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Hydrocodone
Nucleic Acid
Acetaminophen
Carboxylic Acid
Benzoic Acid
Genetically
Recombinant
Amino Acid
Nucleotide
Reverse Transcriptase Inhibitors
Reverse Transcriptase Inhibitor
Reverse Transcriptase
Antibodies
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Replication

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Codon patents



      
           
This page is updated frequently with new Codon-related patent applications. Subscribe to the Codon RSS feed to automatically get the update: related Codon RSS feeds. RSS updates for this page: Codon RSS RSS


Date/App# patent app List of recent Codon-related patents
10/09/14
20140303073
 Antisense antiviral compound and method for treating influenza viral infection patent thumbnailAntisense antiviral compound and method for treating influenza viral infection
The present invention relates to antisense antiviral compounds and methods of their use and production in inhibition of growth of viruses of the orthomyxoviridae family and in the treatment of a viral infection. The compounds are particularly useful in the treatment of influenza virus infection in a mammal.
10/02/14
20140296321
 Methods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites patent thumbnailMethods and compositions for manipulating translation of protein isoforms from alternative initiation of start sites
Provided herein are antisense oligonucleotides, compositions comprising antisense oligonucleotides, and methods for the use of antisense oligonucleotides in manipulating translation. Expression of isoforms of proteins expressed from different start codons of the same transcript are inhibited by antisense oligonucleotides, which may also enhance expression of non-target isoforms..
10/02/14
20140296277
 Pharmaceutical preparation containing oxycodone and naloxone patent thumbnailPharmaceutical preparation containing oxycodone and naloxone
The invention concerns a storage stable pharmaceutical preparation comprising oxycodone and naloxone for use in pain therapy, with the active compounds being released from the preparation in a sustained, invariant and independent manner.. .
10/02/14
20140296137
 Methods and compositions for controlling rotifers patent thumbnailMethods and compositions for controlling rotifers
Described herein are compositions and methods for controlling, inhibiting, reducing and/or preventing rotifer growth with antimicrobial peptides. Methods for removing and/or preventing rotifer infestations in algae cultivations by controlling, inhibiting, reducing and/or preventing rotifer growth with an antimicrobial peptide (amp) are further provided.
10/02/14
20140295006
 Herbal composition for treating metastatic breast cancer patent thumbnailHerbal composition for treating metastatic breast cancer
The invention provides a composition comprising a mixture of extracts obtained from atractylodes macrocephala, astragalus membranaceus, taraxacum mongolicum, poria cocos, ligusticum chuanxiong, ligustrum lucidum, codonopsis pilosula, glycyrrhiza uralensis, hedyotis diffusa, pseudostellaria heterophylla, and viola philippica. The present invention further provides a method for treating metastatic breast cancer in a subject in need thereof, comprising: administering to said subject an pharmaceutically effective amount of the composition..
09/25/14
20140288113
 Extended release compositions comprising hydrocodone and acetaminophen for rapid onset and prolonged analgesia that may be administered without regard to food patent thumbnailExtended release compositions comprising hydrocodone and acetaminophen for rapid onset and prolonged analgesia that may be administered without regard to food
The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof..
09/25/14
20140288006
 Ptd-smad7 therapeutics patent thumbnailPtd-smad7 therapeutics
The present technology provides methods and compositions for the treatment of inflammatory and/or tissue damage conditions. In particular, the use of smad7 compositions delivered locally or systemically to a site of inflammation and/or tissue damage is described.
09/25/14
20140287528
 Incorporation of methyl lysine into polypeptides patent thumbnailIncorporation of methyl lysine into polypeptides
The invention relates to a method of making a polypeptide comprising at least one nε-methyl-lysine at a specific site in said polypeptide, said method comprising (a) genetically directing the incorporation of r—nε-methyl-lysine into said polypeptide, wherein r comprises an auxiliary group; and (b) catalysing the removal of r from the polypeptide of (a). In particular the invention relates to such a method wherein genetically directing the incorporation of r—nε-methyl-lysine into said polypeptide comprises arranging for the translation of a rna encoding said polypeptide, wherein said rna comprises an amber codon, and wherein said translation is carried out in the presence of an amber trna charged with r—nε-methyl-lysine..
09/18/14
20140275143
 Compositions comprising an opioid and an additional active pharmaceutical ingredient for rapid onset and extended duration of analgesia that may be administered without regard to food patent thumbnailCompositions comprising an opioid and an additional active pharmaceutical ingredient for rapid onset and extended duration of analgesia that may be administered without regard to food
The present disclosure provides pharmaceutical compositions comprising an opioid and an additional active pharmaceutical ingredient, wherein the composition exhibits gastric retentive properties which are achieved by a combination of a physical property of the composition and release of the opioid, wherein upon administration to a subject, the composition has at least one pharmacokinetic parameter that differs by less than about 30% when the subject is in a fasted state as compared to a fed state. The present disclosure further provides pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval.
09/18/14
20140271840
 Controlled release hydrocodone formulations patent thumbnailControlled release hydrocodone formulations
A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a c12/cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours..
09/18/14
20140271602
Nucleotide-specific recognition sequences for designer tal effectors
The invention relates to methods of altering expression of a genomic locus of interest or specifically targeting a genomic locus of interest in an animal cell, which may involve contacting the genomic locus with a non-naturally occurring or engineered composition that includes a deoxyribonucleic acid (dna) binding polypeptide having a n-terminal capping region, a dna binding domain comprising at least five or more transcription activator-like effector (tale) monomers and at least one or more half-monomers specifically ordered to target the genomic locus of interest, and a c-terminal capping region, wherein the polypeptide includes at least one or more effector domains, and wherein the polypeptide is encoded by and translated from a codon optimized nucleic acid molecule so that the polypeptide preferentially binds to the dna of the genomic locus.. .
09/11/14
20140255343
Dna vaccine, method of inducing the immune response, method of immunisation, antibodies specifically recognising the h5 haemagglutinin of an influenza virus and use of the dna vaccine
The object of the invention is a dna vaccine, method of inducing the immune response, antibodies specifically recognising the haemagglutinin h5 of an influenza virus and application of the dna vaccine. According to the invention, one or two-fold immunisation of hens with dna vaccine containing a cdna encoding the modified h5 haemagglutinin ha protein, i.e.
09/04/14
20140250549
Protein expression systems
The invention is based on an expression enhancer sequence derived from the rna-2 genome segment of a bipartite rna virus, in which a target initiation site in the rna-2 genome segment has been mutated. Deletion of appropriate start codons upstream of the main rna2 translation initiation can greatly increase in foreign protein accumulation without the need for viral replication.
09/04/14
20140248684
Compositions and methods for the production and use of human cholinesterases
In some aspects, the present invention relates to compositions and methods for the production of human cholinesterases. More particularly, it relates to methods for the production of human cholinesterases using transient expression and vectors for producing the same.
08/28/14
20140244228
Codon optimization of a synthetic gene(s) for protein expression
The present disclosure is related to a method of optimization of a nucleotide coding sequence coding for an amino acid sequence, wherein the nucleotide coding sequence is optimized for expression in a host cell. The present disclosure also relates to system for optimizing a nucleotide coding sequence coding for an amino acid sequence, wherein the nucleotide coding sequence is optimized for expression in a host cell..
08/28/14
20140242574
Codon-optimized gene for mutated shrimp luciferase and method for use thereof
There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.
08/14/14
20140228558
Method and device for optimizing a nucelotide sequence for the purpose of expression in a protein
The invention relates to a method for optimizing a nucleotide sequence for expression of a protein on the basis of the amino acid sequence of the protein, in which for a particular region there is specification of a test sequence with m optimization positions on which the codon occupation is varied, a quality function being used to ascertain the optimal codon occupation on these optimization positions, and one or more codons of this optimal occupation being specified as codons of the optimized nucleotide sequence. These steps are iterated, with the codons of the optimized nucleotide sequence which are specified in the preceding steps remaining unchanged in subsequent iteration steps.
08/07/14
20140220661
Live bacterial vaccines for prophylaxis or treatment of infection
A live bacterium, having a dna construct stabilized against transduction of other bacteria, having a promoter sequence and encoding a fusion peptide, comprising a bacterial secretion peptide portion and a non-bacterial immunogenic polypeptide portion, having a nucleotide sequence coding for the non-bacterial immunogenic polypeptide portion which has at least one codon optimized for bacterial expression. The bacterium has a secretion mechanism which interacts with at least the bacterial secretion peptide portion to cause a secretion of the fusion peptide from the bacterium, and a genetic virulence attenuating mutation.
08/07/14
20140220658
Recombinant butyrylcholinesterases and truncates thereof
Isolated nucleic acids encoding polypeptides that exhibit butyrylcholinesterase (bche) enzyme activity are disclosed, along with molecular criteria for preparing such nucleic acids, including codon optimization. Methods of preparing modified and/or truncated bche molecules having selected properties, especially selective formation of monomers, are also described.
07/24/14
20140206871
Low abuk oxycodone, its salts and methods of making same
A method of preparing oxycodone includes forming 14-hydroxycodeine by reduction of 14-hydroxycodeinone and rearrangement of the 14-hydroxycodeine to form the oxycodone. During the reduction step, the ketone group of an undesirable contaminant precursor, 8,14-dihydroxy-7,8-dihydrocodeinone, is reduced to a hydroxyl group thus forming a triol.
07/24/14
20140206637
Inhibition of nonsense mediated mrna decay by drugs that prevent hypusination of eukaryotic initiation factor 5a
Provided are methods for treating a nad comprising administering to a patient suffering from a nad an inhibitor of nmd and a nonsense suppressor, whereby degradation of nmd susceptible mrna is decreased and translation termination at a misplaced nonsense codon is blocked.. .
07/24/14
20140206579
Dna libraries encoding frameworks with synthetic cdr regions
A synthetic dna library or a member of a synthetic dna library of antibodies or fragments of antibody molecules having heavy chain(s) and lacking light chain(s) is described wherein the cdr within variable domains are synthesized using randomly assembled trinucleotide phosphoramidites (trimer phosphoramidites) to eliminate unwanted cysteine amino acids and/or stop codons.. .
07/24/14
20140206070
Vector with codon-optimised genes for an arabinose metabolic pathway for arabinose conversion in yeast for ethanol production
The present invention relates to novel expression cassettes and expression vectors, comprising three nucleic acid sequences for araa, arab and arad, each coding for a polypeptide of an l-arabinose metabolic pathway, in particular, a bacterial l-arabinose metabolic pathway. The invention particularly relates to expression cassettes and expression vectors, comprising codon-optimised nucleic acid sequences for araa, arab and arad.
07/17/14
20140199394
Controlled release hydrocodone
A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.. .
07/03/14
20140186926
Baculoviral vectors comprising repeated coding sequences with differential codon biases
The present invention relates to production of proteins in insect cells whereby repeated coding sequences are used in baculoviral vectors. In particular the invention relates to the production of parvoviral vectors that may be used in gene therapy and to improvements in expression of the viral rep proteins that increase the productivity of parvoviral vectors..
07/03/14
20140186382
Codon-optimized polynucleotide-based vaccines against human cytomegalovirus infection
The invention is related to polynucleotide-based cytomegalovirus vaccines. In particular, the invention is plasmids operably encoding hcmv antigens, in which the naturally-occurring coding regions for the hcmv antigens have been modified for improved translation in human or other mammalian cells through codon optimization.
07/03/14
20140186300
Targeted pre-mrna/mrna modification and gene regulation
Methods for affecting mrna expression or translation through the modification of pre-mrna or mrna transcripts are described. In one embodiment of the methods of the present invention, the branch point adenosine of a pre-mrna transcript is 2′-0-methylated to block splicing and subsequent expression of the protein encoded by the transcript.
06/26/14
20140179729
Oral dosage forms for oxygen-containing active agents and oxyl-containing polymer
The disclosed invention is drawn to pharmaceutical tablets that provide delivery of active agents having at least three oxygen-containing groups, as well as a second active ingredient. Non-limiting examples of three oxygen-containing group active agents include guaifenesin, codeine, hydrocodone, and their pharmaceutically acceptable salts.
06/26/14
20140179728
Oral dosage forms for oxygen-containing active agents and oxyl-containing polymer
The disclosed invention is drawn to pharmaceutical tablets that provide delivery of active agents having at least three oxygen-containing groups, as well as a second active ingredient. Non-limiting examples of three oxygen-containing group active agents include guaifenesin, codeine, hydrocodone, and their pharmaceutically acceptable salts.
06/26/14
20140179538
Mutations in pancreatic neoplasms
To help reveal the pathogenesis of these lesions, we purified the dna from intraductal papillary mucinous neoplasm (ipmn) cyst fluids from 19 patients and searched for mutations in 169 genes commonly altered in human cancers. We identified recurrent mutations at codon 201 of gnas.
06/26/14
20140179004
Cell for use in immunotherapy which contains modified nucleic acid construct encoding wilms tumor gene product or fragment thereof, method for producing said cell, and said nucleic acid construct
A cell of the present invention contains a nucleic acid construct encoding a wt1 gene product or a fragment of the wt1 gene product. The nucleic acid construct contains (i) a region encoding a desired fragment of the wt1 gene product and (ii) only aug as a functional start codon.
06/19/14
20140171620
Ciliary neurotrophic factor variants
Nucleic acid molecule selected from the group consisting of (a) a nucleic acid molecule having a nucleotide sequence shown in seq id: no 1, (b) a nucleic acid molecule which encodes a peptide having an amino acid sequence shown in seq id: no 2, (c) a nucleic acid molecule whose complementary strand hybridizes to a nucleic acid molecule according to (a) or (b) and which codes for a peptide which binds to ciliary neurotrophic factor receptor (cntfr), the peptide binding with lower affinity than ciliary neurotrophic factor to the interleukin-6 receptor (il-6r), (d) a nucleic acid molecule whose nucleotide sequence differs from the nucleotide sequence of a nucleic acid molecule according to (c) due to the degenerated genetic code, the codon at positions 82-84 of the nucleic acid molecule according to (a) coding for a non-positively charged amino acid, and the peptide at position 28 shown in seq id: no 2 having a non-positively charged amino acid residue.. .
06/19/14
20140170217
Combination composition comprising oxycodone and acetaminophen for rapid onset and extended duration of analgesia
The present disclosure provides an extended release pharmaceutical composition comprising oxycodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof..
06/12/14
20140162935
Compositions comprising enzyme-cleavable oxycodone prodrug
The embodiments provide compound kc-8, n-1-[3-(oxycodone-6-enol-carbonyl-methyl-amino)-2,2-dimethyl-propylamine]-arginine-glycine-malonic acid, or acceptable salts, solvates, and hydrates thereof. The present disclosure also provides compositions, and their methods of use, where the compositions comprise a prodrug, compound kc-8, that provides controlled release of oxycodone.
06/12/14
20140161879
Treating pain in patients with hepatic impairment
An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition comprises a multiparticulate modified release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules as the primary package.
06/05/14
20140154744
Compositions and methods for making selenocysteine containing polypeptides
Non-naturally occurring trnasec and methods of using them for recombinant expression of proteins engineered to include one or more selenocysteine residues are disclosed. The non-naturally occurring trnasec can be used for recombinant manufacture of selenocysteine containing polypeptides encoded by mrna without the requirement of an secis element.
05/29/14
20140147459
Computationally optimized broadly reactive antigens for h1n1 influenza
Described herein is the generation of optimized h1n1 influenza ha polypeptides for eliciting a broadly reactive immune response to h1n1 influenza virus isolates. The optimized ha polypeptides were developed through a series of ha protein alignments, and subsequent generation of consensus sequences, based on selected h1n1 viruses isolated from 1918-2012.
05/22/14
20140141090
Pharmaceutical composition comprising opioid agonist and sequestered antagonist
This invention pertains to pharmaceutical composition comprising a plurality of multi-layered beads having an oxycodone layer and a sequestering subunit comprising a naltrexone and a blocking agent, in particular pharmaceutical compositions comprising a higher level of naltrexone, and related compositions and methods of use, such as in the prevention of abuse of a therapeutic agent. The compositions of the present invention also have a long tmax for oxycodone release and a flatter release profile of oxycodone over time..
05/08/14
20140127248
Computationally optimized broadly reactive antigens for h1n1 influenza
Described herein is the generation of optimized h1n1 influenza ha polypeptides for eliciting a broadly reactive immune response to h1n1 influenza virus isolates. The optimized ha polypeptides were developed through a series of ha protein alignments, and subsequent generation of consensus sequences, based on selected h1n1 viruses isolated from 1918-2011.
05/01/14
20140121124
Compositions and methods for the identification of inhibitors of retroviral infection
Methods of identifying inhibitors of retroviral propagation, trna used in the methods, and kits, including the trna, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed.
05/01/14
20140120061
Abuse resistant melt extruded formulation having reduced alcohol interaction
The present invention relates to compositions for oral administration. The invention preferably comprises at least one abuse-resistant drug delivery composition for delivering a drug having potential for dose dumping in alcohol, related methods of preparing these dosage forms, and methods of treating a patient in need thereof comprising administering the inventive compositions to the patient.
04/24/14
20140112981
Controlled release hydrocodone formulations
A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a c12/cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours..


Popular terms: [SEARCH]

Codon topics: Hydrocodone, Nucleic Acid, Acetaminophen, Carboxylic Acid, Benzoic Acid, Genetically, Recombinant, Amino Acid, Nucleotide, Reverse Transcriptase Inhibitors, Reverse Transcriptase Inhibitor, Reverse Transcriptase, Antibodies, Base Sequence, Replication

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This listing is a sample listing of patent applications related to Codon for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Codon with additional patents listed. Browse our RSS directory or Search for other possible listings.
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