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Colorectal

Colorectal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods of identifying proliferation signatures for colorectal cancer
Pacific Edge Limited
January 11, 2018 - N°20180010198

This invention relates methods and compositions for identifying colorectal cancer (crc) prognostic transcripts and groups of crc prognostic transcripts useful in determining the prognosis of cancer in a patient, particularly for gastrointestinal cancer, such as gastric or colorectal cancer. Specifically, this invention relates to crc cell culture-based methods to identify cell proliferation signatures.
Method of treating colorectal cancers using a pkc inhibitor
University Of South Florida
January 11, 2018 - N°20180008564

The subject invention pertains to methods of treating colorectal cancer by administering an atypical pkc inhibitor. The inhibitors of apkc useful in the methods of the instant invention include acpd, ica-1, dnda and ζ-stat. Also provided are methods of measuring the susceptibility of colon cancer cells of a subject to inhibitors of apkcs.
Novel immunotherapy against several tumors including gastrointestinal and gastric cancer
Immatics Biotechnologies Gmbh
January 04, 2018 - N°20180000896

A method of treating a patient who has gastric cancer, gastrointestinal cancer, colorectal cancer, pancreatic cancer, lung cancer, and/or renal cancer includes administering to said patient a composition containing a population of activated t cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated t cells that selectively recognize cells in ...
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Methods and compositions for detecting colorectal neoplasias
Case Western Reserve University
December 28, 2017 - N°20170369948

The disclosure provides methods for identifying genomic loci that are differentially methylated in colorectal neoplasias. Identification of methylated genomic loci has numerous uses, including for example, to characterize disease risk, to predict responsiveness to therapy, to non-invasively diagnose subjects and to treat subjects determined to have colorectal neoplasias.
Use of anti-pd-1 antibody in combination with anti-cd27 antibody in cancer treatment
Celldex Therapeutics, Inc.
December 28, 2017 - N°20170368172

This disclosure provides methods for treating cancer in a subject comprising administering to the subject an anti-pd-1 antibody and an anti-cd27 antibody. In some embodiments, the cancer is colorectal cancer, rectal cancer, colon cancer, lung cancer, melanoma, ovarian cancer, head and neck cancer, or any combination thereof.
Consensus coding sequences of human breast and colorectal cancers
The Johns Hopkins University
December 21, 2017 - N°20170362659

Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ˜90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not ...
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Colorectal Patent Applications
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inventor
  • 101+ full patent PDF documents of Colorectal-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Colon and pancreas cancer peptidomimetics
Precision Biologics, Inc.
December 21, 2017 - N°20170362288

The invention relates to a peptidomimetic of an npc-1 epitope on the muc5ac protein which is differentially expressed in pancreatic and colorectal cancer, and diagnostic and therapeutic usages. Further, antibodies that selectively bind the npc-1 epitope peptidomimetics and may be used in diagnostic and therapeutic methods.
Pharmaceutical composition comprising bicyclic nitrogen-containing aromatic heterocyclic amide compound as active ingredient
Precision Biologics, Inc.
December 21, 2017 - N°20170360781

[means for solution] as a result of intensive examination for creating a pharmaceutical composition for treating various types of cancer, the inventors of the present invention confirmed that a specific bicyclic nitrogen-containing aromatic heterocyclic amide compound has the effect of inhibiting mitochondrial complex i and activating ampk, and that a pharmaceutical composition comprising the compound as an active ingredient has ...
Method of assaying apolipoprotein ai for the in vitro diagnosis of colorectal cancer
Biomerieux
December 14, 2017 - N°20170356916

A method assaying the levels of expression apolipoprotein ai, apolipoprotein aii, e-cadherin, and galectin-3 in a biological sample from a person having or suspected of having colorectal cancer. The sample is remote from any tumor.
Method for estimating sensitivity to drug therapy for colorectal cancer
The University Of Tokyo
December 14, 2017 - N°20170356051

The present invention relates to a method for predicting responsiveness to cancer drug therapy for colorectal cancer. More particularly, the present invention relates to a method for predicting the responsiveness of a colorectal cancer patient to cancer drug therapy, the method comprising analyzing the level of dna methylation in a specimen comprising a colorectal cancer tissue, colorectal cancer cells, or ...
2,3-dihydro-1h-indole compounds
Eli Lilly And Company
December 14, 2017 - N°20170354641

The present invention relates to certain novel 2,3-dihydro-1h-indole compounds, pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, more particularly for the treatment of cancer selected from the group consisting of melanoma, acute myeloid leukemia, chronic lymphocytic leukemia, colorectal cancer, breast cancer, lung cancer, ovarian cancer, fallopian tube carcinoma, primary peritoneal carcinoma, cervical cancer, ...
Drug delivery polymers and uses thereof
Massachusetts Institute Of Technology
December 07, 2017 - N°20170348431

Described herein are platinum-based brush-arm star polymers (pt-basps), or a pharmaceutical composition thereof, for delivery of platinum-based agents, such as oxaliplatin. Also provided are methods and kits involving the pt-basps, or a pharmaceutical composition thereof, for treating proliferative diseases such as cancers (e. G., lung cancer, head-and-neck cancer, esophagus cancer, stomach cancer, breast cancer, pancreas cancer, colorectal cancer, liver cancer, ...
Methods and systems for metabolite and/or lipid-based detection of colorectal cancer and/or adenomatous ...
Universal Diagnostics, S.l.
November 30, 2017 - N°20170343567

Described herein are sets of metabolite and lipid (e. G., fatty acid) markers that can be used in the detection of early stage colorectal cancer and/or early development of adenomatous polyps. Presented herein are illustrative pathology-linked panels. In certain embodiments, the markers presented herein (or subsets thereof) are used as a panel for detecting either colorectal cancer or adenomatous ...
Colorectal Patent Pack
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Colorectal Patent Applications
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inventor
  • 101+ full patent PDF documents of Colorectal-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors
Glaxosmithkline Intellectual Property Development Limited
November 30, 2017 - N°20170340617

This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ...
Method for detecting methylation of colorectal cancer specific methylation marker gene for colorectal cancer diagnosis
Genomictree, Inc.
November 23, 2017 - N°20170335407

The present disclosure relates to a method for detecting methylation of the bowel-cancer-specific methylation marker gpm6a (nm_201591, glycoprotein m6a) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The ...
Method for detecting the methylation of colorectal-cancer-specific methylation marker genes for colorectal cancer diagnosis
Genomictree, Inc.
November 23, 2017 - N°20170335405

The present disclosure relates to a method for detecting cpg methylation of sdc2 (syndecan 2) gene, a kit for detecting cpg methylation of sdc2 (syndecan 2) gene, and a method for detecting cpg methylation of sdc2 (syndecan 2) gene for a colorectal cancer diagnosis.
Pharmaceutical composition for adjunctively treating cancer
Taipei Medical University
November 23, 2017 - N°20170333502

The present invention provides a pharmaceutical composition for adjunctively treating cancer. Differing from conventional therapies commonly using anti-cancer drugs and/or radiation substances to cause the apoptosis of cancer cells, the present invention particularly adopts an ethanol extract of taiwanofungus camphorata (tcee), an ethanol extract of ganoderma lucidum (glee) or a combination of the tcee and the glee as the ...
Prevention, treatment, and amelioration of radiation induced enteritis
Taipei Medical University
November 23, 2017 - N°20170333458

The present invention provides a new method of ameliorating and/or treating enteritis induced by radiation therapy, alone or in combination with other therapies, for the treatment oil for example, gastrointestinal malignancies, including colorectal, appendiceal, anal, or small bowel cancers; urogenital malignancies, including prostate, bladder, testicular, or penile cancers; gynecologic malignancies, including cervical, endometrial, ovarian, vaginal, or vulvar cancers; or ...
Peptides for targeting colorectal cancer, and medical use thereof
University Of Ulsan Foundation For Industry Cooperation
November 16, 2017 - N°20170328906

Provided is a peptide for targeting colorectal cancer, a composition for diagnosing radioresponsiveness-dependent prognosis of colorectal cancer using the peptide, and a drug delivery use of the peptide, wherein a functional peptide capable of targeting cancer has been discovered so as to implement personalized diagnosis and treatment for individual patients having cancer, in consideration of problems occurring during treatment in ...
Method for early detection of cancer
Go Therapeutics, Inc.
November 09, 2017 - N°20170322219

The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated o-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could ...
Novel aspirin derivatives and uses thereof
North Carolina Agricultural And Technical State University
November 09, 2017 - N°20170320810

The present invention provides novel aspirin derivatives useful for preventing and/or treating cancer. The novel compounds of this invention may be particularly useful for the prevention and/or treatment of cancers affecting the gastrointestinal system, such as colorectal cancer.
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