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Dextran

Dextran-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Stable, spray dryed, immunogenic, viral compositions
Aeras
January 18, 2018 - N°20180015158

Viruses, and particularly genetically engineered, replication deficient viruses such as adenoviruses, poxviruses, mva viruses, and baculoviruses which encode one or more antigens of interest, such as tb, malarial, and hiv antigens, are spray dried with a mannitol-cyclodextrin-trehalose-dextran (mctd) to form a powder where the viability of the viruses are maintained at a suitable level for mass vaccinations after spray drying, ...
Methods for liquid chromatography calibration for rapid labeled n-glycans
Waters Technologies Corporation
November 23, 2017 - N°20170336368

Methods are provided for making rapid labeled dextran ladders and other calibrants useful in liquid chromatography. The methodologies include a two-step process comprising a reductive amination step of providing a reducing glycan and reacting it with a compound having a primary amine to produce an intermediate compound. The intermediate compound is then rapidly tagged with a rapid tagging reagent to ...
Polypeptides having dextranase activity and polynucleotides encoding same
Novozymes A/s
October 26, 2017 - N°20170306427

The present invention relates to isolated polypeptides having dextranase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
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Method of forming inorganic nanocages
Research Foundation Of The City University Of New York
October 05, 2017 - N°20170282252

Nanocages are formed by etching nancubes. The nanocubes are added to an aqueous system having an amphiphilic lipid dissolved in an organic solvent (e. G. A hydrophobic alcohol) to form reverse micelles. As the water evaporates the micelles shrink as etching of the flat surface of the nanocubes occurs. In this fashion hollow nanocages are produced. In one embodiment, the ...
Materials and methods for preventing and treating microbe-mediated epithelial disorders
The University Of Chicago
October 05, 2017 - N°20170281668

The present invention provides pharmaceutical compositions in the form of relatively high molecular weight biocompatible polymers such as polyethylene glycol, optionally supplemented with a protective polymer such as dextran and/or essential pathogen nutrients such as l-glutamine. Also provided are methods for preventing or treating gut-derived sepsis attributable to intestinal pathogens such as pseudomonas aeruginosa by administering high molecular weight ...
Process for the production of isomaltooligosaccharides
Isothrive Llc
September 28, 2017 - N°20170275661

The present invention provides a method for the production of oligosaccharides by the fermentation of dextran-sucrase-producing microorganisms with sucrose and maltose. The disclosed process allows for the control of the final composition of the isomaltooligosaccharides by adjustments to ph and the initial ratio of sucrose to maltose.
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Low sweel tissue adhesive and sealant formulations
Actamax Surgical Materials, Llc
September 28, 2017 - N°20170274117

A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized dextran containing pendant aldehyde groups with a multi-arm polyethylene glycol amine is described. The hydrogel exhibits little to no swell upon exposure to physiological conditions. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a low swell hydro gel to inhibit complications, such as ...
Low sweel tissue adhesive and sealant formulations
Actamax Surgical Materials, Llc
September 28, 2017 - N°20170274116

A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized dextran containing pendant aldehyde groups with a multi-arm polyethylene glycol amine is described. The hydrogel exhibits little to no swell upon exposure to physiological conditions. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a low swell hydrogel to inhibit complications, such as fibrosis, ...
In-situ cross-linkable polymeric compositions and methods thereof
Cresilon, Inc.
September 21, 2017 - N°20170266339

A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or deae-dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying ...
Injectable neurosteroid formulations containing nanoparticles
September 14, 2017 - N°20170258812

Where the variables r1-r9 and x are defined herein and at least one surface stabilizer. The surface stabilizer can be a polymeric surface stabilizer such as hydroxyethyl starch, dextran, or povidone. The injectable neurosteroid nanoparticle formulation can be an intravenous formulation. The disclosure also provides a lyophilized powder of the injectable neurosteroid nanoparticle formulation that can be reconstituted in ...
Protein with dextran-saccharase activity, and uses
Universite Paul Sabatier Toulouse Iii
August 31, 2017 - N°20170247669

The invention relates to: a protein having dextran-saccharase activity and the sequence seq id no: 1 for an no acid sequence; a protein having dextran-saccharase activity and the sequence seq id no: 2 for an amino acid sequence; a complex containing a substrate and a protein with dextran-saccharase activity a method for synthesizing dextrans; and dextrans. The invention also relates to a ...
Stabilized glycosaminoglycan preparations and related methods
S.k. Pharmaceuticals, Inc.
August 24, 2017 - N°20170239287

Compositions comprising a glycosaminoglycan (e. G., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e. G., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e. G., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, ...
Cross-linked polymer mixture of hyaluronic acid and dextran grafted with cyclodextrins and uses thereof
Galderma S.a.
July 27, 2017 - N°20170210829

A hydrogel product including a cross-linked polymer mixture of dextran cross-linked to hyaluronic acid, and one or more cyclodextrin molecules. The one or more cyclodextrin molecules are grafted onto the cross-linked polymer mixture, e. G. By amide bonds. The dextran may be cross-linked to the hyaluronic acid by ether bonds. The one or more cyclodextrin molecules may be grafted onto ...
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Payload-polymer-protein conjugates
Glykos Finland Oy
July 06, 2017 - N°20170189549

The present invention relates to a conjugate represented by the formula [d-l-y—(ch2)n-o]m—p-t wherein t is a protein; p is a polymer selected from the group consisting of dextran, mannan, pullulan, hyaluronic acid, hydroxyethyl starch, chondroitin sulphate, heparin, heparin sulphate, polyalkylene glycol, ficoll, polyvinyl alcohol, amylose, amylopectin, chitosan, cyclodextrin, pectin and carrageenan, or a derivative ...
Compositions and methods for the removal of sulfates and metals from waste water
Hppe, Llc
June 15, 2017 - N°20170166462

The invention is directed to compounds, compositions and methods for the removal of contaminants from fluids and, in particular sulfates and/or metals from industrial waste water. Compounds and compositions of the invention contain polysaccharides and other organic molecules. These flocculating agents are safe and effective, requiring no special handling procedures. Flocculation compounds include biopolymers of dextran, modified dextran and ...
Membrane for blood purification
Gambro Lundia Ab
June 15, 2017 - N°20170165616

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e. G. By hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (mwro) of between 9. 0 kd and 14. 5 kd and a molecular weight cut-off (mwco) of between 55 kd and 130 kd ...
Recovery of mining processing product using boronic acid-containing polymers
Ecolab Usa Inc.
June 08, 2017 - N°20170158522

Methods and compositions for improving performance of flocculants in an industrial production process. Methods include ph triggered cross-linking reaction between a flocculating agent, such as dextran, and a composition comprising a boronic acid-containing polymer. The ph trigger can be provided by a fluid having a ph of 8 or more. The production process can be a bayer process and the fluid ...
In-situ cross-linkable polymeric compositions and methods thereof
Cresilon, Inc.
June 08, 2017 - N°20170157286

A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or deae-dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying ...
Erythrocyte aggregation and leukocyte isolation
General Electric Company
June 01, 2017 - N°20170153223

A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation ...
Prebiotic composition or pharmaceutical composition synthesized from catalytic domains producing highly alpha-1,2 branched dextran
Institut National Des Sciences Appliquees (insa)
June 01, 2017 - N°20170152489

The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with . Alpha.(1. Fwdarw. 2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same.
The use of dextran sulfate having an average molecular weight below 10000 da for inducing angiogenesis ...
Tx Medic Ab
June 01, 2017 - N°20170151275

The present embodiments relate to the use of dextran sulfate having an average molecular weight below 10 000 da for inducing angiogenesis in a subject and for increasing blood flow in a subject suffering from ischemia.
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