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Cytokine

Cytokine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Composition and methods of using umbilical cord lining stem cells
August 17, 2017 - N°20170233697

The invention provides methods for using umbilical cord lining stem cells (ulscs) to produce therapeutic factors including growth factors, cytokines, chemokines and extracellular matrix components. Ulscs are mesenchymal stem cells isolated from umbilical cord lining. They can be efficiently propagated and expanded in vitro. Under specific conditions ulscs produce useful therapeutic factors that can be used to treat injuries and ...
Cell culture media composition and methods of producing thereof
Neuclone Biologics Pty Ltd
August 17, 2017 - N°20170233695

A serum free cell culture media, wherein the media is adapted to be conditioned by culturing a first set of eukaryotic cells in the media, wherein the first set of eukaryotic cells use an expression vector to excrete levels of desired complex proteins into the media; wherein said desired complex proteins include human growth hormone (hgh), growth hormone-like growth factors, ...
Methods of treating inflammation using il-17a and il-17f cross-reactive monoclonal antibodies
Zymogenetics, Inc.
August 17, 2017 - N°20170233498

The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of il-17a and il-17f. Il-17a and il-17f are cytokines that are involved in inflammatory processes and human disease. The present invention includes antibodies that bind both il-17a and il-17f, as well as methods of using the same in inflammation.
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Subcutaneously administered bispecific antibodies for use in the treatment of cancer
Medtronic Ardian Luxembourg S.a.r.l.
August 10, 2017 - N°20170224818

The present invention relates to the use of t cell redirecting, bispecific, in particular trifunctional, antibodies for the treatment of a cancer disease, wherein said antibody is administered via the subcutaneous route. Thereby, the release of proinflammatory cytokines is reduced and, simultaneously, the release of inhibitory cytokines is substantially suppressed. That treatment by bispecific, in particular trifunctional, antibodies may be ...
Nutritional support method for health issues
Cortcontrol
August 10, 2017 - N°20170224746

A method of improving the outcome or recovery for depression, diabetes, cardiovascular disease, alzheimers progression, or breast cancer. This method consists of administering a food which includes transfer factor, lactic acid generating bacteria, and/or glucans in appropriate combinations and dosage levels. The food reduces cortisol levels, enhances the immune system, and balances hormones and cytokines. Dosage amounts are dependent ...
Methods for treating nervous system injury and disease
Noveome Biotherapeutics, Inc.
August 10, 2017 - N°20170224740

The invention is directed to methods for treating nervous system injury and disease, in particular traumatic brain injury and degenerative nervous system disease. Such methods utilize novel compositions, including but not limited to trophic factor-secreting extraembryonic cells (herein referred to as tse cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as amp cells) and conditioned ...
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Cytokine Patent Applications
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inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Use of hla genetic status to assess or select treatment of celiac disease
Immusant, Inc.
August 03, 2017 - N°20170218453

Provided herein are methods of adjusting or selecting a gluten peptide therapy based on the human leukocyte antigen (hla) genotype, in particular hla-dq2. 5 homozygosity, of a subject having or suspected of having celiac disease. Also provided herein are methods of identifying (e. G., diagnosing) a subject, such as a subject having or suspected of having celiac disease and/or assessing ...
N-terminally truncated interleukin-38
Fraunhofer-gesellschaft Zur FÖrdeung Angewandten Forschung E.v.
August 03, 2017 - N°20170218039

The present invention pertains to an n-terminally truncated interleukin (il)-38 protein, or functional variants thereof, as well as to nucleic acids and vectors encoding the truncated il-38 peptide and recombinant cells comprising these nucleic acids or vectors. The invention shows that il-38 is n-terminally processed and that the truncated version of the cytokine acts as an antagonist of immune ...
Methods and compositions for enhancing t cell function and survival
Augusta University Research Institute, Inc.
August 03, 2017 - N°20170216355

It has been discovered that the inhibition of pi3k-δ, but not pi3k-α or pi3k-β, delays the terminal differentiation of cd8 t cell and maintains the tcm phenotype thus enhancing their proliferative ability and survival while maintaining their cytokine and granzyme b production ability. Methods and compositions for delaying or inhibiting terminal ...
Method of treating scoliosis using a biological implant
Augusta University Research Institute, Inc.
August 03, 2017 - N°20170215921

The present invention is a bone growth stimulating and promoting cytokine type biological implant preferably comprising pth coated with a controlled release biodegradable coating that is implanted preferably in the concave side of a scoliotically curved spine in combination with a bone growth inhibiting type biological implant preferably comprising methotrexate or like anti-metabolite coated with a controlled release biodegradable coating ...
Inflammation reporter system
National University Corporation Gunma University
August 03, 2017 - N°20170215394

The present invention provides a method for detection of an inflammatory reaction, which comprises using a transformant or transgenic non-human animal transfected with a vector comprising a promoter for a gene encoding an inflammatory cytokine, a gene encoding a reporter protein, a gene encoding the inflammatory cytokine, and a gene encoding a proteolytic signal sequence to thereby detect an inflammatory ...
Filter module
Gambro Lundia Ab
July 27, 2017 - N°20170209636

The present disclosure relates to a filter module for a medical fluid delivery system capable of removing cytokine inducing substances (cis) from a medical fluid.
Method for preparing dendritic cells with increased specific gene expression, and composition for treating or ...
Jw Creagene Inc.
July 27, 2017 - N°20170209557

The present invention relates to a method for generating semi-mature dendritic cells by treating immature dendritic cells with the auto-antigen, cytokine, and pge2 as a target for the treatment of autoimmune diseases, particularly rheumatoid arthritis, in which the levels of nr4a2 and/or ubash3b at gene or protein are increased more than 2-fold compared to the immature dendritic ...
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Download 175+ patent application PDFs
Cytokine Patent Applications
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For professional research & prior art discovery
inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods of diagnosing and prognosing colonic polyps
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
July 20, 2017 - N°20170205413

Methods of diagnosing or prognosing a disease or condition associated with increased or over expression of macrophage inhibitory cytokine-1 (mic-1) are disclosed. The methods typically involve detecting a change in the amount of mic-1 in a test body sample from a subject taken at two or more time points. The change in the amount of mic-1 may be adjusted for ...
Zcytor17 heterodimeric cytokine receptor monoclonal antibodies
Zymogenetics, Inc.
July 20, 2017 - N°20170204190

Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods ...
Method of designing a peptide and/or peptide derivative for modulating gamma-c-cytokine activity
Bioniz, Llc
July 20, 2017 - N°20170204153

The γc-family cytokines, interleukin-2 (il-2), interleukin-4 (il-4), interleukin-7 (il-7), interleukin-9 (il-9), interleukin-15 (il-15), and interleukin-21 (il-21), are associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. ...
Combination drug therapies for cancer and methods of making and using them
Vicus Therapeutics, Llc
July 20, 2017 - N°20170202806

In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices for treating, preventing or ameliorating a tumor or a cancer, and methods and uses for treating, preventing or ameliorating a tumor or a cancer. In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices comprising: a beta adrenergic receptor antagonist (a “beta ...
Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders
Novartis Ag
July 13, 2017 - N°20170198035

The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine il-17 a. The disclosure more specifically relates to specific antibodies and proteins that are il-17 a antagonists (inhibit the activities of il-17 a and il-17 af) and are capable of inhibiting il-17 a induced cytokine production in in vitro assays, ...
Composition for treating sepsis or septic shock comprising the peptide originated from the smad6
Medpacto, Inc.
July 13, 2017 - N°20170198011

Disclosed is a pharmaceutical composition comprising a smad6-derived peptide as an active ingredient. Having ability to specifically bind to pellino-1, the smad6-derived peptide is effectively useful in the treatment of the sepsis mediated by excessively activated tlr. The peptide effectively reduces the expression of inflammatory cytokines, protects cells from sepsis-induced apoptosis, and exhibits high bacterial clearance in animal ...
Method for producing autologous tolerogenic dendritic cells (toldcs) with specific antigens and their use in ...
Pontificia Universidad Catolica De Chile
July 13, 2017 - N°20170196950

The invention relates to a method for producing tolerogenic dendritic cells (toldcs) with specific antigens, comprising the steps of: (a) culturing precursors of dendritic cells in an animal-serum-free medium, using cytokines, il-4 and gm-csf, in order to differentiate same in dendritic cells; (b) producing apoptotic cells; (c) culturing the dendritic cells obtained in step (b) in the presence of compounds ...
Combination drug therapies for cancer and methods of making and using them
Vicus Therapeutics, Llc
July 13, 2017 - N°20170196901

In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices for treating, preventing or ameliorating a tumor or a cancer, and methods for treating, preventing or ameliorating a tumor or a cancer. In alternative embodiments, provided are therapeutic combinations, pharmaceutical compositions, formulations, kits and devices comprising: a beta adrenergic receptor antagonist (a “beta blockerȁ...
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