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Congestive Heart Failure

Congestive Heart Failure-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid ...
Ardelyx, Inc
December 28, 2017 - N°20170368004

The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (ppar) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment ...
Methods and apparatus for renal neuromodulation
Medtronic Ardian Luxembourg S.a.r.l.
December 21, 2017 - N°20170361100

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e. G., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment ...
Compositions and method of use of a-type procyanidins
Mars, Incorporated
December 07, 2017 - N°20170348339

The invention relates to compositions, such as pharmaceuticals, foods, food additives, or dietary supplements, containing a-type procyanidins, and methods of use thereof, for prophylactic or therapeutic treatment of a human or a veterinary animal to treat or prevent no-responsive health conditions, treat hypertension, cardiovascular disease, coronary artery disease and/or vascular circulation disorders, prevent or reduce the risk of heart ...
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Methods and apparatus for renal neuromodulation
Medtronic Ardian Luxembourg S.a.r.l.
November 16, 2017 - N°20170326363

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e. G., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment ...
Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation
October 19, 2017 - N°20170296817

A patient suffering from congestive heart failure is at increased risk of cardiac arrhythmogenesis during sleep, particularly if experiencing central sleep apnea as a co-morbidity. Low intensity peripheral neurostimulation therapies that target imbalance of the autonomic nervous system have been shown to improve clinical outcomes. Thus, bi-directional autonomic regulation therapy is delivered to the cervical vagus nerve at an intensity ...
Methods for administration and methods for treating cardiovascular diseases with resiniferatoxin
October 19, 2017 - N°20170296506

The present application provides methods for treating cardiovascular conditions. The methods can include administering a transient receptor potential vanilloid 1 (trpv1) receptor agonist to an epidural space. The methods can be used to treat a variety of conditions such as hypertension, prehypertension, mild hypertension, severe hypertension, refractory hypertension, congestive heart failure and myocardial scarring.
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Apparatus for performing peritoneal ultrafiltration
Triomed Ab
October 05, 2017 - N°20170281848

An apparatus for ultrafiltration of a patient being overhydrated due to congestive heart failure, comprising a tube set including a connector for connection to a patient line for access to the peritoneal cavity of the patient. A flow pump is arranged for addition and removal outflow and inflow (recirculation) of fluid from/to the peritoneal cavity. An osmotic agent peristaltic ...
Chelator-targeting ligand conjugates for cardiovascular imaging
Cell>point, Llc
October 05, 2017 - N°20170281806

Disclosed are methods of imaging a site in a heart of a subject to detect cardiovascular disease that involve stressing a subject, administering to the stressed subject an effective amount of a radionuclide-labeled chelator-glucose analog conjugate, and imaging the heart of the subject by detecting a signal generated by the conjugate in the heart of the subject. Also disclosed are ...
Compounds, compositions and methods
Cytokinetics, Incorporated
September 21, 2017 - N°20170267638

Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
Intrinsic frequency hemodynamic waveform analysis
California Institute Of Technology
September 14, 2017 - N°20170258343

Hardware and software methodology are described for cardiac health measurement. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the dicrotic notch. The intrinsic frequencies provide metrics/ measures that correlate to the cardiac health of the subject. The systems may be used for monitoring a condition and/...
Trans-catheter ventricular reconstruction structures, methods, and systems for treatment of congestive heart failure and other ...
Bioventrix, Inc.
August 10, 2017 - N°20170224490

Embodiments described herein include devices, systems, and methods for reducing the distance between two locations in tissue. In one embodiment, an anchor may reside within the right ventricle in engagement with the septum. A tension member may extend from that anchor through the septum and an exterior wall of the left ventricle to a second anchor disposed along a surface ...
Sphinogosine-1-phosphate receptor modulators for treatment of cardiopulmonary disorders
The Scripps Research Institute
August 03, 2017 - N°20170217963

The invention provides compounds effective as sphingosine-1-phosphate receptor modulators for treatment of cardiopulmonary diseases, such as hypertension (including malignant hypertension), angina, myocardial infarction, cardiac arrhythmias, congestive heart failure, coronary heart disease, atherosclerosis, angina pectoris, dysrhythmias, cardiomyothopy (including hypertropic cardiomyothopy), heart failure, cardiac arrest, bronchitis, asthma, chronic obstructive pulmonary disease, cystic fibrosis, croup, emphysema, pleurisy, pulmonary fibrosis, pneumonia, pulmonary embolus, ...
Use of ribose for treatment of subjects having congestive heart failure
Ribocor, Inc.
August 03, 2017 - N°20170216330

A method for treating a human subject having congestive heart failure is disclosed herein. An exemplary method includes orally administering a 10 g to 50 g dose of d-ribose daily to a subject having congestive heart failure, wherein the d-ribose is administered in a single dose after fasting, and the administration of d-ribose is continued over a period of time effective to ...
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Systemic delivery of virus vectors encoding urocortin-2 and related genes to treat diabetes-related cardiac dysfunctions ...
The Regents Of The University Of California
June 29, 2017 - N°20170182129

In alternative embodiments, provided are methods for treating, ameliorating or protecting (preventing) congestive heart failure (chf) or a diabetes-related cardiac dysfunction, comprising: providing a urocortin 2-encoding and/or a urocortin 3-encoding nucleic acid, transcript or message, or gene, operatively linked to a transcriptional regulatory sequence, optionally contained in an expression vehicle or a vector such as an adeno-associated virus (aav), ...
Pulmonary artery implant apparatus and methods of use thereof
June 22, 2017 - N°20170172771

The present invention relates to an implantable apparatus and methods of use thereof for treating congestive heart failure. An apparatus of this invention may be anchored by implantation of a section of the apparatus within in a branch pulmonary artery, for example the left pulmonary artery, which then positions and anchors another section, for example a device frame section of ...
Treating dysfunctional cardiac tissue
Bioventrix, Inc.
June 08, 2017 - N°20170156865

Medical devices, systems, and methods reduce the distance between two points in tissue, often for treatment of congestive heart failure and often in a minimally invasive manner. An anchor is inserted along an insertion path through a first wall of the heart. An arm of the anchor is deployed and rotationally positioned according to a desired alignment. Application of tension ...
Treatment of congestive heart failure and other cardiac dysfunction using a gdf15 modulator
Aveo Pharmaceuticals, Inc.
May 18, 2017 - N°20170137505

The invention provides methods and compositions of treating a subject having a cardiac-related disorder such as congestive or chronic heart failure (chf), cardiac hypertrophy, cardiac hypotrophy, and other cardiac myopathies/dystrophies. The methods comprise administering an effective amount of a composition that modulates, for example, reduces or inhibits, gdf 15 activity in the subject.
Preparation of (r,r)-fenoterol and (r,r)- or (r,s)-fenoterol analogues and ...
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
March 23, 2017 - N°20170081276

This disclosure concerns the discovery of (r,r)- and (r,s)-fenoterol analogues which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogues are provided. Also provided are pharmaceutical compositions including the disclosed (r,r)-fenoterol and fenoterol analogues, and methods of using such compounds and compositions for the treatment of cardiac disorders ...
Methods for renal neuromodulation
Medtronic Ardian Luxembourg S.a.r.l.
March 23, 2017 - N°20170080230

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e. G., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment ...
Method and apparatus for performing peritoneal ultrafiltration
Triomed Ab
March 16, 2017 - N°20170072125

Method and apparatus for ultrafiltration of a patient being overhydrated due to congestive heart failure, comprising a cassette having four inlets/outlets. A patient tube is connected to a patient connector, intended to be connected to a patient line for access to a peritoneal cavity of the patient. The patient tube comprises a flow pump for addition and removal of ...
Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
Janssen Pharmaceutica Nv
March 16, 2017 - N°20170071970

The present invention is directed to the use of co-therapy comprising administration of canagliflozin and phentermine for the treatment of obesity and obesity related disorders. More particularly, the present invention is directed to co-therapy for treating obesity, for promoting weight loss and/or for suppressing appetite; for treating, delaying, slowing the progression of and/or preventing metabolic disorders (including for ...
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