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Differentiation patents



      

This page is updated frequently with new Differentiation-related patent applications.




Date/App# patent app List of recent Differentiation-related patents
05/19/16
20160140303 
 Value-based health care management systems and methods patent thumbnailValue-based health care management systems and methods
A system and method are disclosed for management of patient care and research using a combination of value-based methodology and translational research methodology. The system includes software to generate a single outcome measurement, or “value-quotient (vq)” expressing a delivered health value and the associated costs.
The Regents Of The University Of California


05/19/16
20160138094 
 Direct, programmable detection of epigenetic dna cytosine modifications using tal effectors patent thumbnailDirect, programmable detection of epigenetic dna cytosine modifications using tal effectors
The present invention relates to methods for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest o,r (ii) said unmodified cytosine residue of interest, said methods making use of the capability of transcription-activator-like effector (tale) proteins to preferentially bind with strong affinity to nucleic acid sequences containing non-modified cytosine residues or 5-methyl modified cytosine residues, and to bind, if at all, with only strongly reduced affinity to nucleic acid sequences containing 5-hydroxymethyl modified cytosine residues. The present invention further relates to respective uses of tale proteins for the differentiation of a 5-hydroxymethyl modification of a cytosine residue of interest in a nucleic acid molecule from (i) a 5-methyl modification of said cytosine residue of interest or (ii) said unmodified cytosine residue of interest..
UniversitÄt Konstanz


05/19/16
20160138024 
 Screening  compound having obesity preventive or therapeutic activity patent thumbnailScreening compound having obesity preventive or therapeutic activity
A screening method including: a step for contacting a test substance and a synoviolin-gene-expressing cell; and a step for verifying the effect of the test substance on the synoviolin gene expression, or the effect thereof on synoviolin protein activity. An action which reduces the amount of adipose tissue and an action which inhibits induction of adipocyte differentiation are examples of an anti-obesity action.

05/19/16
20160138017 
 Microrna and uses in brown fat differentiation patent thumbnailMicrorna and uses in brown fat differentiation
This invention reveals a novel mirna and a novel mirna-regulated signaling network which controls brown adipogenesis and thermogenic programs, thereby providing a powerful approach for the treatment of obesity and related metabolic diseases. In this regard, the present invention is also directed towards methods of treatment of obesity and excess weight (overweight) and metabolic disorders caused by or aggravated by a subject being overweight or obese..
Joslin Diabetes Center, Inc.


05/19/16
20160137982 
 P38 mapk inhibitor-containing medium and  osteogenic differentiation patent thumbnailP38 mapk inhibitor-containing medium and osteogenic differentiation
Here is provided a novel differentiation protocol, which was experimentally shown to give rise to osteoprogenitor cells in vitro. A novel medium composition containing a p38 mapk inhibitor was found to promote differentiation of human adipose stem cells (hascs) to osteoprogenitor cells.
Tampereen Yliopisto


05/19/16
20160137981 
 Induced pluripotent stem cell selection method and  inducing differentiation to blood cells patent thumbnailInduced pluripotent stem cell selection method and inducing differentiation to blood cells
A method for producing hematopoietic stem cells and/or hematopoietic progenitor cells from pluripotent stem cells is described. The method includes a step of culturing pluripotent stem cells in the presence of igf2.
Kyoto University


05/19/16
20160137975 
 Generation of male germ cells patent thumbnailGeneration of male germ cells
Methods are provided for the generation of male germ cells from somatic cells. Included are methods of non-integrative reprogramming for germ cell differentiation with a reduced risk of neoplasia during in vivo differentiation by the inclusion of vasa with the reprogramming factors.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


05/19/16
20160137707 
 Synaptogenic protein tagged with biotin and reconstitution of  artificial synapse by using same patent thumbnailSynaptogenic protein tagged with biotin and reconstitution of artificial synapse by using same
Disclosed is a polypeptide containing an extracellular domain of a synaptogenic protein, and a method for manufacturing a nerve cell, a complex containing a biotin tagged at the c-terminus of the polypeptide, an artificial synapse inducer for coupling the composite to a streptavidin (sav)-coated substrate and a nerve cell. The complex tagged with a biotin at the c-terminus of the polypeptide containing the extracellular domain of the synaptogenic protein, such as neuroligin-1, can display activity by being attached to the sav-coated substrate to adjust the orientation thereof without help of a supported lipid bilayer.
Seoul National University R&db Foundation


05/19/16
20160136310 
 Systems, compositions, and methods for local imaging and treatment of pain patent thumbnailSystems, compositions, and methods for local imaging and treatment of pain
Pain factors are labeled with targeted agents or markers delivered into the body. The labeled pain factors are imaged with appropriate imaging tools in a manner allowing selective identification and localization of areas of pain source or transmission.
The Regents Of The University Of California


05/12/16
20160130559 
 Cell populations, methods of transdifferentiation and methods of use thereof patent thumbnailCell populations, methods of transdifferentiation and methods of use thereof
The present invention provides methods for the sequential and temporally-regulated administration of pancreatic transcription factors to induce non-pancreatic cells to transdifferentiate and mature along the pancreatic β-cell lineage. The present invention also provides methods for identifying, isolating and enriching transdifferentiation predisposed cells and methods for treating a degenerative pancreatic disorder such as diabetes..
Tel Hashomer-medical Research, Infrastructure And Services Ltd.


05/12/16
20160130556 

Enhanced differentiation of mesenchymal stem cells


Isolated populations of mesenchymal stem cells (mscs) are provided, including mammalian mesenchymal stem cells (mscs) characterized by the lack of cd54 (cd54−) or low cell-surface cd54 (cd54low). Methods of in vitro cell differentiation and methods of treatment using said isolated populations are also provided..
Escape Therapeutics, Inc.


05/12/16
20160130554 

Reprogramming mesenchymal stromal cells into hematopoietic cells


Method for reprogramming of stromal cells into hematopoietic cells are provided. Also provided are mesenchymal stromal cells that can be reprogrammed into hematopoietic cells.
Wake Forest University Health Sciences


05/05/16
20160123985 

Hematopoietic cell phenotyping using circulating cell-free markers


The present invention provides methods of classifying cluster of differentiation (cd) marker phenotype for hematopoietic cancer cells using multiple circulating cell-free cd markers in bodily fluid. In other aspects, treatment and disease progression of particular hematopoietic cancers can be monitored by measuring the levels of cd and other markers in bodily fluids of a patient..
Quest Diagnostics Investments Incorporated


05/05/16
20160123979 

Biomarkers for early diagnosis and differentiation of mycobacterial infection


Mycobacterial-specific biomarkers and methods of using such biomarkers for diagnosis of mycobacterial infection in a mammal are disclosed.. .
Wisconsin Alumni Research Foundation


05/05/16
20160122826 

Use of id4 for diagnosis and treatment of cancer


Methods for diagnosis and treatment of cancer using id4 are disclosed. Specifically, epigenetic inactivation of id4 in colorectal carcinomas and breast correlates with poor differentiation and unfavorable prognosis.
John Wayne Cancer Institute


05/05/16
20160122803 

Early developmental genomic assay for characterizing pluripotent stem cell utility and safety


The present invention generally relates to a set of early developmental reference data or “lineage scorecard” for stem cells, and methods, systems and kits to generate a lineage scorecard for predicting the functionality and suitability of stem cell lines. In some aspects, methods for generating a scorecard comprises measuring the gene expression of a plurality of early developmental genes, such as pluripotent, early ectoderm, early mesoderm and early endoderm genes to predict the pluripotency and differentiation potential of the stem cell line and its functionality and/or suitability for a desired use.
President And Fellows Of Harvard College


05/05/16
20160122721 

Use of rna for reprogramming somatic cells


The present invention provides methods for de-differentiating somatic cells into stem-like cells without generating embryos or fetuses. More specifically, the present invention provides methods for effecting the de-differentiation of somatic cells to cells having stem cell characteristics, in particular pluripotency, by introducing rna encoding factors inducing the de-differentiation of somatic cells into the somatic cells and culturing the somatic cells allowing the cells to de-differentiate..
Johannes Gutenberg Universitat Mainz


05/05/16
20160122720 

Method of efficiently establishing induced pluripotent stem cells


The invention provides a method of producing ips cells, which comprises the steps of (i) introducing reprogramming factors into somatic cells; (ii) culturing the cells obtained in step (i) for more than 11 days and not more than 29 days; (iii) sorting tra-1-60-positive cells from the cells obtained in step (ii); (iv) culturing the tra-1-60-positive cells sorted in step (iii); (v) transferring a colony obtained in step (iv) to another culture vessel; and (vi) culturing the cells obtained in step (v), thereby obtaining ips cells. The cells obtained in step (v) are preferably subcultured 10 times or more.
Kyoto University


05/05/16
20160122719 

Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof


The present invention discloses novel compositions and methods for enhancing cardiac differentiation efficiency of stem cells or promoting ventricular and atrial cardiomyocytes formation from stem cells. The present invention also discloses the atrial and ventricular cardiomyocytes formed from the stem cells, and the uses of the cardiomyocytes for repairing cardiac injuries and screening for new medicaments for treating cardiac injuries..
Institute Of Biophysics, Chinese Academy Of Sciences


05/05/16
20160122717 

Differentiation of pluripotent stem cells and cardiac progenitor cells into striated cardiomyocyte fibers using laminins ln-511, ln-521 and ln-221


The present disclosure describes methods of differentiating cardiomyocyte progenitor cells and mature cardiomyocyte cells from pluripotent stem cells. The methods may include differentiating pluripotent stems cells on a substrate including (i) laminin-511 or 521 and (ii) laminin 221.
Biolamina Ab


05/05/16
20160122711 

Chemical differentiation of pluripotentstem cells into retinal epithelial cells


The present invention is based in part on a chemically defined method of generating retinal epithelial cells and retinal pigmented epithelial cells from human pluripotent stem cells (hpscs). The present invention also provides methods and kits for treating degenerative eye disorders..
International Stem Cell Corporation


05/05/16
20160122702 

Method for determining cell state and autoanalyzer using said method


There is provided a method for noninvasively evaluating the cell state (proliferation, multi-layering, and differentiation) of a cell sheet as a mimic tissue at the time of culturing the cell sheet. The method is characterized in that an analysis of an amino acid is conducted with the use of the culture supernatant of a cell sheet to monitor a change in the concentration of any amino acid selected from a group of 5-species of amino acids (ile, val, ser, leu, and ala), thereby making a determination..
Hitachi High-technologies Corporation


05/05/16
20160122402 

Retro polypeptides for activation immunity to cancer and viral infection


A polypeptide that drives t cell proliferation and differentiation, and methods and agents for modulating the expression and/or function of the polypeptide. Agents that up regulate the expression and/or function of the polypeptide are useful in the treatment or prevention of diseases and disorders that would benefit from stimulation of t cell proliferation and/or differentiation, such as cancer and chronic viral infections.
Imperial Innovations Limited


05/05/16
20160120945 

Thymic regeneration


Methods for regenerating thymic tissues, e.g., for the treatment of subjects who have thymic insufficiency, i.e., whose thymic tissues are absent or atrophied due to illness, age, or injury, by administration of growth differentiation factor 11 (gdf11).. .
Joslin Diabetes Center


04/28/16
20160119177 

Semi-polar modulator


A modulation processor (500) comprises a first processing stage (110) and a second processing stage (120). The first processing stage (110) comprises a phase generation stage (117) arranged to generate a phase signal (pm) indicative of a phase of a modulation signal (s), a differentiation stage (118) arranged to generate a frequency signal (fm) by differentiating the phase signal (pm), and a first bandwidth reduction stage (113) arranged to generate a first output signal (fm_lp) by reducing a bandwidth of the frequency signal (fm).
Telefonaktiebolaget L M Ericsson (publ)


04/28/16
20160115555 

Biomarkers for differentiating melanoma from benign nevus in the skin


Disclosed is a method for diagnosing melanoma in a human subject, as well as a method for providing a prognosis to a human subject who is at risk of developing melanoma recurrence, and a method for determining the stage of melanoma in a human subject, comprising the step of determining the level of expression of phosphatase and actin regulator 1 (phactr1) gene, or fragments thereof, either alone or in combination with the level of expression of secreted integrin-binding phosphoprotein (spp1), preferentially expressed antigen in melanoma (prame), growth differentiation factor 15 (gdf15), and chemokine c-x-c motif ligand 10 (cxcl10) genes. Further, the invention relates to a diagnostic kit, comprising at least one substance for detection of the expression of phactr1, or fragments thereof, either alone or in combination with the detection of spp1, prame, gdf15, and cxcl10, for the diagnosis or prognosis of melanoma..
Advanced Cell Diagnostics


04/28/16
20160115519 

Cell differentiation devices and methods


Methods, devices, and kits are provided for identifying, selecting, and/or manipulating live cells in a sample comprising a suspected mixed population of cells by subjecting the sample located in a first position to a linear gradient of a cellular stimulus to induce a change in a live cell sufficient to induce movement of the cell from a first position to a second position, wherein a dead cell, if present in the sample, is not induced to move to the second position in the presence of the cellular stimulus; and identifying or selecting the live cell in the second position.. .
Georgia Tech Research Corporation


04/28/16
20160115453 

Differentiation and expansion of endothelial cells from pluripotent stem cells and the in vitro formation of vasculature like structures


The disclosure is concerned among others with means and methods for obtaining endothelial cells and to means and methods for in vitro cell culture comprising endothelial cells and pericytes and/or smooth muscle cells derived from the pericytes. The endothelial cells or the pericytes and/or smooth muscle cells, or both, are preferably derived from in vitro differentiated pluripotent stem cells..
Academisch Ziekenhuis Leiden


04/28/16
20160115449 

Novel producing differentiated cells


The present invention has an object of providing a method for producing specific cells by amplifying cells in a desired differentiation stage. The present invention provides a method for producing specific cells by inducing differentiation of cells, wherein an oncogene is forcibly expressed in cells in a desired differentiation stage to amplify the cells in the desired differentiation stage.
The University Of Tokyo


04/28/16
20160115448 

Cortical interneurons and other neuronal cells produced by the directed differentiation of pluripotent and multipotent cells


Provided are cortical interneurons and other neuronal cells and in vitro methods for producing such cortical interneurons and other neuronal cells by the directed differentiation of stem cells and neuronal progenitor cells. The present disclosure relates to novel methods of in vitro differentiation of stem cells and neural progenitor cells to produce several type neuronal cells and their precursor cells, including cortical interneurons, hypothalamic neurons and pre-optic cholinergic neurons.
Cornell University


04/28/16
20160115447 

Compositions and methods for improving induced neuron generation


The present inventions relate to methods and compositions useful for improving the efficiency of inducing the generation of neurons from non-neuronal cell types, for example, by contacting the cell or cell culture medium with one or more agents which inhibit activin and/or plk1 signaling. Also disclosed are methods for promoting neuron survival, for example, by inhibiting activin and/or plk1 signaling, and methods for promoting the survival of intermediates in a cell differentiation pathway, for example, by inhibiting activin and/or plk1 signaling..
President And Fellows Of Harvard College


04/28/16
20160115446 

Technologies, methods, and products of small molecule directed tissue and organ regeneration from human pluripotent stem cells


Pluripotent human embryonic stem cells (hescs) hold great potential for restoring tissue and organ function, which has been hindered by inefficiency and instability of generating desired cell types through multi-lineage differentiation. This instant invention is based on the discovery that pluripotent hescs maintained under defined culture conditions can be uniformly converted into a specific lineage by small molecule induction.
San Diego Regenerative Medicine Institute


04/28/16
20160115238 

Cd20 antibodies and uses thereof


Cd20 is a transmembrane protein of the tetra-spanin family expressed on the surface of b-cells from peripheral blood as well as lymphoid tissues. Cd20 expression persists from the early pre-b cell stage until the plasma cell differentiation stage.
Immunogen, Inc.


04/28/16
20160115167 

Bmp inhibitors and methods of use thereof


The present invention provides small molecule inhibitors of bmp signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
The General Hospital Corporation


04/28/16
20160113979 

Pharmaceutical composition for promoting bone tissue formation, containing stauntonia hexaphylla leaf extract as active ingredient


The present invention relates to a composition for promoting osteoblast or cartilage cell differentiation. More particularly, the present invention relates to a composition, which includes stauntonia hexaphylla leaf extract that may be safely used without toxicity and side effects by using a natural ingredient, for promoting bone (tissue) formation to be used for suppressing and treating bone and cartilage tissue damage.
Jeonnam Bioindustry Foundation


04/21/16
20160112071 

Multiband wireless data transmission between aircraft and ground systems based on availability of the ground systems


Provided are methods and systems for multiband wireless data transmission between aircraft and ground systems. The transmission uses different wavelength ranges, each wavelength range corresponding to a different data domain and establishing a different communication channel.

04/21/16
20160108366 

Method for inducing exocrine pancreatic cells


An object of the present invention is to provide a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells. The above object is achieved by providing a method for inducing the differentiation of pancreatic precursor cells into exocrine pancreatic cells using a culture solution containing a histone deacetylase inhibitor and/or a ligand protein for a notch signal, and a protein kinase c activator..

04/21/16
20160108362 

Culture medium and inducing differentiation of pluripotent stem cells into neuroepithelial cells


The present invention discloses a culture medium and method for inducing differentiation of pluripotent stem cells into neuroepithelial cells. The culture medium comprises at least two agents for neural induction, wherein the agents includes a wnt signal agonist and a smad2/3 inhibitor and the culture medium is a feeder free culture.

04/21/16
20160108126 

Cd20 antibodies and uses thereof


Cd20 is a transmembrane protein of the tetra-spanin family expressed on the surface of b-cells from peripheral blood as well as lymphoid tissues. Cd20 expression persists from the early pre-b cell stage until the plasma cell differentiation stage.

04/21/16
20160108118 

Anti-tnf-alpha/cxcl10 double-targeting antibody and use thereof


The present invention relates to a tnf-α (tumor necrosis factor-alpha)/cxcl-10 (c-x-c motif chemokine 10) double targeting antibody based on the igg format. Specifically, it was verified that an antibody, in which scfv having a heavy chain variable domain and a light chain variable domain of the cxcl10 specific antibody links to the c-terminus of the heavy chain constant domain of the tnf-α specific antibody, is a bispecific antibody that effectively binds to both tnf-α and cxcl10, and thus the antibody can be useful as a double targeting antibody capable of identifying tnf-α/cxcl10.

04/14/16
20160103864 

Structured information differentiation in naming


Structured information differentiation in naming techniques are described. In one or more embodiments, first and second collections of structured information are tokenized to generate a first ordered list of tokens that correspond to the first collection of structured information and a second ordered list of tokens that correspond to the second collection of structured information.

04/14/16
20160101156 

Composition containing palmultang extract for promoting proliferation of stem cells derived from bone marrow


The present invention relates to a composition for promoting the proliferation of stem cells derived from bone marrow using a palmultang extract, and more specifically, to a composition for promoting the proliferation of stern cells derived from bone marrow by administering a granulocyte colony-stimulating factor to a subject and then administering the palmultang extract to the subject. The composition of the present invention remarkably reduces side effects, such as enlargement of the spleen, which are caused by the administration of g-csf alone for proliferation and differentiation of the stern cells, through administration in combination with the palmultang extract, thereby further promoting the proliferation and differentiation of stem cells..

04/14/16
20160101042 

Composition comprising an extract of herbal medicine processed by an oriental herbal medicine processing


The present specification relates to a composition comprising processed ginseng extract and processed green tea extract. Such a composition results in having a synergistic effect due to mixing of each processed extract, and is thus capable of promoting the production of procollagen and inhibiting the expression of collagenase.

04/07/16
20160097096 

Composition for detecting undifferentiated human pluripotent stem cell, monoclonal antibody 6-1 and use thereof


The present invention relates to a composition for detecting the undifferentiated human pluripotent stem cells comprising an agent useful for measuring the level of desmoglein 2 (dsg 2) mrna or the protein thereof, a kit for detecting the undifferentiated human pluripotent stem cells comprising the said composition, a method for detecting the undifferentiated human pluripotent stem cells containing the step of measuring the level of desmoglein 2 mrna or the protein thereof, a method for evaluating the differentiation of human pluripotent stem cells and thereafter for separating the undifferentiated human pluripotent stem cells, a method for reducing the undifferentiated status of human pluripotent stem cells by inhibiting the expression or activation of desmoglein 2, and a monoclonal antibody binding specifically to human desmoglein 2.. .
Korea Research Institute Of Bioscience And Biotechnology


04/07/16
20160096868 

Mussel-inspired bioactive surface coating composition generating silica nanoparticles


The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.. .
Postech Academy-industry Foundation


04/07/16
20160095958 

Bone regeneration using stromal vascular fraction, platelet-derived growth factor-rich hydrogel, three-dimensional printed poly-epsilon-caprolactone scaffolds


The presently disclosed subject matter focuses on recapitulating the heterotypic interactions needed to maximize the co-development of vasculature and bone. More particularly, the presently disclosed subject matter explores the potential of cellular aggregation and temporal presentation of factors to induce the cell-cell signaling events required to stimulate ascs to self-organize into vascularized bone.
The Johns Hopkins University


04/07/16
20160095905 

Compositions and methods for induced brown fat differentiation


The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both prdm1β and c/ebpβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both prdm1β and c/ebpβ expression and/or activity.
Dana-farber Cancer Institute, Inc.


04/07/16
20160095815 

Substance for restoring normal co-expression and interaction between the lox and nrage proteins


The invention relates to the use of a substance for restoring normal co-expression and interaction between the lox and nrage proteins. The invention relates in particular to the use of an effective amount of at least one substance that modulates the expression and/or activity of the lox of seq id no: 1 and/or that modulates the expression and/or activity of the nrage of seq id no: 2 for modulating the interaction between the lox and nrage proteins to regulate the balance between the cellular proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between lox and nrage is absent or altered.
Université Claude Bernard Lyon 1


03/31/16
20160090638 

Methods of prognostically classifying and treating glandular cancers


This disclosure includes the identification of molecular markers, including aspm, atp9a, acox3, cd-c45l, slc40a1, agr2, and those found in table 2, that are associated with the differentiation and the clinical prognosis of pancreatic cancer. More specifically, the disclosure includes the identification of sets of gene markers whose expression levels can be used to distinguish pancreatic cancers with higher degrees of differentiation from those with lower degrees of differentiation.
National Health Research Institutes


03/31/16
20160089319 

Actives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin


A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin..
Elc Management Llc


03/24/16
20160085388 

Desktop environment differentiation in virtual desktops


Desktop environment differentiation in virtual desktop techniques are described. In one or more implementations, a user is logged into a corresponding single user account of an operating system of a computing device.
Microsoft Technology Licensing, Llc


03/24/16
20160084980 

Method and detecting and mapping subsurface anomalies


A method for estimating at least one geophysical property is disclosed. The method includes using a plurality of transmitter electrodes distributed in a conductive medium, periodically passing rectangular current impulses through the media; collecting a sequence of sounding data between each of the impulses with a receiver electrode disposed between the plurality, determining a first difference and a second difference of the electric potential between points of the collected data; when each of the transmitters is excited, acquiring a focused measurement by simultaneously calculating a combination of at least one orthogonally weighted measurement and at least one axially weighted measurement obtained by the receiver, wherein the weighting is obtained from a condition of equipotentiality in four outer electrodes of the receiver; and, applying a time-differentiation technique to obtain deep measurements that exhibit low noise contribution from shallow features.

03/24/16
20160084838 

Modulators of itch ubiquitinase activity


The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the e3 ubiquitin ligase, itch, as a means for treating disorders.
Ryboquin Company Limited


03/24/16
20160084832 

Method and device for combined detection of viral and bacterial infections


A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections.
Rapid Pathogen Screening, Inc.


03/24/16
20160083468 

Compositions comprising antibodies to lingo or fragments thereof


Endogenous lingo-1 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous lingo-1 function, such anti-lingo-1 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction.
Biogen Ma Inc.


03/24/16
20160083442 

Inhibitors of the t cell-specific alternative p38 activation pathway and methods of use


In t lymphocytes, p38 mitogen activated protein kinase (mapk) can be activated through an alternative pathway that involves phosphorylation at tyrosine 323. Disclosed herein is the identification of a minimal region of the growth arrest and dna damage-inducible alpha (gadd45α) protein that is required for binding to and inhibition of tyrosine 323-phosphorylated p38 in t cells.
The U.s.a, As Represented By The Secretary Department Of Health And Human Services


03/24/16
20160082079 

Wnt antagonist and methods of treatment and screening


The present invention relates to compositions comprising wnt antagonists and methods of treating wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such wnt antagonists. In particular, the invention discloses soluble fzd, sfrp and ror receptors and their use..
Oncomed Pharmaceuticals, Inc.


03/24/16
20160081973 

Activator of mitochondria


In order to allow differentiation induction of cancer cells into normal cells, the present invention provides an activator of mitochondria containing a component expected to have an epigenetic action, or provides a cell differentiation inducer having a novel composition that has an action to activate mitochondria. The activator of mitochondria contains, as an effective component, 0.03 to 300 μg/ml of a single component of kaempferol, or a mixture component of kaempferol and glycerol.
Flora Co., Ltd.


03/17/16
20160079791 

Energy harvesting apparatus and method


Disclosed is an energy harvesting apparatus. The energy harvesting apparatus includes a rectifier for rectifying an alternating current (ac) voltage supplied from an energy source into a direct current (dc) voltage, a charging unit for storing an output voltage of the rectifier, and a maximum power point tracker selectively connected between the rectifier and the charging unit, for differentiating the output voltage of the rectifier in a first connection state, and for controlling the output voltage of the rectifier based on a differentiation result..
Korea University Research And Business Foundation


03/17/16
20160075997 

Kit of medium of inducing and amplifying hematopoietic stem cells


A kit of medium of inducing and amplifying hematopoietic stem cells, the kit includes medium of inducing and amplifying hematopoietic stem cell, and the medium of inducing and amplifying hematopoietic stem cell includes cell proliferation factors and cell differentiation inhibitors needed in proliferation of hematopoietic stem cells, and the formula of the medium of inducing and amplifying hematopoietic stem cell is: 80-100% (v/v) dmem/f12 basic medium, 0-1 μg/ml sonic hedgehog, 0-1 μg/ml delta1, 0-1 μg/ml flt3l, 0-1 μg/ml igfbp, 0-1 μg/ml scf, 0-1 μg/ml, angiopoietin, 0-1 μg/ml tpo, 0-1 μg/ml mbp, 0-1 μg/ml lif, 0-1 μg/ml tgf-β, 0-100 mm mtepa, and 1-5 mm nac.. .
Beijing Ginkgo Bioscience Co., Ltd.


03/17/16
20160074471 

Use of human small leucine zipper protein in adipocyte differentiation procedure


The present invention relates to a use of a human small leucine zipper protein in the adipocyte differentiation procedure. More specifically, slzip binds with pparγ2 to induce the formation of a complex of hdac3 and pparγ2, thereby functioning as a corepressor to negatively inhibit the transcriptional activity of pparγ2 and suppress the differentiation to adipocytes, and thus can be used as a marker for treating diabetes and obesity and developing new medicines therefor..
Korea University Research And Business Foundation


03/17/16
20160074400 

Wnt modulators for the protection, mitigation and treatment of radiation injury


Provided are composition and methods for treating radiation-induced cell damage, and in particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced induced depletion of tissue stem cells and injury to the supportive stem cell niche, and in even more particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced gastrointestinal syndrome (rigs), comprising sequential administration of a wnt pathway activator/agonist (e.g., rspo1 or a small molecule inducer thereof) that amplifies the surviving intestinal stem cell (isc) pool post-radiation exposure, followed by a selective antagonist of the β-catenin-cbp interaction (e.g., icg-001 or other exemplary compounds disclosed herein) that accelerates differentiation of the stimulated (e.g., rspo1-stimulated) isc in crypt-villi axis, promoting villous regeneration and intestinal restitution, thereby mitigating rigs. Adjunctive and combination therapy embodiments are encompassed..
Albert Einstein College Of Medicine Of Yeshiva University


03/17/16
20160074338 

Food composition for preventing obesity, pharmaceutical composition for treating obesity, and animal medicine for treating obesity, containing gingernone a


Disclosed is a composition comprising gingerenone a as an active ingredient. The composition includes a food composition for preventing obesity, a pharmaceutical composition for treating obesity and a medicine for treating animal obesity.
Snu R&db Foundation


03/17/16
20160074277 

System and titrating in vivo cellular reaction and gene expression using varying oscillation frequencies


A system and method for directing vibrational oscillating sonic waves toward a target tissue in the body of a person, to thereby influence a phenotypic differentiation of the target tissue at a cellular level, requires the use of an epidermal or implantable patch. Mounted on the patch is a sonic generator for generating sonic energy that entrains cellular functions of the target tissue for a desired phenotypic response.
Strathspey Crown Holdings, Llc


03/10/16
20160072823 

Using multiple credentials for access and traffic differentiation


The disclosure relates in some aspects to establishing connectivity with a network using a first set of credentials and determining whether additional connectivity needs to be established (e.g., using a second set of credentials) to communicate data. The disclosure relates in some aspects to the use of multiple credentials for access and service connectivity.
Qualcomm Incorporated


03/10/16
20160069882 

Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis


The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases.
Albert-ludwigs-universitÄt Freiburg


03/10/16
20160069868 

Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrosis


The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic diseases, in particular diseases related to fibroblast migration and differentiation. The invention provides polypeptide and nucleic acid targets, sirna sequences based on these targets and antibodies against the targets.
Galapagos Nv


03/10/16
20160068908 

Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells


The invention relates to human homeobox transcription factor ventx and its regulation of differentiation and maturation of human dendritic cells, and related therapeutic and diagnostic compositions and methods of use.. .

03/10/16
20160068814 

Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells


Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, by, for example, inhibiting gsk-3 to obtain a first population of cells.
Wisconsin Alumni Research Foundation


03/10/16
20160068813 

Differentiation of adipose stromal cells into osteoblasts and uses thereof


The invention further provides methods of identifying compounds that affect osteoblast differentiation. Such compounds are useful in the study of bone development and in the treatment of bone disorders, including bone fractures and osteoporosis..

03/10/16
20160068806 

Compositions and methods for precise patterning of posterior neuroectoderm from human pluripotent stem cells


Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells into caudal lateral epiblasts, posterior neuroectoderm or posterior neuroepithelium, or motor neurons having specified hox gene expression pattern mirroring a desired position along the rostral-caudal axis during hindbrain and spinal cord development. Also described are isolated populations of cells including caudal lateral epiblasts, posterior neuroectoderm, posterior neuroepithelium, or motor neurons having a hox gene expression pattern specified to correspond to the hox gene expression pattern associated with a desired rostral-caudal axis position..
Wisconsin Alumni Research Foundation


03/10/16
20160068525 

Fused heterocyclic compounds as selective bmp inhibitors


The present invention provides small molecule inhibitors of bmp signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation..
Vanderbilt University


03/10/16
20160067308 

Use of human small leucine zipper protein in osteogenesis procedure


The present invention relates to a use of a human small leucine zipper protein in the osteogenesis procedure. More specifically, slzip increases the transcriptional activity of runx2 and inhibits the transcriptional activity of pparγ2, thereby increasing the osteoblast differentiation, so that slzip performs an important role in the osteogenesis procedure, and thus can be used as a marker for treating bone disease and developing new medicines..
Korea University Research And Business Foundation


03/10/16
20160067270 

Use of ginsenoside f2 for prophylaxis and treatment of liver disease


Provided are use of ginsenoside f2 in the prevention, improvement or treatment of liver disease, and a pharmaceutical composition, a health functional food, and a feed composition including ginsenoside f2. Ginsenoside f2 inhibits fat synthesis and accumulation in the liver, and increases distribution of regulatory t cells capable of inhibiting activity of inflammatory cells, thereby preventing hepatitis, and also increases expression of anti-inflammatory cytokine il-10 in regulatory t cells, and inhibits differentiation of naive t cells into th17 cells, and is thereby effectively used for the treatment of various liver diseases..
Intelligent Synthetic Biology Center


03/10/16
20160067213 

Combination treatment of cardiovascular disease


Disclosed are methods, compositions of matter and cells for treatment of cardiovascular disease through concurrent inhibition of oxidative stress while administration of a cell therapy. The invention also concerts the modulation of oxidative stress for preferential induction of differentiation while concurrently inhibiting inflammatory processes that decrease efficacy of cellular therapy..
Creative Medical Health Inc.


03/03/16
20160060600 

Method for inducing hemoblast differentiation


The present invention relates to the in vitro production of erythrocytes/granulocytes and to the treatment of myelodysplastic syndrome using a method for inducing hemoblast differentiation. The present invention provides a media composition comprising gelsolin as an active ingredient for inducing the differentiation of hematopoietic precursor cells into erythrocytes/granulocytes, and a pharmaceutical composition comprising gelsolin as an active ingredient for treating myelodysplastic syndrome.
Industry-university Cooperation Foundation Hanyang


03/03/16
20160060595 

Methods and media for differentiating eye cells


Here is provided a novel differentiation protocol, which was experimentally shown to give rise to corneal epithelial precursor cells or early pigmented rpe precursor cells in defined and xeno-free conditions. The early precursor cells may be further maturated towards corneal epithelium cells, stratified corneal epithelium or mature rpe cells.
Tampereen Yliopisto


03/03/16
20160060319 

Development of protein-based biotherapeutics that induced osteogenesis for bone healing therapy: cell-permeable bmp2 and bmp7 recombinant proteins (cp-bmp2 & cp-bmp7), polynucleotides encoding the same and pro-osteogenic compositions comprising the same


The present invention is about direct protein delivery system for bone morphogenetic proteins (bmps) to enhance bone regeneration without the need of additional delivery carrier which requires open surgery for their implantation. The cell-permeable bmp (cp-bmp) recombinant proteins are fused with advanced macromolecule transduction domain (amtd) to give them ability for cell penetration and with solubilization domain (sd) to increase their solubility and manufacturing yield.
Cellivery Therapeutics, Inc.


03/03/16
20160058910 

Method for preparing particulate decellularized tissue


A particulate decellularized tissue is provided which shows sufficiently effective tissue regeneration and does not show cytotoxicity when used as material for cell culture. In accordance with the method for preparing a particulate decellularized tissue comprising a step of applying a high hydrostatic pressure to animal-derived tissues in a medium, a particulate decellularized tissue is obtained which does not show cytotoxicity but shows the effect of cellular attraction and the effect of induction of cellular differentiation and shows a high effect of tissue regeneration..
Adeka Corporation


03/03/16
20160058810 

Composition containing angelica extract for promoting proliferation of stem cells derived from bone marrow


The present invention relates to a composition for promoting proliferation of bone marrow derived stem cells using an angelicae gigantis radix extract, and more particularly, to a composition which administers a granulocyte colony-stimulating factor into an object, and administers the angelicae gigantis radix extract to the object to promote the proliferation of the bone marrow derived stem cells. The composition of the present invention solves side effects such as splenomegaly which were caused by a method of administering only the g-csf for proliferation and differentiation of the stem cells, thereby significantly mitigating the side effects through co-administration of the angelicae gigantis radix extract, and further promoting the proliferation and the differentiation of the stem cells..
Comprehensive And Integrative Medicine Institute


03/03/16
20160058797 

Pharmaceutical composition and regenerating myofibers in the treatment of muscle injuries


A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages or injuries caused by an ischemic disease. The pharmaceutical composition contains an active ingredient compound with a backbone structure of formula (i).
Lead Billion Limited




Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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