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Codon

Codon-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for gene optimization
Genective, S.a.
August 10, 2017 - N°20170226524

The invention relates to method of modifying a coding sequence encoding a non-plant protein, comprising the steps of optimizing said coding sequence by codon substitution, thereby obtaining an optimized coding sequence which encodes said non-plant protein; and re-introducing at least one wild-type polyadenylation motif sequence at its position within said optimized gene sequence.
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
Baxalta Gmbh
August 10, 2017 - N°20170226188

The present disclosure provides, among other aspects, codon-altered polynucleotides encoding factor viii variants for expression in mammalian cells. In some embodiments, the disclosure also provides mammalian gene therapy vectors and methods for treating hemophilia a.
Solid salt form of alpha-6-mpeg6-o-hydroxycodone as opioid agonists and uses thereof
Nektar Therapeutics
August 10, 2017 - N°20170226119

Solid forms of certain opioid agonists are provided herein. Methods of preparing the solid forms, methods of using the solid forms, and pharmaceutical compositions comprising the solid forms are also provided herein.
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Expression system for modulating an immune response
Admedus Vaccines Pty Ltd.
August 03, 2017 - N°20170218393

The present invention discloses methods and compositions for modulating the quality of an immune response to a target antigen in a mammal, which response results from the expression of a polynucleotide that encodes at least a portion of the target antigen, wherein the quality is modulated by replacing at least one codon of the polynucleotide with a synonymous codon that ...
Treating pain in patients with hepatic impairment
Pernix Ireland Pain Limited
July 20, 2017 - N°20170202831

An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way ...
Novel arenavirus vaccine
The Scripps Research Institute
July 13, 2017 - N°20170196964

The invention relates to compositions and methods for preventing or treating arenavirus related diseases and disorders through the administration to a subject in need thereof a live-attenuated virus (lav), wherein the lav is a codon deoptimized (cd) arenavirus.
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Codon-optimized recombinant plasmid, method of stimulating peripheral nerve regeneration, and method of treating nerve damage ...
''nextgen'' Company Limited
July 06, 2017 - N°20170189488

Provided is a method for treating a peripheral nervous system damage or injury, or for regenerating peripheral nervous system tissue that involves administering to a subject in need thereof a vector that comprises polynucleotide sequences that encode vascular endothelia growth factor (vegf) and fibroblast growth factor (fgf2) and further a polynucleotide that encodes resistance to kanamycin. A gene-therapeutic structure coding ...
High temperature seed germination
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
June 29, 2017 - N°20170183682

The present invention relates to a seed comprising in its genome a modified nxs gene and/or modified regulatory sequences thereof. The modified nxs gene and/or modified regulatory sequences thereof provides the seed with the capability to germinate at a high temperature as compared to a wild type seed not having the modified nxs gene. The modification to the ...
Process for recombinant protein expression augmentation in bacillus expression system
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
June 29, 2017 - N°20170183668

A process for efficient expression of a foreign gene in a bacillus host was developed by varying the length and nucleotide sequence in the spacer region between ribosomal binding sequence (rbs) and initiation codon (atg) of the gene. Bacillus thuringiensis cry2ac gene was selected as a model gene because it requires an upstream open reading frame designated as orf2 ...
Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
Genzyme Corporation
June 29, 2017 - N°20170182189

The present disclosure relates to antisense oligonucleotides (aons) for modulating the expression of glycogen synthase. Aons of the present disclosure may be useful in treating diseases associated with the modulation of the expression of the enzyme glycogen synthase, such as pompe disease. Also provided by the present disclosure are compositions comprising aons, as well as methods of down regulating mrna ...
Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and ...
Mallinckrodt Llc
June 29, 2017 - N°20170182033

The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because ...
Whitening composition and the use thereof
Infinitus (china) Company Ltd
June 22, 2017 - N°20170172183

The present invention discloses a composition having whitening and brightening effect and the use thereof, the composition comprising: 1) osmanthus; 2) olive; and 3) puerariae lobatae radix, platycodonis radix, glycyrrhizae radix et rhizoma, siraitiae fructus and angelicae dahuricae radix. The composition may be applied to food products. Raw materials used in the composition of the present invention are all common food ingredients and ...
Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants
The University Of Chicago
June 15, 2017 - N°20170166652

Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated ...
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For professional research & prior art discovery
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  • 98+ full patent PDF documents of Codon-related inventions.
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Methods and compositions for transgene expression in a herpesvirus vector system
President And Fellows Of Harvard College
June 15, 2017 - N°20170165336

Compositions are provided comprising a replication-competent herpesvirus vector system and/or a herpesvirus vector particle comprising a heterologous recombinant transgene of interest encoding an antigen of interest (e. G., a tumor-associated antigen, a microbial antigen, etc.), wherein the recombinant transgene has been modified to comprise a codon usage signature of a herpesvirus late gene operably linked to an active promoter. ...
Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav
Uniqure Ip B.v.
June 01, 2017 - N°20170152525

The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e. G. Adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation ...
Novel alpha-hydroxy carboxylic acid and derivatives and other gras based prodrugs of oxycodone and uses ...
Uniqure Ip B.v.
June 01, 2017 - N°20170152266

The invention describes pharmaceutical compounds and compositions comprised of a ligand attached to the opioid oxycodone, in a manner that substantially decreases or deters the potential for opioid abuse, addiction, illicit and illegal use, and overdose. When delivered at the proper dosage, the pharmaceutical composition provides therapeutic activity similar to that of the parent active agent.
Methods of manufacturing oral formulations
Purdue Pharma L.p.
June 01, 2017 - N°20170151229

A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.
Breast fibroadenoma susceptibility mutations and use thereof
Purdue Pharma L.p.
May 25, 2017 - N°20170145504

The present disclosure provides a method of assaying susceptibility and/or confirming diagnosis of breast fibroadenomas development in a human subject. Preferably, the method comprises the steps of performing a nucleic acid-based assay to analyze an isolated polynucleotide encoding at least exon 2 of med12 gene from a sample acquired from the human subject; and regarding the human subject with greater ...
Method for producing l-lysine using microorganisms having ability to produce l-lysine
Purdue Pharma L.p.
May 25, 2017 - N°20170145453

The present invention relates to a modified polynucleotide encoding aspartate kinase (ec:2. 7. 2. 4; hereinafter, referred to as lysc), transketolase (ec:2. 2. 1. 1; hereinafter, referred to as tkt) or pyruvate carboxylase (ec:6. 4. 1. 1; hereinafter, referred to as pyc), in which the initiation codon is substituted with atg, a vector including the same, a microorganism transformed with the vector, and a method for producing l-lysine using ...
Vectors with modified initiation codon for the translation of aav-rep78 useful for production of aav
Purdue Pharma L.p.
May 25, 2017 - N°20170145440

The present invention relates nucleic acid constructs for the production of recombinant parvoviral (e. G. Adeno-associated viral) vectors in insect cells, to insect cells comprising such constructs and to methods wherein the cells are used to produce recombinant parvoviral virions. The insect cells preferably comprise a first nucleotide sequence encoding the parvoviral rep proteins whereby the initiation codon for translation ...
Chimeric antigen receptors recognizing cancer-specific tn glycopeptide variants
Purdue Pharma L.p.
May 25, 2017 - N°20170145108

Disclosed are binding proteins, or fragments thereof, that specifically binds to a cancer-specific glycosylation variant of a protein and to a second epitope on the same protein, to a different protein presented on the same cell, or to a different protein presented on a different cell, such as an encoded polypeptide binding to both a cancer cell and an activated ...
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