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Chromatography patents



      
           
This page is updated frequently with new Chromatography-related patent applications. Subscribe to the Chromatography RSS feed to automatically get the update: related Chromatography RSS feeds. RSS updates for this page: Chromatography RSS RSS


Methods for injecting samples in liquid chromatography, particularly in high performance liquid chromatography

Methods for injecting samples in liquid chromatography, particularly in high performance liquid chromatography

Automated system for handling components of a chromatographic system

Automated system for handling components of a chromatographic system

Date/App# patent app List of recent Chromatography-related patents
11/20/14
20140339170
 Stackable planar adsorptive devices patent thumbnailStackable planar adsorptive devices
Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs compressive stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing.
11/20/14
20140338431
 Methods for injecting samples in liquid chromatography, particularly in high performance liquid chromatography patent thumbnailMethods for injecting samples in liquid chromatography, particularly in high performance liquid chromatography
A sample injection method for liquid chromatography is performed with an injection valve having a waste port, two sample loop ports, and two high-pressure ports. One high-pressure port can be connected to a pump and the other high-pressure port can be connected to a chromatography column.
11/20/14
20140338430
 Automated system for handling components of a chromatographic system patent thumbnailAutomated system for handling components of a chromatographic system
An automated system for handling components of a chromatographic system, comprising: one or more trap columns each having sorbent material therein; a robotic system for moving a trap column from a storage position to an operating position where the trap column is connected in a liquid pathway along which solvent is flowed in operation to a liquid chromatography (lc) column; and an optical sensor for sensing one or more parameters of the trap column. Sensed parameters can include: a presence or absence of a trap column in the operating position, a position or orientation of the trap column, a fluid level in the trap column, the presence and position of a sorbent material in the trap column, the condition of the trap column and/or whether the trap column is new or used..
11/13/14
20140335086
 Modified heat shock protein-antigenic peptide complex patent thumbnailModified heat shock protein-antigenic peptide complex
The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography.
11/13/14
20140332695
 Ionization at intermediate pressure for atmospheric pressure ionization mass spectrometers patent thumbnailIonization at intermediate pressure for atmospheric pressure ionization mass spectrometers
An ion source able to ionize liquid and gaseous effluents from interfaced liquid or gaseous separation techniques and from direct introduction of the analyte to the entrance of the ionization region. The liquid effluents from sources such as a liquid chromatograph are ionized by inlet ionization methods and the gaseous effluents from sources such as a gas chromatograph are ionized by a corona or townsend electrical discharge, or an alpha or beta emitter, or by inlet ionization, or by photoionization.
11/13/14
20140332387
 Current efficient electrolytic device and method patent thumbnailCurrent efficient electrolytic device and method
A sandwich suppressor in an ion chromatography system in which loosely packed ion exchange resin of low density is disposed in the central sample stream flow channel. Also, a method of using the suppressor is described..
11/06/14
20140329995
 Affinity chromatography matrix patent thumbnailAffinity chromatography matrix
The invention discloses a polypeptide capable of binding immunoglobulins or immunoglobulin-containing proteins, which polypeptide comprises six or more domains of protein z or the c domain of protein a or a functional variant thereof. It also discloses separation matrices comprising the polypeptide and methods of using the separation matrices for separation of immunoglobulins or immunoglobulin-containing proteins..
11/06/14
20140329673
 Porous particles for liquid chromatography and processes for the preparation thereof patent thumbnailPorous particles for liquid chromatography and processes for the preparation thereof
Superficially porous silica particles are provided as well as a one-pot process for making the superficially porous particles, the process comprising hydrolyzing and condensing a silica precursor comprising a functional group to form superficially porous particles, the superficially porous particles comprising silica microparticles having silica nanoparticles bound to the surface of the microparticles. The nanoparticles provide a porous outer layer on the microparticles.
11/06/14
20140326670
 Methods and apparatus for time-pulsed chromatography patent thumbnailMethods and apparatus for time-pulsed chromatography
The present disclosure relates to methods for the chromatographic separation of two or more sample components using a column while applying a time-pulsed pressure differential to the column and to apparatus for use in the same.. .
11/06/14
20140326664
 Select valve for liquid chromatography patent thumbnailSelect valve for liquid chromatography
A liquid chromatography system includes a pumping system with a selector valve in fluidic communication with a pump inlet. The selector valve switches between a first position, in which the selector valve fluidically couples a solvent reservoir to the pump inlet, and a second position, in which the selector valve fluidically couples a pressurized source of liquefied carbon dioxide (for example) to the pump inlet.
11/06/14
20140326650
Pump and injector for liquid chromatography
A combined dual pump-injector valve utilizing a single piece of material to house the barrel for each of the two piston-based pumps and to provide the stator of the associated valve, thus eliminating any need for connections between the pumps and the valve, and therefore eliminating the potential for high-pressure leaks or pressure reductions. The combined dual pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample..
11/06/14
20140326279
Cleaning equipment of sample bottle for chrimatography analysis and cleaning method thereof
A cleaning equipment of sample bottle for chromatography analysis comprising: a base; a support frame vertically fixed to the base; a horizontal column having two ends, wherein one of the ends is disposed at the support frame through an adjustment knob; a rotary drive device fixed to the other end of the horizontal columns; a rotation disk which can rotate through driving of the rotary drive device, and a side edge of the rotation disk provides with multiple placing holes for receiving and fixing sample bottles; a cleaning agent recycling tank disposed below the rotation disk, wherein a side wall of it provides with an ejector pipe connected with a water pump; and a control unit for controlling on/off and rotation speed of the rotary drive device, and on/off of the water pump. The invention also provides a cleaning method of sample bottle for chromatography analysis..
11/06/14
20140326055
Chromatography of metal complexes
A high performance liquid chromatography method to routinely and reproducibly detect and quantitate metal complexes is provided. The metal complexes used in the method of the invention can be different metal complexes, or they can be stereoisomers of the same metal complexes.
10/30/14
20140323698
Protein purification using bis-tris buffer
The invention provides a two-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four buffer solutions made from a mother solution.. .
10/30/14
20140323697
Media for affinity chromatography
The invention relates generally to solid supports for chromatography. In specific embodiments the invention provides for solid supports suitable for affinity chromatography along with methods, systems and kits which use the same..
10/30/14
20140322699
Affinity-based analytical purification of biotherapeutics for bioprocess monitoring
The invention as disclosed herein provides a method for purifying a non-antibody protein from solution, comprising a chromatography step wherein the solution is passed over an affinity construct containing an affinity ligand-coupled solid support, wherein the affinity construct is associated with a bioprocess unit operation, and isolating the non-antibody protein from solution.. .
10/30/14
20140322643
Toner and developer
A toner including a non-crystalline polyester resin and a crystalline polyester resin, wherein a tetrahydrofuran soluble component of the non-crystalline polyester resin has a weight-average molecular weight of 3,000 to 8,000 measured by gel permeation chromatography, and wherein the toner has a glass transition temperature a before an extraction process of the toner with methanol and a glass transition temperature b after the extraction process of the toner with methanol, and a difference between a and b (b−a) is 2.0° c. Or less..
10/30/14
20140322194
Methods for preparing factor x, activated factor x, inactivated factor x and inactivated factor xa, and pharmaceutical compositions comprising same
Methods for preparing factor x, activated factor x, inactivated factor x and inactivated factor xa, compositions comprising factor x and factor xa, inactivated factor x and inactivated factor xa and methods of medical treatment using factor x, factor xa, activated factor x and inactivated factor xa are disclosed. The preparation methods comprise a chromatography step using an immobilised metal ion affinity chromatography substrate..
10/30/14
20140319057
Chromatographic materials for the separation of unsaturated molecules
The present disclosure relates to a method of separating a compound of interest, particularly unsaturated compound(s) of interest, from a mixture. The compound is separated using a column having a chromatographic stationary phase material for various different modes of chromatography containing a first substituent and a second substituent.
10/23/14
20140316114
Method for preparing active form of tnfr-fc fusion protein
The present invention relates to a method for separating and preparing a tnfr-fc fusion protein using hydrophobic interaction chromatography (hic). More particularly, the present invention relates to a method for separating and preparing a highly pure active protein from clipped proteins due to displacement effect by adjusting the conductivity of a protein sample using a high concentration of salt solution and by adjusting a loading amount thereof, and a tnfr-fc fusion protein prepared by the method..
10/23/14
20140316108
Protein chromatography matrices with hydrophilic copolymer coatings
A coating of a random copolymer of acrylamide and a second monomer, e.g. Glycidoxylmethacrylate, for a silica surface is described.
10/23/14
20140315322
Method for measuring acetic acid concentration in blood plasma
The present invention relates to providing a simple and highly reproducible method for measuring the concentration of acetic acid in blood plasma by using a gas chromatography/mass spectrometry (gc/ms), and more specifically relates to a method for measuring the concentration of acetic acid in blood plasma by using a gas chromatography/mass spectrometry (gc/ms), which comprises extracting acetic acid in blood plasma with methyl-tert-butyl ether (mtbe).. .
10/23/14
20140315318
Analytical methods for analyzing and determining impurities in dianhydrogalactitol
An improved analytical method for analysis of dianhydrogalactitol preparations provides a method for determining the purity of dianhydrogalactitol and detecting impurities in preparations of dianhydrogalactitol, as well as identifying any such impurities. The method employs high performance liquid chromatography (hplc), in particular, hplc with evaporative light scattering detection (elsd); the hplc can be followed by tandem mass spectroscopy.
10/23/14
20140315231
Quantification of transthyretin and its isoforms
The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry.
10/23/14
20140311977
Use of organic solvent nanofiltration and liquid-liquid chromatography for the recovery of pharmaceutical products
A process for separating a compound from solution in organic solvent by a chromatographic process, in particular liquid-liquid chromatography, in which prior to the chromatographic process the composition of the solution is changed by means of a process of organic solvent nanofiltration for a solvent exchange. Additionally or alternatively subsequent to the chromatographic process the output from the chromatographic process is subjected to a process of organic solvent nanofiltration to remove residual target compound and/or impurities in the output for solvent recovery..
10/16/14
20140306105
Liquid chromatrography systems and methods
One aspect of the invention provides a liquid chromatography system including: a first solvent manager configured to dispense various ratios of a first solvent and a second solvent; a first column in fluid communication with the first solvent manager; a mixer in fluid communication with the first column; a first valve in fluid communication with the mixer; a second column having a first end in fluid communication with a first port of the first valve and a second end in fluid communication with a second port of the first valve; a second solvent manager adapted and configured to dispense various ratios of a third solvent and a fourth solvent; and a second valve in fluid communication with the second solvent manager, the first valve, and the mixer. The first valve and the second valve are adapted and configured for actuation between and a second position.
10/16/14
20140305195
Preparative column chromatography system
A chromatography system comprising a mixing circuit or a mixing chamber, a bubble trap, a concentration detector and one or more pumps, characterized in that the bubble trap has a permanent opening at its highest point is described herein. Furthermore, a chromatography system is described, characterized in that it contains two concentration detectors the first of which is located in the mixing circuit or the mixing chamber and the second is located downstream of the main pump..
10/09/14
20140303060
Process for degrading a biofilm on surfaces of objects
Optionally followed by further purification steps, such as ion-exchange chromatography and/or concentration.. .
10/09/14
20140303014
Multiplexed detection with isotope-coded reporters
Some aspects of this invention provide reagents and methods for the sensitive, quantitative and simultaneous detection of target analytes in complex biological samples by liquid chromatography tandem mass spectrometry (lc ms/ms). Some aspects of this invention provide affinity reagents encoded with mass reporters for the sensitive and quantitative translation of an analyte of interest into a mass tag.
10/09/14
20140302592
Protein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140302591
Protein purification by anion exchange chromatography
The present invention relates to a two-step method for the purification of divalent cation binding proteins with high yield and high purity on anion exchange resin materials, to divalent cation binding proteins obtainable by said method, and to a kit comprising means for carrying out said method.. .
10/09/14
20140301977
Overload and elute chromatography
The present invention provides methods for purifying a polypeptide from a composition comprising the polypeptide and at least one contaminant by overloading a chromatography material and eluting the product.. .
10/09/14
20140301757
Toner, developer using the toner, image forming apparatus
A toner including at least a crystalline resin as a binder resin, wherein a tetrahydrofuran soluble content of the toner includes 5.0% or more as a peak area of a component having a molecular weight of 100,000 or greater in a molecular weight distribution measured by gel permeation chromatography, and the tetrahydrofuran soluble content of the toner has a weight-average molecular weight of 20,000 to 60,000.. .
10/09/14
20140299765
Apparatus for improved immunosuppressant drug monitoring
A liquid chromatography/mass spectrometry system includes: a source of a first mobile phase solvent consisting essentially of water plus 10 mm ammonium formate plus 0.05% formic acid; a source of a second mobile phase solvent consisting essentially of methanol plus 10 mm ammonium formate plus 0.05% formic acid; a chromatography column comprising a length of 30 mm or less of a stationary phase comprising an 8-carbon alkyl chain material bonded to 2.6 μm diameter particles having solid silica cores surrounded by porous silica outer layers; an electrospray ion source of a mass spectrometer fluidically coupled to the chromatography column so as to generate ions therefrom; a mass analyzer of the mass spectrometer operable to quantitatively detect the ions; and a programmable processor electronically coupled to the mass analyzer and comprising instructions operable to determine, based on the ion detection, a concentration of everolimus, sirolimus, tacrolimus, or cyclosporin a.. .
10/09/14
20140299542
Method and system for liquid chromatography fluidic monitoring
A method for monitoring a fluidic system of a liquid chromatography system is characterized by: (a) drawing a fluid into a syringe pump; (b) configuring a valve so as to fluidically couple the pump to either a fluidic pathway through the fluidic system or to a plug that prevents fluid flow; (c) causing the syringe pump to progressively compress the fluid therein or expel the fluid to the fluidic pathway, while measuring a pressure of the fluid; (d) determining a profile of the variation of the measured pressure; (e) comparing the determined profile to an expected profile that depends upon the fluid; and (f) providing a notification of a sub-optimal operating condition or malfunction if the determined profile varies from the expected profile by greater than a predetermined tolerance.. .
10/09/14
20140299510
Slurry oil upgrading while preserving aromatic content
Methods relating to methods for producing a needle coke precursor from slurry oil having low levels of nitrogen and sulfur. Nitrogen-containing compounds are removed by chromatography, followed by hydrotreating at relatively mild conditions that focus on the more easily-removed sulfur-containing compounds while largely preserving aromatic content of the slurry oil.
10/09/14
20140298990
Devices and methods for adaptive micro-gas chromatography
The present disclosure provides adaptive methods for gas chromatography analysis of a gas sample comprising one or more target analytes (such as a micro-gas chromatography) and adaptive gas chromatography devices for carrying out such analytical methods. Broadly, the system can regulate flow into a downstream chromatographic column by detecting one or more upstream conditions.
10/09/14
20140298924
Chromatography apparatus and method
Sample preparation device for receiving in sealing relation one or more filter assemblies and one or more sample containers, each container uniquely positioned within the device to receive filtered sample from a designated filter. The device includes a body, a lid disposed on the body, a container tray, a base, an integrated seal on the body, a valve and a valve actuator.
10/02/14
20140296500
Methods and compositions of nucleic acid ligands for detection of clinical analytes related to human health
Specific dna sequences for binding various clinically relevant analytes from the human body are described. Each of these sequences or their linear, two- and three-dimensional linked sequences can function in varying assay and sensor formats with varying degrees of success.
10/02/14
20140296485
Anionic displacer molecules for hydrophobic displacement chromatography
A process for separating organic compounds from a mixture by reverse-phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic anionic displacer molecule and about 10 wt % or less of an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic anionic displacer molecule comprises a hydrophobic anion and a counterion, ci, having the general formula a or b, as defined in the disclosure: [cm][cl]d [cm-r*—cm′][cl]d a b.. .
10/02/14
20140296464
Chromatography medium
The present invention provides a chromatography medium comprising one or more electrospun polymer nanofibres which form a stationary phase comprising a plurality of pores through which a mobile phase can permeate and use of the same in chromatography, such as the isolation of recombinant proteins, monoclonal antibodies, viral vaccines and plasmid dna. The invention further provides for the use of the chromatographic medium in a simulated moving bed system..
10/02/14
20140296434
Chromatography matrices including novel staphylococcus aureus protein a based ligands
The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
10/02/14
20140295405
Chromatography method, and chromatography kit
The chromatography method of the present invention includes (a) developing a complex of a test substance and a labeling substance modified with a first binding substance bindable to the test substance, onto an insoluble carrier, (b) causing the complex to be trapped in a reaction site on the insoluble carrier which contains a second binding substance bindable to the test substance or a substance exhibiting binding properties to the first binding substance, (c) washing the insoluble carrier with a washing solution containing at least one of the potassium iodide, urea, and guanidine after the step (b), (d) washing off the washing solution of the step (c) remaining in the insoluble carrier from the insoluble carrier, and (e) amplifying the labeling substance of the complex trapped in the reaction site.. .
10/02/14
20140294745
Coral extract for skin whitening, moisture retention, elasticity improvement, anti-inflammation and occlusion of wounds and extracting method thereof
A coral extract for skin whitening, moisture retention, elasticity improvement, anti-inflammation and occlusion of wounds and its extracting method is provided. The coral extract is extracted from briareum excavatum.
10/02/14
20140290645
Methods and controllers for simulated moving bed chromatography for multicomponent separation
A system for reacting and separating solid and fluid components includes a series of sequential simulated moving bed (smb) chromatography columns connected to form a circulation loop. Each smb chromatography column includes an inlet and an outlet.
10/02/14
20140290491
Column unit and gas chromatography device provided with the same
A housing of a column unit is tubular-shaped, and includes a first opening and a second opening, and an inner space separated from outside air by an insulating material. An air cooling section including a cooling device is arranged on a side of the first opening of the housing.
09/25/14
20140288278
Chromatography process for resolving heterogeneous antibody aggregates
Disclosed are methods and processes utilizing multi-modal chromatography as a polishing step to separate heterogeneously charged (basic and acidic) aggregates and other impurities from partially a partially purified bulk product monoclonal antibody product. The resulting chromatographic process provides a scaleable production process that is cost effective and increases the productivity of the purification process over a platform utilizing a combination of anion and cation exchange chromatography to resolve heterogeneous aggregates..
09/25/14
20140287146
Production process of film and column for cation chromatography
One object of the present invention is to produce a weakly acidic cation exchanger under mild conditions. Another object of the present invention is to produce a more firm weakly acidic cation exchange film.
09/25/14
20140284472
Ion mobility spectrometer
A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
09/25/14
20140284279
Apparatus, system and method for mass directed chromatography
The present invention provides an apparatus that can be used to connect a flash chromatography instrument to a fraction collector and a mass detector to perform mass-directed flash chromatography.. .
09/25/14
20140284278
Cationic displacer molecules for hydrophobic displacement chromatography
A process for separating organic compounds from a mixture by reverse-phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic cationic displacer molecule and about 10 wt % or less of an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic cationic displacer molecule comprises a hydrophobic cation and a counterion, ci, having the general formula a or b, as defined in the disclosure:. .
09/25/14
20140284277
Processing biomass materials
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, equipment, systems and methods are described that can be used to treat feedstock materials, such as cellulosic and/or lignocellulosic materials.
09/25/14
20140284270
Rna pores and methods and compositions for making and using same
Synthetic rna molecules having a pore, compositions including rna molecules having a pore, where the compositions are capable of filtering metal ions, filtering molecular ions, performing size exclusion chromatography, performing ion specific chromatography, reversible metal ion and molecular ion binding, ion selective membranes, ion selective channels, ion selective/specific sensors, electrical conduits, battery components, etc., and devices and methods for making and using same. The rnas used may be modified to improve stability.
09/25/14
20140284260
Chromatography column
A chromatography column having a longitudinal axis and comprising a column wall with a first end and a second end, a first end plate assembly removably connectable to said first end of the column wall, a second end plate assembly removably connectable to said second end of the column wall, wherein said first end plate assembly, said column wall and said second end plate assembly are arranged along the longitudinal axis of the column wherein the column wall, and/or first end plate assembly and/or second end plate assembly is/are rotatable about an axis of rotation wherein said axis of rotation is parallel to the longitudinal axis of said column and positioned outside the column. .
09/25/14
20140283688
Self cleaning gas-liquid separator for serial or parallel collection of liquid fractions
An apparatus, process, and system are disclosed that effectively provide separation of a combined gas/liquid flow stream into its separated gas and liquid factions. The invention is primarily directed to the fields of preparative supercritical fluid chromatography [sfc] and supercritical fluid extraction [sfe], but will have other utilization and applicability where phases of dramatically different density, viscosity and volumetric flow require separation..
09/18/14
20140275594
New process for reducing pollutants in fats and oils and their derivatives
The present invention describes a process to reduce or eliminate at least one pollutant in a starting material, said starting material is at least one of an oil, a fat, its derivatives and mixtures thereof, of animal, krill, algae or microbial origin or biofuel, being totally or partially esterified or transesterified, or of vegetable origin, being raw, esterified or transesterified, to which optionally it is added a fluid, said fluid is at least one of an ester, a partial glyceride, a monoglyceride, a diglyceride and mixtures thereof, subjecting the starting material to at least one stage of extraction or chromatography or distillation. The process of the invention provides a product suitable to be used in food, pharmacy, cosmetic and as a dietary supplement..
09/18/14
20140275494
Protein purification using displacement chromatography
Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to compositions and methods for isolating and purifying proteins incorporating a displacement chromatographic step.
09/18/14
20140275438
Bulk hydrophilic functionalization of polyamide 46
A modified polymer as result of a bulk functionalization of polyamide 46 (pa 46) is presented, as well as methods for synthesizing the modified polymer. This functionalization of pa 46 is performed to provide a homogenous semi-permeable polyamide 46 capable of different charges and different porosities with particles of nanoscale size in order to replace or improve other polyamide fibers used in the textile industry, filtering processes, selective sorption, controlled release devices, phase transfer catalysts, chromatography media, biocompatible capsules, artificial skins, organs, bone void repair as well as in cell bioreactors and incubators, dental implements, medical devices, clothing, detectors, perfusion devices, in regenerative medicine, and fuel cells..
09/18/14
20140274782
Affinity reagents and methods for detection, purification, and proteomic analysis of methylated proteins
Methyl-lysine affinity reagents created by engineering the 3×mbt methyl-lysine binding domain repeat of lethal (3) malignant brain tumor-like protein 1 (l3mbtl1) are disclosed. In particular, the invention relates to affinity reagents and affinity chromatography media comprising the 3×mbt domain repeat and methods of using such affinity reagents in detection, purification, and proteomic profiling of methylated proteins and peptides..
09/18/14
20140274751
Chemical identification using a chromatography retention index
Provided herein is technology relating to identifying unknown compounds and particularly, but not exclusively, to methods and systems for identifying unknown compounds by gas chromatography-mass spectrometry by use of retention index as a second dimension for identification.. .


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Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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