for further differentiation into pancreatic beta-cells. The present invention provides methods for obtaining ngn3/nkx2.2 double positive endocrine progenitor cells by exposing precursor cells to a tgf-β type i receptor inhibitor, a bmp antagonist, an adenylate cyclase activator and nicotinamide and/or exposing to the precursor cells to a selection of small molecules..
Takara Bio Europe Ab
Malignant and non-malignant disease treatment with ras antagonists
The present disclosure describes new inhibitors or antagonists of ras useful for the treatment of conditions resulting from ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition.
Pisces Therapeutics, Llc
Method and system for producing gluten-free oats
A method and system for removing foreign grains from oat grains to establish gluten-free oats, i.e., oat grains having gluten levels below 20 ppm and, more preferably, below 10 ppm, relies upon performing various mechanical differentiation operations on a combination of grains, including oats and foreign, or gluten containing, grains. The mechanical differentiation operations can be arranged in series or in a combination of series and parallel operations.
General Mills, Inc.
Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof
This invention provides a matrix scaffold for three-dimensional (3d) cell cultivation, a method of its construction, and its uses. The matrix scaffold results from a crosslinking reaction of a fibroin-like substance prepared by a specific method from silk cocoons or filaments, chitosan and crosslinking agents.
Suzhou Cancercell Biotechnology Co. Ltd
Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use
This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
Advanced Neuroregenerative Therapies, Llc
Nanofibrous photoclickable hydrogel microarrays
Nanofibrous hydrogel microarray systems that act as facile, high throughput platforms for in vitro drug discovery and investigation and screening of combinatorial effects of physical and biochemical cues on maturation and differentiation of mammalian cells.. .
The Regents Of The University Of Colorado, A Body Corporate
Method of assessing hair colour changes
The invention provides a method of assessing the potential colour protecting effect in vivo of a test formulation such as rinse-off hair treatment formulation, the method comprising the steps of: providing a sample of the test formulation to be assessed; providing a model substrate in the form of a hair switch which has been artificially coloured; applying the test formulation to the hair switch; subsequently rinsing the test formulation from the hair switch; collecting the rinse liquor and analysing it for the presence of eluted colour; characterised in that the artificial colour used to colour the hair switch is a permanent hair colorant with a shade level 1 or 2 according to the international colour chart (i.c.c.). The method provides improved sensitivity and differentiation, and enables the tester to compare different technologies in terms of effectiveness..
Conopco, Inc., D/b/a Unilever
Methods, systems, and compositions relating to mirna-146a
Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microrna-146a, a promoter of microrna-146a expression, a microrna-146a mimic, thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, disease, or injury in mammals, including in human beings..
Henry Ford Health System
Methods for accelerated and enhanced cardiac differentiation of ips cells by electrical stimulation
Methods of generating cardiomyocytes from induced pluripotent stem cells (ipscs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from ipscs using electrical stimulation.
University Of Cincinnati
Method of nociceptor differentiation of human embryonic stem cells and uses thereof
The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hesc), human induced pluripotent stem cells (hipsc), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hesc and/or hipsc to nociceptors (i.e.
Memorial Sloan Kettering Cancer Center
Collagen scaffold modified by covalent grafting of adhesion molecules, associated methods and use thereof for cardiovascular and thoracic cell therapy and contractile tissue engineering
Three-dimensional solid contractile collagen scaffolds having improved biological properties and electromechanical performance are provided. The scaffolds can be used for cell transplantation, including the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously.
Bioresorbable wound dressing
The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues.
Carl Freudenberg Kg
Inhibition of thymine dna glycosylase in the treatment of cancer
The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine dna glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine dna glycosylase in cancer cells.
Institut De Génétique Et De Biologie Moléculaire Et Cellulaire
Systems and methods for monitoring health in a shared living environment
The systems and method for monitoring health in a shared living environment may provide a collection of components and/or accessories that may, in various aspects, assist in deterring sexual coercion, sexual assault, and rape, provide a rapid response pathway in the event of sexual coercion or assault, stimulate and support event reporting by complainants, reduce false positive and false negative rates (for both accused and accusers), and/or enable later differentiation between meritorious and meretricious complainants and counter complainants (defendants/respondents) in future disciplinary or legal proceedings. In addition, other aspects of the systems and method described herein may assist in monitoring promoting other healthy lifestyle choices, such as sleep and study choices..
Cell culture medium for the growth and differentiation of cells of the hematopoietic lineage
A method for the production of cells of the hematopoietic lineage includes culturing hematopoietic stem cells (hsc) or embryonic bodies with a cell culture medium (the cell culture medium includes insulin at a concentration of from 1 to 50 μg/ml, transferrin at a concentration of from 100 μg/ml to 2000 μg/ml and plasma or serum at a concentration of from 1% to 30%) under conditions allowing producing cells of the hematopoietic lineage; and collecting cells of the hematopoietic lineage.. .
Assistance Publique - Hopitaux De Paris
Methods for inducing the differentiation of blood monocytes into functional dendritic cells
Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins.
Container and lid
A container lid (10) is provided herein having structurally reinforcing ribs (50) therein. The ribs (50) increase the strength of the lid across a central region thereof.
Kraft Foods Group Brands Llc
Apparatus for automated differential hair transplant
The present invention is useful to reduce the time and cost associated with the intervention, improve the quality of the operation and the final result, in terms of capillary density, contemplating the study of cell differentiation of follicles with the required estimate of time required regarding the growth. Minimizes the positional discomfort of the patient, the pain associated with the administration of anaesthesia, among other inconveniences usually experienced by the patient in this type of intervention.
System and facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer
R-r interval data is presented in a format that includes relevant near field and far field ecg data. The near field view provides a “pinpoint” classical view at classical recording speed.
Bardy Diagnostics, Inc.
Method for creating endometriotic cells and endometriosis model animal
Provided is a method of producing a cell having properties of endometriosis (hereinafter referred to as “endometriotic-like cell”) from a human mesenchymal stem cell. Also provided are a method of producing an animal model exhibiting human endometriosis, the method including transplanting the cell to an animal, and an animal model of endometriosis.
Astellas Pharma Inc.
Variable metal multi-gate metal oxide semiconductor capacitor radiation sensor for improved gain and tissue equivalence
A method and apparatus is disclosed for differentially altering the radiation response across multiple moscap sensors by placing different thin gate materials with different atomic numbers on a series of mos-based radiation sensors. The secondary electrons created in high-atomic weight materials (such as gold) at lower incident photon energy levels enable a tissue equivalent radiation response and radiations source identification/differentiation.
Assay for screening compounds that selectively decrease the number of cancer stem cells
The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (cscs). This method includes (a) contacting a csc from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the csc or increases differentiation of the csc relative to a csc that has not been contacted with the candidate agent.
Epithelial cell differentiation of human mesenchymal stromal cells
The present invention relates to the discovery that different stem cell types (e.g., bone marrow-derived mesenchymal stem cells (bm-msc) and adipose-derived mesenchymal stem cells (at-msc)) undergo large changes in lung epithelial marker expression depending on the substrate on which they are cultured. The present invention includes methods and compositions for differentiating of mesenchymal stem cells, such as bone marrow and adipose tissue mesenchymal stem cells, into lung cells, populations of lung cells, and methods of alleviating or treating a lung defect in a subject in need thereof..
Small molecule cellular reprogramming to generate cardiomyocytes
Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become cardiac progenitor cells or cardiomyocytes.. .
Compositions and methods for treating bone conditions
A method of treating a degenerative bone condition of a subject includes administering to hematopoietic progenitor cells or osteoclast progenitor cells of the subject at least one agent that substantially reduces the interaction of at least one of c3a or c5a with the c3a receptor (c3ar) and/or c5a receptor (c5ar), a stat3/il-6 signaling pathway antagonist, and a combination thereof, the agent being administered to the hematopoietic progenitor cells or osteoclast progenitor cells at an amount effective to inhibit osteoclast differentiation of hematopoietic progenitor cells or osteoclast progenitor cells.. .
C-met modulators and use
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-met, kdf, c-kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.
Slide opening display and mail package
An economical package comprising an inner sliding piece assembled inside of one or more outer sleeves, where the inner sliding piece may contain a gift card, loyalty card, product, or promotional messages, and the card, product or messages can be revealed by pulling the inner sliding piece at least partially out of the outer sleeve. The package assembly can provide differentiation, protection, consumer information, and an ability to reuse the package for presentation of the card or information..
Management of osteoarthritis using pooled allogeneic mesenchymal stem cells
The present disclosure relates to a composition and method for management of osteoarthritis, including improvement in pain and cartilage regeneration of knee joint affected by osteoarthritis. The present disclosure also relates to a kit for treating osteoarthritis and the method of assembling the same.
Test strips for visual differentiation of liquid mixture composition
A test strip device exhibits visual changes, such as color changes, when there is a only slight difference in the composition of liquids such as gasoline, oil, ethanol and water. Such a slight liquid composition difference usually requires a sophisticated and expensive instrument to differentiate.
Selective enrichment medium for carbapenem-resistant bacteria
The present invention relates to a method for direct detection and differentiation of carbapenem-resistant bacteria in a sample comprising (i) inoculation with said sample of a culture medium comprising at least meropenem and/or ertapenem and at least one chromogenic agent, (ii) incubation of said culture medium under conditions allowing the growth of carbapenem-resistant bacteria, and (iii) detection of colonies formed on said culture medium corresponding to a carbapenem-resistant bacteria, as well as a culture medium suitable for use in such a method.. .
Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
Disclosed herein are methods for generating sc-β cells using chemically defined, completely serum free media, and isolated populations of sc-β cells for use in various applications, such as cell therapy.. .
Peptide for suppressing osteoclast differentiation and use thereof
The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (il)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of nf-κb and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-b ligand (rankl)-rank signaling pathway, and suppresses the expression of a rankl or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (trap), cathepsin k, or tnf receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration.
Peptides and their use in the treatment of skin
Embodiments of the invention are related generally to the methods of diminishing the signs of aging in and/or improving health of human integuments, such as skin, and compositions comprising peptides useful therefor. The compositions according to the invention may comprise one or more peptides or fragments or derivatives thereof derived from a growth factor, e.g., growth differentiation factor 11 (gdf11), in a topically acceptable vehicle..
Modified jvm with multi-tenant application domains and class differentiation
A method and system for operating a modified java virtual machine (jvm) which is able to simultaneously host multiple java application programs is disclosed. In a first modification the jvm is modified to permit multiple class definitions of some of the java application programming interface (api) classes, so called non-sensitive classes, to be loaded multiple times but restrict other java api classes, so called sensitive classes, to be loaded only once, preferably onto a bootstrap class loader.
Marker for statin treatment stratification in heart failure
The present invention is directed to a method of identifying a patient having heart failure as likely to respond to a therapy comprising a statin. The method is based on measuring the level of at least one marker selected from gdf-15 (growth differentiation factor 15), urea, shbg (sex hormone-binding globulin), uric acid, plgf (placental growth factor), il-6 (interleukin-6), transferrin, a cardiac troponin, sflt-1 (soluble fms-like tyrosine kinase-1), prealbumin, ferritin, osteopontin, sst2 (soluble st2), and hscrp (high sensitivity c-reactive protein) in a sample from a patient.
Roche Diagnostics Operations, Inc.
Generation of anterior foregut endoderm from pluripotent cells
The invention is directed to in vitro methods of inducing differentiation of anterior foregut endoderm and the enriched populations of anterior foregut endoderm produced by such methods. Such enriched populations are useful for studies of the molecular events that occur during differentiation and for generating cells for cell replacement therapy..
Mount Sinai School Of Medicine
Growth differentiation factor 15 (gdf-15) constructs
Constructs comprising gdf15, and mutants thereof are provided. In various embodiments the constructs comprising gdf15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder.
Methods and compositions for labeling polypeptides
Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms.
President And Fellows Of Harvard College
Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent.
Material for treatment of cerebral infarction
A material for treatment of cerebral infarction ameliorates angiopathy at a cerebral infarction region and improves brain function. The material for treatment of cerebral infarction according to the present invention comprises a dental pulp stem cell including at least one of a cd105-positive cell, an sp cell, a cd24-positive cell, a cd271-positive cell, and a cd150-positive cell.
National Center For Geriatrics And Gerontology
Methods and devices for intraoral tactile feedback
The present invention is directed to methods and devices for teaching the proper configuration of the oral articulators, particularly the tongue, corresponding to particular speech sounds by providing intraoral tactile feedback. Intraoral tactile feedback is achieved by placing nodes in the oral cavity of the patient in locations corresponding to the proper lingual position required to produce a target sound.
Articulate Technologies, Inc.
Stem cell differentiation determination device, method, and program
A stem cell differentiation determination device includes an observation image acquisition unit that captures an image of an observation region including a stem cell in time series to acquire at least two observation images, a feature amount acquisition unit that acquires at least one feature amount of the stem cell for each observation image, a determination unit that determines whether or not the stem cell has been differentiated, on the basis of the feature amount, a change information acquisition unit that acquires information about a change in the feature amount between the observation images captured in time series or information about a change in a determination result from undifferentiation to differentiation between the observation images, and an output unit that outputs the information about a change in the feature amount or the information about a change in the determination result.. .
Composition containing ppar-gamma neddylation inhibitor for inhibiting adipocyte differentiation and use thereof
Provided is a method for suppressing an adipose differentiation comprising administering to a subject in need thereof a ppar-v neddylation inhibitor for inhibiting adipocyte differentiation and a method for screening an adipocyte differentiation inhibitor using ppar-v neddylation associated with adipocyte differentiation. The inhibitor of a neddylation pathway of ppar-v inhibits the differentiation from mesenchymal stem cells to mast cells, and thus can be effectively used to treat obesity, and particularly, can be also useful in the treatment of severe obesity which cannot be excepted to be treated by existing obesity treatment agents..
Seoul National University R&db Foundation
Methods for reprogramming cells and uses thereof
Described herein are reprogrammed cells, and methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also descried are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming.
Differentiation of human pluripotent stem cells
The present invention provides a method for increasing the expression of mafa in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of mafa.. .
Janssen Biotech, Inc.
Method and medium for neural differentiation of pluripotent cells
The invention relates to a culture medium comprising an inhibitor of the bmp signaling pathway; and an inhibitor of the tgf/activin/nodal signaling pathway and to a method for obtaining a population of neural precursors using said culture medium.. .
Association Francaise Contre Les Myopathies
Method for treating gefitinib-resistant non-small-cell lung cancer
The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (nsclc) comprising administering an effective amount of a resveratrol analogue, (z)3,4,5,4′-tetramethoxystilbene (tms), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant nsclc cells comprising contacting the resveratrol analogue to the cells at an effective amount.
Macau University Of Science And Technology
Pharmaceutical composition for the treatment of diminution of bone tissue
A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from withaferin a (wfa), withanolide a, and withanone. The composition showed enhanced wfa bioavailability in rodents against plain wfa, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (bv/tv%) by 3 folds as compared to free withaferin a (wfa)..
Council Of Scientific & Industrial Research
Non-human animals having a humanized cluster of differentiation 47 gene
Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an endogenous cluster of differentiation (cd) gene, in particular a humanization of a cd47 gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous cd47 gene so that said non-human animals express a cd47 polypeptide that includes a human portion and a non-human portion (e.g., a murine portion)..
Regeneron Pharmaceuticals, Inc.
Non-human animals having a humanized cluster of differentiation 274 gene
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a cluster of differentiation 274 (cd274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous cd274 gene so that said non-human animals express a programmed cell death ligand 1 (pd-l1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion)..
Regeneron Pharmaceuticals, Inc.