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Colorectal patents

      

This page is updated frequently with new Colorectal-related patent applications.




 Treating bax(delta)2-positive cancer with chemotherapies targeting caspase 8 patent thumbnailTreating bax(delta)2-positive cancer with chemotherapies targeting caspase 8
Discovery of a new bax isoform, baxΔ2, in cancer cell lines and primary tumors is described. The baxΔ2 isoform resulted from combination of bax microsatellite mutation and alternative splicing bax exon 2.
Mumetel, Llc


 Method for diagnosing colorectal cancer from a human feces sample by quantitive pcr, primers and kit patent thumbnailMethod for diagnosing colorectal cancer from a human feces sample by quantitive pcr, primers and kit
The present invention relates to the field of detection of colorectal cancer (crc). Specifically it relates to methods for the early detection, risk screening and monitoring of crc and/or adenomatous polyps in a human subject based on the quantification of one or more 16s rdna bacterial sequences in feces.
Universitat De Girona


 Methods and compositions for assaying blood levels of legumain patent thumbnailMethods and compositions for assaying blood levels of legumain
In one aspect, a homogenous assay method for determination of blood levels of legumain molecules (an asparaginyl endopeptidase) is disclosed. In one aspect, the assay utilizes specific sizes of nanoparticles that are coated with antibody or antibodies specifically towards legumain molecule or its fragment(s).

 Methods and compositions for assaying blood levels of legumain patent thumbnailMethods and compositions for assaying blood levels of legumain
In one aspect, a homogenous assay method for determination of blood levels of legumain molecules (an asparaginyl endopeptidase) is disclosed. In one aspect, the assay utilizes specific sizes of nanoparticles that are coated with antibody or antibodies specifically towards legumain molecule or its fragment(s).

 Test kits and uses thereof patent thumbnailTest kits and uses thereof
This invention relates to test kits, methods and compositions for evaluating expression of genetic markers useful in determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to pct test kits and their use to determine expressing of genetic markers based on cell proliferation signatures..
Pacific Edge Limited


 Neurotensin-induced tumor formation is regulated by micro rna 133a-aftiphilin-dependent receptor recycling patent thumbnailNeurotensin-induced tumor formation is regulated by micro rna 133a-aftiphilin-dependent receptor recycling
This application discloses methods of treating, preventing, and diagnosing colorectal cancer and ibd in a subject comprising administering an effective dose of antisense mir-133α or aftph to the subject or detecting expression levels of mir-133α and aftph.. .
The Regents Of The University Of California


 Site-specific conjugation of linker drugs to antibodies and resulting adcs patent thumbnailSite-specific conjugation of linker drugs to antibodies and resulting adcs
The present invention relates to antibody-drug conjugates (adcs) wherein a linker drug is site-specifically conjugated to an antibody through an engineered cysteine, and their use as a medicament, notably for the treatment of human solid tumours and haematological malignancies, in particular breast cancer, gastric cancer, colorectal cancer, urothelial cancer, ovarian cancer, uterine cancer, lung cancer, mesothelioma, liver cancer, pancreatic cancer, prostate cancer, and leukaemia.. .
Synthon Biopharmaceutical B.v.


 Method for colorectal cancer detection patent thumbnailMethod for colorectal cancer detection
The present invention provides an oligopeptide specific to colorectal cancer cells, which are selected from a group of peptide sequences consisting of seq id: no. 1 to seq id: no.
National Tsing Hua University


 Detecting colorectal neoplasm patent thumbnailDetecting colorectal neoplasm
Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.. .
Exact Sciences Corporation


 Method for supporting diagnosis of risk of colorectal cancer recurrence, treatment of colorectal cancer, and administration of anticancer drug patent thumbnailMethod for supporting diagnosis of risk of colorectal cancer recurrence, treatment of colorectal cancer, and administration of anticancer drug
Disclosed is a method for supporting a diagnosis of a risk of colorectal cancer recurrence, including the steps of: performing a first measurement to measure the levels of expression of a plurality of genes selected from a first gene group present in a region from 18q21 to 18q23 on the long arm of chromosome 18 in a biological sample collected from a patient with colorectal cancer, a second measurement to measure the levels of expression of a plurality of genes selected from a second gene group present in a region from 20q11 to 20q13 on the long arm of chromosome 20, and a third measurement to measure the levels of expression of a plurality of genes selected from a third gene group including angptl2, axl, c1r, c1s, calhm2, ctsk, dcn, emp3, grem1, itgav, klhl5, mmp2, rab34, selm, srgap2p1, and vim; and determining the risk of colorectal cancer recurrence of the patient based on the levels of expression measured in the measurement step.. .
Sysmex Corporation


Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer

Methods for selecting whether to administer an anti-angiogenic therapeutic agent to a subject include steps of measuring the expression levels of one or more biomarkers selected from table 2 or table 3 in a sample from the subject; assessing from the expression levels of the one or more biomarkers whether the sample from the subject is positive or negative for a biomarker signature, wherein if the sample is positive for the biomarker signature an anti-angiogenic therapeutic agent is contraindicated. Related prognostic methods and treatment methods are also provided.
Almac Diagnostics Limited

Colorectal cancer drug, and predicting prognosis of colorectal cancer patient

The purpose of the present invention is to provide a colorectal cancer drug that uses microrna exhibiting outstanding effectiveness in colorectal cancer patients, particularly colorectal cancer patients having a mutated kras gene. Mir4689 and/or mir4685-3p can suppress the growth of colorectal cancer cells, particularly colorectal cancer cells having a mutated kras gene, and thus exhibit an effective antitumor effect..

Mir-320e and colorectal cancer

Embodiments provide methods and compositions related to determining treatments for colorectal cancer patients by detection and analysis of the expression level of mirna such as mir-320e in the patients. Embodiments provide predictive, prognostic and/or diagnostics methods by identifying mirnas that are useful for clinical management of cancer patients, particularly colorectal cancer patients or patients at risk or determined to have colorectal cancer.
Baylor Research Institute

Treatment of cancer

In one aspect, the disclosure features, a method of treating a cancer, e.g. colorectal cancer, e.g., rectal cancer, in a subject with a cyclodextrin containing polymer (“cdp”)-camptothecin conjugate, particle or composition or camptothecin derivative conjugate, particle or composition described herein, e.g., crlx101.
Cerulean Pharma Inc.

Methods and kits for identifying pre-cancerous colorectal polyps and colorectal cancer

Methods and kits for identifying a subject having pre-cancerous advanced polyps or colorectal cancer based on the expression profile(s) of specific mrna biomarkers. Methods and kits for diagnosing, preventing, managing therapy, monitoring and identifying predisposition to colorectal cancer..
Bio-marcare Technologies Ltd.

Histone deacetylase inhibitors

Fused bicycle indol, indoline, azoindole, or azoindoline compounds of formula (i) set forth herein. Also disclosed are pharmaceutically acceptable salts of these compounds and pharmaceutical compositions containing the same.
National Health Research Institutes

Methods for preventing or reducing colon carcinogenesis

The present invention is directed in part to methods of preventing or reducing colon carcinogenesis comprising administering to a patient at risk of colorectal cancer, a pharmaceutical preparation comprising disclosed chemopreventive. In another aspect, the invention is directed to methods attenuation of oxygen free radicals comprising administrating to a patient in need thereof an antioxidant effective amount of a compound represented by formula i, iia or iib as disclosed herein..
Nogra Pharma Limited

Treatment planning and evaluation for rectal cancer via image analytics

Methods and apparatus associated with predicting colorectal cancer tumor invasiveness are described. One example apparatus includes a set of circuits, and a data store that stores radiological images of tissue demonstrating colorectal cancer.
Case Western Reserve University

Therapeutic molecules & deviates for crc

The chemically synthesized compound tricin 7-o-beta-d-glucopyranoside, native to the plant deschampsia antarctica and present in aqueous extracts of the plant deschampsia antarctica said compound having the ability to inhibit tumor growth in mammals with colorectal carcinoma.. .
Antartina Llc

Methods and biomarkers for analysis of colorectal cancer

The present invention relates to methods and biomarkers (e.g., protein biomarkers) for detection of colorectal cancer in biological samples (e.g., tissue samples, biopsy samples, stool samples, blood samples, plasma samples, serum samples). In some embodiments, methods and biomarkers of the present invention find use in detection of colon cancer, providing a prognosis to colorectal cancer patients, and in companion diagnostics..
Oslo Universitetssykehus Hf

G-alpha interacting vesicle associated protein (giv) as a predictive marker in stage ii colorectal cancer

Provided herein are methods of analyzing stage ii colorectal cancer (crc) samples (such as those that are mis-match repair proficient, pmmr), by scoring g-alpha interacting vesicle associated protein (giv, also known as girdin) full-length (giv-fl) expression in combination with lymphovascular invasion (lvi) status or clinical variables. The disclosed methods can be used to identify giv-fl expressing tumors that are likely to recur (high risk) and those that are not likely to recur (high risk).
Hoffmann-la Roche, Inc.

Detection of elevated levels of phosphorylated mcm and increasing mcm phosphorylation capacity

Identified herein is a novel post-translational modification of mcm2, wherein the residue of serines 53 and 108 are phosphorylated. Ddk phosphorylates mcm2 at serines 53 and 108 when stimulated by treslin.
The Florida State University Research Foundation, Inc.

Composition or kit for diagnosing colorectal cancer incluidng cxcl7-measuring agent and diagnosing colorectal cancer using the same

Provided are a composition or a kit for diagnosing colorectal cancer including a cxcl7-measuring agent, and a method of diagnosing colorectal cancer using the same. According to the composition or the kit, and the method, colorectal cancer may be simply diagnosed with high diagnostic accuracy and specificity for colorectal cancer..
Samsung Life Public Welfare Foundation

Method and apparatus to diagnose the metastatic or progressive potential of cancer, fibrosis and other diseases

A method and apparatus for determining the progressive potential of a disease is disclosed. The forward to backward propagating second harmonic generation signal derived from a second harmonic generation instrument is used to assess the collagen microstructure of imaged body tissue by way of numerical values that are in turn used to determine the progressive or metastatic potential of the disease.
University Of Rochester

Dual targeting antisense oligonucleotides as apoptotic inhibtor therapeutic compostions and methods for their use in the treatment of cancer

Provided herein are compositions, method and uses for modulating iap activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (daso) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of birc6, ciap1 or survivin.



Colorectal topics:
  • Colorectal
  • Rectal Cancer
  • Colorectal Cancer
  • Methylation
  • Nucleic Acid
  • Antibodies
  • Pancreatic
  • Metastasis
  • Rectal Carcinoma
  • Colorectal Carcinoma
  • Expression Vector
  • Pancreatic Cancer
  • Lung Cancer
  • Breast Cancer
  • Transforming Growth Factor


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    This listing is a sample listing of patent applications related to Colorectal for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Colorectal with additional patents listed. Browse our RSS directory or Search for other possible listings.


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