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Cytokine

Cytokine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Rna-based compositions and adjuvants for prophylactic and therapeutic treatment
University Of Kentucky Research Foundation
June 22, 2017 - N°20170175122

The present invention is directed towards an artificial rna nanostructure comprising multiple external strands of rna, each external strand comprising about 40-50 nucleotides; one internal strand of rna comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a prna three-way junction (3wj) motif at ...
NEW Icos binding proteins
Glaxosmithkline Intellectual Property Development Limited
June 22, 2017 - N°20170174767

The present invention relates to an icos binding protein or antigen binding portion thereof that is an agonist to human icos and does not induce complement, adcc, or cdc when placed in contact with a t cell in vivo and methods of treating cancer, infectious disease and/or sepsis with said icos binding protein or antigen binding portion thereof. Further ...
NEW Hydrazino 1h-imidazoquinolin-4-amines and conjugates made therefrom
3m Innovative Properties Company
June 22, 2017 - N°20170173164

1h-imidazo[4,5-c]quinolin-4-amines substituted at the 1-position with a substituent bearing a hydrazinobenzamide or hydrazinonicotinamide, a salt thereof, or a protected hydrazinobenzamide or hydrazinonicotinamide and conjugates made from such compounds are disclosed. Pharmaceutical compositions containing the compound or the conjugate, methods of making a conjugate, and methods of use of the compounds or conjugates as immunomodulators for inducing cytokine ...
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Systems and methods for detecting infectious diseases
Theranos, Inc.
June 15, 2017 - N°20170168051

Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (pos) location and may be tested at the pos location for multiple markers for multiple diseases, including upper and lower respiratory diseases. Samples may be tested for cytokines, or for inflammation indicators. Dilution of samples, or levels of detection, may ...
Methods for diagnosing and treating neuroimmune-based psychiatric disorders
The Regents Of The University Of California
June 15, 2017 - N°20170166968

The methods of the present invention are useful for determining whether an individual has or is at risk of developing a neuroimmune-based psychiatric disorder by detecting the expression level of one or more cytokine receptors in a biological sample. The methods of the present invention are also useful for the in vivo imaging of brain tissue by detecting one or ...
Biologically optimized adult mesenchymal stem cells
The Regents Of The University Of California
June 15, 2017 - N°20170166869

The invention disclosed provides populations and compositions of mesenchymal stem and progenitor cells derived from adult tissues that are subjected to a process or processes designed to enhance a biological mechanism prior to implantation of the cells for therapeutic use. The processes involve preconditioning of said mesenchymal stem cells with a physiological stressor in vitro, so as to enhance therapeutically ...
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Cytokine Patent Applications
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inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Cancer-targeted il-12 immunotherapy
Merck Patent Gmbh
June 15, 2017 - N°20170166620

The invention is directed to cancer immunotherapy. The invention is specifically directed to the induction of innate or adaptive antitumor immunity initiated by the administration of targeted il-12 molecules preferably in conjunction with il-2 and/or il-7 to a cancer patient, who suffers from cancer of the muscle, bone, nerves, cartilage, tendons, blood vessels, etc., preferably from sarcoma. The invention ...
Agent containing imidazole dipeptide
National Center Of Neurology And Psychiatry
June 15, 2017 - N°20170165314

An anti-aging agent derived from a natural product is provided. The agent uses at least one selected from the group consisting of an imidazole dipeptide and a metabolite thereof as an active ingredient. The present invention also provides an agent for improving a neuropsychologic function, which contains at least one selected from the group consisting of an imidazole dipeptide and ...
Cysteamine in the treatment of fibrotic disease
Seattle Children's Hospital (dba Seattle Children' S Research Institute)
June 15, 2017 - N°20170165207

Fibrotic diseases are characterized by the replacement of healthy tissue with scar tissue and extracellular matrix in response to tissue damage. Here we describe the reduction of extracellular matrix (ecm) deposition, interstitial fibroblasts, interstitial volume, expression of collagen i mrna and protein, expression of profibrotic cytokines and macrophage infiltration by cysteamine treatment.
Compositions and methods for targeted immunomodulatory antibodies and fusion proteins
The Johns Hopkins University
June 08, 2017 - N°20170158770

The present invention is based on the seminal discovery that targeted immunomodulatory antibodies and fusion proteins can counter act or reverse immune tolerance of cancer cells. Cancer cells are able to escape elimination by chemotherapeutic agents or tumor-targeted antibodies via specific immunosuppressive mechanisms in the tumor microenvironment and such ability of cancer cells is recognized as immune tolerance. Such immunosuppressive ...
Antibody cytokine engrafted compositions and methods of use for immunoregulation
Novartis Ag
June 08, 2017 - N°20170158747

The present disclosure provides antibody cytokine engrafted proteins that bind to and stimulate intracellular signaling through interleukin 10 receptor. Provided antibody cytokine engrafted proteins find use in enhancing anti-inflammatory cell responses, and reducing pro-inflammatory effects in the treatment, amelioration and prophylaxis of immune related disorders. Additionally provided are polynucleotides and vectors that encode antibody cytokine engrafted proteins and host cells capable ...
Curcumin analogues as zinc chelators and their uses
Novartis Ag
June 08, 2017 - N°20170158605

Wherein α, β, x, y, and r1-r11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (mmp), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a ...
Mucin-associated surface protein as a vaccine against chagas disease
Board Of Regents, The University Of Texas System
June 08, 2017 - N°20170157227

Use of synthetic peptides derived from trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and chagas disease. T. Cruzi uses several surface proteins to invade the host. In their role of protection, the surface protients ensure the targeting and invasion of specific cells or tissues. A conserved region in the family of mucin-associated surface proteins (masp) was ...
Cytokine Patent Pack
Download 175+ patent application PDFs
Cytokine Patent Applications
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inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Camptothecin conjugates of anti-cd22 antibodies for treatment of b cell diseases
Immunomedics, Inc.
June 01, 2017 - N°20170151356

Disclosed herein are compositions and methods of use comprising combinations of anti-cd22 antibodies with a therapeutic agent. The therapeutic agent may be attached to the anti-cd22 antibody or may be separately administered, either before, simultaneously with or after the anti-cd22 antibody. In preferred embodiments, the therapeutic agent is an antibody or fragment thereof that binds to an antigen different from ...
Skin wound healing and scar reduction with prostaglandin ep4 agonist combinations
Allergan, Inc.
June 01, 2017 - N°20170151261

A combination of a prostaglandin ep4 agonist and an effective amount of: a prostaglandin ep2 agonist, a skin growth factor, a small peptide, a small inhibitory rna targeting excess chronic inflammation or fibrosis, a cytokine with beneficial anti-inflammatory activity, an adenosine a2a receptor agonist, an anti-oxidant, or a combination thereof, may be used to treat skin wounds or scars.
Compositions and methods of use of phorbol esters
Biosuccess Biotech Company, Ltd.
June 01, 2017 - N°20170151205

Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of cytopathic diseases. Cytopathic diseases may be caused by a variety means such as viral infections like hiv and aids in a mammalian subject. The methods and compositions of the invention are effective for inhibiting de novo hiv infection, upregulating viral ...
Use of compounds inhibiting apelin / apj / gp130 signaling for treating cancer
Biosuccess Biotech Company, Ltd.
May 25, 2017 - N°20170146518

Today, despite current advances in combinatorial therapies such as surgery, radiotherapy and chemotherapy, aggressive cancers remain fatal. Cancer stem-like cells (cscs) may account for chemotherapy resistance and thus represent a promising therapeutic target. In this context, the present inventors identified essential intracellular pathways favoring the self-renewal and survival of cscs. More precisely, the present inventors showed that the cytokine co-receptor ...
Vault complexes for cytokine delivery
Biosuccess Biotech Company, Ltd.
May 25, 2017 - N°20170143797

The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
Dendritic cell immune receptor activator, method for activating dendritic cell immune receptor, osteoclast formation inhibitor, ...
Biosuccess Biotech Company, Ltd.
May 25, 2017 - N°20170143754

Wherein, in the formula, a sialic acid does not exist at two non-reducing terminals, and each of x and y independently represents 3 or 4.
Novel piperazines, pharmaceutical compositions and methods of use thereof
The Feinstein Institute For Medical Research
May 18, 2017 - N°20170136007

Disclosed are novel piperazine derivatives that act as agonists of the a7 nachr. Also disclosed are pharmaceutical compositions, methods of treating inflammatory conditions, methods of treating cns disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.
Antibodies directed against cd127
Ose Immunotherapeutics
May 11, 2017 - N°20170129959

The invention relates to antibodies directed against cd127, the alpha chain of the interleukin 7 (il-7) receptor il-7r), and which have antagonist properties for il-7-il-7r interaction, may present cytotoxic activity against cd127 positive cells but do not increase the maturation of dendritic cells (dcs) induced by tslp, a cytokine also using cd127 as part of its receptor. Alternatively, ...
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