 Patent Application Title |
Patent App Num. |
Date |
 Differentiation of power and channel count changes in optically amplified links | 20130148192 | 20130613 |
 Exemplary embodiments of the invention are drawn to a method and apparatus for the differentiation of power and channel count changes in optically amplified links. Additionally, configuration of a corresponding optical amplifier can be based on the determination of the power and channel count changes.
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| Method, device and system for scheduling data flow | 20130148605 | 20130613 |
 Embodiments of the present invention provide a method, device, and system for scheduling a data flow, which are used to improve the processing efficiency. A network side device marks a priority of a subsequent uplink and/or downlink data flow of a UE corresponding to a downlink data packet in the downlink data packet, and enables a downstream node to schedule an access network resource or air interface resource according to the priority. Therefore, a bearer does not need to be modified during the process of distinguishing different service flows and performing differentiation scheduling on different service flows, thereby reducing the workload and improving the processing efficiency.
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| Method, computer-readable medium, and apparatus for providing different services to different users of an aggregate endpoint in an internet protocol multimedia subsystem (ims) network | 20130148652 | 20130613 |
 Different services are provided to different users or groups of users of an aggregate endpoint in an internet protocol multimedia subsystem (IMS) network. The different users or groups of users are differentiated based on service profiles designated by different PUIDs for the different users or groups of users of each of the users or groups of users. Different services for transmission and/or receipt of packets for the different users or groups of users of the aggregate endpoint are provided, depending upon the differentiation between the different users or groups of users.
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| Preparative regimen for engraftment, growth and differentiation of non-hematopoeitic cells in vivo after transplantation | 20130149280 | 20130613 |
 The invention relates to methods of obtaining an expanded population of mammalian ex vivo cells and/or for treating a mammalian subject by (a) administering to a subject an effective amount of an agent that confers a growth disadvantage to at least a subset of endogenous cells at the site of engraftment; (b) administering to the subject an effective amount of a mitogenic stimulus for the ex vivo cells; and (c) administering the ex vivo cells to the subject, wherein the ex vivo cells engraft at the site and proliferate to a greater extent than the subset of endogenous cells, to repopulate at least a portion of the engraftment site with the ex vivo cells. The repopulated cells can be harvested for further use or be left... |
| Methods and compositions related to dopaminergic neuronal cells | 20130149717 | 20130613 |
 A method of differentiation stem cells cells by contacting stem cells with a dopaminergic differentiation agent is provided in certain aspects. For example, the agent may comprise substituted benzoxazole. These methods and compositions may be used in toxicological screens, e.g., to evaluate the neurotoxicity of a test compound or treatment of neurological disorders.
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| Novel micrornas for the detection and isolation of human embryonic stem cell-derived cardiac cell types | 20130150256 | 20130613 |
| The present invention relates to the use of human-derived microRNAs (miRNAs) as targets for the identification of cardiac and cardiac-like cell types. In particular, it relates to a specific set of miRNAs which have been found to be correlated to cardiac differentiation and can act to up or downregulate a number of putative mRNA targets to guide differentiation and also act as markers for a cardiac phenotype. In addition, it also relates to the use of these miRNAs as tools for the isolation, selection, purification and characterisation of cardiac and cardiac-like cells and tissues. The invention also encompasses the possible use of these miRNAs in the differentiation and maturation of cardiac or cardiac-like cell types.
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| Coded cap for use with a drug delivery device | 20130150802 | 20130613 |
| A cap-fit differentiation means for use with a medication or drug delivery device is described. The cap includes at least one first coding feature located on a surface of the cap, the at least one coding feature configured to interact with at least one second coding feature located on the drug delivery device. When the first and second coding features interact, feedback is provided to a user. The feedback may include tactile and/or audible feedback. The second coding feature may alternatively be located on the cartridge or cartridge holder.
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| Method of enhancing hematopoietic cell transplantation | 20130142761 | 20130606 |
| The invention relates to a method for enhancing the transplantation of hematopoietic cells to supplement or fully reconstitute the hematopoietic system. The method involves administering cells expressing CD34 and co-expressing HoxB4, wherein the HoxB4 is expressed at levels that provide therapeutically effective amounts of self-renewal of the administered cells. The method also involves administering cells expressing CD34 but not co-expressing HoxB4 or co-expressing HoxB4 in amounts so as to provide therapeutically effective amounts of differentiation of the administered cells into the various progeny cells of the hematopoietic system. To provide such cells to a subject, the invention relates to detecting such cells prior to treatment to ascertain whether such cells are present in clinically relevant amounts.
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| Antibody modulating the differentiation and function of dendritic cells via binding intercellular adhesion molecule-1 and use thereof | 20130142811 | 20130606 |
| The present invention relates to an antibody binding to human intercellular adhesion molecule-1 (ICAM-1) where the antibody is able to modulate the differentiation status of dendritic cells and prolong the graft survival. In addition, the present invention provides a pharmaceutical composition comprising the antibody, and method of using them for the treatment of disease.
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| Tolerogenic plasmacytoid dendritic cells co-expressing cd8-alpha and cd8-beta and methods of inducing the differentiation of regulatory t cells using same | 20130142830 | 20130606 |
| This invention discloses an unexpected discovery that plasmacytoid dendritic cells (pDCs) may be segregated into immunogenic or tolerogenic species based on novel biomarkers discovered herein. Exemplary biomarkers include CD8α+β+, CD8α+β−, CD8α−β−, C1q, and IL-9R. For example, pDCs with CD8α+β+, CD8α+β− are tolerogenic and CD8α−β− is immunogenic. Also disclosed are isolated pDCs, compositions comprising the pDCs, methods for isolating the pDCs, methods for treating immune-hyper-reactivity, such as airway hyper-reactivity, food allergy, asthma, and autoimmune disorders, by using compositions containing tolerogenic antigen presenting cells, preferably pDCs disclosed herein. Also disclosed are methods for identifying tolerogenic antigen presenting cells by using one or more novel biomarkers disclosed herein, including RALDH expression, CD8α, CD8βC1qa, C1qc, and IL-9R. Also disclosed are methods for inducing Treg cells by using the pDCs disclosed... |
| Method of inducing differentiation from pluripotent stem cells to germ cells | 20130143321 | 20130606 |
| This invention provides a method of producing an epiblast-like cell (EpiLC) from a pluripotent stem cell, which comprises culturing the pluripotent stem cell in the presence of activin A; a method of producing a primordial germ cell-like (PGC-like) cell a pluripotent stem cell, which comprises culturing the EpiLC obtained by the method above in the presence of BMP4 and LIF. Also provided are a cell population containing PGC-like cells as obtained by the method, and reagent kits for the EpiLC- and PGC-like cell-induction from a pluripotent stem cell.
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| Method for controlling proliferation of cord blood hematopoietic stem cells and use thereof | 20130143322 | 20130606 |
| The present invention provides a method for controlling the proliferation and differentiation of cord blood-derived hematopoietic stem cells with excellent safety when proliferating them by culturing. The hematopoietic stem cells are inoculated into a medium containing a sonicated liquid component of cord blood. The proliferation and differentiation of the cord blood hematopoietic stem cells can be inhibited in the presence of the sonicated liquid component of cord blood. On the contrary, the proliferation of cord blood hematopoietic stem cells can be accelerated by inoculating the hematopoietic stem cells into a medium containing a non-sonicated liquid component of cord blood. Thus, according to the present invention, by using serum derived from cord blood, it is possible to regulate the inhibition of the proliferation and differentiation of cord... |
| Chemical inducers of neurogenesis | 20130143885 | 20130606 |
| The present invention relates to compounds and methods for inducing neuronal differentiation in normal neural stem cells and brain cancer stem cells. The methods may take place in vitro, such as in isolates from the adult mammalian brain, or in vivo. Compounds and methods described herein may find use in the treatment of neurodegenerative and psychiatric diseases, the repair and regeneration of the nervous system, and in treatment of neurologic malignancy.
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| Stem cell differentiating agents and uses therefor | 20130143935 | 20130606 |
| The present invention relates to screens for compounds that can induce stem cell differentiation. In addition, isoxazoles and sulfonyl hydrazones are identified as general classes of compounds that can induce differentiation of stem cells into cells of neuronal and cardiac fate, respectively.
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| Methods and systems for converting precursor cells into intestinal tissues through directed differentiation | 20130137130 | 20130530 |
| The generation of complex organ tissues from human embryonic and pluripotent stem cells (PSCs) remains a major challenge for translational studies. It is shown that PSCs can be directed to differentiate into intestinal tissue in vitro by modulating the combinatorial activities of several signaling pathways in a step-wise fashion, effectively recapitulating in vivo fetal intestinal al development. The resulting intestinal “organoids” were three-dimensional structures consisting of a polarized, columnar epithelium surrounded by mesenchyme that included a smooth muscle-like layer. The epithelium was patterned into crypt-like SOX9-positive proliferative zones and villus-like structures with all of the major functional cell types of the intestine. The culture system is used to demonstrate that expression of NEUROG3, a pro-endocrine transcription factor mutated in enteric anendocrinosis is sufficient to promote differentiation... |
| Pharmaceutical or cosmetic composition containing nicotinic acid adenine dinucleotide phosphate or derivative thereof | 20130137177 | 20130530 |
| The present invention relates to a use of nicotinic acid adenine dinucleotide phosphate or a derivative thereof for promoting the differentiation of keratinocytes into fibroblasts. The present invention provides a pharmaceutical or cosmetic use of a composition containing NAADP or a derivative thereof for regenerating and improving a skin barrier, or preventing, improving or treating stratum corneum disorders such as psoriasis or atopy, and a use for promoting the differentiation of separated keratinocytes.
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| Means and methods for metabolic differentiation of non-alcoholic steatohepatitis from liver disease | 20130126722 | 20130523 |
| The present invention relates to the field of diagnostic methods. Specifically, the present invention contemplates a method for diagnosing a liver disease in a subject and a method of differentiating between NASH and NAFLD. The invention also relates to tools for carrying out the aforementioned methods, such as diagnostic devices.
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| Detection, identification and differentiation of eubacterial taxa using a hybridization assay | 20130130258 | 20130523 |
| The present invention relates to a method for the specific detection and/or identification of Enterococcus species, in particular Enterococcus faecalis and/or Enterococcus faecium, using new nucleic acid sequences derived from the ITS (Internal Transcribed Spacer) region. The present invention relates also to said new nucleic acid sequences derived from the ITS region, between the 16S and 23S ribosomal ribonucleic acid (rRNA) or rRNA genes, to be used for the specific detection and/or identification of Enterococcus species, in particular of Enterococcus faecalis and/or Enterococcus faecium, in a biological sample. It relates also to nucleic acid primers to be used for the amplification of said spacer region of Enterococcus species in a sample.
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| Induction of a mature hepatocyte phenotype | 20130130297 | 20130523 |
| The present invention relates to a method for producing cells having a mature hepatocyte phenotype, comprising (a) providing a cell population comprising precursor cells of mature hepatocytes, wherein said cell population is obtained from a subject or derived from a cell line; and (b) introducing into said precursor cells a group of differentiation factors and/or the nucleic acid sequences encoding said differentiation factors, said group consisting of (i) one or more member(s) of the Foxa subfamily, (ii) HNF-4α and (iii) C/EBPα, thereby differentiating said precursor cells into cells having a mature hepatocyte phenotype.
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| Method and device for combined detection of viral and bacterial infections | 20130130367 | 20130523 |
| A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections. In one preferred embodiment, the bacterial marker is CRP. In another preferred embodiment, the viral marker is MxA. In some embodiments, it is unnecessary to lyse the cells in the sample prior to applying it to the device.
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| Use of fibroblast growth factor for lineage priming and differentiation of pluripotent stem cells | 20130130375 | 20130523 |
| The present invention provides a method of inducing mesoderm derived cells from pluirpotent stem cells. In contrast to methods known in the art that are often designed to replicate in vivo events of mesoderm induction, the present invention provides a unique, yet simple, method whereby pluripotent stem cells are mesodermally primed in the presence of factors that concomitantly inhibit the spontaneous differentiation of endoderm and ectoderm during expansion and suspension steps. Exposure and/or adherence of primed aggregates to a extracellular matrix that promotes the commitment and survival of induced mesoderm progenitors, followed by exposure to various mesoderm associated factors, allows for the subsequent induction of such cells into terminally differentiated lineages, such as cardiomyocytes. End products of this induction system will ultimately provide an unlimited source... |
| Screening methods, compositions identified thereby, tools useful for the identification thereof, and cell populations produced thereby | 20130130376 | 20130523 |
| In accordance with one aspect of the present invention, methods have been developed for identifying compositions which support the culture of defined cell populations. In accordance with another aspect of the present invention, methods have been developed for identifying compositions which promote differentiation of defined cell populations. In accordance with yet another aspect of the present invention, methods have been developed for identifying compositions which induce apoptosis of defined cell populations. In accordance with still another aspect of the present invention, methods have been developed for identifying compositions which promote cell senescence of defined cell populations. In accordance with still another aspect of the present invention, methods have been developed for identifying media which modulate the retardation of cell growth of defined cell subpopulation(s). In accordance... |
| Apnea type determining apparatus and method | 20130131522 | 20130523 |
| An apnea classification system provides for apnea monitoring and differentiation based on several sleep apnea related parameters for diagnostic and therapeutic purposes. Monitoring of such sleep apnea related parameters allows the apnea classification system to differentiate among the different types of apnea and hypopnea and to identify an occurrence of periodic respiration. This information may then be used to determine the best method of therapy, or adjust current therapy parameters to more effectively treat a subject.
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| Method and system for differentiating drug delivery devices | 20130131601 | 20130523 |
| A method and system is disclosed for differentiating a drug delivery device that may be used to administer a plurality of drug types. The drug delivery system includes a drug delivery device and a differentiation shell. The drug delivery device holds a given medicament. A differentiation shell is attachable to the drug delivery device. The differentiation shell may include at least one shell-type feature configured to attach to a drug delivery device and at least one differentiation feature. The differentiation feature identifies the given medicament in the drug delivery device.
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| Differentiation of mesenchymal stem cells into fibroblasts, compositions comprising mesenchymal stem cell-derived fibroblasts, and methods of using the same | 20130121973 | 20130516 |
| Methods and compositions are provided for the differentiation and characterization of mammalian fibroblast from mesenchymal stem cells. The methods of the invention provide a means to obtain mesenchymal stem cell-derived fibroblast populations, e.g., seeded on a scaffold, which may be used in wound healing.
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| Drug delivery devices and growth factor formulations for accelerated wound healing | 20130122066 | 20130516 |
| The present invention is directed to novel drug delivery devices and pharmaceutical compositions containing growth and differentiation factor proteins. Said devices and compositions are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues. The invention is especially useful for the supportive therapy of diabetic wounds and ulcers.
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| Differentiation of mesenchymal stem cells into fibroblasts, compositions comprising mesenchymal stem cell-derived fibroblasts, and methods of using the same | 20130122521 | 20130516 |
| Methods and compositions are provided for the differentiation and characterization of mammalian fibroblast from mesenchymal stem cells. The methods of the invention provide a means to obtain mesenchymal stem cell-derived fibroblast populations, e.g., seeded on a scaffold, which may be used in wound healing.
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| Methods and compositions for labeling polypeptides | 20130122535 | 20130516 |
| Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms. Described herein are robust chemical methods for imaging and affinity-purifying nascent polypeptides in cells and in animals, based on puromycin analogs. Puromycin analogs of the present invention form covalent conjugates with nascent polypeptide chains, which are rapidly turned over by the proteasome and can be visualized and specifically captured by a bioorthogonal reaction (e.g., [3+2]cycloaddition). The methods of the present invention have broad applicability for imaging protein synthesis and for identifying proteins synthesized... |
| Method for inducing differentiation of human pluripotent stem cell into intermediate mesoderm cell | 20130122536 | 20130516 |
| The present invention relates to: a method for producing an intermediate mesoderm cell from a human pluripotent stem cell, comprising a step of culturing the human pluripotent stem cell in a medium containing Activin A and Wnt or a functional equivalent of Wnt and a step of culturing cells in a medium containing BMP and Wnt or a functional equivalent of Wnt; to a method for producing a metanephric cell from the intermediate mesoderm cell produced by the first method; to a human pluripotent stem cell having a foreign reporter gene in the chromosome wherein the gene is expressed interlocked with the expression of endogenous OSR1; to a method for screening for an inducer for differentiation into intermediate mesoderm using the human pluripotent stem cell; and... |
| Targeted differentiation of stem cells | 20130122589 | 20130516 |
| The invention provides a method of producing a mesodermal lineage progenitor cell, by 10 application of one or more factors selected from the group consisting of activin, Wnt, BMP, FGF, an inhibitor of activin, GDF and NT to a culture of undifferentiated stem cells for a period of time sufficient to differentiate a stem cell into a mesodermal lineage progenitor cell. The stem cell may be derived from a stem cell line, such as an embryonic stem cell line, for example HUES-1, HUES-7, HUES-8, MAN-1 or MAN-2. Also provided are cell 1 cultures, cells, matrices, kits and uses of the cell cultures and cells.
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| Use of regulatory sequences for specific, transient expression in neuronal determined cells | 20110016547 | 20110120 |
| The present invention relates to the use of regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells. Furthermore, the uses of recombinant nucleic acid molecules comprising said defined regulatory sequences for mediating specific, early transient expression in proliverative neuronal determined cells as well as for the generation of non-human transgenic organisms and/or host cells are disclosed. In addition, the invention provides for transgenic non-human animals and/or host cells comprising said regulatory sequences and/or recombinant nucleic acid molecules. The invention also describes methods for the preparation of such vectors, host cells and transgenic non-human animals as well as methods for the detection and/or isolation of neuronal determined cells. Additionally, methods for screening of compounds capable of regulating neuronal determined cell activity, neurogenesis, stimulating... |
| Methods and apparatus for the detection and differentiation of non-sialated proteins from sialated proteins in a fluid sample | 20110015089 | 20110120 |
| The present invention is directed to methods and devices for detection of cerebrospinal fluid leaks by detection of the CSF protein beta-2 transferrin. The microfluidic devices and methods of the invention combine capture and specific labeling of transferrin from a sample with a subsequent step of isoelectric focusing to separate transferrin isoforms for detection. Microfluidic channels and chambers are patterned on a substrate, designed so that on one region (i.e., a microfluidic channel or chamber) of the substrate transferrin is selectively captured from the sample and labeled, and in a second region of the susbstrate, transferrin isoforms are separated using isoelectric focusing. Detection of two transferrin bands, indicating the presence of beta-2-transferrin, indicates the presence of CSF in the sample. The devices and methods of the... |
| Differentiation of human embryonic stem cells | 20110014703 | 20110120 |
| The present invention provides methods to promote the differentiation of pluripotent stem cells into cells expressing markers characteristic of the pancreatic endocrine lineage that co-express PDX1, NKX6.1, but do not express CDX2 and NGN3.
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| Differentiation of human embryonic stem cells | 20110014702 | 20110120 |
| The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells capable of producing insulin following transplantation into an animal.
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| Protection of progenitor cells and regulation of their differentiation | 20110014701 | 20110120 |
| The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.
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| Method for producing dendritic cells | 20110014696 | 20110120 |
| Disclosed are embryonic stem cell-derived dendritic cells, genetically modified immature dendritic cells capable of maturation, as well as methods for the production of such cells. In one embodiment, the cells made be produced by a method comprising the steps of providing a population of embryonic stem cells; culturing the embryonic stem cells in the presence of a cytokine or combination of cytokines which brings about differentiation of the embryonic stem cells into dendritic cells; and recovering the dendritic cells from the culture. In a further embodiment, the cells may be genetically modified.
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| Method for generating primate cardiovascular progenitor cells for clinical use from primate embryonic stem cells or embryonic-like state cells, and their applications | 20110014691 | 20110120 |
| The present invention is directed to a method for the in vitro preparation of cardiovascular progenitors cells from mammalian embryonic stem cells (ES cells) or mammalian embryonic-like state cells, preferably from primate, wherein said method comprises the use of the CD15 (SSEAI) marker as a positive cardiovascular progenitors differentiation marker. The present invention also claimed the use of a receptor tyrosine kinase inhibitor, particularly the SU5402 or SU11248 in association with the BMP2 for improving the efficiency of the desired differentiation. The present invention is also directed to the use of platelet lysate as foetal animal serum substitute in a culture medium intended to the proliferation or propagation of primate ES cells maintaining their pluripotency feature. Derived compositions or kits in relation with the claimed methods... |
| Compositions and methods for inhibiting or inducing adipogenesis | 20110014275 | 20110120 |
| This invention relates generally to compositions and methods which utilization nuclear receptors for regulating adipogenesis in cells. Specifically, the invention is directed to compositions which regulate transcription factor PPARγ, and enhance or inhibit the transcription of genes responsible for directing cell differentiation towards a pathway of adipogenesis. More specifically, disclosed herein is a novel polypeptide coactivator of PPARγ, and fragments thereof, which possess coactivator or corepressor activity. Also related are nucleotide sequences which express these polypeptides. Also disclosed is an interfering RNA that may be used to inhibit adipogenesis.
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| Microvesicles | 20110014251 | 20110120 |
| A method of producing a population of differentiated cells comprising: a) inducing differentiation in a first population of cells by applying an inducer to said cells, b) harvesting microvesicles produced from first population of cells, and c) inducing differentiation in a second population of cells by applying said microvesicles or a derivative thereof to said second population of cells wherein, said first population of cells is autologous to said second population of cells and wherein the inducer applied to said first population of cells is not present in said second population of cells or is only present in trace amounts. Also related methods of producing microvesicles, methods of medical and/or cosmetic treatment and related products and uses.
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| Differentiation of human embryonic stem cells | 20110014163 | 20110120 |
| The present invention provides a method for lowering blood glucose levels in an animal by transplanting a population of pancreatic endocrine precursor cells into an animal.
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| Composition for skin external application containing complex of herbal extracts | 20110014149 | 20110120 |
| Disclosed is a combination for skin external use, which contains as an active ingredient an herbal extract complex consisting of Chinese herbal extracts of Granate bark, seed of Prunus armeniaca, Coix lacuma-jobi, Saururus chinensis and Perilla frutescens var. aceta. More particularly, disclosed is a composition for skin external use containing an herbal extract complex, which is prepared by mixing the Chinese herbs with each other at an optimal ratio to prepare an herbal mixture and extracting the herbal mixture to prepare an herbal extract complex, and thus shows the effects of promoting the differentiation of skin keratinocytes, restoring impaired skin barrier function and increasing skin moisturization compared to extracts obtained by extracting each of the herbs alone.
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| Method for reprogramming in vitro stem cells and somatic cells into germinal cells | 20110010783 | 20110113 |
| Germinal cells such as obtained and chimeric animals are also an object of this invention.
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| Method of producing a mouse suitable for engraftment, differentiation and proliferation of heterologous cells, mouse produced by this method and use of the mouse | 20110010781 | 20110113 |
| The present invention provides an immunodeficient mouse (NOG mouse) suitable for engraftment, differentiation and proliferation of heterologous cells, and a method of producing such a mouse. This mouse is obtained by backcrossing a C.B-17-scid mouse with an NOD/Shi mouse, and further backcrossing an interleukin 2-receptor γ-chain gene-knockout mouse with the thus backcrossed mouse. It is usable for producing a human antibody and establishing a stem cell assay system, a tumor model and a virus-infection model.
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| Mirna, sirna and use thereof in therapy | 20110009468 | 20110113 |
| The present invention relates to a mixture of molecules comprising at least one miRNA and at least one siRNA, or at least two miRNAs, or at least two siRNAs for inducing hematopoietic differentiation or for treating leukemia wherein the miRNA is able to modulate hematopoietic differentiation and/or to act as oncosuppressor, and the siRNA is able to modulate hematopoietic differentiation or to inhibit the expression of a fusion product deriving from a chromosomic translocation associated to leukemia.
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| Synthesis and biological activities of new tricyclic-bis-enones (tbes) | 20110009363 | 20110113 |
| This invention describes novel tricyclic-bis-enone derivatives (TBEs), such as TBE-31, TBE-34, TBE-45 and water-soluble TBEs. The methods of preparing these compounds are also disclosed. The inventors demonstrate the ability of these new TBEs to inhibit proliferation of human myeloma cells, inhibit the induction of iNOS in cells stimulated with interferon-γ, induce heme oxygenase-1 (HO-1), induce CD11b expression—a leukemia differentiation marker, inhibit proliferation of leukemia cells, induce apoptosis in human lung cancer, and induce apoptosis in other cancerous cells. The TBEs of this invention are expected to be useful agents for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.
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| Medium for mammalian somatic cells and additive therefor | 20110008893 | 20110113 |
| Disclosed are a medium for mammalian somatic cells with which mammalian somatic cells can be grown effectively when the mammalian somatic cells are cultured, while reducing the amount of serum to be added to the medium as much as possible or without adding serum thereto, and an additive to constitute the medium. By blending of a ligand for an endothelial cell differentiation gene (Edg) family receptor and a ligand for a serotonin receptor to a medium, somatic cells of mammals can be grown even in cases where the medium does not contain serum at all or contains only a small amount thereof.
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| Method of differentiating stem cells | 20110008819 | 20110113 |
| There is provided an improved efficient method for differentiating stem cells into pancreatic endoderm cells and pancreatic hormone expressing and secreting cells which express Pdx-1 and C-peptide. The invention further provides screening methods for detecting factors of interest that will affect the differentiation of the stem cells into pancreatic endoderm cells.
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| Methods and compositions for identifying undifferentiated stem cells and assessing cell health | 20110008784 | 20110113 |
| Disclosed herein are methods and compositions for the identification of teloRNA marks to assess the differentiation status of an individual stem cell or a population of stem cells, to diagnose whether and to what extent a stem cell or stem cell culture has already initiated cell differentiation, and to monitor the differentiation status of an individual stem cell or a stem cell culture during passage. The use of these methods and compositions to monitor the pluripotency and differentiation status of a stem cell or stem cell culture during differentiation enables the identification of undifferentiated and pluripotent stem cells prior to the initiation of differentiation. The methods and compositions can also be used to assess and maintain cell viability; to identify cells or a population of cells... |
| Method of drug delivery | 20110008446 | 20110113 |
| A drug delivery method for effective drug application is disclosed in this invention. In this method, a micro-carrier delivers an encapsulated, desired drug directly to targeted sites without significant interactions with other components in the biological system in the pathway. In one embodiment, a micro-carrier containing encapsulated drug is first delivered to the general area for treatment. It then scans the area and selectively attaches itself the cell site or organ location to be treated. Finally, the desired drug contained in the micro-carrier is released to the attached cell or organ. In another embodiment, a micro-device is first used to process the general area to be treated to enhance differentiation in properties (such as surface charge) between healthy cells and unhealthy cells (such as cancer cells).... |
| Methods of and compositions for inhibiting the proliferation of mammalian cells | 20110008314 | 20110113 |
| A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
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| Human adipose derived insulin making mesenchymal stem cells for treating diabetes mellitus | 20110008301 | 20110113 |
| The invention provides a novel therapeutic composition comprising of insulin producing mesenchymal stem cells obtained from human adipose tissue along with Hematopoietic stem cells for the treatment of diabetic patients especially insulinopenic patients. The invention also describes a simple and efficient process for the isolation, proliferation and differentiation of insulin producing mesenchymall stem cells from human adipose tissue. Unfiltered extract of adipose tissue is used in the process with a medium totally free from xenogenic material; the serial passages of the cells are avoided in the process.
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| Muscle-derived cells having differentiation capacities | 20110008296 | 20110113 |
| The present application also relates to the biotechnological and medical applications of these cell populations, notably in the field of cell and tissue therapy.
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| Methods of skin whitening and of screening skin-spot-formation inhibiting and/or skin-spot removing factor | 20110008273 | 20110113 |
| A method of skin whitening is provided which includes: selectively activating proliferation and/or differentiation of melanin-containing keratinocytes of the skin.
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| Compositions and methods for osteogenic gene therapy | 20110004947 | 20110106 |
| The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth. For example, the disclosure provides recombinant nucleic acids that encode a fibroblast growth factor-2 (FGF-2) analog. The disclosure also provides vectors and cells incorporating these nucleic acids, as well as FGF-2 analogs encode by them. The disclosure also provides a mouse system of bone marrow transplantation and methods for producing as well as methods for using the system. Methods for inducing division and/or inducing differentiation of a hematopoietic stem cell are also provided, as are methods for enhancing bone growth and/or wound repair (for example, fracture repair).
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| Interference prevention control device of work machine | 20110004379 | 20110106 |
| The present invention provides an interference prevention control device of a work machine, wherein the interference prevention control device is capable of preventing interference between the cab and a tool of the work equipment regardless of whether either one of the cab or the work equipment is moved while the other is being operated, and thereby improving operation efficiency of the work machine. With regard to a work machine provided with a movable cab, a cab position sensor for detecting a cab position, as well as a boom angle sensor and an arm angle sensor for detecting a position of a tool at the distal end of the work equipment, are connected to a controller. Solenoid-operated directional control valves for limiting the movement of a boom... |
| Dermatological compositions comprising retinoids, dispersed benzoyl peroxide and carrageenans | 20110003894 | 20110106 |
| Dermatological compositions containing, in a physiologically acceptable medium, at least one retinoid, dispersed benzoyl peroxide and at least one gelling agent of the family of the carrageenans, are useful for treating dermatological conditions and afflictions linked to disorders of cell differentiation and/or proliferation and/or keratinization, notably for treating acne vulgaris.
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| Compositions and methods for disrupting the function of the transcriptional repressor component sin3a-pah2 domain to induce differentiation and growth inhibition in breast cancer | 20110003753 | 20110106 |
| The present invention relates, generally, to compositions for treating breast cancer, use of the compositions to sensitize breast cancer cells to treatment, and methods for treating breast cancer by administering the compositions. The compositions comprise peptides derived from the mSin3A interaction domain (SID) and derivatives thereof, as well as small molecule inhibitors (SMIs) capable of interfering with interactions between SID and the paired amphipathic helix domain 2 (PAH2) domain of the transcription repressor Sin3A. The present invention further relates to compositions for treating triple-negative breast cancer, use of the compositions to render the breast cancer cells susceptible to treatment using hormonal therapies and HER2-based therapies, and methods for treating triple-negative breast cancer by administering the compositions.
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| Methods, systems, and kits for identification of osteoinductive peptides | 20110003702 | 20110106 |
| Methods and systems for obtaining and identifying ligands that bind to cells and effect differentiation and/or support growth are provided herein. Several ligands were identified as proof of efficacy of the methods and systems, and amino acid sequences of compositions that effect differentiation of osteoblasts are thereby obtained.
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| Loss differentiation based management of wireless networks | 20110003612 | 20110106 |
| Implementations of loss differentiation based management of wireless networks are disclosed.
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| Method of producing erythrocytes without feeder cells | 20110003387 | 20110106 |
| Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place.
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| Secreted proteins as markers for cell differentiation | 20090328243 | 20091231 |
| Provided are means and methods for in vitro and in vivo detection of chemically induced effects on embryonic development and differentiation for the purpose of embryotoxicity/teratogenicity screening as well as for the identification of pharmaceuticals such as growth and tissue promoting factors based on differentiating pluripotent embryonic stem (ES) cells. The assays are based on the use of transgenic ES cells and non-human animals comprising such ES cells or derivatives thereof, wherein said ES cells are characterized by the differentiation-dependent expression of a secreted reporter protein; in particular secreted embryonic alkaline phosphatase (SEAP).
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| Remote computing session feature differentiation | 20090327498 | 20091231 |
| Example embodiments of the present disclosure are related to terminal servers. In an example embodiment a license can be associated with, or define, a set of capabilities and a session can be generated that includes the capabilities. In an example embodiment the session can be generated in view of a license and privileges that are associated with an account identifier of a user requesting a session from a terminal server.
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| Use of galactose c-glycoside derivatives as protective agent and/or gama delta t lymphocyte activator | 20090325890 | 20091231 |
| The composition will find applications for promoting skin tissue repair, for reequilibrating epidermal proliferation and differentiation disorders which appear with lack of sleep, and for improving the appearance of the head of hair and limiting hair loss.
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| Detection method | 20090325810 | 20091231 |
| The present invention relates generally to an array of nucleic acid molecules, the expression profiles of which characterise the anatomical origin of a cell or population of cells within the large intestine. More particularly, the present invention relates to an array of nucleic acid molecules, the expression profiles of which characterise the proximal or distal origin of a cell or population of cells within the large intestine. The expression profiles of the present invention are useful in a range of applications including, but not limited to determining the anatomical origin of a cell or population of cells which have been derived from the large intestine. Still further, since the progression of a normal cell towards a neoplastic state is often characterised by phenotypic de-differentiation, the method... |
| Method for inducing differentiation of pluripotent stem cells into cardiomyocytes | 20090325288 | 20091231 |
| A method for inducing differentiation of cardiomyocytes from pluripotent stem cells, which comprises: (i) culturing the pluripotent stem cells in a culture medium containing no substance that promotes activation of the canonical Wnt signaling pathway during the time period between initiation of differentiation induction and 24 hours before the period of elevated canonical Wnt gene expression; and then (ii) culturing the pluripotent stem cells in a culture medium containing a substance that promotes activation of the canonical Wnt signaling pathway during a time period of 24 to 96 hours, starting from 24 to 0 hours before the period of elevated canonical Wnt gene expression.
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| Drug screening using islet cells and islet cell progenitors from human embryonic stem cells | 20090325180 | 20091231 |
| This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells. High quality populations of islet cells can be produced in commercial quantities for use in research, drug screening, or regenerative medicine.
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| Detection and distinguishing infections bursal disease virus (ibdv) strains by molecular biology method | 20090325149 | 20091231 |
| The present invention relates to a novel method to detect and differentiate different strains of infectious bursal disease virus (IBDV) in a chicken and other bird sample. RNA was obtained from said samples by using a pair of primer (Primer FVVC & RVVC) in a reverse transcriptase-polymerase chain reaction. Two different primer combinations (Primer IF & IVIR) and (Primer IF & RCLA) and real-time polymerase chain reaction conditions were designed and optimized for rapid differentiation of very virulent and vaccine strains of IBDV based on detection of signatory threshold cycle (Ct) and melting temperature (Tm) values.
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| Methods for inducing the differentiation of hematopoietic stem cells into megakaryocytes and platelets, and gene controlling the differentiation | 20090324583 | 20091231 |
| The present invention relates to a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets, more particularly, a method for inducing the differentiation of CD34+ hematopoietic stem cells into megakaryocytes and platelets comprising the steps of coculturing CD34+ hematopoietic stem cells with stromal cells and adding the compound of Formula 1. Further, the present invention relates to a composition for detecting the differentiation of hematopoietic stem cells into megakaryocytes and platelets, comprising an agent measuring expression level of a gene that is selected from the group consisting of KLF2 (Kiruppel-like factor2), LOC138255 (OTTHUMP00000021439), GDF15 (growth differentiation factor 15) and INHBE (inhibin, betaE), a kit comprising the composition, a method for detecting the differentiation into megakaryocytes and platelets by using the marker... |
| Cells exhibiting neuronal progenitor cell characteristics and methods of making them | 20090324561 | 20091231 |
| Disclosed are cells exhibiting neuronal progenitor cell characteristics, and methods of making them from marrow adherent stem cells by regulating cellular pathways in the marrow adherent stem cells that are associated with glial transdifferentiation of the marrow adherent stem cells.
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| Device and method for real-time mark of substance identification system | 20090323894 | 20091231 |
| Disclosed are a method and a device for real-time mark for a high-energy X-ray dual-energy imaging container inspection system in the radiation imaging field. The method comprises the steps of emitting a first main beam of rays and a first auxiliary beam of rays having a first energy, and a second main beam of rays and a second auxiliary beam of rays having a second energy; causing the first and second main beams of rays transmitting through the article to be inspected; causing the first and second auxiliary beams of rays transmitting through at least one real-time mark material block; collecting values of the first and second main beams of rays that have transmitted through the article to be inspected as dual-energy data; collecting values of... |
| Benzothiophene hydroxamic acid derivatives with carbamate, urea, amide and sulfonamide substitutions | 20090318541 | 20091224 |
| The present invention relates to a novel class of hydroxamic acid derivatives carbamate, urea, amide and sulfonamide substitutions. The hydroxamic acid compounds can be used to treat cancer. The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells. Thus, the compounds of the present invention are useful in treating a patient having a tumor characterized by proliferation of neoplastic cells. The compounds of the invention are also useful in the prevention and treatment of TRX-mediated diseases, such as autoimmune, allergic and inflammatory diseases, and in the prevention and/or treatment of diseases of the central nervous system (CNS), such as neurodegenerative diseases. The... |
| Methods and nucleic acids for the detection of colorectal cell proliferative disorders | 20090317810 | 20091224 |
| The invention provides methods, nucleic acids and kits for detecting, or for distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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| Composition containing arazyme for the prevention and treatment of cancer | 20090317374 | 20091224 |
| The present invention relates to a pharmaceutical composition for the prevention and treatment of cancer comprising arazyme as an active ingredient. More precisely, when arazyme produced by Aranicola proteolycius was administered to the nude mice transplanted with human lung carcinoma cell line, weight gaining, inhibition of tumor cell growth and infiltration, and down-regulations of MMP-9, NF-κB and PCNA, were observed. In addition, when arazyme was treated to human breast cancer cells (MDA-MB-231), down regulations of p21, PCNA (Proliferating Cell Nuclear Antigen), VEGF (Vascular Endothelial Growth Factor), BCl2 (B-cell CLL/lymphoma 2), p-p38, PKC (Protein Kinase C) and MMP-1 (Matrix MetalloProteinase-1) which are involved in tumor cell growth, differentiation, proliferation and metastasis, were observed along with the up-regulation of catalase which inhibits tumor development. Therefore, the arazyme can... |
| Systems and methods for making hepatocytes from extrahepatic somatic stem cells and use thereof | 20090317365 | 20091224 |
| A method for making hepatocytes from extrahepatic somatic stem cells comprises: a) culturing somatic stem cells in a medium comprising hepatic growth factor to cause the stem cells to differentiate toward hepatocytes; b) culturing cells from a) in a medium comprising HGF and oncostatin M to facilitate the cell differentiation toward hepatocytes; and c) culturing cells from b) in a medium comprising oncostatin M to cause the differentiated cells to mature into hepatocytes, thereby producing a cell population that has morphological features of hepatocytes and at least four of the following characteristics: i) antibody-detectable expression of albumin; ii) real-time reverse transcriptase-polymerase chain reaction-detectable expression of α-fetoprotein, HNF-1α, HNF-3β, HNF-4, HNF-6, α1-antitrypsin, alkaline phosphatase, tryptophan 2,3-dioxygenase, tyrosine aminotransferase, cytochrome P450 family 2 subfamily E polypeptide 1, glutamine... |
| Methods of regulating differentiation in mammals | 20090312251 | 20091217 |
| Mechanisms regulating cell proliferation stop and differentiation initiation during the development stage of mammalian embryo, and the proteins involved therein, are presented. Differentiation regulators, methods of regulating differentiation, transgenic organisms with loss of expression of the differentiation regulator, and methods of preparing the transgenic organisms, are provided.
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| Tlr4 decoy receptor protein | 20090312249 | 20091217 |
| The present application discloses a nucleic acid molecule encoding a fusion polypeptide capable of binding myeloid differentiation protein-2 (MD-2) polypeptide, which includes: a nucleotide sequence encoding an MD-2 polypeptide-binding portion of human toll-like receptor 4 (TLR4), a leucine-rich repeats (LRR) module, and a multimerizing component.
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| Method for preparing differentiated avian cells and genes involved in maintaining pluripotency | 20090311789 | 20091217 |
| The present invention relates to a method for preparing differentiated avian cells from stem cells in culture. Genes involved in maintaining the pluripotency of avian stem cells were identified and cloned. By inhibiting the expression of these genes in stem cells, the latter lose their pluripotency characteristics and enter into differentiation. These differentiated cells obtained in vitro can serve as host cells for pathogens, in particular viruses, and can thus be used for the production of antiviral vaccines.
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| Method for promoting differentiation of stem cell into insulin producing cell | 20090311782 | 20091217 |
| A method for promoting a differentiation of stem cells into insulin producing cells is provided. The method includes steps of suspending the stem cells in a first culture medium, aggregating the stem cells to form a cell pellet, and culturing the cell pellet in a second culture medium to promote the differentiation of the stem cells of the cell pellet into the insulin producing cells.
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| Alginate poly-l-lysine encapsulation as a technology for controlled differentiation of embryonic stem cells | 20090311765 | 20091217 |
| Alginate polyelectrolyte encapsulation is used for the controlled differentiation of embryonic stem cells. An isolated cell population is provided. The cell population includes a single cell suspension of ES cells encapsulated within an alginate polyelectrolyte microenvironment. The encapsulated ES cells are capable of differentiating within said microenvironment into hepatocyte lineage cells in the absence of embryoid body intermediates or growth factor supplementation.
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| Laser illumination system in fluorescent microscopy | 20090311734 | 20091217 |
| Devices and methods for automated collection and image analysis are disclosed that enable identification or classification of microscopic objects aligned or deposited on surfaces. Such objects, e.g. detectably labeled rare target cells, are magnetically or non-magnetically immobilized and subjected to Time Delay Integration imaging (TDI). Incorporation of TDI technology into image cytometry analysis, like CellTracks®, makes it possible to image moving objects with very high sensitivity and signal-to-noise ratios. Implementation of TDI camera technology with dual excitation and multispectral imaging of enriched rare cells provides a rapid system for detection, enumeration, differentiation and characterization of imaged rare cells on the basis of size, morphology and immunophenotype.
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| Methods for identifying factors for differentiating definitive endoderm | 20090311703 | 20091217 |
| Disclosed herein are methods of identifying one or more differentiation factors that are useful for differentiating cells in a cell population comprising definitive endoderm cells into cells which are capable of forming tissues and/or organs that are derived from the gut tube.
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| Methods for treating tweak-related conditions | 20090311313 | 20091217 |
| The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.
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| Biocompatible transparent sheet, method for producing the same, and cultured cell sheet used the same sheet | 20090311297 | 20091217 |
| The present invention provides a flexible, biocompatible transparent sheet (8) which has high biocompatibility and a high ability to adsorb a biologically relevant substance, which can be used as a novel biomaterial, and which can be used to observe the propagation, differentiation, and/or the like of living cells in real time. The biocompatible transparent sheet (8) is produced in such a manner that a biocompatible ceramic film (2) is formed on a substrate (1) soluble in a solvent (11) incapable of dissolving biocompatible ceramics by using exemplary a laser ablation process, the substrate (1) depositing the film (2) is dipped in the solvent (11) and dissolved off, and the isolated film (2) is then dried. The biocompatible transparent sheet (8) is utilizable of producing a flexible... |
| Screening method | 20090311244 | 20091217 |
| This invention relates to a novel screening method that identifies simple molecular markers that are predictive of whether a particular disease condition is responsive to a specific treatment. Also, a method of diagnosing the susceptibility of an individual suffering from a disease to treatment with an HDAC inhibitor is provided. Also provided is a method of treating a proliferative disease or a condition which involves a change in cell differentiation or growth rate in a patient.
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| Optical film, its manufacturing method, anti-glare polarizer using the same, and display apparatus | 20090310219 | 20091217 |
| An anti-glare film is provided and includes micro concave/convex portions on a surface. An average interval between the micro concave and convex portions is equal to 300 μm or less. A differentiation with respect to angle d{Log(I(α))}/dα of a logarithm intensity of reflection Log(I(α)) in a direction of a deviation angle α from a direction of specular reflection has an extreme value. A differentiation d{Log(P(β)}/dβ of a histogram P(β) to an inclination angle β of the micro concave/convex portions has an extreme value. In the anti-glare film 1, a value C(2.0) of transmitted image clarity measured by using an optical comb of a comb width of 2 mm in accordance with JIS-K7105 is equal to 30% or more, and a ratio C(0.125)/C(2.0) of the value C(2.0)... |
| Superparamagnetic nanoparticles based on iron oxides with modified surface, method of their preparation and application | 20090309597 | 20091217 |
| The preparation of labelled cells proceeds by adding to the complete culture medium 5-20 μl, to advantage 10 μl, of a colloid containing 0.05-45 mg iron oxide per ml, to advantage 1-5 mg iron oxide per ml of the medium, and culturing the cells for a period of 1-7 days, to advantage for 1-3 days, at 37° C. and 5% of CO2.
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| In-kernal content-aware service differentiation | 20090307350 | 20091210 |
| The increasing number of Internet users and innovative new services such as e-commerce are placing new demands on Web servers. It is becoming essential for Web servers to provide performance isolation, have fast recovery times, and provide continuous service during overload at least to preferred customers. The invention describes a kernel-based architecture for content-aware service differentiation that protects Web servers against overload by controlling the amount and rate of work entering the system. We have invented a mechanism that provides admission control and service differentiation based on connection and application level information. The application header-based connection control uses application-level information (such as URIs and cookies for HTTP) to define different service differentiation actions. The present invention provides the kernel mechanisms that are more efficient and scalable... |
| Method and apparatus for representing multidimensional data | 20090307248 | 20091210 |
| The present invention relates to methods for representing multidimensional data. The methods of the present invention are well suited but not limited to the representation of multidimensional data in such a way as to enable the comparison and differentiation of data sets. For example, the invention may be applied to the representation of flow cytometric data. The invention further relates to a program storage device having instructions for controlling a computer system to perform the methods, and to a program storage device containing data structures used in the practice of the methods.
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| Modulators of itch ubiquitinase activity | 20090306187 | 20091210 |
| The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the E3 ubiquitin ligase, Itch, as a means for treating disorders. Furthermore, the present invention relates to the regulation of p63 and p73 stability in cells. In particular, the invention relates to the modulation of the regulation of p63 and p73 stability in cells through modulation of the expression or activity of Itch. Moreover, the invention relates to the use of Itch as a target for the development of agents capable of modulating p63 or p73 stability and especially agents capable of modulating the interaction of Itch and p63 or p73. Such agents may be useful in therapeutic applications including... |
| Compounds capable of affecting differentiation, proliferation, regeneration, plasticity and survival cells | 20090305951 | 20091210 |
| The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3,1) module, and/or the second Fibronectin III (Fn3,2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with an Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.
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| Cell differentiation of adipose-derived precursors cells | 20080317718 | 20081225 |
| The present invention provides a simple method for controlled differentiation of adipose-derived precursor cells. A method is provided for preparing a differentiated cell. The method comprises A) obtaining a mixture by mixing a) an adipose-derived precursor cell and b) a differentiated cell corresponding to a desired site; and B) culturing the mixture under sufficient conditions which allow the adipose-derived precursor cell to differentiate. The present invention also provides a composition for cell implantation comprising a) an adipose-derived precursor cell and b) a differentiated cell corresponding to a desired site.
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| Fat-derived progenitor cell and use thereof | 20080317720 | 20081225 |
| An objective of the present invention is to provide methods for producing progenitor cells which show a high proliferation ability ex vivo and promote neovascularization or myocardium regeneration, by culturing pluripotent cells in a medium containing adrenomedullin (AM) and/or vascular endothelial growth factor (VEGF). Moreover, another objective of the present invention is to provide the progenitor cells and uses thereof. In order to solve the above problems, the inventors of the present application have successfully developed a novel culture technique for producing progenitor cells from adipose tissues more efficiently compared to the conventional techniques, by using adrenomedullin (AM) and/or vascular endothelial growth factor (VEGF). The progenitor cells produced by the present inventors are specialized cells having a potent proliferation ability, a revascularization ability, and a myocardium... |
| Reverse-flow perfusion of three-dimensional scaffolds | 20080318315 | 20081225 |
| The invention is a reverse-flow method and system for the loading, proliferation and differentiation of cells into and throughout an implantable biocompatible three-dimensional scaffold.
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| Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same | 20080318316 | 20081225 |
| A method is provided for controlling the survival, proliferation, and/or differentiation of hepatic progenitors in vitro by using specific types of mesenchymal feeder cells or one of more of the paracrine signals produced by those feeders.
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| Scd fingerprints | 20080318836 | 20081225 |
| The present invention relates to the use of cluster of differentiation (CD) molecules in detecting the presence and progression of one or more disease states in an individual. In particular it relates to the use of profiles of shed CD (sCD) molecules in detecting an assessing the progress of one or more disease states in an individual. Further uses of sCD profiles according to the present invention are also described.
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| Acceleration control system | 20080319628 | 20081225 |
| An acceleration control system stores a target acceleration calculation equation acquired by transforming an equation that expresses that a product of the differentiation of the square power of the speed and the environmental factor αenv represents a sensed value ε of acceleration. A surrounding environment monitor device detects surrounding bodies present in the forward periphery of the vehicle, and an environmental factor calculation unit calculates the environmental factor αenv by using the detected positions of the surrounding bodies. A target acceleration setting unit successively sets target accelerations aref in compliance with the target acceleration calculation equation by using the environmental factor αenv. The acceleration is executed to match the driver's feeling.
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| Isolated liver stem cells | 20080311094 | 20081218 |
| Isolated liver progenitor stem cells and cell populations of isolated liver progenitor stem cells are disclosed. The progenitor stem cells originate from adult liver, especially human adult liver. The isolated progenitor stem cells have uses in medicine, hepatology, inborn errors of liver metabolism transplantation, infectious diseases and liver failure. Methods of isolating these cells and their culture is described. The isolated cells are characterized before and after differentiation. Their use for transplantation and as animal models of human disease, toxicology and pharmacology is disclosed.
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| Use of morphogenic proteins to treat human disc disease | 20080311114 | 20081218 |
| Bone morphogenetic proteins (BMPs) are introduced into an affected intervertebral disc without the inclusion of disc cells. The inventions applies to all known and yet-to-be developed or discovered BMPs, including BMP-1, -2, -3, -4, -5, -6, -7, -8, -9, -10, . . . BMPn. The BMP(s) may be obtained from natural and/or recombinant sources. The BMP(s) may be introduced using any surgical technique, including percutaneous or laparoscopic approaches. As one delivery mechanism, a passageway may be formed through the annulus, with the substances then being introduced through the passageway. Alternatively, a carrier may be sewn or otherwise adhered to the inside or outside of the existing annulus using standard surgical procedures. Additional therapeutic substances such as culture medium, growth factors, differentiation factors, hydrogels, polymers, antibiotics, anti-inflammatory... |
| Method for quantification of methylated dna | 20080311566 | 20081218 |
| The present invention relates to a method for the quantification of methylated cytosines in DNA. In the first step of the invention unmethylated cytosines in the DNA to be analysed are chemically converted into uracil while 5-methylcytosines remain unchanged. In a second step the converted DNA is amplified methylation specifically in a real time PCR using a methylation specific probe. Finally the amount of uniformly methylated DNA is calculated by combining criteria derived from the shape of the real time curve and from the signal intensity. The method is preferably used for diagnosis and/or prognosis of adverse events for individuals, for distinguishing cell types and tissues, or for investigating cell differentiation.
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| Methods for detection of mutations in myostatin variants | 20080311584 | 20081218 |
| Methods for detecting allelic variants of the myostatin (growth and differentiation factor-8) gene are provided. Specifically provided are methods of identifying subjects having or having a predisposition for increased muscle mass as compared to subjects having wild-type myostatin. Increased muscle mass is particularly desirable for identification of animals used to produce food products, including bovine, porcine, ovine, avian and piscine species.
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| Methods and compositions for regulation of stem cell survival, proliferation, and differentiation by protein ubiquitination | 20080311607 | 20081218 |
| Compositions and methods for regulating in vitro cell growth are disclosed, and for providing undifferentiated stem cells or embryonic cells that are suitable for transplantation into damaged tissues or organs, or for use in tissue repair. A representative method includes causing the overexpression or underexpression of GalT binding protein (GtBP), also referred to as GalT associated protein (GTAP), in a cell such that ubiquitination of at least one cellular protein associated with cell adhesion and/or cell-to-cell interaction is correspondingly increased or decreased, causing inhibition of cell growth when GTAP is overexpressed and causing enhanced cell growth when GTAP is underexpressed by the cell. As a result, growth of the cell is altered or regulated.
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| Agent for regulating bone formation | 20080312145 | 20081218 |
| The present invention provides preventive, ameliorating, and/or therapeutic agents for diseases caused by a disturbed balance between bone formation and bone resorption. The decoys of the present invention induce normal bone metabolism by inhibiting the differentiation-inducing factors of cells involved in bone metabolism. For example, bone resorption can be controlled by using a decoy of the present invention to inhibit NF-κB, a transcriptional regulatory factor that regulates osteoclast differentiation. This method uses a mechanism different from those of previous pharmaceutical agents; therefore, one can expect it to be effective for cases in which existing pharmaceutical agents were not effective.
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| Treatment and analysis of proliferative disorders | 20080312150 | 20081218 |
| A method of treating a subject having unwanted cell proliferation which includes: inducing differentiation in a cell; providing said cell with a photosensitizer; and activating said PS, thereby the treating unwanted cell proliferation.
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| Semaphorin gene family | 20080312158 | 20081218 |
| A novel class of proteins, semaphorins, nucleic acids encoding semaphorins, semaphorin peptides, and methods of using semaphorins and semaphorin-encoding nucleic acids are disclosed. Semaphorin peptides and receptor agonists and antagonists provide potent modulators of nerve cell growth and regeneration. The invention provides pharmaceutical compositions, methods for screening chemical libraries for regulators of cell growth/differentiation; semaphorin gene-derived nucleic acids for use in genetic mapping, as probes for related genes, and as diagnostic reagents for genetic neurological disease; specific cellular and animal systems for the development of neurological disease therapy.
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| Method for determining enantiomeric purity of darifenacin and intermediates | 20080312455 | 20081218 |
| including the differentiation and quantification of compounds of formula (I) of varying enantiomeric purity from their corresponding enantiomers. The invention further relates to a process for preparing enantiomerically pure darifenacin using enantiomerically pure starting compounds which have been previously differentiated and quantified according to the method of the invention.
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| Method for differentiating mesenchymal stem cells into steroid-producing cells | 20080313752 | 20081218 |
| To control the differentiation of mesenchymal stem cells into steroid hormone producing cells. Mesenchymal stem cells can be differentiated into steroid hormone-producing cells by being stimulated by a transcriptional factor (SF-1), preferably by the transcriptional factor (SF-1) and cAMP. The present invention is a method for differentiating mesenchymal stem cells into steroid hormone producing cells, comprising stimulating the mesenchymal stem cells by the transcriptional factor (SF-1). The mesenchymal stem cells may be further stimulated by cAMP.
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| Method of inducing memory b cell development and terminal differentiation | 20080305076 | 20081211 |
| A method is disclosed herein for inducing differentiation of a B cell progenitor into a memory B cells and/or a plasma cell. The method includes contacting a population of cells including a mature B cell or a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. In one embodiment, the B cell progenitor is an immature B cell. A method is also disclosed for enhancing an immune response. The method includes contacting a population of cells including a B cell progenitor with an effective amount of IL-21, and isolating memory B cells or plasma cells. The memory B cells and/or the plasma cell are then introduced into the subject to enhance the immune response. A method is also... |
| Genetic methods for speciating campylobacter | 20080305484 | 20081211 |
| Species-specific identification of campylobacters is problematic, primarily due to the absence of suitable biochemical assays for their differentiation and the existence of atypical strains. The phylogeny of twelve Campylobacter species was studied based on partial (1020-bp) gyrB gene (DNA topoisomerase beta-subunit gene) sequences. The topology of the resulting phylogenic neighbor-joining tree based on the gyrB gene was similar to that of the topology of a previously reported phylogenic tree based on the 16S rDNA gene. However, gyrB provides a better resolution than the 16S rDNA gene for Campylobacter species with interspecies sequence similarities ranging from 58.3 to 89.2%. A universal primer set, designed to amplify a 960-bp fragment of the gyrB gene in Campylobacter spp., was developed and used for PCR restriction fragment length polymorphism (PCR-RFLP)... |
| Method of producing nerve cell | 20080305544 | 20081211 |
| An Object of the present invention is to provide a process for producing a nerve cell by inducing differentiation of an embryonic stem cell, a method for inducing differentiation of the embryonic stem cell into a nerve cell, a medium to be used in the production process or differentiation induction method, or a method for improving purity of the nerve cell obtained by inducing differentiation of the embryonic stem cell. The present invention provides a process for producing a nerve cell which is applicable to treatment of neurodegenerative disease or the like easily, selectively or inexpensively by inducing differentiation induction of an embryonic stem cell using vitamin B12 or a salt thereof and heparin, a substance having heparin-like activity or a salt.
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| Shape memory thermoplastics and polymer networks for tissue engineering | 20080305545 | 20081211 |
| Methods and compositions are described herein for reconstruction of different functional tissues. Dissociated cells, differentiated cells, adult mesenchymal stem cells or embryonic stem cells are seeded on a scaffold. The scaffold will consist of a biocompatible, biodegradable shape memory (“SM”) polymers. In addition bioactive substances may be incorporated in the scaffold. Thermoplastic as well as thermoset materials with SM-effect can be used. The shape memory effect will be applied as an interactive link between the cells and the used polymeric scaffold. The degradation kinetics as well as shape memory transition temperature will be tailored by adjusting to monomer ratios of the co-oligomers. The shape memory effect will be used to create a degradation or release of bioactive substances on demand, induce forces on seeded cells or... |
| Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial | 20080306014 | 20081211 |
| The present invention provides agents which are capable of regulating the function of a micro-RNA component which can be used to regulate an AChE-associated biological pathway. In addition, the present invention provides methods and pharmaceutical compositions for the treatment of various pathologies related to AChE-associated biological pathways such as apoptosis, aberrant cholinergic signaling, abnormal hematopoietic proliferation and/or differentiation, cellular stress, exposure to inflammatory response-inducing agents, and/or exposure to organophosphates or other AChE inhibitors.
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| Activation of the arabidopsis hypertall (hyt1/yucca6) locus affects several auxin mediated responses | 20080307542 | 20081211 |
| The present invention provides nucleotide sequences and a corresponding amino acid sequence of auxin overproduction mutants. Also provided are methods to improve plant growth, development, differentiation, increased tolerance to drought and delayed senescence as well as plants with drought tolerance and delayed senescence.
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| Clutch outer member for multi-plate clutch | 20080296119 | 20081204 |
| A clutch outer member (1) for a multi-plate clutch is provided that includes an end wall (7), a large number of fins (30) extending axially from the outer peripheral part of the end wall (7) and arranged at equal intervals in the peripheral direction so as to define spline grooves (20B) therebetween, and an annular connecting part (31) formed on the outer periphery at the extremity of this group of fins (30) and connecting the fins (30) integrally to each other, the fin (30) having an axially-extending weight-cutting bottomed groove (33) formed, wherein the annular connecting part (31) is provided, on a part of its outer end face corresponding to each of the spline grooves (20B), with a reference notch (32) indicating the position of the... |
| Disc device | 20080298211 | 20081204 |
| A disc device includes a lens that focuses a laser light on an optical disc surface, a focus drive unit that drives the lens in a focusing direction, a focus control unit that controls to focus the laser light on the optical disc surface, a focus displacement detecting unit that detects a displaced amount in the focusing direction, a differentiation unit that differentiates a focus displacement detected signal, and a unit that inverts a sign of a differentiated signal, thereby, the disc device is driven intermittently to restrain a motion of an objective lens in a focusing direction and avoid colliding the objective lens with the optical disc surface.
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| Microsplitter module for optical connectivity | 20080298743 | 20081204 |
| A compact optical splitter module is disclosed. One type of compact optical splitter module is a planar attenuated splitter module that includes a branching waveguide network having j≧1 50:50 splitters that form up to n≦2j output waveguides having associated n output ports, wherein only m<n output ports are suitable for transmitting light to the at least one external output device. This provides a 1×m splitter module wherein each output port has the attenuation of a 1×n splitter module, thereby obviating the need for external attenuation. Another type of compact optical splitter module is a direct-connect splitter module that eliminates the need for an optical fiber array when coupling to external optical fibers. Another type of compact optical splitter module is a microsplitter module that serves as... |
| Direct-connect optical splitter module | 20080298748 | 20081204 |
| A compact optical splitter module is disclosed. One type of compact optical splitter module is a planar attenuated splitter module that includes a branching waveguide network having j≧1 50:50 splitters that form up to n≦2j output waveguides having associated n output ports, wherein only m<n output ports are suitable for transmitting light to the at least one external output device. This provides a 1×m splitter module wherein each output port has the attenuation of a 1×n splitter module, thereby obviating the need for external attenuation. Another type of compact optical splitter module is a direct-connect splitter module that eliminates the need for an optical fiber array when coupling to external optical fibers. Another type of compact optical splitter module is a microsplitter module that serves as... |
| Cultured muscle cells with high metabolic activity and method for production of the cultured muscle cells | 20080299086 | 20081204 |
| The object of the present invention is to provide a method of preparing excellent cultured muscle cells having high metabolic capacity and insulin responsiveness, and further provide a method for the measurement of sensitive metabolic capacity using the cells. Moreover, its purpose is to provide a culture system/culture apparatus that can smoothly translocate such highly advanced cultured muscle cells intact to activity evaluation systems of a number of drugs. Moreover, the object of the present invention is to provide cultured muscle cells that are very suitable for measurement of the membrane-translocation activity of GLUT4 in an extraneous stimulus-dependent manner such as insulin, etc., and to provide a method for the measurement of the membrane-translocation activity of GLUT4 using the cells. The present invention is a method... |
| Endogeneous repair factor production promoters | 20080299089 | 20081204 |
| It relates to an endogenous repair factor production accelerator which comprises one or at least two selected from prostaglandin (PG) 12 agonist, EP2 agonist and EP4 agonist. Since prostaglandin (PG) 12 agonist, EP2 agonist or EP4 agonist has various endogenous repair factor production accelerating action, angiogenesis acceleration action and stem cell differentiation induction action, it is useful as preventive and/or therapeutic agents for ischemic organ diseases (e.g., arteriosclerosis obliterans, Buerger disease, Raynaud disease, myocardial infarction, angina pectoris, diabetic neuropathy, spinal canal stenosis, cerebrovascular accidents, cerebral infarction, pulmonary hypertension, bone fracture, Alzheimer disease, etc.) and various cell and organ diseases.
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| Topographical templating of polymeric materials using cellular morphology | 20080299169 | 20081204 |
| Substrates for influencing the organization, spreading or adhesion of a selected cell to induce or stimulate growth, differentiation or regeneration of the cell or of tissue constituting the cells are provided as well as methods of making such substrates and methods of using such substrates.
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| Culture system for rapid expansion of human embryonic stem cells | 20080299582 | 20081204 |
| This disclosure provides an improved system for culturing human pluripotent stem cells. Traditionally, pluripotent stem cells are cultured on a layer of feeder cells (such as mouse embryonic fibroblasts) to prevent them from differentiating. In the system described here, the role of feeder cells is replaced by components added to the culture environment that support rapid proliferation without differentiation. Effective features are a suitable support structure for the cells, and an effective medium that can be added fresh to the culture without being preconditioned by another cell type. Culturing human embryonic stem cells in fresh medium according to this invention causes the cells to expand surprisingly rapidly, while retaining the ability to differentiate into cells representing all three embryonic germ layers. This new culture system allows... |
| Solid ink stick with enhanced differentiation | 20070296781 | 20071227 |
| An ink stick for use in a phase change ink imaging device is provided. The ink stick comprises a three dimensional ink stick body having an exterior surface. Two or more interface tracks are formed in the exterior surface of the ink stick parallel to a feed direction of an ink loader. Each interface track includes one or more actuation portions for actuating one or more sensors in the feed channel. The ink mass of the ink stick body may be substantially the same between actuation portions of a first interface track. A second interface track includes at lease one predetermined characteristic corresponding to a distance between an actuation portion of the second interface track and another feature of the ink stick, the predetermined characteristic being... |
| Classification and verification of static file transfer protocols | 20070297417 | 20071227 |
| Classification and verification of static file transfer protocols is provided. A network node sitting in the path of packets classifies traffic according to its content, and then statistically verifies that the content actually matches the initial classification. Classification and verification are standard building blocks in networks systems that provide quality-of-service. However, unlike traditional quality-of-service building blocks, a system of the present invention takes a trust-but-verify approach, and thus can rely on longer-timescale statistical online or offline verification to reduce computational requirements. This improves scalability and reduces the cost and complexity that in part has prevented prior service differentiation systems from succeeding in the Internet. Internet Service Providers (ISPs) can combine the classification and verification building blocks with a networked directory service to allow further classification as... |
| Methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hbs) | 20070298016 | 20071227 |
| The present invention relates to methods for obtaining endodermal progenitor cells and further differentiating these to hepatocyte-like cells. Knowledge about the cell composition prior to the initiation of terminal differentiation is used to select one of two different protocols and one of two type of intermediate progenitors depending on the purpose for which the resulting hepatocyte-like cells are needed. Protocol A of the present invention relates to differentiation of extraembryonic-resembling endodermal progenitor cells to hepatocyte-like cells and may be selected when yield and purity of the obtained hepatocyte-like cells is important. Protocol B of the present invention relates to differentiation of mesendodermal-resembling progenitor cells to hepatocyte-like cells and may be selected when quality of the obtained hepatocyte-like cells is important.
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| Stem cells | 20070298453 | 20071227 |
| A novel human embryonic stem cell line (hES-NCL1) is described together with a method for culturing a blastocyst and obtaining an embryonic stem cell line therefrom. Also described is the spontaneous partial differentiation of the embryonic stem cell line so obtained to produce fibroblast-like cells which act as an autogeneic feeder system to the stem cells. A novel fibroblast-like cell line hESC-NCL is described.
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| Method for transdifferentiating cells | 20070298495 | 20071227 |
| An object of the present invention is to provide a method for transdifferentiating a mature cell without using a DNA methylating agent or a DNA demethylating agent. The present invention provides a method for transdifferentiating a finally differentiated mature cell having a first differentiation phenotype into a finally differentiated mature cell having a second differentiation phenotype that differs from the above first differentiation phenotype by changing culture conditions for the finally differentiated mature cell having the first differentiation phenotype, wherein culture conditions suitable for culturing the finally differentiated mature cell having the above first differentiation phenotype are changed to culture conditions suitable for culturing the finally differentiated mature cell having the above second differentiation phenotype.
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| Enumeration method of analyte detection | 20070298513 | 20071227 |
| This invention is directed to an optically-based method and system for analyte detection using solid phase immobilization, specific analyte labels adapted for signal generation and corresponding processes for the utilization thereof. The enumeration detection method disclosed herein narrows the area for signal observation, thus, improving detectable signal to background ratio. The system is comprised of a platform/support for immobilizing a sample stage having a labeled sample (analyte complex) bound thereto, a radiation source, an optical apparatus for generating and directing radiation at said sample and a control that obtains data and then conducts analyses using digital image data. Upon engagement of the system, the sample generates a signal capable of differentiation from background signal, both of which are collected and imaged with a signal detector that... |
| Circuit design support method, device thereof, and circuit design support program | 20070300197 | 20071227 |
| To enable automatic calculation of a circuit element value and a waveform by a computer. In a circuit design support for calculating a circuit element value of an analog electronic circuit to be designed, by causing a computer to execute a program having a description of a repetition calculation equation of the Newton method including the Jacobi matrix, a program of the aforementioned calculation equation in which a partial differentiation as an element in the Jacobi matrix is replaced by an approximation equation is used. Furthermore, the element to be subjected to the partial differentiation in the Jacobi matrix is obtained from the waveform observed in response to the circuit configuration of the analog electronic circuit.
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| Electronic volume apparatus | 20070290758 | 20071220 |
| where g′(t) is time differentiation of g(t).
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| Method and system for content-based differentiation and sequencing as a mechanism of prioritization for qos | 20070291768 | 20071220 |
| Certain embodiments of the present invention provide a method for communicating data with message content over a network to provide Quality of Service. The method includes receiving data over a network, prioritizing the data, and communicating the data based at least in part on the priority. The step of prioritizing the data includes differentiating the data based at least in part on message content. Certain embodiments of the present invention provide a system for communicating data including a data prioritization component and a data communications component. The data prioritization component is adapted to prioritize data. The data prioritization component includes a differentiation component. The differentiation component is adapted to differentiate the data based at least in part on message content. The data communications component is adapted... |
| Method of generating islet beta-cells from exocrine pancreatic cells | 20070292388 | 20071220 |
| The present invention discloses an in vitro method wherein mammalian beta-cell differentiation can be induced in dedifferentiated exocrine pancreatic cells in a medium comprising ligands of the EGF receptor and the GP130 receptor, such as EGF and LIF. Insulin secreting cells, obtainable by this method, provide a means for the treatment of diabetes by islet transplantation.
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| Differentiation of multi-lineage progenitor cells to hepatocytes | 20070292398 | 20071220 |
| Fetal blood multi-lineage progenitor cells that are capable of a wide spectrum of transdifferentiation are described, as well as methods of differentiating the progenitor cells into mature hepatocytes.
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| Method of defining the differentiation grade of tumor | 20070292423 | 20071220 |
| The present invention relates to a method of defining the differentiation grade of tumor by selecting genes and/or proteins whose expression level correlates with each differentiation grade of tumor, measuring the expression of the genes and/or proteins of human tumor tissues in each differentiation grade. The present invention also relates to the use of these genes and/or proteins for diagnosing the differentiation grade of tumor and for screening anti-cancer agents for tumor treatment.
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| Serum-free media and their uses for chondrocyte expansion | 20070292949 | 20071220 |
| The present invention provides defined serum-free cell culture media useful in culturing fibroblasts, especially articular chondrocytes, that avoid problems inherent in the use of serum-containing media. The defined media comprise platelet-derived growth factor (PDGF), chemically defined lipids, oncostatin M (OSM), interleukin-6 (IL-6), leukemia inhibitory factor (LIF), or combinations of these compounds. In another aspect, the present invention also provides tissue culture methods that comprise incubating chondrocytes in the defined serum-free media. The methods enhance attachment and proliferative expansion of chondrocytes seeded at low density while maintaining their redifferentiation potential.
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| Methods for improving islet signaling in diabetes mellitus and for its prevention | 20070293426 | 20071220 |
| The present invention discloses methods for therapeutically treating mammals, including but not limited to humans, to increase the relative insulin producing performance of endogenous pancreatic β-cells, to cause differentiation of pancreatic epithelial cells into insulin producing β-cells, to improve muscle sensitivity to insulin and other weight control efforts by the chronic oral administration of a DP IV-inhibitor. The administration causes the active form of GLP-1 and other non-nutrient stimulated growth hormones to remain biologically active longer under physiological conditions. The extended presence of such hormones, in particular in the pancreatic tissue can also facilitate differentiation and regeneration of the β-cells already present that are in need of repair.
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| Agents, compositions and methods for treating pathologies in which regulating an ache-associated biological pathway is beneficial | 20070293452 | 20071220 |
| The present invention provides agents which are capable of regulating the function of a micro-RNA component which can be used to regulate an ACHE-associated biological pathway. In addition, the present invention provides methods and pharmaceutical compositions for the treatment of various pathologies related to AChE-associated biological pathways such as apoptosis, aberrant cholinergic signaling, abnormal hematopoietic proliferation and/or differentiation, cellular stress, exposure to inflammatory response-inducing agents, and/or exposure to organophosphates or other AChE inhibitors.
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| Combinatorial methods for inducing cancer cell death | 20070293453 | 20071220 |
| The present invention relates to methods and compositions for inhibiting proliferation and inducing cell death in a population of cancer cells by (i) increasing the amount of the differentiation associated protein MDA-7, and (ii) decreasing RAS activity within the population. It is based, at least in part, on the discovery that decreasing expression of a mutated, activated K-ras gene, together with introducing an expressible mda-7 gene, in pancreatic cells had a synergistic growth-inhibitory and anti-survival effect, and abolished tumorigenicity of the cells in athymic nude mice. The methods of the invention may be directed to the therapy of pancreatic cancer and other malignancies.
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| Pyrazole kinase modulators and methods of use | 20070293507 | 20071220 |
| The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
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| Salts and polymorphs of a potent antidiabetic compound | 20070293536 | 20071220 |
| Salts and polymorphs of a compound useful in the treatment of inflammatory and metabolic conditions and diseases are provided herein. In particular, the invention provides salts and polymorphs of a compound which modulates the expression and/or function of a peroxisome proliferator-activated receptor. The salts and polymorphs are useful for the treatment or prevention of conditions and disorders associated with energy homeostasis such as type II diabetes, lipid metabolism, adipocyte differentiation and inflammation.
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| Usb keystroke monitoring apparatus and method | 20070294441 | 20071220 |
| An apparatus and method for monitoring USB keystroke data sent between a host (1) and keyboard (4) which allows the differentiation and monitoring between USB data sent at full speed (12 Mbps) and low speed (1.5 Mbps) on a USB data line (2). The differentiation is achieved by detecting when full speed USB data has been sent by detecting the single ended zero (SE0) condition of the previous packet and measuring the pulse width in the subsequent synchronisation sequence and detecting when low speed USB data has been sent by detecting the presence of a preamble packet or measuring the pulse width of the synchronisation sequence. Thus, the monitoring and differentiation between mixed said low speed and said full speed USB data is allowed which enables... |
| Photoperiodic control of floret differentiation and yield in plants | 20070294789 | 20071220 |
| A method for improving the yield of a plant is presented. The method uses genetic engineering techniques for transformation of plants to introduce expression cassettes for over- or under-expression of genes involved in photoperiodic control of floret differentiation and degradation. Such methods provide for increased yield at harvest when compared to wild-type plants.
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| Packet classification method for networks with static routing | 20070286186 | 20071213 |
| Packet classification and routing in a data communication network with static routing procedure, wherein the routing is performed without using a routing table. First values for each common address bit of end service points adjacent to a switch as a response to a local subnet mask of the switch are defined. Then the packet flows from the current switch to the adjacent switches are forwarded in response to a value of differentiation bits. Unprocessed packets are forwarded to the main adjacent switch according to the main adjacent switch definition. Unforwarded are processed packets locally as exceptions.
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| Mixing techniques for mixing audio | 20070286426 | 20071213 |
| This disclosure describes audio mixing techniques that intelligently combine two or more audio signals into an output signal. The techniques allow audio to be combined, yet create perceptual differentiation between the different audio signals. The result is that a user is able to hear both audio signals in a combined output, but the different audio signals do not perceptually interfere with one another. The techniques are relatively simple to implement and are well suited for radio telephones.
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| Decision construct for configuring a networked computing environment | 20070288415 | 20071213 |
| A decision construct provides a system and method of configuring/managing/controlling a networked computing environment, such as a learning technology/platform. The construct provides one or more permission levels associated with one or more users of the system, such as independent permission levels for a provost, a dean, a department chair, a course director, and a faculty member, wherein the permission levels allow differentiation amongst the users of the system as to various decisions that are made to configure the networked computing environment. The decisions are made by the user through interaction with decision cells that the user(s) is allowed access to based on their associated permission level. The access and decisions that the user is allowed to make affect various component features, such as the display and... |
| Method for checking the friction capability of an exhaust gas catalytic converter | 20070277503 | 20071206 |
| In a process for monitoring the function capability of an exhaust-gas catalytic converter 5 located in the exhaust line 3 of an internal combustion engine 1, based on the measured or computed signals of a first lambda probe 6a located upstream from the catalytic converter 5 and of a second lambda probe 6b located downstream from the catalytic converter 5, the two lambda probes 6a, 6b and the catalytic converter 5 having reached their operating temperature, it is suggested that an air quantity control means 4 located in the intake line 2 is partially opened during the coasting phase of the internal combustion engine 1 in order to cool the catalytic converter 5 located in the exhaust line 3, so that in the catalytic converter 5... |
| Pharmaceutical preparations for and treatment of ocular surface and other disorders | 20070280924 | 20071206 |
| A pharmaceutical preparation suitable for use in the eye, which comprises: (i) a pharmaceutically acceptable carrier suitable for use in the eye; (ii) one or more ingredients selected from factors and agents that promote any one or more of survival, health, cell attachment and normal differentiation of ocular surface epithelial cells and optionally factors and agents to prevent squamous metaplasia; (iii) one or more agents capable of altering the fluid properties of a tear film including at least one agent capable of establishing and/or maintaining a stable tear film and optionally one or more agents selected from opthalmological lubricating agents, viscosity enhancing agents and agents capable of reducing tear film evaporation; the factors and agents in component (ii) and (iii) being synthetic or recombinant or licensed... |
| Compositions and methods for stem cell expansion and differentiation | 20070280989 | 20071206 |
| The present invention relates to compositions comprising stem cells and partially committed progenitor cells and to methods of controlling cell proliferation and differentiation, which can be used for expansion of stem cells and their subsequent differentiation. The present invention provides expanded population of essentially undifferentiated stem cells, which are useful in clinical procedures involving stem cell therapy, and a population derived thereof of which at least part of the cells are differentiated. The cells can be used per se, as a part of a cell-bearing composition comprising cross-linked hyaluronic acid-laminin gels or as a part of a composite implant for tissue regeneration.
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| Use of monoclonal antibodies to distinguish protein conformational isoforms | 20070281318 | 20071206 |
| Methods of preparing monoclonal antibodies that differentially bind to a single conformer of a protein of interest are described. Passive immunization using these antibodies as well as use of conformer-specific antibodies as diagnostic reagents for the purpose of stratification of patient populations with regards to disease outcome, drug efficacy or drug sensitivity is also disclosed as well as active immunization with the protein conformer. In the screening techniques, detection can be for example by tissue immunostaining, western blotting or solution IP. A specific mab termed 7VC which shows conformation specificity to CtmPrP, a prion protein conformer that triggers neurodegeneration under specific assay conditions of pH and copper concentration, is described. A second specific antibody termed 19B10 shows conformation specificity for NtmPrP, a prion protein conformer that... |
| Methods for inducing the differentiation of blood monocytes into functional dendritic cells | 20070281354 | 20071206 |
| Methods are provided for inducing differentiation of blood monocytes into functional antigen presenting dendritic cells. The blood monocytes are treated by exposing the monocytes to proteins adhered to the surface of a treatment device to induce differentiation of the monocytes in to dendritic cells. Differentiation of the monocytes may also be induced by physical perturbation of the monocytes during treatment. The treated monocytes may be co-incubated with disease effector agents, which may be phagocytized by the immature dendritic cells.
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| Compositions and methods for self-renewal and differentiation in human embryonic stem cells | 20070281355 | 20071206 |
| The present invention provides compositions and methods for the production of differentiated mammalian cells. More particularly, the present invention provides cellular differentiation methods employing culturing the cells on a feeder layer or under feeder-free conditions in cell culture and further contacting the cells with an inhibitor of the PI3-kinase pathway for the generation of differentiated mammalian cells from pluripotent mammalian stem cells. Preferably, the differentiated cell is selected from the group consisting of a mesendodermal cell, a mesodermal cell, and an endodermal cell.
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| Postnatal stem cells and uses thereof | 20070274958 | 20071129 |
| The invention generally relates to postnatal dental stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal dental pulp stem cells, use of the cells to generate dentin, and differentiation of the cells. In another aspect, the invention relates to human postnatal deciduous dental pulp multipotent stem cells, use of the cells to generate dentin, and differentiation of the cells.
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| Position measuring arrangement and method for controlling scanning signals of the position measuring arrangement | 20060288598 | 20061228 |
| A method for controlling a scanning signal of a light-electric position measuring arrangement, the method includes in a first mode of operation providing the scanning signal to a control device and the control device comparing an amplitude of the scanning signal with a predetermined level and makes a differentiation as to whether the amplitude lies above or below the predetermined level. In a second mode of operation the method includes reducing the amplitude of the scanning signal by attenuating light within a light beam path, and the reduced amplitude is compared with the predetermined level and generating an indication which is suitable for controlling a basic setting of a scanning head relative to a scale.
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| Control device for servo die cushion | 20060288755 | 20061228 |
| A control device of a die cushion mechanism, by which a force between a slide and a die cushion may follow a commanded value even in the rapid acceleration or deceleration of the slide and, moreover, a problem such as vibration of the mechanism may be prevented in the gradual acceleration or deceleration of the slide. The control device includes a slide position detecting part, such as a position sensor, for detecting the position of the slide and a correcting part for correcting a current commanded value using an acceleration of the slide, obtained by second-order differentiation of the position of the slide detected by the position sensor.
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| Beta cell growth and differentiation | 20060292127 | 20061228 |
| The invention includes methods that can be used to increase β cell populations in vivo and in vitro, useful in the treatment of diabetes and related disorders.
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| Method and nucleic acids for the analysis of breast cell proliferative disorders | 20060292564 | 20061228 |
| The present invention relates to modified and genomic sequences, to oligonucleotides and/or PNA-oligomers for detecting the cytosine methylation state of genomic DNA, as well as to a method for ascertaining genetic and/or epigenetic parameters of genes for use in the differentiation, diagnosis, treatment and/or monitoring of breast cell proliferative disorders, or the predisposition to breast cell proliferative disorders.
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| Dna diagnostic screening for turner syndrome and sex chromosome disorders | 20060292602 | 20061228 |
| The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of Turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the X and Y chromosomes.
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| Methods of gene expression monitoring | 20060292614 | 20061228 |
| The invention provides methods of monitoring expression of a plurality of genes in a cell or small population of cells. Preferred methods entail contacting an array of probes with a population of nucleic acids derived from a population of fewer than 1000 cells then determining the relative hybridization of the probes to the population of nucleic acid as a measure of the relative representation of genes from the cells. The invention further provides methods of classifying cells. These preferred methods entail determining an expression profile of each of a plurality of cells then classifying the cells in clusters determined by similarity of expression profile. The invention further provides methods of monitoring differentiation of a cell lineage. These preferred methods entail determining an expression profile of each... |
| 2-propylidene-19-nor-vitamin d compounds | 20060293291 | 20061228 |
| 2-propylidene-19-nor-vitamin D compounds are disclosed as well as pharmaceutical uses for these compounds and methods of synthesizing these compounds. These compounds are characterized by high bone calcium mobilization activity and high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment and prophylaxis of diseases where bone formation is desired, particularly osteoporosis, as well as autoimmune diseases such as multiple sclerosis, diabetes mellitus and lupus. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis. These compounds also increase both breaking strength and crushing strength of bones evidencing use in conjunction with bone replacement surgery such... |
| Tie-2 modulators and methods of use | 20060293342 | 20061228 |
| The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
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| Methods for modulating osteochondral development using bioelectrical stimulation | 20060293724 | 20061228 |
| Compositions and methods are provided for modulating the growth, development and repair of bone, cartilage or other connective tissue. Devices and stimulus waveforms are provided to differentially modulate the behavior of osteoblasts, chondrocytes and other connective tissue cells to promote proliferation, differentiation, matrix formation or mineralization for in vitro or in vivo applications. Continuous-mode and pulse-burst-mode stimulation of cells with charge-balanced signals may be used. Bone, cartilage and other connective tissue growth is stimulated in part by nitric oxide release through electrical stimulation and may be modulated through co-administration of NO donors and NO synthase inhibitors. Bone, cartilage and other connective tissue growth is stimulated in part by release of BMP-2 and BMP-7 in response to electrical stimulation to promote differentiation of cells. The methods and... |
| Novel haemopoietin receptor and genetic sequences encoding same | 20060294608 | 20061228 |
| The present invention relates generally to a novel haemopoietin receptor or derivatives thereof and to genetic sequences encoding same. Interaction between the novel receptor of the present invention and a cytokine ligand facilitates proliferation, differentiation and survival of a wide variety of cells. The novel receptor and its derivatives and the genetic sequences encoding same of the present invention are useful in the development of a wide range of agonists, antagonists, therapeutics and diagnostic reagents based on ligand interaction with its receptor.
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| Vehicle passenger detection apparatus with wireless acquisition of passenger-related data | 20060283651 | 20061221 |
| A vehicle passenger detection apparatus includes passive RF seat force sensors at each seating location and a single-point electronic control unit (ECU) for wirelessly acquiring passenger-related data from each of the sensors. A sensor-loaded surface acoustic wave (SAW) device is installed in each seating location of the vehicle, and the ECU successively interrogates the SAW devices to determine passenger presence for each of the seating locations. The SAW devices have distinguishable fundamental resonance frequencies for differentiation among the seating locations. A fluid-filled elastomeric bladder is installed in the seat bottom of each seating location, and a pelletized sensor including a capacitive pressure sensor and a SAW device is disposed in each bladder. The pressure sensor capacitively loads the respective SAW device so that when interrogated by... |
| Decorative portable filing bag | 20060283743 | 20061221 |
| A decorative portable filing bag having reinforced layers of coordinating interior and exterior fabrics precisely fitted over a hanging file frame and coordinated removable hanging files with a fabric handle. This novel filing system provides significant differentiation from current briefcases and cardboard portable systems both in utility and style.
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| Programmable sample rate analog to digital converter and method for use therewith | 20060284749 | 20061221 |
| A programmable sample rate ADC includes a delta sigma modulator for producing a digital signal, and a programmable decimation filter, that includes X stages of integration, a down-sampling stage for down-sampling by a factor of N, and Y stages of differentiation. The programmable sample rate ADC produces a digital output signal at a substantially constant frequency.
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| Targeting pulmonary epithelium using adrp | 20060286033 | 20061221 |
| This invention provides novel compositions and methods for the specific and/or preferential delivery of an effector (e.g. a drug or label) to an epithelial cell (e.g. a pulmonary epithelium). The compositions comprise an adipocyte differentiation-related protein (ADRP) attached to an effector thereby forming a chimeric moiety. The chimeric moiety is preferentially delivered to epithelial cells.
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| Conditioned cell culture medium, method to obtain the same and use of it for maintenance, proliferation and differentiation of mammalian cells | 20060286081 | 20061221 |
| The invention relates to a conditioned cell culture medium and a corresponding method to obtain it. The invention also refers to methods of using this cellconditioned medium for the maintenance, proliferation and differentiation of mammalian cells. The culture medium produced in accordance with the present invention is conditioned by the cell secretion activity of murine cells, in particular, those differentiated and immortalized transgenic hepatocytes, named MMH (Met Murine Hepatocyte). These media are employed in in vitro cell culture systems to induce maintenance, proliferation and differentiation of mammalian cells. The cells named MMH are differentiated non transformed murine hepatocytes that produce important biological molecules (e.g cytokines and growth factors) and, in accordance with the present invention, they are used in in vitro cell culture systems for the... |
| Agent for promoting osteogenesis and/or inhibiting bone resorption | 20060286084 | 20061221 |
| Provided is a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which: can be directly taken from daily meals by mouth for long periods without any trouble in taste; directly impart a promoting effect on osteogenesis and an inhibiting effect on bone resorption to the bone; and can be expected to have therapeutic effects for preventing or ameliorating/treating various bone diseases. The above agent includes, as an active ingredient, any one or more of β2-microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, and β defensin, and enzymatic digestion products thereof. Those substances have a remarkable inhibiting effect on bone resorption by osteoclasts and/or a promoting effect on osteogenesis via promotion of the... |
| Lymphoid chemokines in the diagnosis, monitoring and treatment of inflammatory disease | 20060286556 | 20061221 |
| Experimental autoimmune encephalomyelitis (EAE) is a Th1-mediated autoimmune disease of the central nervous system that is widely used as an animal model of multiple sclerosis (MS). In this study it was demonstrate that CXCL13, a chemokine involved in the development of secondary lymphoid tissues, is expressed in CD11c+ myeloid cells that accumulate in EAE lesions. Blockade or deficiency of CXCL13 ameliorates clinical EAE, both during acute and relapsing stages. CXCL13 deficiency did not inhibit the priming or differentiation of autoimmune effector T-cells in the periphery, but appeared to exert its effects during the effector phase of pathogenesis. These findings indicate that reagents that antagonize or inhibit CXCL13 are useful for the treatment of neuroinflammatory diseases such as MS.
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| Methods and nucleic acids for the analyses of cellular proliferative disorders | 20060286576 | 20061221 |
| The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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| Methods and apparatuses for culturing stem cell using biomaterial shell | 20060286666 | 20061221 |
| Disclosed are methods and apparatuses for culturing stem cell using biomaterial shell, e.g. fertilized zebrafish chorions, which may induce formation of embryonic bodies, cell proliferation, and cell differentiation to other types effectively inside the chorions without adding any inducing agents or cell differentiation stimulants. There is provided an apparatus for culturing stem cell using biomaterial shell comprising: a microwell layer having a plurality of microwells; a microhole layer having a plurality of microholes, the microhole layer being located under the microwell layer, diameter of the microholes being smaller than diameter of the microwells and diameter of the biomaterial shell; and a flow-channel layer having a plurality of flow-channels for supplying cell medium to the microholes, the flow-channel layer being located under the microhole layer, and wherein... |
| Small organic molecule regulators of cell proliferation | 20060287385 | 20061221 |
| The present invention makes available methods and reagents for modulating proliferation or differentiation in a cell or tissue comprising contacting the cell with a hedgehog agonist, such as the compounds depicted in FIGS. 32 and 33. In certain embodiments, the methods and reagents may be employed to correct or inhibit an aberrant or unwanted growth state, e.g., by antagonizing a normal ptc pathway or agonizing smoothened or hedgehog activity.
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| Monitoring two dimensions of diabetes pathogenesis seperately or concurrently (insulin sensitivity and beta-cell sufficiency): uses in diagnosis, prognosis, assessment of disease risk, and drug development | 20060280682 | 20061214 |
| Provided are methods for determining concurrently with a simple, minimally invasive test, the adequacy of pancreatic beta-cell compensation and/or the presence of tissue insulin resistance in a subject human or an experimental animal. The methods allow for the determination of a subject's or experimental animal's susceptibility to developing type 2 diabetes mellitus (DM2) or to progression to more advanced forms of DM2. Among other uses, the methods allow for diagnostic classification of subjects for decisions regarding therapeutic interventions, clinical differentiation between type 1 DM and DM2, clinical monitoring of treatments intended to reduce risk of developing DM2 in non-diabetic subjects, clinical monitoring of agents intended to improve existing DM2 and to prevent progression of DM2, clinical development and testing of new compounds, candidate agents, or candidate... |
| Effect of porcine sheath proteins on the regeneration activity of periodontal ligament | 20060280699 | 20061214 |
| The purpose of this study was to identify the periodontal regeneration factors in enamel protein shown to induce cementum- and osteo-promotive activities in vivo. The cementum regeneration (CR), a part of periodontal regeneration, was examined by using experimental cavities prepared in a buccal dehiscence dog model. The CR activity was found in the aggregate consisted of sheath proteins along with a small amount of amelogenins separated from newly formed secretory enamel. The sheath proteins were purified to be homogeneous, and examined for the alkaline phosphatase (ALP) inducing activity of human periodontal ligament (HPDL) cells. Application of 17 kDa sheath protein induced ALP activity in HPDL cells. Peptides synthesized from the sheath protein sequence also showed ALP inducing activity. The 17 kDa sheath protein has cell differentiation... |
| Preparation of endodermal stem cells | 20060281136 | 20061214 |
| It is intended to prepare endodermal stem cells by differentiation from multipotential stem cells followed by isolation. This object can be achieved by separating various endodermal stem cells having been differentiated from multipotential stem cells with the use of, as indications, a specific cell surface marker, an organizer-specific marker and the expression manner of E-cadherin.
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| Inducer for differentiation of embryo stem cells into ectodermal cells method of obtaining the same and use thereof | 20060281179 | 20061214 |
| A method for obtaining a solution having activity to induce differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell, which comprises culturing a stromal cell in a culture comprising a polyanionic compound and recovering the culture; a solution having activity to induce differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell, which is obtainable by the method; and an agent for inducing differentiation of an embryonic stem cell into an ectodermal cell or ectoderm-derived cell.
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| S100 protein as neutrophil activator for alleviating neutropenia in cancer treatment | 20060281674 | 20061214 |
| The present invention relates to a method and composition for inducing lymphocyte proliferation and migration, and for reducing the risks of microbial infections in patients immuno-supressed. The present invention particularly relates to the use of S100 protein, such as MRP, to induce the proliferation, differentiation and release of immune cells from bone marrow. More particularly, S100A8, S100A9, S100A12 and S100A8/A9 are administered to patients with lowered neutrophil blood concentrations.
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| Methods of increasing proliferation of adult mammalian cardiomyocytes through p38 map kinase inhibition | 20060281791 | 20061214 |
| Compositions and methods for increasing proliferation and/or de-differentiation of postmitotic mammalian cardiomyocytes are disclosed to slow, reduce, or prevent the onset of cardiac damage. In addition, the methods and compositions of the invention can used to produce de-differentiated cardiomyocytes, which can then be used in tissue grafting, implantation or transplantation. The invention is based, in part, on the discovery that postmitotic mammalian cardiomyocytes can proliferate as a result of targeted disruption of p38 MAP kinase. p38 inhibition with optional growth factor stimulation can induce cytokinesis in adult cardiomyocytes.
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| Treatment and inhibition of disease conditions using flexible heteroarotinoids | 20060281806 | 20061214 |
| The present invention contemplates methods of treating, reducing, inhibiting or preventing several diseases by the administration of flexible heteroarotinoids. Among the diseases or conditions which can benefit from treatment with flexible heteroarotinoids as described herein are, (1) cancers and other diseases that involve abnormal differentiation, (2) diabetes, (3) hemophelia, (4) liver disease, (5) diseases involving human aldehyde dehydrogenase 2, (6) polycystic kidney disease, (7) lysosomal storage diseases, (8) high cholesterol, (9) obesity, (10) high triglycerides, (11) glycoprotein metabolism diseases, and (12) diseases involving abnormal angiogenesis.
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| Combined effects of nutrients on proliferation of stem cells | 20060275512 | 20061207 |
| A method and composition for stimulating the proliferation and differentiation of stem cells is used to self-repair injury in mammals. A supplement is administered having an effective dose of blueberry, carnosine, catechin, green tea extract, VitaBlue, Vitamin D3 or combinations of these. For example, a therapeutic amount of two or more of the supplements may be selected having a synergistic effect, allowing a lower dose to achieve the same or greater effective protection as a higher dose of any one of the supplements.
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| Modified human embryonic stem cells and methods of use to treat neuron-associated disorders | 20060275744 | 20061207 |
| The invention is directed to methods for promoting the differentiation and maturation of embryonic and adult stem cells to dopamine neurons by increasing expression of the transcription factors Nurr1 and PitX3 in the stem cells. The invention provides embryonic and adult stem cells expressing Nurr1 and PitX3 from nucleic acid vectors, and dopamine neurons differentiated therefrom, and methods for treating a neuron-associated disorder, such as Parkinson's Disease, using the cells of the invention. The invention encompasses screening assays using the cells of the invention to identify compounds capable of inducing differentiation of stem cells to dopamine neurons.
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| Compositions and methods for making embryonic stem cells | 20060275898 | 20061207 |
| The invention relates to cell proliferation, cell differentiation, male infertility, male fertility and to compositions and methods involved therein.
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