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Cytokine patents



      
           
This page is updated frequently with new Cytokine-related patent applications. Subscribe to the Cytokine RSS feed to automatically get the update: related Cytokine RSS feeds. RSS updates for this page: Cytokine RSS RSS


Toshiba America Electronic Components

Semiconductor memory with integrated biologic element

Date/App# patent app List of recent Cytokine-related patents
04/16/15
20150105400
 Therapeutic agent for cerebral infarction patent thumbnailnew patent Therapeutic agent for cerebral infarction
The present invention provides a novel therapeutic drug for cerebral infarction, which contains a piperazine compound as an active ingredient. The compound of the present invention can be provided as a novel therapeutic drug for cerebral infarction having an effect of suppressing brain injury volume or improving neurological deficit, since it suppresses production of plural inflammatory cytokines and chemokines present in the brain such as tnf-β, il-1β, il-6 and mcp-1 and the like..
Mitsubishi Tanabe Pharma Corporation
04/16/15
20150104483
 Therapeutic agent for cerebral infarction patent thumbnailnew patent Therapeutic agent for cerebral infarction
The present invention provides a novel therapeutic drug for cerebral infarction, which contains a piperazine compound as an active ingredient. The compound of the present invention can be provided as a novel therapeutic drug for cerebral infarction having an effect of suppressing brain injury volume or improving neurological deficit, since it suppresses production of plural inflammatory cytokines and chemokines present in the brain such as tnf-α, il-1β, il-6 and mcp-1 and the like..
Mitsubishi Tanabe Pharma Corporation
04/16/15
20150104414
 Cytokines and neuroantigens for treatment of immune disorders patent thumbnailnew patent Cytokines and neuroantigens for treatment of immune disorders
The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. Compositions including the same are also provided..
East Carolina University
04/16/15
20150104410
 Serpin fusion polypeptides and methods of use thereof patent thumbnailnew patent Serpin fusion polypeptides and methods of use thereof
This invention relates to molecules, particularly polypeptides, more particularly fusion proteins that include a serpin polypeptide or an amino acid sequence that is derived from a serpin and second polypeptide comprising of at least one the following: an fc polypeptide or an amino acid sequence that is derived from an fc polypeptide; a cytokine targeting polypeptide or a sequence derived from a cytokine targeting polypeptide; a wap domain containing polypeptide or a sequence derived from a wap containing polypeptide; and an albumin polypeptide or an amino acid sequence that is derived from a serum albumin polypeptide. This invention also relates to methods of using such molecules in a variety of therapeutic and diagnostic indications, as well as methods of producing such molecules..
Inhibrx Biopharma Llc
04/16/15
20150103591
 Semiconductor memory with integrated biologic element patent thumbnailnew patent Semiconductor memory with integrated biologic element
A memory includes cytokines, such as macromolecule proteins, as a poly-state data storage. Each fold state of multiple fold states of a protein are associated with a data value.
Toshiba America Electronic Components, Inc.
04/09/15
20150100100
 Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation patent thumbnailInhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist.
04/09/15
20150099652
 In vitro process for the quick determination of a patient's status relating to infection with mycobacterium tuberculosis patent thumbnailIn vitro process for the quick determination of a patient's status relating to infection with mycobacterium tuberculosis
An in-vitro process for the quick determination of the infection status of a mycobacterium tuberculosis infection from whole blood in terms of active or latent tuberculosis, comprising the steps of: stimulating an antigen-specific t cell that is present in a first sample of whole blood with purified protein derivative (ppd) in the presence of antibodies against cd28, or cd28 and cd49d; processing of ppd by antigen-presenting coils (apc) by incubating for 1.5 h to 2.5 h, especially for 2 h, at 35° c. To 39° c., especially at 37° c., optionally with raiding c02; then adding a secretion inhibitor; effecting an intensive mixing; and another incubation for a period of at least 2.5 h at a temperature of from 35° c.
Red Flag Diagnostics Gmbh
04/02/15
20150094285
 Phytochemical compositions including sesamin for anti-inflammatory, anti-cytokine storm, and other uses patent thumbnailPhytochemical compositions including sesamin for anti-inflammatory, anti-cytokine storm, and other uses
A composition (e.g., phytochemical composition) including sesamin, the composition exhibiting anti-inflammatory, anti-cytokine storm, connective tissue preservation, anti-viral, and/or other properties in biological tissue. The phytochemical composition therapeutically affects a pro-inflammatory cytokine condition, for instance facilitating or effectuating decrease in a quantity of a pro-inflammatory cytokine, for example, interleukin-1 and tumor necrosis-alpha.
Chiang Mai University
04/02/15
20150093463
 Nutritional composition containing a peptide component with anti-inflammatory properties and uses thereof patent thumbnailNutritional composition containing a peptide component with anti-inflammatory properties and uses thereof
The present disclosure relates to nutritional compositions comprising a protein equivalent source, wherein 20% to 80% of the protein equivalent source includes a peptide component comprising seq id no 4, seq id no 13, seq id no 17, seq id no 21, seq id no 24, seq id no 30, seq id no 31, seq id no 32, seq id no 51, seq id no 57, seq id no 60, and seq id no 63, and 20% to 80% of the protein equivalent source comprises an intact protein, a partially hydrolyzed protein, or combinations thereof. The disclosure further relates to methods of reducing the inflammatory response and/or production of proinflammatory cytokines, i.e.
Mead Johnson Nutrition Company
03/26/15
20150087818
 Chimeric il-1 receptor type i agonists and antagonists patent thumbnailChimeric il-1 receptor type i agonists and antagonists
Featured herein are non-naturally occuring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor i (il-1ri), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains..
Eleven Biotherapeutics, Inc.
03/26/15
20150087660

Compositions and methods for the treatment of chronic diseases and inflammatory disorders


The invention relates to the compounds of formula i or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i, and methods for the treatment of chronic diseases and inflammatory disorders may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.
03/26/15
20150086583

Mucin-associated surface protein as vaccine against chagas disease


Use of synthetic peptides derived from trypanosoma cruzi antigens and their use in vaccination against trypomastigote infection and chagas disease. T.
Board Of Regents, The University Of Texas System
03/26/15
20150086550

Combination of the application of antibodies for immunostimulation together with glucocorticoids


The present invention relates to methods for reducing or eliminating the non-specific release of a cytokine associated with a disease comprising administering at least one glucocorticoid and an immunostimulating antibody. Additionally, the present invention relates to a pharmaceutical composition that contains at least one immunostimulating antibody and at least one glucocorticoid..
03/26/15
20150086508

Compositions and methods for enhancing epidermal repair and cutaneous innate immunity


The invention disclosed herein relates to the field of epidermal repair and skin innate immunity. More particularly, the invention concerns the use of a mix of cytokines to inhibit keratinocyte differentiation, activate skin innate immunity, increase the expression of anti-microbial peptides, and improve epidermal repair.
03/26/15
20150086480

Heteroaryl inhibitors of pde4


The present invention relates to compounds and methods useful as inhibitors of phosphodiesterase 4 (pde4) for the treatment or prevention of inflammatory diseases and other diseases involving elevated levels of cytokines and proinflammatory mediators.. .
Tetra Discovery Partners, Llc
03/19/15
20150080885

Methods for bilateral renal neuromodulation


Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
Medtronic Ardian Luxembourg S.a.r.l.
03/19/15
20150080884

Methods for monopolar renal neuromodulation


Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
Medtronic Ardian Luxembourg S.a.r.l.
03/19/15
20150080873

Methods for therapeutic renal neuromodulation


Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
Medtronic Ardian Luxembourg S.a.r.l.
03/19/15
20150080481

Methods for renal neuromodulation


Methods and apparatus are provided for treating contrast nephropathy, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers.
03/19/15
20150080419

5-substituted quinazolinone derivatives and compositions comprising and methods of using the same


Provided are 5-substituted quinazolinone compounds, for example, of formula (i), and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use for treating angiogenesis or cytokine related disorders, and pharmaceutical compositions of these compounds are disclosed..
Celgene Corporation
03/19/15
20150079190

Immortalized cell compositions and compositions derived therefrom


The invention is directed to immortalized cell compositions and compositions derived therefrom. The invention is further directed to methods of making and using such immortalized cell compositions and compositions derived therefrom.
Stemnion, Inc.
03/19/15
20150079116

Diagnostic tools for response to 6-thiopurine therapy


Nk cell licensing predisposes patients to chronic inflammatory disease. Methods and kits to diagnose and treat chronic inflammatory disease based on genetic haplotype and cytokine profile are described herein..
The Regents Of The University Of California
03/19/15
20150079048

Method for in vivo, ex vivo and in vitro repair and regeneration of cartilage and collagen and bone remodeling


A method for in vivo, ex vivo and in vitro regeneration of cartilage and collagen. In vivo, ex vivo and in vitro regeneration and de novo formation of articular cartilage and collagen by intermittently applied hydrostatic pressure.
The Board Of Trustees Of The Leland Stanford Junior University
03/19/15
20150079026

Controlled release formulations for the induction and proliferation of blood cells


The absence of regulatory t cells (treg) may underlie disorders including but not limited to autoimmunity, dermatitis, periodontitis and even transplant rejection. Enhancing local numbers of treg through in situ treg expansion or induction is contemplated herein as a treatment option for these disorders.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
03/12/15
20150072889

Systems and methods for detecting infectious diseases


Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (pos) location and may be tested at the pos location for multiple markers for multiple diseases, including upper and lower respiratory diseases.
Theranos, Inc.
03/12/15
20150072338

Systems and methods for detecting infectious diseases


Systems, methods, and devices for detecting infections in a clinical sample are provided. Small-volume clinical samples obtained at a point-of-service (pos) location and may be tested at the pos location for multiple markers for multiple diseases, including upper and lower respiratory diseases.
Theranos, Inc.
03/12/15
20150071967

Tolerisation-inducing composition


The present invention relates to a composition comprising a tolerogenic peptide and a gsk-3 inhibitor and uses thereof. The invention also relates to the use of a gsk-3 inhibitor to accelerate the peptide-mediated shift in secretion profile of lymphocytes from pro-inflammatory to anti-inflammatory cytokines.
University Of Bristol
03/12/15
20150071960

Human inkt cell activation using glycolipids with altered glycosyl groups


Glycosphingolipids (gsls) bearing α-glucose (α-glc) that preferentially stimulate human invariant nkt (inkt) cells are provided. Gsls with α-glucose (α-glc) that exhibit stronger induction in humans (but weaker in mice) of cytokines and chemokines and expansion and/or activation of immune cells than those with α-galactose (α-gal) are disclosed.
Academia Sinica
03/05/15
20150064787

Host cell modification with artificial endosymbionts


The present invention is directed generally to host cells with artificial endosymbionts, wherein the artificial endosymbiont and the host cell communicate with each other to alter a phenotype of the host cell. In some embodiments, the communication comprises the secretion of a polypeptide from the artificial endosymbiont into the host cell.
Bell Biosystems, Inc.
03/05/15
20150064215

Therapeutic delivery and expression system, methods and uses thereof


Therapeutic methods for cancer treatments using a combined prokaryotic-eukaryotic delivery and expression system for the delivery of multiple therapeutic factors via a modified tumor-targeted bacteria. A targeted bacteria-vector system elicits an inter-kingdom dual expression (ikde) of antitumor agents, in the nucleus or cytoplasm of eukaryotic cells, with priming and maintenance of the vector in the bacterium.
The University Of Hong Kong
03/05/15
20150064199

Cancer therapy using beta glucan and antibodies


The present invention relates to methods of using neutral soluble glucan and monoclonal antibodies for antitumor therapy. Neutral soluble beta (1,3; 1,6) glucan (nsg) enhances the tumoricidal activity of the innate immune system by binding to the c3 complement protein receptor cr3.
University Of Louisville Research Foundation, Inc.
03/05/15
20150064179

Humanized anti-il 10 antibodies for the treatment of systemic lupus erythematosus (sle)


Provided is a humanized or chimeric antibody or fragment thereof capable of binding to interleukin-10 (1l-10), wherein said antibody or fragment thereof is capable of being administered to a subject in the absence of an intolerable increase in the level of pro-inflammatory cytokines. Further provided are methods of treatment involving the use of the antibody or fragment thereof..
Biotest Ag
02/26/15
20150057175

Method for monitoring hiv specific t cell responses


The invention relates to a method and a diagnostic kit for monitoring hiv specific t cell responses and identifying subjects capable of controlling hiv progression or preventing hiv infection altogether. The method is based on the combined use of boosted flow cytometry and toggle peptides and can cover a vastly larger set of effector functions than standard assays.
InstituciÓ Catalana De Recerca I Estudis AvanÇats
02/26/15
20150056680

Methods for generating stably linked complexes composed of homodimers, homotetramers or dimers of dimers and uses


The present invention concerns methods and compositions for stably tethered structures of defined compositions, which may have multiple functionalities and/or binding specificities. Particular embodiments concern homodimers comprising monomers that contain a dimerization and docking domain attached to a precursor.
Ibc Pharmaceuticals, Inc.
02/26/15
20150056222

Anti-prlr antibodies and uses thereof


The present invention provides antibodies that bind to prolactin receptor (prlr) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human prlr with high affinity.
Regeneron Pharmaceuticals, Inc.
02/26/15
20150056221

Anti-prlr antibodies and uses thereof


The present invention provides antibodies that bind to prolactin receptor (prlr) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human prlr with high affinity.
Regeneron Pharmaceuticals, Inc.
02/26/15
20150056215

Methods of treating proliferative disorders with malate or derivatives thereof


The present invention relates to methods, compositions, and diagnostic tests for treating and diagnosing proliferative disorders, such as cancel-, that result in dysregulation of malic enzyme 2. In particular, the methods and compositions include monotherapy with malate, or a derivative thereof, as well as combination therapy, such as malate, or a derivative thereof, combined with another therapeutic agent, such as a malic enzyme 2 inhibitor, an antineoplastic agent, a glycolysis inhibitor, an antiangiogenic agent, an immunomodulatory agent, an antibody, or a cytokine..
Beth Israel Deaconess Medical Center, Inc.
02/26/15
20150056160

Chemically induced intracellular hyperthermia


An invention relating to therapeutic pharmacological agents and methods to chemically induce intracellular hyperthermia and/or free radicals for the diagnosis and treatment of infections, malignancy and other medical conditions. The invention relates to a process and composition for the diagnosis or killing of cancer cells and inactivation of susceptible bacterial, parasitic, fungal, and viral pathogens by chemically generating heat, and/or free radicals and/or hyperthermia—inducible immunogenic determinants by using mitochondrial uncoupling agents, especially 2,4 dinitrophenol and, their conjugates, either alone or in combination with other drugs, hormones, cytokines and radiation..
St. Jude Pharmaceuticals, Inc.
02/19/15
20150051441

Embryo implantation


The present invention relates to methods of and compositions comprising cytokines for, improving the success rate of embryo implantation and the success rate of pregnancy rates in females, by providing an immunopermissive uterine environment prior to insemination or implantation of embryos. The methods of the present invention are used to make the uterus more receptive or less hostile to, for example, transferred embryos, sperm or other allografted tissue..
Ostara Biomedical Ltd
02/19/15
20150051156

Method of treating leukemia using rice prolamin


The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (pbmc) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells.
Mackay Memorial Hospital


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Cytokine topics: Antibodies, Inflammation, Specificity, Immunotherapy, Major Histocompatibility Complex, Compatibility, Combination Therapy, Histocompatibility, Immune Response, Monoclonal Antibody, Stimulator, Therapeutics, Immunostimulator, Monoclonal, Proinflammatory

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