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Differentiation patents



      
           
This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS


Date/App# patent app List of recent Differentiation-related patents
01/29/15
20150031556
 System and  genomic profiling patent thumbnailnew patent System and genomic profiling
The present invention relates to a system and method of genomic profiling and is particularly useful in genomic differentiation of heterogeneous and polyclonal neoplastic cell populations, preferably of flow sorted formalin fixed paraffin embedded samples. The present invention includes methods of improving resolution for identifying aberration in variable carcinoma genomes and/or heterogeneous cell populations.
The Translational Genomics Research Institute
01/29/15
20150030662
 Generation of brown adipose tissue (bat) from mesenchymal cells patent thumbnailnew patent Generation of brown adipose tissue (bat) from mesenchymal cells
Methods of generating functional human brown adipocytes, comprising exposing human stem cells, progenitor cells, or white adipocytes to culture with an differentiation cocktail that comprises one or more browning agents (e.g., one or more macromolecular crowders), and optionally one or more adipogenic agents, are described, as are populations of human brown adipocytes generated by the methods, and uses for the populations. Methods of generating functional human brown adipocytes in an individual, such as by administering a pharmaceutical composition comprising an differentiation cocktail, are also described..
Auckland Uniservices Ltd
01/29/15
20150030634
 Proliferating agent for monocyte, culture medium for proliferating monocyte,  producing monocyte,  producing dendritic cell, and  producing dendritic cell vaccine patent thumbnailnew patent Proliferating agent for monocyte, culture medium for proliferating monocyte, producing monocyte, producing dendritic cell, and producing dendritic cell vaccine
The purpose of the present invention is to provide a means for proliferating a monocyte with high efficiency and in a simple manner. The present invention provides a proliferating agent for a monocyte, which consists of at least one component selected from flt-3l, il-3 and ifn-γ and can be used before a treatment for differentiation of a monocyte into a dendritic cell.
Hakushikouseikai Foundation
01/29/15
20150030619
 Activation and expansion of t cell subsets using biocompatible solid substrates with tunable rigidity patent thumbnailnew patent Activation and expansion of t cell subsets using biocompatible solid substrates with tunable rigidity
The present invention provides compositions and methods for activation and expansion of t cells using a biocompatible solid substrate with tunable rigidity. Rigidity of a substrate is an important parameter that can be used to control the overall expansion and differentiation of t cells..
The Trustees Of Columbia University In The City Of New York
01/29/15
20150030595
 Myostatin inhibitor comprising extracellular water-soluble domains of dlk1 as active ingredient patent thumbnailnew patent Myostatin inhibitor comprising extracellular water-soluble domains of dlk1 as active ingredient
The present invention relates to a myostatin inhibitor comprising extracellular water-soluble domains of delta-like 1 homolog (dlk1) as active ingredients. More particularly, the present invention relates to a composition for inhibiting myostatin activity, comprising, as active ingredients, extracellular water-soluble domains of dlk1 or a deletion mutant of extracellular water-soluble domains of dlk1.
Antibody And Receptor Therapeutics Co., Ltd.
01/29/15
20150030568
 Use of stem cells to generate inner ear cells patent thumbnailnew patent Use of stem cells to generate inner ear cells
This invention relates generally to methods and compositions for inducing stem cell or progenitor cell differentiation, and more particularly to methods and compositions for inducing differentiation of stem cells and/or progenitor cells into cells that function within the inner ear.. .
Massachusetts Eye And Ear Infirmary
01/29/15
20150029312
 Apparatus and  detecting object automatically and estimating depth information of image captured by imaging device having multiple color-filter aperture patent thumbnailnew patent Apparatus and detecting object automatically and estimating depth information of image captured by imaging device having multiple color-filter aperture
Disclosed are an apparatus and a method for detecting an object automatically and estimating depth information of an image captured by an imaging device having a multiple color-filter aperture. A background generation unit detects a movement from a current image frame among a plurality of continuous image frames captured by an mca camera to generate a background image frame corresponding to the current image frame.
Chung-ang University Industry-academy Cooperation Foundation
01/22/15
20150026250
 System and  delivering data that provides service differentiation and monetization in mobile data networks patent thumbnailSystem and delivering data that provides service differentiation and monetization in mobile data networks
An exemplary system according to the present disclosure comprises a lower tier radiolet™ that is in communication with a local switching office of a mobile data network, and an upper tier radiolet™ that is in communication with the lower tier radiolet™ and an internet datacenter. In operation, the upper tier radiolet™ receives data extracted from the internet datacenter and distributes at least a portion of the received data to the lower tier radiolet™.
Alef Mobitech Inc.
01/22/15
20150025501
 Composition and  the treatment or prevention of spinal disorders patent thumbnailComposition and the treatment or prevention of spinal disorders
The present invention provides compositions of matter suitable for the prevention of and/or treatment of a spinal disorder and/or spinal pain, e.g., caused by and/or associated with intervertebral disc (ivd) degeneration, and methods of treatment of a spinal disorder and/or spinal pain. For example, the compositions of the present invention comprise a modulator of growth differentiation factor (gdf)-6 signaling sufficient to reduce or prevent or delay ivd degeneration and/or to enhance or induce ivd regeneration.
01/22/15
20150024484
 Antibody inhibitors of gdf-8 and uses thereof patent thumbnailAntibody inhibitors of gdf-8 and uses thereof
The disclosure provides novel antibodies against growth and differentiation factor-8 (gdf-8), including antibody fragments, which inhibit gdf-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism..
Wyeth Llc
01/22/15
20150023932

Engineered peptide (ep)-directed protein intercellular delivery system and uses thereof


The present invention provides an intercellular protein delivery system comprising an engineered peptide (ep), composed of secretion part (sp) and nuclear translocation part (ntp), a functional or therapeutic protein (fp), cells that express the fusion proteins and cells that accept the fusion proteins. The system can be used in vivo or in vitro to sustainably supply proteins of interest for cellular reprogramming, cellular differentiation and cell-based protein therapies..
01/22/15
20150023927

Conversion of somatic cells into functional spinal motor neurons, and methods and uses thereof


The present invention provides methods of transdifferentiation of somatic cells, for example, directly converting a somatic cell of a first cell type, e.g., a fibroblast into a somatic cell of a second cell type, are described herein. In particular, the present invention generally relates to methods for converting a somatic cell, e.g., a fibroblast into a motor neuron, e.g., an induced motor neuron (imn) with characteristics of a typical motor neuron.
President And Fellows Of Harvard College
01/22/15
20150022026

Power quality differentiation in hazard detection systems


Hazard detection systems according to embodiments described herein are operative to provide failsafe safety detection features and user interface features using circuit topology and power budgeting methods that minimize power consumption. The safety detection features can monitor environmental conditions (e.g., smoke, heat, humidity, carbon monoxide, carbon dioxide, radon, and other noxious gasses) in the vicinity of the hazard detection system associated and alarm occupants when an environmental condition exceeds a predetermined threshold..
Google Inc.
01/22/15
20150020594

Determination assist system of ultrasonic testing, determination assist ultrasonic testing, determination assist program of ultrasonic testing, and computer-readable storage medium for storing determination assist program of ultrasonic testing


A determination assist system including a first image generating section for generating a first planar image based on data of a first test index; a second image generating section for generating a second planar image based on data of a second test index; a differentiation section which differentiates the first planar image and the second planar image to generate a first differential image and a second differential image, respectively; a binarization section which binarizes the first differential image to generate a first binary image including a first region which is not less than a first threshold and a second region, which is less than the first threshold, and binarizes the second differential image to generate a second binary image including a third region which is not less than a second threshold and a fourth region which is less than the second threshold; and a determination image generating section.. .
Kawasaki Jukogyo Kabushiki Kaisha
01/15/15
20150020044

Productized approach for developing multi instance single code base product/application with centralized management


The embodiments herein relate to product/application customization and, more particularly, to develop multi instance single code base product/application with centralized management. The central repository present in the system fetches and holds all differentiation information for various instances of the application.
Hcl Technologies Ltd.
01/15/15
20150019873

System for embedded biometric authentication, identification and differentiation


An electronic device authenticates a user without requiring active input from the user. At least one user interface receives a plurality of user inputs to the electronic device that are unrelated to an active authentication action of the user of the electronic device.
Hgn Holdings, Llc
01/15/15
20150017724

Method for guiding the derivation of endothelial cells from human pluripotent stem cells employing two-dimensional, feeder-free differentiation


This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (pscs) into endothelial cells (ecs) in vitro, by plating a single-cell suspension of pscs onto a suitable surface such as type iv collagen and culturing the cells with vegf after which ecs can be harvested. A preferred embodiment of the method first cultures the cells without vegf and then sequentially cultures the cells with vegf.
The Johns Hopkins University
01/15/15
20150017718

Method for inducing cardiac differentiation of pluripotent stem cell


(2) culturing a cell produced in the step (1) in a medium containing one or more wnt signaling inhibitor.. .
01/15/15
20150017674

Method for differentiation of pluripotent stem cells into vascular bed cells


This application relates to a method for differentiating pluripotent stem cells (pscs) into vascular bed cells. Moreover this application relates to a method for differentiating human embryonic stem cells (escs) and induced pluripotent stem cells (ipscs) into vascular bed cells based on linked steps of chemically defined medium inductions..
Hoffmann-la Roche Inc.
01/15/15
20150017669

Process and its application for improving reproducibility in maldi-tof glycan profiling of human serum: experimental procedure and application to the screening for ovarian tumors


Disclosed is that the most crucial point in the quantitative analysis of maldi-tof ms is to minimize quantitative variances (rsds, relative standard deviations) of peak intensities of obtained spectrum data. The minimized rsd is translated into improved reproducibility of the data and finally leads to high accuracy of the results.
Hudson Surface Technology, Inc.
01/15/15
20150017135

In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (pec) and endocrine cells


A human immature endocrine cell population and methods for making an immature endocrine cell population are provided. Specifically, immature beta cells and methods for production of immature beta cells are described.
Viacyte, Inc.
01/15/15
20150015928

Novel fast fourier transform (fft) analysis using waveform-embedded or waveform-modulated coherent beams and holograms


Method of fast fourier transform (fft) analysis for collecting waveforms and other vibrational intelligence and modulating or embedding same into one or more coherent reference beams of an n-dimensional holographic recording device for producing one or more holograms of objects, including singularity points in space. The result provides wholesale differentiation of waveforms distinguishable from others based on their spectral characteristics.
01/15/15
20150015676

Astigmatic depth from defocus imaging


A rangefinder has a depth camera and a computer. The depth camera is positioned to receive electromagnetic energy from a scene.
Ellis Amalgamated, Llc Dba Optics For Hire
01/15/15
20150015173

Motor control device


A motor control device includes a model control system that controls a motor machine model position using a target value (a position instruction after differentiation) related to a position instruction, and a feedback control system that controls a motor position using the target value (a position instruction after differentiation) related to the position instruction and an amount of control (model position) of the model control system. The feedback control system controls the motor position using the amount of control (model position) of the model control system at all times..
Sanyo Denki Co., Ltd.
01/08/15
20150013024

Near-infrared light-activated proteins


Methods and constructs are provided for controlling processes in live animals, plants or microbes via genetically engineered near-infrared light-activated or light-inactivated proteins including chimeras including the photosensory modules of bacteriohytochromes and output modules that possess enzymatic activity and/or ability to bind to dna, rna, protein, or small molecules. Dna encoding these proteins are introduced as genes into live animals, plants or microbes, where their activities can be turned on by near-infrared light, controlled by the intensity of light, and turned off by near-infrared light of a different wavelength than the activating light.
University Of Wyoming
01/08/15
20150011496

Methods and compositions for stimulating bone regeneration


The invention provides methods and compositions for stimulating or promoting bone regeneration or repairing bone fracture or for stimulating or increasing differentiation or activation of osteoblasts by administering to a subject a therapeutically effective amount of an adenosine receptor agonist, or an analog, derivative or combination thereof, an adenosine receptor antagonist, or an analog, derivative or combination thereof, or adenosine or a compound that upregulates, increases the amount of or increases the biological activity of adenosine. The invention also extends to pharmaceutical compositions such as those comprising an agent that modulates an adenosine receptor such as an adenosine a2a agonist or a1 antagonist..
New York University
01/08/15
20150011429

Serum-free freezing medium used in adipose-derived stem cells and establishment of adipose-derived stem cell library


Disclosed is a serum-free freezing medium used in adipose-derived stem cells and a method for establishing an adipose-derived stem cell library. The serum-free freezing medium comprises a serum-free culture medium, dimethyl sulfoxide and a serum substitution component ksr; the defects of unstable freezing quality of the adipose-derived stem cells and influence of harmful factors in serum on the adipose-derived stem cells are solved, and the adipose-derived stem cells stored have the advantages of high survival percentage, well adherence growth and strong differentiation capacity..
Cellular Biomedicine Group (shanghai) Ltd
01/08/15
20150011418

Method for determining the immune status of a subject


The present invention is a method for using levels of soluble clusters of differentiation (cd) proteins, or cell surface-localized cd proteins extracted from t lymphocytes for determining the immune status of a subject. The present invention also a kit containing a cd protein extraction means and at least one antibody which specifically binds a cd protein for use in carrying out the method of the invention..
Montecito Bio-sciences, Ltd.
01/08/15
20150010607

Liquefaction of bone matrix


The invention relates to methods of preparing a bone matrix solution, a bone matrix implant, and variants thereof. The invention also relates to methods of cell culture using the same.
Lifenet Health
01/08/15
20150010583

Ex vivo nk cell differentiation from cd34+ hematopoietic cells


The present invention relates to the ex vivo differentiation of nk cells from cd34+ hematopoietic stem cells. Such nk cells and their progenitor cells can be used in therapies of a broad range of malignancies.
Ipd-therapeutics B.v.
01/08/15
20150010516

Novel msc surface marker


The present invention relates to the use of at least one antibody which binds to the susd2 antigen, or to functional fragments of the antibody, in combination with at least one of the following: an antibody which binds to cd140b, an antibody which binds to cd56, and/or an antibody which binds to tnap, or functional fragments thereof, for isolation of mesenchymal stem cells, especially those having particularly chondrocytic and osteogenic differentiation potential. The invention further relates to processes for isolating such stem cells using these antibodies.
Eberhard-karls-universitaet Tuebingen Universitaetsklinikum
01/08/15
20150010515

Mammalian neural plate border stem cells capable of forming neural tube and neural crest cell lineages including central and peripheral neurons


The present invention relates to a method for producing mammalian neural plate border stem cells (npbscs), comprising: (a) differentiation of mammalian pluripotent stem cells by (a-i) culturing mammalian pluripotent stem cells in pluripotent stem cell medium for about 24 to about 96 hours, wherein the pluripotent stem cell medium comprises: (i) an inhibitor of the activin/tgf-β signalling pathway; (ii) an inhibitor of the bmp signalling pathway; (iii) an activator of the canonical wnt signalling pathway; and (iv) an activator of the hedgehog signalling pathway; subsequently (a-ii) culturing the cells obtained in step (a-i) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises: (i) an inhibitor of the activin/tgf-β signalling pathway; (ii) an inhibitor of the bmp signalling pathway; (iii) an activator of the canonical wnt signalling pathway; and (iv) an activator of the hedgehog signalling pathway; subsequently (a-iii) culturing the cells obtained in step (a-ii) for about 24 to about 96 hours in a neural medium, wherein the neural medium comprises: (i) an activator of the canonical wnt signalling pathway; (ii) an activator of the hedgehog signalling pathway; and (iii) an inhibitor of oxidation; and (b) plating the obtained differentiated mammalian pluripotent stem cells in npbscs expansion medium, wherein the npbscs expansion medium comprises (i) an activator of the canonical wnt signalling pathway; (ii) an activator of the hedgehog signalling pathway; and (iii) an inhibitor of oxidation; and expanding the cells in the npbscs expansion medium for about 24 to about 96 hours; (c) splitting the cells obtained in (b) and further expanding the cells in the npbscs expansion medium; and (d) repeating step (c) at least two times. The present invention further relates to neural plate border stem cells obtainable by the method of the invention and the use of the cells of the invention in medicine..
Max- Planck-gesellschaft Zur Förderung Der Wissenschaften E.v.
01/08/15
20150010514

Midbrain dopamine (da) neurons for engraftment


The present invention relates to the field of stem cell biology, in particular the lineage specific differentiation of pluripotent or multipotent stem cells, which can include, but is not limited to, human embryonic stem cells (hesc) in addition to nonembryonic human induced pluripotent stem cells (hipsc), somatic stem cells, stem cells from patients with a disease, or any other cell capable of lineage specific differentiation. Specifically described are methods to direct the lineage specific differentiation of hesc and/or hipsc into floor plate midbrain progenitor cells and then further into large populations of midbrain fate foxa2+lmx1a+th+ dopamine (da) neurons using novel culture conditions.
Memorial Sloan-kettering Cancer Center
01/08/15
20150010508

Methods and compositions relating to islet cell neogenesis


The present invention provides methods and kits for treating diseases and conditions associated with impaired pancreatic function. The present invention further provides methods of stimulating islet cell neogenesis and stimulating islet cell differentiation from progenitor cells..
Curedm Group Holdings, Llc
01/08/15
20150010501

Intervertebral disc repair compositions and methods


The present invention provides compositions, methods and devices for treatment of degenerative disc disease or the repair of a disc in need of repair. The composition or the formulation includes freshly isolated or culture expanded ela cells, which can be cyropreserved.
Parcell Laboratories, Llc
01/08/15
20150009826

Hierarchical traffic differentiation to handle congestion and/or manage user quality of experience


Methods, apparatuses and systems for performing hierarchical traffic differentiation and/or employing hierarchical traffic differentiation are provided. These methods, apparatuses and systems may be implemented to, for example, handle congestion and/or to manage user quality of experience (qoe).
Vid Scale, Inc
01/01/15
20150005941

Dynamic predictor for articulated mechanisms


A dynamic predictor usable for rapid and accurate calculation of joint commands of an articulated dynamical mechanism describes the relationship between the joints in the form of a differential equation. The predictor solves this differential equation for predicted joint states by fitting a polynomial equation having free parameters describing the predicted joint states to the differential equations by minimizing the differential equation residuals.
Wisconsin Alumni Research Foundation
01/01/15
20150005381

Method for modulating stem cell growth


In one embodiment, provided is a composition including a prostaglandin compound for modulating stem cell proliferation and/or differentiation in a mammalian subject. In another embodiment, the instant application is directed to a composition which includes a prostaglandin compound for modulating proliferation and/or differentiation of stem cells of a mammalian subject, in which the stem cells are contacted directly or indirectly with the composition of the invention..
Sucampo Ag
01/01/15
20150004701

Method for differentiating stem cells into neurons


The present invention relates to a method for differentiating stem cells into neurons, and is characterized in that stem cells are treated with a culture additive comprising lipoic acid, albumin, hydrocortisone, and insulin after culturing for differentiation into neurons. Since the neurons produced according to the method for producing neurons of the present invention express nestin, neurod1, neuron-specific enolase (nse), neurofilament (nf), tau, microtubule-associated protein 2 (map2), and doublecortin (dcx), just as normal mature neurons do, the neurons of the present invention can be effectively used in various therapeutic agents for neurons and as cell origins for an in vitro study system..
Dongguk University Industry-academic Cooperation Foundation
01/01/15
20150004178

Anti-human sema4a antibodies useful to treat disease


Anti-human sema4a antibodies useful in treating autoimmune diseases, cancers and other disease are provided herein. Anti-human sema4a antibodies can inhibit t cell proliferation and th2 differentiation induced by il-4, anti-cd3, anti-cd28 and recombinant sema4a..
Board Of Regents, The University Of Texas System
01/01/15
20150004144

Differentiation into brown adipocytes


The technology described herein is directed to methods and compositions relating to the differentiation and activity of brown adipocytes, and the therapeutic uses thereof.. .
The General Hospital Corporation
01/01/15
20150003554

Radio transmission apparatus, radio reception apparatus, and data transmission method


A radio transmission apparatus includes a plurality of transmission antennas, a start symbol generating unit that generates a start symbol as a reference signal during the start of differential coding, a differential coding unit (a differential coding unit, a transmission-signal-power calculating unit, and a 1/square root operation unit) that subjects a transmission symbol, to which information bits are mapped, to differential coding and generates a symbol after differentiation, and a space-time coding unit that subjects the start symbol or the symbol after differentiation to space-time coding and generates signals to be transmitted from transmission antennas. The differential coding unit determines, on the basis of electric power of the start symbol or electric power of the symbol after differentiation generated last time, electric power of the symbol after differentiation generated in the current differential coding processing..
Mitsubishi Electric Corporation
01/01/15
20150000882

Heat-dissipating structure having suspended external tube and internally recycling heat transfer fluid and application apparatus


The present invention is provided with a suspended external tube (101) and an inner tube (103) installed therein, wherein the diameter differentiation between the inner diameter of the external tube and the outer diameter of the inner tube is served to constitute a partitioned space as the fluid path, the front tube of the external tube is served to be installed with an electric energy application device assembly (108), and through the fluid pump (105) serially installed to the heat transfer fluid path pumping the heat transfer fluid to form a closed recycling fluid path, and through the exposed portion of the outer surface of the suspended external tube (101), temperature equalizing operation is enabled to perform with the external gaseous environment or the liquid or solid environment manually installed but not disposed in the stratum or liquid of the shallow ground natural thermal energy body.. .
01/01/15
20150000878

Heat-dissipating structure having embedded support tube to form internally recycling heat transfer fluid and application apparatus


The invention is provided with a support tube (101) and an inner tube (103) installed inside thereof, the diameter differentiation between the inner diameter of the support tube (101) and the outer diameter of the inner tube (103) is formed with a partitioned space for constituting a fluid path, the upper tube of the support tube (101) is installed with an electric energy application device assembly (108), and through the fluid pump (105) serially installed on the heat transfer fluid path to pump the heat transfer fluid to form a closed recycling flow, and through passing the support tube (101) of the mentioned closed recycling heat transfer fluid path and the exposed portion at the outer surface of the relevant structure, thereby enabling to perform temperature equalizing operation with the external gaseous or solid or liquid environment and/or the soil or liquid of the shallow ground natural thermal energy body.. .
01/01/15
20150000877

Heat-dissipating structure having suspended external tube and internally recycling heat transfer fluid and application apparatus


The present invention is provided with a suspended external tube (101) and an inner tube (103) installed therein, wherein the diameter differentiation between the inner diameter of the external tube and the outer diameter of the inner tube is served to constitute a partitioned space as the fluid path, the front tube of the external tube is served to be installed with an electric energy application device assembly (108), and through the fluid pump (105) serially installed to the heat transfer fluid path pumping the heat transfer fluid to form a closed recycling fluid path, and through the exposed portion of the outer surface of the suspended external tube (101), temperature equalizing operation is enabled to perform with the external gaseous environment or the liquid or solid environment manually installed but not disposed in the stratum or liquid of the shallow ground natural thermal energy body.. .
01/01/15
20150000876

Heat-dissipating structure having suspended external tube and internally recycling heat transfer fluid and application apparatus


The present invention is provided with a suspended external tube (101) and an inner tube (103) installed therein, wherein the diameter differentiation between the inner diameter of the external tube and the outer diameter of the inner tube is served to constitute a partitioned space as the fluid path, the front tube of the external tube is served to be installed with an electric energy application device assembly (108), and through the fluid pump (105) serially installed to the heat transfer fluid path pumping the heat transfer fluid to form a closed recycling fluid path, and through the exposed portion of the outer surface of the suspended external tube (101), temperature equalizing operation is enabled to perform with the external gaseous environment or the liquid or solid environment manually installed but not disposed in the stratum or liquid of the shallow ground natural thermal energy body.. .
01/01/15
20150000875

Heat-dissipating structure having embedded support tube to form internally recycling heat transfer fluid and application apparatus


The invention is provided with a support tube (101) and an inner tube (103) installed inside thereof, the diameter differentiation between the inner diameter of the support tube (101) and the outer diameter of the inner tube (103) is formed with a partitioned space for constituting a fluid path, the upper tube of the support tube (101) is installed with an electric energy application device assembly (108), and through the fluid pump (105) serially installed on the heat transfer fluid path to pump the heat transfer fluid to form a closed recycling flow, and through passing the support tube (101) of the mentioned closed recycling heat transfer fluid path and the exposed portion at the outer surface of the relevant structure, thereby enabling to perform temperature equalizing operation with the external gaseous or solid or liquid environment and/or the soil or liquid of the shallow ground natural thermal energy body.. .
12/25/14
20140379808

Download resource recommendation method, system and storage medium


A method for recommending a download resource includes: obtaining a download record of a target user, obtaining a target user group associated with the target user according to the download record; obtaining download records of the target user group and download records of a global user group; processing the downloading records of the target user group and the download records of the global user group to generate, for a download resource in the download records of the target user group, a differentiation degree between the download resource in the download records of the target user group and the download resource in the download records of the global user group; and sorting download resources in the download records of the target user group according to the differentiation degree, and recommending the top-ranking predetermined number of download resources to the target user.. .
Tencent Technology (shenzhen) Company Limited
12/25/14
20140378665

Growth differentiation factor 15 (gdf-15) polypeptides


Gdf15 polypeptides, constructs comprising gdf15, and mutants thereof are provided. In various embodiments the gdf15 polypeptides, constructs comprising gdf15, and mutants thereof, can be of use in the treatment or ameliorating a metabolic disorder.
Amgen Inc.
12/25/14
20140377832

Induction of dedifferentiation of mesenchymal stromal cells


The invention relates to induction of reprogramming of somatic cells, by methods which require mild growth conditions. Disclosed are methods of inducing dedifferentiation of mesenchymal stromal cell (msc), by seeding or incubating mesenchymal stromal cells (mscs) at low density, and without introduction or expression of exogenous genes in the cells..
Yeda Research And Development Co. Ltd.
12/25/14
20140377243

Cell-penetrating fusion protein for regenerating or proliferating stem cell


The present invention relates to a cell permeable fusion protein for strengthening regenerative potential of stem cells, and more particularly to a cell permeable fusion protein for strengthening regenerative potential of stem cells for stimulating the differentiation of stem cells, inhibiting apoptosis, maintaining the functionality of stem cells and restoring the stress-inhibited functionality of stem cells.. .
Seoul National University R And Db Foundation
12/25/14
20140377235

Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions


The present invention features the use of a synthetic triterpenoid to induce gene expression and differentiation of stem or progenitor cells in the treatment of bone/cartilage diseases or conditions.. .
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
12/25/14
20140377232

Innervation of engineered structures


Methods of generating an innervated muscle structures are disclosed as well as bioengineered structures for tissue repair or regeneration. The methods can include the steps of obtaining populations of smooth muscle cells and neuronal progenitor cells and then seeding the cells together onto a matrix material, followed by culturing the seeded cells to form an innervated smooth muscle cell construct of directionally oriented smooth muscle cells.
Wake Forest University Health Sciences
12/18/14
20140372078

Method and device for detecting a failure on an aircraft


The detecting means (1) comprise measuring means (2) adapted to measure and provide at least one raw data corresponding to an aircraft parameter, computing means (3) adapted to estimate at least one derivative of said raw data, and detecting means (4) adapted to detect a failure with the aid of said derivative, said computing means (3) being adapted to estimate said derivative by differentiation.. .
Universite De Bordeaux
12/18/14
20140371579

Rapid image analysis - fleming harrington redistribution wash-in washout differentiation of inflammatory vascular disease (ivd) and tissue viability


The present invention provides a method for detecting abnormal coronary blood flow by “quantifying” emissions of radiopharmaceuticals after stressing the heart under “same state” conditions for detection of inflammatory vascular (ivd) disease and differentiation of (a) ischemic heart disease due reduced lumen responsiveness to demand for more coronary blood flow and (b) vulnerable inflammatory plaque disease with reduced lumen responsiveness. The present invention also provides a method for detection of myocyte viability by using the “quantitative” method to differentiate “normal” functioning cardiac tissue from non-viable “infarcted” cardiac tissue, from “stunned/hibernating” myocytes.
12/18/14
20140371326

Food composition for preventing obesity, pharmaceutical composition for treating obesity, and animal medicine for treating obesity, containing gingernone a


Disclosed is a composition comprising gingerenone a as an active ingredient. The composition includes a food composition for preventing obesity, a pharmaceutical composition for treating obesity and a medicine for treating animal obesity.
Snu R&db Foundation
12/18/14
20140371271

Novel piperine derivatives and uses thereof


The present invention provides novel piperine derivatives. The present pharmaceutical or food composition containing a piperine derivative as an active ingredient is very effective in preventing or treating metabolic diseases including obesity, diabetes, dyslipidemia, fatty liver and insulin resistance syndrome.
Industry-academic Cooperation Foundation, Yonsei University
12/18/14
20140371143

New peptide inhibiting rankl-rank interaction and the use thereof


Provided are a peptide for inhibiting an interaction between an rankl and an rank consisting of an amino acid sequence of seq id no: 1 and a pharmaceutical composition for preventing or treating bone diseases including the peptide. The peptide consisting of an amino acid sequence of seq id no: 1 is not present in a cyclic shape, and has 10 or less amino acids, thereby having better biostability than a conventional peptide to inhibit an rankl-rank interaction, being preferable in price during synthesis, and having a better rankl-rank interaction inhibitory effect.
Research & Business Foundation Sungkyunkwan University
12/18/14
20140371058

Catalyst structure for treating exhaust gas


Provided is a novel catalyst structure capable of maintaining gas diffusivity to a deep part of a catalyst layer even under condition of a high gas flow rate. Proposed is a catalyst structure, which has a porous apatite catalyst layer containing an oxide (hereinafter referred to as “apatite”) whose crystalline structure belongs to an apatite type, and in which, in logarithmic differentiation void volume distribution measured by a mercury intrusion porosimeter, a peak top is present within a void volume diameter range of 100 nm to 1000 nm..
Mitsui Mining & Smelting Co., Ltd.
12/18/14
20140370600

Method of preparing mesenchymal stem cell basic culturing medium, making of cellular therapy product with mesenchymal stem cell basic culturing medium, and the differentiated one by using the medium


Disclosed is a basic culture medium for mesenchymal stem cells, and a cell therapeutic agent cultured and differentiated using same. The basic culture medium reduces the time taken from collection to mass culturing by increasing the proliferation rate of undifferentiated mesenchymal stem cells derived from an adult tissue such as human marrow and adipose tissue, and also is capable of various differentiations into treating agents for bone-forming cells, for cartilage cells, or for fat cells..
Sewon Cellontech Co., Ltd.
12/18/14
20140370598

Articles and methods for stem cell differentiation


Articles and methods for stem cell differentiation are generally described. In some embodiments, an article for stem cell differentiation may comprise an oxygen permeable substrate having at least a portion of a surface coated with a matrix.
Massachusetts Institute Of Technology
12/18/14
20140370537

Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells


The present invention provides a method of producing a skeletal muscle cell from a pluripotent stem cell, which includes a step of expressing one or more exogenous factors selected from myod, myf5 and nucleic acids encoding them on a pluripotent stem cell.. .
Kyoto Universtiy
12/18/14
20140370007

Method of directed differentiation producing corneal endothelial cells, compositions thereof, and uses thereof


This disclosure generally relates to cell-based therapies for treatment of visual disorders, including disorders of the cornea. Methods are exemplified for directed differentiation of corneal cells from stem cells.
Advanced Cell Technology, Inc.
12/18/14
20140369999

Screening method


This invention relates to a novel screening method that identifies simple molecular markers that are predictive of whether a particular disease condition is responsive to a specific treatment. Also, a method of diagnosing the susceptibility of an individual suffering from a disease to treatment with an hdac inhibitor is provided.
Isis Innovation Limited
12/18/14
20140369998

Biomarkers for tuberculosis and hiv/aids


Described herein is a diagnostic test that identifies circulating biomarkers for the differentiation and classification of the pathogenesis of tb and/or hiv in a population.. .
12/18/14
20140369976

Method to amplify cardiac stem cells in vitro and in vivo


Compositions comprising stem cells delivered into infarcted myocardium by endocardial injection, engraft and differentiate into myocytes, endothelial cells, and vascular smooth muscle, and do so without the requirement for survival enhancing modification. These cells engraft whether injected acutely (days) or late (months) after myocardial infarction, and the efficiency of engraftment correlates with the functional recovery of the heart.
Vestion, Inc.


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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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