|| List of recent Corneal-related patents
| Intrastomal segment|
A description has been provided herein of an intrastromal segment especially designed for use as a prosthesis inside the corneal tunnel of patients suffering from keratoconus. The segment consists of a lengthened body of variable dimensions in the form of an arc with noticeably rounded ends, devoid of any communicating orifice, and endowed with a transverse section that may be triangular, trapezoidal, hexagonal or oval, with at least three marks connecting to the narrowest side for which two ends aid the safe handling of the segment and the mid-section mark serves as a positional reference point.
| Re-treatment for ophthalmic correction of refraction|
A planning device generating control data for a treatment apparatus for refraction-correcting ophthalmic surgery is provided, said apparatus using a laser device to separate a corneal volume, which is to be removed for correction, from the surrounding cornea by at least one cut surface in the cornea of an eye, said planning device comprising an interface for receiving corneal data including information on pre-operative cuts which were generated in a previous ophthalmic operation, and computing means for defining a corneal cut surface which confines the corneal volume to be removed, said computing means defining the corneal cut surface on the basis of the corneal data and generating a control dataset for the corneal cut surface for control of the laser device.. .
| Annular keratopigmentation systems and methods of vision correction of presbyopic eyes|
Systems, devices, and methods for correcting presbyopic vision create a dye ring in the cornea. The intrastromal ring is created using a femtosecond laser and is centered on the visual axis.
| Ocular drug delivery system|
An ocular drug delivery system including a composition in which a formulation having an active agent such as rhgh and or an rhgh mimic, e.g., that increases insulin growth factor (igf) or that alters insulin growth factor binding protein (igfbp) in a subject is dispersed in a pharmaceutical carrier. The composition is configured for placement in, around or on an eye of the subject, and the composition provides controlled release of an amount of the active agent to the eye effective to promote ocular surface and corneal neural regeneration and wound healing..
| Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography|
Ocular surface interferometry (osi) devices, systems, and methods are disclosed for measuring a tear film layer thickness (tflt) of the ocular tear film, including the lipid layer thickness (llt) and/or the aqueous layer thickness (alt). The tflt can be used to diagnose dry eye syndrome (des).
| Lenses, devices, methods and systems for refractive error|
The present disclosure is directed to lenses, devices, methods and/or systems for addressing refractive error. Certain embodiments are directed to changing or controlling the wavefront of the light entering a human eye.
|Method and systems for laser treatment of presbyopia using offset imaging|
An ophthalmic surgery system and method for treating presbyopia by performing ablative photodecomposition of the corneal surface. The offset image of a variable aperture, such as a variable width slit and variable diameter iris diaphragm, is scanned in a preselected pattern to perform ablative sculpting of predetermined portions of a corneal surface.
Provided herein is an endothelial scaffold comprising, consisting of, or consisting essentially of decellularized corneal stroma. In some embodiments, the scaffold has cultured endothelial cells seeded thereon.
|System and method for corneal irradiation|
A device and method for use thereof to illuminate a visual system of a subject includes a light-transforming optical element configured to transform a substantially collimated beam of light into light having a diverging spatial distribution. Optionally, light having such spatial distribution includes a plurality of diverging beams of light.
|Apparatus and method for eye tracking|
A gaze tracking apparatus and method are provided that may calculate a three-dimensional (3d) position of a user using at least two wide angle cameras, may perform panning, tilting, and focusing based on position information of the user and eye region detection information, using a narrow angle camera, may detect pupil center information and corneal reflected light information from an eye image acquired through an operation of the narrow angle camera, and may finally calculate gaze position information from the pupil center information and the corneal reflected light information.. .
|Implantation device for intrastromal prostheses|
A device has been described here which is used as a means of implanting an intrastromal prosthesis, consisting of a segment or ring, on the inside of the patient's corneal tunnel. The implanting device eliminates the need to use conventional forceps and includes for this purpose an injector with a support track for the implant segment, attached to a ring carrier piece coupled to the first end of a cylinder base or tunnel.
|Lipoxin analogs as novel inhibitors of angiogenesis|
The present invention is generally drawn to novel isolated therapeutic agents, termed lipoxins, generated from the interaction between a dietary omega-6 polyunsaturated fatty acid (pufa) such as arachidonic acid (aa), oxygenases and the analgesic aspirin (asa). Surprisingly, careful isolation of compounds generated from the combination of components in an appropriate environment provide di- and tri-hydroxy containing derivatives of aa containing compounds having unique structural and physiological properties.
|Non-contact type tonometer|
A non-contact type tonometer includes: a measurement unit including a first measuring unit for measuring an eye pressure of an examinee's eye in a non-contact manner and a second measuring unit for measuring a corneal thickness of the examinee's eye in a non-contact manner; a moving mechanism for causing relative movement of the measurement unit with respect to the examinee's eye; a drive controller for driving the moving mechanism for aligning the measurement unit; and a setting switch controller for switching an alignment reference on the cornea used for aligning the measurement unit between first and second alignment references. The first alignment reference is a reference for measuring the eye pressure with the first measuring unit and the second alignment reference is a reference for measuring the corneal thickness with the second measuring unit and set closer to a corneal rear surface than the first alignment reference..
|Progressive multifocal rigid gas permeable contact lens|
A contact lens is provided. It is a rigid gas permeable, corneal-scleral progressive, multifocal, vision lens that covers the cornea and a portion of the sclera of an eye.
|Gaze detection apparatus, gaze detection computer program, and display apparatus|
A gaze detection apparatus includes a light source which illuminates a user's eye, an imaging unit which generates an image by capturing the image of a user's face, and a processor adapted to: estimate a distance between the imaging unit and the user's face; calculate the ratio of the distance between the imaging unit and the user's face to a separation distance between the imaging unit and the light source and determine, based on the ratio, whether a bright pupil phenomenon occurs; detect from the captured image a corneal reflection image of the light source and a center of the user's pupil when determining that the bright pupil phenomenon does not occur; and detect the user's gaze direction or gaze position based on a positional relationship between the center of the user's pupil and the corneal reflection image when determining that the bright pupil phenomenon does not occur.. .
|Novel metalloprotein and process for producing same, and prophylactic or therapeutic agent for corneal and conjunctival diseases comprising said metalloprotein|
Selenium-lactoferrin according to the present invention has an excellent therapeutic effect on corneal and conjunctival diseases, and is suitable for mass production on an industrial scale.. .
An auto refracto-keratometer not only produces a black-and-white image for observing the alignment of eyes to be examined using an infrared illumination light but also has a color observation optical system for observing a condition of eyes to be examined using color-illumination light. The auto refracto-keratometer comprises an infrared optical system for examining an alignment and corneal curvature of eyes to be examined; a fogging optical system for relaxing accommodation of the eyes; a measuring optical system for measuring refractive power of the eyes; and a color observation optical system having a visible light source for emitting at least one visible light to the eyes and a 2-dimensional imaging device for detecting image of visible light reflected by the eyes..
|Implantable device for molding the curvature of the cornea|
The present invention relates to an intrastromal corneal device for reshaping the curvature of the cornea comprising a substantially circular structure having a convex surface provided with openings for biological exchange between the layers of the cornea, said substantially circular structure comprising the shape of a circular segment or of a spherical/aspheric cap provided or not with a central opening. Said device further comprises means for promoting the reshaping of the cornea, so that it assumes a curvature closer to the intended curvature, thus providing a significant reduction of visual disturbances caused by corneal ectatic conditions such as keratoconus..
|Biocompatible compositions and methods of manufacture|
This disclosure describes, in one aspect, a method that generally includes combining a silica precursor and a biocompatible polymer under conditions effective for the silica precursor and the biocompatible polymer to form a gel, at least partially dehydrating the gel, and rehydrating the gel. This disclosure also describes a corneal implant prepared by any embodiment of the general method described herein..
|Circular thermal capsulotomy tool and system|
A system and tool for performing a capsulotomy procedure. The system includes a capsulotomy and movement control unit providing electrical current and movement control, and a capsulotomy tool, and an extendable-retractable burning element coupled to the tool, and a slidable shaping element.
|Bicyclic compound and use thereof for medical purposes|
Since a compound represented by the general formula (i) (wherein definition of each group is as described in the specification), a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering activity and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.. .
|Transport of cells in hydrogels|
The present invention relates to hydrogels which may be used to encapsulate or entrap live cells. The invention further relates to methods for transporting live cells which are encapsulated or entrapped within hydrogels from a first location to a second location.
|Systems and methods for corneal cross-linking with pulsed light|
Systems and methods for treating an eye select locations for making incisions in areas of the cornea according to astigmatic keratotomy or radial keratotomy, make incisions in the selected areas of the cornea, apply a cross-linking agent to the selected areas of the cornea, and deliver photoactivating light from a light source to the selected areas of the cornea to initiate cross-linking activity in the selected areas of the cornea.. .
|Method of analyzing image of cell in laminated structure and method of evaluating laminated structure for corneal transplantation|
A method of analyzing an image of a cell in a laminated structure may include the steps of: (a) fluorescently labeling a cell nucleus in the laminated structure having at least one cell layer and one or more other types of biomolecules; (b) acquiring a plurality of planar tomographic fluorescent labeled images in different height directions from the laminated structure for each type of fluorescently labeled biomolecules after the step (a); (c) superimposing a planar tomographic fluorescent labeled image group acquired in the step (b) to construct a three-dimensional tomographic image; (d) dividing the three-dimensional tomographic image constructed in the step (c) into one or two or more cell regions; (e) producing one planar stacked image for each divided cell region after the step (d); and (f) performing image analysis on each planar stacked image produced in the step (e) to analyze cells in the laminated structure.. .
|Novel microfabricated instruments and methods to treat recurrent corneal erosions|
In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the bowman's layer of the eye that are of micro-scale or less.
|Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes|
Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided..
|Gaze detection apparatus and gaze detection method|
A gaze detection apparatus includes: a first imaging unit which has a first angle of view and generates a first image; a second imaging unit which has a second angle of view narrower than the first angle of view, and generates a second image; a face detection unit which detects from the first image a face region; a coordinate conversion unit which identifies on the second image a first region corresponding to the face region or to an eye peripheral region containing the user's eye; a purkinje image detection unit which detects a corneal reflection image of a light source and the center of the user's pupil from within an eye region, identified based on the first region; and a gaze detection unit which detects the user's gaze direction or gaze position based on a positional relationship between the center of the pupil and the corneal reflection image.. .
|Positioning device for eye surgery and procedures|
The invention provides a positioning device for use in an examination, procedure or surgery of the eye. The positioning device includes an incurvate body with an upper peripheral edge having a first arc length, a lower peripheral edge having a second arc length, and a curved lateral portion therebetween.
|Method for measuring an eye|
A method for measuring the axial length of an eye using optical coherence tomography, during which a plurality of a-scans of the oct measurement are combined to an axial length, taking into account the alignment with which they were obtained, and taking into account the topography of the cornea. The distance of the front of the cornea from the retina is determined using oct while measuring or controlling the alignment of the measuring device to the eye in that the topography of the front of the cornea is measured or made available.
|Method and device for high-resolution retinal imaging|
The invention relates, according to one aspect, to a retinal imaging device including at least one source (lsa, lsr) for emitting a light beam in order to illuminate the retina of an eye (10) of a subject, a retinal imaging path including a detection device (12) having a detection plane (121) and an optical imaging system (l1, l5, l6), an analysis path including a device (15) for measuring optical defects having an analysis plane (151) for receiving a set of light rays backscattered by the retina and optical means for adjoining said analysis plane and a predetermined plane in the input space of said imaging system of the imaging path, a correction device (14) shared by said analysis and imaging paths, which includes a correction plane (141) and which is intended to correct, in said correction plane, the light rays from said emission source and backscattered by the retina according to the optical defects measured by the device for measuring optical defects. The retinal imaging device further includes a light blackout system (20), which is positioned in an adjacent plane or which coincides with said correction plane, or which is positioned in an image plane of said correction plane located on an optical path shared by the analysis and imaging paths, and which is sized so as to at least partially black out the reflections of the light rays from said emission source by the corneal surface..
|Corneal stromal mapping|
A method of measurement is presented. A method of measurement according to some embodiments of the present invention includes obtaining a first measurement from a first imaging method; obtaining a second measurement from a second imaging method; combining the first and the second measurement to obtain a structural information and an image representation of a structure of an eye; calculating at least one shape parameter from the structural information; and displaying the image representation of the structure of the eye..
|Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations|
The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye.
|Ocular collar stent for treating narrowing of the irideocorneal angle|
An ocular stent for insertion in an anterior chamber of an eye is provided. The stent facilitates the restoration of the structure of an irideocorneal angle of the anterior chamber for treating structural changes from ocular aging.
|Combined wavefront and topography systems and methods|
Methods, software, and systems are provided for determining an ablation target shape for a treatment for an eye of a patient. Techniques include determining wavefront information from the eye of the patient with a wavefront eye refractometer, determining anterior corneal shape information from the eye with a corneal topography device, and combining the wavefront information and the anterior corneal shape information to determine the ablation target shape..
|Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion|
An ophthalmic solution is provided. The ophthalmic solution is hypertonic.
|Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion|
An ophthalmic solution is provided. The ophthalmic solution is hypertonic.
|High-strength collagen fiber membrane and a manufacturing method thereof|
The object of the present invention is to provide a collagen fiber membrane, which has sufficient strength and can be used as a cell culture substrate, a scaffold material for regenerative medicine (for example, material for tissue engineering of cartilage, bone, ligament, corneal stroma, skin, or liver), an implantation material (for example, wound dressing material, bone grafting material, hemostatic material, anti-adhesive material) or a carrier for drug delivery. The object of the present invention can be solved by a fish-derived collagen fiber membrane, characterized in that (1) a tensile strength is 30 mpa or more, (2) a density determined by the gravimetric method, is 0.4 g/cm3 or more, and (3) an average membrane thickness is 1 μm to 2 mm, and a variation in membrane thickness is plus or minus 30%, relative to the average membrane thickness..
|Line-of-sight direction determination device and line-of-sight direction determination method|
A line-of-sight direction determination device includes: a line-symmetric position determiner that determines that the corneal reflection image of a left eye or a right eye is located at a line-symmetric position with respect to the center line of the pupils of the left and right eyes; and a line-of-sight direction determiner that determines, from the line-symmetric position determination result, a line-of-sight direction at a specific position including the installation position of an imaging unit or an irradiation unit at the substantially same position as the imaging unit. The line-of-sight direction determination device determines that the corneal reflection image is line symmetric and, from this line symmetry property, determines a specific line-of-sight direction..
|Tps tools and methods for the surgical placement of intraocular implants|
Provided herein are alignment systems, computer-implemented systems and methods utilizing the same for planning an optimal surgical implantation of asymmetric optics into one or both eyes of a patient and/or correcting astigmatism thereof. The methods generally comprise obtaining reference data comprising the surgical procedure plan, the reference image and the corneal topographic measurements for the patient's eye, determining an optimal placement angle of an optical zone on the cornea from the reference data and placing the asymmetric optic into the eye to match the determined optimal placement angle.
|Ophthalmological device and method for the treatment of corneal diseases|
An ophthalmological device (10) for the treatment of corneal diseases such as keratocanus and glaucoma, comprises a moulding head (12), a suction body (14) and a uv lamp (15). The moulding head (12) has a hollow cylindrical configuration and includes a rigid moulding lens (18) for shaping the cornea of an eye (11) of a patient.
|Inversion marking for contact lenses|
An ophthalmic lens incorporating clearly identifiable, highly visible inversion marking(s) that become invisible when placed on the eye may be utilized to allow an individual to easily distinguish between the normal state of the lens and the inverted state of the lens. The ophthalmic lens comprises a thin material layer capable of changing its optical state from diffusive light scattering, colored, or both, to invisible transparent at the corneal temperature of a normal person, at the influence of ambient light, or a combination thereof..
|Composition for a topical ophthalmic clear colloidal liquid which undergoes a liquid-gel phase transition in the eye|
The present invention is directed to a topical ophthalmic composition for a liquid comprised of clear colloidal polar nanolipids delivered in submicron sized particles, aqueous colloidal lubricants, aqueous polymers, emulsifies, and a unique stabilizing buffer system, which undergoes a liquid-gel phase transition in the eye. Said composition is designed to deliver advanced eye lubricants, protect the three (3) layers of corneal film from dryness, and provide a unique system of dry eye treatment that addresses and treats all three layers of corneal tear film.
|Methods and apparatus to identify eye coverings for vision|
Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering.
|Eye therapy system|
Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure.
|Eye therapy system|
Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes.
|Extended wear ophthalmic lens|
A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods.
|Therapeutic agent for corneal sensory nerve damage containing semaphorin inhibitor as active ingredient|
Wherein r1 represents a hydrogen atom or a carboxyl group, r2 represents a hydrogen atom or a hydroxy group, r3 represents a hydrogen atom or a carboxyl group, and r4 represents a hydrogen atom or a hydroxy group.. .
|Corneal endothelial cell photographing apparatus|
A corneal endothelial cell photographing apparatus for photographing an endothelial cell in the cornea of the examinee's eye includes an optical system, an image processor, and a display controller. The optical system includes an illuminating optical system for irradiating the cornea with illuminating light, and a light receiving optical system including a light detector and configured to receive reflected light from the cornea including the endothelial cell.
|Blade for preparing an endothelial graft, and associated preparation method|
The invention relates to an instrument for preparing an corneal endothelial graft, the tool being a trephine blade (1) having a cross section in the form of an arc of a circle of between 270° and 355°. The invention also relates to a method of preparing a graft using such an instrument..
|Multifocal ophthalmic lens|
A method of designing a multifocal ophthalmic lens with one base focus and at least one additional focus, capable of reducing aberrations of the eye for at least one of the foci after its implantation, comprising the steps of: (i) characterizing at least one corneal surface as a mathematical model; (ii) calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model; (iii) modelling the multifocal ophthalmic lens such that a wavefront arriving from an optical system comprising said lens and said at least one corneal surface obtains reduced aberrations for at least one of the foci. There is also disclosed a method of selecting a multifocal intraocular lens, a method of designing a multifocal ophthalmic lens based on corneal data from a group of patients, and a multifocal ophthalmic lens..
|Corneal contact system|
An interface device for selectively engaging a suction ring with a patient interface of a laser unit includes an annular shaped base member that is formed with an orifice. The suction ring is affixed against one side of the base member to surround the orifice.
|Intracorneal drug delivery device and associated methods|
Methods and devices for delivering an active agent into the eye of a subject are provided. In one aspect, an ocular device for delivering an active agent through a cornea of an eye of a subject can include a housing configured to couple to the eye of the subject and a corneal seal coupled to the housing and positioned in the housing to encircle the cornea during use to form a corneal region.
|Non-fibrogenesis collagen material and a manufacturing method thereof|
The object of the present invention is to provide a non-fibrogenesis collagen material which has a sufficient strength and can be used as a cell culture substrate, a scaffold material for regenerative medicine (for example, material for tissue engineering of cartilage, bone, ligament, corneal stroma, skin, or liver), an implantation material (for example, wound dressing material, bone grafting material, hemostatic material, anti-adhesive material) or a carrier for drug delivery. The object of the present invention can be solved by a non-fibrogenesis collagen material characterized by comprising a fish-derived collagen..
|Method for making self-assembling, collagen-based material for corneal replacement|
A material derived from sea cucumber collagen fibrils is suitable for use in corneal replacements or as an implantable contact lens. To produce material, the collagen fibrils are centrifuged into orthogonal stacks of lamellae comprised of aligned fibrils.
|Integrated surgical microscope and wavefront sensor|
A wavefront sensor is integrated with a surgical microscope for allowing a doctor to make repeated wavefront measurements of a patient's eye while the patient remains on an operating table in the surgical position. The device includes a wavefront sensor optically aligned with a surgical microscope such that their fields of view at least partially overlap.
|Apparatus for assistance in the implantation of a corneal prosthesis in a human eye and method for executing such an implantation|
Proposed is an apparatus for assistance in the implantation of a corneal prosthesis in a human eye. The apparatus comprises a laser device for providing focussed, pulsed laser radiation, and a control program for the laser device.
|Pressurization optimization f0r corneal graft preparation|
Described herein are methods for accurate and precise preparation of corneal grafts. The utilization of pressure optimization in preparing corneal grafts allows for increased accuracy in regards to the residual posterior bed.
In a contactless tonometer having a mechanism of puffing compressed air by moving a piston in a cylinder, puffing of unnecessary air against the eye to be inspected is suppressed. An apparatus includes a corneal shape changing unit configured to change a shape of a cornea of an eye to be inspected by compressing air in a cylinder by using a piston, and puffing the compressed air from the nozzle to the cornea, a piston control unit configured to control operation of the piston, and an intraocular pressure measurement unit configured to measure an intraocular pressure of the eye by detecting a state of a changed shape of the cornea.
|Ocular drug delivery system|
An ocular drug delivery system can include a composition in which a formulation including recombinant human growth hormone (rhgh) is contained in a polymer matrix. The composition is configured for placement in or on the eye of a subject, and provides controlled release of an amount of the rhgh to the eye effective to promote healing of a conjunctival, sclera and or corneal wound..
|Method for treating filtration failure after trabeculectomy surgery|
The current invention relates to the improvement of trabeculectomy surgery. The improvement more specifically resides in an extended lifetime of the sclera-corneal drainage channel created by trabeculectomy surgery.
|Method for detecting point of gaze and device for detecting point of gaze|
A gaze point detection device 1 has four cameras 2a, 2b, 2c, 2d, light sources 3a, 3b, 3c, 3d, control circuits 4, 5, 6, and an image processor 7. The image processor 7 calculates vectors r, each of which is from a corneal reflection point to the center of a pupil, on a plane that is vertical to base lines.
|Device and process for machining the cornea of a human eye with focused pulsed laser radiation|
A device for machining the cornea of a human eye with focused pulsed laser radiation includes controllable components, a control computer for controlling these components and a control program for the control computer. The control program contains instructions that are designed to generate an incision figure in the cornea permitting the insertion of an intrastromal corneal ring implant.
|Bicyclic compound and use thereof for medical purposes|
Wherein definition of each group is as described in the specification, or a salt thereof, a solvate thereof, or a prodrug thereof has strong and sustaining intraocular pressure lowering action and, further, has no side effect on eyes such as ocular stimulating property (hyperemia, corneal clouding etc.), aqueous humor protein rise etc., it has high safety, and can be an excellent agent for preventing and/or treating glaucoma etc.. .