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Clinical Trial

Clinical Trial-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and compositions in diagnosis of chronic fatigue syndrome/myalgic encephalomyelitis
The Governors Of The University Of Alberta
January 11, 2018 - N°20180011110

The present disclosure provides methods and compositions that find use in facilitating a diagnosis of chronic fatigue syndrome/myalgic encephalomyelitis (cfs/me) in a subject. The methods and compositions involve measurement of at least one of proteins: il-16, il-7, vegf, cxcl9, cx3cl1, ccl24, ccl19, and ccl11 in a body fluid sample of a subject suspected of having cfs/me. ...
Medical condition management system and methods
January 04, 2018 - N°20180005332

A system ranks pharmaceutical and other regimens for the treatment of chronic diseases (e. G., diabetes) to optimize the patient, medical, financial, and operational aspects of drug therapy using a combination of data impossible for a human to consume and process within any useful period of time. A scoring algorithm balances estimated cost, intolerance, benefit, and efficacy, using information from ...
Electronic data document for use in clinical trial verification system and method
Ikeguchi Holdings, Llc
January 04, 2018 - N°20180004917

The present invention provides an electronic data document (edd) and related system and method for use in a computerized clinical trial verification system. In an exemplary embodiment, the edd is authenticated by the creator and validated by the receiver, and comprises an image of a source document (sd) that comprises a masked record of at least one interaction between a ...
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Transparency tracker
Mms Holdings Inc.
December 14, 2017 - N°20170357778

The clinical trial data management system disclosed herein provides for a transparency tracker with an integrated lifecycle workflow dashboard that navigates clinical trial protocols through disclosure lifecycle stages and workflow modules with scrollable timelines, integrated data screens of supporting information, and integrated document repositories and reporting systems for managing information exchange.
Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
Avanir Pharmaceuticals, Inc.
December 14, 2017 - N°20170354652

During clinical trials on patients suffering from neurological disorders, it has been observed that some patients obtain dramatic improvements in motor control and/or higher mental functioning, when they receive a combination of dextromethorphan and quinidine, at suitable dosages. Improved motor control has been exemplified to date by improved ability to swallow and/or speak, among victims of stroke, head ...
System and method for determining relative operational performance in a clinical trial
Medidata Solutions, Inc.
December 07, 2017 - N°20170351844

A system for determining relative operational performance in a clinical trial may include a processor, a data comparator and visualizer, and a graphical user interface. The processor filters received clinical data into multiple metric criteria to generate multiple metric data sets and filters each metric data set into a respective industry data set and a respective candidate data set. The ...
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Identifying potential patient candidates for clinical trials
International Business Machines Corporation
December 07, 2017 - N°20170351814

A computer system gleans data from patient records and clinical trial descriptions using nlp techniques. Nlp annotation data is used to generate clinical trial feature vectors and patient feature vectors. Clinical trial feature vectors and patient feature vectors are compared to match appropriate patient candidates with clinical trial openings.
Enhancement of impaired motor and mental functions, using dextromethorphan and oxidase enzyme inhibitor
Avanir Pharmaceuticals, Inc.
December 07, 2017 - N°20170348301

During clinical trials on patients suffering from neurological disorders, it has been observed that some patients obtain dramatic improvements in motor control and/or higher mental functioning, when they receive a combination of dextromethorphan and quinidine, at suitable dosages. Improved motor control has been exemplified to date by improved ability to swallow and/or speak, among victims of stroke, head ...
Decision support system for cns drug development
Parexel International Corporation
November 30, 2017 - N°20170340272

A decision support tool for development of drugs targeting central nervous system conditions. The tool receives measurements made on subjects, which are converted to model outputs using neurocircuitry models. The models are used by a computing device to generate neuro-circuitry based signatures. Neuro-circuitry based signatures associated with an investigational compound may be compared to reference neuro-circuitry based signatures to identify ...
Systems and methods for drug development
Transparency Life Science, Llc
November 09, 2017 - N°20170323083

Systems and methods are provided for drug development under a fully transparent development model. The model is configured to provide transparency to the patients, the researchers, clinicians, physicians, and any other registered users of the system who wish to contribute. According to various embodiments, the system and model enable drug development that leverage the combined wisdom and insight of the ...
System and method to produce and validate weighted relations between drug and adverse drug reactions
November 02, 2017 - N°20170316175

A system to produce validated weighted relations between drugs and adverse drug reactions (adrs). At least one processor to monitor social media for links between drugs and adrs; extract a relation between a drug and an adr using named entity recognition to provide a weighted relation between the drug and the adr, the weight based on confidence of the link ...
Method for creating and using registry of clinical trial participants
October 26, 2017 - N°20170308680

A method of screening participants for a clinical trial by obtaining identifying information chosen from a biometric sample, personal information, physical attributes, and combinations thereof from a prospective participant, optionally generating a unique identifier code, populating a database server with the unique identifier code and participant information and storing the information on non-transitory computer readable media, screening the participant for ...
Method for conducting adaptive clinical trial with drug delivery device
October 19, 2017 - N°20170300665

The method set out herein involves conducting adaptive clinical trial to develop parenteral therapeutic product with variable dose drug delivery devices. The method comprises using a variable dose drug delivery device to respond modifications during the adaptive clinical trial, wherein the variable dose drug delivery device is able to deliver more than one dose level and is for delivering fluid ...
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Portable devices for detection of antibodies against therapeutic drugs
October 05, 2017 - N°20170285023

Portable devices for anti-drug antibodies (adas) testing are provided. These devices can be used in various applications, including but not restricted to the following: uniform testing of patients for adas; selection of therapeutic drug for patient treatment; evaluation of the need to change therapeutic drug or to apply tolerance regimens; selection of patients for clinical trials; comparison of therapeutic drugs ...
Medication adherence monitoring system and method
Aic Innovations Group, Inc.
September 28, 2017 - N°20170277861

A medication management system is described that is operable to determine whether a user is actually following a protocol, provide additional assistance to a user, starting with instructions, video instructions, and the like, and moving up to contact from a medication administrator if it is determined that the user would need such assistance in any medical adherence situation, including clinical ...
System for assessing drug efficacy and response of a patient to therapy
September 28, 2017 - N°20170276676

A system for identifying, monitoring and matching patients with appropriate treatments using a systemic mediator-associated physiologic test profile are provided. The system of the present invention increases the likelihood of demonstrating clinical efficacy in clinical trial datasets.
Methods and systems for collecting spirometry data
Eresearchtechnology, Inc.
September 28, 2017 - N°20170273597

Disclosed herein are spirometers that can be used for assessment of pulmonary lung function. The disclosed systems, computer readable mediums and methods can be directed towards use in a variety of settings by health care professionals, clinical trial specialists, and individual users.
Method and system for improving site activation through critical path management and improving patient enrollment ...
September 21, 2017 - N°20170270279

The present invention discloses methods for improving clinical trial planning and clinical trial operations deliverables. Specially, this invention introduces methods on shortening enrollment cycle time and/or improving more effective utilization of resources through critical path management in site activation and improvement of patient enrollment in focused site management.
Method of performing clinical trials
August 24, 2017 - N°20170242979

An online clinical trial enrollment system enables patients to directly input their data for standardized processing. It has the steps of a. A patient-operated device for reading displayed commands and inputting responses; b. A server programmed to archive and process data from a plurality of patients, compare, analyze and aggregate information, perform statistical analysis and produce reports on a viewing ...
Biomarkers and methods relating to alzheimer's disease
King's College London
August 03, 2017 - N°20170219611

Alzheimer's disease, the most common cause of dementia in older individuals, is a debilitating neurodegenerative disease for which there is currently no cure. In the past, ad could only be definitively diagnosed by brain biopsy or upon autopsy after a patient died. These methods, which demonstrate the presence of the characteristic plaque and tangle lesions in the brain, are still ...
Methods for predicting risk of developing hypertension
Critical Care Diagnostics, Inc.
August 03, 2017 - N°20170219610

Methods using biomarkers, e. G., serum levels of st2, to predict risk of developing hypertension, as well as methods for treating subjects to reduce the risk of developing hypertension and methods for selecting and/or stratifying subjects for clinical trials of treatments to reduce the risk of hypertension.
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