|| List of recent Clinical Trial-related patents
|Idrabiotaparinux for the treatment of pulmonary embolism and for the secondary prevention of venous thromboembolic events|
The invention relates to idrabiotaparinux for use in the treatment of pulmonary embolism in patients with or without deep venous thrombosis and for the secondary prevention of venous thromboembolic events in said patients, wherein the efficacy and safety of said uses are clinically proven by a phase iii clinical trial.. .
|System and method for clinical trial design|
A method of collecting input from individuals comprising searching a database containing a plurality of individual's electronic health records (ehrs), assigning a unique patient key to each individual's ehr and removing the individual's identifying characteristics from the ehr with a computer having a memory and a processor operating a hipaa privacy filter to provide de-identified ehrs, maintaining a confidential record of each individual's identifying characteristics associated with the unique patient key. De-identified ehrs are analyzed to define members of a target group.
|Clinical trials subject identification system|
Matching a subject with a clinical trial includes steps of: collecting patient data associated with the subject; collecting clinical trial data from multiple sources; matching the subject to a clinical trial scheduled in a location accessible to the subject; notifying a health care provider associated with the subject about the clinical trial; and receiving a response.. .
|Methods and reagents for preparing multifunctional probes|
Multifunctional probes are synthesized in a single step using peptide scaffold-based multifunctional single-attachment-point reagents. To obtain multifunctional probes of the invention, a substrate (e.g., a nanoparticle, polymer, antibody, protein, low molecular weight compound, drug, etc.) is reacted with a multifunctional single-attachment-point (msap) reagent.
|Method of equipoise enrollment of subjects in clinical trials|
In a method of enrollment selection of subjects for a clinical trial, a plurality of physician investigators is polled regarding each subject of a plurality of subjects. Responses of the plurality of physician investigators are aggregated for each subject.
|Staff assignment for clinical trials|
Systems, methods, and other embodiments associated with a graphical user interface for scheduling clinical staff are described. In one embodiment, a method includes generating a schedule for a plurality of events.
|Therapeutic methods for solid delivery|
A fluid-delivery device includes an array of needles. The needle can deposit a hollow and/or porous tube into a tissue of a subject, and the porous tube can contain one or more fluid agents.
|System for clinical trial subject compliance|
The present invention is designed to develop research protocols for clinical trials. The invention also can track and enhance subject compliance with a research protocol.
|Freezing medium composition for cryopreserving amniotic fluid-derived stem cells and a method for cryopreserving the same|
Provided are to a freezing medium composition for cryopreserving amniotic fluid-derived stem cells, which has a lower concentration of me2so and eliminates fetal bovine serum and at the same time does not induce cryoinjury to fluid-derived stem cells and makes it possible to cryopreserve fluid-derived stem cells for a prolonged time using trehalose, sucrose and catalase, and a method for cryopreserving the same. According to the present invention, afscs can be cryopreserved with 1/4 the standard me2so concentration with the addition of disaccharides, antioxidants and caspase inhibitors.
|Systems and methods for data integration and standardization|
Systems and methods for data integration and standardization are disclosed. For example, one disclosed method comprises receiving first and second clinical trial data from first and second data stores, transforming the first clinical trial data and the second clinical trial data into operational data formats and storing the transformed data in a second operational data store; generating a first data entity stored in an integrated data format in an integrated data store; selecting a first data record from first clinical trial data in the first operational data format; identifying a second data record from the second clinical trial data in the second operational data format, wherein identifying the second data record is based at least in part on a determined association between the first data record and the second data record; and storing data from the first data record and the second data record in the first data entity..
|Bi-directional biomarker based clinical trial matcher|
A computer-based system configured to organize, analyze, locate and distribute information related to clinical trials is described herein. More particularly, a computer-based system for providing a bi-directional clinical trial matching process (e.g., locate patients based on trial information or locate trials based on patient information) based on biomarkers associated with both a patient and a clinical trial are described herein..
|Design asistance for clinical trial protocols|
Roughly described, a user instantiates protocol elements in a structured clinical trial protocol database and then draws from them in the development of one or more protocol related documents. The system helps the user select tasks to be performed during the study by reference to a historical database of tasks previously associated with similar protocols.
|Method for scaling ophthalmic imaging measurements to reflect functional disability risk|
Methods for relating ophthalmic structural measurements to ophthalmic function are presented. The central idea is that each value for a given structural measurement can be empirically associated with a certain likelihood of disability or reduced function by measuring relevant patient populations in which some subjects have those disabilities this method is intended as an aid to doctors who manage glaucoma, or for the study of glaucoma or glaucoma therapy in clinical trials.
|Automated collection and aggregation of cross-platform and live event or in-person training records to support the conduct of clinical trials|
The invention provides a system and method optimized for clinical trial training management. The inventive system and method collect training records across all training venues and platforms that are internal and external to any organization, provide a simple and efficient means to report on each and every training requirement and the satisfaction of training requirements for each clinical trial staff, and for each clinical trial site; and produce images of any and all certificates or records of attendance pertaining to satisfaction of any training requirement, thereby enabling clinical trial sponsor access to auditable records..
|Clinical trial health care data management|
Health care data is stored in memory accessible to a server. The server allows users to access the health care data, such as across a communication network.
|Method and system for automatically tracking and enforcing compliance and version control of regulatory training for clinical trials|
The invention provides a system that manages version changes of regulatory training and update training plans for those users who are affected by the change based on a set of rules defined by the clinical trial sponsor. The system also provides custom updated training plans when different sponsors have different rules affecting regulatory training updates..
|Stratifying patient populations through characterization of disease-driving signaling|
A method of stratifying a set of disease-exhibiting patients prior to clinical trial of a target therapy begins by using a molecular footprint derived from a knowledgebase and other patient data to identify genes that are differentially expressed in a direction consistent with increase in the target activity. Therapeutic target “signaling strength” in individual patients of the set is then assessed using the genes identified and a strength algorithm.
|Non-regular electrical stimulation patterns for treating neurological disorders|
Systems and methods for stimulation of neurological tissue and generation stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. The features of the stimulation trains may be selected and arranged algorithmically to by clinical trial.
|Methods for facilitating diagnosis, prognosis and treatment of cancer by detecting her1 expression|
Methods are provided for facilitating the diagnosis of subjects with her1-activated cancers. In addition, method of treating subjects with a cancer characterized as having high levels of activated her1 are provided.
|Distribution wide estimated risk scoring to decrease the probability of covariate imbalances adversely affecting randomized trial outcomes|
In certain situations, such as clinical trials, random or semi-random trials may be used to evaluate an outcome of interest. The outcome of such randomized trials may be affected by variables known as “covariates” which, individually or in combination, interact with the underlying subject matter under study.
|Computer system and method for training, certifying or monitoring human clinical raters|
A method and system are disclosed for computerized training, monitoring, certification or re-certification of human raters in clinical trials. The invention provides an interactive computerized interview that can be compared scores obtained by human raters to monitor and train clinical raters on a continuing basis in order to reduce rater drift and variance during clinical trials.
|Systems and methods for drug development|
Systems and methods are provided for drug development under a fully transparent development model. The model is configured to provide transparency to the patients, the researchers, clinicians, physicians, and any other registered users of the system who wish to contribute.
|Method and systsm for accessing patient data|
Data concerning patients that have received treatment by a drug is stored and accessed to it is provided. One or more storage elements are provided that contain data concerning patients that have received the drug.
|System and method for collecting, processing, and storing discrete data records based upon a single data input|
A system and method for the collection, capture, processing, storage, and tracking of data for both electronic clinical trial and electronic heath records based upon a single data collection instance, and including data collected by electronic medical devices. Devices and methods for creating certified digital image copies of original documents, including paper source documents for a clinical trial.
|Systems and methods for de-risking patient treatment|
The present disclosure describes systems and methods for de-risking patient treatment by identifying medications or combinations of medications to be contraindicated for a specific indication. An analyzer executed by a processor of a computing device from a user may receive an identification of an indication (e.g.
|Methods for predicting treatment response based on the expression profiles of biomarker genes in notch mediated cancers|
The invention relates to the identification and use of gene expression profiles, or patterns, with clinical relevance to the treatment of cellular proliferative disorders, especially those mediated by aberrant notch signaling using a notch signaling inhibitor. In particular, the invention provides the identities of genes, whose individual or cumulative expression patterns may be useful in various assays.
|Micelle encapsulation of a combination of therapeutic agents|
The invention provides active agents, such as paclitaxel, rapamycin, or 17-dmag, encapsulated by safe poly(ethylene glycol)-block-poly(lactic acid) (“peg-b-pla”) micelles. The compositions provide effective solubilization of drug combinations, such as paclitaxel, rapamycin, and 17-dmag, as well as others described herein.