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Differentiation patents



      

This page is updated frequently with new Differentiation-related patent applications.




Date/App# patent app List of recent Differentiation-related patents
07/21/16
20160211127 
 Multiple oil-emission measuring device for engines patent thumbnailMultiple oil-emission measuring device for engines
A multiple oil-emission device for hydrocarbon emissions in an exhaust-gas mixture, comprising an exhaust-gas probe, which has a transfer capillary, and a measurement channel, which has an ion source and a filter apparatus having a measuring apparatus. The transfer capillary has a drop-catching apparatus at the tip of the transfer capillary, which drop-catching apparatus comprises a short throttle segment and a transfer segment, which adjoins the throttle segment in a flow direction and is at least ten times longer.
Lubrisense Gmbh


07/21/16
20160209856 
 Power restriction management system patent thumbnailPower restriction management system
A power restriction management system includes a network switching device with a preinstalled power restriction sequence value and a managing server. The network switching device is connected to a power source to acquire power and at least one electronic device to perform power restriction in the electronic device.
Luxul Technology Incorporation


07/21/16
20160208248 
 Neurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof patent thumbnailNeurocalcin delta inhibitors and therapeutic and non-therapeutic uses thereof
The present invention relates to an inhibitor of neurocalcin delta (ncald) for use in a method for the treatment or prevention of a patient suffering from a disorder associated with a pathological calcium homeostasis. Furthermore, the present invention refers to the use of such inhibitor of ncald for inducing axon proliferation in vitro and to a method for the differentiation and/or maturation of neuronal stem cells (nscs) in vitro and to the use of such inhibitor of ncald to restore impaired endocytosis being a consequence of disturbed ca2+ homeostasis in synaptic terminals essential for development, maturation and maintenance of synapses and neuromuscular junctions (nmjs)..
UniversitÄt Zu KÖln


07/21/16
20160208217 
 Method for enhancing therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases patent thumbnailMethod for enhancing therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases
A method for enhancing the therapeutic effect of stem cells on autoimmune diseases, cardiovascular diseases, and/or hematological diseases is provided. The method comprises pre-treating the stem cells with ligustilide to increase the expression of differentiation-promoting genes in the stem cells, increase the expression of homing-promoting genes in the stem cells, and/or decrease the expression of inflammatory genes in the stem cells, wherein the treatment is conducted in a culture medium of the stem cell..
Gwo Xi Stem Cell Applied Technology Co., Ltd.


07/21/16
20160208215 
 Generation of endocrine progenitor cells from human pluripotent stem cells using small molecules patent thumbnailGeneration of endocrine progenitor cells from human pluripotent stem cells using small molecules
The present invention relates to differentiation of stem cells into a homogeneous endocrine progenitor cell population suitable for further differentiation into pancreatic beta-cells. The present invention provides methods for obtaining ngn3/nkx2.2 double positive endocrine progenitor cells by exposing precursor cells to a tgf-β type i receptor inhibitor, a bmp antagonist, an adenylate cyclase activator and nicotinamide and/or exposing to the precursor cells to a selection of small molecules..
Takara Bio Europe Ab


07/21/16
20160207891 
 Malignant and non-malignant disease treatment with ras antagonists patent thumbnailMalignant and non-malignant disease treatment with ras antagonists
The present disclosure describes new inhibitors or antagonists of ras useful for the treatment of conditions resulting from ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition.
Pisces Therapeutics, Llc


07/21/16
20160207048 
 Method and system for producing gluten-free oats patent thumbnailMethod and system for producing gluten-free oats
A method and system for removing foreign grains from oat grains to establish gluten-free oats, i.e., oat grains having gluten levels below 20 ppm and, more preferably, below 10 ppm, relies upon performing various mechanical differentiation operations on a combination of grains, including oats and foreign, or gluten containing, grains. The mechanical differentiation operations can be arranged in series or in a combination of series and parallel operations.
General Mills, Inc.


07/21/16
20160206780 
 Matrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof patent thumbnailMatrix scaffold for three-dimensional cell cultivation, methods of construction thereof and uses thereof
This invention provides a matrix scaffold for three-dimensional (3d) cell cultivation, a method of its construction, and its uses. The matrix scaffold results from a crosslinking reaction of a fibroin-like substance prepared by a specific method from silk cocoons or filaments, chitosan and crosslinking agents.
Suzhou Cancercell Biotechnology Co. Ltd


07/21/16
20160206696 
 Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use patent thumbnailMethod of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use
This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
Advanced Neuroregenerative Therapies, Llc


07/14/16
20160202241 
 Nanofibrous photoclickable hydrogel microarrays patent thumbnailNanofibrous photoclickable hydrogel microarrays
Nanofibrous hydrogel microarray systems that act as facile, high throughput platforms for in vitro drug discovery and investigation and screening of combinatorial effects of physical and biochemical cues on maturation and differentiation of mammalian cells.. .
The Regents Of The University Of Colorado, A Body Corporate


07/14/16
20160202188 

Method of assessing hair colour changes


The invention provides a method of assessing the potential colour protecting effect in vivo of a test formulation such as rinse-off hair treatment formulation, the method comprising the steps of: providing a sample of the test formulation to be assessed; providing a model substrate in the form of a hair switch which has been artificially coloured; applying the test formulation to the hair switch; subsequently rinsing the test formulation from the hair switch; collecting the rinse liquor and analysing it for the presence of eluted colour; characterised in that the artificial colour used to colour the hair switch is a permanent hair colorant with a shade level 1 or 2 according to the international colour chart (i.c.c.). The method provides improved sensitivity and differentiation, and enables the tester to compare different technologies in terms of effectiveness..
Conopco, Inc., D/b/a Unilever


07/14/16
20160201055 

Methods, systems, and compositions relating to mirna-146a


Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microrna-146a, a promoter of microrna-146a expression, a microrna-146a mimic, thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, disease, or injury in mammals, including in human beings..
Henry Ford Health System


07/14/16
20160201035 

Methods for accelerated and enhanced cardiac differentiation of ips cells by electrical stimulation


Methods of generating cardiomyocytes from induced pluripotent stem cells (ipscs) are provided. More specifically, the present disclosure relates to methods of generating cardiomyocytes from ipscs using electrical stimulation.
University Of Cincinnati


07/14/16
20160201032 

Method of nociceptor differentiation of human embryonic stem cells and uses thereof


The present invention relates to the field of stem cell biology, in particular the linage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hesc), human induced pluripotent stem cells (hipsc), somatic stem cells, cancer stem cells, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hesc and/or hipsc to nociceptors (i.e.
Memorial Sloan Kettering Cancer Center


07/14/16
20160199538 

Collagen scaffold modified by covalent grafting of adhesion molecules, associated methods and use thereof for cardiovascular and thoracic cell therapy and contractile tissue engineering


Three-dimensional solid contractile collagen scaffolds having improved biological properties and electromechanical performance are provided. The scaffolds can be used for cell transplantation, including the fixation of biocompatible reagents and adhesion molecules which control cell adhesion, apoptosis, survival and/or differentiation simultaneously.

07/14/16
20160199530 

Bioresorbable wound dressing


The present invention is directed to novel non-woven fabrics containing growth and differentiation factor proteins. Said fabrics are specifically designed to accelerate tissue regeneration and wound healing processes of mammalian tissues.
Carl Freudenberg Kg


07/14/16
20160199381 

Inhibition of thymine dna glycosylase in the treatment of cancer


The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine dna glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine dna glycosylase in cancer cells.
Institut De Génétique Et De Biologie Moléculaire Et Cellulaire


07/07/16
20160196735 

Systems and methods for monitoring health in a shared living environment


The systems and method for monitoring health in a shared living environment may provide a collection of components and/or accessories that may, in various aspects, assist in deterring sexual coercion, sexual assault, and rape, provide a rapid response pathway in the event of sexual coercion or assault, stimulate and support event reporting by complainants, reduce false positive and false negative rates (for both accused and accusers), and/or enable later differentiation between meritorious and meretricious complainants and counter complainants (defendants/respondents) in future disciplinary or legal proceedings. In addition, other aspects of the systems and method described herein may assist in monitoring promoting other healthy lifestyle choices, such as sleep and study choices..

07/07/16
20160194607 

Cell culture medium for the growth and differentiation of cells of the hematopoietic lineage


A method for the production of cells of the hematopoietic lineage includes culturing hematopoietic stem cells (hsc) or embryonic bodies with a cell culture medium (the cell culture medium includes insulin at a concentration of from 1 to 50 μg/ml, transferrin at a concentration of from 100 μg/ml to 2000 μg/ml and plasma or serum at a concentration of from 1% to 30%) under conditions allowing producing cells of the hematopoietic lineage; and collecting cells of the hematopoietic lineage.. .
Assistance Publique - Hopitaux De Paris


07/07/16
20160194606 

Methods for inducing the differentiation of blood monocytes into functional dendritic cells


Methods are provided for treating blood monocytes to produce functional antigen presenting dendritic cells. An extracorporeal quantity of a subject's blood is treated to separate the blood and produce a leukocyte concentrate comprising monocytes and plasma containing proteins.
Yale University


07/07/16
20160194112 

Container and lid


A container lid (10) is provided herein having structurally reinforcing ribs (50) therein. The ribs (50) increase the strength of the lid across a central region thereof.
Kraft Foods Group Brands Llc


07/07/16
20160193035 

Apparatus for automated differential hair transplant


The present invention is useful to reduce the time and cost associated with the intervention, improve the quality of the operation and the final result, in terms of capillary density, contemplating the study of cell differentiation of follicles with the required estimate of time required regarding the growth. Minimizes the positional discomfort of the patient, the pain associated with the administration of anaesthesia, among other inconveniences usually experienced by the patient in this type of intervention.

07/07/16
20160192853 

System and facilitating diagnosis of cardiac rhythm disorders with the aid of a digital computer


R-r interval data is presented in a format that includes relevant near field and far field ecg data. The near field view provides a “pinpoint” classical view at classical recording speed.
Bardy Diagnostics, Inc.


07/07/16
20160192626 

Method for creating endometriotic cells and endometriosis model animal


Provided is a method of producing a cell having properties of endometriosis (hereinafter referred to as “endometriotic-like cell”) from a human mesenchymal stem cell. Also provided are a method of producing an animal model exhibiting human endometriosis, the method including transplanting the cell to an animal, and an animal model of endometriosis.
Astellas Pharma Inc.


06/30/16
20160187493 

Variable metal multi-gate metal oxide semiconductor capacitor radiation sensor for improved gain and tissue equivalence


A method and apparatus is disclosed for differentially altering the radiation response across multiple moscap sensors by placing different thin gate materials with different atomic numbers on a series of mos-based radiation sensors. The secondary electrons created in high-atomic weight materials (such as gold) at lower incident photon energy levels enable a tissue equivalent radiation response and radiations source identification/differentiation.

06/30/16
20160187320 

Assay for screening compounds that selectively decrease the number of cancer stem cells


The present invention provides, inter alia, a method for identifying an agent that selectively decreases the number of cancer stem cells (cscs). This method includes (a) contacting a csc from a population of cells with a candidate agent; and (b) determining whether the candidate agent reduces the survival or growth of the csc or increases differentiation of the csc relative to a csc that has not been contacted with the candidate agent.

06/30/16
20160186144 

Epithelial cell differentiation of human mesenchymal stromal cells


The present invention relates to the discovery that different stem cell types (e.g., bone marrow-derived mesenchymal stem cells (bm-msc) and adipose-derived mesenchymal stem cells (at-msc)) undergo large changes in lung epithelial marker expression depending on the substrate on which they are cultured. The present invention includes methods and compositions for differentiating of mesenchymal stem cells, such as bone marrow and adipose tissue mesenchymal stem cells, into lung cells, populations of lung cells, and methods of alleviating or treating a lung defect in a subject in need thereof..

06/30/16
20160186141 

Small molecule cellular reprogramming to generate cardiomyocytes


Compositions and methods are described herein for chemically inducing cells to change their differentiation state and become cardiac progenitor cells or cardiomyocytes.. .

06/30/16
20160185872 

Compositions and methods for treating bone conditions


A method of treating a degenerative bone condition of a subject includes administering to hematopoietic progenitor cells or osteoclast progenitor cells of the subject at least one agent that substantially reduces the interaction of at least one of c3a or c5a with the c3a receptor (c3ar) and/or c5a receptor (c5ar), a stat3/il-6 signaling pathway antagonist, and a combination thereof, the agent being administered to the hematopoietic progenitor cells or osteoclast progenitor cells at an amount effective to inhibit osteoclast differentiation of hematopoietic progenitor cells or osteoclast progenitor cells.. .

06/30/16
20160185725 

C-met modulators and use


The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-met, kdf, c-kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions.

06/30/16
20160185481 

Slide opening display and mail package


An economical package comprising an inner sliding piece assembled inside of one or more outer sleeves, where the inner sliding piece may contain a gift card, loyalty card, product, or promotional messages, and the card, product or messages can be revealed by pulling the inner sliding piece at least partially out of the outer sleeve. The package assembly can provide differentiation, protection, consumer information, and an ability to reuse the package for presentation of the card or information..

06/30/16
20160184364 

Management of osteoarthritis using pooled allogeneic mesenchymal stem cells


The present disclosure relates to a composition and method for management of osteoarthritis, including improvement in pain and cartilage regeneration of knee joint affected by osteoarthritis. The present disclosure also relates to a kit for treating osteoarthritis and the method of assembling the same.

06/23/16
20160178600 

Test strips for visual differentiation of liquid mixture composition


A test strip device exhibits visual changes, such as color changes, when there is a only slight difference in the composition of liquids such as gasoline, oil, ethanol and water. Such a slight liquid composition difference usually requires a sophisticated and expensive instrument to differentiate.

06/23/16
20160177368 

Selective enrichment medium for carbapenem-resistant bacteria


The present invention relates to a method for direct detection and differentiation of carbapenem-resistant bacteria in a sample comprising (i) inoculation with said sample of a culture medium comprising at least meropenem and/or ertapenem and at least one chromogenic agent, (ii) incubation of said culture medium under conditions allowing the growth of carbapenem-resistant bacteria, and (iii) detection of colonies formed on said culture medium corresponding to a carbapenem-resistant bacteria, as well as a culture medium suitable for use in such a method.. .

06/23/16
20160177267 

Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof


Disclosed herein are methods for generating sc-β cells using chemically defined, completely serum free media, and isolated populations of sc-β cells for use in various applications, such as cell therapy.. .

06/23/16
20160176927 

Peptide for suppressing osteoclast differentiation and use thereof


The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (il)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of nf-κb and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-b ligand (rankl)-rank signaling pathway, and suppresses the expression of a rankl or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (trap), cathepsin k, or tnf receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration.

06/23/16
20160175225 

Peptides and their use in the treatment of skin


Embodiments of the invention are related generally to the methods of diminishing the signs of aging in and/or improving health of human integuments, such as skin, and compositions comprising peptides useful therefor. The compositions according to the invention may comprise one or more peptides or fragments or derivatives thereof derived from a growth factor, e.g., growth differentiation factor 11 (gdf11), in a topically acceptable vehicle..

06/16/16
20160170777 

Modified jvm with multi-tenant application domains and class differentiation


A method and system for operating a modified java virtual machine (jvm) which is able to simultaneously host multiple java application programs is disclosed. In a first modification the jvm is modified to permit multiple class definitions of some of the java application programming interface (api) classes, so called non-sensitive classes, to be loaded multiple times but restrict other java api classes, so called sensitive classes, to be loaded only once, preferably onto a bootstrap class loader.
Waratek Limited


06/16/16
20160169911 

Marker for statin treatment stratification in heart failure


The present invention is directed to a method of identifying a patient having heart failure as likely to respond to a therapy comprising a statin. The method is based on measuring the level of at least one marker selected from gdf-15 (growth differentiation factor 15), urea, shbg (sex hormone-binding globulin), uric acid, plgf (placental growth factor), il-6 (interleukin-6), transferrin, a cardiac troponin, sflt-1 (soluble fms-like tyrosine kinase-1), prealbumin, ferritin, osteopontin, sst2 (soluble st2), and hscrp (high sensitivity c-reactive protein) in a sample from a patient.
Roche Diagnostics Operations, Inc.


06/16/16
20160168535 

Generation of anterior foregut endoderm from pluripotent cells


The invention is directed to in vitro methods of inducing differentiation of anterior foregut endoderm and the enriched populations of anterior foregut endoderm produced by such methods. Such enriched populations are useful for studies of the molecular events that occur during differentiation and for generating cells for cell replacement therapy..
Mount Sinai School Of Medicine


06/16/16
20160168213 

Growth differentiation factor 15 (gdf-15) constructs


Constructs comprising gdf15, and mutants thereof are provided. In various embodiments the constructs comprising gdf15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder.
Amgen Inc.


06/16/16
20160168205 

Methods and compositions for labeling polypeptides


Synthesis of many proteins is tightly controlled at the level of translation and plays an essential role in fundamental processes such as cell growth and proliferation, signaling, differentiation or death. Methods that allow imaging and identification of nascent proteins allow for dissecting regulation of translation, both spatially and temporally, including in whole organisms.
President And Fellows Of Harvard College


06/16/16
20160166687 

Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate


The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent.
Irm Llc


06/16/16
20160166615 

Material for treatment of cerebral infarction


A material for treatment of cerebral infarction ameliorates angiopathy at a cerebral infarction region and improves brain function. The material for treatment of cerebral infarction according to the present invention comprises a dental pulp stem cell including at least one of a cd105-positive cell, an sp cell, a cd24-positive cell, a cd271-positive cell, and a cd150-positive cell.
National Center For Geriatrics And Gerontology


06/09/16
20160163227 

Methods and devices for intraoral tactile feedback


The present invention is directed to methods and devices for teaching the proper configuration of the oral articulators, particularly the tongue, corresponding to particular speech sounds by providing intraoral tactile feedback. Intraoral tactile feedback is achieved by placing nodes in the oral cavity of the patient in locations corresponding to the proper lingual position required to produce a target sound.
Articulate Technologies, Inc.


06/09/16
20160161464 

Stem cell differentiation determination device, method, and program


A stem cell differentiation determination device includes an observation image acquisition unit that captures an image of an observation region including a stem cell in time series to acquire at least two observation images, a feature amount acquisition unit that acquires at least one feature amount of the stem cell for each observation image, a determination unit that determines whether or not the stem cell has been differentiated, on the basis of the feature amount, a change information acquisition unit that acquires information about a change in the feature amount between the observation images captured in time series or information about a change in a determination result from undifferentiation to differentiation between the observation images, and an output unit that outputs the information about a change in the feature amount or the information about a change in the determination result.. .
Fujifilm Corporation


06/09/16
20160160219 

Composition containing ppar-gamma neddylation inhibitor for inhibiting adipocyte differentiation and use thereof


Provided is a method for suppressing an adipose differentiation comprising administering to a subject in need thereof a ppar-v neddylation inhibitor for inhibiting adipocyte differentiation and a method for screening an adipocyte differentiation inhibitor using ppar-v neddylation associated with adipocyte differentiation. The inhibitor of a neddylation pathway of ppar-v inhibits the differentiation from mesenchymal stem cells to mast cells, and thus can be effectively used to treat obesity, and particularly, can be also useful in the treatment of severe obesity which cannot be excepted to be treated by existing obesity treatment agents..
Seoul National University R&db Foundation


06/09/16
20160160184 

Methods for reprogramming cells and uses thereof


Described herein are reprogrammed cells, and methods for cell dedifferentiation, transformation and eukaryotic cell reprogramming. Also descried are cells, cell lines, and tissues that can be transplanted in a patient after steps of in vitro dedifferentiation and in vitro reprogramming.
Novagenesis Foundation


06/09/16
20160160182 

Differentiation of human pluripotent stem cells


The present invention provides a method for increasing the expression of mafa in cells expressing markers characteristic of the pancreatic endocrine lineage comprising the steps of culturing the cells expressing markers characteristic of the pancreatic endocrine lineage in medium comprising a sufficient amount of a cyclin-dependent kinase inhibitor to cause an increase in expression of mafa.. .
Janssen Biotech, Inc.


06/09/16
20160160177 

Method and medium for neural differentiation of pluripotent cells


The invention relates to a culture medium comprising an inhibitor of the bmp signaling pathway; and an inhibitor of the tgf/activin/nodal signaling pathway and to a method for obtaining a population of neural precursors using said culture medium.. .
Association Francaise Contre Les Myopathies


06/09/16
20160158163 

Method for treating gefitinib-resistant non-small-cell lung cancer


The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (nsclc) comprising administering an effective amount of a resveratrol analogue, (z)3,4,5,4′-tetramethoxystilbene (tms), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant nsclc cells comprising contacting the resveratrol analogue to the cells at an effective amount.
Macau University Of Science And Technology


06/09/16
20160158152 

Pharmaceutical composition for the treatment of diminution of bone tissue


A method for prevention and/or treatment of diminution of bone tissue using a composition comprising a compound selected from withaferin a (wfa), withanolide a, and withanone. The composition showed enhanced wfa bioavailability in rodents against plain wfa, promotes bone marrow cell differentiation, and increases the percent of bone volume to tissue volume (bv/tv%) by 3 folds as compared to free withaferin a (wfa)..
Council Of Scientific & Industrial Research


06/09/16
20160157470 

Non-human animals having a humanized cluster of differentiation 47 gene


Non-human animals, and methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of an endogenous cluster of differentiation (cd) gene, in particular a humanization of a cd47 gene. Said non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous cd47 gene so that said non-human animals express a cd47 polypeptide that includes a human portion and a non-human portion (e.g., a murine portion)..
Regeneron Pharmaceuticals, Inc.


06/09/16
20160157469 

Non-human animals having a humanized cluster of differentiation 274 gene


Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a cluster of differentiation 274 (cd274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous cd274 gene so that said non-human animals express a programmed cell death ligand 1 (pd-l1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion)..
Regeneron Pharmaceuticals, Inc.


06/02/16
20160153871 

Cytoplasmic stain composition


Disclosed is a composition of cytoplasm stain for use in differentiation of cell nuclei from cell cytoplasmic components and differentiation of specific cytoplasm components by tinctorial contrast. Specifically, the invention relates to stain composition utilized as a counter stain in the hematoxylin and eosin procedure for use in histological and cytological microscopic evaluation of tissue and cells.

06/02/16
20160152950 

Methods of maintaining, expanding and differentiating neuronal subtype specific progenitors


Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors..
Wisconsin Alumni Research Foundation


06/02/16
20160152677 

Single domain tdf-related compounds and analogs thereof


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
Thrasos Innovation, Inc.


06/02/16
20160152674 

Tdf-related compounds and analogs thereof


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
Thrasos Innovation, Inc.


06/02/16
20160151717 

Reconfigurable plush toy


Improvements in a reconfigurable plush toy that is filled with material that allows the toy to be crushed, and washed without harm to the user. The plush toy can be used by infants to young children that can reconfigure the reconfigurable plush toy from known to imaginable toys.

06/02/16
20160150767 

Mirna-regulated differentiation-dependent self-deleting cassette


Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell.
Regeneron Pharmaceuticals, Inc.


05/26/16
20160150152 

Photographing method and apparatus


A digital camera is provided with a frequency component extraction unit, an ar evaluation value acquisition unit, a variation calculation unit, and a moving speed control unit. The frequency component extraction unit has first and second filters, and extracts first and second spatial frequency components.
Fujifilm Corporation


05/26/16
20160146447 

Heat-dissipating socket for lighting fixtures


An led lighting assembly, including a socket member operable to electrically communicate with a solid-state lighting element, at least two electrical connections extending into the socket member for electrically communicating with a solid-state lighting element, at least two electrical receivers extending into the socket member and capable of electrical communication with the at least two electrical connections, a differentiation groove embedded in the socket member, a driver element in electrical communication with the at least one socket member, and a heat-dissipating member operationally connected to the socket member. Other implementations include securing and energizing the solid-state lighting element by inserting the solid-state lighting element into the socket member and twisting; polarity-specific electrical connections using uniquely sized electric receivers and/or electrical connectors; and active and/or passive heat dissipation..

05/26/16
20160145641 

Stepwise differentiation of stem cells for the production of eukaryotic membrane proteins


A method useful for making a eukaryotic membrane protein in vitro may be carried out by (a) propagating in vitro vertebrate stem cells; (b) transforming the vertebrate stem cells in vitro with a heterologous expression vector containing a nucleic acid encoding the eukaryotic membrane protein; and then (c) differentiating the stem cells in vitro into differentiated cells (or photoreceptor-like cells) that express the membrane protein.. .
Uab Research Foundation


05/26/16
20160145578 

Method for differentiation of pluripotent stem cells into multi-competent renal precursors


This application relates to a method for differentiating pluripotent stem cells (pscs) into multi-competent renal precursor cells expressing six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes.
Hoffmann-la Roche Inc.


05/26/16
20160145574 

Kit and promoting mesenchymal stem cell differentiation


The present invention is related to a kit comprising: (a) a mesenchymal stem cell; (b) a gelatin-hyaluronan-chondroitin tri-copolymer scaffold; (c) a kartogenin; and (d) a bioreactor. The present invention is also related to a method for promoting differentiation of a mesenchymal stem cell into cartilage tissue, comprising: (a) culturing the mesenchymal stem cell on a gelatin- hyaluronan-chondroitin tri-copolymer scaffold in the presence of a kartogenin; and (b) culturing the mesenchymal stem cell and the gelatin-hyaluronan-chondroitin tri-copolymer scaffold in a bioreactor..
National Taiwan University


05/26/16
20160145350 

Antibodies against cd73 and uses thereof


The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human cluster of differentiation 73 (cd73) with high affinity, and inhibit the activity of cd73, and optionally mediate antibody dependent cd73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided.
Bristol-myers Squibb Company


05/26/16
20160145250 

Anti-cancer compounds


Provided are methods and compositions for the treatment of diseases such as cancer. In certain aspects, compounds which can inhibit skp2 are provided.
Board Of Regents, The University Of Texas System


05/26/16
20160144075 

Bone matrix compositions and methods


Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity.
Warsaw Orthopedic, Inc.


05/26/16
20160143940 

Vehicle for delivering a compound to a mucous membrane and related compositions, methods and systems


Psa is delivered to the host by outer membrane vesicles (omvs), secretion structures that target bacterial molecules to host cells. Purified omvs direct the in vitro differentiation of functional tregs with potent suppressive activity in a psa dependent manner.
California Institute Of Technology


05/26/16
20160143939 

Compositions, kits and methods for treatment of cardiovascular,immunological and inflammatory diseases


Compositions, kits, cells and methods for treating cardiovascular (e.g., myocardial ischemia and heart failure), immunological, and inflammatory diseases or disorders involve the use of the mature and precursor sequences of micrornas 142-5p, 142-3p, 17-5p, 17-3p, 374, and 20a, and of antisense molecules complementary to these sequences, to manipulate processes relevant to, for example, the cardiac response to stress, including survival signaling, angiogenesis, stem cell differentiation along muscle or vascular lineages, and repression or promotion of cardiac myocyte growth. Also described are methods to treat cardiovascular, immunological and inflammatory diseases by engineering cells containing specific micro-rnas or antagomirs against specific mrnas.
University Of Miami


05/26/16
20160143877 

Composition for suppressing adipocyte differentiation, for reducing fat accumulation and/or for promoting adiponectin secretion and usage for said composition


The present invention relates to a composition for suppressing adipocyte differentiation, for reducing fat accumulation in adipocytes and/or for promoting adiponectin secretion from adipocytes, including sesaminol as an active component. The present invention also relates to a method for suppressing adipocyte differentiation, for reducing fat accumulation in adipocytes and/or for promoting adiponectin secretion of adipocytes, including administering a composition including sesaminol as an active component..
Kiyomoto Iron & Machinery Works Co Ltd


05/19/16
20160140303 

Value-based health care management systems and methods


A system and method are disclosed for management of patient care and research using a combination of value-based methodology and translational research methodology. The system includes software to generate a single outcome measurement, or “value-quotient (vq)” expressing a delivered health value and the associated costs.
The Regents Of The University Of California


05/19/16
20160138094 

Direct, programmable detection of epigenetic dna cytosine modifications using tal effectors


The present invention relates to methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest o,r (ii) said unmodified cytosine residue of interest, said methods making use of the capability of transcription-activator-like effector (tale) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of tale proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest or (ii) said unmodified cytosine residue of interest..
UniversitÄt Konstanz


05/19/16
20160138024 

Screening compound having obesity preventive or therapeutic activity


A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action.

05/19/16
20160138017 

Microrna and uses in brown fat differentiation


This invention reveals a novel mirna and a novel mirna-regulated signaling network which controls brown adipogenesis and thermogenic programs, thereby providing a powerful approach for the treatment of obesity and related metabolic diseases. In this regard, the present invention is also directed towards methods of treatment of obesity and excess weight (overweight) and metabolic disorders caused by or aggravated by a subject being overweight or obese..
Joslin Diabetes Center, Inc.


05/19/16
20160137982 

P38 mapk inhibitor-containing medium and osteogenic differentiation


Here is provided a novel differentiation protocol, which was experimentally shown to give rise to osteoprogenitor cells in vitro. A novel medium composition containing a p38 mapk inhibitor was found to promote differentiation of human adipose stem cells (hascs) to osteoprogenitor cells.
Tampereen Yliopisto


05/19/16
20160137981 

Induced pluripotent stem cell selection method and inducing differentiation to blood cells


A method for producing hematopoietic stem cells and/or hematopoietic progenitor cells from pluripotent stem cells is described. The method includes a step of culturing pluripotent stem cells in the presence of igf2.
Kyoto University


05/19/16
20160137975 

Generation of male germ cells


Methods are provided for the generation of male germ cells from somatic cells. Included are methods of non-integrative reprogramming for germ cell differentiation with a reduced risk of neoplasia during in vivo differentiation by the inclusion of vasa with the reprogramming factors.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


05/19/16
20160137707 

Synaptogenic protein tagged with biotin and reconstitution of artificial synapse by using same


Disclosed is a polypeptide containing an extracellular domain of a synaptogenic protein, and a method for manufacturing a nerve cell, a complex containing a biotin tagged at the c-terminus of the polypeptide, an artificial synapse inducer for coupling the composite to a streptavidin (sav)-coated substrate and a nerve cell. The complex tagged with a biotin at the c-terminus of the polypeptide containing the extracellular domain of the synaptogenic protein, such as neuroligin-1, can display activity by being attached to the sav-coated substrate to adjust the orientation thereof without help of a supported lipid bilayer.
Seoul National University R&db Foundation


05/19/16
20160136310 

Systems, compositions, and methods for local imaging and treatment of pain


Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission.
The Regents Of The University Of California


05/12/16
20160130559 

Cell populations, methods of transdifferentiation and methods of use thereof


The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes..
Tel Hashomer-medical Research, Infrastructure And Services Ltd.


05/12/16
20160130556 

Enhanced differentiation of mesenchymal stem cells


Isolated populations of mesenchymal stem cells (mscs) are provided, including mammalian mesenchymal stem cells (mscs) characterized by the lack of cd54 (cd54−) or low cell-surface cd54 (cd54low). Methods of in vitro cell differentiation and methods of treatment using said isolated populations are also provided..
Escape Therapeutics, Inc.


05/12/16
20160130554 

Reprogramming mesenchymal stromal cells into hematopoietic cells


Method for reprogramming of stromal cells into hematopoietic cells are provided. Also provided are mesenchymal stromal cells that can be reprogrammed into hematopoietic cells.
Wake Forest University Health Sciences




Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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