Differentiation

Differentiation-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Method and system for completing loosely specified mdts
May 25, 2017 - N°20170149692

A method is implemented by a networking device that is functioning as a computing node. The method resolves sub-trees of a loosely specified multicast distribution tree (mdt). The method utilizes global identifiers for sub-trees to enable differentiation of traffic of different sub-trees at shared replication nodes. The method is implemented at each of the nodes of the network that are ...
NEW Gesture recognition and control based on finger differentiation
May 25, 2017 - N°20170147193

An embodiment of a computer implemented method of performing a processing action includes detecting an input from a user via an input device of a processing device, the input including a touch by at least one finger of a plurality of fingers of the user, estimating a gesture performed by the at least one finger based on the touch, measuring ...
NEW Gesture recognition and control based on finger differentiation
May 25, 2017 - N°20170147073

An embodiment of a computer implemented method of performing a processing action includes detecting an input from a user via an input device of a processing device, the input including a touch by at least one finger of a plurality of fingers of the user, estimating a gesture performed by the at least one finger based on the touch, measuring ...
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NEW Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system
May 25, 2017 - N°20170146555

Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (cns injury) including traumatic brain injury (tbi), traumatic spinal cord injury (sci) and chronic traumatic encephalopathy (cte). ...
NEW Nanogap electrodes with dissimilar materials
May 25, 2017 - N°20170146511

The present disclosure provides devices, systems and methods for effectuating nanoelectrodes for use with determining the sequence of double stranded biopolymers. Various modified bases and different metals may be utilized alone or in combination so as to provide differentiation between different nucleobases and to determine which base is associated with which strand.
NEW Monitoring the effect of substances on in vitro tissue
May 25, 2017 - N°20170146473

The invention relates to methods and means for the non-destructive characterization of biological tissue in vitro and in particular the determination of the effect of substances on said biological tissue or the determination of the maturity or degree of differentiation of said tissue, using non-invasive and in particular recurrently measurable electrical variables. These variables can be calculated, by means of ...
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NEW Method for stem cell differentiation in vivo by delivery of morphogenes with mesoporous silica and ...
May 25, 2017 - N°20170145382

A pharmaceutical active ingredient for cell differentiation to alleviate cell and cell-related deficiencies in mammals comprising porous silica containing a releasable agent capable of contributing to a cell environment conducive for stem cell differentiation in co-implanted stem cells and/or in endogenous stem cells.
NEW Method of generating multilineage potential cells from lymphocytes
May 25, 2017 - N°20170145381

The present invention relates generally to a method of generating cells exhibiting multilineage potential and to cells generated thereby. More particularly, the present invention is directed to an in vitro method of generating mammalian stem cells from cd4* mononuclear cells, cd8* mononuclear cells, cd25* mononuclear cells, cd19* mononuclear cells or cd20* mononuclear cells and to cells generated thereby. This finding ...
NEW Antibody to gdf8 and uses thereof
May 25, 2017 - N°20170145084

The disclosure provides novel molecules related to growth and differentiation factor-8 (gdf8), in particular epitopes specific to gdf8 and other specific antagonists of gdf8 in particular anti-gdf8 antibodies or antigen binding protein or fragment thereof which may inhibit gdf8 activity and signal in vitro and/or in vivo. The disclosure also provides for an immunoassay used to detect and quantitate ...
NEW Dendritic cell immune receptor activator, method for activating dendritic cell immune receptor, osteoclast formation inhibitor, ...
May 25, 2017 - N°20170143754

Wherein, in the formula, a sialic acid does not exist at two non-reducing terminals, and each of x and y independently represents 3 or 4.
NEW Catheter with omni-directional optical lesion evaluation
May 25, 2017 - N°20170143420

A catheter is adapted to ablate tissue and provide lesion qualitative information on a real time basis, having an ablation tip section with a generally omni-directional light diffusion chamber with one openings to allow light energy in the chamber to radiate the tissue and return to the chamber. The chamber is irrigated at a positive pressure differential to continuously flush ...
NEW Device and method for palpation of tissues for characterization and mechanical differentiation of subcutaneous structures
May 25, 2017 - N°20170143208

A palpation device for palpation of tissues for characterization (e. G., qualification and/or quantification) of subcutaneous structures is provided. The palpation device includes a frame formed from a substantially rigid material and comprising an opening; a tonometric lens extending through the opening of the frame; and a radiation source. The lens is configured to at least partially impinge a ...
Source differentiation of machine data
Splunk Inc.
May 18, 2017 - N°20170139968

Methods and apparatus consistent with the invention provide the ability to organize, index, search, and present time series data based on searches. Time series data are sequences of time stamped records occurring in one or more usually continuous streams, representing some type of activity. In one embodiment, time series data is organized into discrete events with normalized time stamps and ...
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  • 383+ full patent PDF documents of Differentiation-related inventions.
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Treatment of age-related macular degeneration using rna complexes that target myd88 or tlr3
Olix Pharmaceuticals, Inc.
May 18, 2017 - N°20170137828

In certain aspects, provided herein are rna complexes that inhibit myeloid differentiation primary response gene 88 (myd88) and/or toll-like receptor 3 (tlr3) and are useful in the treatment of age-related macular degeneration (amd). In certain aspects, provided herein are pharmaceutical compositions comprising such rna complexes and methods of using such rna complexes and pharmaceutical compositions.
Use of an mirna to reduce proliferation of a cancer cell
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
May 18, 2017 - N°20170137822

A method is provided for decreasing at least one of the proliferation and the migration of a cancer cell comprising contacting a cancer cell with an effective amount of a pharmaceutically acceptable composition comprising a microrna (mirna) having a nucleotide sequence having at least 80% sequence similarity to the nucleotide sequence of mir-3189-3p derived from the mir-3189 mitron of ...
Methods of preparing t cells for t cell therapy
National Cancer Institute
May 18, 2017 - N°20170136063

Provided herein are methods for delaying or inhibiting t cell maturation or differentiation in vitro for a t cell therapy, comprising contacting one or more t cells from a subject in need of a t cell therapy with an akt inhibitor and at least one of exogenous interleukin-7 (il-7) and exogenous interleukin-15 (il-15), wherein the resulting t cells exhibit delayed ...
Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
Irm Llc
May 18, 2017 - N°20170136029

The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor ...
Per queue per service differentiation for dropping packets in weighted random early detection
Ciena Corporation
May 11, 2017 - N°20170134282

Systems and methods for per service differentiation for congestion avoidance through dropping packets based on service priority include receiving an ingress packet; responsive to no congestion, providing the ingress packet to a queue of one or more queues; and, responsive to congestion, during a congestion window, one of providing the ingress packet to the queue and dropping the packet based ...
Method and kit for detection of deltanoid-resistant leukemia cells and antibody for use therein
Wroclawskie Centrum Badan Eit+ Sp. Z O.o.
May 11, 2017 - N°20170131281

The present invention relates to a method and a kit and antibodies utilized therein, allowing to distinguish between leukemia cells resistant to and leukemia cells susceptible to differentiation induced by deltanoids.
Composition for inducing direct transdifferentiation of somatic cell into vascular progenitor cell, and use thereof
Unist(ulsan National Institute Of Science And Techology)
May 11, 2017 - N°20170130204

The present invention relates to a composition for inducing direct transdifferentiation of a somatic cell into a vascular progenitor cell and a use thereof and, more specifically, to a composition for inducing direct transdifferentiation of a somatic cell into a vascular progenitor cell, a pharmaceutical composition for the prevention or treatment of ischemic vascular diseases, a cell therapeutic agent for ...
Methods for neural conversion of human embryonic stem cells
Memorial Sloan Kettering Cancer Center
May 11, 2017 - N°20170130199

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction ...