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This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS


Date/App# patent app List of recent Differentiation-related patents
04/16/15
20150105299
 Method for differentiation of polynucleotide strands patent thumbnailnew patent Method for differentiation of polynucleotide strands
Objective of the present invention is to provide a method for keeping of directional information in double-stranded dna. We suggest to convert polynucleotide into a hybrid double-stranded dna.
Max-planck-gesellschaft Zur Forderung Der Wissenschaften E.v.
04/16/15
20150104879
 Composition for diagnosing liver cancer and methods of diagnosing liver cancer and obtaining information for diagnosing liver cancer patent thumbnailnew patent Composition for diagnosing liver cancer and methods of diagnosing liver cancer and obtaining information for diagnosing liver cancer
Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to transmembrane emp24 domain trafficking protein 2 (tmed2), cluster of differentiation 43 (cd43), or any combination thereof on the surface of a microvesicle; and measuring the level of the substance bound to microvesicles in the sample; and related methods and compositions.. .
Samsung Electronics Co., Ltd.
04/16/15
20150104870
 Neuronal differentiation promoter patent thumbnailnew patent Neuronal differentiation promoter
The present invention provides an agent for promoting neuronal differentiation of neural stem cells, which contains a p38 inhibitor. In addition, the present invention provides a method of promoting neuronal differentiation of neural stem cells, which includes cultivating neural stem cells in the presence of a p38 inhibitor.
Keio University
04/16/15
20150104431
 Cardiac muscle repair or regeneration using bone marrow-derived stem cells patent thumbnailnew patent Cardiac muscle repair or regeneration using bone marrow-derived stem cells
Disclosed are compositions and methods for repairing and/or regenerating cardiac tissue by administering adult bone marrow-derived stem cells to an individual. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid.
Mesoblast International Sarl
04/16/15
20150104430
 Methods and compositions for generating pancreatic progenitors and functional beta cells from hpscs patent thumbnailnew patent Methods and compositions for generating pancreatic progenitors and functional beta cells from hpscs
Methods and compositions for producing nkx6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an egf component, a nicotinamide component and/or a noggin component, optionally a combination of at least one egf component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a nkx6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one noggin component.. .
University Health Network
04/16/15
20150104429
 Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression patent thumbnailnew patent Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression
Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided. Furthermore, the present invention provides methods for producing a cell, such as a stem or progenitor cell, with induced gene expression by contacting a stem or progenitor cell with an effective amount of a synthetic triterpenoid to induce the expression of one or more of sox9 (sex determining region y-box 9), col2a1 (type ii collagen (alpha1)), tgf-βi, tgf-p2, tgf-33, bmp2, bmp4, bmprii (bone morphogenic protein receptor ii), smad (small mothers against decapentaplegic) 3, smad4, smad6, smad7, timp (tissue inhibitor of metalloproteinase)-1 or timp-2 in the stem or progenitor cell, wherein the stem or progenitor cell is not a mesenchymal stem cell, periosteium cell or osteoprogenitor cell.
Trustees Of Dartmouth College
04/09/15
20150101009
 Method for providing access of an user end device to a service provided by an application function within a network structure and a network structure patent thumbnailMethod for providing access of an user end device to a service provided by an application function within a network structure and a network structure
For allowing a simple and reliable differentiation of ues behind a gw from an af side a method for providing access of an user end device (ue) to a service provided by an application function (af) within a network structure is claimed, wherein the ue is authenticated by a gateway (gw) to which the ue is attached and which provides access to the af via a broadband access network (bb access network). The method is characterized in that the gw informs a state database (sdb) on service flow requests to or from the authenticated ue towards the af, that the gw additionally sends nat (network address translation) or napt (network address and port translation) binding information of a respective nat or napt binding created by the gw regarding the authenticated ue and a respective service flow request to the sdb and that the sdb sends the nat or napt binding information or an ue identifier to the af, so that the af—after having received the service flow request from the gw—can correlate the authenticated ue with the service flow request.
Nec Europe Ltd.
04/09/15
20150099964
 System and  differentiation of normal myocardium from diffuse disease using t1 mapping in non-ischemic cardiomyopathies and others patent thumbnailSystem and differentiation of normal myocardium from diffuse disease using t1 mapping in non-ischemic cardiomyopathies and others
A method for differentiation of normal myocardium from diffuse disease using t mapping includes acquiring one or more images of a patient by an imaging apparatus, generating a t1 map from the one or more images, defining a region of interest within the one or more images, determining the average t1 value within the region of interest, comparing the average t1 value within the region of interest to a cut-off t1 value, and determining a diagnosis of the region of interest from the comparison.. .
Koninklijke Philps N.v.
04/09/15
20150099666
 Method and device for combined detection of viral and bacterial infections patent thumbnailMethod and device for combined detection of viral and bacterial infections
A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections.
Rapid Pathogen Screening, Inc.
04/09/15
20150099300
 Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair patent thumbnailUse of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair
Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration.
Artecel Sciences Inc.
04/09/15
20150099296

Promoter-regulated differentiation-dependent self-deleting cassette


Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell.
Regeneron Pharmaceuticals, Inc.
04/02/15
20150094277

Combination therapy and methods for treatment and prevention of hyperproliferative diseases


The present invention provides therapy and methods for the treatment and prevention of diseases of cell proliferation such as cancer, benign tumors, and viral diseases such as hiv-aids, hepatitis b, hepatitis c and cirrhosis. The methods of this invention consist of the administration to a patient of a combination of effective amounts of agents capable of eradicating the neoplastic cells, while sparing the non-neoplastic cells from cytotoxic side-effects.
04/02/15
20150093828

Cell culturing article and manufacturing thereof


The disclosure provides a cell culturing article. The cell culturing article includes a substrate having a surface, a hydrophilic copolymer layer positioned on the surface of the substrate, and a plurality of peptide chains individually conjugated to a surface of the hydrophilic copolymer layer.
National Central University
04/02/15
20150093363

Osteogenic differentiation of mesenchymal stem cells


The present invention relates to a method for inducing and/or promoting osteogenic differentiation using extracellular vesicles and the use thereof.. .
Biomatcell Ab
04/02/15
20150092916

Material differentiation with phase contrast imaging


A method and system to determine material composition of an object comprises capturing a series of digital radiographic images of the object using a single exposure energy level. An intensity of the captured images is determined as well as phase shift differences.
Carestream Health, Inc.
03/26/15
20150087790

Polycarbonate containing compounds and methods related thereto


Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The cross-linked polycarbonates can be prepared from allyl or epoxy polycarbonates.
Vanderbilt University
03/26/15
20150087062

System and electrospun biodegradable scaffold for bone repair


This invention relates a structure and system for growth factor incorporation which can improve the osteogenic differentiation of hmscs, for potential bone regeneration and bone growth applications or used alone for bone repair or growth applications. The system comprises a biodegradable polyester, a hydrophilic polymer, a growth factor and optionally a bioceramic..
03/26/15
20150087060

Method for inducing erythropoietin-producing cell


An object of the present invention is to provide a method for inducing the differentiation of erythropoietin-producing cells from human pluripotent stem cells. The above object is achieved by providing a method for inducing the differentiation of erythropoietin-producing cells from human pluripotent stem cells using a medium containing a specific growth factor and a specific compound..
Kyoto University
03/26/15
20150086989

Methods and nucleic acids for analyses of cellular proliferative disorders


Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients..
Epigenomics Ag
03/26/15
20150086636

Myostatin inhibition for enhancing muscle and/or improving muscle function


The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving muscle function (including decreasing atrophy and/or increasing endurance, force and/or strength). Some of the methods involve delivering genes to cells using gene delivery or other delivery techniques known in the art in order to inhibit myostatin.
Nationwide Children's Hospital
03/26/15
20150086511

Survival, differentiation and structural integration of human neural stem cells grafted into the adult rat spinal cord


The present invention provides methods and compositions for treating spinal cord diseases and injuires. The methods involve transplanting neural stem cells which have been previously expanded in vitro into a patient such that the cells can ameliorate the disease or injury.
The Johns Hopkins University
03/26/15
20150086508

Compositions and methods for enhancing epidermal repair and cutaneous innate immunity


The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair.
03/19/15
20150081018

Methods and substrates for differentiation of neural stem cells


The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons.. .
Rutgers, The State University Of New Jersey
03/19/15
20150080770

Differentiation of stem cells with nanoparticles


This invention relates to stimulation of stem cells and other progenitors of differentiated cells using nanoparticles and electromagnetic stimulation. The invention provides a method for differentiating mesenchymal stem cells (mscs) towards osteoblasts and other connective tissue.
The Research Foundation For The State University Of New York
03/19/15
20150079153

Cell suspension and use thereof


The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for promoting tissue regeneration in an epithelium-related procedure, as well as compositions produced therefrom. The cellular suspension can include viable and functioning cells at various stages of differentiation, including undifferentiated/progenitor cells and differentiated cells, as well as those in between.
Avita Medical Ltd.
03/19/15
20150079143

Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices


Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described.
Drexel University
03/19/15
20150077383

Multiple bridges single sided touch sensor


A touch sensor panel can include a plurality of drive lines crossing a plurality of sense lines, forming an array. The plurality of drives lines and the plurality of sense lines can be formed by interconnecting sections of at least one conductive material with a plurality of bridges.
Apple Inc.
03/19/15
20150075260

Fueling system vapor recovery and containment performance monitor and operation thereof


A method and apparatus for monitoring and determining fuel vapor recovery performance is disclosed. The dispensing of liquid fuel into a tank by a conventional gas pump nozzle naturally displaces a mixture of air and fuel ullage vapor in the tank.
Veeder-root Company
03/12/15
20150072935

Composition and external application for acceleration of muscle differentiation and improving of muscle mass


Provided are a composition and an external application for promoting muscle differentiation or improving muscle mass containing an amino acid derivative promoting muscle cell differentiation, a composition and an external application for alleviating muscle function deterioration caused by muscle damage and recovering damaged muscle containing the same, or a pharmaceutical composition and an external application for treating or improving a muscle deterioration disease containing the same.. .
Neopharm Co., Ltd.
03/12/15
20150072427

Dedifferentiation and reprogramming of cells


The invention is directed to methods for reprogramming somatic cells to a less differentiated state. In particular, the invention is directed to methods for reprogramming amnion epithelial cells (aec) including amnion-derived cells (adc) and amnion-derived multipotent progenitor cells (amp cells) to a less differentiated state.
Stemnion, Inc.
03/12/15
20150072425

Methods of generating natural killer cells


Provided herein are methods of producing natural killer cells using a two-step expansion and differentiation method. Also provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising administering the nk cells produced by the method to an individual having the cancer or viral infection..
Anthrogenesis Corporation
03/12/15
20150071330

Spread spectrum non-linear junction detector


A digital spread spectrum non-linear junction detector (nljd) utilizes the 2.4 ghz transmission band to increase sensitivity to detect smaller electronics. The receiver chain of the nljd pre-distorts the transmission signal and correlates the result with the response signal to differentiate between target responses and ambient interference signals.
03/12/15
20150070284

Method for differentiation of touch input and visualization of pending touch input


An apparatus and method for differentiation of a touch input in a touch sensitive device are provided. The method includes extending an object of a plurality of objects, each of the plurality of objects having a different corresponding identity, determining an identity of the extended object, communicating the identity of the extended object to the touch sensitive device, and, when the object touches the touch sensitive device, performing a function of the touch sensitive device according to the identity of the extended object..
Samsung Electronics Co. Ltd.
03/12/15
20150070156

Object differentiation warning system


A vehicle object warning system and method that differentiates between expected and unexpected objects. A sensor detects a set of objects external to the vehicle upon the occurrence of different triggering conditions.
Robert Bosch Gmbh
03/05/15
20150065427

Modulation of osteoclast differentiation


Provided are methods for treating a pathological condition associated with unbalanced osteoclast differentiation by providing an aqp-9 modulator. The modulator can be an aqp-9 inhibitor or an aqp-9 inducer.
Osteobuild Ltd.
03/05/15
20150065359

Culture based screening assay and methods of use thereof to identify agents which modulate tumor development, invasion and differentiation


A 3d organotypic culture which phenocopies aggressive, invasive cancer and methods of use thereof are provided.. .
The Trustees Of The University Of Pennsylvania
03/05/15
20150065276

Asymmetric basketball net to support ball return


The present invention is a basketball net designed to facilitate preferred directional momentum to an exiting basketball. The basketball net is designed and constructed in a manner such that the basketball exiting the net has desired exit-trajectory and rotational spin.
03/05/15
20150064734

Method for screening therapeutic and/or prophylactic agents for alzheimer's disease


The present invention provides a method for screening a therapeutic and/or prophylactic agent for alzheimer's disease using at least one index selected from the group consisting of the levels of aβ oligomers, bip, cleaved caspase 4, prdx4 and ros in nerve cells or the like whose differentiation has been induced from ips cells derived from somatic cells of a patient with alzheimer's disease.. .
Kyoto University
03/05/15
20150064141

Regenerative sera cells and mesenchymal stem cells


Disclosed herein are three types of skin-derived cells. One type of the cells is mesenchymal stem cells characterized by expression of the cell surface biomarker cluster of differentiation (cd) 146, the second type expresses cd271.
The Regents Of The University Of California
03/05/15
20150064109

Quantified differentiation and identification of changes in tissue by enhancing differences in blood flow and metabolic activity


The invention provides a novel quantitative method for differentiating and identification of changes in tissue by enhancing differences in blood flow prior to administering a radiopharmaceutical, which differentially accumulates in tissue based upon differences in blood flow and metabolic activity. In one embodiment the enhancing agent is 0.852 mg per kilogram body weight dipyridamole and the radiopharmaceutical is technetium-99m hexakis 2-methoxyisobutylisonitrile (sestamibi) and the tissue differentiation is calcification, normal, inflammatory, precancerous and cancerous breast tissue.
02/26/15
20150058388

Fractional scaling digital filters and the generation of standardized noise and synthetic data series


Generation of standardized noise signals that provide mathematically correct noise with no errors and no loss of data, and can generate the noise of specific environments based on the transfer function of that environment are discussed. Various embodiments can generate synthetic data sets based on natural data sets that have similar scaling behavior.
Wright State University
02/26/15
20150057184

Cellular microarrays for screening differentiation factors


Provided is a microarray platform for the culture of cells atop combinatorial matrix mixtures; enabling the study of differentiation in response to a multitude of microenvironments in parallel.. .
The Regents Of The University Of California
02/26/15
20150057172

Real-time pcr detection of mycobacterium tuberculosis complex


The present invention relates to assays, diagnostic kits and methods for the simultaneous real-time pcr detection of bacteria belonging to the mtr and/or mycobacterium tuberculosis and methods, compositions, kits and assays allowing differentiation between mtc species other than mycobacterium tuberculosis.. .
Vela Operations Pte. Ltd.
02/26/15
20150056628

Detection and typing of bacterial strains


Methods for the detection and typing of bacterial strains from food products and dietary supplements, environmental samples, in vivo/in vitro samples, and for studying the natural diversity of the species are disclosed. Potential applications also include product development and/or detection and differentiation of new bacterial strains..
Danisco A/s
02/26/15
20150056173

Beta cell growth and differentiation


The invention includes methods that can be used to increase β cell populations in vivo and in vitro, useful in the treatment of diabetes and related disorders.. .
The Regents Of The University Of California
02/19/15
20150051484

Histological differentiation grade prediction of hepatocellular carcinoma in computed tomography images


A method of determining the histological grade of hepatocellular carcinoma (hcc) including: acquiring a computed tomography (ct) image of a person including an hcc tumor; delineating the hcc tumor; and assigning a histological grade to the hcc tumor, wherein assigning the histological grade to the hcc tumor includes: applying a plurality of filters to the hcc tumor, wherein each of the filters produces a corresponding response image and, for each of the filters, a convolution operation is performed on the filter and the ct image to produce the response image corresponding to that filter; computing an average response of the hcc tumor in each of the response images and recording each of the average responses as an independent subspace analysis (isa) feature; and determining the histological grade of the hcc tumor based on the isa features by using a classifier.. .
Siemens Aktiengesellschaft
02/19/15
20150051156

Method of treating leukemia using rice prolamin


The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (pbmc) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells.
Mackay Memorial Hospital
02/19/15
20150050732

Selective differentiation, identification, and modulation of human th17 cells


The embodiments provide for the modulation of both the differentiation and activity of human th17 cells. More specifically, human th17 cell differentiation can modulated by tgf-β and il-21, and their agonists and antagonists.
The Brigham And Women's Hospital, Inc.
02/19/15
20150050239

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
02/12/15
20150045299

Tgfb type ii-type iii receptor fusions


Certain embodiments are directed to novel heterotrimeric fusions in which the ectodomain of the tgf-β type ii receptor (tβp?ii) is coupled to the n- and c-terminal ends of the endoglin-domain of the tgf-β type iii receptor (tpriiie). Certain embodiments are directed to novel heterotrimeric polypeptides in which the ectodomain of the tgf-β type ii receptor (ti3rii) is coupled to the n- and c-terminal ends of the endoglin-domain (e domain) of the tgf-β type iii receptor (ti3riii).
The Board Of Regents Of The University Of Texas System
02/12/15
20150045297

Growth differentiation factor (gdf) for treatment of diastolic heart failure


The technology described herein relates to treatments for, e.g., diastolic heart failure, cardiac hypertrophy, and related conditions.. .
President And Fellows Of Harvard College
02/12/15
20150044770

Method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays


The present invention relates to a method for selective cell attachment/detachment, cell patternization and cell harvesting by means of near infrared rays. More particularly, conducting polymers or metal oxides having exothermic characteristics upon irradiation of near infrared light is used as a cell culture scaffold, thus selectively attaching/detaching cells without an enzyme treatment.
Industry-academic Cooperation Foundation Yonsei University
02/12/15
20150044752

Method of treatment of mesenchymal stem cells


Extracted human mesenchymal cells (mscs) are placed into the interior space of a closed vessel and exposed to an electric ac current and/or electromagnetic field. The mscs are also stirred within the vessel to further stimulate the cells, enhancing the osteodifferentiation process during human transplantation of the cells..
02/12/15
20150044663

Technique for regulating regeneration of tissue or faulty or abnormal part in organ using nell-1


The object aims to form and maintain a cell, a tissue or an organ induced by differentiation. Disclosed is a composition for inducing the differentiation of a cell capable of being differentiated in a given direction to thereby produce a cell, a tissue or an organ through the further induction of the differentiation in the given direction.
Showa University
02/05/15
20150038400

Compositions, the preparation and use thereof


The present teachings provide new compositions comprising polycations and polycations, and the preparation and use of these new compositions. In one aspect, the new compositions are complex coacervates.
Kci Licensing, Inc.
02/05/15
20150037883

Method for derivation and long-term establishment of ground state pluripotent embryonic stem cells


The various embodiments herein provide a method for derivation and long term establishment of ground state pluripotent embryonic stem cells. Further the embodiments herein provides a method to inhibit the erk and tgf β signalling pathways for long term maintenance of the embryonic stem cells.
Royan Institute
02/05/15
20150037290

Methods of modulating smooth muscle cell proliferation and differentiation


The present disclosure provides methods of inducing smooth muscle cell differentiation. The present disclosure provides genetically modified cells comprising exogenous mir-143 and/or mir-145 nucleic acids; and artificial tissues comprising the genetically modified cells.
The J. David Gladstone Institutes
02/05/15
20150037280

Substituted pyrazolone compounds and methods of use


The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Calitor Sciences, Llc
02/05/15
20150036371

Mirror a vehicle


A mirror apparatus for a vehicle includes a design body, a first emission member, a second emission member, a guide body and a differentiation portion. The design body includes a mirror provided at a vehicle, and the design body structures a design surface.
Toyota Jidosha Kabushiki Kaisha
02/05/15
20150033620

Mycological biopolymers grown in void space tooling


A mycological biopolymer product consisting entirely of fungal mycelium is made by inoculating a nutritive substrate with a selected fungus in a sealed environment except for a void space, which space is subsequently filled with a network of undifferentiated fungal mycelium. The environmental conditions for producing the mycological biopolymer product, i.e.


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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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