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Differentiation patents



      
           
This page is updated frequently with new Differentiation-related patent applications. Subscribe to the Differentiation RSS feed to automatically get the update: related Differentiation RSS feeds. RSS updates for this page: Differentiation RSS RSS


Date/App# patent app List of recent Differentiation-related patents
05/21/15
20150141463
 Substituted pyrazolone compounds and methods of use patent thumbnailnew patent Substituted pyrazolone compounds and methods of use
The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans..
Sunshine Lake Pharma Co., Ltd.
05/21/15
20150141430
 Method for modulating canonical wnt pathway using folate and inositol patent thumbnailnew patent Method for modulating canonical wnt pathway using folate and inositol
The canonical wnt signaling pathway is implicated in wound healing. Administration of a composition having myo-inositol and folic acid upregulates fibronectin and provides the greatest protection in an additive/synergistic manner against adverse wnt/β-catenin-mediated effects on cell processes relating to cell differentiation, proliferation, and migration that relate to wound healing..
University Of South Florida
05/21/15
20150141352
 Bone loss preventing and bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide patent thumbnailnew patent Bone loss preventing and bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide
The present invention relates to a bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide, an analogue thereof, a derivative thereof or a pharmaceutically acceptable salt thereof. In contrast to existing passive therapeutic agents which center on bone absorption suppression based on mechanisms for reducing osteoclast functionality, the composition comprising muramyl dipeptide of the present invention promotes the differentiation of osteoblasts, which are bone forming cells, and can advantageously be used in various diseases where bone formation is required as an active therapeutic agent that does not affect osteoclast..
Snu R&db Foundation
05/21/15
20150141289
 Methods and compositions for identifying and validating modulators of cell fate patent thumbnailnew patent Methods and compositions for identifying and validating modulators of cell fate
The invention provides for compositions and methods for identifying and validating modulators of cell fate, such as such as maintenance, cell specification, cell determination, induction of stem cell fate, cell differentiation, cell dedifferentiation, and cell trans-differentiation. The invention relates to reporter nucleic acid constructs, host cells comprising such constructs, and methods using such cells and constructs.
Chromocell Corporation
05/21/15
20150141268
 Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens patent thumbnailnew patent Active-source-pixel, integrated device for rapid analysis of biological and chemical specimens
An active-source-pixel, integrated device capable of performing biomolecule detection and/or analysis, such as single-molecule nucleic acid sequencing, is described. An active pixel of the integrated device includes a sample well into which a sample to be analyzed may diffuse, an excitation source for providing excitation energy to the sample well, and a sensor configured to detect emission from the sample.
Quantum-si Incorporated
05/21/15
20150140661
 Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter patent thumbnailnew patent Method for producing pancreatic hormone-producing cell, pancreatic hormone-producing cell, and differentiation/induction promoter
The method for producing a pancreatic hormone-producing cell according to the present invention is characterized in that a specific differentiation/induction promoter is added to a culture medium in the process of differentiating/inducing of a pluripotent stem cell or a pancreatic tissue stem/progenitor cell into the pancreatic hormone-producing cell. The differentiation/induction promoter to be used is: a polypeptide which comprises an amino acid sequence encoded by dna comprising the nucleotide sequence represented by seq id no: 1 or a variant thereof; or a culture supernatant of a cell into which dna comprising the nucleotide sequence represented by seq id no: 1 or dna capable of hybridizing with dna comprising a nucleotide sequence complementary to the aforementioned dna under stringent conditions is integrated as a foreign gene..
Saitama Medical University
05/21/15
20150140658
 Lineage reprogramming to induced cardiac progenitor cells (icpc) by defined factors patent thumbnailnew patent Lineage reprogramming to induced cardiac progenitor cells (icpc) by defined factors
Animal cells, notably adult fibroblasts, are advantageously reprogrammed in direct lineage reprogramming methods using defined factors to produce proliferative and multipotent induced cardiac progenitor cells (icpc). The icpc thus produced can be differentiated under suitable differentiation conditions to cardiac lineage cells including cardiomyocytes, smooth muscle cells, and endothelial cells, as evidenced by expression of lineage specific markers.
Wisconsin Alumni Research Foundation
05/21/15
20150140123
 Protein expression analyses for identifying genotoxic compounds patent thumbnailnew patent Protein expression analyses for identifying genotoxic compounds
The invention relates to a method for screening compounds with (pro-)genotoxic activity by providing a system being capable of expressing a panel of defined proteins, incubating at least a portion of the system with compounds to be screened, and comparing the expression of the proteins in the system with the protein expression in a control system, thereby detecting the (pro-)genotoxic activity. Another object of the invention concerns a method for monitoring the likelihood of developing a physiological and/or pathological condition, which is caused, mediated and/or propagated by the genetic deregulation of proliferation, differentiation and/or damage repair, in response to a compound administered to a mammal in need of such treatment by determining an expression level of defined proteins in a biological sample withdrawn from the mammal.
Merck Patent Gmbh
05/21/15
20150140016
 Molecular determinants of myeloma bone disease and uses thereof patent thumbnailnew patent Molecular determinants of myeloma bone disease and uses thereof
The present invention is drawn to understanding lytic bone diseases. In this regard, the present invention discloses mechanism by which wnt signaling antagonist inhibits bone differentiation.
Board Of Trustees Of The University Of Arkansas
05/21/15
20150139982
 Anti-siglec-15 antibodies patent thumbnailnew patent Anti-siglec-15 antibodies
Antibodies and antigen binding fragments that specifically binds to siglec-15 are described herein. These antibodies or antigen binding fragments may have the ability of inhibiting differentiation of osteoclasts and/or the ability of inhibiting the bone resorption activity of osteoclasts.
Alethia Biotherapeutics Inc.
05/21/15
20150139978
new patent

Novel monascuspurpurones, preparation process thereof, and uses of the monascuspurpurones


Or a pharmaceutically acceptable derivative thereof as described in the specification, the process for preparation of the same, and the composition comprising the same. The uses of a monascuspurpurone compound for promoting adipocyte differentiation, for increasing the activity of pparγ and/or c/ebpα, for lowering blood glucose, for preventing and/or treating a disease or disorder related to insulin resistance, and for preventing and/or treating metabolic syndrome or its complications are also provided..
05/21/15
20150136430
new patent

Fire suppression systems, devices, and methods


Systems, devices, and methods for determining whether a fire condition exists based on a status of a cooking appliance, and systems, devices, and methods for controlling an exhaust air flow rate in an exhaust air ventilation system based on the status of the cooking appliance. At least one sensor type generating a predefined signal is used to detect fire condition and appliance cooking state, the predefined signal being applied to a controller which differentiates, responsively the predefined signal, in combination with other sensor signals, at least two cooking states each of the cooking states corresponding to at least two exhaust flow rates which the controller implements in response to the controller's differentiation of the two states and which predefined signal is simultaneously used to differentiate a fire condition, in response to the differentiation of which, the same controller activates a fire suppression mechanism..
Oy Halton Group Ltd.
05/14/15
20150134412

Tools and methods for differentiating child-liking scores in product testing environments


The present disclosure provides tools and methods for improving differentiation in child-liking scores in a product testing environment and/or to improve development of products for child consumers. In an embodiment, tools for differentiating market research scores are provided and include a product rating scale having a plurality of successive scale points and a verbal anchor corresponding to each scale point, and a behavioral list with a plurality of product acceptance behaviors.
05/14/15
20150133520

Compositions and methods for inducing myoblast differentiation and myotube formation


Provided herein are methods of inducing differentiation of a mammalian myoblast into a mammalian myocyte that include contacting a mammalian myoblast with an oligonucleotide that decreases mitogen-activated protein kinase kinase kinase kinase 4 (map4k4) mrna expression in a mammalian myoblast or myocyte. Also provided are methods of inducing mammalian myoblasts or myocytes to form a myotube that include contacting two or more mammalian myoblasts or two or more mammalian myocytes with an oligonucleotide that decreases map4k4 mrna expression in a mammalian myoblast or myocyte.
05/14/15
20150132853

Cytoplasmic transfer to de-differentiate recipient cells


Methods for de-differentiating or altering the life-span of desired “recipient” cells, e.g., human somatic cells, by the introduction of cytoplasm from a more primitive, less differentiated cell type, e.g., oocyte or blastomere are provided. These methods can be used to produce embryonic stem cells and to increase the efficiency of gene therapy by allowing for desired cells to be subjected to multiple genetic modifications without becoming senescent.
05/14/15
20150132847

Encapsulation and cardiac differentiation of hipscs in 3d peg-fibrinogen hydrogels


The present invention relates to the production of cell cultures and tissues from undifferentiated pluripotent stem cells using three-dimensional biomimetic materials. The resultant cell cultures or tissues can be used in any of a number of protocols including testing chemicals, compounds, and drugs.
05/14/15
20150132846

Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof


The present invention relates to methods for production of undifferentiated or differentiated embryonic stem cell aggregate suspension cultures from undifferentiated or differentiated embryonic stem cell single cell suspensions and methods of differentiation thereof.. .
05/14/15
20150132355

Tdf-related compounds and analogs thereof


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules which act as functional modulators of tdf-like receptors.
05/07/15
20150126884

System for heart performance characterization and abnormality detection


A system improves analysis, diagnosis and characterization of cardiac function signals (including surface ecg signals and intra-cardiac electrograms) based on cardiac electrophysiological activity momentum computation, characterization and mapping. The system calculates an electrophysiological signal momentum of different portions of cardiac signals including a timing, location and severity of cardiac pathology and improves reliability of diagnosis, detection, mapping to an identified medical condition, and characterization.
Siemens Medical Solutions Usa, Inc.
05/07/15
20150126451

Tdf-related compounds and analogs thereof, analogs and bioactive fragments


The present invention relates generally to tissue differentiation factor (tdf) analogs. More specifically, the invention relates to structure-based methods and compositions useful in designing, identifying, and producing molecules, which act as functional modulators of tdf-like receptors.
Thrasos Innovation, Inc.
05/07/15
20150125958

Methods for controlling stem cell differentiation


Disclosed herein are methods for controlling stem cell differentiation through the introduction of transgenes having xic, tsix, or xite sequences to block differentiation and the removal of the transgenes to allow differentiation. Also disclosed are small rna molecules and methods for using the small rna molecules to control stem cell differentiation.
The General Hospital Corporation
05/07/15
20150125953

Methods for generating the inner ear and other cranial placode-derived tissues using pluripotent stem cells


Disclosed herein are methods and compositions for generating cultures and isolated cell populations containing preplacodal ectoderms cells, otic placode cells, and inner ear sensory hair cells derived from pluripotent cells by modulating tgfβ, bmp, and fgf signaling pathways under defined culture conditions. Also described are methods for obtaining non-otic placodal tissues from pluripotent stem cells.
Indiana University Research & Technology Corporation
05/07/15
20150125506

Retinal pigment epithelial cells differentiated from embryonic stem cells with nicotinamide and activin a


The present invention concerns rpe cells obtainable by directed differentiation from stem cell, particularly, human stem cells. It has been specifically found that culturing stem cells in the presence of one or more member of the tgfβ superfamily, such as activin a) induced directed differentiation into mature and functional rpe cells.
Hadasit Medical Research Services And Development Ltd.
05/07/15
20150125430

Compositions and methods for inducing thrombopoiesis


Methods of inducing thrombopoiesis and/or treating thrombocytopenia in a subject are provided. Accordingly there is provided a method comprising contacting stem cells with a differentiation potential towards platelets or hematopoietic progenitor cells derived therefrom with livin, thereby inducing thrombopoiesis.
Hadasit Medical Research Services And Development Ltd.
04/30/15
20150119326

Administration of angiocidin for the treatment of cancer


Methods are presented for the therapeutic administration of angiocidin in the treatment of cancers such as glioma, breast cancer, and leukemia. Methods are also presented for inducing growth arrest and/or apoptosis of tumor cells, as well as inducing differentiation of tumor cells to inhibit tumorigenicity and to confer a non-tumor or healthy phenotype..
Temple University Of The Commonwealth Of Higher Education
04/30/15
20150118749

Retinal pigment epithelial cells differentiated from embryonic stem cells with nicotinamide and activin a


The present invention concerns rpe cells obtainable by directed differentiation from stem cell, particularly, human stem cells. It has been specifically found that culturing stem cells in the presence of one or more member of the tgfβ superfamily, such as activin a) induced directed differentiation into mature and functional rpe cells.
Hadasit Medical Research Services And Development Ltd.
04/30/15
20150118200

Production of extracellular matrix, conditioned media and uses thereof


Provided is a matrix for promoting survival and differentiation of cells transplanted thereon, comprising a base matrix and a cell-made matrix thereon. Methods and means for making and using same are also provided.
Rutgers, The State University Of New Jersey
04/23/15
20150113545

Modified jvm with multi-tenant application domains and class differentiation


A method and system for operating a modified java virtual machine (jvm) which is able to simultaneously host multiple java application programs is disclosed. In a first modification the jvm is modified to permit multiple class definitions of some of the java application programming interface (api) classes, so called non-sensitive classes, to be loaded multiple times but ea) restrict other java api classes, so called sensitive classes, to be loaded only once, preferably onto a bootstrap class loader.
Waratek Limited
04/23/15
20150113415

Method and determining user interface


A method and an apparatus for determining a user interface, which can ensure that a user interface is applicable to a terminal device, and meets a differentiation requirement of the terminal device on a user interface presentation form. The method includes: receiving terminal information sent by a terminal device, where the terminal information includes terminal capability information; determining a first user interface according to the terminal information; and sending the first user interface to the terminal device.
Huawei Technologies Co., Ltd.
04/23/15
20150111828

Dipeptide mimetics of ngf and bdnf neurotrophins


The invention relates to compounds having either agonist or antagonist activities for the neurotrophins ngf and bdnf and represented by monomeric or dimeric substituted dipeptides that are analogs of the exposed portions of loop 1 or loop 4 regions of these neurotrophins near or at a beta-turn of the respective loop. N-acylated substituents of these dipeptides are biostereoisomers of the amino acid residues preceding these dipeptide sequences in the neurotrophin primary structure.
Uchrezhdenie Rossiiskoi Akademii Meditsynskikh Nauk Nauchno-issledovatelsky Institut Farmakologii
04/23/15
20150111225

Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof


The present invention relates to a method for in vitro differentiation of a population of blood circulating cells, such as monocytes and preferably pluripotent macrophages derived therefrom, into cells displaying functional and phenotypic neuronal characteristics. The invention further encompasses neuronal-like cells obtainable according to the present method, compositions comprising said cells, and applications thereof..
Assistance Publique - Hopitaux De Paris
04/23/15
20150111218

Cell differentiation assay method, cell isolation method, producing induced pluripotent stem cells, and producing differentiated cells


Provided are a method for accurately evaluating the differentiation status of stem cells by selectively staining only stem cells in an undifferentiated state, and a method for positively isolating only stem cells in an undifferentiated state. Specifically provided is a method for determining differentiation of a cell comprising a step of contacting a test cell with a probe comprising protein (a) or (b) below and a step of detecting the presence of binding of the probe to the test cell.
Wako Pure Chemical Industries, Ltd.
04/23/15
20150111209

Gene amplification of coactivator coaa and uses thereof


It has been discovered that amplifications in the gene coactivator activator (coaa) blocks stem cell differentiation and induces cancer stem cells. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to gene amplifications in coaa.
04/23/15
20150110835

Turkey herpesvirus vectored recombinant containing avian influenza genes


The present invention provides a recombinant turkey herpesvirus modified by the presence of the cdna encoding the hemagglutinin protein of avian influenza virus under a promoter. A poultry vaccine comprising the recombinant turkey herpesvirus described in the present invention can induce serological responses that may be easily detected by the hemagglutination inhibition assay but not by commercially available diagnostic elisa kits; thus enabling easy differentiation between vaccination and field infection..
Zeon Corporation
04/23/15
20150110785

Methods of impairing osteoclast differentiation using antibodies that bind siglec-15


This invention relates, in part, to unique and newly identified genetic polynucleotides involved in the process of bone remodeling, variants and derivatives of the polynucleotides and corresponding polypeptides, uses of the polynucleotides, polypeptides, variants and derivatives, and methods and compositions for the amelioration of symptoms caused by bone remodeling disorders. Disclosed in particular are the isolation and identification of polynucleotides, polypeptides, variants and derivatives involved in osteoclast activity, validation of the identified polynucleotides for their potential as therapeutic targets and use of the polynucleotides, polypeptides, variants and derivatives for the amelioration of disease states and research purposes..
Alethia Biotherapeutics Inc.
04/23/15
20150110774

S100 protein inhibitors for treating leukemia


The present invention relates to a compound, composition and method for reducing or inhibiting the differentiation or development of progenitor blood cells into malignant cells, leukemia cells or physiologically pathological cells. Particularly, the invention describes the use of inhibitors of s100 proteins, including myeloid related proteins.
Universite Laval
04/23/15
20150110393

Method of detecting transition area and processing image using the same


Provided are a method of detecting a transition area and an apparatus for processing an image using the same. The apparatus includes a line representative value calculator configured to calculate line representative values of an image including a non-image display area, an image display area, and a transition area interposed between the non-image display area and the image display area, and a transition area detector configured to calculate first-order and second-order differentiations of the line representative values, calculate a threshold value of the transition area using first-order and second-order-differentiation-representative-values of a first line group including a plurality of lines in a window including a plurality of lines and first-order and second-order-differentiation-representative-values of a second line group including a plurality of lines, and detect the transition area..
Anapass Inc.
04/16/15
20150105299

Method for differentiation of polynucleotide strands


Objective of the present invention is to provide a method for keeping of directional information in double-stranded dna. We suggest to convert polynucleotide into a hybrid double-stranded dna.
Max-planck-gesellschaft Zur Forderung Der Wissenschaften E.v.
04/16/15
20150104879

Composition for diagnosing liver cancer and methods of diagnosing liver cancer and obtaining information for diagnosing liver cancer


Provided is method of diagnosing liver cancer in a subject, the method comprising contacting a sample from a subject with a substance that specifically binds to transmembrane emp24 domain trafficking protein 2 (tmed2), cluster of differentiation 43 (cd43), or any combination thereof on the surface of a microvesicle; and measuring the level of the substance bound to microvesicles in the sample; and related methods and compositions.. .
Samsung Electronics Co., Ltd.
04/16/15
20150104870

Neuronal differentiation promoter


The present invention provides an agent for promoting neuronal differentiation of neural stem cells, which contains a p38 inhibitor. In addition, the present invention provides a method of promoting neuronal differentiation of neural stem cells, which includes cultivating neural stem cells in the presence of a p38 inhibitor.
Keio University
04/16/15
20150104431

Cardiac muscle repair or regeneration using bone marrow-derived stem cells


Disclosed are compositions and methods for repairing and/or regenerating cardiac tissue by administering adult bone marrow-derived stem cells to an individual. These cells can be administered as a liquid injectible or as a preparation of cells in a matrix which is or becomes solid or semi-solid.
Mesoblast International Sarl
04/16/15
20150104430

Methods and compositions for generating pancreatic progenitors and functional beta cells from hpscs


Methods and compositions for producing nkx6-1+ pancreatic progenitor cells and/or insulin producing cells from an endodermal cell population, the method comprising contacting the endodermal cell population with an egf component, a nicotinamide component and/or a noggin component, optionally a combination of at least one egf component and at least one nicotinamide component to induce the differentiation of at least one endodermal cell into a nkx6-1+ pancreatic progenitor cell, the combination optionally further comprising at least one noggin component.. .
University Health Network
04/16/15
20150104429

Synthetic triterpenoids and methods for modulating stem/progenitor cell gene expression


Synthetic triterpenoids and methods of using the same to induce gene expression and differentiation of stem or progenitor cells are provided. Furthermore, the present invention provides methods for producing a cell, such as a stem or progenitor cell, with induced gene expression by contacting a stem or progenitor cell with an effective amount of a synthetic triterpenoid to induce the expression of one or more of sox9 (sex determining region y-box 9), col2a1 (type ii collagen (alpha1)), tgf-βi, tgf-p2, tgf-33, bmp2, bmp4, bmprii (bone morphogenic protein receptor ii), smad (small mothers against decapentaplegic) 3, smad4, smad6, smad7, timp (tissue inhibitor of metalloproteinase)-1 or timp-2 in the stem or progenitor cell, wherein the stem or progenitor cell is not a mesenchymal stem cell, periosteium cell or osteoprogenitor cell.
Trustees Of Dartmouth College
04/09/15
20150101009

Method for providing access of an user end device to a service provided by an application function within a network structure and a network structure


For allowing a simple and reliable differentiation of ues behind a gw from an af side a method for providing access of an user end device (ue) to a service provided by an application function (af) within a network structure is claimed, wherein the ue is authenticated by a gateway (gw) to which the ue is attached and which provides access to the af via a broadband access network (bb access network). The method is characterized in that the gw informs a state database (sdb) on service flow requests to or from the authenticated ue towards the af, that the gw additionally sends nat (network address translation) or napt (network address and port translation) binding information of a respective nat or napt binding created by the gw regarding the authenticated ue and a respective service flow request to the sdb and that the sdb sends the nat or napt binding information or an ue identifier to the af, so that the af—after having received the service flow request from the gw—can correlate the authenticated ue with the service flow request.
Nec Europe Ltd.
04/09/15
20150099964

System and differentiation of normal myocardium from diffuse disease using t1 mapping in non-ischemic cardiomyopathies and others


A method for differentiation of normal myocardium from diffuse disease using t mapping includes acquiring one or more images of a patient by an imaging apparatus, generating a t1 map from the one or more images, defining a region of interest within the one or more images, determining the average t1 value within the region of interest, comparing the average t1 value within the region of interest to a cut-off t1 value, and determining a diagnosis of the region of interest from the comparison.. .
Koninklijke Philps N.v.
04/09/15
20150099666

Method and device for combined detection of viral and bacterial infections


A lateral flow assay detects and differentiates between viral and bacterial infections. A combined point of care diagnostic device tests markers for viral infection and markers for bacterial infection, to effectively assist in the rapid differentiation of viral and bacterial infections.
Rapid Pathogen Screening, Inc.
04/09/15
20150099300

Use of adipose tissue-derived stromal cells for chondrocyte differentiation and cartilage repair


Methods and compositions for directing adipose-derived stromal cells cultivated in vitro to differentiate into cells of the chondrocyte lineage are disclosed. The invention further provides a variety of chondroinductive agents which can be used singly or in combination with other nutrient components to induce chondrogenesis in adipose-derived stromal cells either in cultivating monolayers or in a biocompatible lattice or matrix in a three-dimensional configuration.
Artecel Sciences Inc.
04/09/15
20150099296

Promoter-regulated differentiation-dependent self-deleting cassette


Targeting constructs and methods of using them are provided for differentiation-dependent modification of nucleic acid sequences in cells and in non-human animals. Targeting constructs comprising a promoter operably linked to a recombinase are provided, wherein the promoter drives transcription of the recombinase in an differentiated cell but not an undifferentiated cell.
Regeneron Pharmaceuticals, Inc.
04/02/15
20150094277

Combination therapy and methods for treatment and prevention of hyperproliferative diseases


The present invention provides therapy and methods for the treatment and prevention of diseases of cell proliferation such as cancer, benign tumors, and viral diseases such as hiv-aids, hepatitis b, hepatitis c and cirrhosis. The methods of this invention consist of the administration to a patient of a combination of effective amounts of agents capable of eradicating the neoplastic cells, while sparing the non-neoplastic cells from cytotoxic side-effects.
04/02/15
20150093828

Cell culturing article and manufacturing thereof


The disclosure provides a cell culturing article. The cell culturing article includes a substrate having a surface, a hydrophilic copolymer layer positioned on the surface of the substrate, and a plurality of peptide chains individually conjugated to a surface of the hydrophilic copolymer layer.
National Central University
04/02/15
20150093363

Osteogenic differentiation of mesenchymal stem cells


The present invention relates to a method for inducing and/or promoting osteogenic differentiation using extracellular vesicles and the use thereof.. .
Biomatcell Ab
04/02/15
20150092916

Material differentiation with phase contrast imaging


A method and system to determine material composition of an object comprises capturing a series of digital radiographic images of the object using a single exposure energy level. An intensity of the captured images is determined as well as phase shift differences.
Carestream Health, Inc.
03/26/15
20150087790

Polycarbonate containing compounds and methods related thereto


Disclosed herein are crosslinked polycarbonates, composition thereof and methods thereof. The cross-linked polycarbonates can be prepared from allyl or epoxy polycarbonates.
Vanderbilt University
03/26/15
20150087062

System and electrospun biodegradable scaffold for bone repair


This invention relates a structure and system for growth factor incorporation which can improve the osteogenic differentiation of hmscs, for potential bone regeneration and bone growth applications or used alone for bone repair or growth applications. The system comprises a biodegradable polyester, a hydrophilic polymer, a growth factor and optionally a bioceramic..
03/26/15
20150087060

Method for inducing erythropoietin-producing cell


An object of the present invention is to provide a method for inducing the differentiation of erythropoietin-producing cells from human pluripotent stem cells. The above object is achieved by providing a method for inducing the differentiation of erythropoietin-producing cells from human pluripotent stem cells using a medium containing a specific growth factor and a specific compound..
Kyoto University
03/26/15
20150086989

Methods and nucleic acids for analyses of cellular proliferative disorders


Aspects of the invention provide methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among liver cell proliferative disorders or for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. Particular aspects disclose and provide genomic sequences the methylation patterns of which have substantial utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients..
Epigenomics Ag
03/26/15
20150086636

Myostatin inhibition for enhancing muscle and/or improving muscle function


The present invention relates to methods for inhibiting myostatin, a regulator of muscle mass, for muscle enhancement (including inducing hypertrophy and/or hyperplasia) as well as improving muscle function (including decreasing atrophy and/or increasing endurance, force and/or strength). Some of the methods involve delivering genes to cells using gene delivery or other delivery techniques known in the art in order to inhibit myostatin.
Nationwide Children's Hospital
03/26/15
20150086511

Survival, differentiation and structural integration of human neural stem cells grafted into the adult rat spinal cord


The present invention provides methods and compositions for treating spinal cord diseases and injuires. The methods involve transplanting neural stem cells which have been previously expanded in vitro into a patient such that the cells can ameliorate the disease or injury.
The Johns Hopkins University
03/26/15
20150086508

Compositions and methods for enhancing epidermal repair and cutaneous innate immunity


The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair.
03/19/15
20150081018

Methods and substrates for differentiation of neural stem cells


The present invention is directed to methods and substrates for promoting the differentiation of neural stem cells to neurons.. .
Rutgers, The State University Of New Jersey
03/19/15
20150080770

Differentiation of stem cells with nanoparticles


This invention relates to stimulation of stem cells and other progenitors of differentiated cells using nanoparticles and electromagnetic stimulation. The invention provides a method for differentiating mesenchymal stem cells (mscs) towards osteoblasts and other connective tissue.
The Research Foundation For The State University Of New York
03/19/15
20150079153

Cell suspension and use thereof


The present invention provides for methods and devices suitable for producing a transplantable cellular suspension of living tissue suitable for promoting tissue regeneration in an epithelium-related procedure, as well as compositions produced therefrom. The cellular suspension can include viable and functioning cells at various stages of differentiation, including undifferentiated/progenitor cells and differentiated cells, as well as those in between.
Avita Medical Ltd.
03/19/15
20150079143

Three-dimensional scaffolds for tissue engineering made by processing complex extracts of natural extracellular matrices


Methods of making a biologically active three-dimensional scaffold capable of supporting growth and differentiation of a cell are described. Biologically active three-dimensional scaffold made by the methods of the invention and an engineered tissue made from the scaffolds are described.
Drexel University
03/19/15
20150077383

Multiple bridges single sided touch sensor


A touch sensor panel can include a plurality of drive lines crossing a plurality of sense lines, forming an array. The plurality of drives lines and the plurality of sense lines can be formed by interconnecting sections of at least one conductive material with a plurality of bridges.
Apple Inc.


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Differentiation topics: Differentiation, Stem Cells, Antibodies, Proliferation, Transplant, Smooth Muscle, Heterogeneous, Mesodermal, Cell Differentiation, Metabolism, Nucleic Acids, Therapeutics, Oligodendrocyte, Antagonist, Dysfunction

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