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Codon

Codon-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Genetically expanded cell free protein synthesis systems, methods and kits
B.g Negev Technologies And Applications Ltd., At Ben-gurion University
October 12, 2017 - N°20170292139

This invention relates to methods of producing a rare amino acid- or non-natural amino acid-containing protein in a cell free protein synthesis system and kits for use in and for accomplishing same. Specifically, the methods comprise the steps of expressing at least one orthogonal suppressor trna (o-trna)/aminoacyl-trna synthetase (aars) pair or derivatives thereof specific for incorporation of a rare ...
Tissue preferential codon modified expression cassettes, vectors containing same, and uses thereof
The Trustees Of The University Of Pennsylvania
October 12, 2017 - N°20170292132

Described herein are synonymously altered gene sequences which express protein in differing levels within secretory as compared to non-secretory target tissue. An expression cassette comprising an open reading frame (orf) for a protein under the control of regulatory sequences which direct expression of the product in cell, which orf has been modified to preferentially increase expression levels in a selected ...
Engineered invariant natural killer t (inkt) cells and methods of making and using thereof
The Regents Of The University Of California
October 05, 2017 - N°20170283481

Disclosed are invariant natural killer t (inkt) cells engineered using hematopoietic stem and progenitor cells (hspcs) and methods of making and using thereof. Specifically, the engineered cells inkt are genetically modified to contain at least one exogenous invariant natural killer t cell receptor (inkt tcr) nucleic acid molecule. Further disclosed are inkt tcr nucleotide sequences and codon optimized sequences for ...
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Optimized factor ix gene
Biogen Ma Inc.
September 14, 2017 - N°20170260516

The present invention provides codon optimized factor ix sequences, vectors and host cells comprising codon optimized factor ix sequences, polypeptides encoded by codon optimized factor ix sequences, and methods of producing such polypeptides. The present invention also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized factor ix nucleic acid sequence or ...
Compositions and methods to treat aids
University Of Massachusetts
September 14, 2017 - N°20170258892

Polyvalent, primary isolate nucleic acid compositions for inducing an immune response against hiv are disclosed. The compositions and methods described herein are for the use of a nucleic acid composition that encodes one or more different hiv envelope glycoproteins. The synthetic, codon-optimized dnas encoding one or more hiv proteins are a combination of different nucleic acids, such as dna plasmids, ...
Multivalent brucella vaccine for protection against mycobacterial infections and methods of using the same
Virginia Tech Intellectual Properties, Inc.
August 31, 2017 - N°20170246282

Provided herein is a multivalent brucella vaccine expressing at least one heterologous m. Tuberculosis antigen. The vaccines described herein serve as an environmentally safe bivalent vaccine for protection against brucella and mycobacterium infections simultaneously. In particular, a multivalent vaccine comprising a brucella strain transformed with a vector that expresses at least one m. Tuberculosis antigen, where the m. Tuberculosis antigen(...
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Codon Patent Applications
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  • 98+ full patent PDF documents of Codon-related inventions.
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Adeno-associated virus vectors for treatment of glycogen storage disease
The U.s.a., As Represented By The Secretary, Department Of Health And Human Services
August 17, 2017 - N°20170233763

The present disclosure describes improved adeno-associated virus (aav) vectors for gene therapy applications in the treatment of glycogen storage disease, particularly glycogen storage disease type ia (gsd-ia). Described are recombinant nucleic acid molecules, vectors and recombinant aav that include a g6pc promoter/enhancer, a synthetic intron, a g6pc coding sequence (such as a wild-type or codon-optimized g6pc ...
Site-specific incorporation of phosphoserine into proteins in escherichia coli
Yale University
August 17, 2017 - N°20170233749

Nucleic acids encoding mutant elongation factor proteins (ef-sep), phosphoseryl-trna synthetase (seprs), and phosphoseryl-trna (trnasep) and methods of use in site specific incorporation of phosphoserine into a protein or polypeptide are described. Typically, seprs preferentially aminoacrylates trnasep with o-phosphoserine and the trnasep recognizes at least one codon such as a stop codon. Due to the negative charge of the phosphoserine, sep-trnasep ...
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
Baxalta Gmbh
August 17, 2017 - N°20170233455

The present disclosure provides, among other aspects, codon-altered polynucleotides encoding factor viii variants for expression in mammalian cells. In some embodiments, the disclosure also provides mammalian gene therapy vectors and methods for treating hemophilia a.
Method for gene optimization
Genective, S.a.
August 10, 2017 - N°20170226524

The invention relates to method of modifying a coding sequence encoding a non-plant protein, comprising the steps of optimizing said coding sequence by codon substitution, thereby obtaining an optimized coding sequence which encodes said non-plant protein; and re-introducing at least one wild-type polyadenylation motif sequence at its position within said optimized gene sequence.
Viral vectors encoding recombinant fviii variants with increased expression for gene therapy of hemophilia a
Baxalta Gmbh
August 10, 2017 - N°20170226188

The present disclosure provides, among other aspects, codon-altered polynucleotides encoding factor viii variants for expression in mammalian cells. In some embodiments, the disclosure also provides mammalian gene therapy vectors and methods for treating hemophilia a.
Solid salt form of alpha-6-mpeg6-o-hydroxycodone as opioid agonists and uses thereof
Nektar Therapeutics
August 10, 2017 - N°20170226119

Solid forms of certain opioid agonists are provided herein. Methods of preparing the solid forms, methods of using the solid forms, and pharmaceutical compositions comprising the solid forms are also provided herein.
Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of ...
Kempharm, Inc.
August 10, 2017 - N°20170226118

The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present ...
Codon Patent Pack
Download 98+ patent application PDFs
Codon Patent Applications
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For professional research & prior art discovery
inventor
  • 98+ full patent PDF documents of Codon-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Treating pain in patients with hepatic impairment
Pernix Ireland Pain Limited
July 20, 2017 - N°20170202831

An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules. The composition is designed to release hydrocodone in a way ...
Novel arenavirus vaccine
The Scripps Research Institute
July 13, 2017 - N°20170196964

The invention relates to compositions and methods for preventing or treating arenavirus related diseases and disorders through the administration to a subject in need thereof a live-attenuated virus (lav), wherein the lav is a codon deoptimized (cd) arenavirus.
Sv82 polypeptide, and cosmetic composition for reducing skin wrinkles and maintaining skin elasticity comprising sv82 ...
Nexgen Biotechnologies, Inc.
July 06, 2017 - N°20170190747

A spider venom (sv) 82 polypeptide has an amino acid sequence of seq id no: 2. An sv82 polypeptide-encoding gene having a nucleotide sequence of seq id no: 1 which is optimized for e. Coli codon. A recombinant vector includes the sv82 polypeptide-encoding gene, an e. Coli is transformed with the recombinant vector. A method of producing sv82 polypeptide includes transforming a host ...
Codon-optimized recombinant plasmid, method of stimulating peripheral nerve regeneration, and method of treating nerve damage ...
''nextgen'' Company Limited
July 06, 2017 - N°20170189488

Provided is a method for treating a peripheral nervous system damage or injury, or for regenerating peripheral nervous system tissue that involves administering to a subject in need thereof a vector that comprises polynucleotide sequences that encode vascular endothelia growth factor (vegf) and fibroblast growth factor (fgf2) and further a polynucleotide that encodes resistance to kanamycin. A gene-therapeutic structure coding ...
High temperature seed germination
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
June 29, 2017 - N°20170183682

The present invention relates to a seed comprising in its genome a modified nxs gene and/or modified regulatory sequences thereof. The modified nxs gene and/or modified regulatory sequences thereof provides the seed with the capability to germinate at a high temperature as compared to a wild type seed not having the modified nxs gene. The modification to the ...
Process for recombinant protein expression augmentation in bacillus expression system
Rijk Zwaan Zaadteelt En Zaadhandel B.v.
June 29, 2017 - N°20170183668

A process for efficient expression of a foreign gene in a bacillus host was developed by varying the length and nucleotide sequence in the spacer region between ribosomal binding sequence (rbs) and initiation codon (atg) of the gene. Bacillus thuringiensis cry2ac gene was selected as a model gene because it requires an upstream open reading frame designated as orf2 ...
Inhibiting or downregulating glycogen synthase by creating premature stop codons using antisense oligonucleotides
Genzyme Corporation
June 29, 2017 - N°20170182189

The present disclosure relates to antisense oligonucleotides (aons) for modulating the expression of glycogen synthase. Aons of the present disclosure may be useful in treating diseases associated with the modulation of the expression of the enzyme glycogen synthase, such as pompe disease. Also provided by the present disclosure are compositions comprising aons, as well as methods of down regulating mrna ...
Pharmaceutical compositions for extended release of oxycodone and acetaminophen resulting in a quick onset and ...
Mallinckrodt Llc
June 29, 2017 - N°20170182033

The present disclosure provides extended release pharmaceutical compositions comprising oxycodone and acetaminophen that produce a quick initial onset of analgesia, yet, maintain analgesia for about 12 hours after administration of the composition to a subject in need thereof. The pharmaceutical compositions disclosed herein also reduce the levels of acetaminophen in a subject's blood near the end of the dosing interval because ...
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