|| List of recent Differentiation-related patents
|System and method for analyzing hospitality industry data and providing analytical performance management tools|
Hospitality customer acquisition and retention costs are analyzed on a per-channel, channel-agnostic, and aggregated basis. Hotel performance is analyzed by examining net revenue by channel (accounting for each channel's contribution to operating expenses and profits), net revenue in aggregate (via net revpar and revpar capture metrics), and the relative benefit of sales and marketing expenses by quantifying net sales and marketing efficiency.
|Compositions and methods for osteogenic gene therapy|
The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth.
|Small chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound|
A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of es cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of es cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells.
|Method of producing erythrocytes without feeder cells|
Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place..
|Osteoinductive demineralized cancellous bone|
An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone.
|System, apparatus, and method for enhancing stereoscopic images|
The ability of some people to perceive simulated stereoscopic images or even actual stereoscopic images can be enhanced by treating the two eyes differently. The disclosed system can enhance stereoscopic images by selectively modifying the incoming images using right/left differentiation filter.
|Systems, apparatus, and methods for providing continuous-time signal differentiation and integration|
Systems and methods for providing an approximate differentiation and integration of an input continuous-time signal are provided. The disclosed systems include a continuous-time delay block configured to receive an input continuous-time signal and to delay the input continuous-time signal by a predetermined delay factor to generate a delayed input continuous-time signal, a processing block configured to determine a difference or a sum between two continuous-time signals, and a multiplication block configured to multiply an input continuous signal to provide a multiplied input continuous signal..
|Compositions and methods for restoring the stratum corneum and treating dermatological diseases|
The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to restore the stratum granulosum and stratum corneum and treat a dermatological disease, such as, for instance atopic dermatitis. More specifically it provides terpenes and terpenoids such as monoterpenoids, sesquiterpenes and norisoprenoids as ingredients that work to restore and thicken the stratum granulosum and stratum corneum and treat a dermatological disease.
|Malignant and non-malignant disease treatment with ras antagonists|
The present disclosure describes new inhibitors or antagonists of ras useful for the treatment of conditions resulting from ras-induced or mediated cellular processes, including cellular proliferation, differentiation, apoptosis, senescence, and survival. These cellular processes may be associated with a non-malignant or malignant disease, disorder, or pathological condition.
|Method of differentiation of morula or inner cell mass cells and method of making lineage-defective embryonic stem cells|
An improved method of producing differentiated progenitor cells comprising obtaining inner cell mass cells from a blastocyst and inducing differentiation of the inner cell mass cells to produce differentiated progenitor cells. The differentiated progenitor cells may be transfected such that there is an addition, deletion or alteration of a desired gene.
|Methods of maintaining, expanding, and diffrentiating neuronal subtype specific progenitors|
Methods for expanding proliferating populations of neuronal subtype-specific progenitors are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors..
|Cytoplasmic stain composition|
A composition of two cytoplasm stains for use in differentiation of cell nuclei from cell cytoplasmic components and differentiation of specific cytoplasm components by tinctorial contrast. Specifically, the invention relates to two stain compositions utilized as a counter stain in the hematoxylin and eosin procedure for use in histological and cytological microscopic evaluation of tissue and cells.
|Methods and devices for intraoral tactile feedback|
The present invention is directed to methods and devices for teaching the proper configuration of the oral articulators, particularly the tongue, corresponding to particular speech sounds by providing intraoral tactile feedback. Intraoral tactile feedback is achieved by placing nodes in the oral cavity of the patient in locations corresponding to the proper lingual position required to produce a target sound.
|Gamma-diketones as wnt/beta -catenin signaling pathway activators|
The present disclosure provides γ-diketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .
|Novel peptide derivatives for treatment, prevention or alleviation of a condition associated with bone loss or low bone density or to inhibit osteoclast differentiation and stimulation|
Compounds of formula r1-a-nh—ch(r2)—co—r3 are presented. The compounds can be used to treat or alleviate conditions associated with bone loss or low bone density, or to inhibit osteoclast differentiation and stimulation, bone resorption and/or loosening of a prosthetic device.
|Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells|
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation.. .
|Neural progenitor cell populations|
This invention provides populations of neural progenitor cells, differentiated neurons, glial cells, and astrocytes. The populations are obtained by culturing stem cell populations (such as embryonic stem cells) in a cocktail of growth conditions that initiates differentiation, and establishes the neural progenitor population.
|Methods and compositions for modulating the innate immune response and/or myogenesis in a mammalian subject|
In one aspect, the present invention relates to methods for increasing, decreasing or maintaining the innate immune response in a mammalian subject comprising modulating the expression of dux4-fl, or modulating the expression of beta-defensin 3 (defb103). In another aspect, the present invention relates to methods for increasing, decreasing or maintaining myogenesis or muscle differentiation in a mammalian subject comprising modulating the expression of beta-defensin 3 (defb103).
|Method for using directing cells for specific stem/progenitor cell activation and differentiation|
A method is provided, including obtaining a population of antigen-presenting cells, enriching a population of stem/progenitor cells within a larger population of cells, activating the population of antigen-presenting cells and, following the activating, inducing at least one process selected from the group consisting of: differentiation, expansion, activation, secretion of a molecule, and expression of a marker, by exposing the enriched stem/progenitor cell population to the population of antigen-presenting cells. Other applications are also described..
|4-aminoquinazoline derivatives and uses thereof|
The present invention provides a 4-aminoquinazoline derivative having the chemical structure of the following formula, and the use thereof. It is demonstrated by the pharmacological experiment that, the compound or a salt thereof according to the present invention not only has distinct inhibitory effect on histone deacetylases, but also has stronger differentiation induction and anti-proliferative activities for certain tumor cells.
|Modular, bioactive peptides for binding native bone and improving bone graft osteoinductivity|
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion.
|Methods for detection and differentiation of origin of viral dna|
The invention disclosed herein provides methods for identifying the origin of viral dna in a sample by detecting the methylation state of at least one cpg site on a target site of the genome of a virus of interest, and determining whether the origin of the viral dna is from a cell, such as a tumor cell, or a virion, wherein when the methylation state is positive for methylation, the viral dna is from a cell, and wherein when the methylation state is negative for methylation, the viral dna is from a virion. Use of these methods for diagnosis or monitoring, and/or treatment of a subject infected with a virus known to cause cancer and related disease are also provided..
|Th17 differentiation markers for acne and uses thereof|
A method is described for using ror gamma t or ror alpha to diagnose acne and/or to screen inhibitors of th17 differentiation. Specifically described are methods of inhibiting ror gamma t or ror alpha and use of the screened inhibitors in acne treatment..
|Service differentiation in a network sharing architecture|
In an embodiment, there is provided a method for service differentiation in a network sharing architecture for a mobile network wherein an access network an is shared by different service providers sps, said method comprising at least one step based on an identification of an sp by an sp identity that does not require this sp to own a plmd-id, for service differentiation in said an.. .
|Induction of hemogenic endothelium from pluripotent stem cells|
Described herein are methods and related compositions for inducing differentiation of human pluripotent stem cells (hpscs) into hemogenic endothelium with pan-myeloid potential or restricted potential, by forced expression in the hpscs of a combination of transcription factors as described herein.. .
|Methods for enhancing genome stability and telomere elongation in embryonic stem cells|
The disclosure provides methods for increasing genome stability of an embryonic stem (es) cell or induced pluripotent stem (ips) cell, increasing telomere length in an es or ips cell, or both, for example by contacting an es or ips cell with an agent that increases expression of zscan4 in the cell. Methods for increasing genome stability or increasing telomere length in a population of es or ips cells are provided, for example by selecting zscan4+ es or ips cells from the population of es or ips cells (which can include both zscan4+ and zscan4− es or ips cells).
|Triazine derivatives as differentiation catalysts|
A method of inducing differentiation of mammalian cells into cardiomyocyte-like cells by contacting the mammalian cell with a triazine compound of formula (i), wherein x is independently —nr4— or —o—, r4 is hydrogen or c1-6-alkyl; r1 is hydroxy, c1-6-alkyl, c1-6-alkoxy, carboxy, c1-6-alkoxycarbonyl, halo, cyano, nitro, formyl, amino, c1-6-alkylamino, or di-c1-6-alkylamino, the c1-6-alkyl or -alkoxy residue being optionally substituted with one or more r5 substituents selected from hydroxy, halo, cyano, and nitro; n is 0 to 5; r2 is hydrogen, aryl, heteroaryl, or c1-6-alkyl, the aryl or heteroaryl residue being optionally substituted with one or more r1 substituents, and where the c1-6-alkyl is optionally further substituted with one or more r5 substituents; and r3 is selected from hydrogen, halo, nr4r7, or7, sr7, and r7, where the same options apply for r7 as for r2; with the proviso that the compound of formula (i) is not 3-[(4,6-diphenoxy-1,3,5-triazin-2-yl)amino]benzoic acid.. .
|Engineered cellular pathways for programmed autoregulation of differentiation|
The present invention provides compositions and methods for programming mammalian cells to perform desired functions. In particular, the present invention provides compositions and methods for programming stem cells to differentiate into a desired cell type.
|Use for glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medical-plant derived ligand|
The present invention relates to glycolipoprotein gintonin, isolated and identified from ginseng, as a natural medicinal-plant-derived ligand acting on lpa1 (lysophosphatidic acid; 1- or 2-acyl-sn-glycerol-3-phosphate), lpa2, lpa3, lpa4 and lpa5 receptors whose efficacy is exhibited physiologically/pharmaceutically via an interaction with subset receptors [lpa1(edg-2), lpa2(edg-4), lpa3(edg-7), lpa4, pla5] in the edg (endothelial differentiation gene) family in g protein-coupled receptors (gpcrs) present in the cell membranes of animals including humans. The gintonin of the present invention can be used to advantage in the prevention and treatment of various diseases arising from reduced calcium concentration and various physiological activities and pharmaceutical activities dependent on calcium, since the gintonin of the present invention interacts with lpa receptors so as to activate a series of signal transmission processes and temporarily induce an increase in free ca2+ in the cytoplasm, and a temporary increase in the intracellular calcium concentration gives rise to a temporary increase in the intracellular calcium concentration in various organs including, inter alia, those of the nervous system, cardiovascular system, endocrine system, reproductive system, digestive system and immune system when the lpa receptors are expressed, with physiological activity being exhibited..
|Interactive learning system|
The present invention provides a system and method for interactively teaching phonics via an electronic device. The present invention enables a user to provide at least two forms of user input: oral and written, and the system recognizes these forms of input to provide feedback and load subsequent content based on user performance.
|Endometrial derived stem cells and their methods of use|
The present invention provides a method of making an insulin-producing cell derived from an endometrial stromal stem cell (essc). The invention includes the progeny of essc, including any cell type generated during the differentiation of essc towards cells that produce insulin and exhibit cell markers characteristic of insulin producing cells.
|Cellular and molecular therapies|
The present invention provides, among other things, improved compositions and methods for the treatment of tissue damage (e.g., acute or chronic) and related diseases, disorders or conditions based on the use of pathfinder cells, extracellular secretomes thereof, and/or pathfinder cell-associated micrornas. In some embodiments, the present invention provides a method for treating tissue damage (e.g., acute or chronic) comprising a step of administering a population of cells to an individual suffering from a disease, disorder or condition characterized by acute damage to one or more tissues, wherein the cells are originated from an adult tissue and wherein the cells induce tissue repair, regeneration, remodeling, reconstitution or differentiation.
|Heteroaromatic compounds as pi3 kinase modulators and methods of use|
The present invention provides heteroaromatic derivatives and pharmaceutical acceptable salts and formulations thereof useful in modulating the protein kinase activity, especially phosphatidylinositol 3-kinases (pi3 kinases) and mtor, and in modulating inter- and/or intra-cellular signaling activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
|Method for inducing hepatocellular variation, and production method for chimeric non-human animal having humanized liver|
The present invention provides (1) a method for producing a non-human animal having a humanized liver, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, (2) a non-human animal having a humanized liver, produced by the method, (3) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using the animal, (4) a method for producing human hepatocytes, comprising transplanting human hepatic stem cells and/or hepatic progenitor cells and/or immature hepatocytes to a liver-damaged non-human animal to induce the differentiation of the cells into hepatocytes, and (5) a method for examining the pharmacokinetics and/or hepatotoxicity of a test substance, comprising using human hepatocytes produced by the method.. .
|Feature differentiation image capture unit and method in a surgical instrument|
In a minimally invasive surgical system, an image capture unit includes a prism assembly and sensor assembly. The prism assembly includes a beam splitter, while the sensor assembly includes coplanar image capture sensors.
|Modified and stabilized gdf propeptides and uses thereof|
Modified and stabilized propeptides of growth differentiation factor proteins, such as gdf-8 and bone morphogenetic protein-11, are disclosed. Also disclosed are methods for making and using the modified propeptides to prevent or treat human or animal disorders in which an increase in muscle tissue would be therapeutically beneficial.
|Nanomagnetic detector array for biomolecular recognition|
A biomolecular sensor system includes an array of magnetoresistive nanosensors designed for sensing biomolecule-conjugated superparamagnetic nanoparticles. Materials and geometry of each sensor element are designed for optimized sensitivity.
|Tissue engineering methods and compositions|
Cells are employed in conjunction with unique biologically-compatible scaffold structures to generate differentiated tissues and structures, both in vitro and in vivo. The presently disclosed subject matter further relates to methods of forming and using improved tissue engineered scaffolds that can be used as substrates to facilitate the growth and differentiation of cells..
|Regeneration of spinal discs|
Compositions and processes for the effective and efficient regeneration of spinal discs are provided. These compositions contain stem cells, donor cells, and platelet plasma compositions.
|Semipermeable medical pouches and their uses|
A novel process for bacterial production of nanocellulose hydrogel pouches for applications for cell therapy, cell encapsulation, cell delivery, cell proliferation and cell differentiation has been invented. The process is based on fermentation of bacteria producing nanocellulose in oxygen permeable mold interconnected with tubing with diameter less than 5 mm.
|Th17 differentiation markers for acne and uses thereof|
A method is described for using il-12r 1/il-23r, ccr6, batf, ahr, stat3, irf4 crucial actors in th17 cells differentiation as markers for acne. Also described are method of their use to diagnose acne, to screen inhibitors of th17 differentiation.
|Differentiation modulating agents and uses therefor|
The present invention is directed to methods and agents for modulating the differentiation potential and/or proliferation of preadipocytes. More particularly, the present invention discloses methods and agents for modulating a fibroblast growth factor (fgf) signaling pathway, especially the fgf-1 or fgf-2 signaling pathway, for treating or preventing adiposity-related conditions including, but not limited to, obesity, lipoma, lipomatosis, cachexia or lipodystrophy or the loss of adipose tissue in trauma or atrophic conditions..
|Th-17 differentiation markers for rosacea and uses thereof|
A method is described that uses ror gamma t, or ror alpha to diagnose rosacea and/or to screen inhibitors of th17 differentiation, notably in inhibiting ror gamma t or ror alpha. Also described is a method of using these screened inhibitors in rosacea treatment..
|Method for obtaining a multicellular spheroid|
The invention provides a method for producing a multicellular spheroid comprising injecting a cell suspension into a gel. The invention also provides a method of producing a gel comprising one or more multicellular spheroids, the method comprising injecting a cell suspension into a gel, as well as a gel obtainable by the method.
|Troponin and bnp based diagnosis of risk patients and cause of stroke|
Method for early differentiation of whether a subject suffers from cardioembolic stroke or from non-cardioembolic ischemic stroke based on the determination of the amount of a cardiac troponin in a sample from a subject who is suffering from ischemic stroke, the sample obtained not more than 24 hours after the onset of symptoms of ischemic stroke. Kits and devices adapted to carry out the methods are also provided..
|Ectocornea-like sheet and method of constructing the same|
It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells.
|Network congestion control with adaptive qos bit-rate differentiation|
A method is provided for congestion control in a network node (114; 510; 700; 900) of a communication network (701). The network node handles a plurality of data connections (dc1−n; rab1−n) for conveying data between a first side and a second side of the communication network.
|Slide opening display and mail package|
An economical package comprising an inner sliding piece assembled inside of one or more outer sleeves, where the inner sliding piece may contain a gift card, loyalty card, product, or promotional messages, and the card, product or messages can be revealed by pulling the inner sliding piece at least partially out of the outer sleeve. The package assembly can provide differentiation, protection, consumer information, and an ability to reuse the package for presentation of the card or information..
|Methods and compositions for diagnosis and prognosis of renal injury and renal failure|
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of heat shock 70 kda protein 1, alpha-1-antitrypsin neutrophil elastase complex, stromelysin-1:metalloproteinase inhibitor 2 complex, 72 kda type iv collagenase:metalloproteinase inhibitor 2 complex, insulin-like growth factor 1 receptor, myeloid differentiation primary response protein myd88, neuronal cell adhesion molecule, and tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries..
|Passaging and harvesting formulation and method for human pluripotent stem cells|
Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to dislodge cells from cell culture vessels. The formulations and methods permit the harvesting of cells as large clusters from the surface of various cell culture vessels including multilayer cell culture vessels.
|Screening method for therapeutic agent for chondropathy and modified chondrocyte for treatment of chondropathy|
The use of salt-inducible kinase 3 allows screening for a substance having an effect of increasing cartilage volume and/or an effect of normalizing chondrocyte differentiation. A modified chondrocyte in which the expression or function of salt-inducible kinase 3 gene is inhibited or enhanced can be used to ameliorate a disease associated with reduced cartilage volume and/or a disease associated with impaired cartilage growth..
|Human metabolically active brown adipose derived stem cells|
A method of distinguishing a brown adipose cell from a white adipose cell. In one embodiment the method includes measuring the expression level of one or more genes in an adipose cell; comparing the measured expression levels to a control, and correlating the expression level of the one or more genes to an identity as a white adipose cell or a brown adipose cell.
|Downregulation of mir-7 for promotion of beta cell differentiation and insulin production|
A method of ex-vivo increasing insulin content in beta cells or stem cells is disclosed. The method comprising contacting the beta cells or stem cells with an agent for downregulating an activity or expression of mir-7, thereby increasing the insulin content in the beta cells or stem cells..
|Method of isolating human neuroepithelial precursor cells from human fetal tissue|
A method for isolating human neuroepithelial precursor cells from human fetal tissue by culturing the human fetal cells in fibroblast growth factor and chick embryo extract and immunodepleting from the cultured human fetal cells any cells expressing a2b5, ng2 and encam is provided. In addition, methods for transplanting these cells into an animal are provided.
|Determining root sequence|
It is presented a method, executed in a root sequence determiner for a base station controlling a first cell, the first cell being associated with at least one root sequence used for cell differentiation on a random access channel. The method comprises the steps of: obtaining information on root sequences of neighbouring cells; when a root sequence conflict is found between the first cell and a neighbouring cell, here denoted a conflict cell, determining if the conflict cell is of a higher priority than the first cell, the priorities of the first cell and the conflict cell being based on properties of the respective cells; and when the conflict cell is of a higher priority than the first cell, finding a new root sequence for the first cell, avoiding the root sequences of the neighbouring cells..
|Price differentiation by market for in-app software purchases|
Different prices may be charged for an in-app purchase (iap) for a same item based on a market associated with the user. For example, a user in one market may be charged a different price for an item than what is charged for the item to a user in a different market.
|System and method for multiple product and price discovery|
A system and computer-implemented method are disclosed for optimizing product purchasing to enable consumers to efficiently locate and purchase multiple goods and/or services. A centralized product and price discovery system employs a computer implemented method for determining an optimized purchasing plan using user defined and system defined preferences including the cost of individual products at different locations, product specification differentiation (size, weight, origin of manufacture, user rating), and the cost and/or time to obtain the products from those locations.
|Three-dimensional cell culture methods for test material assessment of cell differentiation|
The present specification discloses three-dimensional in vitro cell-based methods to assess a test matrix polymer ability to support differentiation of a population of cells methods of screening a material for its ability to stimulate cell growth and/or differentiation.. .
|Antagonist anti-cd40 monoclonal antibodies and methods for their use|
Compositions and methods of therapy for treating diseases mediated by stimulation of cd40 signaling on cd40-expressing cells are provided. The methods comprise administering a therapeutically effective amount of an antagonist anti-cd40 antibody or antigen-binding fragment thereof to a patient in need thereof.
|Treatment of cardiovascular disorders using the cell differentiation signaling protein nell1|
It has been identified in accordance with the present invention that nell1 is essential for normal cardiovascular development by promoting proper formation of the heart and blood vessels. The present invention therefore provides therapeutic methods for treating cardiovascular disorders by employing a nell1 protein or nucleic acid molecule..
|Systems and methods for multi-broadcast differentiation|
A system and method is disclosed for resolving false positives in a centralized, real-time automatic content recognition system that is ingesting, fingerprinting, and attempting to match for recognition purposes, multiple streams of broadcast content that are simultaneously arriving from a plurality of sources. In particular, the problem of identifying which specific broadcast of certain programming has been matched, including the episode of a series, as well as the channel, time zone and time of broadcast and whether the programing is being watched “live” as broadcast or from a dvr time-shifted source, is addressed.
Topographical features, such as projections or recesses, having a maximum dimension which is less than 3 μm, with the features being separated by a distance which is less than 10 μm are transferred to polyetheretherketone, on an industrial scale, by injection moulding relatively low viscosity peek, using a mould in which is arranged a master structure which carries the desired topography. The topographical features increase the water contact angle of a surface which includes them and such a modified surface has been shown to influence cell attachment and differentiation.
|Enzymatic production or chemical synthesis and uses for 5,7-dienes and uvb conversion products thereof|
Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet b (uvb) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the p450scc (cyp11a1) or cyp27b1 enzyme systems where the hydroxylase has an activity to hydroxylate position c20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced.
|Peptide bfp4 for promoting osteogenesis or vascularization and use thereof|
Disclosed are a peptide for promoting osteogenesis and vascularization, and the use thereof. The peptide has a low molecular weight so that it can be economically produced.