|| List of recent Corn-related patents
|Novel methods and devices for the therapeutic treatment of myopia|
Non-surgical therapeutic methods and devices for the treatment of myopia are presented. The eyeball of a patient suffering from myopia is elongated causing refracted light to fall onto a spot in-front of the retina.
|Device and process for surgery on the human eye|
A laser apparatus is controlled by a control program that operates to use laser radiation to generate an incision figure in the cornea of an eye, the incision figure including a an incision that bounds a corneal tissue volume. The control program operates to move the radiation focus in a radiation propogation direction successively in a plurality of superposed planes such that the radiation focus is moved without motion control in the propogation direction.
|Microprotrusion member retainer for impact applicator|
A retainer (34) is provided for holding a microprotrusion member (44) for application of the microprotrusion member (44) to the stratum corneum with an impact applicator (10). The microprotrusion member (44) includes a plurality of microprotrusions (90) which penetrate the stratum corneum to improve transport of an agent across the stratum corneum..
|Apparatus, interface unit, suction ring and method to monitor corneal tissue|
An apparatus and a method for cutting or ablating corneal tissue of an eye provide for detection of electromagnetic radiation exiting the eye. A detector is provided and coupled to a computer controlling the cutting or ablating laser radiation so that a two- or three-dimensional image of radiation exiting the eye can be generated..
|Eye covering and refractive correction methods and apparatus having improved tear flow, comfort, and/or applicability|
An eye covering such as a contact lens may comprise one or more structures to pump tear liquid under the covering such that the covering can remain in the eye and correct vision for an extended amount of time. In many embodiments, the covering comprises a material having fenestrations to draw tear liquid under the covering and an outer portion shaped to contact the conjunctiva over the sclera, such that when the eye closes pressure of one or more eyelids urges tear liquid through one or more fenestrations and under the outer portion shaped to contact the conjunctiva.
|Model newborn human eye and face manikin|
A model newborn human eye which includes a hemispherical-shaped, integrally molded top assembly comprising a visually transparent cornea portion surrounding a visually opaque sclera portion in combination with a hemispherical-shaped bottom assembly comprising a bowl-shaped substrate disposed therein. The model newborn human eye further comprises a retinal layer comprising a two dimensional image of retinal vasculature disposed on said substrate, where the model newborn human eye is dimensioned for diagnosing retinopathy of prematurity (“rop”) in premature infants..
|Frontal view reconstruction for iris recognition|
Iris recognition can be accomplished for a wide variety of eye images by correcting input images with an off-angle gaze. A variety of techniques, from limbus modeling, corneal refraction modeling, optical flows, and genetic algorithms can be used.
|Method and apparatus for determining the location of the ocular pivot point|
The invention relates to a method for determining the location of the ocular pivot point (adl) in an eye (10) of a test person. In the method, the mean curvature (kh) of the cornea (14) of the eye (10) is determined.
|Gaze tracking with projector|
The invention is directed to systems, methods and computer program products for gaze tracking. An exemplary method includes directing light into an eye using a projector; detecting, using an image-capturing module, a reflection from a surface associated with the eye; and determining a line of sight associated with the eye based on the detected reflection.
|Contactless photodisruptive laser cataract surgery|
Method, apparatus and systems for laser surgery as part of cataract surgery. The implementation thereof includes: a means to perform incisions in the cornea and inside the eye.
The present invention relates to a topical gel composition comprising ingenol-3-angelate, wherein the composition provides greater flux, according to the in vitro diffusion test, of ingenol-3-angelate into the stratum corneum, epidermis and dermis after application of the gel composition to skin than does a reference gel of ingenol-3-angelate, namely the picato® product.. .
|Urea-silicone gel for hyperkeratosis treatment|
Compositions and methods for urea silicone gels for treating hyperkeratotic skin diseases that may benefit from barrier protection and from urea silicone gel's ability to return water balance to the skin are disclosed. Skin conditions that may be treated with urea silicone gels may be excessive dryness, callus, corns, old and new scars, and keloids, among others.
|Methods of blocking ultraviolet radiation and promoting skin growth using terpenes and terpenoids|
The present invention provides methods of treating humans and animals with terpenes and terpenoids in order to rejuvenate the skin and increase the protective layer against irradiation by ultraviolet radiation (uvr). More specifically it provides terpenes and terpenoids as ingredients that work as persistent uvr blockers.
|Systems, methods, and compositions for cross-linking|
Various agents and additives for cross-linking treatments are identified in disclosed studies. The characteristics of the various agents and additives may be advantageously employed in formulations applied in cross-linking treatments of the eye.
|Pharmaceutical containing ppar-delta agonist|
A preparation containing [3-[2-[4-isopropyl-2-(4-trifluoromethyl)phenyl-5-thiazolyl]ethyl]-5-methyl-1,2-benzisoxazol-6-yl]oxyacetic acid, [4-[3-[2-(4-trifluoromethyl)phenyl-4-isopropyl-5-thiazolyl]propionyl]-2-methylphenoxy]acetic acid or [4-[3-[2-(2-hydroxy-4-chlorophenyl)-5-isopropyl-4-oxazolyl]propionyl]-2-methylphenoxy]acetic acid, or a pharmacologically acceptable salt thereof as an active ingredient is used as an agent for promoting proliferation of meibomian gland epithelial cells or corneal epithelial cells, as well as a therapeutic agent for ocular diseases such as meibomian gland dysfunction, dry eye and the like.. .
|Method for assessing perspiration reduction|
A method to assess perspiration reduction of a composition comprising obtaining an amount of water in stratum corneum in a first area of skin on an individual using confocal raman spectroscopy, applying a composition to the first area of skin on the individual, having the individual perform an activity to cause the individual to perspire, and obtaining an amount of water in stratum corneum in the first area of skin on the individual after the activity using confocal raman spectroscopy.. .
|Preoperative toric axis corneal marker|
Preoperative toric axis corneal marker useful for delimiting the correct position of an intraocular lens, implanting an intraestromal ring in a patient's eye, performing a limbal relaxing incision or any other type of intervention requiring a precise marking prior to an intervention on the cornea, wherein the marker incorporates an attaching means to a slit lamp and which marker comprises a generally “l”-shaped body which is anchored, by means of a first wing, to the attaching means to the slit lamp and its second wing features a hollow cylindrical shape where a tubular bushing, which presents at least a small lug radially arranged at its free base, is fitted, through which the marking on the eye will be accomplished.. .
|Low hydrous soft ophthalmic lens and method for manufacturing the same|
Provided are a low hydrous soft ophthalmic lens that can remarkably reduce or avoid a phenomenon in which a lens sticks to a cornea when worn and can reduce a decrease in the performance of a coating layer when rubbing the low hydrous soft ophthalmic lens for cleaning and a method for manufacturing the same. The low hydrous soft ophthalmic lens has a layer formed of a hydrophilic polymer on at least part of the surface of a base material containing a polysiloxane compound, and at least part of the inside of the layer is cross-linked..
|Implanting oversized objects into surgical beds|
The present invention relates to a deformable object to be implanted into a surgical site (exemplified by but not limited to a cornea lenticule, e.g., that could be native corneal tissue or a synthetic or biosynthetic construct), surgical instrumentation for altering the curvature and arc length of the deformable object to be implanted (e.g. Corneal lenticule), as well as methods for introduction of the deformable object into the specifically prepared wound bed and for introduction of the deformable object..
|Apparatus and method for corneal marking|
A corneal marking system and methods for its use, has a first tilt-detecting device attached to a corneal marker, adapted to produce a signal when the corneal marker is in a horizontal position. In another version, the first tilt-detecting device is adapted to produce a signal when the corneal marker is in tilted to a pre-selected value and a second tilt-detecting device is attached to the patient's head to measure the tilt of the head and is adapted to produce a signal when the head is tilted to match the pre-selected value of the first tilt-detecting device.
|Adaptive patient interface|
A patient interface for an ophthalmic system can include an attachment module, attachable to the ophthalmic system, and a contact module, configured to accommodate a viscoelastic substance between the patient interface and a procedure eye. The viscoelastic substance can include a fluid, a liquid, a gel, a cream, an artificial tear, a film, an elastic material, or a viscous material.
Provided is a non-contact tonometer capable of inhibiting unnecessary air discharge against an eye to be inspected. The non-contact tonometer includes: a corneal shape deforming unit for pressurizing air in a cylinder using a piston provided in the cylinder and puffing the air through an opening in the cylinder toward a cornea of an eye to be inspected so as to deform the cornea; a piston control unit for controlling operation of the piston; and an eye pressure measurement unit for detecting a state of deformation of the cornea so as to measure an eye pressure of the eye to be inspected.
|Method for automatic optimization of the calculation of an intraocular lens to be implanted|
A method for calculating the values of an intraocular lens to be implanted, wherein the results of numerous cataract operations are taken into account in the calculation for intraocular lenses to be implanted in the future. At least the corneal topography, the length of the eye and the depth of the anterior chamber are determined pre-operatively, the values of the iol to be implanted are calculated by means of ray-tracing, and at least the corneal topography, the length of the eye, the depth of the anterior chamber and the objective, wavefront-based residual refraction are determined post-operatively.
|Real-time surgical reference indicium apparatus and methods for astigmatism correction|
A system, method, and apparatus for generating at least one user adjustable, accurate, real-time, virtual surgical reference indicium including data for making at least one limbal and/or corneal relaxing incision for use in astigmatism correcting procedures are disclosed. An example method includes providing at least one real-time multidimensional visualization of at least a portion of an eye to a surgeon and producing at least one rotationally accurate virtual indicium including data for making at least one limbal relaxing incision, at least one corneal relaxing incision or a combination thereof on the eye in conjunction with the real-time multidimensional visualization of at least a portion of the eye..
|System and methods for determining tissue elasticity|
The present disclosed subject matter is directed to medical devices and methods that assist in non-invasively determining elastic properties (e.g., elasticity, viscosity, etc.) of superficial tissues, especially superficial corneal tissues such as the epithelium and stroma, using acoustic energy.. .
|Tonometer calibration tool|
A tool for calibrating a non-contact tonometer (nct) comprises a body having a mating feature configured for removably mounting the body on the nosepiece or on the measurement head of the nct, a pressure sensor carried by the body and arranged to receive an air pulse discharged by the nct to provide a pressure signal in response to the air pulse, and a radiation emitter carried by the body, wherein the radiation emitter provides a pseudo-applanation event when the pressure signal reaches a predetermined level that is detectable by the nct as though an actual corneal applanation had taken place. In one embodiment, the mating feature includes a mounting orifice for receiving a portion of the nosepiece.
|Therapies for disorders of the cornea and conjunctiva|
Unexpectedly, disorders of the cornea and conjunctiva are found to be caused or to be exacerbated, at least in part, by extracellular atp and p2x7 receptor activation. Therapeutic compositions for topical administration to the eye for the treatment of disorders of the cornea and conjunctiva include an entity that inhibits p2x7 receptor function, reduces the effective concentration of extracellular atp, or both..
|Design of myopia control ophthalmic lenses|
Lenses are designed using the corneal topography or wavefront measurements of the eye derived by subtracting the optical power of the eye after orthokeratology treatment from the optical power before orthokeratology treatment.. .
An interconnectable furniture having a planar surface. The planar surface includes at least one convex side that is convex with respect to points within the planar surface, and at least one concave side that is concave with respect to points within the planar surface.
The invention relates to a medical device, including interchangeable parts thereof, for performing corneal cell freezing wherein said device comprises an elongate member having a flow line system through which a cryogenic fluid flows to cool a cryoprobe tip which tip is fixed and comprises a concave epithelial surface contact member.. .
|Eyesight correction apparatus and method for controlling same|
The eyesight correction apparatus according to the present invention comprises: a cutting unit for cutting out a portion of the cornea such that a stromal bed and a flap are arranged; an image processing unit for collecting, in images, the state between the flap which is located on the stromal bed and processing the images; a beam generating unit for generating a joining beam for interconnecting between the flap and a cut area of the cornea on the basis of the image signal processed by the image processing unit; a beam delivery unit for guiding the joining beam along the cut area between the flap and the cornea; and a control unit for controlling an operation of the beam delivery unit such that the joining beam can be radiated along the cut area between the flap and the cornea on the basis of the image signal.. .
|Methods and systems for tracking a torsional orientation and position of an eye|
Methods and systems for tracking a position and torsional orientation of a patient's eye. In one embodiment, the present invention provides methods and software for registering a first image of an eye with a second image of an eye.
In a non-contact tonometer, puffing of air unnecessary for measurement of an eye to be inspected after driving of a solenoid is stopped is suppressed. In the non-contact tonometer including a corneal shape change unit configured to change the shape of the cornea by pressurizing and supplying a gas in a cylinder by a piston, and an eye pressure measuring unit configured to measure the eye pressure from the state of the shape change of the cornea, an opening portion configured to be formed in the outer wall of the cylinder and decide the internal volume of the cylinder when pressurizing the gas, and a pressurized gas volume change unit configured to change a position where the opening portion can connect the inside of the cylinder with the outside, and change the internal volume of the cylinder when pressurizing the gas..
|Non-contact tonometer, control method of the same, and program|
An excessive amount of pressurized air is inhibited from being blown to an eye of a patient during measurement of a corneal shape deformation amount. In a non-contact tonometer having a piston, a driving unit to drive the piston, a fluid election unit to blow air pressurized by driving the piston toward a cornea of an eye to be inspected, and an interocular pressure measuring unit to detect a deformed state of the cornea and measure an interocular pressure, there are provided a piston displacement restricting unit that restricts a displacement amount when the piston pressurizes the air, and a changing unit to change the displacement amount to be restricted by the piston displacement restricting unit..
|Apparatus for electrodermal activity measurement with current compensation|
An apparatus for measuring electrodermal activity can include a first electrode in contact with a first portion and a second electrode in contact with a second portion of a stratum corneum, and in electronic communication with the second electrode through the stratum corneum. A processing module is electrically coupled to the first electrode and the second electrode and is operable to (a) bias the first electrode at a first voltage v+ and the second electrode at a second voltage v− (b) measure a current flowing between the first electrode and the second electrode, the current corresponding to the conductance of the stratum corneum, (c) subtract a compensation current from the measured current (d) measure a resulting current producing an amplified output voltage (e) measure a conductance of the stratum corneum, and (f) adjust at least one of the first voltage, the second voltage and the compensation current to desaturate the output voltage..
|Method for producing corneal endothelial cell|
The invention provides a method of efficiently producing corneal endothelial cells, particularly from corneal stroma or ips cell-derived neural crest stem cells, a method of producing corneal endothelial cells stably in a large amount by inducing more efficient differentiation of stem cells into corneal endothelial cells, and a medicament containing corneal endothelial cells. The method of inducing differentiation of stem cells into corneal endothelial cells includes a step of culturing the stem cells in a differentiation induction medium containing a gsk3 inhibitor (preferably a gsk3β inhibitor) and retinoic acid, with the differentiation induction medium preferably further containing one or more of tgfb2, insulin, a rock inhibitor, and the like..
|Microfluidic chips for acquiring sperms with high motility, productions and applications thereof|
This invention relates to microfluidic chips for and their applications in acquiring sperms with high velocity and/or motility. The microfluidic chip comprises an inlet region, a first flow channel, a divergent channel, an optional block structure with rounded corners and one or more outlet region(s).
|Endothelial cell culture|
The disclosure relates to cell culture vessels comprising fabricated cell culture surfaces providing means for efficient corneal endothelial cell growth and the use of the cultured cells in the repair of corneal tissue damage.. .
|Ophthalmic device, control method, and non-transitory computer readable medium|
Provisioned is a selecting unit configured to select a bright spot image corresponding to a reflected light beam reflected by the cornea of the subject eye from among a plurality of bright spot images on the basis of a positional relationship between a first bright spot image formed from a plurality of bright spot images corresponding to a first light beam in a first direction and a second bright spot image corresponding to a second light beam in a second direction different than the first direction, and a calculating unit configured to calculate a state of alignment between the subject eye and a measuring unit using the bright spot image selected from the first bright spot images.. .
An ophthalmic apparatus for guiding positioning an intraocular lens for astigmatism correction, includes: an obtaining unit for obtaining an anterior segment image of a patient's eye and an astigmatic axis of a patient's cornea; a feature point designating unit for defining a feature point of an iris or a sclera on the anterior segment image; and a display control unit for superimposing and displaying a gauge image that models a cornea gauge and an axis that represents the astigmatic axis of the cornea on the anterior segment image.. .
An intraocular lens in which deterioration in contrast is suppressed even when the optical axis of the intraocular lens is decentred from the optical axis of the eyeball when the intraocular lens is inserted into the eye while the advantage of a conventional aberration reduction type intraocular lens that the image is seen clearly is sustained by employing such a power distribution as respectively having at least one positive power deviation region (e1) having a power larger than that represented by the reference power distribution and at least one negative power deviation region (e2) having a power smaller than that represented by the reference power distribution in the central region of the intraocular lens assuming that a power distribution being set to cancel the spherical aberration of cornea when the intraocular lens is inserted into the eye is the reference power distribution.. .
|Yeast expressing saccharolytic enzymes for consolidated bioprocessing using starch and cellulose|
The present invention is directed to a yeast strain, or strains, secreting a full suite, or any subset of that full suite, of enzymes to hydrolyze corn starch, corn fiber, lignocellulose, (including enzymes that hydrolyze linkages in cellulose, hemicellulose, and between lignin and carbohydrates) and to utilize pentose sugars (xylose and arabinose). The invention is also directed to the set of proteins that are well expressed in yeast for each category of enzymatic activity.
|Contact lens for vitreoretinal surgery|
A contact lens assembly has a central lens and a circumscribing flange, the lens having an eye contact surface shaped generally to a radius of curvature of a cornea of an eye. The flange comprises a sterile sponge-like liquid absorbent flexible material having a central aperture for fitting snugly about an outer circumference of the lens and extending radially outward therefrom.
|Ophthalmologic apparatus, method for controlling ophthalmologic apparatus, and program|
An ophthalmologic apparatus is configured to determine a direction in which a target that is used to adjust a working distance comes into focus based on an influence of astigmatism contained in a cornea reflection image of an eye to be examined.. .
|Ophthalmic observation apparatus and method of using the same|
An ophthalmic observation apparatus includes an illumination light supplier which supplies illumination light, of substantially parallel light rays, toward an examinee's eye including an eyeground and an anterior chamber angle, an imager which captures an image of the eye which is illuminated by the illumination light, a rotary driver which rotates the illumination light supplier and the imager about a specified center, a cornea curvature measurer which measures a curvature of a cornea of the examinee's eye, and a controller which sets a curvature center of the cornea as the specified center based on the measured curvature of the cornea. The controller drives the rotary driver to rotate the illumination light supplier and the imager about the specified rotational center and controls the imager to capture an image of the eyeground and the anterior chamber angle illuminated by the illumination light..
|Exfoliating head for a personal care appliance|
Exfoliating heads with an abrasive surface are disclosed for use with a personal care appliance. The personal care appliance is configured to oscillate the exfoliating head to provide improved smoothing and exfoliation of a subject's epidermis with or without the antecedent application of skin care formula.
|Solar collector comprising an opaque cover|
A solar collector has an opaque cover heated by solar energy. Heat flows from the opaque cover by conduction, convection, and infrared emittance across a gap within an at least substantially airtight enclosure to an absorber containing a working fluid.
|Diapers, diaper wipes and diaper pads with active ingredients integrated therein|
A diaper, diaper sheet insert and/or a diaper wipe sheet with active ingredients integrated therein, including ointments for treating diaper rash, baby oils and lotions for treating dry skin, and/or powder treatments for absorbing moisture, including baby powder, corn starch powders and the like. In a first embodiment, the invention provides a diaper having active ingredients integrated therein comprising a skin-contact surface, at least one inner absorption layer, an outer most layer, and a barrier wall having an active ingredients segment and preventing contact of the active ingredients with the diaper's skin-contact surface.
|Cross-linking composition delivered by iontophoresis, useful for the treatment of keratoconus|
An improved formulation of an ophthalmic composition contains riboflavin, as cross-linking agent of corneal collagen, administered by corneal iontophoresis, able to guarantee an increased capacity of permeation of riboflavin of the corneal stroma and therefore greater therapeutic efficacy in the treatment of keratoconus.. .