|| List of recent Corn-related patents
| Method of accelerating corneal wound healing|
The topical ophthalmic use of 5,6,7-trihydroxyheptanoic acid and analogs for the acceleration of corneal wound healing in humans, is disclosed.. .
| Inhibitor for corneal epithelial cell death, inhibitor characterized by combining hyaluronic acid and flavin adenine dinucleotide|
A combination of hyaluronic acid or a salt thereof and flavin adenine dinucleotide or a salt thereof can be an inhibitor for corneal epithelial cell death induced by ultraviolet irradiation and/or dryness because it significantly inhibits the decline of the number of living cells in corneal epithelial cells induced by ultraviolet irradiation or dryness.. .
| Single step liquefaction and saccharification of corn starch using an acidophilic, calcium independent and hyperthermophilic pullulanase|
Moreover, recombinant tk-pul can be used for single step liquefaction and saccharification of corn starch (without any α-amylase or β-amylase) at ph 4.2 in the absence of calcium.. .
| Skin permeating and cell entering (space) peptides and methods of use therefor|
Compositions that facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (sc) and/or the cellular membranes of viable cells are provided. In some embodiments, the compositions include a peptide, an active agent, and a carrier that includes the active agent, wherein the peptide has an amino acid sequence set forth in any of seq id nos: 1-18; the peptide is associated with and/or conjugated to the active agent, the carrier, or both; the carrier is selected from the group consisting of a micelle, a liposome, an ethosome, and combinations thereof; and the composition is capable of penetrating a stratum corneum (sc) layer when contacted therewith or penetrating a cell when contacted therewith, and optionally wherein the composition further includes one or more free peptides having an amino acid sequence set forth in any of seq id nos: 1-18.
|Device and method to assist treatment of the cornea|
A method and device for assisting treatment of the cornea, the device including a memory (4), an interface (8) capable of receiving and supplying data, a processing unit (6) for calculating and supplying to the interface (8) an ophthalmological value for use in the treatment of the cornea, a scheduler (10) which configured, upon receipt of initial central keratometric index (kc) data and initial asphericity value (qi) data at the interface (8), to store those data in the memory (4), to call the processing unit (6) with the initial central keratometric index (kc) and initial asphericity value (qi) data as well as with target asphericity value (qv) data in order to calculate a peripheral keratometric index (kp), to store the corresponding data in the memory (4) and to supply them to the interface (8).. .
|Eye drop formulation with enhanced properties by combining sodium hyaluronate with carboxymethylcellulose|
Embodiments described herein relate to formulations for and methods of use for eye drop formulations comprising carboxymethyl cellulose (cmc) and hyaluronic acid (ha) with an improved distribution on the cornea during blinking.. .
|Skin rejuvenation cream|
This invention is based upon the discovery that a mixture of ethyl lactate and isoamyl lactate can be used to improve the penetration of active ingredients in skin care formulations through the outer layers of the stratum corneum and viable epidermis and into the dermis layer of the skin structure. The present invention more specifically discloses a method of rejuvenating skin affected by intrinsic aging and/or photo-induced aging comprising topically applying a topical formulation to the skin, wherein said topical formulation is comprised of ascorbic acid, an amino acid selected from the group consisting of phenylalanine and tyrosine, a non-toxic zinc salt, carnosic acid, α-tocopherol, 0.01 weight percent to 20 weight percent of a mixture of ethyl lactate and isoamyl lactate, wherein the weight ratio of the ethyl lactate to the isoamyl lactate is within the range of 1:10 to 20:1, and a pharmaceutically acceptable carrier..
|Personal care compositions containing volumizing, fixative, and conditioning particles for fine hair|
The present invention is directed to a personal care composition comprising: a personal care composition comprising a particle complex consisting of a hydrolyzed corn starch, a starch/cellulose polymer, a hydrogenated phospholipid, and gum arabic; and an aqueous carrier. The personal care composition is suitable for delivery as a sprayable composition which provides volumizing, hair fixing, and conditioning as a leave-on treatment.
|Ectocornea-like sheet and method of constructing the same|
It is intended to provide a transplantation material applicable to ocular surface diseases with a need for ectocornea transplantation (i.e., an ectocornea-like sheet). Oral mucosal epithelial cells are inoculated onto an amnion and then cultured in the coexistence of supporter cells.
|Method for forming volumizing, fixative, and conditioning particles for fine hair|
A method for forming a large particle complex comprising the steps of combining a hydrolyzed corn starch polymer, a starch/cellulose polymer, a hydrogenated phospholipid, and gum arabic in a cosmetically acceptable carrier to form a premix composition; heating said premix to about 85° c. For about 15 minutes; and cooling the composition to room temperature.
|Bi-radial patient interface|
To improve the precision of ophthalmic surgical procedures by reducing corneal wrinkling, a patient interface for an ophthalmic system can include an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system; a contact portion, configured to dock the patient interface to an eye; and a contact element, coupled to the contact portion, configured to contact a surface of a cornea of the eye as part of the docking of the patient interface to the eye, and having a central portion with a central radius of curvature rc and a peripheral portion with a peripheral radius of curvature rp, wherein rc is smaller than rp.. .
|Corneal stiffening for treating astigmatism|
Methods are provided for treating astigmatism in an eye of a patient. An axis of greater curvature of the eye is determined.
|Compositions and methods for treating injuries to the visual system of a human|
Methods and compositions for treating injuries to the neural system of a human eye and corresponding structures in the brain are designed to degrade gylcosaminoglycans (gags) within chondroitin sulphate proteoglycans (cspg) using chondroitinase abc (cabc), preserving neural architecture and protecting the visual system from progressive damage after vascular insult of the optic nerve and/or other portions of the visual system. The methods include delivering the cabc composition by topically applying the composition onto the patient's cornea, stereotactic injections into the related anatomy, delivery by micro-osmotic pumps, delivery by nanoparticles and/or nanocapsules, and delivery through intravitreal implants..
|Blender with varying internally and externally shaped container|
A blender includes a container having a plurality of ribs projecting into a processing zone of the container. The plurality of spaced ribs each include a width and a depth that taper from a top end section adjacent a teardrop shaped opening of the container to a more narrow bottom end section adjacent a bottom wall of the container.
|Double function tilting head ophthalmic instrument|
Systems for performing sequential multiple function ophthalmic measurements using separate measurement instruments, by mechanical switching between the instruments. In prior art systems, the separate measurement instruments are stacked, and transfer between them is performed by means of a linear mechanical motion stage.
|Capsulotomy device with suction cup compression chamber|
A surgical device and procedure are provided for smoothly and easily accessing tissue to perform microsurgery, including a capsulotomy of a lens capsule of an eye. The device includes a handpiece with a tip for insertion into an incision in the cornea of the eye.
|Microstructure device with removable microstructure patch|
A device and method for creating microchannels in the stratum corneum. The device includes a handle and a substrate detachably attached to the handle by a coupler.
|Antigen binding constructs|
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain fc region of an antibody, wherein each epitope binding domain in capable of binding to vegf, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with vegf signalling, such as diabetic macular edema (dme), wet age-related macular degeneration (wet amd). Diabetic retinopathy, retinal vein occlusion (rvo), and corneal neovascularisation, and polynucleotide sequences encoding said antigen binding constructs..
|Compositions derived from stem cell released molecules & methods for formulation thereof|
Compositions for use in treatment of a variety of tissue diseases include stem cells and stem cell released molecules (srm's) suspended in an aqueous solution with a cellulosic material or other thickening agent. The stem cells and srm's can be derived from one or more distinct cell lines.
|Systems using eye mounted displays|
A display device is mounted on and/or inside the eye. The eye mounted display contains multiple sub-displays, each of which projects light to different retinal positions within a portion of the retina corresponding to the sub-display.
|Enameled flat wire|
There is provided an enameled flat wire, in which a flat wire conductor having a rectangular cross section composed of four flat surfaces and four rounded corners has an enamel coating with a predetermined thickness for electrical insulation. In the enameled flat wire, a difference in a thickness of the enamel coating on the flat surfaces between a maximum thickness and a minimum thickness is equal to or less than 25% of the predetermined thickness..
|Anterior corneal shapes and methods of providing the shapes|
Methods of determining a desired shape for the anterior surface of the cornea in vision correction procedures.. .
|Inbred corn line i9545|
An inbred corn line designated i9545 is disclosed. The invention relates to the plants and seeds of inbred corn line i9545 and methods for producing a corn plant produced by crossing the inbred corn line i9545 with itself or with another corn plant.
|Ophthalmic treatment device, system, and method of use|
Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye).
A biscuit structure contains a body formed in a circular column shape or a flatly elongated block shape, and a mixing ingredient of the body includes corns, rice, brown rice, egg yolk powders, sugars, salts, palm oil, soy flour (mixed from soybeans, wheat, salts and sugars), and maltodextrin. The body is molded and baked, and then a sticky ingredient is applied on the body, thereafter a crushed nut ingredient is sprayed on the sticky ingredient of the body.
|Silk compositions and methods of using same|
The present invention provides for silk-derived compositions for treating a wide variety of ocular conditions. The composition is produced by processing the silk cocoon into a water-based solution (i.e., a dissolved silk), which is then cast into a film.
|Biometric authentication using the eye|
An apparatus and method for authenticating a subject using the eye as an identifying biometric, in particular the shape of the cornea. An image projection device generates and projects an image of a pattern, of plural discrete points, onto at least a part of the cornea of the eye.
|Sensor system for determining the control signals activating ciliary muscles|
In a sensor system for determining the control signal supplied to the ciliary muscles of an eye for adjusting the focal length of the lens of an eye, a contact element of an electrically non-conductive material and provided with sensors is disposed on the cornea of the eye so that the sensors are arranged in contact with an annular area of the cornea next to the ciliary eye muscles so as to be able to sense the focal adjustment signals supplied to the ciliary muscles and the sensed adjustment signals are supplied to a signal processing unit which provides a control signal to a lens system with adjustable focal length for adjusting the focal length thereof depending on the focal adjustment signals of the ciliary eye muscles.. .
|Ocular pressure regulation|
Disclosed are devices and methods of treating an ocular disorder including forming a self-sealing incision in a cornea into an anterior chamber of an eye; introducing through the incision a fluid drainage tube having a distal end, a proximal end and a longitudinal, internal lumen extending through the fluid drainage tube, wherein at least the proximal end passes through the anterior chamber; and implanting the distal end of the fluid drainage tube in fluid communication with the suprachoroidal space such that the proximal end of the fluid drainage tube remains in fluid communication with the anterior chamber.. .
|Method and a device for monitoring pupil|
The invention provides a method of monitoring the pupil of a subject, wherein a sensor for observing the pupil is arranged between the cornea and the eyelid covering the cornea, the sensor is powered through the eyelid, and the pupil-observation signals delivered by the sensor are collected through the eyelid.. .
|Hay-based logs and method of making the same|
A hay-based log formed of a combination of pieces of hay and a binding agent. The hay pieces and the binding agent are compressed together into a solid shape.
|Ophthalmological laser method and apparatus|
The present invention relates to a femtosecond laser ophthalmological apparatus and method that creates a flap on the cornea for lasik refractive surgery or for other applications that require removal of corneal and lens tissue at specific locations such as in corneal transplants, stromal tunnels, corneal lenticular extraction and cataract surgery. The femtosecond laser is transferred to a hand piece module via a rotating mirror arm module.
This invention relates to antiviral agents, in particular to salts useful in the treatment of infections caused by picornaviridae, such as human rhinovirus (hrv) and methods for their preparation. The invention also relates to the use of these salts in the treatment of picornavirus infections.
|Ophthalmic aberrometer capable of subjective refraction|
The present invention contemplates an ophthalmic aberrometer combining measurements of wavefront aberrations and subjective refraction into a single instrument and refers both measurements to the same corneal plane the present invention also contemplates an ophthalmic aberrometer employing an open field and subjective correction to overcome instrument myopia and to ensure accurate measurement of the best-corrected visual acuity in addition to measurement of wavefront aberrations. The present invention further contemplates an ophthalmic aberrometer implementing an optical relay with adjustable optical power compensation to eliminate the need for flipping plurality sets of trial lenses for defocus correction.
|Shape memory polymer intraocular lenses|
A shape memory polymer (smp) intraocular lens may have a refractive index above 1.45, a tg between 10° c. And 60° c., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum.
|Corneal multi-plane incision using a surgical laser setup calculations interface|
An apparatus and a method are described for setting up a medical laser machine configured to be used in eye surgery for making a multi-planar incision. In various embodiments, a software interface is provided to receive, from a user, one or more dimensional measurements of an eye of a patient as input, automatically calculate precise geometric and other setup parameters, based on a set of equations, of a multi-planar incision for the patient's eye, and provide the calculated parameters to the user for setting up the medical laser machine to make the incision..
|Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes|
Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided..
|Method for preparing corneal endothelial cell|
The present invention relates to a method for preparing corneal endothelial progenitor cells by adherent culturing a cell population isolated from corneal endothelial cell tissue at a low density by using a serum-free medium. The present invention also relates to a method for preparing corneal endothelial cells by differentiation-inducing the corneal endothelial progenitor cells obtained by the aforementioned method.
|Renewable diesel and jet fuel from microbial sources|
The invention provides methods of manufacturing alkanes from triglyceride oils produced through fermentation of oil-bearing microbes. The processes provided herein can utilize a variety of carbohydrate feedstocks including cane bagasse, sugar beet pulp, corn stover, glycerol, corn starch, sorghum, molasses, waste glycerol, and other renewable materials.
|Large diopter range real time sequential wavefront sensor|
Example embodiments of a large dynamic range sequential wavefront sensor for vision correction or assessment procedures are disclosed. An example embodiment optically relays a wavefront from an eye pupil or corneal plane to a wavefront sampling plane in such a manner that somewhere in the relaying process, the wavefront beam from the eye within a large eye diopter range is made to reside within a desired physical dimension over a certain axial distance range in a wavefront image space and/or a fourier transform space.
|Control element for a vehicle seat|
A control element for a vehicle seat includes a bladder configured to be filled with a pressure medium and which includes first and second films connected together along a connecting seam to form a bladder chamber. The connecting seam may have a shape of a polygon, e.g., a square or rectangle, with rounded corners, wherein the sides connecting the corners are curved in a concave manner toward the interior of the polygon.
|Compensation systems and methods for flap induced aberrations|
Embodiments of the present invention encompass systems and methods for customized vision treatments that account for effects associated with corneal flap creation.. .
|System and method for monitoring change of intraocular pressure and contact lens for sensing change of intraocular pressure|
A system and a method for monitoring change of intraocular pressure and a contact lens for sensing change of intraocular pressure are provided. The contact lens includes a first material layer and a first pattern.
|Skin permeating and cell entering (space) peptides and methods of use thereof|
The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (sc) and/or the cellular membranes of viable cells.. .
|Crosslinker enhanced repair of connective tissues|
A protein crosslinker delivery device includes a body and a protein crosslinker held in a synthetic or natural biodegradable polymer. The body, a coating on the body, or an attachment to the body can contain the protein crosslinker holding biodegradable polymer.
|After-treatment of refraction correction by ophthalmic surgery|
A planning system for generating control data, a treatment device for ophthalmic surgery to correct refraction, and a method for generating control data for such a treatment device, by which method it is easily possible to continue an interrupted treatment or correct a previous treatment. To this end, the planning system has calculating means for defining a corneal incision surface, wherein the calculating means determine the new corneal incision surface such that the existing corneal incision surface is incised by at least a part of the new corneal incision surface at an angle of between 60° and 120°..
|Laser system and method for correction of induced astigmatism|
There is provided a system, apparatus and methods for developing laser systems that can create precise predetermined clear corneal incisions that are capable of reducing induced astigmatism. The systems, apparatus and methods further provide laser systems that can provide these incisions at or below bowman's membrane..
|High-order optical correction during corneal laser surgery|
Systems and methods related to corneal ablation for treatment of one or more high-order optical aberrations are provided. A method includes providing a defect-correcting prescription, determining an ablation profile to impose the prescription on the cornea, and determining a sequence of laser-energy ablations to impose the ablation profile on the cornea.
|Method for preparing corneal donor tissue for refractive eye surgery utilizing the femtosecond laser|
A method of accurately fabricating a non-human donor corneal tissue for implantation into a recipient human cornea, the method comprising the steps of: removing corneal tissue from a donor with a femtosecond laser; placing the corneal tissue in a fixative solution for a selected time interval to cross-link the collagen fibrils in the tissue and prevent swelling of the corneal tissue; and shaping the tissue to provide a conical inlay of a selected shape and thickness having one or more radial extensions. The method is such that the corneal inlay may be attached to the peripheral corneal and/or the sclera.
|Shielded intraocular probe for improved illumination or therapeutic application of light|
An intraocular light probe has a mask or shield affixed at its distal end thereof which forms a directed light beam for intraocular application of light to target tissues or intraocular application of therapeutic light. The mask or shield serves to more fully focus, intensify and direct the beam toward the target tissues.
|Eye coverings for corneal healing and methods of use|
Methods for providing faster visual and functional recovery of patients following ocular therapy such as ocular therapy involving manipulation of the ocular tissue and/or associated with a lesion external to the optical region and ocular therapy involving incising the ocular tissue and implanting a device within the optical region are disclosed. Methods of healing a trauma wound to a cornea and methods of protecting an eye of a patient from potential injury are also disclosed.