This page is updated frequently with new Differentiation-related patent applications.
| Methods and compositions for diagnosis and prognosis of renal injury and renal failure|
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of heat shock 70 kda protein 1, alpha-1-antitrypsin neutrophil elastase complex, stromelysin-1:metalloproteinase inhibitor 2 complex, 72 kda type iv collagenase:metalloproteinase inhibitor 2 complex, insulin-like growth factor 1 receptor, myeloid differentiation primary response protein myd88, neuronal cell adhesion molecule, and tumor necrosis factor ligand superfamily member 10 as diagnostic and prognostic biomarkers in renal injuries..
Astute Medical, Inc.
| Induced pluripotent stem cell model of noonan syndrome and use thereof|
The present invention relates to an induced pluripotent stem cell (ipsc) model of noonan syndrome, a preparation method thereof, and uses to study of the pathogenesis of noonan syndrome and a therapeutic agent screening method. Particularly, induced pluripotent stem cells from dermal fibroblasts of a noonan syndrome-patient (ns-ipscs) were generated, and differentiated into embryoid bodies (ebs), neural rosettes and neural cells.
Korea Advanced Institute Of Science And Technology
| Composition for promoting chondrocyte differentiation or treating cartilage diseases, containing klf10 expression inhibitor, and promoting cartilage differentiation by using same|
The present invention relates to a krueppel-like factor 10 (klf10) gene expression inhibitor promoting cartilage differentiation, and more specifically, to: a composition for promoting chondrocyte differentiation or treating cartilage diseases, containing a klf10 gene expression inhibitor promoting cartilage differentiation and inhibiting the hypertrophy and dedifferentiation of chondrocytes; a cell therapeutic agent containing the composition; a method for promoting cartilage differentiation in bone marrow stem cells, comprising a step of expressing the composition in bone marrow stem cells; and a method for screening a chondrocyte differentiation promoter or a chondrocyte therapeutic agent. The present invention first examined the generation inhibition mechanism of indian hedgehog (ihh) protein of which the molecular biological mechanism has not yet been clearly examined, and ascertained that chondrocyte differentiation is promoted and chondrocyte hypertrophy is inhibited when chondrocyte differentiation is induced by expressing the klf10 expression inhibitor in bone marrow stem cells.
Dongguk University Industry-academic Cooperation F Oundation
| Compositions and methods of treating t cell mediated disorder|
A method of generating a cd4+foxp3+ treg cell, the method includes administering at least one complement antagonist to a naive cd4+ t cell at an amount effective to substantially inhibits c3a receptor (c3ar) and/or c5a receptor (c5ar) signal transduction in the cd4+ t cell, induce tgf-β1 expression of the cd4+ t cell, and induce differentiation of the of the naive cd4+ t cell into a cd4+foxp3+ treg cell.. .
Case Western Reserve University
| Brain specific exosome based diagnostics and extracorporeal therapies|
Disclosed are methods, compositions, devices, and kits for the isolation of brain-specific exosomes. Specifically, methods, compositions, devices, and unbound kits comprising an isolated brain-specific extracellular vesicle or exosome joined to a first binding agent that is specific for tau, β-amyloid, sloo β, neuron-specific enolase, glycoprotein a2b5, cd133, nq01, synaptophysin, neuronal nuclei, mab 1569, polysialic acid-neural cell adhesion molecule (psa-ncam), or neurogenic differentiation 1 (neurod or beta2), or glycosylated or phosphorylated forms of these molecules, are provided..
Exosome Sciences, Inc.
|Gdf15 as biomarker for diagnosing mitochondrial diseases|
To obtain data associated with a mitochondrial disease, a method includes measuring the level of at least one protein selected from the group consisting of gdf15 (growth differentiation factor 15), hgf (hepatocyte growth factor), mig (gamma interferon induction monokine), scf (stem cell factor) and scgf-β (stem cell growth factor beta) in a biological sample collected from a subject. The measured protein level is compared to that of control subjects and then it is checked whether or not there is difference between the protein level of the subject and that of control subjects..
|Method for screening therapeutic and/or prophylactic agents for alzheimer's disease|
The present invention provides a method for screening a therapeutic and/or prophylactic agent for alzheimer's disease using at least one index selected from the levels of aβ oligomers, bip, cleaved caspase 4, prdx4 and ros in nerve cells or the like whose differentiation has been induced from ips cells derived from somatic cells of a patient with alzheimer's disease.. .
|Differentiation of human embryonic stem cells|
The present invention provides methods to promote the differentiation of pluripotent stem cells into insulin producing cells. In particular, the present invention provides a method to produce a population of cells, wherein greater than 80% of the cells in the population express markers characteristic of the definitive endoderm lineage..
Janssen Biotech, Inc.
|Downregulation of mir-7 for promotion of beta cell differentiation and insulin production|
A method of ex-vivo increasing insulin content in beta cells or stem cells is disclosed. The method comprising contacting the beta cells or stem cells with an agent for downregulating an activity or expression of mir-7, thereby increasing the insulin content in the beta cells or stem cells..
Yeda Research And Development Co. Ltd.
|Guided differentiation of induced pluripotent stem cells|
This document provides methods and materials related to making and using differentiated induced pluripotent stem cells. For example, methods and materials for making differentiated induced pluripotent stem cells (e.g., insulin-producing cells) that do not form cancer cells within a mammal (e.g., a human), cells that underwent guided differentiation from induced pluripotent stem cells, compositions containing cells that underwent guided differentiation from induced pluripotent stem cells, and methods for using cells that underwent guided differentiation from induced pluripotent stem cells (e.g., methods for using such cells to treat diabetes or to repair cardiovascular tissue) are provided..
Mayo Foundation For Medical Education And Research
Material for undifferentiated state-maintaining culture
A culture method (a preservation method) of somatic stem cells does not use a chemical such as dmso that affects a differentiation function of somatic stem cells. A material for an undifferentiated state-maintaining culture for a somatic stem cell, having a naturally occurring polysaccharide; a culture liquid in which the material for the undifferentiated state-maintaining culture is dispersed; a somatic stem cell-containing culture liquid in which the somatic stem cell is suspended in the culture liquid; and a culture method for mesenchymal stem cells in which a naturally occurring polysaccharide is used..
Low oxygen tension enhances endothelial fate of human pluripotent stem cells
Low oxygen tension is a critical regulator of the developing or regenerating vasculature. The present invention is based on the determination that low oxygen tension during early stages of early vascular cell (evc) derivation induces endothelial commitment and maturation of pluripotent stem cells.
The Johns Hopkins University
Method of differentiation from stem cells to hepatocytes
Disclosed are: a gene transduction method for use in the induction of the differentiation of stem cells such as es cells or ips cells into hepatocytes effectively; stem cells into each of which a gene useful for the induction of the differentiation into hepatocytes is introduced; and hepatocytes produced from stem cells each having the gene introduced therein. A specific gene can be introduced into stem cells such as es cells or ips cells using an adenovirus vector.
Japan Health Sciences Foundation
Postponed differentiation of reinforced composites
A reinforced composite is provided that includes at least one planar fiber reinforcement or fabric formed from a plurality of fibers. The fiber reinforcement or fabric has a first side and a second side.
Ocv Intellectual Capital, Llc
Subpopulations of spore-like cells and uses thereof
Subpopulations of spore-like cells expressing specific cell surface and gene expression markers are provided. In one embodiment, the cells express at least one cell surface or gene expression marker selected from the group consisting of oct4, nanog, zfp296, cripto, gdf3, utf1, ecat1, esg1, sox2, pax6, nestin, sca-1, cd29, cd34, cd90, b1 integrin, ckit, sp-c, cc10, sf1, dax1, and scg10.
Vbi Technologies, L.l.c.
Methods of using an activator of cereblon for neural cell expansion and the treatment of central nervous system disorders
Provided herein, for example, are methods generally relating to the expansion and/or regeneration of central nervous system (cns) cells, such as nerve cells, astrocytes and oligodendrocytes, using an activator of cereblon (crbn), such as an inhibitor of a crbn substrate or downstream protein. Also provided herein, for example, are methods related to the expansion of neural stem cells, neural progenitor cells, or neural precursor cells and/or differentiation of these cells into cns cells using a brd7 antagonist, ikaros antagonist, or crbn activator.
Intelligent touchscreen keyboard with finger differentiation
Implementations of the present disclosure include actions of displaying a plurality of keys on a touchscreen of a computing device, receiving user input to the touchscreen, the user input including a contact with the touchscreen, in response to receiving the user input, determining spatial information associated with the contact and generating an image of the contact, determining an output based on the image and the spatial information, and executing the output.. .
Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
The invention relates to assays for screening growth factors, adhesion molecules, immunostimulatory molecules, extracellular matrix components and other materials, alone or in combination, simultaneously or temporally, for the ability to induce directed differentiation of pluripotent and multipotent stem cells.. .
Advanced Cell Technology, Inc.
Integrated vibration measurement and analysis system
A vibration data collection system performs an integration or differentiation process on incoming digitized vibration data in real time. The system uses a digital infinite impulse response (iir) filter running at the input data rate to provide the integration or differentiation function.
Computational Systems, Inc.
Nanopore-facilitated single molecule detection of nucleic acids
The present invention provides a new and improved oligonucleotide detection method based on the nanopore technology with a probe containing a complementary sequence to the target oligonucleotide and a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini. The improved nanopore sensor with the probe enables sensitive, selective, and direct detection, differentiation and quantification of target oligonucleotides such as mirnas.
The Curators Of The University Of Missouri
Directed differentiation and maturation of pluripotent cells into hepatocyte like cells by modulation of wnt-signalling pathway
Provided are improved methods using glycogen synthase kinase 3 (gsk3) inhibitors by which endodermal cells, notable endodermal cells derived from human pluripotent stem cells (hps), such as but not limited to hips-cells and hes-cells may be differentiated into hepatocyte like cells. The specific modulation of wingless integration gene (wnt)-signalling pathway and use of gsk3 inhibitors achieve direct differentiation and maturation of hepatocytes derived from human pluripotent stem (hps) cells.
Takara Bio Europe Ab
Methods of generating natural killer cells
Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the nk cells produced by the method to an individual having the cancer or viral infection..
Master transcription factors identification and use thereof
Provided herein are methods for identifying master transcription factors (tfs) in a cell type of interest and for transdifferentiation of a somatic cell, e.g., a fibroblast to the cell type of interest. Also provided herein are induced retinal pigment epithelium (irpe) cell, master tfs therefor, methods for making irpe cell, and methods and compositions for treating an ocular disease such as age-related macular degeneration..
Whitehead Institute For Biomedical Research
Trans-differentiation of differentiation cells
The present invention comprises methods and compositions related to trans-differentiating differentiated cells, the methods comprising bringing said cells into contact with a polypeptide or a nucleic acid encoding said polypeptide.. .
Helmholtz Zentrum München-deutsches Forschungszent Forschungszentrum Für Gesundheit Und Umwelt (gmbh
A pentacyclic triterpenoid compound with modified structure and preparation method and use thereof
The present invention relates to new pentacyclic triterpenes, their preparation method and use. The compounds of the present invention could effectively treat psoriasis and selectively inhibit in vitro differentiation of the th1 and th17 cells, thereby could be used to treat the th1- or th17-mediated autoimmune diseases..
Suzhou Botany Biomedicals Co., Ltd
Method of producing gluten free oats
The separation of oats from a combination of grains is performed by obtaining optical data includes both reflectance data and visual data and then analyzing the data in multiple ways, including analyzing information obtained based on ratios of wavelengths and grain imagery. The reflectance data relies on near infrared spectroscopy at requisite ratios of wavelengths in the range of 1100 nm to 2200 nm, while the grain imagery encompasses images of both sides of each of the combination of grains and can also take into account grain size and shape differentiations.
General Mills, Inc.
Differentiation therapy with cd137 ligand agonists
There is disclosed a method of treating cancer comprising administering an agonist of cd137 ligand (cd137l) to a subject in need thereof.. .
National University Of Singapore
Brown adipocyte modification
Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss.
The General Hospital Corporation D/b/a Massachusetts General Hospital
Modulation of stem cell and progenitor cell differentiation, assays, and uses thereof
The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages.
Myeloid differentiation inducing agents
Myeloid differentiating agents can be used in the treatment of myeloid proliferative disorders.. .
Case Western Reserve University
Gel composition for treatment of common acne comprising a combination of benzoyl peroxide and adapalene and/or adapalene salt
Dermatological/cosmetic compositions suited for preventing or treating cell differentiation and/or proliferation and/or keratinization disorders, including preventing or treating common acne, comprise, in a physiologically acceptable medium, (i) at least one dispersed retinoid, (ii) dispersed benzoyl peroxide, in free or encapsulated form, and (iii) at least one ph-independent gelling agent, selected from the group consisting of (a) polyacrylamide gelling agents, (b) gelling agents which are acrylic polymers coupled to hydrophobic chains, (c) modified starch gelling agents, and mixture thereof, said composition maintaining good chemical stability of (i) and (ii) without their degradation over time at a temperature of between 4° c. And 40° c..
Galderma Research & Development
Composition containing fucosterol for skin whitening or moisturizing
The present invention relates to a novel use of fucosterol and, more specifically, to a composition for skin whitening or composition for skin moisturizing, which is characterized by containing fucosterol. Fucosterol of chemical formula 1 below has an excellent whitening effect of inhibiting melanin generation and tyrosinase activity, and thus can be used as an active ingredient of a cosmetic composition for whitening, a food composition, or a pharmaceutical composition.
Industry-academic Cooperation Foundation, Yonsei University
Spectrometry device, image forming device, and spectrometry method
A printer includes a spectroscope that has a variable wavelength interference filter which incidents light from a measurement region, and a light receiving section which receives light from the variable wavelength interference filter and which outputs a detection signal according to an amount of received light, a carriage moving unit which relatively moves the spectroscope along one direction with respect to a measurement target of spectrometry and moves the measurement region with respect to the measurement target, and a timing detection circuit which has a differential circuit that differentiates the detection signal and outputs a differentiation signal, wherein in a case where the measurement target is a color patch, spectrometry in which the amount of received light is detected starts based on the differential signal.. .
Seiko Epson Corporation
T cell balance gene expression, compositions of matters and methods of use thereof
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences t cell balance, for example, th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences t cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence t cell balance in a variety of therapeutic and/or diagnostic indications..
Massachusetts Institute Of Technology
Methods and detection of gluten sensitivity, and its differentiation from celiac disease
Antibodies are used as biomarkers to assist in distinguishing gluten immune reactivity and sensitivity, silent celiac disease, crohn's disease and other gut-related pathologies from classical celiac disease. In one class of embodiments, sera, saliva or other samples from a human or other animal are tested for antibodies to (a) a wheat antigen; (b) a gliadin antigen; and (c) one or more of a wheat germ agglutinin, a gluteomorphin, a glutenin, a deamidated glutenin, a prodynorphin, and a dynorphin.
Cyrex Laboratories, Llc
Defined three-dimensional microenvironment for stem cell
This disclosure provides for a three-dimensional (3d) microenvironment presenting defined physical or mechanical cues that regulate cellular behavior and use of the matrix. The disclosure also provides for devices and methods for screening for optimal combinations of physical and mechanical cues in order to create a microenvironment that can regulate specific cellular behavior such as cell growth, proliferation, migration or differentiation..
Konkuk University Industrial Cooperation Corp.
Methods of manipulating the fate of cells
A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding rna species (cur), (b) a modified cur, or (c) a compound that modifies or affects cur, under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of rna:rna or rna:dna or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained.
Method for inducing human cholangiocyte differentiation
The invention relates to a method for inducing human cholangiocyte differentiation of progenitor cells called hepatoblasts. More specifically, the invention relates to a method for differentiating hepatoblasts to cholangiocytes by culturing said hepatoblasts with a particular medium having interleukin-6 (il-6) activity.
Université Paris Descartes
Retention device for collectibles in plastic collectibles pages
An improved collectibles page for the storage and display of collectibles such as coins, sports cards, currency or business cards can be created by adding a flap to the front sheet of the page and corresponding slots to the back sheet of the page. These improvements allow for the retention of the collectibles within the collectibles page as well as providing an additional level of security against theft.
Method and improved schmidl-cox-based signal detection
Techniques are disclosed relating to detection of wireless signals. In some embodiments, a method includes generating an autocorrelation result for a training field in a received wireless message, generating differentiation information based on the autocorrelation result, and determining that one or more signal recognition criteria are met.
National Instruments Corporation
Assays and monitoring paradigms for stem cell culture
The invention provides, inter alia, methods for monitoring the differentiation state of cultured cells, such as cultured mscs, as well as related kits and systems for performing the methods. In certain embodiments, the methods entail measuring the level of one or more of klf5, fabp4, adiponectin/adipoq, chemerin/rarres2, klf4, pai1, runx2, alpl, osteocalcin/bglap, ctnnb1, osteonectin/sparc, sox9, col2a1, mia, and comp..
Merck Patent Gmbh
Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby
This invention generally relates to methods to differentiate pluripotent stem cells, such as embryonic stem, embryonic germ, or embryo-derived cells, to obtain subpopulations of cells from heterogeneous mixtures of cells wherein the subpopulation of cells possess reduced differentiation potential compared to the original pluripotent stem cells and where the subpopulation is capable of being propagated.. .
Advanced Cell Technology, Inc.
Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof
Compositions and methods that employ various combinations of such factors as retinoic acid signaling inhibitors, antioxidants, bmp4, vegf, prostaglandin e2 pathway stimulants, tpo, scf, flt-3, epo, tgfβ1, p38 mapk inhibitors, beta adrenergic receptor agonists, cell cycle inhibitors, rxr agonists, cripto, and chromatin remodelers to drive differentiation of pluripotent stem cells towards primitive blood cells. Uses of such primitive blood cells are provided..
Primorigen Biosciences, Inc.
Compositions comprising antibodies to lingo or fragments thereof
Endogenous lingo-1 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous lingo-1 function, such anti-lingo-1 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction.
Biogen Ma Inc.
Compounds and methods for treating cancers
Provided are carbazole and carbazole-like compounds (e.g., pyridoindole and pyrrolodipyridine compounds. The compounds can be used to selectively kill cancer cells.
Panacela Labs Llc
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