|| List of recent Differentiation-related patents
|Certain chemical entities, compositions, and methods|
Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described. Specifically quinoxaline derivatives of formula i and their use in modulating the activity of braf and/or mutant braf kinase to regulate and modulate abnormal or inappropriate cell proliferation, differentiation, or metabolism are disclosed.
|Methods to modulate acute myeloid leukemia stem/progenitor cell expansion and/or differentiation|
Screening assays to identify compounds that may be useful for inhibiting and/or eliminating aml initiating cells using ahr modulators and/or the compounds of formula i or ii are also disclosed. The use of pharmaceutically acceptable agonists of the ahr for preventing or inhibiting minimal residual disease (mrd) in an aml patient is also disclosed..
|Islet cells from human embryonic stem cells|
This disclosure provides a system for producing pancreatic islet cells from embryonic stem cells. Differentiation is initiated towards endoderm cells, and focused using reagents that promote emergence of islet precursors and mature insulin-secreting cells.
|Method for treatment of damaged site of bone|
Provided is a treatment method which enables regeneration of bone tissue even when the size of a damaged site of bone is large. The treatment method comprises the steps of: culturing chondrocytes which have been seeded onto a porous body, or differentiating stem cells having chondrogenic differentiation potential which have been seeded onto a porous body into chondrocytes and culturing the chondrocytes; and implanting the porous body having the cultured chondrocytes..
|Neuron generation, regeneration and protection|
The invention demonstrates that, contrary to apoptotic rabies virus g proteins, certain non-apoptotic rabies virus g proteins, such as the g protein of the cvs-niv strain, have a neurite outgrowth promoting effect. The invention further demonstrates that this neurite outgrowth promoting effect is due to the cytoplasmic tail of said non-apoptotic rabies virus g proteins, more particularly to their pdz-bs, which shows a single-point mutation compared to the one of apoptotic rabies virus g proteins.
|Determining petrophysical properties using sodium nuclear magnetic resonance (nmr) logs|
The presence of hydrocarbons in a subsurface formation fluid may be inferred from a determined salt concentration. A sodium nuclear magnetic resonance (nmr) measurement of a subsurface formation is obtained and a salt concentration of the fluid in the subsurface formation is determined from the sodium nmr measurement.
|Loudspeaker noise inspection method, loudspeaker noise inspection device and recording medium for recording a loudspeaker noise inspection program|
A loudspeaker noise inspection method is to be implemented by an electronic device and includes the steps of: obtaining a frequency sweeping audio signal from an audio output generated by a loudspeaker in response to a frequency sweeping input signal; performing differentiation upon the frequency sweeping audio signal so as to generate a differentiated frequency sweeping audio signal; and dividing the differentiated frequency sweeping audio signal by a constant which is greater than 2π times a maximum frequency of the frequency sweeping audio signal, so as to obtain an attenuated frequency sweeping audio signal for inspection of a noise pulse in the frequency sweeping audio signal.. .
|Differentiation of traffic flows mapped to the same bearer|
In accordance with an example embodiment of the present invention, an apparatus comprising: at least one processor; and at least one memory including computer program code, wherein the at least one memory and the computer program code are configured to, with the at least one processor, cause the apparatus to perform at least the following: receive at least one traffic flow; establish at least one bearer for communication; assign a first quality of service class identifier value associated with the at least one bearer; map the at least one traffic flow to the at least one bearer; and determine a second quality of service class identifier value for a data packet of the at least one traffic flow.. .
|Differentiation of traffic flows for uplink transmission|
In accordance with an example embodiment of the present invention, an apparatus comprising: at least one processor; and at least one memory including computer program code, wherein the at least one memory and the computer program code are configured to, with the at least one processor, cause the apparatus to perform at least the following: receive at least one traffic flow; receive at least one quality of service indication associated with the at least one traffic flow; create binding of the received at least one quality of service indication and information associated with the received at least one traffic flow; and assign a quality of service indication to a data packet for transmission based at least in part on the created binding.. .
|Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use|
This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
|Modular emulsion-based product differentiation|
A micro-scale heterogeneous emulsion is provided. In some examples, the micro-scale heterogeneous emulsion can include at least two internal phases and an external phase.
|Compositions and methods for modulating myeloid derived suppressor cells|
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (mdsc). In particular, described herein are mir-142 polynucleotides and mir-223 polynucleotides that can be used to modulate differentiation of mdscs.
|Composition for preventing or treating obesity comprising rebamipide|
The present disclosure relates to a composition and a health functional food for preventing or treating obesity comprising a rebamipide compound or its pharmaceutically acceptable salt as an active component. It is confirmed that when a rebamipide compound of the present disclosure is administered to a mouse model induced with obesity, it shows excellent effects of reducing weight, reducing adipocyte, and reducing a total cholesterol content in the body, as compared with a non-administered control group, and also, it shows an excellent effect of suppressing differentiation of cytotoxic th17 cells that generate and secrets inflammatory cytokine and an excellent effect of improving activity of regulatory t cells (treg) capable of suppressing a function of abnormally activated immune cells and controlling an inflammatory reaction.
|Method for preparing improved cardiomycocyte-like cells|
The present invention relates to the field of cell differentiation. In particular, the present invention relates to a method for preparing improved cardiomyocyte-like cells differentiated from at least one multipotent or pluripotent cell, comprising a step of contacting the cardiomyocyte-like cell(s) with at least one agent to promote and/or induce integrin subunit alpha-v (integrin αv) activity, thereby modulating expression of at least one cardiac gene of said cardiomyocyte-like cells.
|Methods of using mechanical force with somatic and pluripotent cells|
Provided are methods useful in increasing efficiency of biotransport, reprogramming or altering a cell's state of differentiation, and maintenance of cells in an undifferentiated state.. .
|Methods for promoting cell reprogramming|
The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency.
|Stem cell-derived neural cells for cell therapy in neurological disorders|
The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided..
|Modular emulsion-based product differentiation|
A micro-scale heterogeneous emulsion is provided. In some examples, the micro-scale heterogeneous emulsion can include at least two internal phases and an external phase.
|System and method for auditory captchas|
Disclosed herein are systems, methods, and computer readable-media for performing an audible human verification. The method includes determining that a human verification is needed, presenting an audible challenge to a user which exploits a known issue with automatic speech recognition processes, receiving a response to the audible challenge, and verifying that a human provided the response.
|Identifying abnormal tissue in images of computed tomography|
An imaging method for identifying abnormal tissue in the lung is provided, comprising the recording of slice images of the lung by means of x-ray radiation, recording of blood vessels, differentiation of blood vessels and abnormal tissue, segmentation of the abnormal tissue and display of the segmented abnormal tissue on an output device. In addition, a computer tomograph for identifying abnormal tissue in the lung is provided, having a radiation source for recording slice images of the lung and blood vessels by means of x-ray radiation, a computer unit for differentiating the blood vessels from the abnormal tissue and for segmenting the abnormal tissue, as well as an output device for displaying the segmented abnormal tissue.
|Noninvasive diagnosis of fetal aneuploidy by sequencing|
Disclosed is a method to achieve digital quantification of dna (i.e., counting differences between identical sequences) using direct shotgun sequencing followed by mapping to the chromosome of origin and enumeration of fragments per chromosome. The preferred method uses massively parallel sequencing, which can produce tens of millions of short sequence tags in a single run and enabling a sampling that can be statistically evaluated.
|Three-dimensional nanostructured hybrid scaffold and manufacture thereof|
A method of making a three-dimensional biocompatible scaffold capable of supporting cell activities such as growth and differentiation, the method includes providing a supporting grid that forms an open network and provides mechanical support of a second biocompatible material. The second biocompatible material has interconnected cavities that allow nutrients, metabolites and soluble factors to diffuse throughout the scaffold.
|Method of differentiating glioblastoma cells|
A method of increasing differentiation of a cell line of glioblastoma cells is disclosed. A platelet-rich plasma (prp) composition is prepared.
|Methods and compositions for culturing endoderm progenitor cells in suspension|
Provided herein are methods for the in vitro differentiation of induced pluripotent stem cells, which have been expanded and/or maintained under defined conditions, into endodermal precursor cells (epcs) that are capable of producing mono-hormonal beta cells.. .
|Tissue repair with multipotent cells|
The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in a human or animal patient using the concept of said method for inducing differentiation of multipotent cells.
|Single domain tdf-related compounds and analogs thereof|
The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
|Making and using in vitro-synthesized ssrna for introducing into mammalian cells to induce a biological or biochemical effect|
The present invention relates to compositions, kits and methods for making and using rna compositions comprising in vitro-synthesized ssrna inducing a biological or biochemical effect in a mammalian cell or organism into which the rna composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell.
|Methods of inducing chondrogenesis in mesenchymal stem cells using synthetic triterpenoids|
The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies).
|Distance sensing by iq domain differentiation of time of flight (tof) measurements|
A system and method for identifying a position of a moving object, regardless of static objects present in the optical field of an active infrared (ir) proximity detector, is provided. Moreover, a modulated light emitting diode (led) signal is captured and processed through i/q demodulation.
|Integrated service identity for different types of information exchange services|
A service provisioning method includes providing a differentiated set of information exchange services to a user. In some embodiments, differentiation between or among the provided services may include differentiated access networks, differentiated physical network layers, and/or differentiated service providers.
|Method for de-differentiating a cell|
The invention relates to a method for de-differentiating a cell, i.e. The induction of a pluripotent phenotype.
|Medium composition for rejuvenating stem cells|
The present invention relates to a medium composition for transforming stem cells from an aged person into young stem cells, and more particularly to a medium composition for culturing stem cells, which is used to rejuvenate stem cells from an aged person so as to have characteristics similar to those of the stem cells of young people, and to a method for rejuvenating stem cells, which comprises culturing stem cells from an aged person in the medium composition. According to the present invention, even mesenchymal stem cells collected from over 60 years old patients can be transformed into young mesenchymal stem cells having high differentiation ability, high telomerase activity, and high ability to express stem cell markers.
|Populations of hematopoietic progenitors and methods of enriching stem cells therefor|
There is described herein a method of enriching a population of stem cells for hematopoietic progenitors. The method comprises inducing hematopoietic differentiation in a population of human embryonic stem cells or human induced pluripotent stem cells; sorting the population based on expression of cd43 and at least one of cd34, cd31 and cd144; and selecting a fraction that is at least one of cd34+cd43−, cd31+cd43− and cd144+cd43−.
|Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof|
The invention relates to a unique formulated pharmaceutical composition and a novel treatment method of intratumoral injection. The pharmaceutical composition of the invention is the saturated ionic solution of sodium ions and calcium ions (the “medicinal ion bomb”).
|Methods of generating glial and neuronal cells and use of same for the treatment of medical conditions of the cns|
A method of generating neural and glial cells is provided. The method comprising growing human stem cells under conditions which induce differentiation of said human stem cells into the neural and glial cells, said conditions comprising the presence of retinoic acid and an agent capable of down-regulating bone morphogenic protein activity..
|Finfet drive strength modification|
One application of this approach is to enable differentiation of the drive strengths of transistors in an integrated circuit by applying the technique to some, but not all, of the transistors in the integrated circuit. In particular in a sram cell formed from finfet transistors the application of the technique to the pass-gate transistors, which leads to a reduction of the drive strength of the pass-gate transistors relative to the drive strength of the pull-up and pull-down transistors, results in improved sram cell performance..
|Controller for textile heating device|
A controller for use in textile heating devices, such as heating pads, heating blankets, and the like is provided. The controller provides a display system for conveying to a user the selected heat setting.
|Detection apparatus for determining a state of tissue|
The invention relates to a detection apparatus (30) for determining a state of tissue. The detection apparatus (30) comprises a fluorescence spectrum providing unit (2, 3) for providing a fluorescence spectrum of the tissue, a differentiation unit (4) for generating a derivative of the fluorescence spectrum, and a tissue state determination unit (5) for determining the state of the tissue from the derivative.
|Compositions and methods for reprogramming eukaryotic cells|
The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mrna encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mrna that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mrna was introduced, and compositions therefor. For example, the present invention provides mrna molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells..
|Composition comprising a glucocorticoid and a thiazolidinedione for inducing compelte adipogenic differentiation of mammalian stem cells|
The present invention relates to the provision of a composition comprising a glucocorticoid and a thiazolidinedione for inducing adipogenic differentiation, thereby successfully generating functional stem cells, from non-differentiated embryonic or adult stem cells originating from humans or other mammals, special preference being given to human mesenchymal stem cells. The preferred glucocorticoid is dexamethasone and the preferred thiazolidinedione is rosiglitazone.
|Methods and compositions for diagnosis and prognosis of renal injury and renal failure|
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of stanniocalcin-1, antithrombin-iii, toll-like receptor 2, triiodothyronine (t3), thyroxine (t4), extracellular matrix protein 1, coagulation factor xiii a chain, coagulation factor xiii b chain, interleukin-17f, interleukin-22, vitronectin, progesterone, estradiol, growth/differentiation factor 15, and proprotein convertase subtilisin/kexin type 9 as diagnostic and prognostic biomarkers in renal injuries..
|Cell culture substrate comprising a laminin and a cadherin|
The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells.
|Method for producing corneal endothelial cell|
The invention provides a method of efficiently producing corneal endothelial cells, particularly from corneal stroma or ips cell-derived neural crest stem cells, a method of producing corneal endothelial cells stably in a large amount by inducing more efficient differentiation of stem cells into corneal endothelial cells, and a medicament containing corneal endothelial cells. The method of inducing differentiation of stem cells into corneal endothelial cells includes a step of culturing the stem cells in a differentiation induction medium containing a gsk3 inhibitor (preferably a gsk3β inhibitor) and retinoic acid, with the differentiation induction medium preferably further containing one or more of tgfb2, insulin, a rock inhibitor, and the like..
|Dna diagnostic screening for turner syndrome and sex chromosome disorders|
The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the x and y chromosomes.. .
|Femto cell access point passthrough model|
Fixed, differentiated quality of service (qos) is supplied for packetized traffic (e.g., voice and data) intended for femto cell coverage when transmitted concurrently with external broadband traffic. Quality of service differentiation is supplied without an external implementation.
|Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals|
Wherein a, y, z, r3 to r6, r20 to r22 and r50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (edg-2, edg2), which is activated by lysophosphatidic acid (lpa) and is also termed as lpa1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example.
|Method for screening induced pluripotent stem cells|
The present invention provides a method for screening for ips cells exhibiting differentiation resistance using a marker identified as lincrna or mrna that is specifically expressed in an ips cell line exhibiting differentiation resistance, and such markers.. .
|Encoded nanopore sensor for multiplex nucleic acids detection|
The present invention provides a new and improved multiplexed oligonucleotide detection method based on the nanopore technology with one or more probes containing a sequence with complementarity to the target oligonucleotide, a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini and a label attached to the terminus. The improved probes and probe sets enable sensitive, selective, and direct multiplex detection, differentiation and quantification of distinct target oligonucleotides such as mirnas.
|Method and use of metabolites for the diagnosis and differentiation of neonatal encephalopathy|
Metabolites and signatures (panels) of metabolites are applicable as biomarkers in clinical diagnosis, in particular for neonatal encephalopathy. They are useful tools in differential clinical diagnosis for early detection of brain injury, determination of brain areas affected by the insults and prediction of adverse neurological outcome and may also be applied in diagnosing disease progression and treatment effect.
|Multi-surface scattered radiation differentiation|
An optical inspector includes a radiating source, a time varying beam reflector, a telecentric scan lens, a first and second waveplate, a polarizing beam splitter, a first detector, a focusing lens, a blocker, and a second detector. The radiating source irradiates the first waveplate generating circularly polarized source beam that irradiates a first position of on the time varying beam reflector with a source beam.
|Ex vivo culture, proliferation and expansion of primary tissue organoids|
Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue.
|Bone matrix compositions and methods|
Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity.
|Compositions and methods for dental tissue regeneration|
Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing wnt3a and bmp-7, and optionally vegf, bfgf, or ngf, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and wnt3a and bmp-7, and optionally vegf, bfgf, or ngf..
|Compositions and methods for cancer and cancer stem cell detection and elimination|
In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded rna-specific adenosine deaminases, or adar, enzymes.
|Color x-ray histology for multi-stained biologic sample|
Systems and methods are provided for staining tissue with multiple biologically specific heavy metal stains and then performing x-ray imaging, either in projection or tomography modes, using either a plurality of illumination energies or an energy sensitive detection scheme. The resulting energy-weighted measurements can then be used to decompose the resulting images into quantitative images of the distribution of stains.
|Leveraging biometrics for authentication and touch differentiation|
Biometric authentication and touch differentiation embodiments are described which use a handheld mobile computing device having a signal injection site that injects a signal into a user's hand for a prescribed period of time, and at least one signal sensing site each of which captures a signal emanating from a finger of either of the user's hands that is touching the signal sensing site during at least the period of time the signal is injected. The captured signal or signals are analyzed to determine whether they match, to a prescribed degree, a pre-established signal model that is indicative of a signal or signals expected to be captured.
The present invention provides compounds, compositions and methods for treatment and/or prevention of neurodegenerative diseases, including but not limited to autoimmune diseases, such as multiple sclerosis, in which demyelination, (the loss of the myelin sheath that insulates the nerves) is an associated or causative feature. The data provided demonstrate the utility of the compounds and compositions according to this invention to promote oligodendrogenesis and myelination or remyelination..
|Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza a; influenza b; 2009 influenza a/h1n1; and a 2009 influenza a/h1n1 rna sequence mutation associated with oseltamivir resistance|
Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza a, influenza b, 2009 influenza a/h1n1, and a 2009 influenza a/h1n1 rna sequence mutation associated with oseltamivir resistance.. .
|Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells|
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering.
|Protein markers associated bone marrow stem cell differentiation into early progentior cells|
A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (bm) differentiation into dendritic cells (dc) during in vitro cultivation with the cytokine gm-csf by addition of antisera to an 82 kd bm cell surface protein generating cultivatable dendritic progenitor cells (dp). Genes, methods for preparing them as well as early dp have been provided.
|Method and device for carrying out a signal-processing viewing of a measurement signal that is correlated to the respiratory activity of an individual|
The invention relates to a method and device for carrying out a signal-processing viewing of a measurement signal that is correlated with the respiratory activity of an individual, for example, of a measurement signal that is correlated with the respiratory gas. The aim of the invention is to provide solutions with which an improved electronic analysis of the signals that are representative with regard to respiratory activity can be achieved.
|Bandwidth extension of audio signals|
Audio decoder and method therein for supporting bandwidth extension (bwe) of a received signal. The method involves receiving a first signal representing the lower frequency spectrum of a segment of an original audio signal; receiving a second signal, being a bwe signal, representing a higher frequency spectrum of the segment of the original audio signal.
|Inhibition of c-myc ubiquitination to prevent cancer initiation and progression|
The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of fbw7 e3 ligase inhibitors to inhibit c-myc ubiquitination in cancerous cell populations, such as leukemic initiating cell populations, that are responsible for disease initiation and progression..
|Methods of manipulating the fate of cells|
A method of manipulating the fate of a cell which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding rna species (cur), (b) a modified cur, or (c) a compound that modifies or affects cur, under condition sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of rna:rna or rna:dna or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained.