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 Corneal dynamic model algorithm and system using the same patent thumbnailCorneal dynamic model algorithm and system using the same
A corneal dynamic model algorithm and system using the same is provided, comprising an ophthalmotonometer and a calculating unit. The calculating unit comprises the algorithm for calculating the corneal dynamic model.
National Taiwan University


 Methods of reducing corneal endothelial cell loss patent thumbnailMethods of reducing corneal endothelial cell loss
Provided herein are methods of reducing corneal endothelial cell loss (e.g., nerve loss-related corneal endothelial cell loss) that include selecting a subject identified as having an eye with reduced numbers of corneal nerves as compared to a reference eye, e.g., an eye of a healthy control, and administering vasoactive intestinal peptide (vip) or a nucleic acid encoding vip to the selected subject.. .
Schepens Eye Research Institute


 Method and  inserting an implant in the cornea of the eye patent thumbnailMethod and inserting an implant in the cornea of the eye
Methods, devices, and systems for inserting an implant in the cornea (105) of the eye, where the implant is a microshunt device (405,515). The microshunt device may comprise an inlet (425) section comprising at least one lumen and at least one inlet opening; an outlet (420) section comprising at least one lumen that connects to at least one outlet opening; and where the microshunt device (405,515) is configured to be implanted within the cornea (105) of an eye, where the microshunt device effects the flow of aqueous humor from an anterior chamber (160,235) of the eye to the anterior surface of the cornea (410,630), bypassing the trabecular meshwork (145,240), thereby diverting aqueous humor from the anterior chamber (160,235) to the surface of the cornea (410,630)..

 Applicator for superficial corneal medicaments patent thumbnailApplicator for superficial corneal medicaments
An applicator for applying fluid medicaments to a corneal surface of a patient, after surgery, includes a circular, ring-shaped member. The ring member creates an aperture which extends between parallel planes, with a wall surrounding the aperture as well as upper and lower openings into the aperture.

 Instrument for unrolling corneal tissue in descemet's membrane endothelial keratoplasty surgery patent thumbnailInstrument for unrolling corneal tissue in descemet's membrane endothelial keratoplasty surgery
A surgical instrument to be used in an corneal transplant surgical procedure known in the art as descemet's membrane endothelial keratoplasty (dmek). Specifically, the instrument disclosed herein (nhl, neusidl-hannush loop), is designed for the portion of the dmek procedure where upon the transplantation of a very thin layer of endothelial cells and their basement membrane (dmek graft), the transplanted material must be flattened.

 Technique for centering an application field patent thumbnailTechnique for centering an application field
The present disclosure generally relates to a technique for centering an application field for an ophthalmic device or a method. More specifically, and without limitation, the disclosure relates to a device and a method for centering an application field relative to the cornea of a human eye responsive to movement of the eye tracked in real-time during the ophthalmic application based on a pupil center.
Wavelight Gmbh


 Tear shaping for refractive correction patent thumbnailTear shaping for refractive correction
A lens for refractive tear shaping, having a curved lens body with a peripheral edge and a central opening therein. The central opening is shaped and sized and has a tear shaping edge structured to form a tear meniscus within the central opening.

 Orthokeratology lens with displaced shaping zone patent thumbnailOrthokeratology lens with displaced shaping zone
A contact lens for application in practice of orthokeratology on an eye, including a curved shell having a concave surface and a convex surface. The concave surface includes a carrier zone and a back shaping zone, the back shaping zone having a first curvature and the carrier zone having at least one second curvature.

 Corneal endothelial cell marker patent thumbnailCorneal endothelial cell marker
The purpose of the present invention is to provide a method of purification and preparation of cultured corneal endothelial cells, and in particular, to provide cell surface markers for use in corneal endothelial cells not including transformed cells. Provided are cell markers for distinguishing normal cells and transformed cells, in particular normal and transformed corneal endothelium cells.
Senju Pharmaceutical Co., Ltd.


 Ionic liquids for transdermal drug delivery patent thumbnailIonic liquids for transdermal drug delivery
The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered.
Los Alamos National Security, Llc


Nipple shield


A shield for a post-operative reconstructed nipple is disclosed. The shield includes a vertical shield portion and a flat base with rounded corners and symmetric suture holes.

Introducing bubbles to improve cornea reshaping without the creation of a flap


Ultra-short pulsed laser radiation is applied to a patient's eye to create a row of bubbles oriented perpendicular to the axis of vision. The row of bubbles leads to a region of the eye to be ablated.
The Trustees Of Princeton University


Contact lens with a microfluidic channel to monitor radius of curvature of cornea


A contact lens that monitors the radius of curvature of cornea includes an amplification chamber, am annular membrane, a microfluidic channel, and a gas reservoir within a top and bottom lens layers of the contact lens. The annular membrane is positioned within the amplification chamber and is in fluid communication with the gas reservoir through the microfluidic channel.

Eye gaze detection supporting device and eye gaze detection supporting method


An eye gaze detection supporting device includes an illuminator including a light source that performs irradiation with light, a plurality of imaging units, position detectors that detect a first position indicating a center of a pupil and a second position indicating a center of corneal reflection, from an image of an eye ball of a subject irradiated with light by the illuminator, and captured by the imaging units, and a calculator that calculates a fourth position indicating a curvature center of a cornea, based on a position of the light source, a third position on a display, the first position, and the second position.. .
Jvc Kenwood Corporation


Corneal cover and use thereof


A corneal cover for placement on a patient's eye during eye surgery. A generally concave central arcuate portion has a first radius of curvature.

Scraping device


A scraping device includes a first grip with a first scraping member connected thereto. A connection member is connected to the first scraping member.

Method of producing dual-textured frozen food products


A method for producing dual-textured frozen food products allows for the quick preparation of snack-sized frozen food products that maintain a crunchy exterior when heated for consumption within a microwave or an oven. The method uses increased total frying steps to fully fry the food product prior to freezing and packaging steps.
Frito-lay North America, Inc.


Method of producing dual-textured frozen food products and products made therefrom


A method for producing dual-textured frozen food products allows for the quick preparation of snack-sized frozen food products that maintain a crunchy exterior when heated for consumption within a microwave or an oven. The method uses increased total frying steps to fully fry the food product prior to freezing and packaging steps.
Frito-lay North America, Inc.


Method for culture of corneal endothelial cells, process for production of corneal endothelial cell sheet for transplantation purposes, and culture kit for corneal endothelial cells


The invention provides a method of culturing a corneal endothelial cell by use of a culture medium containing an ascorbic acid derivative and the like.. .
Cornea Regeneration Institute Co., Ltd.


Methods and systems for material transport across an impermeable or semi-permeable membrane via artificially created microchannels


Systems and methods are disclosed for transporting a transport target across a membrane that is impermeable or semi-permeable to the transport target via artificially created microchannels or through hypodermic microneedles. The transport target can be a medicant and the membrane can be a stratum corneum layer of skin.
Guided Therapy Systems, Llc


Shape memory polymer intraocular lenses


A shape memory polymer (smp) intraocular lens may have a refractive index above 1.45, a tg between 10° c. And 60° c., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum.
Abbott Medical Optics Inc.


Intraocular lenses


A shape memory polymer (smp) intraocular lens may have a refractive index above 1.45, a tg between 10° c. And 60° c., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum.
The Regents Of The University Of Colorado


Shape memory polymer intraocular lenses


A shape memory polymer (smp) intraocular lens may have a refractive index above 1.45, a tg between 10° c. And 60° c., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum.
The Regents Of The University Of Colorado


Shape memory polymer intraocular lenses


A shape memory polymer (smp) intraocular lens may have a refractive index above 1.45, a tg between 10° c. And 60° c., inclusive, de minimis or an absence of glistening, and substantially 100% transmissivity of light in the visible spectrum.
The Regents Of The University Of Colorado


Intraocular pressure detecting device


The present invention provides an intraocular pressure detecting device, which includes: a sampling device, a comparison device and a detecting device. The sampling device includes an opening window, an imaging unit and a puffing unit.
Crystalvue Medical Corporation


Presbyopia correction through negative spherical aberration


Devices, systems, and methods for treating and/or determining appropriate prescriptions for one or both eyes of a patient are particularly well-suited for addressing presbyopia, often in combination with concurrent treatments of other vision defects. High-order spherical aberration may be imposed in one or both of a patient's eyes, often as a controlled amount of negative spherical aberration extending across a pupil.
Amo Manufacturing Usa, Llc


Method for preparing heterogenetic corneal material


Disclosed is a method for preparing a heterogenous corneal material, wherein during the whole preparation process, different concentrations of glycerol are used to achieve that the heterogenous corneal graft has the transparent, properties of no viruses and cells; resistance to degradation and immunogenicity of collagen can be further reduced by collagen cross-linking; and under the whole eye saving, cross-linkers 1-(3-dimethylaminopropyl)-3-ethylcarbodi imide (edc) and n-hydroxy sulfosuccinimide (nhs) are used for cross-linking, thus enabling the form thereof to be closer to that of a fresh cornea and improving biomechanical properties thereof. The method can prepare a heterogenous corneal material with a high transparency, a low immunogenicity and a good bioactivity and biocompatibility, and can maintain that the three-dimensional structure of collagen is close to that of a fresh cornea.
Youvision Biotech Co., Ltd.


Regenerative prostheses as alternatives to donor corneas for transplantation


The present invention relates to a corneal implant comprising a matrix material and a core part wherein the core part is arranged essentially in the middle of the matrix material. The core part is anti fouling in order to stop cell proliferation across said part.
Uab Ferentis


Method of treating a malignancy in a subject and a pharmaceutical composition for use in same


There is a disclosed a method of killing abnormal cells such as malignant cells including melanoma cells, using a virus recognising at least one of a cell adhesion molecule and a complement regulatory protein. The virus may be a member of the picornaviridae family.
Viralytics Limited


Systems and methods for femtosecond laser photorefractive keratectomy


Embodiments of this invention generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for photorefractive keratectomy. In an embodiment, an ophthalmic surgical laser system comprises a laser source generating a pulsed laser beam and a laser delivery system delivering the pulsed laser beam to a cornea of an eye.
Amo Development, Llc


Patient interface for ophthalmologic diagnostic and interventional procedures


Configurations are described for conducting ophthalmic procedures to address cataract-related clinical challenges. In one embodiment, a one-piece patient contact interface may be utilized to couple a diagnostic and/or interventional system to a cornea of a patient; in another embodiment, a two-part configuration may be utilized; in another embodiment, a liquid interface two-part embodiment may be utilized..
Optimedica Corporation


Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography


Ocular surface interferometry (osi) devices, systems, and methods are disclosed for measuring a tear film layer thickness (tflt) of the ocular tear film, including the lipid layer thickness (llt) and/or the aqueous layer thickness (alt). The tflt can be used to diagnose dry eye syndrome (des).
Tearscience Inc.


Corneal young's modulus algorithm and system using the same


A corneal young's modulus algorithm and system using the same is provided, comprising a tonometer and a computation unit. The computation unit comprises an algorithm for calculating young's modulus.
National Taiwan University


Mold, imprint apparatus, and manufacturing article


A mold includes a pattern portion in which a pattern is formed, and a concave portion formed in the back surface of the pattern portion and having a size to include the pattern portion in a planar view. The edge of the pattern portion has an almost rectangular shape in the planar view.
Canon Kabushiki Kaisha


Method for treating itch


The present invention is anti-itching powder that blocks transmission to stratum corneum and invasion up to epidermal cells by emulsion as a result of further concentration on skin stratum corneum. The emulsion is produced by mixing sweat continuously secreted during rest and sebum.
Lilac Laboratory Co., Ltd.


Eye drop formulation with enhanced properties by combining sodium hyaluronate with carboxymethylcellulose


Embodiments described herein relate to formulations for and methods of use for eye drop formulations comprising carboxymethyl cellulose (cmc) and hyaluronic acid (ha) with an improved distribution on the cornea during blinking.. .
Allergan, Inc.


Ophthalmic tool for eye imaging device


An ophthalmic tool includes an ophthalmic speculum for holding a patient's eye open and for guiding a lens probe of an eye imaging device to be directly contacted with a cornea of the patient's eye. The ophthalmic speculum includes two eyelid distensible frames, a mechanism to spread the eyelid distensible frames apart, and a probe guiding frame including a plurality of probe guiders spacedly extended from the eyelid distensible frames.

Corneal stromal keratocyte culture


The present invention relates to corneal stromal keratocytes (csks) culture. In particular the present invention relates to a method for culturing corneal stromal keratocytes ex vivo.
Singapore Health Services Pte Ltd


Method for preparing a fibrillar collagen matrix


The present invention relates to a method for preparing a fibrillar collagen matrix, which is advantageously transparent or composite, suitable for being used as a biomaterial, in particular as a corneal substitute.. .
Université Pierre Et Marie Curie


Closed-loop laser eye surgery treatment


A laser eye surgery system includes a laser to generate a laser beam. A topography measurement system measures corneal topography.
Optimedica Corporation


Apparatus, system, and intraocular lens power calculation using a regression formula incorporating corneal spherical aberration


Optical power=constant1*(biometric parameter)+constant0*(corneal spherical aberration). Constant1 and constant0 comprise an empirically derived factor across other eyes.

Fuel rod cladding, fuel rod and fuel assembly


The invention relates to the field of nuclear engineering and can be used in the manufacture of fuel rods and fuel assemblies for heavy liquid metal cooled reactors, and also in the manufacture of fuel rod simulators for use in irradiation devices designed to test the operability of real fuel assemblies. The present gadding of a fuel rod for a heavy liquid metal cooled reactor is in the form of a weldless tubular element h helically-coiled fins disposed on the outer surface of said element, which is made from a ferritic-martensitic chromium-silicon steel with a minimum ferrite grain size of 7 on the gost 5639 scale, wherein each fin has an opening angle of from 22 to 40 (preferably from 30 to 40) and the cross-section of the fin is in the shape of a trapezoid with rounded corners at the top of the trapezoid and smooth corners at the base of the trapezoid.
Joint Stock Company "akme-engineering"


Contact lenses having a reinforcing scaffold


Ophthalmic lenses for correcting refractive error of an eye are disclosed. Ophthalmic lenses include an inner optic portion having a scaffold between an anterior portion and a posterior portion.
Nexisvision, Inc.


Methods for treating ophthalmic disorders, diseases and injuries


The invention is directed to methods for treating ophthalmic disorders, diseases and injuries. In particular, the invention is directed to treating disorders, diseases and injuries of the cornea and ocular surface.
Noveome Biotherapeutics, Inc.


Amniotic or placental preparation and device for ophthalmic use as a dressing to enhance healing


A biodegradable lens-shaped patch useful for healing and treatment of ocular conditions is disclosed. The patch is formed from a biodegradable carrier which carries amniotic extract and/or placental extract.

Optical instrument for biomechanical diagnosis of eye disease


A method and system for performing biomechanical diagnosis of eye disease may include a brillouin light source to generate a brillouin sample beam, and a second harmonic generation (shg) light source to generate an shg sample beam. Both the brillouin sample beam and the shg sample beam may be coincidentally directed to a biological tissue sample in a confocal manner to a focus position.
Wavelight Gmbh


Ophthalmological device


An ophthalmological device calculates a cornea surface shape of an eye to be examined. The ophthalmological device includes a ring image photographic optical system configured to radiate a plurality of concentric ring light to the cornea surface of the eye and take reflected images of the plurality of ring light reflected from the cornea surface of the eye, an interference optical system configured to radiate measurement light to the eye and detect interfering light composed of reflected light of the measurement light reflected from the eye and predetermined reference light.
Tomey Corporation


Leavened chew bone for pets and preparing the same


A leavened chew bone for pets and a method for preparing the leavened chew bone use wheat gluten, corn starch, and chicken or/and beef as main materials. The method involves steps of (1) dissolving, (2) activating yeast powder, (3) mixing, (4) slurry making, (5) fermenting and toughening, (6) forming, (7) leavening, and (8) heat-drying.
Wenzhou Yuxiang Pet Product Co., Ltd.


Stalk cutter device and use


The stalk cutter device and method of use thereof obtains a desired length of plant stalk, particularly a cornstalk, from a desired distance from the ground. The stalk cutter device includes a pair of handles pivotally connected to a pair of pruning type of cutters.
Board Of Trustees Of The University Of Arkansas


Fan tray perforation pattern


An apparatus is provided in one example embodiment and includes a plate having a plurality of perforations configured in a pattern. The pattern includes the plurality of perforations arranged in concentric circles centered at a point.
Cisco Technology, Inc.


Support structure for power electronics


The application concerns a support structure for power electronics, comprising a holder for the insertion of at least one power electronics module and an electrically conductive external geometry which surrounds the holder and has rounded corners and edges with a radius of curvature which is greater than a predetermined minimum radius.. .
Abb Technology Ag


Method and device for providing a touch-based user interface


A device for providing a touch-based user interface is disclosed. The device comprises a screen, a camera, and processor.
Telefonaktiebolaget L M Ericsson (publ)


Contact lens and method and systems for constructing a contact lens


Contact lenses, methods and systems for accomplishing the requirement for biocompatibility of oxygen delivery to the eye, and the cornea in particular, when elements and components are used which reduce the transmissibility of oxygen and which require coverage of a significant area of the non-vascularized cornea. A contact lens assembly is provided, comprising: an anterior surface, a posterior surface and at least one element or component having a substantially low oxygen permeability disposed within the lens.
Innovega, Inc.


Triangular-shaped plunger head and toilet plunger having the same


A triangular-shaped plunger head has a construction to make a sealing contact with a triangular-shaped toilet drain hole. The plunger head includes a triangular-shaped bottom wall and a triangular-shaped bottom edge that has three rounded corners and three straight sides, one side extending between a different pair of rounded corners.

Methods of modulating lymphangiogenesis, e.g., to treat corneal transplant rejection, in a subject


Methods of modulating the occurrence of lymphangiogenesis in a subject are provided. In some instances, the method includes reducing antigen presenting cell function, such as cell trafficking to draining lymph nodes.
The Regents Of The University Of California


Pharmaceutical composition for preventing or treating ocular surface disease


A pharmaceutical composition for preventing or treating an ocular surface disease is disclosed, wherein the pharmaceutical composition includes, as an active component, collagen type ii α1 based peptide gqdglagpk isolated from chondrocyte-derived extracellular matrix (cdem). In an alkaline burn animal mode treated with peptide gqdglagpk, the occurrence of corneal opacification is reduced as well as the expression of angiogenic factors (e.g., cd31 and vegf).
Inje University Industry-academic Cooperation Foundation


Device for laser treatment of a human eye


An apparatus for treatment of an eye comprises a source of pulsed laser radiation, and a control device for controlling a focus of the laser radiation to generate an incision figure. The incision figure defines a corneal flap, a first auxiliary channel and a second auxiliary channel.
Wavelight Gmbh


Temporary seat cover apparatus


A seat back cover in the form of a flexible bag of plastic or paper is shaped to fit over the back of a typical folding chair. The seat back cover may include structure to retain the bag on the chair, e.g., against the force of wind in an outdoor setting.
Paperbax, Llc


Method and eye detection from glints


A method of determining the position of eyeballs within an image, the method including the steps of: (a) capturing a time series of image frames illuminated in a predetermined temporal manner by at least two spaced apart light sources, by at least one imaging sensor; (b) processing the image frames to determine specular reflection locations in the image frames; and (c) utilising the time series evolution of the location of the specular reflections to isolate corneal reflections from the determined specular reflection locations.. .
Seeing Machines Limited


Therapeutic agent for corneal epithelial disorder


A therapeutic agent for a corneal epithelial disorder, containing a mir-203 inhibitor; an agent for promoting proliferation of corneal epithelial cells, containing a mir-203 inhibitor; a liquid culture medium for use in the manufacture of a corneal epithelial sheet, containing a mir-203 inhibitor; and a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using a liquid culture medium containing a mir-203 inhibitor. According to the present invention, a therapeutic agent for a corneal epithelial disorder, an agent for promoting proliferation of corneal epithelial cells, a liquid culture medium for use in the manufacture of a corneal epithelial sheet, a method for producing a corneal epithelial sheet, including the step of culturing corneal epithelial cells using the liquid culture medium, and a method for treating a corneal epithelial disorder can be provided.
Senju Pharmaceutical Co., Ltd.


Wound pads


Wound pads for use, e.g., as cavity wound fillers, having shapes with rounded corners, the projection on an x-y plane of at least one corner having a curvature distinct from that of the projection of the other corners. Negative pressure systems and kits comprising such wound pads, and methods of using such wound pads..
MÖlnlycke Health Care Ab


Diagnosis system and diagnosis method


A diagnosis system and a diagnosis method are provided. More specifically, embodiments of the present disclosure relate to a diagnosis system for detection of corneal degeneration impacting the biomechanical stability of the human cornea and a diagnosis method for detection of corneal degeneration impacting the biomechanical stability of the human cornea.
Wavelight Gmbh


Methods of fabricating polygon-sectional rodlike ingot and substrate with orientation marker or rounded corners, rodlike ingot and substrate


The present invention discloses a method of forming a polygon-sectional rodlike ingot having an orientation marker or rounded corners, a rodlike ingot and a sheet substrate so formed. The method comprises: selecting one of sides of the polygon-sectional rodlike ingot that is parallel to an axial direction thereof as a first feature of a surface orientation marker; forming a minisize notch, which is parallel to an edge, in the one of sides selected as the first feature in the axial direction of the rodlike ingot, as a second feature of the orientation marker; and processing the rodlike ingot to form rounded corners.
Institute Of Semiconductors, Chinese Academy Of Sciences


Basketball rebounder net


A rebounder may include a frame having tubes in the shape of an isosoles trapezoid with rounded corners. A net is attached to the frame.
Pro Performance Sports, L.l.c.


Micro-droplet delivery device and methods


Micro-droplet delivery devices and methods are described where the device may comprise a piezoelectric actuator having a piezoelectric chip that is operatively coupled to a drug package under a preloading force. The actuator is configured to generate an acoustic pressure within the drug package to dispense droplets of an agent from an aperture, e.g., to the corneal surface of the eye.

Hybrid lens system for head wearable display


A hybrid optical system for a head wearable display includes a central vision lens and a peripheral vision lens. The central vision lens approximately aligns with a cornea of a user to provide lensing to a central vision of the user when the user is looking straight forward.
Google Inc.


Portable corneal topographer


Portable corneal topographers and portable corneal topographer modules are disclosed. In one embodiment, a corneal topographer module comprises a housing having a first aperture and a second aperture formed therethrough; and a plurality of optical components disposed within the housing.
Smart Vision Labs


Liquid concentrated human milk fortifier containing hypoallergenic protein and lutein


The present invention is directed to concentrated liquid human milk fortifiers using extensively hydrolyzed casein as a protein source, a stabilizer system comprising octenyl succinic anhydride modified corn starch in combination with a low acyl gellan gum, and the carotenoid lutein.. .
Abbott Laboratories


Detecting facial liveliness


Methods, systems, and computer-readable storage mediums for detecting facial liveliness are provided. Implementations include actions of processing a facial image of a subject to determine a corneal reflection of an illuminator adjacent to the subject, the facial image being captured at a time point, determining an expected corneal reflection of the illuminator based on an illumination of the illuminator at the time point, comparing the determined corneal reflection of the illuminator to the expected corneal reflection of the illuminator to obtain a comparison result, and determining facial liveliness of the subject based on the comparison result..
Morphotrust Usa, Llc






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