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Differentiation patents



      
           
This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS


Date/App# patent app List of recent Differentiation-related patents
10/23/14
20140316280
 Detection apparatus for determining a state of tissue patent thumbnailDetection apparatus for determining a state of tissue
The invention relates to a detection apparatus (30) for determining a state of tissue. The detection apparatus (30) comprises a fluorescence spectrum providing unit (2, 3) for providing a fluorescence spectrum of the tissue, a differentiation unit (4) for generating a derivative of the fluorescence spectrum, and a tissue state determination unit (5) for determining the state of the tissue from the derivative.
10/23/14
20140315988
 Compositions and methods for reprogramming eukaryotic cells patent thumbnailCompositions and methods for reprogramming eukaryotic cells
The present invention relates to methods for changing the state of differentiation of a eukaryotic cell, the methods comprising introducing mrna encoding one or more reprogramming factors into a cell and maintaining the cell under conditions wherein the cell is viable and the mrna that is introduced into the cell is expressed in sufficient amount and for sufficient time to generate a cell that exhibits a changed state of differentiation compared to the cell into which the mrna was introduced, and compositions therefor. For example, the present invention provides mrna molecules and methods for their use to reprogram human somatic cells into pluripotent stem cells..
10/23/14
20140315870
 Composition comprising a glucocorticoid and a thiazolidinedione for inducing compelte adipogenic differentiation of mammalian stem cells patent thumbnailComposition comprising a glucocorticoid and a thiazolidinedione for inducing compelte adipogenic differentiation of mammalian stem cells
The present invention relates to the provision of a composition comprising a glucocorticoid and a thiazolidinedione for inducing adipogenic differentiation, thereby successfully generating functional stem cells, from non-differentiated embryonic or adult stem cells originating from humans or other mammals, special preference being given to human mesenchymal stem cells. The preferred glucocorticoid is dexamethasone and the preferred thiazolidinedione is rosiglitazone.
10/23/14
20140315752
 Methods and compositions for diagnosis and prognosis of renal injury and renal failure patent thumbnailMethods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of stanniocalcin-1, antithrombin-iii, toll-like receptor 2, triiodothyronine (t3), thyroxine (t4), extracellular matrix protein 1, coagulation factor xiii a chain, coagulation factor xiii b chain, interleukin-17f, interleukin-22, vitronectin, progesterone, estradiol, growth/differentiation factor 15, and proprotein convertase subtilisin/kexin type 9 as diagnostic and prognostic biomarkers in renal injuries..
10/23/14
20140315306
 Cell culture substrate comprising a laminin and a cadherin patent thumbnailCell culture substrate comprising a laminin and a cadherin
The present disclosure related to isolated laminin-521, methods for making recombinant laminin-521, host cells that express recombinant laminin-521, and compositions containing laminin-521. Laminin-521 can maintain stem cells in vitro pluripotency, enable self-renewal, and enable single cell survival of human embryonic stem cells.
10/23/14
20140315305
 Method for producing corneal endothelial cell patent thumbnailMethod for producing corneal endothelial cell
The invention provides a method of efficiently producing corneal endothelial cells, particularly from corneal stroma or ips cell-derived neural crest stem cells, a method of producing corneal endothelial cells stably in a large amount by inducing more efficient differentiation of stem cells into corneal endothelial cells, and a medicament containing corneal endothelial cells. The method of inducing differentiation of stem cells into corneal endothelial cells includes a step of culturing the stem cells in a differentiation induction medium containing a gsk3 inhibitor (preferably a gsk3β inhibitor) and retinoic acid, with the differentiation induction medium preferably further containing one or more of tgfb2, insulin, a rock inhibitor, and the like..
10/23/14
20140315196
 Dna diagnostic screening for turner syndrome and sex chromosome disorders patent thumbnailDna diagnostic screening for turner syndrome and sex chromosome disorders
The present invention encompasses methods, assays and kits for the diagnosis, screening and identification of turner syndrome and other disorders of sexual differentiation in a human using single nucleotide polymorphisms present on the x and y chromosomes.. .
10/23/14
20140313895
 Femto cell access point passthrough model patent thumbnailFemto cell access point passthrough model
Fixed, differentiated quality of service (qos) is supplied for packetized traffic (e.g., voice and data) intended for femto cell coverage when transmitted concurrently with external broadband traffic. Quality of service differentiation is supplied without an external implementation.
10/16/14
20140309264
 Acylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals patent thumbnailAcylamino-substituted fused cyclopentanecarboxylic acid derivatives and their use as pharmaceuticals
Wherein a, y, z, r3 to r6, r20 to r22 and r50 have the meanings indicated in the claims, which are valuable pharmaceutical active compounds. Specifically, they are inhibitors of the endothelial differentiation gene receptor 2 (edg-2, edg2), which is activated by lysophosphatidic acid (lpa) and is also termed as lpa1 receptor, and are useful for the treatment of diseases such as atherosclerosis, myocardial infarction and heart failure, for example.
10/16/14
20140309131
 Method for screening induced pluripotent stem cells patent thumbnailMethod for screening induced pluripotent stem cells
The present invention provides a method for screening for ips cells exhibiting differentiation resistance using a marker identified as lincrna or mrna that is specifically expressed in an ips cell line exhibiting differentiation resistance, and such markers.. .
10/16/14
20140309129
Encoded nanopore sensor for multiplex nucleic acids detection
The present invention provides a new and improved multiplexed oligonucleotide detection method based on the nanopore technology with one or more probes containing a sequence with complementarity to the target oligonucleotide, a terminal extension at the probe's 3′ terminus, 5′ terminus, or both termini and a label attached to the terminus. The improved probes and probe sets enable sensitive, selective, and direct multiplex detection, differentiation and quantification of distinct target oligonucleotides such as mirnas.
10/16/14
20140308687
Method and use of metabolites for the diagnosis and differentiation of neonatal encephalopathy
Metabolites and signatures (panels) of metabolites are applicable as biomarkers in clinical diagnosis, in particular for neonatal encephalopathy. They are useful tools in differential clinical diagnosis for early detection of brain injury, determination of brain areas affected by the insults and prediction of adverse neurological outcome and may also be applied in diagnosing disease progression and treatment effect.
10/16/14
20140307255
Multi-surface scattered radiation differentiation
An optical inspector includes a radiating source, a time varying beam reflector, a telecentric scan lens, a first and second waveplate, a polarizing beam splitter, a first detector, a focusing lens, a blocker, and a second detector. The radiating source irradiates the first waveplate generating circularly polarized source beam that irradiates a first position of on the time varying beam reflector with a source beam.
10/09/14
20140302491
Ex vivo culture, proliferation and expansion of primary tissue organoids
Culture systems and methods for long term culture of mammalian tissues are provided. Tissues include but are not limited to lung alveolar tissue, stomach tissue, pancreas tissue, bladder tissue, liver tissue, and kidney tissue.
10/09/14
20140302112
Bone matrix compositions and methods
Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosis-inducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity.
10/09/14
20140302111
Compositions and methods for dental tissue regeneration
Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing wnt3a and bmp-7, and optionally vegf, bfgf, or ngf, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and wnt3a and bmp-7, and optionally vegf, bfgf, or ngf..
10/09/14
20140302059
Compositions and methods for cancer and cancer stem cell detection and elimination
In alternative embodiments, the invention provides compositions and methods for inhibiting or ablating cancer stem cells. In alternative embodiments, the invention provides compositions and methods for inhibiting the action of double-stranded rna-specific adenosine deaminases, or adar, enzymes.
10/09/14
20140301528
Color x-ray histology for multi-stained biologic sample
Systems and methods are provided for staining tissue with multiple biologically specific heavy metal stains and then performing x-ray imaging, either in projection or tomography modes, using either a plurality of illumination energies or an energy sensitive detection scheme. The resulting energy-weighted measurements can then be used to decompose the resulting images into quantitative images of the distribution of stains.
10/02/14
20140298450
Leveraging biometrics for authentication and touch differentiation
Biometric authentication and touch differentiation embodiments are described which use a handheld mobile computing device having a signal injection site that injects a signal into a user's hand for a prescribed period of time, and at least one signal sensing site each of which captures a signal emanating from a finger of either of the user's hands that is touching the signal sensing site during at least the period of time the signal is injected. The captured signal or signals are analyzed to determine whether they match, to a prescribed degree, a pre-established signal model that is indicative of a signal or signals expected to be captured.
10/02/14
20140296153
Oligodendrocyte differentiation
The present invention provides compounds, compositions and methods for treatment and/or prevention of neurodegenerative diseases, including but not limited to autoimmune diseases, such as multiple sclerosis, in which demyelination, (the loss of the myelin sheath that insulates the nerves) is an associated or causative feature. The data provided demonstrate the utility of the compounds and compositions according to this invention to promote oligodendrogenesis and myelination or remyelination..
10/02/14
20140296110
Optimized probes and primers and methods of using same for the binding, detection, differentiation, isolation and sequencing of influenza a; influenza b; 2009 influenza a/h1n1; and a 2009 influenza a/h1n1 rna sequence mutation associated with oseltamivir resistance
Described herein are primers and probes useful for the binding, detecting, differentiating, isolating, and sequencing of influenza a, influenza b, 2009 influenza a/h1n1, and a 2009 influenza a/h1n1 rna sequence mutation associated with oseltamivir resistance.. .
10/02/14
20140295552
Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
The present invention provides methods of preparing aggregated pluripotent stem cell clusters for differentiation. Specifically, the invention discloses methods of differentiating pluripotent cells into beta cell, cardiac cell and neuronal cell lineages using suspension clustering.
10/02/14
20140295551
Protein markers associated bone marrow stem cell differentiation into early progentior cells
A novel cytosolic 58 kd phosphoprotein induced during bone marrow stem cell (bm) differentiation into dendritic cells (dc) during in vitro cultivation with the cytokine gm-csf by addition of antisera to an 82 kd bm cell surface protein generating cultivatable dendritic progenitor cells (dp). Genes, methods for preparing them as well as early dp have been provided.
10/02/14
20140290656
Method and device for carrying out a signal-processing viewing of a measurement signal that is correlated to the respiratory activity of an individual
The invention relates to a method and device for carrying out a signal-processing viewing of a measurement signal that is correlated with the respiratory activity of an individual, for example, of a measurement signal that is correlated with the respiratory gas. The aim of the invention is to provide solutions with which an improved electronic analysis of the signals that are representative with regard to respiratory activity can be achieved.
09/25/14
20140288925
Bandwidth extension of audio signals
Audio decoder and method therein for supporting bandwidth extension (bwe) of a received signal. The method involves receiving a first signal representing the lower frequency spectrum of a segment of an original audio signal; receiving a second signal, being a bwe signal, representing a higher frequency spectrum of the segment of the original audio signal.
09/25/14
20140288178
Inhibition of c-myc ubiquitination to prevent cancer initiation and progression
The present invention is directed to methods of inhibiting cancer cell proliferation, differentiation and/or survival. These methods involve the administration of fbw7 e3 ligase inhibitors to inhibit c-myc ubiquitination in cancerous cell populations, such as leukemic initiating cell populations, that are responsible for disease initiation and progression..
09/25/14
20140288147
Methods of manipulating the fate of cells
A method of manipulating the fate of a cell which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding rna species (cur), (b) a modified cur, or (c) a compound that modifies or affects cur, under condition sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of rna:rna or rna:dna or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained.
09/25/14
20140287930
Sub-totipotent stem cell product and apparent hereditary modifying label thereof
Provided are a sub-totipotent stem cell product and epigenetic modification label thereof, a method for inducing the generation of the sub-totipotent stem cell product and identification for the epigenetic modification label of the differentiation potential of stem cells. Also provided is a use of histone modification states of sub-totipotent genes and/or differentiation related genes to predict the epigenetic modification label of the differentiation potentials of stem cells..
09/25/14
20140287495
Methods of inducing differentiation of stem cells
The present invention relates to methods of inducing differentiation of stem cells. In particular, the invention relates to methods of inducing differentiation of embryonic stem cells into muscle cells or vascular endothelial cells.
09/25/14
20140287452
Method for observing stem cells, method for removal of cell region in state tending toward differentiation, and device for observing stem cells
A method for observing stem cells by an observation device 1 comprises, placing stem cells c in a petri dish 11, mounting the petri dish 11 on a waveguide 21 via water 13, emitting illumination light l1 into the waveguide 21 and emitting the illumination light l1 to the stem cells c in the petri dish 11 via the water 13, and detecting scattered light l2, the scattered light l2 being the illumination light l1 emitted to the stem cells c that is scattered by the stem cells c and has passed through the waveguide 21. Then, in the light image detected by means of the scattered light l2, a region that is markedly darker than other regions is identified as being in the state tending toward differentiation..
09/25/14
20140287015
Ceramidase and cell differentiation
The present invention relates to methods of producing chondrocytes, improving the phenotype of a chondrocyte population, promoting chondrogenesis, maintaining a cell population in a differentiated state or increasing the number of cells of a population in a differentiated state, producing a population of differentiated cells, and treating certain diseases or disorders. Each of these methods involves treating a cell population with, and/or culturing a cell population in, a ceramidase.
09/25/14
20140286917
Isolated liver stem cells
Isolated liver progenitor stem cells and cell populations of isolated liver progenitor stem cells are disclosed. The progenitor stem cells originate from adult liver, especially human adult liver.
09/25/14
20140286916
Uses of growth and differentiation factor 8 (gdf-8)
The present invention relates to uses of growth and differentiation factor 8 (gdf-8) in vitro or in vivo for reducing the immunogenicity or risk of rejection of cells such as in particular mesenchymal stem cells (msc), tissues or materials. The present invention further relates to methods for differentiating msc in vitro or ex vivo into osteoprogenitors or osteoblastic cells or a cell population comprising osteoprogenitors and/or osteoblastic cells using fgf-2 and gdf-8.
09/25/14
20140286913
Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
The invention provides compositions that increase the mobilization, homing, expansion, and/or differentiation of stem cells and methods of using the same for the treatment of mammals.. .
09/18/14
20140281158
File differentiation based on data block identification
A memory system or flash card may include an algorithm for identifying and accounting for the rewrite frequency of data to be written to the card. The file system partition or file type of data may be used for monitoring rewrite frequency and predicting future rewrites.
09/18/14
20140276061
System and method for identification of breast ductal network
An imaging system induces an increased visibility of the fluid-containing ducts of the breast to enhance the imaging of the ducts, to improve differentiation of the ducts from the surrounding tissue and to detect lesions present within the duct. The imaging system includes a noninvasive fluid visibility increasing module configured for increasing the visibility of a fluid contained within one or more ducts of the breast and an increased fluid visibility detector configured for detecting the one or more ducts having increased fluid visibility to identify the one or more ducts within the ductal system of the breast.
09/18/14
20140275203
Method for inhibiting differentiation of osteoclast and pharmaceutical composition comprising thereof
The present invention is for method of treating metabolic bone disease, new compounds and pharmaceutical compositions comprising the active ingredients having inhibition effects on osteoclast differentiation. The pharmaceutical composition comprising new compounds according to the present invention can be used as medicines for treating metabolic bone diseases such as bone metastatic cancer, solid cancer bone metastasis, musculoskeletal complication by solid cancer bone metastasis, hypercalcemia by malignant tumor, multiple myeloma, primary bone tumor, osteoporosis, rheumatoid arthritis, osteoarthritis, periodontal disease, inflammatory resorption of alveolar bone, inflammatory resorption of bone, and paget's disease..
09/18/14
20140274920
Methods of treating or preventing overweight and obsesity in mammals by administering a composition comprising mannoheptulose
The present invention is based on the discovery that mannoheptulose (mhep) reduces or inhibits the differentiation process of fat stem cells into adipocytes so as to decrease the body's fat storage capacity. Compositions comprising a mhep, process of making the compositions, and methods of using the compositions for treating or preventing overweight and obesity in a mammal, such as, for example, a growing pet (e.g., puppy, kitten), or a spayed/neutered pet, are encompassed by the present invention..
09/18/14
20140273211
Methods and materials for hematoendothelial differentiation of human pluripotent stem cells under defined conditions
Methods and compositions for differentiating pluripotent stem cells into cells of endothelial and hematopoietic lineages are disclosed.. .
09/18/14
20140271905
Neural progenitor cell differentiation
Differentiation and stability of neural stem cells can be enhanced by in vitro or in vivo culturing with one or more extracellular matrix (ecm) compositions, such as collagen i, iv, laminin and/or a heparan sulfate proteoglycan. In one aspect of the invention, adult mammalian enteric neuronal progenitor cells can be induced to differentiate on various substrates derived from components or combinations of neural ecm compositions.
09/18/14
20140271682
Human homeobox gene ventx and macrophage terminal differentiation and activation, compositions and methods thereof
The invention generally relates to human biology discoveries and therapeutic and diagnostic compositions and methods based thereon. More particularly, the invention relates to human homeobox gene ventx and its control of macrophage terminal differentiation and activation, and related therapeutic and diagnostic compositions and methods of use, in particular in connection with inflammatory diseases..
09/18/14
20140271616
Compositions and methods for mesenchymal and/or chondrogenic differentiation of stem cells
Chondrocytes and compositions including chondrocytes produced via methods that do not require the formation of embryoid bodies are disclosed herein. The cells and compositions disclosed herein are suitable for use in treating osteoarthritis and other cartilage disorders or injury, as well as for tissue regeneration, particularly cartilage regeneration..
09/18/14
20140271566
In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (pec) and endocrine cells
A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described.
09/18/14
20140267078
Input differentiation for touch computing devices
Methods for differentiating touch inputs are disclosed. A method detects a touch input by receiving contact at a computing device's touch surface and identifies whether the touch input was received from a stylus based on additional input received from the stylus.
09/18/14
20140266806
Bicycle differentiation using video data analytics
A vehicular observation and detection apparatus and system incorporates a detection framework using video analysis to differentiate between motorized vehicles and bicycles for improved traffic flow and safety at intersections. The detection framework creates virtual zones overlaid on lanes of a roadway and analyzes input data representing objects in the virtual zones collected from one or more cameras positioned at or near the roadway..
09/18/14
20140259459
System and method for adhesive application of a customized sole-shaped pad
Systems, methods, and computer-readable storage media for applying an adhesive film to the sole of shoes. Application of a portion of the adhesive film can be performed by receiving a shoe on top of the adhesive film, which in turn is above a plate and compressible pins.
09/11/14
20140257938
System and method for analyzing hospitality industry data and providing analytical performance management tools
Hospitality customer acquisition and retention costs are analyzed on a per-channel, channel-agnostic, and aggregated basis. Hotel performance is analyzed by examining net revenue by channel (accounting for each channel's contribution to operating expenses and profits), net revenue in aggregate (via net revpar and revpar capture metrics), and the relative benefit of sales and marketing expenses by quantifying net sales and marketing efficiency.
09/11/14
20140256917
Compositions and methods for osteogenic gene therapy
The present disclosure provides compositions and methods for increasing bone growth and/or enhancing wound healing, for example, fracture repair. The disclosure provides recombinant nucleic acids useful for promoting bone growth.
09/11/14
20140256043
Small chemical compound which promotes induction of differentiation of stem cells into insulin-producing cells and method for inducing differentiation of stem cells into insulin-producing cells using said small chemical compound
A purpose of the present invention is to provide a small chemical compound which especially promotes induction of the differentiation of es cells into insulin-producing cells. Another purpose of the present invention is to provide: a method for inducing the differentiation of es cells into insulin-producing cells using the compound; and an agent for promoting induction of the differentiation into insulin-producing cells.
09/11/14
20140256042
Method of producing erythrocytes without feeder cells
Provided herein are methods of producing erythrocytes from hematopoietic cells, particularly hematopoietic cells from placental perfusate in combination with hematopoietic cells from umbilical cord blood, wherein the method results in accelerated expansion and differentiation of the hematopoietic cells to more efficiently produce administrable erythrocytes. Further provided herein is a bioreactor in which hematopoietic cell expansion and differentiation takes place..
09/11/14
20140255506
Osteoinductive demineralized cancellous bone
An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone.
09/11/14
20140253698
System, apparatus, and method for enhancing stereoscopic images
The ability of some people to perceive simulated stereoscopic images or even actual stereoscopic images can be enhanced by treating the two eyes differently. The disclosed system can enhance stereoscopic images by selectively modifying the incoming images using right/left differentiation filter.
09/11/14
20140253199
Systems, apparatus, and methods for providing continuous-time signal differentiation and integration
Systems and methods for providing an approximate differentiation and integration of an input continuous-time signal are provided. The disclosed systems include a continuous-time delay block configured to receive an input continuous-time signal and to delay the input continuous-time signal by a predetermined delay factor to generate a delayed input continuous-time signal, a processing block configured to determine a difference or a sum between two continuous-time signals, and a multiplication block configured to multiply an input continuous signal to provide a multiplied input continuous signal..


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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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