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Codon

Codon-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Cis/trans riboregulators
Trustees Of Boston University
May 24, 2018 - N°20180142247

The present invention provides nucleic acid molecules, dna constructs, plasmids, and methods for post-transcriptional regulation of gene expression using rna molecules to both repress and activate translation of an open reading frame. Repression of gene expression is achieved through the presence of a regulatory nucleic acid element (the cis-repressive rna or crrna) within the 5′ untranslated region (5′ utr) of ...
Methods of modulating mrna stability and protein expression
Case Western Reserve University
May 17, 2018 - N°20180135061

A synthetic cdna which encodes a protein wherein at least one optimal or non-optimal codon in a wild type dna encoding the protein has been replaced respectively with one or more non-optimal codons or optimal codons encoding the same amino acid.. .
Construction and application of one innovative expression vector for virus-like particles
Chinese Academy Of Inspection And Quarantine
May 10, 2018 - N°20180127837

The present invention provides a novel virus-like particle expression vector ptmsca2c, which is constructed as follows: firstly, using plasmid ptrchis-ms2 as a starting vector and mutating the base t at position 5 of the gene sequence of ms2 bacteriophage 19mer packaging site on the plasmid ptrchis-ms2 into c through genetic mutation technologies to obtain a plasmid ptmsc; then, mutating valine ...
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Genetically modified probiotic for the treatment of phenylketonuria (pku) disease
University Of North Texas
May 03, 2018 - N°20180117101

A gmp adapted to provide the pal gene for the treatment of pku when administered orally. The gmp of the present invention may include a probiotic, a pal gene to be expressed using the probiotic, wherein the pal gene is functionally attached to a promoter and a ribosome binding site, and may be codon-optimized for expression in a certain host ...
Compositions and methods for making selenocysteine containing polypeptides
Yale University
April 19, 2018 - N°20180105854

Non-naturally occurring trnasec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring trnasec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mrna without the requirement of an secis element.
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of ...
Kempharm, Inc.
April 19, 2018 - N°20180104352

The presently described technology provides methods of treating a patient having moderate to severe pain, narcotic or opioid abuse or narcotic or opioid withdrawal. The presently described methods are carried out by comprising administering to the patient a pharmaceutically effective amount of a composition comprising acetaminophen and benzoate-hydrocodone hydrochloride.
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  • 98+ full patent PDF documents of Codon-related inventions.
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Abuse deterrent pharmaceutical compositions
Kvk-tech, Inc.
April 19, 2018 - N°20180104190

Abuse deterrent pharmaceutical compositions, processes for their preparation and methods of use thereof are described. An exemplary composition is a solid oral pharmaceutical composition containing an active agent, a gelling agent in an amount of between about 0.7 and about 1.5% of the weight of the composition, and a channeling agent in an amount of at least about 40% of the weight of ...
Method for the expression of polypeptides using modified nucleic acids
Hoffmann-la Roche Inc.
April 12, 2018 - N°20180100006

Herein is reported a method for recombinantly producing a polypeptide in a cell comprising the step of cultivating a cell which comprises a nucleic acid encoding the polypeptide, and recovering the polypeptide from the cell or the cultivation medium, wherein each of the amino acid residues of the polypeptide is encoded by at least one codon, whereby the different codons ...
Traditional chinese medicine composition and preparation method and use thereof
Infinitus (china) Company Ltd.
March 29, 2018 - N°20180085416

The present invention relates to the field of traditional chinese medicine formulation, particularly to a composition and the preparation method and use thereof. The traditional chinese medicine composition provided by the present invention is produced from raw materials comprising taraxaci herba, glycyrrhizae radix et rhizoma, platycodonis radix, citri reticulatae pericarpiunm and phyllanthi fructus.
Optimized liver-specific expression systems for fviii and fix
Vrije Universiteit Brussel
March 15, 2018 - N°20180071406

The present invention relates to nucleic acid expression cassettes and vectors containing liver-specific regulatory elements and codon-optimized factor ix or factor viii transgenes, methods employing these expression cassettes and vectors and uses thereof. The present invention is particularly useful for applications using liver-directed gene therapy, in particular for the treatment of hemophilia a and b..
Oral dosage forms for oxygen-containing active agents and oxyl-containing polymer
Spriaso Llc
March 15, 2018 - N°20180071277

The disclosed invention is drawn to pharmaceutical tablets that provide delivery of active agents having at least three oxygen-containing groups, a tri-oxy active agent, as well as a second active ingredient. Non-limiting examples of three oxygen-containing group active agents include guaifenesin, codeine, hydrocodone, and their pharmaceutically acceptable salts.
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone, prodrugs, methods of ...
Kempharm, Inc
March 08, 2018 - N°20180065975

The presently described technology provides compositions comprising aryl carboxylic acids and, for example nsaids, chemically conjugated to oxycodone (4,5-α-epoxy-14-hydroxy-17-methylmorphinan-6-one) to form novel prodrugs/compositions of oxycodone, including benzoates, salicylates, propionates, fenamates, and acetates, which have a decreased potential for abuse of oxycodone. The present technology also provides methods of treating patients, pharmaceutical kits and ...
Novel aminoglycosides and uses thereof in the treatment of genetic disorders
Technion Research & Development Foundation Limited
March 08, 2018 - N°20180064743

A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders..
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  • 98+ full patent PDF documents of Codon-related inventions.
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  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Vectors and methods for targeted integration in loci comprising constitutively expressed genes
Murdoch Childrens Research Institute
March 01, 2018 - N°20180057842

The invention relates to a vector comprising: a 5′ nucleic acid that is homologous to a genomic sequence 5′ of a stop codon of a constitutively expressed gene; an exogenous nucleic acid; a 3′ nucleic acid that is homologous to a genomic sequence 3′ of the stop codon of the constitutively expressed gene; a translation interruption-reinitiation signal operably linked to ...
Pharmaceutically acceptable salts and polymorphic forms of hydrocodone benzoic acid enol ester and processes for ...
Kempharm, Inc.
March 01, 2018 - N°20180057503

Compositions comprising hydrocodone benzoic acid enol ester to form novel prodrugs including hydrocodone benzoic acid enol ester salts, and various polymorphs. Also provided are processes for the preparation of hydrocodone benzoic acid enol ester salts, and various polymorphs..
Abuse deterrent dosage forms
Banner Life Sciences Llc
March 01, 2018 - N°20180055837

Described herein are oral abuse deterrent pharmaceutical compositions, methods for making the same, and methods for treating pain by administering the pharmaceutical composition to a subject in need thereof. In particular, an oral abuse deterrent pharmaceutical composition comprising a soft capsule and a controlled release matrix comprising oxycodone are described..
Process for the preparation of benzhydrocodone hydrochloride
Noramco, Inc.
March 01, 2018 - N°20180055836

The invention is directed to processes for the preparation of benzhydrocodone hydrochloride. More particularly, the invention is directed to processes for a one-pot synthesis of benzhydrocodone hydrochloride of improved yield and/or purity..
Codon optimization for titer and fidelity improvement
Sutro Biopharma, Inc.
February 22, 2018 - N°20180051065

The invention provides methods for producing a protein in a cell free protein synthesis system such that the protein does not contain an asparagine (asn or n) residue at serine (ser or s) positions. Also provided are compositions and nucleic acid templates for use in the methods described herein..
Abuse-resistant formulations
Cima Labs Inc.
February 22, 2018 - N°20180049974

This disclosure relates to a sustained-release oral dosage form suitable for twice-a-day administration comprising a matrix containing a viscosity modifier and coated granules containing hydrocodone. The dosage form can have a release profile such that 6 hours following administration, less than about 80 percent of the hydrocodone is released.
Codon optimized il-15 and il-15r-alpha genes for expression in mammalian cells
February 15, 2018 - N°20180044392

The present invention further provides expression vectors, and il-15 and il-15 receptor alpha combinations (nucleic acid and protein) that increase il-15 stability and potency in vitro and in vivo. The present methods are useful for the increased bioavailability and biological effects of il-15 after dna, rna or protein administration in a subject (e.g.
Crystalline salts of hydrocodone bitartrate
GrÜnenthal Gmbh
February 15, 2018 - N°20180044347

Crystalline salts of 4,5 α-epoxy-3-methoxy-17-methylmorphinan-6-one tartrate (1:1) (hydrocodone bitartrate) are disclosed and three polymorphic forms of these salts are reported. The invention further relates to a pharmaceutical composition comprising such a salt and such a salt as a medicament and for the treatment and/or prevention of pain..
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