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Dextran

Dextran-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Polypeptides having dextranase activity and polynucleotides encoding same
Novozymes A/s
October 26, 2017 - N°20170306427

The present invention relates to isolated polypeptides having dextranase activity, and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
Peptides for diagnosis and treatment of cancer
National Taiwan University
October 05, 2017 - N°20170283468

The present invention provides a method of peptide histochemical diagnosis to detect the peptide binding protein in the cancer tissue. This peptide binding specifically to tumor cells is linked to the dextran coated iron oxide nanoparticle. The peptide linked dextran coated iron oxide nanoparticle can be used to bind to the formalin-fixed and paraffin-embedded tumor surgical specimens, and the method ...
Method of forming inorganic nanocages
Research Foundation Of The City University Of New York
October 05, 2017 - N°20170282252

Nanocages are formed by etching nancubes. The nanocubes are added to an aqueous system having an amphiphilic lipid dissolved in an organic solvent (e. G. A hydrophobic alcohol) to form reverse micelles. As the water evaporates the micelles shrink as etching of the flat surface of the nanocubes occurs. In this fashion hollow nanocages are produced. In one embodiment, the ...
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Process for the production of isomaltooligosaccharides
Isothrive Llc
September 28, 2017 - N°20170275661

The present invention provides a method for the production of oligosaccharides by the fermentation of dextran-sucrase-producing microorganisms with sucrose and maltose. The disclosed process allows for the control of the final composition of the isomaltooligosaccharides by adjustments to ph and the initial ratio of sucrose to maltose.
Method for purification of monoclonal antibodies
Laboratoire Francais Du Fractionnement Et Des Biotechnologies
September 28, 2017 - N°20170274299

Disclosed is a method for purification of monoclonal antibodies or of a fusion protein between the fc segment of an antibody and a second polypeptide, including a) an affinity chromatography step on a resin having as a matrix a crosslinked methacrylate polymer gel, on which the protein a is grafted, b) a viral inactivation step, c) a chromatography step exchanging ...
Low sweel tissue adhesive and sealant formulations
Actamax Surgical Materials, Llc
September 28, 2017 - N°20170274117

A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized dextran containing pendant aldehyde groups with a multi-arm polyethylene glycol amine is described. The hydrogel exhibits little to no swell upon exposure to physiological conditions. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a low swell hydro gel to inhibit complications, such as ...
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In-situ cross-linkable polymeric compositions and methods thereof
Cresilon, Inc.
September 21, 2017 - N°20170266339

A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or deae-dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying ...
Injectable neurosteroid formulations containing nanoparticles
Cresilon, Inc.
September 14, 2017 - N°20170258812

Where the variables r1-r9 and x are defined herein and at least one surface stabilizer. The surface stabilizer can be a polymeric surface stabilizer such as hydroxyethyl starch, dextran, or povidone. The injectable neurosteroid nanoparticle formulation can be an intravenous formulation. The disclosure also provides a lyophilized powder of the injectable neurosteroid nanoparticle formulation that can be reconstituted in ...
Protein with dextran-saccharase activity, and uses
Universite Paul Sabatier Toulouse Iii
August 31, 2017 - N°20170247669

The invention relates to: a protein having dextran-saccharase activity and the sequence seq id no: 1 for an no acid sequence; a protein having dextran-saccharase activity and the sequence seq id no: 2 for an amino acid sequence; a complex containing a substrate and a protein with dextran-saccharase activity a method for synthesizing dextrans; and dextrans. The invention also relates to a ...
Stabilized glycosaminoglycan preparations and related methods
S.k. Pharmaceuticals, Inc.
August 24, 2017 - N°20170239287

Compositions comprising a glycosaminoglycan (e. G., a hyaluronan, hyaluronic acid, hyaluronate, sodium hyaluronate, dermatan sulfate, karatan sulfate, chondroitin 6-sulfate, heparin, etc.) in combination with at least one component selected from; i) polyglycols (e. G., polyethylene glycol), ii) long chain hydroxy polyanionic polysaccharides (e. G., dextran, sodium alginate, alginic acid, propylene glycol alginate, carboxymethyl cellulose and carboxyethyl cellulose, hydroxyl ethyl starch, ...
Cross-linked polymer mixture of hyaluronic acid and dextran grafted with cyclodextrins and uses thereof
Galderma S.a.
July 27, 2017 - N°20170210829

A hydrogel product including a cross-linked polymer mixture of dextran cross-linked to hyaluronic acid, and one or more cyclodextrin molecules. The one or more cyclodextrin molecules are grafted onto the cross-linked polymer mixture, e. G. By amide bonds. The dextran may be cross-linked to the hyaluronic acid by ether bonds. The one or more cyclodextrin molecules may be grafted onto ...
Cyclodextrin-grafted hyaluronic acid crosslinked with dextran and uses thereof
Galderma S.a.
July 13, 2017 - N°20170196991

A hydrogel product including one or more cyclodextrin molecules grafted to hyaluronic acid and dextran, wherein the cyclodextrin-grafted hyaluronic acid is cross-linked to the dextran. The one or more cyclodextrin molecules are grafted, e. G. By amide bonds, to the hyaluronic acid prior to the cross-linking with dextran. The cyclodextrin-grafted hyaluronic acid may be cross-linked to the dextran by ether ...
Payload-polymer-protein conjugates
Glykos Finland Oy
July 06, 2017 - N°20170189549

The present invention relates to a conjugate represented by the formula [d-l-y—(ch2)n-o]m—p-t wherein t is a protein; p is a polymer selected from the group consisting of dextran, mannan, pullulan, hyaluronic acid, hydroxyethyl starch, chondroitin sulphate, heparin, heparin sulphate, polyalkylene glycol, ficoll, polyvinyl alcohol, amylose, amylopectin, chitosan, cyclodextrin, pectin and carrageenan, or a derivative ...
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Membrane for blood purification
Gambro Lundia Ab
June 15, 2017 - N°20170165616

The present disclosure relates to semipermeable membranes which are suitable for blood purification, e. G. By hemodialysis, which have an increased ability to remove larger molecules while at the same time effectively retaining albumin. The membranes are characterized by a molecular retention onset (mwro) of between 9. 0 kd and 14. 5 kd and a molecular weight cut-off (mwco) of between 55 kd and 130 kd ...
Recovery of mining processing product using boronic acid-containing polymers
Ecolab Usa Inc.
June 08, 2017 - N°20170158522

Methods and compositions for improving performance of flocculants in an industrial production process. Methods include ph triggered cross-linking reaction between a flocculating agent, such as dextran, and a composition comprising a boronic acid-containing polymer. The ph trigger can be provided by a fluid having a ph of 8 or more. The production process can be a bayer process and the fluid ...
In-situ cross-linkable polymeric compositions and methods thereof
Cresilon, Inc.
June 08, 2017 - N°20170157286

A biocompatible polymeric composition for cross-linking in-situ in a wound is disclosed comprising 1) one or more polyanionic polymers such as alginates or hyaluronates, able to be cross-linked the surface of the wound and 2) one or more polycationic polymers such as chitosan or deae-dextran, that assists in the solidification process as well as speeds up hemostasis without the need for applying ...
Erythrocyte aggregation and leukocyte isolation
General Electric Company
June 01, 2017 - N°20170153223

A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation ...
Prebiotic composition or pharmaceutical composition synthesized from catalytic domains producing highly alpha-1,2 branched dextran
Institut National Des Sciences Appliquees (insa)
June 01, 2017 - N°20170152489

The invention relates to an isolated polypeptide with an glycosyl transferase enzymatic activity for producing dextrans with . Alpha.(1. Fwdarw. 2) sidechains, comprising at least one region for bonding to glucan and a catalytically active region situated beyond the region bonding to glucan. The invention further relates to polynucleotides coding for said enzymes and vectors containing the same.
The use of dextran sulfate having an average molecular weight below 10000 da for inducing angiogenesis ...
Tx Medic Ab
June 01, 2017 - N°20170151275

The present embodiments relate to the use of dextran sulfate having an average molecular weight below 10 000 da for inducing angiogenesis in a subject and for increasing blood flow in a subject suffering from ischemia.
Very high molar mass dextrans
Tx Medic Ab
May 25, 2017 - N°20170145120

The subject matter of the invention is dextrans which have between 95% and 99% of α-1,6 glucosidic bonds, a weight-average molar mass mw at least equal to 0. 7×109 g. Mol−1, and a dispersity index d of between 1. 3 and 3. The invention also relates to a dextran saccharase which makes it possible to produce such dextrans, and to a method for ...
Multi-layered anti-adhesion device
Tx Medic Ab
May 25, 2017 - N°20170143874

Compositions and methods are provided for preparing an adhesion barrier in the form of a foldable or flexible biodegradable polymer matrix that effectively reduces, prevents or treats adhesions in a patient in need thereof. In one embodiment, the matrix comprises a first porous layer comprising collagen and a second porous layer comprising collagen and dextran, wherein the dextran is loaded ...
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