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Cytokine

Cytokine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Lymph node-targeting nanoparticles
Duke University
April 12, 2018 - N°20180099044

Provided are nanoparticles comprising heparin, chitosan, and at least one immunomodulatory agent, e. G. A cytokine. The cytokine can be selected from the group consisting of tnf, il-12, il-2, il-23, il-1α, il-10, il-18, and combinations thereof. Further provided are methods of making a nanoparticle comprising mixing a first composition comprising heparin with a second composition comprising chitosan in ...
Composition for preventing and treating pancreatitis containing naphthoquinone-based compound as active ingredient
Nadianbio
April 12, 2018 - N°20180098960

The present invention relates to a composition for the prevention and treatment of pancreatitis comprising a naphthoquinone-based compound, a pharmaceutically acceptable salt, a prodrug, a solvate, or an isomer of the same. Particularly, the naphthoquinone-based compounds β-lapachone and dunnione can reduce the pancreatic weight/body weight ratio, which is increased by pancreatitis; reduce the increased activities of digestive ...
Combination immune therapy and cytokine control therapy for cancer treatment
Enlivex Therapeutics Ltd.
April 05, 2018 - N°20180094244

Compositions disclosed herein, and methods of use thereof included those for inhibiting or reducing the incidence of cytokine release syndrome or cytokine storm in a subject undergoing car t-cell therapy, wherein the subjects are administered compositions including apoptotic cells or apoptotic cell supernatants. In certain instances compositions and methods of use thereof disclosed herein do not reduce the efficacy of ...
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System and method for healing and/or disinfecting wounds and burns
Gliese 623b, Llc
April 05, 2018 - N°20180093107

A system for healing and/or disinfecting wounds and burns includes an emitter including one or more blue light sources configured to emit blue light at a therapeutic energy level at a wound or burn area of a human or animal subject and one or more ultraviolet-a (uva) light sources configured to emit uva light at a therapeutic energy level ...
Targeted apheresis using binding agents or ligands immobilized on membranes
April 05, 2018 - N°20180093032

This invention teaches a method of targeted apheresis that can be used to treat a variety of different diseases including infectious diseases, autoimmune disorders, and reducing circulating biomarkers associated with certain disorders e. G. Pre-eclampsia. This invention discloses the use of apheresis membranes as the support matrix upon which one or more different binding agents (e. G. Antibodies, aptamers, binding ...
Therapeutic compositions for treatment of ocular inflammatory disorders
The Schepens Eye Research Institute, Inc.
April 05, 2018 - N°20180092976

The invention comprises a composition with means to inhibit the function of the inflammatory cytokine il-17 and methods for using this composition to treat il-17-mediated ocular inflammatory disorders. The invention also discloses devices for delivering this composition to the eye.
Cytokine Patent Pack
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Cytokine Patent Applications
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  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Cell therapy with polarized macrophages for tissue regeneration
Xcell Medical Solutions, S.l.
March 29, 2018 - N°20180087031

The invention provides an in vitro method for inducing macrophage polarization to an m2 phenotype useful for tissue repair. The method described in the present invention comprises the in vitro exposure of macrophages to repeated series of hypoxia-reoxygenation. Activated m2 macrophages obtained by this method overexpress molecules important for tissue remodeling and amelioration of inflammation, such as ngal and anti-inflammatory ...
Pharmaceutical composition for preventing or treating inflammatory diseases, containing lactococcus chungangensis as active ingredient
Chung-ang University Industry-academic Cooperation Foundation
March 29, 2018 - N°20180085409

The composition according to the present invention, which comprises lactococcus chungangensis as an active ingredient, has excellent effects of preventing or treating inflammatory diseases, inhibiting the secretion of nitric oxide and prostaglandin e2, which are major inflammatory factors, and inhibiting the secretion of β-hexosaminidase and histamine, which are major factors related to allergies, and also significantly suppressing the ...
Delivery of rna to trigger multiple immune pathways
Glaxosmithkline Biologicals, Sa
March 29, 2018 - N°20180085388

Rna encoding an immunogen is co-delivered to non-immune cells at the site of delivery and also to immune cells which infiltrate the site of delivery. The responses of these two cell types to the same delivered rna lead to two different effects, which interact to produce a strong immune response against the immunogen. The non-immune cells translate the rna and ...
Multivalent antibody complexes targeting igf-1r show potent toxicity against solid tumors
Ibc Pharmaceuticals, Inc.
March 22, 2018 - N°20180079816

The present invention concerns methods and compositions comprising an anti-igf-1r antibody or fragment thereof for treatment of cancer or autoimmune disease. Preferably, the cancer is renal cell carcinoma, breast cancer or pancreatic cancer. The anti-igf-1r antibody or fragment may be part of a complex, such as a dock-and-lock® (dnl®) (complex produced by binding interaction between anchor ...
Methods and apparatus for bilateral renal neuromodulation
Medtronic Ardian Luxembourg S.a.r.l.
March 22, 2018 - N°20180078758

Methods and apparatus are provided for bilateral renal neuromodulation, e. G., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation ...
Mast cell stabilizers for treatment of hypercytokinemia and viral infection
Emergo Therapeutics, Inc.
March 15, 2018 - N°20180072796

The present invention relates to methods for treating hypercytokinemia and viral infections associated with hypercytokinemia using a mast cell stabilizing compound, optionally in combination with an antiviral agent. The invention further relates to compositions and dosage forms comprising mast cell stabilizing agents, optionally with an antiviral agent.
Genetic modification of pigs for xenotransplantation
The Trustees Of Columbia University In The City Of New York
March 15, 2018 - N°20180070564

The invention provides for transgenic donor animals (e. G., pigs) whose cells, tissues and organs have a better long-term survival when transplanted into a human patient. The transgenic donor animal carries one or more human transgenes which is expressed only when the endogenous gene of the donor animal is knocked out shortly before a graft is harvested for transplantation. This &#...
Cytokine Patent Pack
Download 175+ patent application PDFs
Cytokine Patent Applications
Download 175+ Cytokine-related PDFs
For professional research & prior art discovery
inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Mast cell stabilizers for treatment of hypercytokinemia and viral infection
Emergo Therapeutics, Inc.
March 08, 2018 - N°20180066039

The present invention relates to methods for treating hypercytokinemia and viral infections associated with hypercytokinemia using a mast cell stabilizing compound, optionally in combination with an antiviral agent. The invention further relates to compositions and dosage forms comprising mast cell stabilizing agents, optionally with an antiviral agent.
Compounds targeting proteins, compositions, methods, and uses thereof
Biotheryx, Inc.
March 08, 2018 - N°20180065952

The present invention provides modulators of protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, ...
Site specific curcumin-polymer molecular complexes and methods of treating colon diseases and inflammation
South Dakota Board Of Regents
March 08, 2018 - N°20180064821

Methods and materials relating to a medicament preparation comprising a curcuminoid component, such as curcumin, and a polymer component having a backbone comprising polymethacrylate or methyl methacrylate provided as a curcuminoid-polymer complex, which enhances the solubility, stability and bioavailability of the curcumin component and are useful for the treatment of various inflammatory diseases and conditions when delivered to the gastro-intestinal ...
Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related ...
Pharmacogenetics Limited
March 08, 2018 - N°20180064773

Compositions comprising extracts prepared from mixtures of the herbal plants radix bupleurum chinense dc (“b”), rhizoma corydalis yanhusuo wt wang (“y”), caulis polygonum multiflorum thunb (“p”) and flos albizia julibrissin durazz (“a”) are provided. The byp, bya, bpa, by, bp, yp and bypa extracts ...
Methods of producing modified natural killer cells and methods of use
The United States Of America, As Represented By The Secretary, Department Of Health And Human
March 01, 2018 - N°20180057795

Disclosed herein are method of producing nk cells that include one or more heterologous nucleic acids. The methods include culturing a population of isolated nk cells in the presence of one or more cytokines to produce a population of activated nk cells. The population of activated nk cells are transduced with a viral vector comprising the one or more heterologous ...
Cytokine receptor genes and the use thereof to enhance therapy
Musc Foundation For Research Development
March 01, 2018 - N°20180057794

Cells, such a t-cells, are provided that comprise cytokine receptors having increased activity in response to their ligand. For example, cell can comprise il-2 and/or il-15 receptors having increased surface expression or signaling activity. Cells of the embodiments have a significant growth advantage in the presence of cytokines and can be used, e. G., for enhanced adoptive cell transfer ...
Dicam-specific antibodies and uses thereof
Centre Hospitalier De L'université De Montréal
March 01, 2018 - N°20180057590

Novel antibodies directed against dual ig domain containing cell adhesion molecule (dicam) are described. These anti-dicam antibodies are capable of detecting dicam by western blot and/or flow cytometry, blocking the interaction between dicam and its ligand αvβ3 integrin, and/or blocking the migration of inflammatory cytokine-secreting th17 lymphocytes across the blood brain barrier. Uses of ...
Antagonists of il-20 family of cytokines and their use
Clover Biopharmaceuticals
March 01, 2018 - N°20180057564

Methods for blocking the activity of the il-20 family of cytokines in a mammal having a disorder-mediated by one or more of the il-20 family of cytokines consisting of il-19, il-20 and il-24 are disclosed. The methods involve administering a therapeutically effective amount of either a soluble il-20r2-igg fc fusion protein or a neutralizing monoclonal antibody to il-20...
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