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Cytokine patents



      
           
This page is updated frequently with new Cytokine-related patent applications. Subscribe to the Cytokine RSS feed to automatically get the update: related Cytokine RSS feeds. RSS updates for this page: Cytokine RSS RSS


Date/App# patent app List of recent Cytokine-related patents
07/17/14
20140199322
 Transdiscal administration of specific inhibitors of pro-inflammatory cytokines patent thumbnailTransdiscal administration of specific inhibitors of pro-inflammatory cytokines
The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.. .
07/10/14
20140194628
 Substituted imidazo ring systems and methods patent thumbnailSubstituted imidazo ring systems and methods
Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.. .
07/10/14
20140193529
 Modulation of thymosin beta-4 in skin patent thumbnailModulation of thymosin beta-4 in skin
Methods for preventing, ameliorating, or reducing dermatological signs of inflammation are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin and inhibit production of pro-inflammatory chemokines and/or cytokines. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin..
07/10/14
20140193411
 Multimeric constructs patent thumbnailMultimeric constructs
Multimeric fusion proteins of an ig-like domain of flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascularization in individuals with pathological conditions related to neovascularization.
07/10/14
20140193361
 Systemic glucose tolerance in type-2 diabetes patent thumbnailSystemic glucose tolerance in type-2 diabetes
Obesity is associated with a state of chronic low-grade inflammation and the present invention establishes that adipose-resident natural killer t (nkt) cells attenuate inflammation in adipose tissue and improves systemic glucose homeostasis in mice at different stages of obesity. Accordingly, the present invention provides methods of treating type-2 diabetes or those at risk for type-2 diabetes using activators of adipose-resident nkt cells.
07/03/14
20140187845
 Radio-immuno-modulation treatment for advanced cancer and monitoring tolerance and cellular immune response at the tumor site patent thumbnailRadio-immuno-modulation treatment for advanced cancer and monitoring tolerance and cellular immune response at the tumor site
A combination therapy for treating advanced cancer, comprises, first, performing targeted low dose radiation therapy on a recipient tumoral site to generate an inflammation zone and an immuno-stimulant effect, including release of cytokines and chemokines. Secondly, hematopoietic cells from a suitable donor are administered intravenously in order to initiate an allogeneic reaction.
07/03/14
20140186319
 Notch induced natural killer cell generation and therapeutic uses patent thumbnailNotch induced natural killer cell generation and therapeutic uses
A method of preparing differentiated nk cells by ex vivo expansion includes the steps of; (1) isolating a plurality of cd34+ hematopoietic cells; (2) culturing the cells in a medium, wherein the medium includes an effective amount of a notch ligand and one or more cytokines selected from the group consisting of il-7, il-15, scf, flt-3, il-3 and il-6; and (3) maintaining the cells in culture for a duration of time sufficient to produce nk cells.. .
06/26/14
20140178987
 Stem cell culture medium and its applications as well as a stem cell culture method patent thumbnailStem cell culture medium and its applications as well as a stem cell culture method
The present invention discloses a stem cell culture medium and its applications as well as a stem cell culture method. The said stem cell culture medium contains no serum.
06/26/14
20140178367
 Methods of treating inflammatory diseases by targeting the chemoattractant cytokine receptor 2 (ccr2) or chemokine (c-c motif) ligand 2 (ccl2) patent thumbnailMethods of treating inflammatory diseases by targeting the chemoattractant cytokine receptor 2 (ccr2) or chemokine (c-c motif) ligand 2 (ccl2)
Methods of treating inflammatory diseases, e.g., diseases associated with inflammatory cd14+/cd16− monocytes, e.g., amyotrophic lateral sclerosis (als), stroke, and glaucoma, using compounds such as small molecules and antibodies that target ccr2 or ccl2.. .
06/19/14
20140172054
 Methods and apparatus for bilateral renal neuromodulation patent thumbnailMethods and apparatus for bilateral renal neuromodulation
Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
06/19/14
20140170658
Mammalian cytokines; related reagents
Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided..
06/19/14
20140170171
Targeted cytokine for treatment of musculoskeletal diseases
Provided are proteins and polynucleotides, complexes and compositions containing the proteins, and methods for their use in administration to subjects and for disease treatment. Among the provided proteins and complexes are complexes containing a tgf-beta associated with immunoglobulins (such as iggs) or functional portions thereof including fc portions, such as by non-covalent bonds.
06/19/14
20140170120
Cytokine induction of selectin ligands on cells
Methods and compositions for treating cells with cytokines are provided herein.. .
06/19/14
20140170109
Il-12 immunoconjugate
Conjugate comprising interleukin-12 (il-12) and a single chain targeting portion comprising two antigen binding sites. The targeting portion may comprise an antibody fragment such as a single chain diabody.
06/12/14
20140163204
Derivatives of growth hormone and related proteins
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins.
06/12/14
20140161766
Tetrameric cytokines with improved biological activity
The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-mab dnl complex comprises an igg antibody attached to two ad (anchor domain) moieties and four cytokines, each attached to a ddd (docking and dimerization domain) moiety.
06/05/14
20140154220
Methods and compositions for improved tissue regeneration by suppression of interferon-gamma and tumor necrosis factor-alpha
The present invention discloses methods, compositions and devices for improving tissue regeneration by suppressing the effects of several proinflammatory cytokines such as tnf-α and ifn-γ. Compositions and devices of this invention will generally include one or more anti-inflammatory agent(s) capable of reducing the level of tnf-α, ifn-γ, or both.
06/05/14
20140154215
Herpes virus strains
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional icp34.5 gene and a functional icp47 encoding gene.. .
06/05/14
20140154207
Kit containing stem cells and cytokines for use in attenuating immune responses
The present invention relates to a composition and methods of treatment for inflammation comprising of adult stem cells and inflammatory cytokines. The invention further relates to the treatment of inflammation associated with autoimmune disorders, allergies, sepsis, cancer as well as to preventing, reducing or treating transplant rejection and/or graft-versus-host disease (gvhd)..
05/29/14
20140148394
Compositions and methods for modulating gamma-c-cytokine activity
The various embodiments relate to peptide antagonists of γc-family cytokines, interleukin-2 (il-2), interleukin-4 (il-4), interleukin-7 (il-7), interleukin-9 (il-9), interleukin-15 (il-15), and interleukin-21 (il-21). The γc-cytokines are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd).
05/29/14
20140147414
Compositions and methods for treatment of intracellular damage
Pre-implantation factor (pif) may be used to treat intracellular damage. Aspects of the invention are directed to a method of treating intracellular damage comprising administering pif to a subject in need thereof.
05/22/14
20140142042
Skin wound healing and scar reduction with prostaglandin ep4 agonist combinations
A combination of a prostaglandin ep4 agonist and an effective amount of: a prostaglandin ep2 agonist, a skin growth factor, a small peptide, a small inhibitory rna targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine a2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.. .
05/22/14
20140141513
Cell line of lymphocytes comprising gamma-delta t cells, composition and production method thereof
The present invention shows that human vδ1+ ncr+ t cells can be differentiated and expanded from total γδ peripheral blood lymphocytes (pbls), upon regular in vitro or ex vivo stimulation with γδtcr agonists and γc-family cytokines. This subset surprisingly expresses nkp30, nkp44 and nkp46, and high levels of granzyme b that associate with highly enhanced cytotoxicity against lymphoid leukemias..
05/22/14
20140141485
Zcytor17 heterodimeric cytokine receptor
Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto..
05/22/14
20140140967
Pluripotent stem cell-derived brown adipocytes, pluripotent stem cell-derived cell aggregate, method for producing same, and cell therapy and medical therapy therefor
Provided are a method of producing brown adipocytes from pluripotent stem cells, a method of producing cell aggregates as an intermediate product thereof, pluripotent stem cell-derived cell aggregates and pluripotent stem cell-derived brown adipocytes produced by these methods, and cell therapy using the pluripotent stem cell-derived brown adipocytes. In the method of producing brown adipocytes from pluripotent stem cells, cell aggregates are produced from pluripotent stem cells by a method including the step (a), and brown adipocytes are prepared from the cell aggregates by a method including the step (b).
05/22/14
20140140954
Methods of modulating cytokine activity; related reagents
Provided are methods of modulating cytokine activity, e.g., for the purpose of treating immune and inflammatory disorders, including tumors and cancer. Also provided are methods of administering agonists or antagonists of il-33 and il-33 receptor..
05/08/14
20140128276
Cytokine profiles as methods for diagnosis and prognosis of irritable bowel syndrome
Methods, devices, and kits for diagnosing or evaluating irritable bowel syndrome employ an analysis for the presence and amount of specific cytokines. The levels of such cytokines provide an index for diagnosis and/or evaluation of therapeutic response.
05/08/14
20140127268
Method for expanding monocytes
The invention relates to an ex vivo method for expanding monocytes, macrophages or dendritic cells, which method comprises inhibiting the expression or the activity of mafb and c-maf in monocytes, macrophages or dendritic cells; and expanding the cells in the presence of at least one cytokine or an agonist of cytokine receptor signalling.. .
05/01/14
20140121277
Use of methionine sulfoximine to treat acute liver failure and other diseases caused by an inflammatory cytokine response
Methods for treating or preventing an inflammatory response comprising administering an enantiomer or racemic mixture of methionine sulfoximine (mso). The mso may be l-methionine s-sulfoximine (lsmso), l-methionine r-sulfoximine (lrmso), or racemic mixture of lsmso and lrmso.
05/01/14
20140121156
Nutritional approach to the control of anemia, diabetes and other diseases or conditions and prevention of associated comorbid states with the use of ergothioneine
Nutritional products, compositions, pharmaceutical preparations and methods of use are disclosed for the prevention, suppression and treatment of anemia and/or diabetes and its various associated comorbidities. Uses of ergothioneine to neutralize free radicals and/or cytokines, reduce oxidative stress, prevent inflammation, stimulate red blood cell production with increased levels of hemoglobin, and/or stabilize iron in its normal 2+ charge for proper oxygen binding and carrying are further disclosed.
05/01/14
20140120110
Angiogenic and immunologic applications of anti-cd160 specific compounds obtainable from mab cl1-r2
The present invention relates to biological and medical applications of an anti-cd160 monoclonal antibody (cl1-r2 cncm i-3204) and of the conservative equivalents thereof. It more particularly relates to the applications of these anti-cd160 compounds in the fields of ec angiogenesis, and nk and t cytokine production..
04/24/14
20140113962
Inhibitors of nitric oxide synthase
The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (inos) and the production of no. Methods of inhibiting the induction of proinflammatory cytokines are also described.
04/24/14
20140113867
Apls for treating arthritis
One embodiment of a therapeutic composition comprises one or more apls, e.g., apl a12, for treating diseases or disorders related to arthritis, including rheumatoid arthritis. Another embodiment includes a method of inducing a th2-type cytokine secretion profile in a mammal, including administering a therapeutic amount of a12 analog peptide.
04/17/14
20140107539
Methods for treating heart arrhythmia
Methods and apparatus are provided for treatment of heart arrhythmia via renal neuromodulation. Such neuromodulation may effectuate irreversible electroporation or electrofusion, ablation, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
04/10/14
20140100286
Composition for preventing or treating inflammatory diseases comprising veratric acid as effective component
There is provided a composition including a veratric acid for preventing or treating inflammatory diseases. The veratric acid of the present invention has an excellent effect of inhibiting production of nitric oxide, an excellent activity of inhibiting production of il-1β as a pro-inflammatory cytokine, and an excellent effect of inhibiting phosphorylation of mapk, nf-κb, gsk-3β, and c-raf in a macrophage cell stimulated by a stimulation factor that causes an inflammatory reaction.
04/10/14
20140100262
Methods and compositions for maintaining blood-brain barrier integrity
Methods of maintaining or improving blood-brain barrier integrity and increasing resistance to cytokine-induced cell permeability are disclosed. It has been discovered that down-regulating the expression or production of sulfoglucuronyl glycolipids, for example sgpg, in endothelial cells of the blood-brain barrier or the blood-nerve barrier reduces apoptosis of these endothelial cells and thereby promotes the integrity of the barriers.
04/10/14
20140099714
Natural killer cell lines and methods of use
This invention relates to a natural killer cell line termed nk-92. The invention provides a vector for transfecting a mammalian cell which includes a nucleic acid sequence encoding a cytokine that promotes the growth of nk-92.
04/10/14
20140099294
Biotherapy for pain
The present invention is directed to analgesic clostridial neurotoxin derivatives comprising polypeptides having a long-lasting snare protein-selective endopeptidase activity. These derivatives selectively bind to and are internalized by non-neuronal cells secreting cytokines or sensory neurons in preference to motor neurons or autonomic neurons.
04/10/14
20140099282
Modulating innate immune cell activity by lunasin and selected cytokines
This disclosure provides compositions and methods for enhancing innate immune system activities and responses by combining lunasin with at least one cytokine. The compositions synergistically enhance the effect of these selected cytokine(s), including but not limited to, activating nk cells, augmenting nk's cytotoxicity against vinises and tumors, regulating nk-mediated anti-allergic inflammation, producing potent nk cells for cellular therapy using adoptive transfer, and facilitating dendritic cells antigen presentation..
04/10/14
20140099270
Method of use and preparation of hsa fusion protein composition for skincare
The present invention provides a recombinant fusion protein which stimulates the rejuvenation and reactivation of skin and epidermal cells for improving skin appearance, smoothing wrinkles and freckles, and whitening skin. Particularly, the present invention provides various types of products for improving skin, which contain recombinant fusion protein of human serum albumin (hsa) with cytokine peptides (egf, fgf, kgf, hgh, hgf, pdgf, gcsf, interferon, il-11 or igf) by genetic engineering technology.
04/03/14
20140093875
Mammalian cytokines; receptors; related reagents and methods
Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine il-b50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided.
04/03/14
20140093476
Methods for treating pain
Methods of treating pain by delivery of anti-inflammatory cytokines, proinflammatory cytokine antagonists, and agents that act to reduce or prevent proinflammatory cytokine actions, to the nervous system are described. These agents can be delivered using gene therapy techniques.
03/27/14
20140088567
Compositions and methods for removing ascitic fluid from the abdomen
The present invention features devices that can be used to extract ascites and other fluids from the body with a minimally invasive procedure and, if desired, can also be used to flush the cavity (e.g., the abdominal cavity) from which the fluids were removed. The devices also permit characterization of the fluids in that a surgeon or other health care provider can conveniently obtain a sample of the fluids to assess their composition.
03/27/14
20140087399
Assay method for peptide specific t-cells
A method of assaying for peptide-specific t-cells comprises adding peptide to a fluid sample of fresh peripheral blood mononuclear cells, and detecting a cytokine such as interferon-y produced by t-cells that have been pre-sensitised to the peptide. The assay method is quick and cheap and is expected to be useful for the study of various disease states including hepatitis b, hepatitis c, tuberculosis, malaria, hiv and influenza..
03/27/14
20140087009
Composition of beta-glucan and ashwagandha
Compositions including combinations of β-glucan and withania somnifera for increasing the immune activity of certain target cytokines and phagocytosis, and reducing cortisol or corticosterone. Methods of improving immunity activity under periods of stress including chronic stress with a combination of β-glucan and withania somnifera are also described.
03/27/14
20140086960
Immunomodulatory compounds and treatment of diseases related to an overproduction of inflammatory cytokines
R1 and r2 each designate an acyl group derived from a saturated or unsaturated, straight-or branched-chain carboxylic acid having from 2 to 18 carbon atoms, which is unsubstituted or bears one to three substituents selected among hydroxyl, dihydroxyphosphoryloxy, alkyl of 2 to 18 carbon atoms, alkoxy of 2 to 18 carbon atoms, acyloxy of 2 to 18 carbon atoms in the acyl moiety, amino, acylamino.. .
03/27/14
20140086915
Agents and methods for modulating macrophage inhibitory cytokine (mic-1) activity
The invention relates to a method and novel types of agents for modulating appetite and/or body weight in a subject. Moreover, the invention relates to a method of screening for agents which interact and modulate the activity of the receptor complex for macrophage inhibitory cytokine-1 (mic-1)..


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Cytokine topics: Antibodies, Inflammation, Specificity, Immunotherapy, Major Histocompatibility Complex, Compatibility, Combination Therapy, Histocompatibility, Immune Response, Monoclonal Antibody, Stimulator, Therapeutics, Immunostimulator, Monoclonal, Proinflammatory

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This listing is a sample listing of patent applications related to Cytokine for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Cytokine with additional patents listed. Browse our RSS directory or Search for other possible listings.
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