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Cytokine patents



      
           
This page is updated frequently with new Cytokine-related patent applications. Subscribe to the Cytokine RSS feed to automatically get the update: related Cytokine RSS feeds. RSS updates for this page: Cytokine RSS RSS


Date/App# patent app List of recent Cytokine-related patents
08/21/14
20140235829
 Compositions and methods for regulation of tumor necrosis factor-alpha patent thumbnailCompositions and methods for regulation of tumor necrosis factor-alpha
The present invention relates to compositions and methods relating to an interleukin 18-inducible cytokine termed tumor necrosis factor-alpha inducing factor (taif) or interleukin-32 (il-32). In particular, the present invention provides compositions and methods for treating autoimmune diseases and cancer, in part by regulation of tumor necrosis factor-alpha expression..
08/21/14
20140234451
 Pharmaceutical composition comprising extract of puerariae flos for prevention and treatment of endometriosis patent thumbnailPharmaceutical composition comprising extract of puerariae flos for prevention and treatment of endometriosis
The present invention relates to a pharmaceutical composition containing puerariae flos extracts as active ingredients for preventing or treating endometriosis and the complications thereof. More particularly, puerariae flos extracts exhibit the activity of inhibiting the migration and adhesion of endometriosis cells, inhibiting the expressions of mmp-2 and mmp-9, which are factors associated with migration and adhesion, inhibiting the expression of cox-2, which is a factor associated with pain, and inhibiting the expression of mcp-1, which is a cytokine associated with inflammation, and rantes.
08/21/14
20140234297
 Antibody constant domain regions and uses thereof patent thumbnailAntibody constant domain regions and uses thereof
The invention provides recombinant protein (e.g., a recombinant antibody or soluble receptor) having (i) a binding domain capable of specific binding to an epitope (for example an antibody variable domains, a receptor, a growth factor, a cytokine, or a fragment of any of the foregoing which is capable of specifically binding the desired epitope) and (ii) an effector domain comprising a constant domain region which is derived from immunoglobulin of a first species which is a companion mammal, e.g. Dog, cat, or horse, having engineered substitutions at one or more positions and having an altered interaction with one or more fcrs or other ligands, and optionally enhanced effector function, relative to the parent constant domain region..
08/21/14
20140231357
 Methods for removing cytokines from blood with surface immobilized polysaccharides patent thumbnailMethods for removing cytokines from blood with surface immobilized polysaccharides
The present invention is directed to a method for removing cytokines and/or pathogens from blood or blood serum (blood) by contacting the blood with a solid, essentially non microporous substrate which has been surface treated with heparin, heparan sulfate and/or other molecules or chemical groups (the adsorbent media or media) having a binding affinity for the cytokine or pathogen(s) to be removed (the adsorbates), and wherein the size of the interstitial channels within said media is balanced with the amount of media surface area and the surface concentration of binding sites on the media in order to provide adequate adsorptive capacity while also allowing relatively high flow rates of blood through the adsorbent media.. .
08/21/14
20140230839
 Personal care compositions comprising a multi-active system for down regulating cytokines irritation patent thumbnailPersonal care compositions comprising a multi-active system for down regulating cytokines irritation
A personal care composition comprising a multi-active system for down regulating cytokines comprising at least three actives, an extract of camellia sinesis, panthenol, and a glycyrrhizinate salt.. .
08/14/14
20140228427
 Pharmaceutical composition containing wogonin as an active ingredient for preventing or treating asthma patent thumbnailPharmaceutical composition containing wogonin as an active ingredient for preventing or treating asthma
The present invention relates to a pharmaceutical composition for the prevention or treatment of asthma comprising wogonin as an active ingredient. The wogonin of the present invention is excellent not only in relieving airway hypersensitivity that causes asthma in vivo, in inhibiting reactive oxygen species generation in the airway, and in inhibiting the infiltration of inflammatory cells in the bronchus, but also in inhibiting the generation of ige in serum and bronchoalveolar lavage fluid, and in inhibiting the expressions of th2 cytokines in the lung.
08/14/14
20140227317
 Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom patent thumbnailHeterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
Conjugates of an immune response modifier, a linker, and an antigen are disclosed. The linker is represented by formula (i): wherein a is ch or n, p is in a range from 1 to 50, r″ is a bond or -alkylene-o—, r′ is alkylene that is optionally interrupted or terminated with one or more amide or ether groups, and e is an amine- or thiol-reactive group.
08/07/14
20140222163
 Artificial dura mater and manufacturing method thereof patent thumbnailArtificial dura mater and manufacturing method thereof
Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer.
08/07/14
20140220675
 Platform of dendritic cell (dc)-based vaccination patent thumbnailPlatform of dendritic cell (dc)-based vaccination
The present invention discloses novel dendritic cell maturation-inducing cytokine cocktails, and methods for inducting type-1 polarized dendritic cells in serum-free conditions which enhance the desirable properties of dc1s generated in serum-supplemented cultures. The invention further discloses methods and systems using ifnγ and other ligands of the ifnγ receptor, in combination with ifnα (or other type i interferons), poly i:c, and other ifnα (and ifnβ) inducers to enhance the il-12-producing properties of dendritic cells.
08/07/14
20140220618
 Measuring embryo development and implantation potential with timing and first cytokinesis phenotype parameters patent thumbnailMeasuring embryo development and implantation potential with timing and first cytokinesis phenotype parameters
Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans..
08/07/14
20140220603
Compositions and methods for detecting microbial infections
Provided herein are vaccine compositions for control of trypanosoma cruzi infection and chagas disease. The compositions comprise plasmids encoding o gpi-anchored genes asp-2, tcg-1, tcg2 and tcg4 from trypanosoma cruzi; plasmids encoding cytokines il12 and gm-csf; and plasmids encoding a gene expression system.
08/07/14
20140219920
Immunocytokine combination therapy
Methods and compositions for treating tumours, especially skin tumours, by locally administering single doses of tumour necrosis factor alpha (tnfα) and interleukin-2 (il2) at the tumour site, where the tnfα and il2 are delivered as immunoconjugates comprising an antibody targeted to a splice isoform of an extracellular matrix component such as fibronectin.. .
07/31/14
20140213466
High-throughput assessment method for contact hypersensitivity
The present invention provides methods for high-throughput assessment of in vivo skin sensitizing activity of chemical compounds through detection of secretion levels of cytokine markers implicated in skin sensitization in combination with a multivariate analysis, using support vector machine (svm) for feature selection. The invention includes a computational algorithm that will provide unbiased analysis on the skin cell secretome data and predict the level of skin sensitization.
07/31/14
20140212899
Method for noninvasive prediction or diagnosis of inflammation and infection in amniotic fluid of patients with premature rupture of membranes
Provided is a method for noninvasive prediction or diagnosis of inflammation and/or infection in amniotic fluid leaked through the cervix into the vagina to predict the concentration of inflammatory markers in the amniotic fluid inside uterus by measuring the concentration of inflammatory markers (various cytokines). Further provided is a method for prediction or diagnosis of inflammation and/or infection in amniotic fluid by measuring the concentration of markers (il-6, il-1β il-8, mcp-1, gro-α) in the amniotic fluid leaked through the cervix into the vagina in patients with premature rupture of membranes.
07/31/14
20140212876
Targeting c-rel o-glcnacylation and uses thereof
Serine 350 has been identified as the site of o-glycnacylation of c-rel. Methods are provided for identifying compositions capable of blocking c-rel activation.
07/24/14
20140206758
Expression of il-12 family heterodimers
The present invention provides methods of improving the levels and stability of expression of interleukin-12 family cytokine polypeptides by expressing the alpha and beta subunits of the polypeptides at their determined relative molar ratios that increase the levels and stability of expression of the heterodimer, e.g., in comparison to heterodimer expressed at an equimolar ratio.. .
07/24/14
20140206738
Lipase inhibitors
Is useful in the treatment and prevention of a disorder such as cachexia, stroke, atherosclerosis, coronary artery disease, and diabetes and pharmaceutical compositions of the same. Also, a method of screening for lipase inhibitors using a compound of formula (i) and determining its lipase inhibitory activity.
07/24/14
20140205684
Macrophage inhibitory cytokine-1 (mic-1) as a prognostic marker in chronic kidney disease
The present invention relates to methods of prognosing the survival of a diseased subject, particularly a subject with chronic kidney disease (ckd), as well as selecting an end-stage renal disease subject for a kidney transplant. The methods involve detecting an elevated amount of macrophage inhibitory cytokine-1 (mic-1) in a test body sample from the diseased subject.
07/24/14
20140205660
Abscisic acid against cancer
Abscisic acid (aba) a naturally occurring plant hormone has been identified in this invention with potent properties to fight cancer. Aba is able to produce a hyperpolarization condition on plasma membrane through a decrease of intracellular na+ and k+.
07/24/14
20140205658
Compositions and methods for treating or preventing radiation- or chemotherapy-induced pulmonary dysfunction
Compositions comprising one or more cytokines and methods for their use in inhibiting and/or alleviating effects of radiation therapy and/or chemotherapy and/or acute radiation syndrome in a subject in need thereof are provided.. .
07/24/14
20140205647
Method for treating defective dura mater
Disclosed are an artificial dura mater and manufacturing method thereof. The artificial dura mater includes electrospun layers prepared by electrostatic spinning, at least one of which is a hydrophobic electrospun layer.
07/24/14
20140205584
Anti-tnf-alpha therapy for the mucopolysaccharidoses and other lysosomal disorders
The present invention relates to methods of treating a subject with a lysosomal disorder, by administering an agent for enzyme replacement therapy and an agent for anti-tnf-α therapy; by administering a pentosan polysulfate therapy; or by administering a substrate reduction therapy and an anti-tnf-α therapy. The invention further relates to a method of reducing inflammatory cytokines in a subject with a lysosomal disorder that is being treated by enzyme replacement therapy, by administering an agent for anti-tnf-α therapy..
07/24/14
20140205565
Compositions and methods for treating organ dysfunction
A method of retarding cellular senescence comprising (i) providing an extracellular matrix (ecm) composition comprising ecm from an adolescent tissue source, the ecm comprising an exogenously added cytokine, and (ii) administering ecm composition to an organ with cells exhibiting cellular senescence, wherein, the cytokine interacts with at least one molecule in the ecm composition and modulates ros production of the cells, whereby, the cellular senescence is abated.. .
07/24/14
20140205563
Compositions derived from stem cell released molecules & methods for formulation thereof
Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (srm's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and srm's can be derived from one or more distinct cell lines.
07/17/14
20140199322
Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.. .
07/10/14
20140194628
Substituted imidazo ring systems and methods
Imidazo ring systems substituted at the 1-position, pharmaceutical compositions containing the compounds, intermediates, methods of making the compounds, and methods of use of these compounds as immunomodulators, for inducing cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.. .
07/10/14
20140193529
Modulation of thymosin beta-4 in skin
Methods for preventing, ameliorating, or reducing dermatological signs of inflammation are provided which employ active agents, other than a retinoid, that stimulate thymosin beta-4 expression in the skin and inhibit production of pro-inflammatory chemokines and/or cytokines. Also provided are methods for screening for substances which stimulate thymosin beta-4 expression levels and the methods of using active agents identified by the screening protocol in the treatment of skin..
07/10/14
20140193411
Multimeric constructs
Multimeric fusion proteins of an ig-like domain of flt-1 are rendered functional by inclusion of a linker moiety. Vectors encoding the fusion proteins and host cells expressing the fusion proteins can be used therapeutically to block neovascularization in individuals with pathological conditions related to neovascularization.
07/10/14
20140193361
Systemic glucose tolerance in type-2 diabetes
Obesity is associated with a state of chronic low-grade inflammation and the present invention establishes that adipose-resident natural killer t (nkt) cells attenuate inflammation in adipose tissue and improves systemic glucose homeostasis in mice at different stages of obesity. Accordingly, the present invention provides methods of treating type-2 diabetes or those at risk for type-2 diabetes using activators of adipose-resident nkt cells.
07/03/14
20140187845
Radio-immuno-modulation treatment for advanced cancer and monitoring tolerance and cellular immune response at the tumor site
A combination therapy for treating advanced cancer, comprises, first, performing targeted low dose radiation therapy on a recipient tumoral site to generate an inflammation zone and an immuno-stimulant effect, including release of cytokines and chemokines. Secondly, hematopoietic cells from a suitable donor are administered intravenously in order to initiate an allogeneic reaction.
07/03/14
20140186319
Notch induced natural killer cell generation and therapeutic uses
A method of preparing differentiated nk cells by ex vivo expansion includes the steps of; (1) isolating a plurality of cd34+ hematopoietic cells; (2) culturing the cells in a medium, wherein the medium includes an effective amount of a notch ligand and one or more cytokines selected from the group consisting of il-7, il-15, scf, flt-3, il-3 and il-6; and (3) maintaining the cells in culture for a duration of time sufficient to produce nk cells.. .
06/26/14
20140178987
Stem cell culture medium and its applications as well as a stem cell culture method
The present invention discloses a stem cell culture medium and its applications as well as a stem cell culture method. The said stem cell culture medium contains no serum.
06/26/14
20140178367
Methods of treating inflammatory diseases by targeting the chemoattractant cytokine receptor 2 (ccr2) or chemokine (c-c motif) ligand 2 (ccl2)
Methods of treating inflammatory diseases, e.g., diseases associated with inflammatory cd14+/cd16− monocytes, e.g., amyotrophic lateral sclerosis (als), stroke, and glaucoma, using compounds such as small molecules and antibodies that target ccr2 or ccl2.. .
06/19/14
20140172054
Methods and apparatus for bilateral renal neuromodulation
Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
06/19/14
20140170658
Mammalian cytokines; related reagents
Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided..
06/19/14
20140170171
Targeted cytokine for treatment of musculoskeletal diseases
Provided are proteins and polynucleotides, complexes and compositions containing the proteins, and methods for their use in administration to subjects and for disease treatment. Among the provided proteins and complexes are complexes containing a tgf-beta associated with immunoglobulins (such as iggs) or functional portions thereof including fc portions, such as by non-covalent bonds.
06/19/14
20140170120
Cytokine induction of selectin ligands on cells
Methods and compositions for treating cells with cytokines are provided herein.. .
06/19/14
20140170109
Il-12 immunoconjugate
Conjugate comprising interleukin-12 (il-12) and a single chain targeting portion comprising two antigen binding sites. The targeting portion may comprise an antibody fragment such as a single chain diabody.
06/12/14
20140163204
Derivatives of growth hormone and related proteins
The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins.
06/12/14
20140161766
Tetrameric cytokines with improved biological activity
The present invention concerns methods and compositions for forming cytokine-antibody complexes using dock-and-lock technology. In preferred embodiments, the cytokine-mab dnl complex comprises an igg antibody attached to two ad (anchor domain) moieties and four cytokines, each attached to a ddd (docking and dimerization domain) moiety.
06/05/14
20140154220
Methods and compositions for improved tissue regeneration by suppression of interferon-gamma and tumor necrosis factor-alpha
The present invention discloses methods, compositions and devices for improving tissue regeneration by suppressing the effects of several proinflammatory cytokines such as tnf-α and ifn-γ. Compositions and devices of this invention will generally include one or more anti-inflammatory agent(s) capable of reducing the level of tnf-α, ifn-γ, or both.
06/05/14
20140154215
Herpes virus strains
The present invention provides a herpes virus with improved oncolytic properties which comprises a gene encoding an immunomodulatory cytokine and which lacks a functional icp34.5 gene and a functional icp47 encoding gene.. .
06/05/14
20140154207
Kit containing stem cells and cytokines for use in attenuating immune responses
The present invention relates to a composition and methods of treatment for inflammation comprising of adult stem cells and inflammatory cytokines. The invention further relates to the treatment of inflammation associated with autoimmune disorders, allergies, sepsis, cancer as well as to preventing, reducing or treating transplant rejection and/or graft-versus-host disease (gvhd)..
05/29/14
20140148394
Compositions and methods for modulating gamma-c-cytokine activity
The various embodiments relate to peptide antagonists of γc-family cytokines, interleukin-2 (il-2), interleukin-4 (il-4), interleukin-7 (il-7), interleukin-9 (il-9), interleukin-15 (il-15), and interleukin-21 (il-21). The γc-cytokines are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd).


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Cytokine topics: Antibodies, Inflammation, Specificity, Immunotherapy, Major Histocompatibility Complex, Compatibility, Combination Therapy, Histocompatibility, Immune Response, Monoclonal Antibody, Stimulator, Therapeutics, Immunostimulator, Monoclonal, Proinflammatory

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This listing is a sample listing of patent applications related to Cytokine for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Cytokine with additional patents listed. Browse our RSS directory or Search for other possible listings.
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