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Clinical Trial patents



      
           
This page is updated frequently with new Clinical Trial-related patent applications. Subscribe to the Clinical Trial RSS feed to automatically get the update: related Clinical RSS feeds. RSS updates for this page: Clinical Trial RSS RSS


Model systems and treatment regimes for treatment of neurological disease

Nono

Model systems and treatment regimes for treatment of neurological disease

Method for conducting clinical trials based on substantially continuous monitoring of objective quality of life…

Oregon Health & Science University

Method for conducting clinical trials based on substantially continuous monitoring of objective quality of life…

Method for conducting clinical trials based on substantially continuous monitoring of objective quality of life…

Medical research information exchange system


Date/App# patent app List of recent Clinical Trial-related patents
07/30/15
20150213235 
 Systems and methods for profile-integrated clinical trial feasibility assessments patent thumbnailnew patent Systems and methods for profile-integrated clinical trial feasibility assessments
The invention provides tools for generating online feasibility assessments that may be performed live and in which existing profiles of clinical research centers are integrated into the assessment creation process. Tools of the invention allow a planner to create and save new assessment questionnaires, and then to craft the questions in those assessment tools while also provisionally filtering centers, pre-populating assessment data based on center profiles, or both..
Vis Research Inc.


07/23/15
20150202253 
 Model systems and treatment regimes for treatment of neurological disease patent thumbnailModel systems and treatment regimes for treatment of neurological disease
The invention provides animal models and clinical trials for assessing agents for potential use in treating and effecting prophylaxis stroke and other neurological diseases, particularly those mediated at least in part by excitoxitity. The invention also provides preferred dosage and infusion regimes and pharmaceutical compositions for clinical application of such agents..
Nono Inc.


07/09/15
20150193596 
 Method for conducting clinical trials based on substantially continuous monitoring of objective quality of life functions patent thumbnailMethod for conducting clinical trials based on substantially continuous monitoring of objective quality of life functions
A system and method for conducting a clinical trial of a medical treatment of human patients. The system uses an array of sensors in the patient's home for substantially continuously monitoring one or more objective functions of the patient.
Oregon Health & Science University


07/02/15
20150186618 
 Medical research information exchange system patent thumbnailMedical research information exchange system
Systems, methods, and computer-readable media for exchanging medical research information are described. Medical research information may include information associated with a research project (for instance, a clinical trial) and/or the health or physical characteristics of a subject of the research project (“subject information”).

07/02/15
20150182335 
 Left ventricular outflow device (lvode) patent thumbnailLeft ventricular outflow device (lvode)
Hence the concept of lvode: a method to modulate the abnormal dynamic flow obstruction to the aorta. The success of the device will hinge on its clinical trials or outcomes..

06/25/15
20150178873 
 Method and  generating a clinical trial budget patent thumbnailMethod and generating a clinical trial budget
A method for generating a clinical trial budget includes determining a plurality of procedures to be performed during a clinical trial, calculating the likelihood of reimbursement by a third party for each of the procedures, calculating for each of the procedures the expected reimbursement amount, calculating an expected net cost for each of the procedures based on the cost of each procedure and the expected reimbursement amount for each procedure, and summing up the expected net costs of the procedures to determine the clinical trial budget. An apparatus for generating a clinical trial budget is also described and claimed..
Medidata Solutions, Inc.


06/25/15
20150178474 
 System for clinical trial subject compliance patent thumbnailSystem for clinical trial subject compliance
The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol.
Eresearchtechnology, Inc.


06/25/15
20150178473 
 System for clinical trial subject compliance patent thumbnailSystem for clinical trial subject compliance
The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol.
Eresearchtechnology, Inc.


06/25/15
20150178244 
 Method and  determining complexity of a clinical trial patent thumbnailMethod and determining complexity of a clinical trial
A method for determining net complexity of a clinical trial includes determining procedures to be performed during the clinical trial, determining which of the procedures may be routinely performed on clinical trial subjects suffering from the disease that the drug under test is designed to treat, determining the net procedures to be performed for the clinical trial itself, and calculating a complexity score for the net procedures. An apparatus for determining net complexity of a clinical trial is also described and claimed..
Medidata Solutions, Inc.


06/25/15
20150177241 
 Biomarkers of immune response in mucosal lesions and their use with therapeutic vaccination patent thumbnailBiomarkers of immune response in mucosal lesions and their use with therapeutic vaccination
The present invention provides evidence of post-vaccination immunologic changes in target hpv induced cervical intraepithelial neoplasias that suggest the induction of clinically relevant tissue-localized immune responses, despite modest detectable responses in circulating t lymphocytes. The inventive methods allow for identification of immunological responses to hpv immunotherapies, and means for monitoring responses during clinical trials and treatment regimens..
The Johns Hopkins University


06/18/15
20150169670 

Method and system for verification of source data in pharmaceutical studies and other applications


A method and system are described for verifying database entries against corresponding source data collected at a plurality of geographically remote field locations. The invention provides for verification of field data in a manner that is quicker, less labor-intensive and less error-prone as compared with existing methods.

06/18/15
20150168425 

Method and agents to quantify proteins from tissues


As described herein, a robust generalizable method to accurately and sensitively quantitate proteins in tissues and fluids from human patients in a direct manner, not reliant on antibody reagents has been developed. This provides new and robust methods that are useful as biochemical outcome measures in human clinical trials.
Agada Biosciences, Llc


06/11/15
20150161358 

System and performing medical research


There is a system and a method for performing medical research. The method includes receiving a registration record.

06/11/15
20150161336 

Aggregated electronic health record based, massively scalable and dynamically adjustable clinical trial design and enrollment procedure


Adequate patient enrollment and participation in different design stages of a clinical trial is facilitated and scaled by dynamically adjusting clinical trial criteria relative to characteristics and conditions of massive numbers of patients whose medical records have been aggregated in databases in compliance with patient privacy and confidentiality laws and regulations. Patient participation results without intervention by multiple providers of healthcare services, and by directly identifying and communicating with qualified patients while maintaining patient privacy and compliance requirements as required by law..

06/11/15
20150160221 

Biomarkers for breast cancer predictions and diagnoses


The applications of cst4 gene, mrna of cst4, cdna of the splice variants of cst4, the amplicons of the cst4 primers, cystatin s protein coded by cst4 and epitope peptide of cystatin s in the predictions and diagnoses of human breast cancers, is disclosed in this invention. It can be used for the diagnosis and real time monitoring of breast cancers and tumor prognosis predictions.
Suzhou Microdiag Biomedicine Co., Ltd


06/04/15
20150154382 

Clinical trial data capture


A clinical trial data capture system has clinical site computers (6), each registered with a site and having thick client software, and a server (2) programmed to receive clinical data from the site computers and to analyse said data in real time. The server (2) automatically determines if a site computer is outside of an allowed region, indicating unauthorised use, and takes an action such as clearing the computer's data.
Icon Clinical Research Limited


06/04/15
20150154381 

Method and system for sharing access to a database


A computer-implemented method for sharing access to a database of records relating to clinical trial investigators amongst a number of users is disclosed. Each record includes a number of data fields associated with a clinical trial investigator and has associated metadata indicating a record owner.
Drugdev Inc.


06/04/15
20150150941 

Chronic lymphocytic leukemia prognosis and treatment


Provided herein are methods for identifying a subject afflicted with chronic lymphocytic leukemia who is responsive to treatment with a chemotherapeutic agent by detecting the presence or absence of at least one apoe4 allele in the subject, the presence of an apoe4 allele identifying the subject as responsive to the treatment. Also provided are methods of treating a subject afflicted with chronic lymphocytic leukemia, including administering an estrogenic agent, an androgen withdrawal agent, an apoe4 peptide or mimetic thereof, and/or a chemotherapeutic agent in an amount effective to treat said chronic lymphocytic leukemia.
Duke University


06/04/15
20150150928 

Composition for preventing and treating aids and preparation method thereof


The present invention relates to a pharmaceutical composition made from the following raw materials or from water and/or alcohol extracts of the following raw materials in parts by weight: 5 to 200 parts of ganoderma, 5 to 150 parts of radix panacis quinquefolii or radix et rhizoma ginseng, 1 to 90 parts of fermented cordyceps sinensis powder and/or 1 to 120 parts of cordyceps, and optionally one or more of 5 to 90 parts of flos rosae rugosae, 5 to 150 parts of ganoderma spore powder, 10 to 400 parts of radix pseudostellariae, 3 to 400 parts of radix codonopsis and 3 to 400 parts of radix astragali. Clinical trials demonstrate that the composition can significantly reduce hiv virus load in patients, increase the number of cd4+ cells, enhance the immunity of patients, has no considerable toxic and side effects, and is suitable for long-term use..
Jiangzhong Pharmaceutical Co., Ltd.


05/14/15
20150132285 

Proteinase-engineered cancer vaccine induces immune responses to prevent cancer and to systemically kill cancer cells


The present invention provides a method of making a proteinase-engineered cancer vaccine for treating a cancer patient, especially for cancer patient at advanced/metastatic stage. The cancer vaccine comprises dead cancer cells with unbroken plasma membrane wherein the extracellular proteins and extracellular portion of membrane proteins are cleaved by proteinase digestion.

05/07/15
20150125850 

Novel rapid and highly sensitive cell based system for the detection and characterization of hiv


The invention pertains to a novel cell line, an hiv tat-rev dependent gfp-gaussia luciferase reporter cell line, known henceforth as the ggr cell line, that detects pseudotype and replication competent hiv (cloned or uncloned isolates, in cell media or human serum) rapidly and with high sensitivity. This ggr cell line provides an improved method of characterizing the entry phenotype of hiv envelope genes, and detecting and examining primary hiv samples in the context of laboratory research, clinical trial monitoring, and medical diagnostics.
The Regents Of The University Of California


04/23/15
20150110718 

Methods and kits for determining a placebo profile in subjects for clinical trials and for treatment of patients


The present invention is directed to methods and assays for identifying subjects participating in clinical trials that may exhibit a placebo response and identifying treatments for subjects with varying degrees of placebo responses. In one aspect, a method of selecting subjects to participate in a clinical trial is disclosed.
Biometheus Llc


04/16/15
20150106119 

Automated workflow queuing health care


An intelligent routing and automated workflow queuing system for a health care receives information related to health care provider patient treatment assets and individual patient data record information consisting of one or more patient information including urgent medical needs, special accommodation needs, vip status, participation in a research or clinical trial, appointment reason, anticipated amount of health care provider work time needed for this visit, scheduled appointment start time, cumulative wait time in the health care provider setting for this visit as well as other variables. Responsive to this information, the system calculates a quantitative priority variable for each patient and then calculates a quantitative priority variable for each health care provider, for automatically prioritizing and queuing patients for a next care step based on the information related to the health care provider patient treatment assets and individual patient data record information..
Visual Clinic Llc


04/16/15
20150106112 

Systems and methods for multivariate analysis of adverse event data


The present disclosure describes systems and methods for multivarlate analysis of adverse event data. According to a first aspect, patient-specific genomic information is used to optimize or de-risk therapy for the patient.
Molecular Health Ag


04/09/15
20150100339 

Multi-user clinical pathway systems with therapy options and visual notices of clinical trial opportunities


The systems, methods and computer program products provide online access to clinical pathways that provide in a convenient, intuitive and user-friendly manner, treatment options with clinical trial enrollment opportunities as well as a bundled or packaged set of supporting documents and data that can facilitate standardized treatments and provide clinicians with identification of and timely and easy access to open clinical trials.. .
The Charlotte Mecklenburg Hospital Authority D/b/a Carolinas Healthcare System


03/19/15
20150081336 

Electrical computing devices for quantification of differences in medical treatment populations


One disclosed method includes receiving electronic health records (ehrs) associated with a first set of patients for a clinical trial of a health intervention; receiving electronic records representing profiles of patients likely to benefit from the health intervention; determining a first statistic for a first characteristic of the first set of patients and a second statistic for a second characteristic of the patients likely to benefit from the health intervention; and determining a gap in the first set of patients based on the first statistic and the second statistic.. .
Quintiles Transnational Corporation


03/12/15
20150073830 

Electrical computing devices for recruiting a patient population for a clinical trial


One disclosed method includes obtaining an electronic representation of a primary patient population within a first data store, the primary patient population comprising a plurality of electronic health records (ehrs); receiving an electronic representation of a target secondary patient population, the target secondary patient population comprising a target number of patients and at least one characteristic; and generating an electronic representation of the secondary patient population from the primary patient population based on the target number of patients and the at least one characteristic.. .

02/26/15
20150058033 

Systems and methods for pre-qualifying clinical trial populations


Provided are systems and methods for pre-qualification of candidate patient populations. The systems and methods can be are configured for inexpensive, selective, and lightweight procedures that identify patients against desired criteria.
Transparency Life Science, Llc


02/26/15
20150056219 

Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors


Methods and compositions are disclosed to target tumor cells with embodiments of the light proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse receptors with affinity sufficient to conduct preclinical and clinical trials, and with increased affinity as compared to the wild type human light protein.
The University Of Chicago


02/12/15
20150046191 

System and managing genomic information


Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge.
Foundation Medicine, Inc.


02/12/15
20150046187 

Clinical trial participant transportation system


A system and method for connecting a clinical trial participant with a transportation provider. The system, based on information from an authentication mechanism, determines whether an individual requesting desired transportation is an authenticated clinical trial participant having a participant record in a patient recruitment management system database.
Tcn Technologies, Llc


02/12/15
20150046180 

System and managing genomic information


Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. According to one aspect, a graph-based data model is used that may be used to organizes and revise precision medicine knowledge.
Foundation Medicine, Inc.


02/05/15
20150039327 

Systems and methods for managing patient research data


The disclosure is directed to a process and system for managing the end-to-end process of obtaining research data from patients and/or participants in a clinical trial. The process enables collection of appropriate informed consent from patient/participants via electronic devices such as smart phones and tablets.

01/22/15
20150025900 

System and assessing data quality during clinical trials


The present invention relates to a system and methods for facilitating the improvement of data quality generated during drug and medical device clinical trials. In one embodiment, the invention includes a system and method for generating an ideal subject suitability score for one or more interaction points of a clinical trial.

01/22/15
20150023933 

Materials and methods relating to packaging cell lines


Lentiviral packaging cells and methods for producing the same are provided herein. Specifically, lentiviral packaging cells capable of producing lentiviral vector suitable for use in clinical trials are provided.
Ucl Business Plc


01/15/15
20150019251 

Product information management use in clinical trials


A product information management system includes at least one product cabinet in communication with a server. The at least one product cabinet is configured to store one or more product units each configured with a corresponding one or more rfid tags, and monitor an inventory of the one or more product units by wirelessly detecting the one or more rfid tags.
Amerisourcebergen Specialty Group, Inc.


01/15/15
20150019233 

Site-specific clinical trial performance metric system


A computing device can receive site data from a plurality of sites within an industry. The site data can relate to the performance of the sites in at least one measurable metric.
Forte Research Systems, Inc.


12/25/14
20140379362 

Clinical trial participant reimbursement system


A clinical trial participant reimbursement system relies on a separate a patient tracking system having a patient database with a participant record unique identification string for each patient of a plurality of patients configured in such a way that maintains patient anonymity and does not itself convey patient identifying information. The clinical trial participant reimbursement system creates an association between the participant record unique identification string and a reloadable payment card unique identification string for a payment card assigned to each participant for receiving reimbursement payments.
Tcn Technologies, Llc


12/25/14
20140375650 

Systems and methods for data visualization


Systems and methods for data visualization are disclosed. For example, one disclosed method, includes receiving data from a clinical trial, retrieving data relevant to a study indicator (si) from a plurality of data entities, and calculating a plurality of si values, each calculated si value based on the data from one of the plurality of data entities.
Quintiles Transnational Corporation


12/18/14
20140370523 

Methods of determining patient response by measurement of her-2 expression


Methods are provided for determining or otherwise assessing the response of a patient to treatment, in particular, to cancer treatment. The methods include the analysis of samples for the presence or the absence of her2 markers alone or in conjunction with other biomarkers, such as her3 markers.
Laboratory Corporation Of America Holdings


12/18/14
20140370128 

Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria


The present invention relates to a composition comprised of a plant extract as an active component, specifically, bamboo extract and scutellaria extract, for the treatment and prevention of atopic dermatitis. The present invention is a natural ingredient can be obtained from a plant.
Unigen, Inc.


12/04/14
20140353944 

Non-regular electrical stimulation patterns for treating neurological disorders


Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial.

11/27/14
20140350486 

Blinding kit for clinical trials


The present invention relates to a blinding kit for administering a medicament to a patient in a clinical trial, the blinding kit comprising: a first blinding device having an opaque container and having an outlet for administering a liquid substance to a patient and having at least a first and a second inlet, wherein the first inlet is in permanent fluid communication with the outlet and wherein at least the second inlet is disconnected from the outlet, a second blinding device having an opaque container and having an outlet for administering a liquid substance to a patient and having at least two inlets, wherein said at least two inlets are in permanent fluid communication with the outlet.. .

11/27/14
20140350468 

Blinding kit for clinical trials


A blinding device for administering a substance to a patient in a clinical trial is presented where the blinding device has an opaque housing to receive at least two delivery devices adapted to dispense a substance provided therein, an outlet being in fluid communication with at least one delivery device for administering the substance to a patient, and at least one actuating member mechanically engageable with at least one delivery device and being actuatable from outside the housing.. .

11/20/14
20140341983 

Smart™ solid oral dosage forms


Solid oral dosage forms (sodfs) comprising self monitoring and reporting therapeutics (smart™) adherence technology are provided which require no or minimal modification of clinical trial materials (ctms) or marketed drug while providing tamper resistant (literally foolproof) measurement of adherence that is highly accurate and without altering the chemical, manufacturing, and controls (cmc) of the ctm or marketed drug.. .

11/13/14
20140336943 

System and managing genomic testing results


Various embodiments provide interfaces to access genomic testing information and incorporate it into daily physician practice. In some embodiments, presentation of genomic alteration data is simplified and/or coupled with contextual applications.

11/06/14
20140330572 

Framework for modeling a clinical trial study using a cross-over treatment design


The present disclosure provides for modeling a clinical trial study, which may implement a cross-over design. A plurality of treatments is generated for a clinical trial study, based on a first subset of operational parameters.

11/06/14
20140329770 

Compositions comprising phytoestrogens receptor beta agonists and dietary fibers for chemopreventive treatment of sporadic adenomatous polyposis


It is herein discloses compositions comprising a blend of dietary phytoestrogens receptor β agonists and dietary fibers for prevention and treatment of sporadic adenomatous polyposis. The aforementioned compositions proved to be effect in a clinical trial enrolling patients prone to polyp recurrence and at intermediate risk for colorectal cancer (crc) development..

11/06/14
20140328525 

Image based clinical trial assessment


A method for assessing a treatment in a trial includes obtaining images generated from image data acquired at different times during a trial time period for a same region of interest of a subject. The treatment is administered to the subject for the trial.

10/30/14
20140324553 

Computer-assisted adaptive, risk-based monitoring of clinical studies


A computer-assisted method is described for continuously assessing the quality of field data in a clinical study, identifying areas of weakness and specific sites where performance may be less than desirable, and flexibly allocating resources to address the problems, including the need to travel to the site to either check data or address problem areas. This method involves specification of key performance indicators that include elements that, preferentially, can be measured from a central location and do not require physical presence at the site to be checked.

10/23/14
20140316818 

Electronic health records in clinical trials


A method for collecting self-reported data from an individual for use in a clinical trial is provided. The method includes providing a web site allowing the individual to store, organize, and access personal health records associated with the individual and sharing selected personal health records associated with the individual with a clinical trial sponsor.

10/23/14
20140316793 

Systems and methods for recruiting and matching patients for clinical trials


Systems and methods provide for recruiting and matching patients for clinical trials using a network-based software platform which publicizes clinical trials, recruits patients for participation in the clinical trials, and obtains patient profile information to match patients with appropriate clinical trials based on medical and behavioral compatibility. Patients may be recruited to join clinical trials through online networking and referrals using social media and other electronic communication managed by the software platform.

10/23/14
20140316311 

Therapeutic method and apparatus using mechanically induced vibration


A sleeve that provides mechanical stimulation to the arm to prevent bone density loss. A primary goal of this product is to prevent bone density loss that occurs during extended space travel.

10/23/14
20140315294 

Scalable lentiviral vector production system compatible with industrial pharmaceutical applications


The present invention relates to the industrialization of the production of recombinant lentiviral vectors in order to manufacture sufficient materials for therapeutic applications such as gene therapy and/or dna vaccination, for use in clinical trials and/or commercial use.. .

10/16/14
20140310015 

System and process for matching patients with available clinical trials


A system for matching patients to available clinical trials. The process includes a computer with a cpu having a processor, memory and an electronic database.

10/16/14
20140309590 

Needle array assembly and delivering therapeutic agents


A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports.

10/09/14
20140303999 

Method for creating and using registry of clinical trial participants


A method of screening participants for a clinical trial by obtaining a biometric sample from a prospective participant, generating a unique identifier code, populating a database with the unique identifier code and participant information and storing the database on computer readable media, and screening the participant for the clinical trial based on the unique identifier code and participant information. A method of screening participants for a clinical trial by obtaining personal information from a prospective participant, generating a unique identifier code, populating a database with the unique identifier code and participant information and storing the database on computer readable media, and screening the participant for the clinical trial based on the unique identifier code and participant information.

10/02/14
20140297311 

Health care research, management and delivery system


A health care management and delivery system includes a hosted environment that provides health care treatment, diagnosis, and/or management. Health care providers are linked to one another and to a central network, which is linked to patient via the hosted environment.

10/02/14
20140297241 

Reference model for disease progression


A method wherein reference disease models predict progression of disease within given populations, utilizing publically available clinical data and risk equations, to give a birds-eye view of clinical trials by allowing multiple trials to be systematically compared simultaneously via parallel processing/high performance computing which allows competition among alternative equations/hypothesis combinations; cross validation; and, then ranks results according to fitness via a fitness engine.. .

09/25/14
20140289001 

System and recruiting subjects for research studies and clinical trials over the internet


A system and method for managing private records and other confidential information is provided, including a patient interface that allows patients to configure privileges for various parties to access various private records or portions thereof. A database can be accessed via a privacy engine, which respects the configured privileges and allows searching for private records.

09/18/14
20140278469 

Systems and methods for tracking and designing clinical trials


Systems, apparatuses, and methods are provided for planning, activating, analyzing, and monitoring clinical trials. A planning process gathers clinical trial initiation parameters and produces a clinical trial plan.

09/04/14
20140249845 

Clinical trials management system and method


System and method of managing a clinical trial in accordance with a protocol are provided. In accordance therewith, a workflow associated with the protocol is accessed from a first data structure.

09/04/14
20140249835 

Methods and data-driven monitoring


Methods and apparatus for facilitating monitoring in a clinical trial. The method includes acts of receiving data from at least one information technology system configured to process clinical trial data, and assigning a site prioritization to each of a plurality of sites for at least one clinical trial associated with the at least one information technology system.



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