|| List of recent Corn-related patents
| Systems and methods for corneal cross-linking with pulsed light|
Systems and methods for treating an eye select locations for making incisions in areas of the cornea according to astigmatic keratotomy or radial keratotomy, make incisions in the selected areas of the cornea, apply a cross-linking agent to the selected areas of the cornea, and deliver photoactivating light from a light source to the selected areas of the cornea to initiate cross-linking activity in the selected areas of the cornea.. .
| Transdermal delivery of beneficial substances effected by a hostile biophysical environment|
The present invention generally relates to the transdermal delivery of substances and, in some embodiments, to the transdermal delivery of beneficial substances by a hostile biophysical environment. In one aspect, various methods for the transdermal delivery of beneficial substances are disclosed.
| Method of analyzing image of cell in laminated structure and method of evaluating laminated structure for corneal transplantation|
A method of analyzing an image of a cell in a laminated structure may include the steps of: (a) fluorescently labeling a cell nucleus in the laminated structure having at least one cell layer and one or more other types of biomolecules; (b) acquiring a plurality of planar tomographic fluorescent labeled images in different height directions from the laminated structure for each type of fluorescently labeled biomolecules after the step (a); (c) superimposing a planar tomographic fluorescent labeled image group acquired in the step (b) to construct a three-dimensional tomographic image; (d) dividing the three-dimensional tomographic image constructed in the step (c) into one or two or more cell regions; (e) producing one planar stacked image for each divided cell region after the step (d); and (f) performing image analysis on each planar stacked image produced in the step (e) to analyze cells in the laminated structure.. .
| Visual display with illuminators for gaze tracking|
A visual display includes hidden reference illuminators adapted to emit invisible light for generating corneo-scleral reflections on an eye watching a screen surface of the display. The tracking of such reflections and the pupil center provides input to gaze tracking.
|Novel microfabricated instruments and methods to treat recurrent corneal erosions|
In one embodiment, the present invention provides a device and method for treating recurrent corneal erosion. In one embodiment, the method includes the steps of contacting an epithelium layer of a cornea with an array of glass micro-rods including a plurality of sharp features having a length that penetrates a bowman's layer of the eye, wherein the plurality of sharp features of the array of glass micro-rods produces a plurality of punctures in the bowman's layer of the eye that are of micro-scale or less.
|Reduced central corneal thickening by use of hydrophilic ester prodrugs of beta-chlorocyclopentanes|
Compositions and methods for treating glaucoma are provided. In particular hydrophilic ester prodrugs and their use to reduce central corneal thickening is provided..
|Gaze detection apparatus and gaze detection method|
A gaze detection apparatus includes: a first imaging unit which has a first angle of view and generates a first image; a second imaging unit which has a second angle of view narrower than the first angle of view, and generates a second image; a face detection unit which detects from the first image a face region; a coordinate conversion unit which identifies on the second image a first region corresponding to the face region or to an eye peripheral region containing the user's eye; a purkinje image detection unit which detects a corneal reflection image of a light source and the center of the user's pupil from within an eye region, identified based on the first region; and a gaze detection unit which detects the user's gaze direction or gaze position based on a positional relationship between the center of the pupil and the corneal reflection image.. .
|Chopper assembly for a harvesting implement|
A chopping assembly for a harvesting implement having a blade assembly, a housing, and a guide. The blade assembly is disposed within the housing and the guide directs cornstalks toward an input port on the housing.
|Positioning device for eye surgery and procedures|
The invention provides a positioning device for use in an examination, procedure or surgery of the eye. The positioning device includes an incurvate body with an upper peripheral edge having a first arc length, a lower peripheral edge having a second arc length, and a curved lateral portion therebetween.
|Method for measuring an eye|
A method for measuring the axial length of an eye using optical coherence tomography, during which a plurality of a-scans of the oct measurement are combined to an axial length, taking into account the alignment with which they were obtained, and taking into account the topography of the cornea. The distance of the front of the cornea from the retina is determined using oct while measuring or controlling the alignment of the measuring device to the eye in that the topography of the front of the cornea is measured or made available.
|Method and device for high-resolution retinal imaging|
The invention relates, according to one aspect, to a retinal imaging device including at least one source (lsa, lsr) for emitting a light beam in order to illuminate the retina of an eye (10) of a subject, a retinal imaging path including a detection device (12) having a detection plane (121) and an optical imaging system (l1, l5, l6), an analysis path including a device (15) for measuring optical defects having an analysis plane (151) for receiving a set of light rays backscattered by the retina and optical means for adjoining said analysis plane and a predetermined plane in the input space of said imaging system of the imaging path, a correction device (14) shared by said analysis and imaging paths, which includes a correction plane (141) and which is intended to correct, in said correction plane, the light rays from said emission source and backscattered by the retina according to the optical defects measured by the device for measuring optical defects. The retinal imaging device further includes a light blackout system (20), which is positioned in an adjacent plane or which coincides with said correction plane, or which is positioned in an image plane of said correction plane located on an optical path shared by the analysis and imaging paths, and which is sized so as to at least partially black out the reflections of the light rays from said emission source by the corneal surface..
|Corneal stromal mapping|
A method of measurement is presented. A method of measurement according to some embodiments of the present invention includes obtaining a first measurement from a first imaging method; obtaining a second measurement from a second imaging method; combining the first and the second measurement to obtain a structural information and an image representation of a structure of an eye; calculating at least one shape parameter from the structural information; and displaying the image representation of the structure of the eye..
|Methods of obtaining ophthalmic lenses providing the eye with reduced aberrations|
The present invention discloses methods of obtaining ophthalmic lens capable of reducing the aberrations of the eye comprising the steps of characterizing at least one corneal surface as a mathematical model, calculating the resulting aberrations of said corneal surface(s) by employing said mathematical model, selecting the optical power of the intraocular lens. From this information, an ophthalmic lens is modeled so a wavefront arriving from an optical system comprising said lens and corneal model obtains reduced aberrations in the eye.
|Ocular collar stent for treating narrowing of the irideocorneal angle|
An ocular stent for insertion in an anterior chamber of an eye is provided. The stent facilitates the restoration of the structure of an irideocorneal angle of the anterior chamber for treating structural changes from ocular aging.
|Combined wavefront and topography systems and methods|
Methods, software, and systems are provided for determining an ablation target shape for a treatment for an eye of a patient. Techniques include determining wavefront information from the eye of the patient with a wavefront eye refractometer, determining anterior corneal shape information from the eye with a corneal topography device, and combining the wavefront information and the anterior corneal shape information to determine the ablation target shape..
|Laser instrument for eye therapy|
A laser instrument for therapy on the human eye, designed for surgery of the cornea, the sclera, the vitreous body or the crystalline lens, especially suitable for use in immediate succession with other instruments for eye diagnosis or eye therapy, in such a way that during the alternating use of the various instruments, the eye or at least the patient preferably remains in a predetermined position and alignment within one and the same treatment area.. .
|Laser beam ophthalmological surgery method and apparatus|
This invention is related to refractive eye surgery and specifically regarding guiding a laser beam through free space using a set of rotatable mirrors to guide said laser beam into a hand piece module that converts the laser beam into a two dimensional random overlapping scanning parallel laser beam that is delivered to the eye for ablation of cornea tissue to reshape the cornea of the eye. The rotating mirror set module allows a hand piece having an eye stabilization and distance control unit to be positioned by the surgeon onto a patient's eye for performing the surgery..
|Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion|
An ophthalmic solution is provided. The ophthalmic solution is hypertonic.
|Hypertonic dextran solution and methods of treating and preventing recurrent corneal erosion|
An ophthalmic solution is provided. The ophthalmic solution is hypertonic.
|High-strength collagen fiber membrane and a manufacturing method thereof|
The object of the present invention is to provide a collagen fiber membrane, which has sufficient strength and can be used as a cell culture substrate, a scaffold material for regenerative medicine (for example, material for tissue engineering of cartilage, bone, ligament, corneal stroma, skin, or liver), an implantation material (for example, wound dressing material, bone grafting material, hemostatic material, anti-adhesive material) or a carrier for drug delivery. The object of the present invention can be solved by a fish-derived collagen fiber membrane, characterized in that (1) a tensile strength is 30 mpa or more, (2) a density determined by the gravimetric method, is 0.4 g/cm3 or more, and (3) an average membrane thickness is 1 μm to 2 mm, and a variation in membrane thickness is plus or minus 30%, relative to the average membrane thickness..
|Microwave popcorn bag|
A microwaveable popcorn container may be fashioned from glassine or similar materials to provide a susceptor-free, biodegradable, and/or compostable container for cooking microwave popcorn. The material of the container may be translucent in order to advantageously permit inspection of contents during cooking, as well as evaluation of the completeness of kernel popping after microwaving..
|Contact lens use in the treatment of an ophthalmologic condition|
The disclosure relates to the use of contact lenses for treating ophthalmologic conditions, such as presbyopia, induced myopia, computer vision syndrome, insufficient accommodation, or a condition associated with insufficient accommodation. The contact lens may be selected based on a measured sagittal depth and/or eccentricity of the cornea.
|Line-of-sight direction determination device and line-of-sight direction determination method|
A line-of-sight direction determination device includes: a line-symmetric position determiner that determines that the corneal reflection image of a left eye or a right eye is located at a line-symmetric position with respect to the center line of the pupils of the left and right eyes; and a line-of-sight direction determiner that determines, from the line-symmetric position determination result, a line-of-sight direction at a specific position including the installation position of an imaging unit or an irradiation unit at the substantially same position as the imaging unit. The line-of-sight direction determination device determines that the corneal reflection image is line symmetric and, from this line symmetry property, determines a specific line-of-sight direction..
|Tps tools and methods for the surgical placement of intraocular implants|
Provided herein are alignment systems, computer-implemented systems and methods utilizing the same for planning an optimal surgical implantation of asymmetric optics into one or both eyes of a patient and/or correcting astigmatism thereof. The methods generally comprise obtaining reference data comprising the surgical procedure plan, the reference image and the corneal topographic measurements for the patient's eye, determining an optimal placement angle of an optical zone on the cornea from the reference data and placing the asymmetric optic into the eye to match the determined optimal placement angle.
|Ophthalmological device and method for the treatment of corneal diseases|
An ophthalmological device (10) for the treatment of corneal diseases such as keratocanus and glaucoma, comprises a moulding head (12), a suction body (14) and a uv lamp (15). The moulding head (12) has a hollow cylindrical configuration and includes a rigid moulding lens (18) for shaping the cornea of an eye (11) of a patient.
|Grain fraction extraction material production system|
Specifically, a dry corn fractionation system which operates to produce an endosperm fraction which can be concurrently of greater purity at greater yield than obtainable from corn milling or dry corn milling processes.. .
|Methods and compositions for treating keratin hyperproliferation disorders|
A method for keratin hyperproliferation disorders such as corns, calluses, or keratosis pilaris (kp) by administering to a subject experiencing the disorder a therapeutically effective amount of an rna sequence which inhibits expression of a gene encoding for a keratin selected from the group consisting of k6a, k6b, k16, k17, and combinations thereof.. .
|Inversion marking for contact lenses|
An ophthalmic lens incorporating clearly identifiable, highly visible inversion marking(s) that become invisible when placed on the eye may be utilized to allow an individual to easily distinguish between the normal state of the lens and the inverted state of the lens. The ophthalmic lens comprises a thin material layer capable of changing its optical state from diffusive light scattering, colored, or both, to invisible transparent at the corneal temperature of a normal person, at the influence of ambient light, or a combination thereof..
|Composition for a topical ophthalmic clear colloidal liquid which undergoes a liquid-gel phase transition in the eye|
The present invention is directed to a topical ophthalmic composition for a liquid comprised of clear colloidal polar nanolipids delivered in submicron sized particles, aqueous colloidal lubricants, aqueous polymers, emulsifies, and a unique stabilizing buffer system, which undergoes a liquid-gel phase transition in the eye. Said composition is designed to deliver advanced eye lubricants, protect the three (3) layers of corneal film from dryness, and provide a unique system of dry eye treatment that addresses and treats all three layers of corneal tear film.
|Methods and apparatus to identify eye coverings for vision|
Methods and apparatus can fit coverings to treat eyes. The covering can be identified so as to provide improved flow of tear liquid under the covering.
|Ophthalmologic apparatus and ophthalmologic method|
In order to automatically determine whether an eye to be inspected is an iol eye by using bright spot images on a cornea for inspection at high accuracy, an ophthalmologic apparatus is provided with: a light beam projecting unit for projecting a light beam on the cornea of the eye to be inspected; a light receiving unit including an image pickup element for receiving a reflection light beam obtained by reflection of the light beam projected by the projecting unit to obtain cornea bright spot images from the cornea of the eye to be inspected; and an iol eye determining unit for determining whether the eye to be inspected is the iol eye based on the cornea bright spot images received by the light receiving unit.. .
|Intraocular lens design method and intraocular lens|
Provided is a technique which, in the design of intraocular lenses, simplifies design work and makes it possible for aberration of the entire eyeball to more precisely match a target value when the designed intraocular lens is inserted into a patient's eye. This intraocular lens design method involves deriving an intraocular lens aberration target value from the aberration of the cornea and anterior chamber and a set value of the total eyeball aberration (s102), and determining an intraocular lens shape such that the at least the aberration of the intraocular lens coincides with the target value (s103-s107).
|Eye therapy system|
Heat is generated in corneal fibrils in a cornea of an eye according to a selected pattern. The heat causes the corneal fibrils corresponding to the selected pattern to transition from a first structure to a second structure.
|Eye therapy system|
Embodiments apply a cross-linking agent to a region of corneal tissue. The cross-linking agent improves the ability of the corneal tissue to resist undesired structural changes.
|Extended wear ophthalmic lens|
A method for making a silicone hydrogel contact lens is provided. In one embodiment, a prepolymer mixture is polymerized in a lens mold in an atmosphere having less than about 10000 ppm oxygen to form a silicone hydrogel contact lens suitable for extended wear as characterized by producing less than 10% corneal swelling after a period of continuous wear of 7 days including normal sleep periods.
|System and method to achieve better eyelines in cg characters|
Systems and methods are provided to create better-looking animated eyes for cg characters. The systems and methods set the rigging of each eye to, rather than precisely converge on a target location, converge but be rotationally or angularly offset by a certain amount to simulate correct physical eye positioning and movements.
|Therapeutic agent for corneal sensory nerve damage containing semaphorin inhibitor as active ingredient|
Wherein r1 represents a hydrogen atom or a carboxyl group, r2 represents a hydrogen atom or a hydroxy group, r3 represents a hydrogen atom or a carboxyl group, and r4 represents a hydrogen atom or a hydroxy group.. .
|Ophthalmic pharmaceutical composition|
The present invention has an object to provide an ophthalmic pharmaceutical composition, particularly, an ophthalmic solution, ophthalmic ointment, ophthalmic wash, intraocular infusion solution, wash for anterior chamber, internal medicine, injection, or preservative for extracted cornea, which has improved therapeutic and/or prophylactic effects on the swelling, edema and walleye/cloudiness in the lens and/or the cornea induced by ophthalmic diseases including cataract and which is safe and successively used for a relatively long period of time. The present invention solves the above object by providing an ophthalmic pharmaceutical composition incorporated with a saccharide having a basic structure consisting of four glucose molecules bound together in a cyclic manner via a specific binding fashion..
|Method of reducing intraocular pressure in humans|
Provided herein is a method of reducing intraocular pressure (iop) in humans using n6-cyclopentyladenosine (cpa), cpa derivatives or prodrugs or enhanced cornea permeability formulations of cpa. In one embodiment, the invention is directed to cpa derivatives or prodrugs that are permeable to the cornea.
|Treatment and composition for achieving skin anti-aging benefits by corneum protease activation|
Novel methods and compositions for treating aged and environmentally damaged skin are disclosed which provide improvements in the skin's visual appearance, function and clinical/biophysical properties by activating at least one proteolytic enzyme in the skin's stratum corneum. The disclosed treatment methods involve topical application of a novel cosmetic composition containing a combination of a cationic surfactant such as n,n,-dimethyldodecyl amine oxide (dmdao), an anionic surfactant such as sodium dodecyl sulfate (sds), or monoalkyl phosphate (map) and a chelating agent such as ethylene diamine tetraacetate (edta) to stimulate a chronic increase in the replacement rate of the skin's stratum corneum by means of corneum protease activation.
|Treatment of ophthalmic conditions|
Ophthalmic conditions such as presbyopia, myopia, and astigmatism can be corrected by the use of a molding contact lens in combination with a pharmaceutical composition suitable for delivery to the eye. The molding contact lenses are preferably commercially available and are not specifically designed for orthokeratology.