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This page is updated frequently with new Chromatography-related patent applications. Subscribe to the Chromatography RSS feed to automatically get the update: related Chromatography RSS feeds. RSS updates for this page: Chromatography RSS RSS


Retardation film, process for producing polarizer, and liquid-crystal display device

Konica Minolta

Retardation film, process for producing polarizer, and liquid-crystal display device

Date/App# patent app List of recent Chromatography-related patents
03/26/15
20150087816
 Doped materials for reverse phase chromatography patent thumbnailnew patent Doped materials for reverse phase chromatography
A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 μmol/m2 to 0.8 μmol/m2 referred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 μmol/m2. Such material and suitable purification conditions for active pharmaceutical ingredients (apis) like peptides can be evaluated by (a) determining the isoelectric point (pi) of the api of interest, (b) choosing a ph in a range where the solid phase material is stable, (c) determining the difference pi-ph and (d) if the difference pi-ph is positive, choosing an anion exchange (aiex) material, or if the difference pi-ph is negative, choosing an cation exchange (ciex) material..
Zeochem Ag
03/26/15
20150087073
 Methods for quantifying polypeptides using mass spectrometry patent thumbnailnew patent Methods for quantifying polypeptides using mass spectrometry
A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of comprising an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent comprising an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent comprising an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole..
Waters Technologies Corporation
03/26/15
20150086974
 Immunochromatographic test strip and detection method using immunochromatography for detecting target in red blood cell-containing sample patent thumbnailnew patent Immunochromatographic test strip and detection method using immunochromatography for detecting target in red blood cell-containing sample
A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions..
Sekisui Medical Co., Ltd.
03/26/15
20150085217
 Retardation film, process for producing polarizer, and liquid-crystal display device patent thumbnailnew patent Retardation film, process for producing polarizer, and liquid-crystal display device
The purpose of the present invention is to provide a retardation film which includes cellulose acetate having a low degree of acyl substitution and, despite this, swells very little when immersed in a saponifying solution and which has satisfactory adhesion to polarizing elements. This retardation film comprises: a cellulose ester which has a total degree of substitution with acyl groups of 2.0-2.55 and in which when log [mw(a)] obtained through analyses by gel permeation chromatography (gpc), low angle laser light scattering (lalls), and viscosity measurement, is plotted as abscissa and log [iv(a)], obtained through the analyses is plotted as ordinate, the plot has a slope of 0.65-0.85; and a glass-transition-temperature lowering agent having an sp value of 9.0-11.0.
Konica Minolta, Inc.
03/19/15
20150080558
 Chromatography matrices including novel staphylococcus aureus protein a based ligands patent thumbnailChromatography matrices including novel staphylococcus aureus protein a based ligands
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
Emd Millipore Corporation
03/19/15
20150080554
 Affinity chromatography matrix patent thumbnailAffinity chromatography matrix
The invention discloses an immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal protein a (e, d, a, b, c) or protein z or a functional variant thereof, wherein in at least one of the one or more mutated monomers, the asparagine or histidine at the position corresponding to h18 of the b domain of protein a or of protein z has been deleted or substituted with a first amino acid residue which is not proline or asparagine and wherein, if the amino acid residue at position 57 is proline and the amino acid residue at position 28 is asparagine, then the amino acid residue at the position corresponding to h18 of the b domain of protein a or of protein z is not serine, threonine or lysine.. .
Ge Healthcare Bio-sciences Ab
03/19/15
20150079692
 Method of determining phenoxy herbicides in water samples by phase transfer microextraction with simultaneous derivatization and gas-chromatography mass-spectrometry analysis patent thumbnailMethod of determining phenoxy herbicides in water samples by phase transfer microextraction with simultaneous derivatization and gas-chromatography mass-spectrometry analysis
A method for determining the concentration of a phenoxy herbicide in an aqueous sample, by simultaneously phase-transfer catalyst extracting and alkylating an aqueous sample comprising a phenoxy herbicide to form a sample composition, and measuring an amount of the alkylated phenoxy herbicide in the sample composition. The method includes controlling factors such as ph of the aqueous matrix, temperature, extraction duration, type and amount of derivation reagents, and type and amount of phase transfer catalyst..
King Fahd University Of Petroleum And Minerals
03/19/15
20150079691
 Catalytic oxidation of polar modifiers in chromatographic mobile phases patent thumbnailCatalytic oxidation of polar modifiers in chromatographic mobile phases
The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol.
Waters Technologies Corporation
03/19/15
20150079608
 Method for detecting or quantifying analyte, kit for detecting or quantifying analyte, and test strip for lateral flow type chromatography  detecting or quantifying analyte patent thumbnailMethod for detecting or quantifying analyte, kit for detecting or quantifying analyte, and test strip for lateral flow type chromatography detecting or quantifying analyte
A method for detecting or quantifying an analyte, using a test strip for lateral flow type chromatography which contains a membrane and a detection part on which a capturing ligand that is to specifically bind to the analyte has been fixed on the membrane, includes: bringing an analyte contained in a sample into contact with a labeled ligand labeled with a phosphor that is to be excited by light having a wavelength from 600 nm to 800 nm to generate fluorescence, bringing a complex containing the analyte and the labeled ligand into contact with a capturing ligand at the detection part, and irradiating on the test strip light having a wavelength from 600 nm to 800 nm as an excitation light for the phosphor contained in the complex to generate fluorescence from the phosphor, and measuring a fluorescence intensity of the fluorescence.. .
Konica Minolta, Inc.
03/19/15
20150079601
 Methods of nucleic acid fractionation and detection patent thumbnailMethods of nucleic acid fractionation and detection
The invention provides methods of detecting a nucleic acid present in a biological sample, comprising combining the biological sample with a lysis buffer to form a lysis mixture comprising nucleic acid released from cells in said biological sample; and subjecting a volume of the lysis mixture to size-exclusion chromatography in a column comprising a volume of size-exclusion medium. In certain embodiments, the lysis buffer separates double-stranded nucleic acid into single-stranded nucleic acid.
Meridian Bioscience, Inc.
03/19/15
20150079581

Detection kit for influenza a virus


The present invention is a test kit for rapidly diagnosing influenza according to the principles of immunochromatography, and the purpose thereof is to provide a test kit for the influenza a virus in which the sensitivity in detecting the influenza a virus is greater than in conventional test kits, and a determination of “positive” is obtained stably and with high precision at an earlier time during the onset of influenza symptoms. The present invention pertains to a kit for detecting influenza a virus, in which an antibody that is in solid phase in the chromatographic medium enters into an antigen-antibody reaction with native nuclear proteins of the influenza a virus, but in western blots the antibody does not enter into antigen-antibody reactions with full-length nuclear proteins of the influenza a virus that have been separated using sds-polyacrylamide gel electrophoresis..
Tanaka Kikinzoku Kogyo K.k.
03/19/15
20150078962

Microfluidic flame ionization detector


The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber.
Waters Technologies Corporation
03/19/15
20150076342

Method and system for introducing make-up flow in an electrospray ion source system


An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample.
Dh Technologies Development Pte. Ltd.
03/19/15
20150076068

Active inlet temperature control for adjustment of retention in a liquid chromatography system


Described are methods in which the retention times of a chromatographic column are adjusted through the control of the temperature of a mobile phase at the inlet to the chromatographic column. The temperature of the mobile phase at the inlet is different from the temperature of the chromatographic column.
Waters Technologies Corporation
03/19/15
20150075374

Gas chromatography using a thermal gradient that is substantially monotonically non-increasing and has a positive second derivative


A system and method for thermal gradient gas chromatography wherein a front or injection end of a column is heated to a higher temperature than a back or detector end to thereby create a thermal gradient having a profile that is substantially monotonically non-increasing and has a positive second derivative, and then providing a heat source to raise the thermal gradient and cause it to remain stationary or to travel through the column while maintaining a desired profile.. .
Brigham Young University
03/19/15
20150075261

Methods of detecting glycosaminoglycans


In one aspect, the disclosure provides methods of distinguishing a glycosaminoglycan from one or more other components in a sample by subjecting the sample to size-exclusion chromatography using a mobile phase having a ph of 6.8 or lower. A mobile phase having a ph of 6.8 or lower is found to improve the separation of glycosaminoglycans from proteins during size exclusion chromatography.
Biogen Idec Ma Inc.
03/12/15
20150073727

Method and improved quantitation by mass spectrometry


A method of quantifying analytes from mass spectral data, comprising: obtaining a first set of mass spectral data from a first set of analytes eluted from a chromatography column; obtaining a second set of mass spectral data from a second set of analytes eluted from a chromatography column; determining apparent abundances of analytes in each data set; selecting a target analyte and determining localised neighboring analytes by their locality to the target analyte with respect to retention time; determining a locally corrected abundance of the target analyte based on differences between the first and second data sets in the apparent abundance of the localised neighboring analytes; and quantifying the target analyte based on its corrected abundance. A majority of the neighboring analytes are typically substantially unchanged in actual abundance between the first and second data sets and can be used for aligning the abundances between the data sets..
Thermo Fisher Scientific (breman) Gmbh
03/12/15
20150073128

Chromatography ligand


The present invention relates to a chromatography ligand defined by the following formula r1—r2—n(r3)—r4—r5 wherein r1 is a substituted or non-substituted phenyl group; r2 is a hydrocarbon chain comprising 0-4 carbon atoms; r3 is a hydrocarbon chain comprising 1-3 carbon atoms; r4 is a hydrocarbon chain comprising 1-5 carbon atoms; and r5 is oh or h. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane.
Ge Healthcare Bio-sciences Ab
03/12/15
20150072918

Protein purification


A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one or more contaminants.. .
Genentech, Inc.
03/05/15
20150065696

Apparatus and process for purification of proteins


The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter.
Abbvie, Inc.
03/05/15
20150065689

Single step fractionation method


Single step method of enriching highly sialylated variant/s of a protein by use of a strong ion exchange chromatography support and a ph gradient in absence of any salt gradient.. .
Dr. Reddy's Laboratories Limited
03/05/15
20150064735

Method for the determination of sequence variants of polypeptides


The current invention is directed to a method for determining amino acid sequence mutations in a produced polypeptide, comprising the following steps of a) providing a sample of a produced polypeptide, b) incubating the polypeptide in the sample with a protease, c) performing a two dimensional analysis using reversed phase chromatography coupled with a high resolution mass spectroscopy (ft-icr/ft-orbitrap) and ms/ms analysis of the amino acid sequence fragments of the peptides, d) data evaluation by comparing the lc-ms data sets obtained for the samples side by side with the data set of a reference sample, by searching for differences in the signal intensities at given retention times and by evaluation of differential signals with respect to amino acid sequence mutations. The reference sample for data evaluation (d) can be either a well characterized standard or one of the samples to be analyzed..
Hoffmann-la Roche Inc.
03/05/15
20150064692

Immunochromatographic test strip and detection method using immunochromatography for detecting target in red blood cell-containing sample


A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions..
Sekisui Medical Co., Ltd.
03/05/15
20150064093

Mesoporous silica and organosilica materials and process for their preparation


In this invention, we disclose a method as well as silica and/or organosilica mesoporous materials obtained by templating using nanocrystalline cellulose and removal of the latter using acidic conditions. The resultant mesoporous silica materials are characterized by having high surface area with tunable iridescence resulting from the long-range chiral nematic organization.
Fpinnovations
03/05/15
20150060342

Porous adsorptive or chromatographic media


A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity.
Emd Millipore Corporation
03/05/15
20150059440

Vacuum ultraviolet absorption spectroscopy system and method


An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.
03/05/15
20150059439

Fluidic devices and methods using them


Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system..
Perkinelmer Health Sciences, Inc.
02/26/15
20150057205

Highly aromatic base oil and producing highly aromatic base oil


A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 mpa, a temperature of 280 to 400° c., a hydrogen oil ratio of 300 to 750 nl/l, and a space velocity of 0.3 to 2.0 h−1.
Jx Nippon Oil & Energy Corporation
02/26/15
20150056654

Process for the purification of recombinant albumin


A process is provided for the preparation of a highly pure albumin solution the process comprising subjecting albumin (preferably expressed and secreted by transformed yeast) to a series of chromatographic steps. Preferably, the process comprises the steps of positive mode cation exchange chromatography, positive mode anion exchange chromatography, positive mode affinity chromatography, negative mode affinity chromatography (preferably using immobilised aminophenylboronic acid), negative mode cation exchange chromatography, and negative or positive mode anion exchange chromatography.
Novozymes Biopharma Dk A/s
02/26/15
20150056196

Antibody purification by cation exchange chromatography


A method for purifying an antibody by cation exchange chromatography is described in which a high ph wash step is used to remove of contaminants prior to eluting the desired antibody using an elution buffer with increased conductivity.. .
Genentech, Inc.
02/26/15
20150052984

Uv/vis hplc photometer


An ultraviolet-visible spectrophotometry (uv/vis) high-performance liquid chromatography (hplc) photometer includes a nano flow cell in which a light source feeds a reference light channel and a sample light channel, a reference photodiode for evaluating the reference light channel, and a sample photodiode for evaluating the sample light channel, which extends through the nano flow cell. To create a photometer whose signal evaluation is improved, respective effective exposure times of the sample photodiode and the reference photodiode are settable separately from one another..
Sunchrom Wissenschaftliche Geräte Gmbh
02/19/15
20150048015

Corrosion protection in tubing used in chromatography


An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold.
Waters Technologies Corporation
02/19/15
20150047730

Method and sample injection in liquid chromatography


The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves.
Waters Technologies Corporation
02/19/15
20150047500

Force balance needle valve pressure regulator for carbon dioxide based chromatography


Exemplary embodiments of the present disclosure relate to systems and methods comprising a dynamic pressure regulator and a force balance needle that regulate pressure changes due to flow or composition changes in a pressurized flow system, such as, for example, a co2-based chromatography system.. .
Waters Technologies Corporation
02/19/15
20150047422

Introducing samples into supercritical fluid chromatography systems


A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve.
Waterstechnologies Corporation
02/12/15
20150045256

Mass spectrometry quantitation of p450 protein isoforms in hepatocytes


A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.
02/12/15
20150044718

On-column enzymatic cleavage


Herein is reported a method for obtaining a polypeptide by an immobilized metal ion affinity chromatography from a pro-polypeptide that comprise at its n- or c-terminus an metal ion affinity chromatography tag and a protease cleavage site comprising the step of recovering the polypeptide from the immobilized metal ion affinity chromatography column by incubating the bound pro-polypeptide with a protease, whereby the immobilized metal ion affinity chromatography material has been washed at least once with an urea solution.. .
Hoffmann-la Roche Inc.
02/12/15
20150044715

Method for analyzing formyl glycine residue


Disclosed is a method which enables semiquantitative or quantitative determination of the ratio between cysteine and formylglycine residues in a protein. The method includes (a) a step of labeling the protein (i) with a halogen-substituted carboxylic acid, (ii) with a halogen-substituted carboxylic acid amide, and (iii) with a halogen-substituted carboxylic acid and then with hydrazine, or with a halogen-substituted carboxylic acid and then by oximation, (b) a step of digesting each labeled protein to provide a corresponding mixture of peptide fragments, (c) a step of subjecting each mixture to reverse phase chromatography to separate the peptide fragments from each other to produce a chromatogram, (d) a step of comparing the produced chromatograms with each other to identify the peak corresponding to the peptide fragment that contained a cysteine residue and the peak corresponding to the peptide fragment that contained a formylglycine residue..
Jcr Pharmaceuticals Co., Ltd.
02/12/15
20150044466

Aqueous silane coupling agent composition, making method, surface treating agent, and article


A composition comprising a silane coupling agent having dicarboxylic acid group and water is provided. The composition has a solid content of 0.5-50 wt % based on the entire composition and a volatile organic compound content of up to 10 wt % based on volatile components which are detectable by headspace gas chromatography.
Shin-etsu Chemical Co., Ltd.
02/12/15
20150044311

Method for extracting and separating ginkgolides


A method for extracting and separating ginkgolides. The ginkgolides obtained through steps of extraction on a ginkgo leaf, further extraction, column chromatography, crystallization, and crystal mixing comprise 25.0% to 50.0% of bilobalide (c15h18o8), 20.0% to 45.0% of ginkgolide a (c20h24o9), 10.0% to 30.0% of ginkgolide b (c20h24o10), and 5.0% to 15.0% of ginkgolide c (c20h24o11).
Chengdu Baiyu Technology Pharmacy Co., Ltd.
02/12/15
20150042089

High pressure fitting for a liquid chromatography system


A fitting for coupling fluidic paths, such as high pressure fluidic paths in liquid chromatography systems, includes a compression nut, a tube assembly and a compression member. The compression nut has a threaded outer surface to engage a threaded bore of a receiving port and the tube assembly has an outer surface and an end face to contact a sealing surface of the receiving port.
Waters Technologies Corporation
02/12/15
20150041381

Chromatography column


chromatography columns having at least one assembly comprising a backing plate adhesively bound to a flow distributor, and methods of making and using the columns are disclosed.. .
Pall Corporation
02/12/15
20150040889

Process for producing a particulate composition comprising crystalline trehalose dihydrate


A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals.
Hayashibara Co., Ltd.
02/12/15
20150040756

Regulator for improved thermal and pressure control for chromatography


Exemplary embodiments of the present disclosure include systems, apparatuses, and methods that are directed to controlling pressure in a pressurized flow system, such as a c02-based chromatography system or other pressurized flow systems. Exemplary embodiments of the present disclosure comprise one or more apparatuses, systems or methods for implementing multiple pressure regulators to control pressure.
Waters Technologies Corporation
02/12/15
20150040648

Liquid chromatography device, liquid chromatography analysis process, and non-transitory computer-readable medium


A liquid chromatography device includes an adsorption portion that adsorbs one or more analysis components in a specimen, an analysis device that analyzes an analysis component eluted by an eluent, a main feeding device that feeds a first eluent to the adsorption portion, the first eluent eluting an analysis component, a feeding channel in fluid communication with the main feeding device and the adsorption portion, a first retention channel that retains a second eluent, the second eluent differing from the first eluent, an auxiliary feeding device that feeds the second eluent to the first retention channel, and a first switching device that switches the feeding channel to either a first channel or a second channel, the first channel allowing the first eluent to flow from the main feeding device to the adsorption portion, and the second channel allowing the second eluent to flow from the first retention channel to the adsorption portion.. .
Arkray, Inc.
02/05/15
20150037873

Method for endotoxin removal


The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.. .
Ge Healthcare Bio-sciences Ab
02/05/15
20150034813

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis


A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange.
Micromass Uk Limited
01/29/15
20150032383

Method and system for filtering gas chromatography-mass spectrometry data


This invention relates to a system for and a method of filtering at least a part of gas chromatography-mass spectrometry data, the method comprising: providing gas chromatography-mass spectrometry data (301) for a gas mixture comprising data representing one or more gas chromatography elution peaks obtained for at least one sample, and filtering the gas chromatography-mass spectrometry data (301) to reduce the amount of data, wherein the filtering comprises taking into account predetermined data representing one or more elution peaks previously determined to be false positives (305) and/or predetermined data representing one or elution peaks previously determined to be true positives (304). In this way, unreliable elution peaks are removed in an expedient manner reducing the amount of data e.g.
Koninklijke Philips N.v.
01/29/15
20150031779

Preparation of molecular imprinted polymers by cross-linking


Provided is an improved method for preparation of insoluble molecular imprinted polymers (mips), the method comprising: a) providing soluble or semi-soluble mips that 1) substantially all bind template agents and 2) have sizes which enable their separation in a chromatographic step utilizing packed bed chromatography, b) cross-linking the template agent binding soluble mips provided in step a so as to obtain insoluble template agent binding mips, and c) optionally isolating, concentrating or purifying the mips obtained by the cross-linking in step b. In an interesting embodiment, step a includes an affinity purification procedure, which ensures that the mips provided in step a are indeed all binders of the template..
Mipsalus Aps
01/29/15
20150031581

Methods and kits for determining protein-bound biomarkers


(a) automated prepurification of the sample using an effective amount of an acid protease under conditions that allow for digestion of one or more binding proteins; (b) applying said protease-digested sample onto an on-line spe column to capture at least part of said biomarker, followed by sequential washing of the solid phase; (c) eluting a fraction comprising said biomarker directly onto a liquid chromatography (lc) column comprising an apolar stationary phase and subjecting it to lc-ms or lc-ms-ms measurements to determine the amount of at least one biomarker; and (d) quantitating the biomarker(s). Also provided are kits for use in such method, for instance in the determination of vitamin d derivatives, testosterone and/or or melatonin..
01/29/15
20150030976

Black toner for developing latent electrostatic image and producing the same


A black toner for developing a latent electrostatic image, including: a toner base containing a pigment, a binder resin, a releasing agent, a compound containing fluorine and a compound containing sulfur; and an external additive, wherein the toner contains the external additive on a surface of the toner base, and wherein an amount of the fluorine in the toner base is 200 ppm by mass to 600 ppm by mass as measured by combustion-ion chromatography, and an amount of the sulfur in the toner base is 1,000 ppm by mass to 1,500 ppm by mass as measured by the combustion-ion chromatography.. .
01/29/15
20150030565

Purification of flaviviruses


The present invention provides a method to prepare purified enveloped (e.g., flavivirus) viral particle preparations employing ion exchange chromatography and tangential flow filtration.. .
Sanofi Pasteur Biologics, Llc
01/29/15
20150027953

Application of macroporous silica synthesized by a salt-templated aerosol chromatography


The present invention discloses a silica particle having a diameter less than or equal to 2 μη, wherein the particle is spherical and comprises interconnected pores having a diameter in the range from 50 nm to 300 nm. The silica particle is preferably produced by spray pyrolysis (=spray drying) of a silica colloid.
Indiana University Research And Technology Corporation
01/29/15
20150027206

Analytical methods for analyzing and determining impurities in dianhydrogalactitol


An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (hplc), in particular, hplc with refractive index (ri) detection; the hplc can be followed by tandem mass spectroscopy.
Del Mar Pharmaceuticals
01/29/15
20150027203

Controlling interdetector band broadening


Methods and apparatus for controlling interdetector band broadening during the analysis of a sample injected into a chromatography system. A column flow is diluted with a dilution flow after the sample exits the chromatography system, and the diluted sample is analyzed by one or a combination of analysis instruments such as a light scattering detector, refractive index detector, an ultraviolet absorption detector..
Wyatt Technology Corporation
01/22/15
20150024511

Functionalized lipid modification of solid phase surfaces for use in chromatography


A solid phase for use in separation has been modified using an aqueous phase adsorption of a headgroup-modified lipid to generate analyte specific surfaces for use as a stationary phase in separations such as high performance liquid chromatography (hplc) or solid phase extraction (spe). The aliphatic moiety of the lipid adsorbs strongly to a hydrophobic solid surface, with the hydrophilic and active headgroups orienting themselves toward the more polar mobile phase, thus allowing for interactions with the desired solutes.
Clemson University
01/22/15
20150024510

Performing chemical reactions and/or ionization during gas chromatography-mass spectrometry runs


A gas chromatography-mass spectrometry (gc-ms) method that includes performing a first gc-ms run on a sample using a gas chromatography-mass spectrometry system. Performing the first gc-ms nm includes i) passing a first flow of a carrier gas carrying a first portion of the sample through a gas chromatograph to provide a first effluent; ii) generating first ions under protonation conditions by passing the first effluent through an atmospheric pressure ionization source; iii) passing the first ions through a mass spectrometer; and iv) recording first gc-ms data for the first ions.
Waters Technologies Corporation
01/22/15
20150024503

Method of analyzing hemoglobins


The present invention provides a method for analyzing hemoglobins by liquid chromatography which includes pre-treating a sample with an oxidant and a binder for trivalent heme iron.. .
01/22/15
20150024411

Chromatographic isolation of cells and other complex biological materials


The present invention relates to the chromatographic isolation of a target cell or another complex biological material, in particular by column chromatography such as affinity chromatography or gel permeation chromatography. The invention employs a receptor binding reagent that binds to a receptor molecule that is located on the surface of a target cell.
Stage Cell Therapeutics Gmbh
01/22/15
20150024324

Toners for electrostatic-image development


An emulsion polymerized agglomerated toner characterized in that the odor index of aliphatic aldehydes measured by gas chromatography is at most 300, and an emulsion polymerized agglomerated toner which is an emulsion polymerized agglomerated toner obtainable via a polymerization step, a flocculation step and an aging step, characterized in that an emulsion polymerized latex before the flocculation step is a latex having a peroxide value of at most 30.. .
01/22/15
20150024152

Metal components with inert vapor phase coating on internal surfaces


The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for lc analyses in which the sample interacts with metal ions or surfaces.
Agilent Technologies, Inc.
01/22/15
20150023979

Antibodies against e7 protein of human papilloma virus (hpv)


The invention discloses a method for preparing human papilloma virus protein e7 antigen (hpv e7 antigen) comprising the following steps: —providing a purified preparation of hpv protein e7; —phosphorylating the hpv protein e7 in the preparation; —purifying the phosphorylated e7 protein with an anion exchange chromatography, wherein the phosphorylated e7 protein is separated from the non-phosphorylated e7 protein by a step wherein the non-phosphorylated e7 protein stays bound to an anion exchanger during the anion exchange chromatography whereas the phosphorylated e7 protein is obtained in the eluate of the anion exchange chromatography, thereby—obtaining a purified preparation of a phosphorylated hpv protein e7 antigen. The invention further discloses antibodies specific to this antigen, a kit and method for using such antibodies in clinical diagnostics and methods for generation of such antibodies..
Valdospan Gmbh
01/22/15
20150021265

Flow splitting in supercritical fluid chromatography systems


A method includes passing a mobile phase fluid flow comprising liquefied co2 through a separation column; then introducing a makeup fluid flow into the mobile phase fluid flow to form a mixed fluid flow; and then splitting the mixed fluid flow.. .
Waters Technologies Corporation
01/22/15
20150020575

System for analyzing a gas mixture including at least one chromatography column


A system for analyzing a gas mixture, including at least one chromatography column, a mechanism injecting the mixture into the column, and a mechanism detecting compound(s) forming the gas mixture, the detection mechanism including at least one detector of nanosensor type of an outlet of the column and a detector of nanosensor type in the column, capable of detecting passage of the compounds. It is then possible to determine the velocity of each of the compounds within the system..
California Institute Of Technology
01/15/15
20150018241

Fc-receptor based affinity chromatography


Herein is reported the use of an immobilized non-covalent complex of a neonatal fc receptor (fcrn) and beta-2-microglobulin (b2m) as affinity chromatography ligand in general and, for example, for the determination of the in vivo half-live of an antibody by determining the ratio of the retention times of the antibody and a reference antibody.. .
Hoffmann-la Roche Inc.


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Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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