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Colorectal

Colorectal-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Anti-folate receptor alpha antibodies and uses thereof
Eisai R&d Management Co., Ltd.
June 15, 2017 - N°20170168078

Described herein are antibodies, and antigen-binding fragments thereof, that are specific for folate receptor alpha, related polynucleotides, expression vectors, and cells that express the described antibodies. Also provided are methods of using the described antibodies, and antigen-binding fragments thereof, and related kits. Provided herein are also methods for diagnosing cancers, such as breast cancer, thyroid cancer, colorectal cancer, endometrial cancer, ...
Methods for detecting and monitoring colorectal cancer
Regents Of The University Of Minnesota
June 08, 2017 - N°20170160280

A method for detecting and/or measuring circulating txa2 in a subject having or at risk of having colorectal cancer. Generally, the method includes obtaining a biological sample from the subject, measuring circulating txa2 in the biological sample, and identifying the subject as having colorectal cancer if the circulating txa2 in the biological sample is greater than a predetermined level. ...
Anti-c4.4a antibodies and uses thereof
Bayer Intellectual Property Gmbh
June 08, 2017 - N°20170158775

The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kda c4. 4a polypeptide, which is over expressed in several tumors, e. G. Lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the ...
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Marmelin analogs and methods of use in cancer treatment
Bayer Intellectual Property Gmbh
May 25, 2017 - N°20170144965

A pharmaceutical composition can include: a marmelin analog compound, and a pharmaceutically acceptable carrier having the compound. The compound can be present in a therapeutically effective amount to treat or inhibit a disease state. The disease state can be cancer. The cancer can be selected from brain cancers, head and neck cancers, thyroid cancers, gastrointestinal cancers, esophageal cancers, stomach cancers, ...
Biomarker for colorectal cancer
Interna Technologies B.v.
May 11, 2017 - N°20170130277

Methods of diagnosing colorectal cancer and precursors thereof using mirna biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.
Colorectal cancer detection kit or device, and detection method
National Cancer Center
May 11, 2017 - N°20170130274

It is intended to provide a kit or a device for the detection of colorectal cancer and a method for detecting colorectal cancer. The present invention provides a kit or a device for the detection of colorectal cancer, comprising a nucleic acid capable of specifically binding to a mirna in a sample from a subject, and a method for detecting ...
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Vegfr2/ang2 compounds
Eli Lilly And Company
May 04, 2017 - N°20170121411

The present invention relates to compounds that bind to human vascular endothelial growth factor receptor-2 (vegfr2) and human angiopoietin-2 (ang2), and may be useful for treating cancer, especially solid tumors driven by vegfr2 and ang2, including gastric, hepatocellular carcinoma, ovarian, colorectal, non-small cell lung, biliary tract, and breast cancers.
Use of protein s100a12 as a marker for colorectal cancer
Roche Diagnostics Operations, Inc.
April 27, 2017 - N°20170115294

The present invention relates to the diagnosis of colorectal cancer. It discloses the use of protein s100a12 in the diagnosis of colorectal cancer. It relates to a method for diagnosis of colorectal cancer from a stool sample, derived from an individual by measuring s100a12 in said sample. Measurement of s100a12 can, e. G., be used in the ...
Pharmaceutical composition for treating cancer in an individual subject suffering cancer
Ma Shen Kai Ruei Co., Ltd.
April 27, 2017 - N°20170112856

A pharmaceutical composition for treating cancer in an individual, comprising at least a pharmaceutically effective amount of a novel target hcc reversal signal substance, and a pharmaceutically acceptable ingredient comprising a vehicle, a carrier, a diluent or an excipient; and the novel target hcc reversal signal substance is a mixture that consisting of antroquinonol (aql), antrocinnamonin a (aca), antroquinonol b (...
Treating bax(delta)2-positive cancer with chemotherapies targeting caspase 8
Mumetel, Llc
April 20, 2017 - N°20170108504

Discovery of a new bax isoform, baxΔ2, in cancer cell lines and primary tumors is described. The baxΔ2 isoform resulted from combination of bax microsatellite mutation and alternative splicing bax exon 2. It is also discovered that baxΔ2 renders cancer cells sensitive to certain chemotherapeutic drugs that target caspase 8. Also provided are methods for treating colorectal cancer by ...
Method for diagnosing colorectal cancer from a human feces sample by quantitive pcr, primers and ...
Universitat De Girona
April 06, 2017 - N°20170096709

The present invention relates to the field of detection of colorectal cancer (crc). Specifically it relates to methods for the early detection, risk screening and monitoring of crc and/or adenomatous polyps in a human subject based on the quantification of one or more 16s rdna bacterial sequences in feces. It further relates to the use of said bacterial sequences ...
Methods and compositions for assaying blood levels of legumain
Universitat De Girona
March 30, 2017 - N°20170089910

In one aspect, a homogenous assay method for determination of blood levels of legumain molecules (an asparaginyl endopeptidase) is disclosed. In one aspect, the assay utilizes specific sizes of nanoparticles that are coated with antibody or antibodies specifically towards legumain molecule or its fragment(s). In one aspect, the assay is designed in a homogenous manner with a dynamic range ...
Methods and compositions for assaying blood levels of legumain
Universitat De Girona
March 30, 2017 - N°20170089909

In one aspect, a homogenous assay method for determination of blood levels of legumain molecules (an asparaginyl endopeptidase) is disclosed. In one aspect, the assay utilizes specific sizes of nanoparticles that are coated with antibody or antibodies specifically towards legumain molecule or its fragment(s). In one aspect, the assay is designed in a homogenous manner with a dynamic range ...
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Colorectal Patent Applications
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Neurotensin-induced tumor formation is regulated by micro rna 133a-aftiphilin-dependent receptor recycling
The Regents Of The University Of California
March 30, 2017 - N°20170088857

This application discloses methods of treating, preventing, and diagnosing colorectal cancer and ibd in a subject comprising administering an effective dose of antisense mir-133α or aftph to the subject or detecting expression levels of mir-133α and aftph.
Site-specific conjugation of linker drugs to antibodies and resulting adcs
Synthon Biopharmaceutical B.v.
March 23, 2017 - N°20170080103

The present invention relates to antibody-drug conjugates (adcs) wherein a linker drug is site-specifically conjugated to an antibody through an engineered cysteine, and their use as a medicament, notably for the treatment of human solid tumours and haematological malignancies, in particular breast cancer, gastric cancer, colorectal cancer, urothelial cancer, ovarian cancer, uterine cancer, lung cancer, mesothelioma, liver cancer, pancreatic cancer, ...
Method for colorectal cancer detection
National Tsing Hua University
March 16, 2017 - N°20170074882

The present invention provides an oligopeptide specific to colorectal cancer cells, which are selected from a group of peptide sequences consisting of seq id: no. 1 to seq id: no. 3. The oligopeptide specific to colorectal cancer cells of the present invention may be applied for colorectal cancer detection method having non-invasive, fast and convenient properties
Detecting colorectal neoplasm
Exact Sciences Corporation
March 16, 2017 - N°20170073772

Provided herein is technology relating to detecting neoplasia and particularly, but not exclusively, to methods, compositions, and related uses for detecting premalignant and malignant neoplasms such as colorectal cancer.
Method for supporting diagnosis of risk of colorectal cancer recurrence, treatment of colorectal cancer, and ...
Sysmex Corporation
March 16, 2017 - N°20170073770

Disclosed is a method for supporting a diagnosis of a risk of colorectal cancer recurrence, including the steps of: performing a first measurement to measure the levels of expression of a plurality of genes selected from a first gene group present in a region from 18q21 to 18q23 on the long arm of chromosome 18 in a biological sample collected from ...
Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer
Almac Diagnostics Limited
March 16, 2017 - N°20170073761

Methods for selecting whether to administer an anti-angiogenic therapeutic agent to a subject include steps of measuring the expression levels of one or more biomarkers selected from table 2 or table 3 in a sample from the subject; assessing from the expression levels of the one or more biomarkers whether the sample from the subject is positive or negative for a biomarker ...
Colorectal cancer drug, and method for predicting prognosis of colorectal cancer patient
Almac Diagnostics Limited
March 16, 2017 - N°20170073686

The purpose of the present invention is to provide a colorectal cancer drug that uses microrna exhibiting outstanding effectiveness in colorectal cancer patients, particularly colorectal cancer patients having a mutated kras gene. Mir4689 and/or mir4685-3p can suppress the growth of colorectal cancer cells, particularly colorectal cancer cells having a mutated kras gene, and thus exhibit an effective ...
Mir-320e and colorectal cancer
Baylor Research Institute
March 09, 2017 - N°20170067115

Embodiments provide methods and compositions related to determining treatments for colorectal cancer patients by detection and analysis of the expression level of mirna such as mir-320e in the patients. Embodiments provide predictive, prognostic and/or diagnostics methods by identifying mirnas that are useful for clinical management of cancer patients, particularly colorectal cancer patients or patients at risk or determined ...
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