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Colorectal

Colorectal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and compositions for detecting colorectal neoplasias using micro rnas
University Of Louisville Research Foundation, Inc.
October 12, 2017 - N°20170292161

Methods of detecting or predicting the presence of colorectal neoplasia are described based on the amounts of particular mirnas in plasma.
Compositions and methods for diagnosis and prognosis of colorectal cancer
Onconome, Inc.
October 05, 2017 - N°20170285032

Certain embodiments of the present invention provide methods and compositions related to the detection of colorectal cancer based upon the identification of biomarkers and combinations of biomarkers that indicate the present of colorectal cancer. One embodiment of the present invention provides a method for detecting colorectal cancer in a subject by obtaining a biological sample from the subject; detecting one ...
Methods and nucleic acids for analyses of colorectal cell proliferative disorders
Epigenomics Ag
October 05, 2017 - N°20170283880

The invention provides methods, nucleic acids and kits for detecting, or for detecting and distinguishing between or among colorectal cell proliferative disorders. The invention discloses genomic sequences the methylation patterns of which have utility for the improved detection of and differentiation between said class of disorders, thereby enabling the improved diagnosis and treatment of patients.
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Colorectal Patent Applications
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Predictive and prognostic biomarkers related to anti-angiogenic therapy of metastatic colorectal cancer
Regeneron Pharmaceuticals, Inc.
October 05, 2017 - N°20170281725

The present invention provides methods for treating metastatic cancer comprising identifying subjects who will respond favorably to anti-vegf therapy. According to certain aspects of the invention, subjects are identified based on their expression level of one or more predictive biomarkers. Favorable response to anti-vegf therapy is indicated by high expression levels of certain biomarkers or by low expression levels of ...
Method of analysis allowing avoidance of surgery
Miodx
September 28, 2017 - N°20170275702

A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) dna methylation of tumor suppressor genes; (c) non-coding rna expression (microrna profiling); and (d) long non-coding rna expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, ...
Methods for detection and treatment of colorectal cancer
Wisconsin Alumni Research Foundation
September 21, 2017 - N°20170269089

This invention provides methods, reagents, and diagnostic and prognostic markers useful for minimally invasive identification, diagnosis, and therapeutic intervention in individuals with colorectal cancers, or individuals who may be susceptible to developing colorectal cancers.
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Colorectal Patent Applications
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  • 101+ full patent PDF documents of Colorectal-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Detection method
Commonwealth Scientific And Industrial Research Organisation
September 14, 2017 - N°20170260585

The present invention relates generally to an array of nucleic acid molecules, the expression profiles of which characterise the anatomical origin of a cell or population of cells within the large intestine. More particularly, the present invention relates to an array of nucleic acid molecules, the expression profiles of which characterise the proximal or distal origin of a cell or ...
Mutations in the extracellular domain iii of epidermal growth factor receptor gene
FundaciÓ Institut Mar D'inversigacions MÈdiques (imim)
September 14, 2017 - N°20170260250

The invention relates to new identified mutations in the epidermal growth factor receptor gene, leading to amino acidic changes which highly correlate with the resistance to a therapy regimen comprising cetuximab. The invention includes peptide sequences and primers to detect the mutations, as well as kits for predicting the response of a subject to a therapy regime comprising cetuximab. In ...
Surgical instrument for colorectal polyp removal
FundaciÓ Institut Mar D'inversigacions MÈdiques (imim)
September 07, 2017 - N°20170252023

Disclosed are various embodiments of a surgical instrument for colorectal polyp removal. In various embodiment, the surgical instrument has an elongate flexible tubular sheath having a proximal end and a distal end, a snare having a loop and controlled by a pair of wires, and a biopsy forceps having a pair of jaws sized to fit within the loop of ...
Methods and compositions for inhibition of ras
Araxes Pharma Llc
August 31, 2017 - N°20170247376

Inhibitors of ras protein, methods to modulate the activity of ras protein, and methods of treatment of disorders mediated by ras protein are provided. A method for regulating activity of a k-ras, h-ras or n-ras mutant protein with a compound is described. Disorders that can be treated include cancer, such as hematological cancer, pancreatic cancer, myh associated polyposis, colorectal cancer, ...
Automatic region-of-interest segmentation and registration of dynamic contrast-enhanced images of colorectal tumors
Agency For Science, Technology And Research
August 24, 2017 - N°20170243349

A method for dynamic contrast enhanced (dce) image processing and kinetic modeling of an organ's region-of-interest is provided. The method includes deriving at least a contour of an exterior of the organ's region-of-interest from one or more of a plurality of images; generating a spline function in response to the derived contour of the exterior of the organ's region-of-interest from ...
Methionine aminopeptidase overexpression in the peripheral blood and peripheral blood mononuclear cells is a marker ...
Vastcon
August 24, 2017 - N°20170242013

A method of screening/prognosis/diagnosis for colorectal cancer (crc) wherein methionine aminopeptidase 2 (metap2) levels are detected in a non-tumor sample such as peripheral blood, peripheral blood mononuclear cells (pbmc) or lymphocytes. Based on the metap2 levels, the individual may be selected for further testing.
Method of multivariate molecule analysis
Miodx
August 17, 2017 - N°20170233825

A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) dna methylation of tumor suppressor genes; (c) non-coding rna expression (microrna profiling); and (d) long non-coding rna expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, ...
Colorectal Patent Pack
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Colorectal Patent Applications
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  • 101+ full patent PDF documents of Colorectal-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Prophylaxis of colorectal and gastrointestinal cancer
Centre National De La Recherche Scientifique (cnrs)
August 17, 2017 - N°20170233469

The present disclosure provides methods and compositions useful for preventing gastrointestinal and/or colorectal cancer in animals, including humans, having pre-cancerous adenomatous polyps. The present disclosure provides compositions comprising anti-pg antibodies suitable for use in the methods of the disclosure. The present disclosure also provides methods and compositions useful for monitoring the efficacy of anti-pg treatment in subjects with pre-cancerous ...
Cancer therapeutics
University Of Virginia Patent Foundation
August 17, 2017 - N°20170233375

This invention relates to compounds that bind to wild-type cbfβ and inhibit cbfβ binding to runx proteins. The potent compounds of the invention inhibit this protein-protein interaction at low micromolar concentrations, using allosteric mechanism to achieve inhibition, displace wild-type cbfβ from runx1 in cells, change occupancy of runx1 on target genes, and alter gene ...
Compositions and methods for treating colorectal cancer
Georgia State University Research Foundation, Inc.
August 10, 2017 - N°20170224759

The present invention relates to methods of treating a patient who has colorectal cancer and to methods of reducing the likelihood that a patient will develop or experience a recurrence of colorectal cancer. The methods comprise a step of introducing, to the patient, an effective amount of an agent that targets an intestinal h−-coupled di/tripeptide transporter (pept1). ...
Composition for diagnosis of liver metastasis of colorectal cancer and the use thereof
Samsung Life Public Welfare Foundation
August 03, 2017 - N°20170218373

The present disclosure relates to a composition for diagnosis of liver metastasis of colorectal cancer and the use thereof, and more particularly to a composition for diagnosis of liver metastasis of colorectal cancer, which comprises either a substance for measuring the mrna level of ccl7 (chemokine (c-c motif) ligand 7) gene or a substance for measuring the level of a protein ...
Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
Precision Biologics, Inc.
August 03, 2017 - N°20170218080

The present invention provides for purified or highly pure recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens (cpaa), along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to said nucleic acids and uses for said sequences.
Method of diagnosing neoplasms
Commonwealth Scientific And Industrial Research Organisation
July 27, 2017 - N°20170211152

The present invention relates generally to nucleic acid molecules, the rna and protein expression profiles of which are indicative of the onset, predisposition to the onset and/or progression of a neoplasm. More particularly, the present invention is directed to nucleic acid molecules, the expression profiles of which are indicative of the onset and/or progression of a large intestine ...
Bard1 isoforms in lung and colorectal cancer and use thereof
Hopitaux Universitaires De Geneve
July 20, 2017 - N°20170205415

The present invention relates to new bard1 isoforms specific to lung cancer and colorectal cancer, a method for detecting thereof and a method for treating and/or preventing lung cancer and colorectal cancer.
Diagnostic for colorectal cancer
Commonwealth Scientific And Industrial Research Organisation
July 20, 2017 - N°20170205414

The present invention provides a method for diagnosing or detecting colorectal cancer in a subject, the method comprising determining the presence and/or level of biomarkers selected from il-8, igfbp2, mac2bp, m2pk, il-13, dkk-3, epcam, mip1β, tgfβ1, and timp-1. The invention also relates to diagnostic kits comprising reagents for determining the presence and/or ...
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