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Differentiation patents



      

This page is updated frequently with new Differentiation-related patent applications.




Date/App# patent app List of recent Differentiation-related patents
06/23/16
20160178600 
 Test strips for visual differentiation of liquid mixture composition patent thumbnailnew patent Test strips for visual differentiation of liquid mixture composition
A test strip device exhibits visual changes, such as color changes, when there is a only slight difference in the composition of liquids such as gasoline, oil, ethanol and water. Such a slight liquid composition difference usually requires a sophisticated and expensive instrument to differentiate.

06/23/16
20160177368 
 Selective enrichment medium for carbapenem-resistant bacteria patent thumbnailnew patent Selective enrichment medium for carbapenem-resistant bacteria
The present invention relates to a method for direct detection and differentiation of carbapenem-resistant bacteria in a sample comprising (i) inoculation with said sample of a culture medium comprising at least meropenem and/or ertapenem and at least one chromogenic agent, (ii) incubation of said culture medium under conditions allowing the growth of carbapenem-resistant bacteria, and (iii) detection of colonies formed on said culture medium corresponding to a carbapenem-resistant bacteria, as well as a culture medium suitable for use in such a method.. .

06/23/16
20160177267 
 Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof patent thumbnailnew patent Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
Disclosed herein are methods for generating sc-β cells using chemically defined, completely serum free media, and isolated populations of sc-β cells for use in various applications, such as cell therapy.. .

06/23/16
20160176927 
 Peptide for suppressing osteoclast differentiation and use thereof patent thumbnailnew patent Peptide for suppressing osteoclast differentiation and use thereof
The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (il)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of nf-κb and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-b ligand (rankl)-rank signaling pathway, and suppresses the expression of a rankl or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (trap), cathepsin k, or tnf receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration.

06/23/16
20160175225 
 Peptides and their use in the treatment of skin patent thumbnailnew patent Peptides and their use in the treatment of skin
Embodiments of the invention are related generally to the methods of diminishing the signs of aging in and/or improving health of human integuments, such as skin, and compositions comprising peptides useful therefor. The compositions according to the invention may comprise one or more peptides or fragments or derivatives thereof derived from a growth factor, e.g., growth differentiation factor 11 (gdf11), in a topically acceptable vehicle..

06/16/16
20160170777 
 Modified jvm with multi-tenant application domains and class differentiation patent thumbnailModified jvm with multi-tenant application domains and class differentiation
A method and system for operating a modified java virtual machine (jvm) which is able to simultaneously host multiple java application programs is disclosed. In a first modification the jvm is modified to permit multiple class definitions of some of the java application programming interface (api) classes, so called non-sensitive classes, to be loaded multiple times but restrict other java api classes, so called sensitive classes, to be loaded only once, preferably onto a bootstrap class loader.
Waratek Limited


06/16/16
20160169911 
 Marker for statin treatment stratification in heart failure patent thumbnailMarker for statin treatment stratification in heart failure
The present invention is directed to a method of identifying a patient having heart failure as likely to respond to a therapy comprising a statin. The method is based on measuring the level of at least one marker selected from gdf-15 (growth differentiation factor 15), urea, shbg (sex hormone-binding globulin), uric acid, plgf (placental growth factor), il-6 (interleukin-6), transferrin, a cardiac troponin, sflt-1 (soluble fms-like tyrosine kinase-1), prealbumin, ferritin, osteopontin, sst2 (soluble st2), and hscrp (high sensitivity c-reactive protein) in a sample from a patient.
Roche Diagnostics Operations, Inc.


06/16/16
20160168535 
 Generation of anterior foregut endoderm from pluripotent cells patent thumbnailGeneration of anterior foregut endoderm from pluripotent cells
The invention is directed to in vitro methods of inducing differentiation of anterior foregut endoderm and the enriched populations of anterior foregut endoderm produced by such methods. Such enriched populations are useful for studies of the molecular events that occur during differentiation and for generating cells for cell replacement therapy..
Mount Sinai School Of Medicine


06/16/16
20160168213 
 Growth differentiation factor 15 (gdf-15) constructs patent thumbnailGrowth differentiation factor 15 (gdf-15) constructs
Constructs comprising gdf15, and mutants thereof are provided. In various embodiments the constructs comprising gdf15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder.
Amgen Inc.


06/16/16
20160168205 
 Methods and compositions for labeling polypeptides patent thumbnailMethods and compositions for labeling polypeptides
Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms.
President And Fellows Of Harvard College


06/16/16
20160166687 

Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate


The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent.
Irm Llc


06/16/16
20160166615 

Material for treatment of cerebral infarction


A material for treatment of cerebral infarction ameliorates angiopathy at a cerebral infarction region and improves brain function. The material for treatment of cerebral infarction according to the present invention comprises a dental pulp stem cell including at least one of a cd105-positive cell, an sp cell, a cd24-positive cell, a cd271-positive cell, and a cd150-positive cell.
National Center For Geriatrics And Gerontology


06/09/16
20160163227 

Methods and devices for intraoral tactile feedback


The present invention is directed to methods and devices for teaching the proper configuration of the oral articulators, particularly the tongue, corresponding to particular speech sounds by providing intraoral tactile feedback. Intraoral tactile feedback is achieved by placing nodes in the oral cavity of the patient in locations corresponding to the proper lingual position required to produce a target sound.
Articulate Technologies, Inc.


06/09/16
20160161464 

Stem cell differentiation determination device, method, and program


A stem cell differentiation determination device includes an observation image acquisition unit that captures an image of an observation region including a stem cell in time series to acquire at least two observation images, a feature amount acquisition unit that acquires at least one feature amount of the stem cell for each observation image, a determination unit that determines whether or not the stem cell has been differentiated, on the basis of the feature amount, a change information acquisition unit that acquires information about a change in the feature amount between the observation images captured in time series or information about a change in a determination result from undifferentiation to differentiation between the observation images, and an output unit that outputs the information about a change in the feature amount or the information about a change in the determination result.. .
Fujifilm Corporation


06/09/16
20160160219 

Composition containing ppar-gamma neddylation inhibitor for inhibiting adipocyte differentiation and use thereof


Provided is a method for suppressing an adipose differentiation comprising administering to a subject in need thereof a ppar-v neddylation inhibitor for inhibiting adipocyte differentiation and a method for screening an adipocyte differentiation inhibitor using ppar-v neddylation associated with adipocyte differentiation. The inhibitor of a neddylation pathway of ppar-v inhibits the differentiation from mesenchymal stem cells to mast cells, and thus can be effectively used to treat obesity, and particularly, can be also useful in the treatment of severe obesity which cannot be excepted to be treated by existing obesity treatment agents..
Seoul National University R&db Foundation


06/09/16
20160160184 

Methods for reprogramming cells and uses thereof


Described herein are reprogrammed cells, and methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also descried are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming.
Novagenesis Foundation


06/09/16
20160160182 

Differentiation of human pluripotent stem cells


The present invention provides a method for increasing the expression of mafa in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of mafa.. .
Janssen Biotech, Inc.


06/09/16
20160160177 

Method and medium for neural differentiation of pluripotent cells


The invention relates to a culture medium comprising an inhibitor of the bmp signaling pathway; and an inhibitor of the tgf/activin/nodal signaling pathway and to a method for obtaining a population of neural precursors using said culture medium.. .
Association Francaise Contre Les Myopathies


06/09/16
20160158163 

Method for treating gefitinib-resistant non-small-cell lung cancer


The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (nsclc) comprising administering an effective amount of a resveratrol analogue, (z)3,4,5,4′-tetramethoxystilbene (tms), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant nsclc cells comprising contacting the resveratrol analogue to the cells at an effective amount.
Macau University Of Science And Technology


06/09/16
20160158152 

Pharmaceutical composition for the treatment of diminution of bone tissue


A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from withaferin a (wfa), withanolide a, and withanone. The composition showed enhanced wfa bioavailability in rodents against plain wfa, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (bv/tv%) by 3 folds as compared to free withaferin a (wfa)..
Council Of Scientific & Industrial Research


06/09/16
20160157470 

Non-human animals having a humanized cluster of differentiation 47 gene


Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an endogenous cluster of differentiation (cd) gene, in particular a humanization of a cd47 gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous cd47 gene so that said non-human animals express a cd47 polypeptide that includes a human portion and a non-human portion (e.g., a murine portion)..
Regeneron Pharmaceuticals, Inc.


06/09/16
20160157469 

Non-human animals having a humanized cluster of differentiation 274 gene


Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a cluster of differentiation 274 (cd274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous cd274 gene so that said non-human animals express a programmed cell death ligand 1 (pd-l1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion)..
Regeneron Pharmaceuticals, Inc.


06/02/16
20160153871 

Cytoplasmic stain composition


Disclosed is a composition of cytoplasm stain for use in differentiation of cell nuclei from cell cytoplasmic components and differentiation of specific cytoplasm components by tinctorial contrast. Specifically, the invention relates to stain composition utilized as a counter stain in the hematoxylin and eosin procedure for use in histological and cytological microscopic evaluation of tissue and cells.

06/02/16
20160152950 

Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors


Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors..
Wisconsin Alumni Research Foundation


06/02/16
20160152677 

Single domain tdf-related compounds and analogs thereof


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
Thrasos Innovation, Inc.


06/02/16
20160152674 

Tdf-related compounds and analogs thereof


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
Thrasos Innovation, Inc.


06/02/16
20160151717 

Reconfigurable plush toy


Improvements in a reconfigurable plush toy that is filled with material that allows the toy to be crushed, and washed without harm to the user. The plush toy can be used by infants to young children that can reconfigure the reconfigurable plush toy from known to imaginable toys.

06/02/16
20160150767 

Mirna-regulated differentiation-dependent self-deleting cassette


Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell.
Regeneron Pharmaceuticals, Inc.


05/26/16
20160150152 

Photographing method and apparatus


A digital camera is provided with a frequency component extraction unit, an ar evaluation value acquisition unit, a variation calculation unit, and a moving speed control unit. The frequency component extraction unit has first and second filters, and extracts first and second spatial frequency components.
Fujifilm Corporation


05/26/16
20160146447 

Heat-dissipating socket for lighting fixtures


An led lighting assembly, including a socket member operable to electrically communicate with a solid-state lighting element, at least two electrical connections extending into the socket member for electrically communicating with a solid-state lighting element, at least two electrical receivers extending into the socket member and capable of electrical communication with the at least two electrical connections, a differentiation groove embedded in the socket member, a driver element in electrical communication with the at least one socket member, and a heat-dissipating member operationally connected to the socket member. Other implementations include securing and energizing the solid-state lighting element by inserting the solid-state lighting element into the socket member and twisting; polarity-specific electrical connections using uniquely sized electric receivers and/or electrical connectors; and active and/or passive heat dissipation..

05/26/16
20160145641 

Stepwise differentiation of stem cells for the production of eukaryotic membrane proteins


A method useful for making a eukaryotic membrane protein in vitro may be carried out by (a) propagating in vitro vertebrate stem cells; (b) transforming the vertebrate stem cells in vitro with a heterologous expression vector containing a nucleic acid encoding the eukaryotic membrane protein; and then (c) differentiating the stem cells in vitro into differentiated cells (or photoreceptor-like cells) that express the membrane protein.. .
Uab Research Foundation


05/26/16
20160145578 

Method for differentiation of pluripotent stem cells into multi-competent renal precursors


This application relates to a method for differentiating pluripotent stem cells (pscs) into multi-competent renal precursor cells expressing six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes.
Hoffmann-la Roche Inc.


05/26/16
20160145574 

Kit and promoting mesenchymal stem cell differentiation


The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor..
National Taiwan University


05/26/16
20160145350 

Antibodies against cd73 and uses thereof


The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human cluster of differentiation 73 (cd73) with high affinity, and inhibit the activity of cd73, and optionally mediate antibody dependent cd73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided.
Bristol-myers Squibb Company


05/26/16
20160145250 

Anti-cancer compounds


Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit skp2 are provided.
Board Of Regents, The University Of Texas System


05/26/16
20160144075 

Bone matrix compositions and methods


Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity.
Warsaw Orthopedic, Inc.


05/26/16
20160143940 

Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems


Psa is delivered to the host by outer membrane vesicles (omvs), secretion structures that target bacterial molecules to host cells. Purified omvs direct the in vitro differentiation of functional tregs with potent suppressive activity in a psa dependent manner.
California Institute Of Technology


05/26/16
20160143939 

Compositions, kits and methods for treatment of cardiovascular,immunological and inflammatory diseases


Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature and precursor sequences of micrornas 142-5p, 142-3p, 17-5p, 17-3p, 374, and 20a, and of antisense molecules complementary to these sequences, to manipulate processes relevant to, for example, the cardiac response to stress, including survival signaling, angiogenesis, stem cell differentiation along muscle or vascular lineages, and repression or promotion of cardiac myocyte growth. Also described are methods to treat cardiovascular, immunological and inflammatory diseases by engineering cells containing specific micro-rnas or antagomirs against specific mrnas.
University Of Miami


05/26/16
20160143877 

Composition for suppressing adipocyte differentiation, for reducing fat accumulation and/or for promoting adiponectin secretion and usage for said composition


The present invention relates to a composition for suppressing adipocyte differentiation, for reducing fat accumulation in adipocytes and/or for promoting adiponectin secretion from adipocytes, including sesaminol as an active component. The present invention also relates to a method for suppressing adipocyte differentiation, for reducing fat accumulation in adipocytes and/or for promoting adiponectin secretion of adipocytes, including administering a composition including sesaminol as an active component..
Kiyomoto Iron & Machinery Works Co Ltd


05/19/16
20160140303 

Value-based health care management systems and methods


A system and method are disclosed for management of patient care and research using a combination of value-based methodology and translational research methodology. The system includes software to generate a single outcome measurement, or “value-quotient (vq)” expressing a delivered health value and the associated costs.
The Regents Of The University Of California


05/19/16
20160138094 

Direct, programmable detection of epigenetic dna cytosine modifications using tal effectors


The present invention relates to methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest o,r (ii) said unmodified cytosine residue of interest, said methods making use of the capability of transcription-activator-like effector (tale) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of tale proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest or (ii) said unmodified cytosine residue of interest..
UniversitÄt Konstanz


05/19/16
20160138024 

Screening compound having obesity preventive or therapeutic activity


A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action.

05/19/16
20160138017 

Microrna and uses in brown fat differentiation


This invention reveals a novel mirna and a novel mirna-regulated signaling network which controls brown adipogenesis and thermogenic programs, thereby providing a powerful approach for the treatment of obesity and related metabolic diseases. In this regard, the present invention is also directed towards methods of treatment of obesity and excess weight (overweight) and metabolic disorders caused by or aggravated by a subject being overweight or obese..
Joslin Diabetes Center, Inc.


05/19/16
20160137982 

P38 mapk inhibitor-containing medium and osteogenic differentiation


Here is provided a novel differentiation protocol, which was experimentally shown to give rise to osteoprogenitor cells in vitro. A novel medium composition containing a p38 mapk inhibitor was found to promote differentiation of human adipose stem cells (hascs) to osteoprogenitor cells.
Tampereen Yliopisto


05/19/16
20160137981 

Induced pluripotent stem cell selection method and inducing differentiation to blood cells


A method for producing hematopoietic stem cells and/or hematopoietic progenitor cells from pluripotent stem cells is described. The method includes a step of culturing pluripotent stem cells in the presence of igf2.
Kyoto University


05/19/16
20160137975 

Generation of male germ cells


Methods are provided for the generation of male germ cells from somatic cells. Included are methods of non-integrative reprogramming for germ cell differentiation with a reduced risk of neoplasia during in vivo differentiation by the inclusion of vasa with the reprogramming factors.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


05/19/16
20160137707 

Synaptogenic protein tagged with biotin and reconstitution of artificial synapse by using same


Disclosed is a polypeptide containing an extracellular domain of a synaptogenic protein, and a method for manufacturing a nerve cell, a complex containing a biotin tagged at the c-terminus of the polypeptide, an artificial synapse inducer for coupling the composite to a streptavidin (sav)-coated substrate and a nerve cell. The complex tagged with a biotin at the c-terminus of the polypeptide containing the extracellular domain of the synaptogenic protein, such as neuroligin-1, can display activity by being attached to the sav-coated substrate to adjust the orientation thereof without help of a supported lipid bilayer.
Seoul National University R&db Foundation


05/19/16
20160136310 

Systems, compositions, and methods for local imaging and treatment of pain


Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission.
The Regents Of The University Of California


05/12/16
20160130559 

Cell populations, methods of transdifferentiation and methods of use thereof


The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes..
Tel Hashomer-medical Research, Infrastructure And Services Ltd.


05/12/16
20160130556 

Enhanced differentiation of mesenchymal stem cells


Isolated populations of mesenchymal stem cells (mscs) are provided, including mammalian mesenchymal stem cells (mscs) characterized by the lack of cd54 (cd54−) or low cell-surface cd54 (cd54low). Methods of in vitro cell differentiation and methods of treatment using said isolated populations are also provided..
Escape Therapeutics, Inc.


05/12/16
20160130554 

Reprogramming mesenchymal stromal cells into hematopoietic cells


Method for reprogramming of stromal cells into hematopoietic cells are provided. Also provided are mesenchymal stromal cells that can be reprogrammed into hematopoietic cells.
Wake Forest University Health Sciences


05/05/16
20160123985 

Hematopoietic cell phenotyping using circulating cell-free markers


The present invention provides methods of classifying cluster of differentiation (cd) marker phenotype for hematopoietic cancer cells using multiple circulating cell-free cd markers in bodily fluid. In other aspects, treatment and disease progression of particular hematopoietic cancers can be monitored by measuring the levels of cd and other markers in bodily fluids of a patient..
Quest Diagnostics Investments Incorporated


05/05/16
20160123979 

Biomarkers for early diagnosis and differentiation of mycobacterial infection


Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.. .
Wisconsin Alumni Research Foundation


05/05/16
20160122826 

Use of id4 for diagnosis and treatment of cancer


Methods for diagnosis and treatment of cancer using id4 are disclosed. Specifically, epigenetic inactivation of id4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis.
John Wayne Cancer Institute


05/05/16
20160122803 

Early developmental genomic assay for characterizing pluripotent stem cell utility and safety


The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use.
President And Fellows Of Harvard College


05/05/16
20160122721 

Use of rna for reprogramming somatic cells


The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing rna encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate..
Johannes Gutenberg Universitat Mainz


05/05/16
20160122720 

Method of efficiently establishing induced pluripotent stem cells


The invention provides a method of producing ips cells, which comprises the steps of (i) introducing reprogramming factors into somatic cells; (ii) culturing the cells obtained in step (i) for more than 11 days and not more than 29 days; (iii) sorting tra-1-60-positive cells from the cells obtained in step (ii); (iv) culturing the tra-1-60-positive cells sorted in step (iii); (v) transferring a colony obtained in step (iv) to another culture vessel; and (vi) culturing the cells obtained in step (v), thereby obtaining ips cells. The cells obtained in step (v) are preferably subcultured 10 times or more.
Kyoto University


05/05/16
20160122719 

Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof


The present invention discloses novel compositions and methods for enhancing cardiac differentiation efficiency of stem cells or promoting ventricular and atrial cardiomyocytes formation from stem cells. The present invention also discloses the atrial and ventricular cardiomyocytes formed from the stem cells, and the uses of the cardiomyocytes for repairing cardiac injuries and screening for new medicaments for treating cardiac injuries..
Institute Of Biophysics, Chinese Academy Of Sciences


05/05/16
20160122717 

Differentiation of pluripotent stem cells and cardiac progenitor cells into striated cardiomyocyte fibers using laminins ln-511, ln-521 and ln-221


The present disclosure describes methods of differentiating cardiomyocyte progenitor cells and mature cardiomyocyte cells from pluripotent stem cells. The methods may include differentiating pluripotent stems cells on a substrate including (i) laminin-511 or 521 and (ii) laminin 221.
Biolamina Ab


05/05/16
20160122711 

Chemical differentiation of pluripotentstem cells into retinal epithelial cells


The present invention is based in part on a chemically defined method of generating retinal epithelial cells and retinal pigmented epithelial cells from human pluripotent stem cells (hpscs). The present invention also provides methods and kits for treating degenerative eye disorders..
International Stem Cell Corporation


05/05/16
20160122702 

Method for determining cell state and autoanalyzer using said method


There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (ile, val, ser, leu, and ala), thereby making a determination..
Hitachi High-technologies Corporation


05/05/16
20160122402 

Retro polypeptides for activation immunity to cancer and viral infection


A polypeptide that drives t cell proliferation and differentiation, and methods and agents for modulating the expression and/or function of the polypeptide. Agents that up regulate the expression and/or function of the polypeptide are useful in the treatment or prevention of diseases and disorders that would benefit from stimulation of t cell proliferation and/or differentiation, such as cancer and chronic viral infections.
Imperial Innovations Limited


05/05/16
20160120945 

Thymic regeneration


Methods for regenerating thymic tissues, e.g., for the treatment of subjects who have thymic insufficiency, i.e., whose thymic tissues are absent or atrophied due to illness, age, or injury, by administration of growth differentiation factor 11 (gdf11).. .
Joslin Diabetes Center


04/28/16
20160119177 

Semi-polar modulator


A modulation processor (500) comprises a first processing stage (110) and a second processing stage (120). The first processing stage (110) comprises a phase generation stage (117) arranged to generate a phase signal (pm) indicative of a phase of a modulation signal (s), a differentiation stage (118) arranged to generate a frequency signal (fm) by differentiating the phase signal (pm), and a first bandwidth reduction stage (113) arranged to generate a first output signal (fm_lp) by reducing a bandwidth of the frequency signal (fm).
Telefonaktiebolaget L M Ericsson (publ)


04/28/16
20160115555 

Biomarkers for differentiating melanoma from benign nevus in the skin


Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (phactr1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (spp1), preferentially expressed antigen in melanoma (prame), growth differentiation factor 15 (gdf15), and chemokine c-x-c motif ligand 10 (cxcl10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of phactr1, or fragments thereof, either alone or in combination with the detection of spp1, prame, gdf15, and cxcl10, for the diagnosis or prognosis of melanoma..
Advanced Cell Diagnostics


04/28/16
20160115519 

Cell differentiation devices and methods


Methods, devices, and kits are provided for identifying, selecting, and/or manipulating live cells in a sample comprising a suspected mixed population of cells by subjecting the sample located in a first position to a linear gradient of a cellular stimulus to induce a change in a live cell sufficient to induce movement of the cell from a first position to a second position, wherein a dead cell, if present in the sample, is not induced to move to the second position in the presence of the cellular stimulus; and identifying or selecting the live cell in the second position.. .
Georgia Tech Research Corporation


04/28/16
20160115453 

Differentiation and expansion of endothelial cells from pluripotent stem cells and the in vitro formation of vasculature like structures


The disclosure is concerned among others with means and methods for obtaining endothelial cells and to means and methods for in vitro cell culture comprising endothelial cells and pericytes and/or smooth muscle cells derived from the pericytes. The endothelial cells or the pericytes and/or smooth muscle cells, or both, are preferably derived from in vitro differentiated pluripotent stem cells..
Academisch Ziekenhuis Leiden


04/28/16
20160115449 

Novel producing differentiated cells


The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage.
The University Of Tokyo


04/28/16
20160115448 

Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells


Provided are cortical interneurons and other neuronal cells and in vitro methods for producing such cortical interneurons and other neuronal cells by the directed differentiation of stem cells and neuronal progenitor cells. The present disclosure relates to novel methods of in vitro differentiation of stem cells and neural progenitor cells to produce several type neuronal cells and their precursor cells, including cortical interneurons, hypothalamic neurons and pre-optic cholinergic neurons.
Cornell University


04/28/16
20160115447 

Compositions and methods for improving induced neuron generation


The present inventions relate to methods and compositions useful for improving the efficiency of inducing the generation of neurons from non-neuronal cell types, for example, by contacting the cell or cell culture medium with one or more agents which inhibit activin and/or plk1 signaling. Also disclosed are methods for promoting neuron survival, for example, by inhibiting activin and/or plk1 signaling, and methods for promoting the survival of intermediates in a cell differentiation pathway, for example, by inhibiting activin and/or plk1 signaling..
President And Fellows Of Harvard College


04/28/16
20160115446 

Technologies, methods, and products of small molecule directed tissue and organ regeneration from human pluripotent stem cells


Pluripotent human embryonic stem cells (hescs) hold great potential for restoring tissue and organ function, which has been hindered by inefficiency and instability of generating desired cell types through multi-lineage differentiation. This instant invention is based on the discovery that pluripotent hescs maintained under defined culture conditions can be uniformly converted into a specific lineage by small molecule induction.
San Diego Regenerative Medicine Institute


04/28/16
20160115238 

Cd20 antibodies and uses thereof


Cd20 is a transmembrane protein of the tetra-spanin family expressed on the surface of b-cells from peripheral blood as well as lymphoid tissues. Cd20 expression persists from the early pre-b cell stage until the plasma cell differentiation stage.
Immunogen, Inc.


04/28/16
20160115167 

Bmp inhibitors and methods of use thereof


The present invention provides small molecule inhibitors of bmp signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
The General Hospital Corporation


04/28/16
20160113979 

Pharmaceutical composition for promoting bone tissue formation, containing stauntonia hexaphylla leaf extract as active ingredient


The present invention relates to a composition for promoting osteoblast or cartilage cell differentiation. More particularly, the present invention relates to a composition, which includes stauntonia hexaphylla leaf extract that may be safely used without toxicity and side effects by using a natural ingredient, for promoting bone (tissue) formation to be used for suppressing and treating bone and cartilage tissue damage.
Jeonnam Bioindustry Foundation


04/21/16
20160112071 

Multiband wireless data transmission between aircraft and ground systems based on availability of the ground systems


Provided are methods and systems for multiband wireless data transmission between aircraft and ground systems. The transmission uses different wavelength ranges, each wavelength range corresponding to a different data domain and establishing a different communication channel.

04/21/16
20160108366 

Method for inducing exocrine pancreatic cells


An object of the present invention is to provide a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells. The above object is achieved by providing a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells using a culture solution containing a histone deacetylase inhibitor and/or a ligand protein for a notch signal, and a protein kinase c activator..

04/21/16
20160108362 

Culture medium and inducing differentiation of pluripotent stem cells into neuroepithelial cells


The present invention discloses a culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells. The culture medium comprises at least two agents for neural induction, wherein the agents includes a wnt signal agonist and a smad2/3 inhibitor and the culture medium is a feeder free culture.

04/21/16
20160108126 

Cd20 antibodies and uses thereof


Cd20 is a transmembrane protein of the tetra-spanin family expressed on the surface of b-cells from peripheral blood as well as lymphoid tissues. Cd20 expression persists from the early pre-b cell stage until the plasma cell differentiation stage.

04/21/16
20160108118 

Anti-tnf-alpha/cxcl10 double-targeting antibody and use thereof


The present invention relates to a tnf-α (tumor necrosis factor-alpha)/cxcl-10 (c-x-c motif chemokine 10) double targeting antibody based on the igg format. Specifically, it was verified that an antibody, in which scfv having a heavy chain variable domain and a light chain variable domain of the cxcl10 specific antibody links to the c-terminus of the heavy chain constant domain of the tnf-α specific antibody, is a bispecific antibody that effectively binds to both tnf-α and cxcl10, and thus the antibody can be useful as a double targeting antibody capable of identifying tnf-α/cxcl10.



Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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