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Cytokine

Cytokine-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Inflammation-targeted neutrophil granulocyte drug delivery system and use thereof
China Pharmaceutical University
October 12, 2017 - N°20170292113

Disclosed are an inflammation-targeted neutrophil granulocyte drug delivery system and use thereof, wherein the drug delivery system includes neutrophil granulocytes and a therapeutic substance or a detectable substance loaded into the neutrophil granulocytes or onto the surface of the neutrophil granulocytes in a direct or indirect way. By using the neutrophil granulocytes as a carrier of a drug, the drug ...
Il-17a/f heterologous polypeptides and therapeutic uses thereof
Genentech, Inc.
October 12, 2017 - N°20170291940

The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17f designated herein as interleukin 17a/f (il-17a/f). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, ...
Antibodies specific for il-17a fused to hyaluronan binding peptide tags
Novartis Ag
October 12, 2017 - N°20170291939

The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine il-17a and a peptide tag that binds hyaluronan (ha). The disclosure more specifically relates to specific antibodies and proteins that are il-17a antagonists (inhibit the activities of il-17a and il-17af) and are capable of inhibiting il-17...
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Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
Cedars-sinai Medical Center
October 12, 2017 - N°20170290860

Described herein are compositions and techniques related to generation and therapeutic application of cardiosphere-derived cells (cdcs) and cdc-derived exosomes. These cells and their secreted vesicles contain a unique milieu of biological factors, including cytokines, growth factors, transcription factors, nucleic acids including non-coding nucleic acids such as micrornas, that serve to initiate and promote many therapeutic effects. Exosomes and their ȁ...
Methods of diagnosing proliferative disorders
University Of Central Lancashire
October 05, 2017 - N°20170285030

The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e. G. Gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence ...
Method of treatment using liposomally formulated reduced glutathione to cooperate with il-10 to modulate inflammatory ...
Western University Of Health Sciences
October 05, 2017 - N°20170281714

In the setting of chronic infection with a pathogen, the immune system must adapt to the ongoing presence of inflammatory responses driven by the pathogen in order to control the replication of the infecting agent at an acceptable level while limiting immune-mediated damage (immunopathology) (1). A complex interaction is required to accomplish this using a balance of immune related cytokines to ...
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Cytokine Patent Applications
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  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
Drexel University
September 21, 2017 - N°20170266448

A method of inhibiting the release of a proinflammatory cytokine in a cell is disclosed. The method comprises treating the cell with a cholinergic agonist. The method is useful in patients at risk for, or suffering from, a condition mediated by an inflammatory cytokine cascade, for example endotoxic shock. The cholinergic agonist treatment can be effected by stimulation of an ...
Layer by layer coated mesh for local release of bio-active proteins
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
September 21, 2017 - N°20170266352

The present invention relates to biomaterials coated with an active agent eluting coating, wherein implantation of the coated biomaterial results in reduced implant-related complications and/or improved integration of the biomaterial into the host tissue and further relates to kits containing the coated biomaterial. The present invention also relates to methods and kits for coating the biomaterial. It is based, ...
Fusion proteins containing insulin-like growth factor-1 and epidermal growth factor and variants thereof and uses ...
Igf Oncology, Llc
September 21, 2017 - N°20170266260

Fusion proteins comprising cytokines, particularly insulin-like growth factor-1 (igf-1) and variants thereof, epidermal growth factor (egf), and other ligands to the egf receptor, are provided. The fusion proteins further comprise seq id no:1 or other segments having lysine, glutamic acid, or aspartic acid residues. Uses for the fusion proteins are also provided.
Method and kit for the predictive prognosis of responsiveness to treatments of autoimmune diseases
Universita' Degli Studi Di Roma "la Sapienza"
September 14, 2017 - N°20170261505

The present invention relates to the use of one or more mhc class i molecules dextramers (dextramers®) associated with peptides corresponding to apoptotic epitopes of human cd8+ t cells for the predictive prognosis of responsiveness or non-responsiveness to treatments and/or for monitoring the therapeutic effectiveness of treatments with biological medicaments that block and/or inhibit tnf, and/or ...
Oral administration of an anti-cd20 antibody for treatment of autoimmune disease
Universita' Degli Studi Di Roma "la Sapienza"
September 14, 2017 - N°20170260283

The present invention provides a method for treating or delaying the onset of an autoimmune condition in a human subject. An effective oral dose of an anti-cd20 antibody is administered to the subject. Oral administration of such antibodies as rituximab, ocrelizumab, ofatumumab, obinutuzumab, tositumomab, or ibritumomab are useful in a method of decreasing innate inflammatory cytokines, such as and tnf-a, ...
Polysaccharide composition and use thereof
Infinitus (china) Company Ltd.
September 14, 2017 - N°20170258887

The present invention relates to the field of food or health care product, in particular a polysaccharide composition and use thereof. In the present invention, lentinan, pachymaran and tremellan are compounded. The resultant composition can significantly improve the survival rate and quality of life of mice infected by influenza virus, improve the pulmonary inflammatory lesion degree in mice infected by ...
Viral conjunctivitis treatment using ranpirnase and/or amphinase
Okogen, Inc
September 14, 2017 - N°20170258876

The present specification discloses ranpirnase and amphinase, compositions comprising ranpirnase and/or amphinase, and methods and uses to treat a viral conjunctivitis, an epidemic keratoconjunctivitis, and/or a pharyngoconjunctival fever, reduce or suppress a level of virus or viral titer, reduce or suppress viral replication, reduce or suppress protein synthesis, reduce or suppress a level of a trna, reduce or ...
Cytokine Patent Pack
Download 175+ patent application PDFs
Cytokine Patent Applications
Download 175+ Cytokine-related PDFs
For professional research & prior art discovery
inventor
  • 175+ full patent PDF documents of Cytokine-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Protein-chaperoned t-cell vaccines
Massachusetts Institute Of Technology
September 07, 2017 - N°20170252417

Protein antigens are provided. The protein antigens typically include a peptide antigen conjugated or fused to a chaperone protein to form a “chaperone-antigen” that increases lymph node uptake; improves an immune response; or a combination thereof relative to the peptide antigen alone. The immune response can be, for example, increased antigen-specific proliferation, enhanced cytokine production, stimulation ...
Transdiscal administration of specific inhibitors of pro-inflammatory cytokines
Depuy Synthes Products, Llc
September 07, 2017 - N°20170252375

The present invention relates to injecting a high specificity cytokine antagonist into a diseased intervertebral disc.
Bipartite and tripartite signaling immune cells
Baylor College Of Medicine
August 31, 2017 - N°20170246278

Embodiments of the disclosure include compositions and methods effective for immunotherapy, such as for cancer. The embodiments include cells that recognize a combination of two signals or three signals present at the tumor microenvironment. In certain embodiments, the signals for antigen stimulation, co-stimulation, and cytokine signaling act through separate molecules, although in certain embodiments the signals for antigen stimulation and ...
Innate immune modulating molecule complex for the activation of the innate immune system of aquatic ...
Perkins Biosystems, Llc
August 31, 2017 - N°20170246271

A method for application of an innate immune modulating molecule complex to activate the innate immune system of aquatic animals includes selecting a recombinant dna with characteristics configured for activating aquatic animal macrophages, such as by inducing an innate immune response in the animal. The method for application of an innate immune modulating molecule complex also includes selecting an adjuvant ...
Methods for therapeutic renal neuromodulation
Medtronic Ardian Luxembourg S.a.r.l.
August 31, 2017 - N°20170245926

Methods and apparatus are provided for treating hypertension, e. G., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and ...
Modulating gamma-c-cytokine activity
Bioniz, Llc
August 24, 2017 - N°20170240607

Peptide antagonists of γc-family cytokines, which is associated with important human diseases, such as leukemia, autoimmune diseases, collagen diseases, diabetes mellitus, skin diseases, degenerative neuronal diseases and graft-versus-host disease (gvhd). Thus, inhibitors of γc-cytokine activity are valuable therapeutic and cosmetic agents as well as research tools. Traditional approaches to inhibiting γc-cytokine activity involve raising ...
Anti-cancer agent and cancer cell killing method
Bioniz, Llc
August 24, 2017 - N°20170240581

[solution] an anticancer agent contains a complex produced by making a metal-salen complex compound, which includes a central metal and (n, n, o, o) as a quadridentate ligand and is magnetic, bind to taxane molecules which are anticancerous; and the anticancer agent is to kill cancer cells regarding which phase transition of its cell cycle occurs between phases including gap1, ...
Methods and apparatus for bilateral renal neuromodulation
Medtronic Ardian Luxembourg S.a.r.l.
August 24, 2017 - N°20170239480

Methods and apparatus are provided for bilateral renal neuromodulation, e. G., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation ...
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