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Differentiation patents



      

This page is updated frequently with new Differentiation-related patent applications.




Date/App# patent app List of recent Differentiation-related patents
04/07/16
20160097096 
 Composition for detecting undifferentiated human pluripotent stem cell, monoclonal antibody 6-1 and use thereof patent thumbnailComposition for detecting undifferentiated human pluripotent stem cell, monoclonal antibody 6-1 and use thereof
The present invention relates to a composition for detecting the undifferentiated human pluripotent stem cells comprising an agent useful for measuring the level of desmoglein 2 (dsg 2) mrna or the protein thereof, a kit for detecting the undifferentiated human pluripotent stem cells comprising the said composition, a method for detecting the undifferentiated human pluripotent stem cells containing the step of measuring the level of desmoglein 2 mrna or the protein thereof, a method for evaluating the differentiation of human pluripotent stem cells and thereafter for separating the undifferentiated human pluripotent stem cells, a method for reducing the undifferentiated status of human pluripotent stem cells by inhibiting the expression or activation of desmoglein 2, and a monoclonal antibody binding specifically to human desmoglein 2.. .
Korea Research Institute Of Bioscience And Biotechnology


04/07/16
20160096868 
 Mussel-inspired bioactive surface coating composition generating silica nanoparticles patent thumbnailMussel-inspired bioactive surface coating composition generating silica nanoparticles
The present invention relates to a fusion protein comprising a mussel adhesive protein and a silica-binding peptide linked to the mussel adhesive protein, a silica nanoparticle a silica connected to the fusion protein, a fusion protein-silica nanoparticle complex comprising the silica nanoparticle having bioactivity and adhesiveness for cell proliferation and accelerating the differentiation, a surface coating composition including the complex, its use, and a method of coating a surface using the surface coating composition.. .
Postech Academy-industry Foundation


04/07/16
20160095958 
 Bone regeneration using stromal vascular fraction, platelet-derived growth factor-rich hydrogel, three-dimensional printed poly-epsilon-caprolactone scaffolds patent thumbnailBone regeneration using stromal vascular fraction, platelet-derived growth factor-rich hydrogel, three-dimensional printed poly-epsilon-caprolactone scaffolds
The presently disclosed subject matter focuses on recapitulating the heterotypic interactions needed to maximize the co-development of vasculature and bone. More particularly, the presently disclosed subject matter explores the potential of cellular aggregation and temporal presentation of factors to induce the cell-cell signaling events required to stimulate ascs to self-organize into vascularized bone.
The Johns Hopkins University


04/07/16
20160095905 
 Compositions and methods for induced brown fat differentiation patent thumbnailCompositions and methods for induced brown fat differentiation
The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of both prdm1β and c/ebpβ activity and/or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of both prdm1β and c/ebpβ expression and/or activity.
Dana-farber Cancer Institute, Inc.


04/07/16
20160095815 
 Substance for restoring normal co-expression and interaction between the lox and nrage proteins patent thumbnailSubstance for restoring normal co-expression and interaction between the lox and nrage proteins
The invention relates to the use of a substance for restoring normal co-expression and interaction between the lox and nrage proteins. The invention relates in particular to the use of an effective amount of at least one substance that modulates the expression and/or activity of the lox of seq id no: 1 and/or that modulates the expression and/or activity of the nrage of seq id no: 2 for modulating the interaction between the lox and nrage proteins to regulate the balance between the cellular proliferation, differentiation and apoptosis, particularly in cases where the balance between these phenomena is disturbed, and especially in cases where the interaction between lox and nrage is absent or altered.
Université Claude Bernard Lyon 1


03/31/16
20160090638 
 Methods of prognostically classifying and treating glandular cancers patent thumbnailMethods of prognostically classifying and treating glandular cancers
This disclosure includes the identification of molecular markers, including aspm, atp9a, acox3, cd-c45l, slc40a1, agr2, and those found in table 2, that are associated with the differentiation and the clinical prognosis of pancreatic cancer. More specifically, the disclosure includes the identification of sets of gene markers whose expression levels can be used to distinguish pancreatic cancers with higher degrees of differentiation from those with lower degrees of differentiation.
National Health Research Institutes


03/31/16
20160089319 
 Actives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin patent thumbnailActives for stimulating differentiation of keratinocytes to lighten hyperpigmented skin
A method is provided for identifying a material having an efficacy for reducing color contrast between a hyperpigmented skin lesion and skin surrounding the hyperpigmented skin lesion without directly affecting melanocytes or melanogenesis. The method includes the steps of applying a composition containing a material to be tested to the hyperpigmented skin lesion; and after an interval of time, observing whether the composition has effected at least one of inhibiting proliferation of keratinocytes, stimulating differentiation of keratinocytes, and improving compressive deformation of dermal papillae, in a basal layer of epidermis in the hyperpigmented lesion of skin..
Elc Management Llc


03/24/16
20160085388 
 Desktop environment differentiation in virtual desktops patent thumbnailDesktop environment differentiation in virtual desktops
Desktop environment differentiation in virtual desktop techniques are described. In one or more implementations, a user is logged into a corresponding single user account of an operating system of a computing device.
Microsoft Technology Licensing, Llc


03/24/16
20160084980 
 Method and  detecting and mapping subsurface anomalies patent thumbnailMethod and detecting and mapping subsurface anomalies
A method for estimating at least one geophysical property is disclosed. The method includes using a plurality of transmitter electrodes distributed in a conductive medium, periodically passing rectangular current impulses through the media; collecting a sequence of sounding data between each of the impulses with a receiver electrode disposed between the plurality, determining a first difference and a second difference of the electric potential between points of the collected data; when each of the transmitters is excited, acquiring a focused measurement by simultaneously calculating a combination of at least one orthogonally weighted measurement and at least one axially weighted measurement obtained by the receiver, wherein the weighting is obtained from a condition of equipotentiality in four outer electrodes of the receiver; and, applying a time-differentiation technique to obtain deep measurements that exhibit low noise contribution from shallow features.

03/24/16
20160084838 
 Modulators of itch ubiquitinase activity patent thumbnailModulators of itch ubiquitinase activity
The present invention relates to the identification of new drug targets for therapy of disorders including cancer. In particular, the present invention relates to inhibition of the e3 ubiquitin ligase, itch, as a means for treating disorders.
Ryboquin Company Limited


03/24/16
20160084832 

Method and device for combined detection of viral and bacterial infections


A lateral flow assay is capable of detecting and differentiating viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections.
Rapid Pathogen Screening, Inc.


03/24/16
20160083468 

Compositions comprising antibodies to lingo or fragments thereof


Endogenous lingo-1 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous lingo-1 function, such anti-lingo-1 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction.
Biogen Ma Inc.


03/24/16
20160083442 

Inhibitors of the t cell-specific alternative p38 activation pathway and methods of use


In t lymphocytes, p38 mitogen activated protein kinase (mapk) can be activated through an alternative pathway that involves phosphorylation at tyrosine 323. Disclosed herein is the identification of a minimal region of the growth arrest and dna damage-inducible alpha (gadd45α) protein that is required for binding to and inhibition of tyrosine 323-phosphorylated p38 in t cells.
The U.s.a, As Represented By The Secretary Department Of Health And Human Services


03/24/16
20160082079 

Wnt antagonist and methods of treatment and screening


The present invention relates to compositions comprising wnt antagonists and methods of treating wnt-associated diseases and disorders, such as cancer, inducing differentiation, and reducing the frequency of cancer stem cells, as well as novel methods of screening for such wnt antagonists. In particular, the invention discloses soluble fzd, sfrp and ror receptors and their use..
Oncomed Pharmaceuticals, Inc.


03/24/16
20160081973 

Activator of mitochondria


In order to allow differentiation induction of cancer cells into normal cells, the present invention provides an activator of mitochondria containing a component expected to have an epigenetic action, or provides a cell differentiation inducer having a novel composition that has an action to activate mitochondria. The activator of mitochondria contains, as an effective component, 0.03 to 300 μg/ml of a single component of kaempferol, or a mixture component of kaempferol and glycerol.
Flora Co., Ltd.


03/17/16
20160079791 

Energy harvesting apparatus and method


Disclosed is an energy harvesting apparatus. The energy harvesting apparatus includes a rectifier for rectifying an alternating current (ac) voltage supplied from an energy source into a direct current (dc) voltage, a charging unit for storing an output voltage of the rectifier, and a maximum power point tracker selectively connected between the rectifier and the charging unit, for differentiating the output voltage of the rectifier in a first connection state, and for controlling the output voltage of the rectifier based on a differentiation result..
Korea University Research And Business Foundation


03/17/16
20160075997 

Kit of medium of inducing and amplifying hematopoietic stem cells


A kit of medium of inducing and amplifying hematopoietic stem cells, the kit includes medium of inducing and amplifying hematopoietic stem cell, and the medium of inducing and amplifying hematopoietic stem cell includes cell proliferation factors and cell differentiation inhibitors needed in proliferation of hematopoietic stem cells, and the formula of the medium of inducing and amplifying hematopoietic stem cell is: 80-100% (v/v) dmem/f12 basic medium, 0-1 μg/ml sonic hedgehog, 0-1 μg/ml delta1, 0-1 μg/ml flt3l, 0-1 μg/ml igfbp, 0-1 μg/ml scf, 0-1 μg/ml, angiopoietin, 0-1 μg/ml tpo, 0-1 μg/ml mbp, 0-1 μg/ml lif, 0-1 μg/ml tgf-β, 0-100 mm mtepa, and 1-5 mm nac.. .
Beijing Ginkgo Bioscience Co., Ltd.


03/17/16
20160074471 

Use of human small leucine zipper protein in adipocyte differentiation procedure


The present invention relates to a use of a human small leucine zipper protein in the adipocyte differentiation procedure. More specifically, slzip binds with pparγ2 to induce the formation of a complex of hdac3 and pparγ2, thereby functioning as a corepressor to negatively inhibit the transcriptional activity of pparγ2 and suppress the differentiation to adipocytes, and thus can be used as a marker for treating diabetes and obesity and developing new medicines therefor..
Korea University Research And Business Foundation


03/17/16
20160074400 

Wnt modulators for the protection, mitigation and treatment of radiation injury


Provided are composition and methods for treating radiation-induced cell damage, and in particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced induced depletion of tissue stem cells and injury to the supportive stem cell niche, and in even more particular aspects to methods for protecting, mitigating or otherwise treating radiation-induced gastrointestinal syndrome (rigs), comprising sequential administration of a wnt pathway activator/agonist (e.g., rspo1 or a small molecule inducer thereof) that amplifies the surviving intestinal stem cell (isc) pool post-radiation exposure, followed by a selective antagonist of the β-catenin-cbp interaction (e.g., icg-001 or other exemplary compounds disclosed herein) that accelerates differentiation of the stimulated (e.g., rspo1-stimulated) isc in crypt-villi axis, promoting villous regeneration and intestinal restitution, thereby mitigating rigs. Adjunctive and combination therapy embodiments are encompassed..
Albert Einstein College Of Medicine Of Yeshiva University


03/17/16
20160074338 

Food composition for preventing obesity, pharmaceutical composition for treating obesity, and animal medicine for treating obesity, containing gingernone a


Disclosed is a composition comprising gingerenone a as an active ingredient. The composition includes a food composition for preventing obesity, a pharmaceutical composition for treating obesity and a medicine for treating animal obesity.
Snu R&db Foundation


03/17/16
20160074277 

System and titrating in vivo cellular reaction and gene expression using varying oscillation frequencies


A system and method for directing vibrational oscillating sonic waves toward a target tissue in the body of a person, to thereby influence a phenotypic differentiation of the target tissue at a cellular level, requires the use of an epidermal or implantable patch. Mounted on the patch is a sonic generator for generating sonic energy that entrains cellular functions of the target tissue for a desired phenotypic response.
Strathspey Crown Holdings, Llc


03/10/16
20160072823 

Using multiple credentials for access and traffic differentiation


The disclosure relates in some aspects to establishing connectivity with a network using a first set of credentials and determining whether additional connectivity needs to be established (e.g., using a second set of credentials) to communicate data. The disclosure relates in some aspects to the use of multiple credentials for access and service connectivity.
Qualcomm Incorporated


03/10/16
20160069882 

Inhibitors of proteins specific for the secretome of a chondrocyte for use in the treatment of breast cancer metastasis


The present invention relates to a method for identifying inhibitors of breast cancer metastasis based on a screening with proteins that are specific for the secretome of a chondrocyte, preferably cytokines and/or chemokines. The ligands as identified lead to a decrease of the migration and/or a re-differentiation of a breast cancer cell and/or a reduction of the number and/or size of breast cancer metastases.
Albert-ludwigs-universitÄt Freiburg


03/10/16
20160069868 

Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrosis


The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic diseases, in particular diseases related to fibroblast migration and differentiation. The invention provides polypeptide and nucleic acid targets, sirna sequences based on these targets and antibodies against the targets.
Galapagos Nv


03/10/16
20160068908 

Homeobox transcription factor ventx regulates differentiation and maturation of human dendritic cells


The invention relates to human homeobox transcription factor ventx and its regulation of differentiation and maturation of human dendritic cells, and related therapeutic and diagnostic compositions and methods of use.. .

03/10/16
20160068814 

Chemically defined albumin-free conditions for cardiomyocyte differentiation of human pluripotent stem cells


Methods for generating high-yield, high-purity cardiomyocyte progenitors or cardiomyocytes from pluripotent cells are described. Wnt/β-catenin signaling is first activated in pluripotent cells, by, for example, inhibiting gsk-3 to obtain a first population of cells.
Wisconsin Alumni Research Foundation


03/10/16
20160068813 

Differentiation of adipose stromal cells into osteoblasts and uses thereof


The invention further provides methods of identifying compounds that affect osteoblast differentiation. Such compounds are useful in the study of bone development and in the treatment of bone disorders, including bone fractures and osteoporosis..

03/10/16
20160068806 

Compositions and methods for precise patterning of posterior neuroectoderm from human pluripotent stem cells


Described herein are methods, compositions, and kits for directed differentiation of human pluripotent stem cells into caudal lateral epiblasts, posterior neuroectoderm or posterior neuroepithelium, or motor neurons having specified hox gene expression pattern mirroring a desired position along the rostral-caudal axis during hindbrain and spinal cord development. Also described are isolated populations of cells including caudal lateral epiblasts, posterior neuroectoderm, posterior neuroepithelium, or motor neurons having a hox gene expression pattern specified to correspond to the hox gene expression pattern associated with a desired rostral-caudal axis position..
Wisconsin Alumni Research Foundation


03/10/16
20160068525 

Fused heterocyclic compounds as selective bmp inhibitors


The present invention provides small molecule inhibitors of bmp signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation..
Vanderbilt University


03/10/16
20160067308 

Use of human small leucine zipper protein in osteogenesis procedure


The present invention relates to a use of a human small leucine zipper protein in the osteogenesis procedure. More specifically, slzip increases the transcriptional activity of runx2 and inhibits the transcriptional activity of pparγ2, thereby increasing the osteoblast differentiation, so that slzip performs an important role in the osteogenesis procedure, and thus can be used as a marker for treating bone disease and developing new medicines..
Korea University Research And Business Foundation


03/10/16
20160067270 

Use of ginsenoside f2 for prophylaxis and treatment of liver disease


Provided are use of ginsenoside f2 in the prevention, improvement or treatment of liver disease, and a pharmaceutical composition, a health functional food, and a feed composition including ginsenoside f2. Ginsenoside f2 inhibits fat synthesis and accumulation in the liver, and increases distribution of regulatory t cells capable of inhibiting activity of inflammatory cells, thereby preventing hepatitis, and also increases expression of anti-inflammatory cytokine il-10 in regulatory t cells, and inhibits differentiation of naive t cells into th17 cells, and is thereby effectively used for the treatment of various liver diseases..
Intelligent Synthetic Biology Center


03/10/16
20160067213 

Combination treatment of cardiovascular disease


Disclosed are methods, compositions of matter and cells for treatment of cardiovascular disease through concurrent inhibition of oxidative stress while administration of a cell therapy. The invention also concerts the modulation of oxidative stress for preferential induction of differentiation while concurrently inhibiting inflammatory processes that decrease efficacy of cellular therapy..
Creative Medical Health Inc.


03/03/16
20160060600 

Method for inducing hemoblast differentiation


The present invention relates to the in vitro production of erythrocytes/granulocytes and to the treatment of myelodysplastic syndrome using a method for inducing hemoblast differentiation. The present invention provides a media composition comprising gelsolin as an active ingredient for inducing the differentiation of hematopoietic precursor cells into erythrocytes/granulocytes, and a pharmaceutical composition comprising gelsolin as an active ingredient for treating myelodysplastic syndrome.
Industry-university Cooperation Foundation Hanyang


03/03/16
20160060595 

Methods and media for differentiating eye cells


Here is provided a novel differentiation protocol, which was experimentally shown to give rise to corneal epithelial precursor cells or early pigmented rpe precursor cells in defined and xeno-free conditions. The early precursor cells may be further maturated towards corneal epithelium cells, stratified corneal epithelium or mature rpe cells.
Tampereen Yliopisto


03/03/16
20160060319 

Development of protein-based biotherapeutics that induced osteogenesis for bone healing therapy: cell-permeable bmp2 and bmp7 recombinant proteins (cp-bmp2 & cp-bmp7), polynucleotides encoding the same and pro-osteogenic compositions comprising the same


The present invention is about direct protein delivery system for bone morphogenetic proteins (bmps) to enhance bone regeneration without the need of additional delivery carrier which requires open surgery for their implantation. The cell-permeable bmp (cp-bmp) recombinant proteins are fused with advanced macromolecule transduction domain (amtd) to give them ability for cell penetration and with solubilization domain (sd) to increase their solubility and manufacturing yield.
Cellivery Therapeutics, Inc.


03/03/16
20160058910 

Method for preparing particulate decellularized tissue


A particulate decellularized tissue is provided which shows sufficiently effective tissue regeneration and does not show cytotoxicity when used as material for cell culture. In accordance with the method for preparing a particulate decellularized tissue comprising a step of applying a high hydrostatic pressure to animal-derived tissues in a medium, a particulate decellularized tissue is obtained which does not show cytotoxicity but shows the effect of cellular attraction and the effect of induction of cellular differentiation and shows a high effect of tissue regeneration..
Adeka Corporation


03/03/16
20160058810 

Composition containing angelica extract for promoting proliferation of stem cells derived from bone marrow


The present invention relates to a composition for promoting proliferation of bone marrow derived stem cells using an angelicae gigantis radix extract, and more particularly, to a composition which administers a granulocyte colony-stimulating factor into an object, and administers the angelicae gigantis radix extract to the object to promote the proliferation of the bone marrow derived stem cells. The composition of the present invention solves side effects such as splenomegaly which were caused by a method of administering only the g-csf for proliferation and differentiation of the stem cells, thereby significantly mitigating the side effects through co-administration of the angelicae gigantis radix extract, and further promoting the proliferation and the differentiation of the stem cells..
Comprehensive And Integrative Medicine Institute


03/03/16
20160058797 

Pharmaceutical composition and regenerating myofibers in the treatment of muscle injuries


A pharmaceutical composition and method for regenerating cardiomyocytes in treating or repairing heart muscle damages or injuries caused by an ischemic disease. The pharmaceutical composition contains an active ingredient compound with a backbone structure of formula (i).
Lead Billion Limited


02/25/16
20160056610 

Light emitting device


Light with a short pulse width is emitted using a simple structure. A light source 101, a differentiation circuit 102, and a switch 103 are connected in series.
Kabushiki Kaisha Topcon


02/25/16
20160056609 

Method for adjusting light emitting device


Light with a short pulse width is emitted using a simple structure. A light source 101, a differentiation circuit 102, and a switch 103 are connected in series.
Kabushiki Kaisha Topcon


02/25/16
20160054304 

Molecular targets and compounds, and methods to identify the same, useful in the treatment of fibrotic diseases


The present invention relates to methods and assays for identifying agents useful in the treatment of fibrotic conditions. The invention provides polypeptide and nucleic acid targets, sirna sequences based on these targets and antibodies against the targets.
Galapagos Nv


02/25/16
20160053363 

Nanoparticle differentiation device


A nanoparticle differentiation device 1 includes: a plurality of chambers 9 that are linearly arranged, and divided from each other by partitions 5; a generation chamber 2 that is provided with a material 4 to be vaporized; a plurality of film forming chambers 3a to 3c that are provided with respective substrates 7 on which nanoparticles 8a to 8c generated from the material 4 are film-formed; a plurality of communication tubes 6 that are provided to penetrate the respective partitions 5 in order to cause the adjoining chambers 9 to communicate with each other; a gas introducing tube 10 that communicates with the generation chamber 2 in order to introduce cooling gas; and a vacuum tube 14 that communicates with a high vacuum chamber 13 that is a chamber 9 arranged at a position farthest from the generation chamber 2, i.e., the film forming chamber 3c, among the chambers 9 in order to perform evacuation.. .
Kabushiki Kaisha Atsumitec


02/25/16
20160053315 

Method for differentiation of polynucleotide strands


Objective of the present invention is to provide a method for keeping of directional information in double-stranded dna. We suggest to convert polynucleotide into a hybrid double-stranded dna.
Max-planck-gesellschaft Zur Forderung Der Wissenschaften E.v.


02/25/16
20160053313 

Differentiation of macromolecules and analysis of their internal content in solid-state nanopore devices


Provided are solid-state nanopore platforms for fast, electronic, label-free and high-resolution analysis of biomolecules.. .
The Trustees Of The University Of Pennsylvania


02/25/16
20160053258 

Composition for controlling stem cells pluripotency, containing lin28a methylation inhibitor, and screening for lin28a methylation inhibitor


Provided is a composition for controlling pluripotency of stem cells including an lin28a methylation inhibitor and a screening method of the lin28a methylation inhibitor, and more particularly, a composition for controlling pluripotency of stem cells including an inhibitor controlling methylation of 135th lysine of lin28a that is methylated by set7/9, or a composition for treating cancer, and a screening method of the inhibitor, wherein the screening method includes (a) contacting a candidate material with a cell, the cell having a gene introduced thereinto; (b) measuring a methylation level of the 135th lysine of the lin28a; and (c) selecting an inhibitor controlling methylation of the 135th lysine of the lin28a. That is, the present invention relates to a composition for controlling pluripotency of embryonic stem cells, or an anti-cancer composition, and a screening method of the inhibitor.
Korea Advanced Institute Of Science And Technology


02/25/16
20160053230 

Culture medium and inducing differentiation of pluripotent stem cells to hepatoblasts


Provided are a method of inducing differentiation of pluripotent stem cells, such as induced pluripotent stem cells (hereinafter abbreviated as ips cells), to hepatocytes in a short period of time, and a substance to be used in the method. Specifically, provided are a method of producing a cell culture formed substantially of hepatoblasts, the method including culturing pluripotent stem cells, such as ips cells, in a culture medium having a composition shown in table 1 below, and a culture medium for inducing differentiation of pluripotent stem cells into hepatoblasts, which has a composition shown in table 1 below..
National University Corporation Chiba University


02/25/16
20160053227 

Agent for inducing differentiation of white adipocytes into brown-like adipocytes


This invention relates to an agent for inducing differentiation of white adipocytes into brown-like adipocytes comprising a compound which is a cyclization reaction product of a hydroxystilbene and which is represented by formula (1): (wherein each of r1 to r8 is a hydrogen atom, a hydroxyl group, a saturated or unsaturated, straight or branched alkoxy group having 1 to 10 carbon atoms, or a saturated or unsaturated, straight or branched alkyl group having 1 to 10 carbon atoms, and r1 to r8 may be same or different), or a pharmaceutically acceptable salt thereof.. .
Uha Mikakuto Co., Ltd.


02/25/16
20160053223 

Methods and compositions for affecting the differentiation of clostridia in culture


The invention relates generally to methods and compositions for maintaining and manipulating microbial cultures of gram-positive bacteria. Also provided are methods for identifying quorum sensing regulatory proteins and auto-inducing peptides in gram-positive bacteria.

02/25/16
20160053217 

Automatic stimulator for cell cultures based on vibrations


The present invention relates to an automatic stimulator based on vibrations for cell cultures, fulfilling the function of activating the proliferation of osteoprogenitor cells and of activating the expression of the genes involved in the process of cell differentiation toward the osteogenic line. This effect is produced in the cells by the application of mechanical vibrational load.
Universidad Militar Nueva Granada


02/25/16
20160051731 

Hybrid gel comprising particulate decellularized tissue


A hybrid gel comprising a particulate decellularized tissue (obtained by pulverizing animal-derived biological tissues that are decellularized (decellularized biological tissues)), fibrinogen and thrombin; a cell culture material comprising the hybrid gel; a method for preparing the hybrid gel; and a kit comprising a particulate decellularized tissue and a biological tissue adhesive are provided. The hybrid gel of the present invention exerts the effect to promote differentiation and gain of function of stem cells and the therapeutic effect to a variety of diseases..
Adeka Corporation


02/25/16
20160051592 

Methods of treating diseases with human trophoblast stem cells


Existence of human trophoblast stem (hts) cells has been suspected but unproved. The isolation of hts cells is reported in the early stage of chorionic villi by expressions of fgf4, fgfr-2, oct4, thy-1, and stage-specific embryonic antigens distributed in different compartments of the cell.
Accelerated Biosciences Corporation


02/25/16
20160051589 

Multipotent postnatal stem cells from human periodontal ligament and uses thereof


The invention generally relates to postnatal periodontal ligament stem cells and methods for their use. More specifically, the invention relates in one aspect to postnatal periodontal ligament multipotent stem cells, use of the cells to generate periodontium, differentiation of the cells and methods of tissue cryopreservation..
The United States Of America, As Represented By The Secretary, Department Of Health And Human


02/25/16
20160051558 

Pharmaceutical composition for inhibiting immune response through inducing differentiation into regulator t cells and promoting proliferation of regulator t cells


The present invention relates to new medical use of (tetrahydropyran-4-yl)-[2-phenyl-5-(1,1-dioxo-thiomorpholine-4-yl)methyl-1h-indol-7-yl]amine, and more particularly, to a pharmaceutical composition containing the compound as an active ingredient, which is used for inhibiting an immune response, and/or for inducing differentiation into regulator t cells from undifferentiated t cells and/or promoting proliferation of regulator t cells.. .
Lg Life Sciences Ltd.


02/18/16
20160048983 

Method and system for substantially reducing cone beam artifacts based upon image domain differentiation in circular computer tomography (ct)


Cone beam artifacts arise in circular ct reconstruction. The cone beam artifacts are substantially removed by reconstructing a reference image from measured data at circular source trajectory, differentiating the reference image; generating synthetic data by forward projection of the differentiated reference image along a pre-determined source trajectory, which supplements the circular source trajectory to a theoretically complete trajectory, reconstructing a correction image from the synthetic data and optionally applying a scaling factor.
Kabushiki Kaisha Toshiba


02/18/16
20160046910 

Tolerogenic dendritic cells, their production and uses therof


The present invention relates to a tolerogenic dendritic cell population (tr-dc) capable of generating a population of t cells having regulatory activity, method of production and uses thereof. Furthermore, soluble hla-g promotes the differentiation of a population of t cells with regulatory activity..
Fondazione Telethon


02/18/16
20160046908 

Methods for in vitro memory b cell differentiation and transduction with vsv-g pseudotyped viral vectors


The present disclosure relates to the in vitro differentiation of memory b cells to plasmablasts or plasma cells and genetic modification of these cells to express a protein of interest, such as a specific antibody or other protein therapeutic.. .
Immusoft Corporation


02/18/16
20160046905 

Pluripotent stem cell for neuronal differentiation induction


(2) maintaining expression of the lhx3, ngn2, and isl1 for three days or more.. .

02/18/16
20160046904 

Method for culturing hepatoblast-like cells and culture product thereof


Provided is a method of stably maintaining and culturing “hepatoblast-like cells” generated during a differentiation-inducing process from pluripotent stem cells to hepatocytes. The present invention also provides a culture product obtained by the culture method.
Osaka University


02/18/16
20160046761 

Biodegradable side chain liquid crystal elastomers: smart responsive scaffolds (srs) for tissue regeneration


Controlled biodegradable smart responsive scaffold (srs) materials enhance attachment and viability of cells, i.e. Actively guiding their expansion, proliferation and in some cases differentiation, while increasing their biomechanical functionality is an important key issue for tissue regeneration.
Kent State University


02/18/16
20160046710 

Notch2 binding molecules for treating respiratory diseases


The balance and distribution of epithelial cell types is required to maintain tissue homeostasis. In the lung, perturbations of this balance are hallmarks of human respiratory diseases, including goblet cell metaplasia and enhanced mucus secretion in asthma and chronic obstructive pulmonary disease.
Novartis Ag


02/18/16
20160046633 

Bmp inhibitors and methods of use thereof


The present invention provides small molecule inhibitors of bmp signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation.
The U.s.a., As Represented By The Secretary, Department Of Health & Human Services


02/18/16
20160045554 

Method for generating mature beta-like cells


The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes..
The University Of Western Australia


02/18/16
20160044871 

Plant cultivation method


To provide a technique whereby, in cultivating a crop, factors relating to differentiation into flower buds and leaf buds, sprouting, flowering, and fruiting, growth of young shoots, etc., are regulated. For example, the invention addresses the problem of regulating the growth of a crop so that the leaf buds sprout in tandem and with the sprouting of flower buds and flowering and fruiting are repeated under fresh foliage.
National University Corporation Tokyo University Of Agriculture And Technology


02/11/16
20160044559 

Method and transmitting handover request message in wireless communication system


A method and apparatus for transmitting a handover request message in a wireless communication system is provided. For service differentiation from a small cell and a macro cell, a first macro enodeb (enb) transmits a handover request message including a list of first services for a user equipment (ue), which are provided by the first macro enb, and a list of second services for the ue, which are provided by a small cell enb which has dual connectivity with the first macro enb..
Lg Electronics Inc.


02/11/16
20160041712 

Graphical object appearance-invariant signature


In one implementation, a plurality of signature vectors from a multi-dimensional representation of a graphical object is generated. Each of the signature vectors comprises attributes that vary little in response to changes in shape, size, orientation, and visual layer appearance of the graphical object, and each of the signature vectors includes attributes based on operations of integration, differentiation, and transforms on the multi-dimensional representation of the graphical object.
Hewlett Packard Development Corporation, L.p.


02/11/16
20160040976 

System and wide field oct imaging


Various embodiments of systems and methods are described herein for obtaining wide field oct images and other types of image data from at least one portion of a sample. Various embodiments of systems, and methods are described herein for assessing a degree of differentiation for a second region of an oct image of a tissue sample with respect to another first.
Perimeter Medical Imaging, Inc.


02/11/16
20160040130 

Differentiation of pluripotent stem cells


The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method utilizing a cyp26a inhibitor to produce a population of pancreatic endocrine precursor cells..
Janssen Biotech, Inc.


02/11/16
20160040129 

Conditionally immortalized long-term stem cells and methods of making and using such cells


Disclosed are methods for conditionally immortalizing stem cells, including adult and embryonic stem cells, the cells produced by such methods, therapeutic and laboratory or research methods of using such cells, and methods to identify compounds related to cell differentiation and development or to treat diseases, using such cells. A mouse model of acute myeloid leukemia (aml) and cells and methods related to such mouse model are also described..
The Regents Of The University Of Colorado


02/11/16
20160040126 

Regulation of differentiation into dopaminergic neurons by metalloprotease


The method and composition according to the invention can regulate the activity of adam17 and/or adam10 in neural stem cells or neural progenitor cells to increase dopaminergic neural cells in the midbrain area, and thereby providing the effect of treating diseases induced by the death of dopaminergic neural cells such as parkinson's disease. In addition, the method and composition according to the invention can inhibit the activity of adam17 and/or adam10, and thereby improving effect of treating diseases such as tumor.

02/11/16
20160040125 

A human blood-brain barrier model derived from stem cells


The present disclosure relates to a method for obtaining human brain-like endothelial cells by contacting a population of cells isolated from stem cells with a differentiation medium to obtain endothelial cells and co-culturing said endothelial cells with pericytes, with cells of the neurovascular unit or with a pericytes conditioned medium, to obtain brain-like endothelial cells. The present disclosure also relates to the use of the brain-like endothelial cells as an in vitro model of human blood-brain barrier and a kit for measuring blood-brain barrier permeability of a substance, comprising in vitro human endothelial cells..
University Of Artois


02/11/16
20160039905 

B7-h4 fusion proteins and methods of use thereof


Fusion proteins containing b7-ii4 polypeptides are disclosed. The b7-h4 fusion proteins can include full-length b7-h4 polypeptides, or can contain a fragment of a full-length b7-h4 polypeptide, including some or all of the extracellular domain of the b7-h4 polypeptide.
Amplimmune, Inc.


02/11/16
20160039397 

Method for determining the conditions of an underlying surface during unbraked or braked travel of a vehicle


A method for determining the conditions of an underlying surface during unbraked or braked travel of a vehicle by a wheel-specific characteristic variable which is derived from a change over time in the wheel speed detected at at least one vehicle wheel. According to invention there is provision that a) a jolt signal is formed by double differentiation of the wheel speed, b) in order to form the characteristic variable the difference between the absolute value of the jolt signal and a tolerance value is summed or integrated over time, and c) the condition of the underlying surface is determined by comparing the characteristic variable with an oscillation signal threshold value..
Continental Teves Ag & Co., Ohg


02/11/16
20160038641 

Compounds and matrices for use in bone growth and repair


Compositions of small molecules, matrices, and isolated cells including methods of preparation, and methods for differentiation, transdifferentiation, and proliferation of animal cells into the osteoblast blast cell lineage were described. Examples of osteogenic materials that were administered to cells or co-cultured with cells are represented by compounds of formula ii, iv, and vi independently or preferably in combination with a matrix to afford bone cells.
Human Biomolecular Research Institute


02/11/16
20160038546 

Factors extracted from fish embryos and use of mixtures thereof in the control of stem cell multiplication and differentiation


A cell growth and/or differentiation factor extracted from fish embryos in selected stages of stem cell differentiation, said stages being the mid-blastula-gastrula, tail bud and pharyngula stages. The invention also provides the use of growth and differentiation factors extracted from fish embryos in the control of stem cell multiplication and differentiation..

02/11/16
20160038545 

A isolating cells for therapy and prophylaxis


Disclosed are methods for isolating endothelial progenitor cells (epc). More particularly, the present invention discloses methods for isolating endothelial progenitor cells that exhibit self-renewal and differentiation capacity.
The University Of Queensland


02/11/16
20160038541 

Induced dendritic cells and uses thereof


The present invention relates to cells engineered to express at least one cytokine and at least one antigen which induces the self differentiation of dendritic cell (dc) progenitor cells into functional antigen-presenting induced dc (idc). Moreover, therapeutic uses of said idc for regenerating the immune system after transplantation of hematopoietic stem cells are disclosed.
Medizinische Hochschule Hannover


02/04/16
20160033359 

Edge propagating optical time domain reflectometer and using the same


An otdr system utilizes a laser source that is turned “on” and kept powered until its light reaches the end of the fiber span being measured (i.e., until the fiber span is fully illuminated). At any point in time after the fiber is fully illuminated, the laser source can be turned “off”.
Ii-vi Incorporated


02/04/16
20160032322 

Microvesicles


A method of producing a population of differentiated cells comprising: a) inducing differentiation in a first population of cells by applying an inducer to said cells, b) harvesting microvesicles produced from first population of cells, and c) inducing differentiation in a second population of cells by applying said microvesicles or a derivative thereof to said second population of cells wherein, said first population of cells is autologous to said second population of cells and wherein the inducer applied to said first population of cells is not present in said second population of cells or is only present in trace amounts. Also related methods of producing microvesicles, methods of medical and/or cosmetic treatment and related products and uses..
Lydac Neuroscience Limited


02/04/16
20160032250 

Differentiation of human embryonic stem cells


The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce cells expressing markers characteristic of the pancreatic endocrine lineage that co-express nkx6.1 and insulin and minimal amounts of glucagon..
Janssen Biotech, Inc.


02/04/16
20160032247 

Differentiation-inducing culture medium additive and use thereof


Provided is a differentiation-inducing culture medium additive for inducing bone differentiation of at least one type of cell selected from the group consisting of a stem cell, a dental pulp cell, a periodontal ligament cell, a placenta, an amnion, and a fibroblast under a serum-free condition, and a use of the differentiation-inducing culture medium additive. The differentiation-inducing culture medium additive of the present invention for inducing differentiation of a stem cell under a serum-free condition at least contains at least one growth factor selected from the group consisting of egf, fgf, and pdgf; dexamethasone; and β-glycerophosphate.
Two Cells Co., Ltd.


02/04/16
20160032244 

Method of inducing cellular differentiation using the notch3 receptor intracellular domain


The present invention relates to the intracellular domain of notch3 that can activate signaling and initiate transcription, thereby initiating cellular differentiation in general, and neuronal differentiation in particular. The present invention includes the use of polynucleotide sequences that code, entirely or partially, for the intracellular domain of notch3, for the purpose of inducing cellular differentiation.

02/04/16
20160032242 

A role for the perlman syndrome exonuclease dis3l2 in the lin28-let-7 pathway


The 3′-5′ exonuclease, dis3l2, is responsible for the decay of uridylated pre-let-7 mirna. Biochemical reconstitution assays revealed that 3′ oligouridylation stimulates dis3l2 activity in vitro, and knockdown of dis3l2 in mouse embryonic stem cells leads to the stabilization of pre-let-7 mirna.
Children's Medical Center Corporation


02/04/16
20160031837 

Compounds for inducing proliferation and differentiation of cells, and methods of use thereof


The present invention provides methods of inducing proliferation of and/or differentiating cells comprising contacting cells with compounds within the methods of the invention. The present invention further provides cells obtainable by the methods of the invention.
Massachusetts Institute Of Technology


02/04/16
20160030462 

Methods of manipulating the fate of cells


A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding rna species (cur), (b) a modified cur, or (c) a compound that modifies or affects cur, under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of rna:rna or rna:dna or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained.

02/04/16
20160030377 

Lipid compositions for the treatment of gastro-intestinal disorders and the promotion of intestinal development and maturation


The present invention provides a use of a lipid composition for the preparation of a nutritional, pharmaceutical or nutraceutical composition or a functional food, for the prevention and treatment of gastrointestinal diseases and disorders, and for promoting intestinal development, maturation, adaptation and differentiation.. .
Enzymotec Ltd.


01/28/16
20160024473 

Menstrual stems cells for the efficient support and expansion of cd34+ cd133+ hematopoietic stem cells in vitro


The invention relates to highly proliferative stem cell obtained from menstrual fluid. The menstrual stern cells (menscs) may be cultured in vitro and exhibit mesenchymal stem cell (msc)-like properties and some culture and expansion advantages.
Cells For Cells


01/28/16
20160024472 

Generation of dendritic cells from monocytic dendritic precursor cells with gm-csf in the absence of additional cytokines


The present invention it was determined that dendritic cells could be derived from various sources including peripheral blood monocytes in the presence of only gm-csf without other cytokines if the monocytes were not activated. By preventing activation, such as by preventing binding of the cells to the surface of the culture vessel, the monocytes do not require the presence of additional cytokines, such as il-4 or il-13, to prevent differentiation into a non-dendritic cell lineage.
Northwest Biotherapeutics, Inc.


01/28/16
20160024220 

Pharmaceutical composition comprising an anti-cd6 monoclonal antibody used in the diagnosis and treatment of rheumatoid arthritis


The present invention is related to the branch of immunology and particularly with the generation of pharmaceutical compositions containing a humanized monoclonal antibody recognizing the leukocyte differentiation antigen cd6. Accordingly with that statement, the purpose of this invention is to provide pharmaceutical compositions which contain a humanized anti-cd6 monoclonal antibody for the diagnosis and treatment of autoimmune diseases, particularly the rheumatoid arthritis..
Centro De Inmunologia Molecular


01/28/16
20160022865 

Aligned fiber and use thereof


A scaffold comprising an aligned fiber. The invention further relates to a scaffold comprising one or more electrospun fibers wherein a fast fourier transform (fft) analysis result of the fibers have adjacent major peaks with about 180? apart from each other.
Lifenet Health


01/28/16
20160022358 

Catheter with omni-directional optical lesion evaluation


A catheter is adapted to ablate tissue and provide lesion qualitative information on a real time basis, having an ablation tip section with a generally omni-directional light diffusion chamber with one openings to allow light energy in the chamber to radiate the tissue and return to the chamber. The chamber is irrigated at a positive pressure differential to continuously flush the opening with fluid.
Biosense Webster, Inc.




Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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