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Cytokine

Cytokine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Immunomodulation by controlling elr+ proinflammatory chemokine levels with the long non-coding rna umlilo
Csir
December 07, 2017 - N°20170349898

The present invention relates to methods for modulating the production of elr+ proinflammatory chemokines in a subject or a cell using either umlilo incrna inhibitors to decrease production of elr+ proinflammatory cytokines or using umlilo incrna's to increase the production of elr+ proinflammatory cytokines. The invention also provides for the use of umlilo incrna inhibitors or umlilo incrna's to modulate ...
Adjuvants useful for stimulation of immunity to tumor endothelial cells
Batu Biologics, Inc.
December 07, 2017 - N°20170348388

Adjuvants acting at the level of antigen presentation useful for stimulation of specific immunity against tumor endothelial cells. In one embodiment the invention teaches the use of activation of specific antigen presenting cell programs to selectively induce cytotoxic t cells and antibodies with complement activating ability while not evoking antigenic responses that potentially stimulate angiogenesis or growth of tumor endothelial ...
Lyophilized platelet lysates
Jadi Cell Llc
December 07, 2017 - N°20170348355

The present disclosure is drawn to compositions and methods of making and using lyophilized platelet lysates. Specifically, a method of preparing a composition suitable for therapeutic use or as a culture medium can comprise steps of concentrating platelets from a platelet source to form a platelet rich portion of the platelet source, and lysing the platelets in the platelet rich ...
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Cytokine Patent Applications
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Methods and apparatus for monopolar renal neuromodulation
Medtronic Ardian Luxembourg S.a.r.l.
December 07, 2017 - N°20170348050

Methods and apparatus are provided for monopolar neuromodulation, e. G., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers ...
Anti il-34 antibodies
Institut National De La Sante Et De La Recherche Medicale (inserm)
November 30, 2017 - N°20170342148

The present disclosure relates to novel anti il-34 antibodies or antigen-binding fragments thereof specifically binding cytokine il-34 with high affinity, the method of obtaining of these antibodies and their therapeutic use.
Heteroaryl inhibitors of pde4
Tetra Discovery Partners, Llc
November 30, 2017 - N°20170342094

The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (pde4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.
Cytokine Patent Pack
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Cytokine Patent Applications
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inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Chimeric compounds targeting proteins, compositions, methods, and uses thereof
Biotheryx, Inc.
November 23, 2017 - N°20170334932

The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, tnf-alpha activity, ck1-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, ...
Chimeric compounds targeting proteins, compositions, methods, and uses thereof
Biotheryx, Inc.
November 23, 2017 - N°20170333443

The present invention provides chimeric compounds that modulate protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, tnf-alpha activity, ck1-alpha activity and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, ...
Phytochemical compositions including sesamin for anti-inflammatory, anti-cytokine storm, and other uses
Commission On Higher Education
November 23, 2017 - N°20170333390

A composition (e. G., phytochemical composition) including sesamin, the composition exhibiting anti-inflammatory, anti-cytokine storm, connective tissue preservation, anti-viral, and/or other properties in biological tissue. The phytochemical composition therapeutically affects a pro-inflammatory cytokine condition, for instance facilitating or effectuating decrease in a quantity of a pro-inflammatory cytokine, for example, interleukin-1 and tumor necrosis-alpha. The phytochemical composition facilitates or effectuates an ...
Pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing biguanide derivative compound ...
The Catholic University Of Korea Industry-academic Cooperation Foundation
November 23, 2017 - N°20170333370

The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of il-17 and tnf-α, which are inflammatory cytokines, increases the activity of regulatory t cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune ...
Composition to induce bone marrow stem cell mobilization
Universitá Degli Studi Di Padova
November 16, 2017 - N°20170327573

A pharmaceutical composition to induce bone marrow stem cell mobilization from the bone marrow to peripheral blood in patients suffering from pathological conditions, such as diabetes, or subjected to treatments that impair cell mobilization, or in patients suffering from the so called “poor mobilizer” condition, includes at least one therapeutic agent that inhibits production and/or ...
Treatment of acute exacerbations of chronic obstructive pulmonary disease by antagonism of the il-20r
Universite De Droit Et De La Sante De Lille 2
November 16, 2017 - N°20170327572

The present invention relates to methods and pharmaceutical compositions for the treatment of acute exacerbation of chronic obstructive pulmonary disease. In particular, the present invention relates to a method of treating acute exacerbation of chronic obstructive pulmonary disease in a subject in need thereof comprising administering the subject with a therapeutically effective amount of an antagonist of il-20 cytokines.
Chemokine-cytokine fusion proteins and their applications
National Chung Hsing University
November 16, 2017 - N°20170327554

The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a tnf-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has ...
Cytokine Patent Pack
Download 175+ patent application PDFs
Cytokine Patent Applications
Download 175+ Cytokine-related PDFs
For professional research & prior art discovery
inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods of producing a zcytor17 heterodimeric cytokine receptor
Zymogenetics, Inc.
November 09, 2017 - N°20170320931

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods ...
Icos binding proteins
Zymogenetics, Inc.
November 02, 2017 - N°20170313777

The present invention relates to an icos binding protein or antigen binding portion thereof that is an agonist to human icos and does not induce complement, adcc, or cdc when placed in contact with a t cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said icos binding protein or antigen binding portion thereof. Further ...
Gitrl single chain molecules
Zymogenetics, Inc.
November 02, 2017 - N°20170313752

The present invention refers to single-chain fusion proteins comprising three soluble tnf superfamily (tnfsf) cytokine domains and nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications.
Isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof
Zymogenetics, Inc.
November 02, 2017 - N°20170313676

Provided are an isoindoline derivative, intermediate, preparation method, pharmaceutical composition and use thereof. The isoindoline derivative and the pharmaceutical composition thereof can regulate the production or activity of immunological cytokines, thus effectively treating cancer and inflammatory disease.
Cytokines and neuroantigens for treatment of immune disorders
Zymogenetics, Inc.
November 02, 2017 - N°20170312358

The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided.
Pharmaceutical composition for cancer prevention and treatment, containing ndrg3 expression or activity inhibitor as active ...
Korea Research Institute Of Bioscience And Biotechnology
October 26, 2017 - N°20170306047

The present invention relates to a pharmaceutical composition for preventing and treating cancer or inflammatory disease, containing an ndrg3 expression or activity inhibitor as an active ingredient. Furthermore, the present invention relates to an ndrg3 protein-specific antibody and a use thereof. Specifically, the antibody to the ndrg3 protein is prepared, and the antibody is used to verify that ndrg3 mediated ...
Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue
Ipsen Pharma S.a.s.
October 26, 2017 - N°20170304403

The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hghrelin.
Compositions and methods for treating lung remodeling diseases
Ipsen Pharma S.a.s.
October 19, 2017 - N°20170296589

In one aspect, the present disclosure can relate to a method for treating a lung remodeling disease in a subject. One step of the method can include assaying one or more mesenchymal stem cells (mscs) for one or more of the following effects: (1) reduce collagen deposition in the lungs of the subject; (2) increase expression of a transcription factor in an ...
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