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Hydrocodone
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Codon patents



      
           
This page is updated frequently with new Codon-related patent applications. Subscribe to the Codon RSS feed to automatically get the update: related Codon RSS feeds. RSS updates for this page: Codon RSS RSS


Date/App# patent app List of recent Codon-related patents
04/23/15
20150110870
 Controlled release hydrocodone formulations patent thumbnailnew patent Controlled release hydrocodone formulations
A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.. .
Purdue Pharma L.p.
04/16/15
20150105537
 Codon optimized sequence for an antiviral protein patent thumbnailCodon optimized sequence for an antiviral protein
A codon optimized nucleic acid sequence for interferon alpha-2a is provided which can be used for expression of interferon alpha-2a in e. Coli..
Biogenomics Limited
04/09/15
20150099798
 Variants of yeast ndi1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction patent thumbnailVariants of yeast ndi1 gene, and uses thereof in the treatment of disease associated with mitochondrial dysfunction
An isolated nucleic acid sequence encoding the yeast ndi1 protein of seq id no: 542 or a functional variant thereof is described. The nucleic acid sequence comprises at least 50 codons which are codon optimised compared with the sequence of yeast ndi1 gene of seq id no: 1..
Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin
04/09/15
20150099281
 Method for producing l-lysine using microorganisms having ability to produce l-lysine patent thumbnailMethod for producing l-lysine using microorganisms having ability to produce l-lysine
The present invention relates to a modified polynucleotide encoding aspartate kinase (ec:2.7.2.4; hereinafter, referred to as lysc), transketolase (ec:2.2.1.1; hereinafter, referred to as tkt) or pyruvate carboxylase (ec:6.4.1.1; hereinafter, referred to as pyc), in which the initiation codon is substituted with atg, a vector including the same, a microorganism transformed with the vector, and a method for producing l-lysine using the same.. .
Cj Cheiljedang Corporation
04/02/15
20150094231
 Oligonucleotides and methods for detecting kras and pik3ca mutations patent thumbnailOligonucleotides and methods for detecting kras and pik3ca mutations
Provided are oligonucleotides that are capable of detecting kras and pik3ca mutations in both cancer patients and healthy individuals with high specificity in kpcr assays. When the oligonucleotides are used as forward primers in conjunction with a defined genotyping algorithm spreadsheet, the primers are capable of enhancing detection of kras codon 12, 13, and 61 and pik3ca codon 542, 545, and 1047 single nucleotide polymorphisms (snps) in a background of wild-type sequences.
Siemens Healthcare Diagnostics Inc.
03/26/15
20150087667
 Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof patent thumbnailBenzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology..
Kempharm, Inc.
03/26/15
20150087666
 Oral dosage forms for oxygen containing active agents and oxyl-containing polymers patent thumbnailOral dosage forms for oxygen containing active agents and oxyl-containing polymers
The disclosed invention is drawn to pharmaceutical tablets that provide delivery of active agents having at least three oxygen-containing groups, a tri-oxy active agent, as well as a second active ingredient. Non-limiting examples of three oxygen-containing group active agents include guaifenesin, codeine, hydrocodone, and their pharmaceutically acceptable salts.
03/26/15
20150086658
 Herbal composition for treating metastatic breast cancer patent thumbnailHerbal composition for treating metastatic breast cancer
The invention provides a composition comprising a mixture of extracts obtained from atractylodes macrocephala, astragalus membranaceus, taraxacum mongolicum, poria cocos, ligusticum chuanxiong, ligustrum lucidum, codonopsis pilosula, glycyrrhiza uralensis, hedyotis diffusa, pseudostellaria heterophylla, and viola philippica. The present invention further provides a method for treating metastatic breast cancer in a subject in need thereof, comprising: administering to said subject an pharmaceutically effective amount of the composition..
03/19/15
20150082496
 Rice gene, gs3, exerting primary control over grain length and grain weight patent thumbnailRice gene, gs3, exerting primary control over grain length and grain weight
The present invention relates to an isolated major gene gs3 which regulates grain weight and grain length in the rice and the cloning of said gene. The dna sequence of gs3 gene is as shown in seq id no.
Huazhong Agricultural University
03/19/15
20150080423
 Pharmaceutical combinations of hydrocodone and naltrexone patent thumbnailPharmaceutical combinations of hydrocodone and naltrexone
Disclosed is a pharmaceutical composition comprising from about 5 to about 20 mg of hydrocodone or a pharmaceutically acceptable salt thereof and from 0.055 to about 0.56 mg naltrexone or pharmaceutically acceptable salt thereof.. .
Purdue Pharma L.p.
03/19/15
20150079630

Cyclic rna and protein production method


The present invention provides a cyclic rna preferable for carrying out rotary protein translation in which translation domains other than that of the target protein are sufficiently short and translation efficiency is high, and a method for producing protein that uses this cyclic rna as template. More specifically, the present invention provides a cyclic rna that encodes a protein, has a full-length number of bases that is equal to or greater than 102 and is a multiple of 3, has at least one start codon, does not have a stop codon in the same reading frame as the start codon, and does not contain an internal ribosome entry site (ires).
Riken
03/19/15
20150079128

Chinese medicinal formulation for treating inflammatory bowel disease and the preparation thereof


This invention relates to a chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of radix codonopsis (dangshen), rhizoma atractylodis macrocephalae (bai zhu), sclerotium poriae cocos (fu ling), rhizoma zingiberis officinalis (gan jiang), radix paeoniae alba (bai shao) and rhizoma coptidis (huanglian)..
Hong Kong Baptist University
03/12/15
20150071995

Abuse resistant forms of extended release hydrocodone, use and making


An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (gi) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided..
Inspirion Delivery Technologies, Llc
03/05/15
20150065536

Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and uses thereof


The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology..
Kempharm, Inc.
03/05/15
20150064247

Abuse resistant forms of immediate release hydrocodone, use and making


An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (gi) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided..
Inspirion Delivery Technologies, Llc
02/26/15
20150056654

Process for the purification of recombinant albumin


A process is provided for the preparation of a highly pure albumin solution the process comprising subjecting albumin (preferably expressed and secreted by transformed yeast) to a series of chromatographic steps. Preferably, the process comprises the steps of positive mode cation exchange chromatography, positive mode anion exchange chromatography, positive mode affinity chromatography, negative mode affinity chromatography (preferably using immobilised aminophenylboronic acid), negative mode cation exchange chromatography, and negative or positive mode anion exchange chromatography.
Novozymes Biopharma Dk A/s
02/26/15
20150056230

Equine encephalitis virus vaccines and methods of using thereof


Disclosed herein are nucleotide sequences which encode a plurality of structural proteins, except the capsid, of an equine encephalitis virus, wherein the nucleotide sequence is codon-optimized for mammalian expression. The nucleotide sequences are codon-optimized for expression in humans.
02/19/15
20150051251

Premature-termination-codons readthrough compounds


Premature termination codons readthrough compounds, composition thereof, and methods of making and using the same are provided.. .
The Regents Of The University Of California
02/19/15
20150050339

Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, making and use thereof


The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology..
Kempharm, Inc.
02/12/15
20150045383

Treating pain in patients with hepatic impairment


An extended release composition for an analgesic active pharmaceutical ingredient which may be an opioid, preferably hydrocodone as the only active ingredient. The extended release composition preferably comprises a extended release composition which may be in the form of beads contained in an oral dosage form such as gelatin capsules.
Zogenix, Inc.
02/12/15
20150044282

Abuse resistant forms of immediate release oxycodone, use and making


An abuse resistant oral pharmaceutical composition, comprising: a barrier layer, comprising a first polymer; a diffusion layer, comprising a second polymer, substantially covering the barrier layer, wherein the diffusion layer is bonded to the barrier layer and comprises a drug that is substantially homogeneously distributed within the second polymer and diffuses from the diffusion layer within the gastrointestinal (gi) tract; and optionally an expansion layer comprising an expandable polymer, wherein the expansion layer is substantially covered by the barrier layer. Methods of making the same and methods of using the same are also provided..
Inspirion Delivery Technologies, Llc
02/12/15
20150044247

Computationally optimized broadly reactive antigens for h3n2, h2n2, and b influenza viruses


Described herein is the generation of optimized h3n2, h2n2 and b influenza ha polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized ha polypeptides were developed through a series of ha protein alignments, and subsequent generation of consensus sequences, based on h3n2, h2n2 and b influenza isolates.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
02/05/15
20150037409

Controlled release hydrocodone formulations


A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.. .
Purdue Pharma L.p.
01/22/15
20150026834

Anastasis biosensor


The present invention relates to the field of anastasis, i.e., the process of reversal of apoptosis. More specifically, the present invention provides methods and compositions useful for studying anastasis.
The Johns Kopkins University
01/22/15
20150025044

Identification and use of compounds that affect the fidelity of eukaryotic translation initiation codon selection


A screening method for identifying compounds that alter the fidelity with which the initiation codon in mrnas is recognized by the translational apparatus in eukaryotes is disclosed. This screening method was used to identify compounds having such activity.
The Johns Hopkins University
01/22/15
20150024438

Heterologous expression of termite cellulases in yeast


The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast saccharomyces cerevisiae.
Mascoma Corporation
01/15/15
20150017196

Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses


Described herein is the generation of optimized h5n1 and h1n1 influenza ha polypeptides for eliciting a broadly reactive immune response to influenza virus isolates. The optimized ha polypeptides were developed through a series of ha protein alignments, and subsequent generation of consensus sequences, based on h5n1 and h1n1 influenza isolates.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
01/08/15
20150010945

Methods and systems for tracking bioremediation processes


A method for expression of engineered constructs containing sequences coding for functional genes of interest in e. Coli strains.
Arizona State Board Of Regents For And On Behalf Of Arizona State University
01/01/15
20150005249

Readthrough inducing agent and drug for treating genetic disease caused by nonsense mutation


A readthrough inducing agent for inducing readthrough of a premature stop codon generated by nonsense mutations, the readthrough inducing agent comprising a compound having a structure expressed by the following structural formula (a), and a drug for treating a genetic disease caused by nonsense mutations, the drug comprising the readthrough inducing agent.. .
University Of Tokyo
12/25/14
20140378498

Tamper resistant composition comprising hydrocodone and acetaminophen for rapid onset and extended duration of analgesia


The present disclosure provides an extended release pharmaceutical composition comprising hydrocodone and acetaminophen that provides a rapid onset of analgesia, and reduced levels of acetaminophen near the end of the dosing interval. Also provided are methods for reducing the risk of acetaminophen-induced hepatic damage in a subject being treated with an acetaminophen containing composition, as well as methods for treating pain in a subject in need thereof..
Mallinckrodt Llc
12/25/14
20140378496

Opioid analgesics and 3-hydroxyacetanilide for treating pain


Pharmaceutical combinations of opioid analgesics and analgesics that act through non-opioid mechanisms are commonly used to provide pain relief. An example of this pharmaceutical combination is the product vicodin™, where the opioid analgesic is hydrocodone and the non-opioid is acetaminophen.
Slx Pharmaceuticals, Llc
12/25/14
20140377800

Method for achieving improved polypeptide expression


The present invention relates to methods of optimization of a protein coding sequences for expression in a given host cell. The methods apply genetic algorithms to optimise single codon fitness and/or codon pair fitness sequences coding for a predetermined amino acid sequence.
Dsm Ip Assets B.v.
12/25/14
20140377349

Controlled release oral dosage form comprising oxycodone


The present invention relates to a controlled-release oral dosage form for administration of oxycodone once a day and a method of preparing a controlled-release oral dosage form for administration of oxycodone once a day.. .
Develco Pharma Schweiz Ag
12/25/14
20140377348

Controlled release hydrocodone formulations


A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a c12/cmax ratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours..
Purdue Pharma L.p.
12/18/14
20140371132

Codon signature for neuromyelitis optica


The present invention provides for the diagnosis and prediction of neuromyelitis optica (nmo) in subject utilizing a unique a codon signature in b cells that has now been associated with nmo and not with any other autoimmune disease. More particularly, the method may comprise the steps of (a) providing a 10 b-cell containing sample from a subject, or dna or rna isolated therefrom; (b) determining the vh1 and/or vh4 structure of vh1nh4-expressing b-cells from said subject, (c) determining the mutational frequency vh1 and/or vh4 genes; (d) identifying the presence or absence of a codon signature associated with nmo or risk of nmo; and (e) selecting patients exhibiting said codon signature..
The Board Of Regents Of The University Of Texas System
12/18/14
20140370545

Reengineering mrna primary structure for enhanced protein production


Described herein are rules to modify natural mrnas or to engineer synthetic mrnas to increase their translation efficiencies. These rules describe modifications to mrna coding and 3′ utr sequences intended to enhance protein synthesis by: 1) decreasing ribosomal diversion via aug or non-canonical initiation codons in coding sequences, and/or 2) by evading mirna-mediated down-regulation by eliminating one or more mirna binding sites in coding sequences..
The Scripps Research Institute
12/04/14
20140357531

Method for producing a nucleic acid library having at least two adjacent variable codon triplets


The invention relates to a method for producing a dna sequence for a nucleic acid library having a plurality of elements. The synthesized dna sequence comprises at least three sections.
12/04/14
20140356962

Novel attenuated poliovirus: pv-1 mono-cre-x


A novel and stable attenuated poliovirus is produced by engineering an indigenous replication element (cre), into the 5′ non-translated genomic region (with inactivation of the native ere element located in the coding region of 2c (mono-crepv), and replacing the nucleic acid sequence of all or part of the capsid coding region (pi) with a substitute pi coding region having reduced codon pair bias. The stably attenuated poliovirus is effective for vaccines and immunization..
12/04/14
20140356390

Modulation of replicative fitness by deoptimization of synonymous codons


Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen.
11/27/14
20140350089

Optimized messenger rna


The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons..
11/20/14
20140343009

Methods for treating methylmalonic acidemia


Methods for treating methylmalonic acidemia in which at least one allele of a gene associated with mma (e.g., the mut, mmaa, or mmab gene) contains a mutation (e.g., nonsense mutation) that results in a premature stop codon in rna encoded by an allele of the gene associated with mma involving the administration of a compound that promotes readthrough of rna (e.g., messenger rna) containing a premature stop codon encoded by an allele of the gene associated with mma are described. The compound can be administered as a single-agent therapy or in combination with one or more additional therapies to a human in need of such treatment..
11/20/14
20140342451

Methods of incorporating amino acid analogs into proteins


The invention provides a method of incorporating nonstandard amino acids into a protein by utilizing a modified aminoacyl-trna synthetase to charge the nonstandard amino acid to a modified trna, which forms strict watson-crick base-pairing with a codon that normally forms wobble base-pairing with natural trnas.. .


Popular terms: [SEARCH]

Codon topics: Hydrocodone, Nucleic Acid, Acetaminophen, Carboxylic Acid, Benzoic Acid, Genetically, Recombinant, Amino Acid, Nucleotide, Reverse Transcriptase Inhibitors, Reverse Transcriptase Inhibitor, Reverse Transcriptase, Antibodies, Base Sequence, Replication

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This listing is a sample listing of patent applications related to Codon for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Codon with additional patents listed. Browse our RSS directory or Search for other possible listings.
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