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Chromatography patents


This page is updated frequently with new Chromatography-related patent applications.

Date/App# patent app List of recent Chromatography-related patents
 Test piece for immunochromatography, developing fluid used therefor, and immunochromatography using the same patent thumbnailnew patent Test piece for immunochromatography, developing fluid used therefor, and immunochromatography using the same
A test piece for immunochromatography, containing an aggregation inhibiting pad, a conjugate pad, and a membrane, in which the membrane contains a test area for capturing a target substance, the aggregation inhibiting pad contains a desalting agent, and the conjugate pad contains a labeling agent.. .
Furukawa Electric Co., Ltd.

 Beverage test apparatus patent thumbnailnew patent Beverage test apparatus
A beverage test apparatus, including a container, for containing beverage to be tested; an opening disposed on the container, the opening being covered by a one-way valve, for allowing entrance of the beverage into the container, and for disallowing exit therefrom, and a chromatography substance contained in the container, for changing a color of the chromatography substance upon presence of a certain ingredient, thereby a portion of beverage poured into the cup enters the container and is tested by the chromatography substance, and thereby the one-way valve disallows access of the chromatography substance to the beverage being drunk by the user, where the beverage test apparatus may further include a sticker attached to the container, for sticking the container to the drinking cup.. .

 Method for the isolation and purification of anhydrogalactose patent thumbnailnew patent Method for the isolation and purification of anhydrogalactose
The present invention discloses a method for isolating and purifying anhydrogalactose. Using the method for isolating and purifying anhydrogalactose including the steps of preparing a sugar mixture containing anhydrogalactose produced through chemical synthesis and hydrolysis; and isolating anhydrogalactose by performing recycling preparative liquid chromatography (recycling-prep-lc) with the sugar mixture, highly pure anhydrogalactose can be efficiently isolated and purified in large amounts..
Biolsystems Co., Ltd.

 Polystyrene-containing composite resin particles and  producing same, expandable composite resin particles, pre-expanded particles, and expanded molded article patent thumbnailnew patent Polystyrene-containing composite resin particles and producing same, expandable composite resin particles, pre-expanded particles, and expanded molded article
Polystyrene-based composite resin particles includes 100 to 500 parts by weight of a polystyrene-based resin with respect to 100 parts by weight of an ethylene-vinyl acetate copolymer resin. The polystyrene-based composite resin particles are impregnated with a volatile blowing agent and are pre-expanded to obtain pre-expanded particles; the obtained pre-expanded particles are immersed in tetrahydrofuran for 24 hours to obtain an extract a; and the pre-expanded particles are divided into two halves through the center to prepare halved particles, and the halved particles are immersed in tetrahydrofuran for 24 hours to obtain an extract b; and the obtained extract a and extract b are subjected to a gpc (gel permeation chromatography) measurement and obtain the following results: the polystyrene-based resin having a weight-average molecular weight (mw) of 100,000 to 500,000 gives a peak obtained from chromatograms for the extract a and for the extract b..
Sekisui Plastics Co., Ltd.

 Purified cardiogenin isomer and related methods patent thumbnailnew patent Purified cardiogenin isomer and related methods
A cardiogenin major isomer is obtained from a methanol extract of geum japonicum and separated from its minor isomer. The separation of the two isomers can be achieved by chiral phase chromatography, e.g., using a chiralpak® ic™ column.
Huya Bioscience International Llc

 Preparative chromatography column patent thumbnailnew patent Preparative chromatography column
A chromatography column design and a packing device, as well as a method for obtaining a column with a very compact and uniform bed are provided. The bed remains compact and uniform during operation of the column and during sanitization, storage and transportation of the column.
Bio-rad Laboratories, Inc.

 Supercritical fluid-liquid chromatograph, and analysis method thereof patent thumbnailSupercritical fluid-liquid chromatograph, and analysis method thereof
A back pressure valve configured to switch between a pressurized state and a released state open to an atmosphere is used as a back pressure valve in a supercritical fluid chromatograph. Switching from a state of supercritical fluid chromatography analysis to liquid chromatography is performed by stopping a pump that supplies a supercritical fluid, continuously operating a pump that supplies a solvent used as a modifier, and bringing the back pressure valve into the released state..
Shimadzu Corporation

 Chromatography ligand comprising domain c from staphylococcus aureus protein a for antibody isolation patent thumbnailChromatography ligand comprising domain c from staphylococcus aureus protein a for antibody isolation
The present invention relates to a chromatography ligand, which comprises domain c from staphylococcus protein a (spa), or a functional fragment or variant thereof. The chromatography ligand presents an advantageous capability of withstanding harsh cleaning in place (cip) conditions, and is capable of binding fab fragments of antibodies.
Ge Healthcare Bio-sciences Ab

 Purification process for pth patent thumbnailPurification process for pth
The present invention relates to improved method for purification of a recombinant parathyroid hormone (rhpth1-34 or teriparatide), said process for purification of parathyroid hormone comprising following essential steps: (a) enzymatic cleavage; (b) anion exchange chromatography, followed by other suitable purification steps; wherein step (a) and (b) can be carried out in any order.. .
Cadila Healthcare Limited

 Buoyant protein harvesting device patent thumbnailBuoyant protein harvesting device
A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification.. .
Therapeutic Proteins International, Llc


Process for separating a divinyl hydrocarbon from monovinyl hydrocarbons and/or non-vinyl compounds

A process for separating a divinyl hydrocarbon from a composition mixture stream containing at least a divinyl hydrocarbon and other components, the process including (a) passing a composition mixture feed stream containing at least (i) a divinyl hydrocarbon; and (ii) a monovinyl hydrocarbon, and/or (iii) a non-vinyl hydrocarbon through a process-scale chromatography unit; wherein the process scale chromatography unit includes a ligand exchange media comprising a metal adapted to form a ligand with an olefin functionality; wherein the metal of the ligand exchange media is loaded on an adsorbent; and wherein the divinyl hydrocarbon is adsorbed onto the ligand exchange media; (b) passing a weak first elution solvent through the unit to elute the monovinyl hydrocarbon and/or the non-vinyl hydrocarbon from the unit; (c) passing a strong second elution solvent through the unit to elute the divinyl hydrocarbon product stream from the unit; and (d) recovering the divinyl hydrocarbon product stream having been separated from the other components in the composition mixture stream; and an apparatus therefor.. .
Blue Cube Ip Llc


Mobile phase controller for supercritical fluid chromatography systems

The present disclosure relates to an apparatus for regulating the average mobile phase density or pressure in a carbon dioxide based separation system. The apparatus includes a controller, a set of pressure or density sensors and a set of instructions capable of determining the pressure drop across a column and adjusting at least one system component or parameter to achieve a pre-determined average mobile phase density or pressure in the system..
Waters Technologies Corporation


Automated sampling and reaction system for high pressure liquid chromatography and other types of detection

Automated sampling and reaction systems and methods of using the same are provided. The automated sampling and reaction system has a microreactor in fluidic communication with an external sampling valve.
Waters Technologies Corporation


Methods for determination of total homocysteine

Disclosed herein are simple, rapid and cost effective methods for determination of endogenous sulfhydryl amino acid species from a sample, example a sample in clinical practice. The method can include mixing of a biological sample with an internal standards which does not require pretreatment or derivatization and/or isotopic dilution.
Castle Medical, Llc


Method for chiral separation of methamphetamine and amphatamine enantiomers

Methods for routine high throughput analysis with accurate results to determine the concentration of d- and/or l-isomers of methamphetamine and/or amphetamine in biological samples is provided. In some examples, the method includes mixing of a biological sample with an internal standard and diluting with a mobile phase, followed by eluting on a chiral stationary phase contained in a liquid chromatography column.
Castle Medical, Llc


Modular automated chromatography system

Valves, pumps, detectors, sample loops, fraction collectors and the like are individually incorporated into modules that are mountable in interchangeable manner at individual mounting sites on a base unit which also supports one or more chromatography columns. Each module includes fluid connections to other modules and a microcontroller joining the module to a computed and monitor through an electronic connector at each mounting site.
Bio-rad Laboratories, Inc.


Chromatographic device and method

A chromatographic device for analysing multiple samples comprises a separator for separating the multiple samples, an injector unit for injecting the multiple samples into the separator, the injector unit being provided as regular injector unit for single-sample chromatography, a detector for detecting signals of the multiple samples after they are separated by the separator, a sequence generator for generating a specific binary sequence for each of the multiple samples, a controller that controls the injector unit so that each of the multiple samples is injected into the separator in pulses corresponding to its specific binary sequence, and a decomposer for decomposing the detected signals of the multiple samples by identifying the specific binary sequences in the detected signals.. .
Ruprecht-karts-universitat Heidelberg


Protein a chromatography

The present invention provides methods for cleaning a protein a chromatography column employing a media comprising a protein a ligand derived from the c domain of staphylococcus aureus, such that the column can be cleaned using both acidic and alkaline solutions.. .
Emd Millipore Corporation


Method for separating fat-soluble substance by simulated moving bed chromatography - and device for same

The present invention provides a separation method and device, comprising columns with at least two types of gels selected from the group consisting of silica gel, silver nitrate-impregnated gel and polymer gel filled therein, preferably at least three silver nitrate-impregnated gel columns and at least one silica gel column, by smb chromatography. The present invention also provides a separation method and device, comprising columns with at least two types of columns selected from the group consisting of c18 columns, c8 columns c4 columns and c1 columns, preferably at least three c18 columns and at least one c8 column and/or c4 column and/or c1 column, by smb chromatography..
Bizen Chemical Co., Ltd.


Protein products and methods for making the same

According to one embodiment, a protein product may include a mixture of water and particulate matter comprising protein. The mixture may include medium chain aldehydes and pyrazines.
Kraft Foods Group Brands Llc


Thin-layer chromatography type radiation detector

A thin-layer chromatography type radiation detector includes a plurality of light-emitting members configured to generate visible light due to radiation, each of the light-emitting members including a scintillator having a surface filled with a reflector for reflecting the visible light, and are arranged in parallel to one another in a width direction, light sensors respectively coupled to one end portions of the plurality of light-emitting members and configured to measure a current generated due to the visible light generated by the plurality of light-emitting members, and an output port configured to sequentially output values of the current measured by the light sensors as digital signals.. .


Proteomic biomarkers of sepsis in elderly patients

A proteomic expression platform to identify age-related sepsis risk is disclosed using patients with community-acquired pneumonia. A semi-quantitative plasma proteomics workflow was applied which incorporated tandem immuno affinity depletion, itraq labeling, strong cation exchange fractionation, and nanoflow-liquid chromatography coupled to high resolution mass spectrometry.


Method of amplifying detection light using light-reflecting material in immunochromatography

The present invention intends to provide an immunochromatographic test piece that makes it possible to achieve both highly sensitive detection of a substance to be detected and a simple test piece structure, which are usually difficult to be made compatible with each other. The immunochromatographic test piece is an immunochromatographic test piece comprising a membrane on which a capture substance being a ligand that bonds to a substance to be detected is immobilized, wherein insoluble carrier particles to which a ligand that bonds to the substance to be detected is bound are used and accumulated by being captured with the capture substance immobilized on the membrane, the membrane is irradiated with light to detect light emitted from a portion where the insoluble carrier particles are accumulated or light emitted from a portion surrounding and other than the portion where the insoluble carrier particles are accumulated, thereby measuring the substance to be detected, and a light-reflecting material is provided on a side of the membrane opposite to a side irradiated with light..


Method and system for detecting boron ions using ion chromatography for online monitoring of steam generator tube leakage in light water reactor

The present invention relates to an online leakage monitoring technique of a steam generator tube for monitoring leakage of the steam generator tube by analyzing concentration of an extremely small amount of boron ions in the secondary side solution of the steam generator in which a variety of ions are mixed, and the present invention is effective in that concentration of an extremely small amount of boron ions can be accurately detected, maintenance is convenient and durability is improved since analysis time is reduced considerably and operation pressure is lowered greatly by using ion chromatography provided with a boron trapping column optimized for trapping an extremely small amount of boron ions and a deionization water supplier for rising a sample line, instead of general ion chromatography provided with a concentration column and a separation column.. .


Apparatus and introducing sample into a separation unit of a chromatography system without disrupting a mobile phase

A method and a system for introducing a sample into a mobile phase of a chromatography system is provided. The method includes initially directing the mobile phase directly into a separation unit of the chromatography system, bypassing a sample loop, the mobile phase including a combined solvent, metered from a pressurized first solvent and a second solvent; loading the sample into the sample loop, while the mobile phase continues to be directed directly into the separation unit; pressurizing the sample in the sample loop with the pressurized first solvent, while the mobile phase continues to be directed directly into the separation unit; and switching the sample loop into the mobile phase, thereby introducing the pressurized sample to the separation unit..


Ethyleneimine polymer and producing the same

An ethyleneimine polymer, in which the number average molecular weight (mn) of the ethyleneimine polymer measured by gel permeation chromatography in terms of pullulan is 13,000 or more and the value obtained by dividing the weight average molecular weight by the number average molecular weight (weight average molecular weight: mw/number average molecular weight: mn=degree of dispersion) of the ethyleneimine polymer is from 1.4 to 3.0.. .


Purification of chimeric fviii molecules

The invention is directed to methods of purifying a chimeric protein comprising subjecting the chimeric protein to a factor viii-specific affinity chromatography, and subjecting the chimeric protein to an aex chromatography; wherein the chimeric protein comprises a factor viii protein or a fragment thereof. The chimeric protein purified by the present methods shows improved factor viii activity..


Solid phase for mixed-mode chromatographic purification of proteins

Proteins are purified by a mixed-mode chromatography system formed by attaching a ligand with cation exchange and hydrophobic functionalities to a large-pore support matrix, the only linkage between the ligand and the support matrix being a chain having a backbone of no more than three atoms between the hydrophobic group and the support matrix.. .


Fluid mixer assembly

Disclosed is an assembly for mixing fluids (i.e., gases or liquids), and more particularly an assembly that accurately mixes two or more high-pressure fluid sources and is adapted for use in applications, such as for example, chromatography. The mixer assembly (100) includes, inter alia, a housing (10), an inlet fitting (40), and a mixer cartridge assembly (60).


Chromatographic columns and separation devices comprising a superficially porous material; and use thereof for supercritical fluid chromatography and other chromatography

The present invention provides novel chromatographic materials, e.g., for chromatographic separations, processes for its preparation and separations devices containing the chromatographic material; separations devices, chromatographic columns and kits comprising the same; and methods for the preparation thereof. The chromatographic materials of the invention are superficially porous chromatographic particulate materials comprising sized less than 2 microns..


Means for generating cell-disintegrated blood

A method for analyzing a whole blood sample can include injecting whole blood into a first zone of a dual zone sample loop, applying sufficient heat or energy to the whole blood to disintegrate the cellular components of the whole blood sample to produce cell disintegrated blood, and injecting a sufficient volume of the buffer into the dual zone sample loop to move the cell disintegrated blood into a second zone of the dual zone sample loop. The method can further include switching a multiport value to an inject position, flowing the cell disintegrated blood from the dual zone sample loop into a solid phase extraction column, and eluting components of the cell disintegrated blood from the solid phase extraction column into a liquid chromatography column..


Fluid composition and reservoir analysis using gas chromatography

Methods are provided for reservoir analysis. In some embodiments, a reservoir may be analyzed by obtaining abundance ratios at a first measurement station and a second measurement station and determining an abundance ratio trend.


Fluid composition using optical analysis and gas chromatography

Methods and systems are provided for determining a gas/oil ratio using gas chromatography and optical analysis of a fluid sample obtained using a fluid sampling tool. In some embodiments, a gas/oil ratio may be determined from the mass fraction of each light component of the fluid, the mass fraction of each intermediate component of the fluid, a molecular weight of each light component of the fluid, a molecular weight of each intermediate component of the fluid, the density of stock tank oil, the vapor mass fraction of the intermediate components of the fluid, and the mass fraction of the plus fraction of the fluid.


Devices and methods for controlling reversible chemical reactions at solid-liquid interfaces by rapid preconcentration and phase replacement

Devices and methods for controlling reversible chemical reactions at solid-liquid interfaces are disclosed. In particular, the invention relates to a method of increasing reaction rates by concentrating a target molecule in a liquid phase in the region of a reactant or ligand immobilized on a solid followed by removal of the liquid phase and replacement with an immiscible phase, such as an immiscible gas or liquid to impede the reverse reaction.


Filter element and filtration assembly for biopharmaceutical applications

Provided are filter elements or cells and filtration assemblies or capsules for purifying and/or clarifying fluids used during various biopharmaceutical applications, for example, chromatography or depth filtration, and processes for making and using the same. A filter element comprises a media pack comprising two sides and a separator element located between the two sides, at least one side comprising a filtration media, wherein an inner edge periphery and/or an outer edge periphery of the filtration media comprise a bond directly to a portion of the separator element..


Aluminum chlorohydrate salts exhibiting high sec peak 3

An aluminum chlorohydrate salt having a peak 3:peak 4 ratio of at least 10:1 and an amount of peak 3 material relative based on a total of peaks 2, 3, 4, and 5 is at least 80% as measured by size exclusion chromatography, together with water treatment compositions, antiperspirant compositions, and oral care compositions, comprising the same, and methods for making and using the same.. .


Techniques for determination of haloacetic acid ("haa") presence in aqueous solution

A real-time method and analytical system for determining haloacetic acids in water which operate by: (1) extracting samples on ion-exchange absorbent medium; (2) concentrating haloacetic acids on hyper-crosslinked medium; (3) eluting the analytes from the concentration medium for injection into an hplc system; (4) separating individual haloacetic acid in reverse-phase chromatography performed by the hplc system; and (5) measuring optical characteristics (uv-absorbance) of haloacetic acids, to determine concentration. The entire process can be performed using a completely self-contained, in-situ mechanism that sits at a water distribution point for 24/7 testing, with automated control, monitoring, reporting, and employment of remedial measures (e.g., automated adjustment of the water treatment process)..


Pre-assembled separation columns

There is provided an integrated system for liquid separation, such as lc, ce, affinity chromatography, and ion exchange chromatography, comprising a column and end-fittings embedded in a plastic material, such as a thermoplastic polymer. The system may further comprise an electrospray emitter directly connected with the outlet of the column, wherein a substantial part of the emitter is covered with the polymer material.
Proxeon Biosystems A/s


Method for manufacturing a gas phase chromatography column and column obtained using such a method

The present invention also relates to a capillary column as well as to a microcolumn which may be manufactured according to this method.. .


Pressure sensing and flow control in diffusion-bonded planar devices for fluid chromatography

Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel.
Waters Technologies Corporation


Purification virus-like particles

The present invention aims at establishing a novel means for purifying norovirus vlps. There is provided a purification method of norovirus virus-like particles, comprising: contacting solution containing norovirus virus-like particles with support for hydroxyapatite chromatography, binding the virus-like particles to the support, subsequently washing the support with buffer, and then eluting the virus-like particles from the support with buffer containing phosphate, wherein the phosphate concentration of the buffer used for elution is less than 10 mm..
Umn Pharma Inc.


Affinity chromatography matrix

The invention relates to an affinity chromatography matrix, as a gel, comprising polymeric particles on which at least one oligosaccharide corresponding to a blood group a epitope and/or blood group b is grafted, via a spacer, characterized in that the density of oligosaccharides is comprised between 0.2 and 0.7 mg/ml of matrix. The invention also relates to the uses of this matrix for preparing concentrates of immunoglobulins for therapeutic use..
Laboratoire Francais Du Fractionnement Et Des Biotechnologies


Chromatography matrices including novel staphylococcus aureus protein a based ligands

The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
Emd Millipore Corporation


Process for the preparation of high purity miglustat

A process for the preparation and isolation of crystalline miglustat without the use of a column chromatography or ion exchange purification. The crystalline miglustat has a high purity and a melting point of 128° c.


Preparative chromatography column and methods

A chromatography column that captures components in a process liquid in a free flow state and allows elution in steps is described.. .
Therapeutic Proteins International, Llc


Ev71 virus-like particles and preparation method and application thereof

The present invention provides ev71 virus-like particles and a preparation method and application thereof. The method comprises: connecting a p1 protein gene and a 3cd protease gene of an ev71 virus with a pmv plasmid to construct a pmv-p1-3cd recombinant expression plasmid; then transforming a hansenula polymorpha au-0501 expression strain with the pmv-p1-3cd recombinant expression plasmid to obtain an au-pmv-p1-3cd recombinant expression strain; fermenting and culturing the recombinant expression strain, and inducing the recombinant expression strain to express the ev71 virus-like particle protein with methanol; centrifuging and collecting mycelia for homogeneous breakage at a high pressure; and purifying the supernatant through ion-exchange chromatography, hydrophobic chromatography, and molecular sieve chromatography, so as to obtain ev71 virus-like particles..
Beijing Minhai Biotechnology Co., Ltd


Antibody-mediated anti-tumor activity induced by reishi mushroom polysaccharides

Immunogenic compositions, cancer vaccines and methods for treating cancer comprising fms, the fucose-enriched polysaccharide fraction from reishi f3, are provided. Compositions comprise fucose-enriched reishi polysaccharide fraction (fms) mw=˜35 kda, wherein the fms is isolated by size-exclusion chromatography from reishi f3, and the fms comprises polysaccharides having primarily a backbone selected from 1,4-mannan and 1,6-α-galactan, wherein the backbone is linked to a terminal fucose-containing side-chain immunogenic compositions comprising glycolipid adjuvants are provided.
Academia Sinica


Elucidation of ion exchange chromatography input optimization

The present invention provides methods for determining chromatography separation conditions; for example, separation of a polypeptide and its charge variants. The invention also provides methods to determine a buffer condition for chromatography separation conditions.
Genentech, Inc.


High resolution analyte recovery system and method

Analyte separation systems for use in conjunction with chromatography separation devices and techniques are described. Disclosed systems include modular components that can provide for individualized design of separation schemes to better fit the needs of the user.
Clemson University


Stackable planar adsorptive devices

Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing.
Spf Technologies Llc


Backflush methods and devices for chromatography

Certain embodiments described herein are directed to chromatography systems that include a microfluidic device and that implement one or more methods to direct sample to a desired fluid flow path. The methods can be used to backflush a sample to a desired fluid flow path to select certain analytes within a sample..


Purification of long chain diacids

The present disclosure relates to methods for separating and purifying a long chain diacid from other long chain diacids, monocarboxylic acids, hydroxyl acids or alkanes by simulated or actual moving bed chromatography.. .
Invista North America S.á.r.l.


Modified diamond particles

Modified diamond particles for use in chromatography with a desired functional group at the diamond surface, formed from reaction of hydroxyl groups at diamond surfaces with a reactive molecule.. .
Brigham Young University


Ring shaped counter electrode to improve beam stability and compound sensitivity on a ceramic tile type microfluidic device

An interface for a mass spectrometer is disclosed comprising a microfluidic substrate, tile or cartridge 1 comprising a liquid chromatography separation column and an electrospray emitter 2. A counter electrode 4 is arranged downstream of a tip of the electrospray emitter 2 and is arranged and adapted to direct ions towards an atmospheric pressure interface or ion inlet aperture 5 of a mass spectrometer..
Micromass Uk Limited


Monolithic column chromatography

Provided herein are methods of liquid column chromatography in which preparative chromatography is performed in-line with analytical chromatography. In particular aspects a monolithic preparative column is used to purify an analyte of interest from a mixture of other substances by applying the mixture to the column, reversing the flow through the column to elute the analyte, which is applied to an analytical column provided in-line with the preparative column.
Quest Diagnostics Investments Incorporated


Gradient liquid feed device for sample analyzer

A gradient liquid feed device allows reduction in size of a high performance liquid chromatography type sample analyzer. The gradient liquid feed device includes a plurality of carrier liquid reservoir tanks configured to store carrier liquids of mutually different compositions, a plurality of single plunger pumps capable of drawing and discharging the carrier liquid from the plurality of carrier liquid reservoir tanks, a mixer configured to mix the carrier liquids discharged from the plurality of liquid feed pumps and feed the mixed carrier liquid, and a pulse damper in communication with the mixer and configured to absorb pulsation that may occur during liquid feeding.
Sekisui Medical Co., Ltd.


Liquid chromatography fast measuring

Provided is a liquid chromatography apparatus for fast measuring, and more particularly, a liquid chromatography apparatus which includes a first column and a second column having different component separations for an interest component within a sample and makes components primarily separated in the first column be secondarily separated in the second column of a first channel unit before a switching valve is switched, makes the components primarily separated in the first column be continuously discharged through a second channel unit after the switching valve is switched, thereby improving the component separation and achieving the fast measuring.. .
Whitech Inc.


Inspection tool for nucleic acid chromatography

An inspection tool for nucleic acid chromatography includes an elongated porous sheet and a backing member. The porous sheet has a surface including a detection surface that has a strip-shaped indication portion where a nucleic acid probe for capturing the target nucleic acid is fixed.
Ngk Insulators, Ltd.


Process for increased yield of immunoglobulin from human plasma

The present invention discloses a preparation method for large scale production of human immunoglobulins (igg) with high yields by an improved all-chromatography process scheme that eliminates ethanol precipitation. The process of extracting immunoglobulins is such that the other therapeutic proteins in plasma are left unaffected and are available for extraction separately from the same plasma sample.
Hemarus Therapeutics Limited


Methods for the detection of spoilage of oils

Methods for the detection of spoilage of oils containing unsaturated fatty acids is disclosed. Specific methods include the determination of p-anisidine in oils containing unsaturated fatty acids using high performance liquid chromatography after p-an-isidine is added to the oil containing unsaturated fatty acids, and allowed to react with oxidation products..
Nordic Naturals, Inc.


Method of detecting and quantifying perchlorate contamination

A method of detecting and quantifying perchlorate contamination in samples, especially samples with complex background matrices such as food and produce with trace levels of perchlorate. A simple microwave assisted-electromembrane extraction provides simultaneous reduced extraction time, sample clean-up, high recovery and enrichment of perchlorate ions for detection and quantification by ion chromatography.
King Fahd University Of Petroleum And Minerals


Process for equilibrium-limited reactions

A process for conducting equilibrium-limited chemical reactions that produce water as a reaction product. Specifically, a process that uses a reactive chromatography unit (rcu) to improve the efficiency of equilibrium-limited reactions, such as a process for reacting glycol ether (ge) and carboxylic acid (ca) to form water and glycol ether ester (gee).
Dow Global Technologies Llc


Reactive chromatography process for equilibrium-limited reactions

The present disclosure provides for a process for an equilibrium limited reaction using reactive chromatography unit (rcu) in which a first organic donor reactant (fodr) and a second organic acceptor reactant (soar) react to form a product mixture of a first acceptor product (fap) and a second donor co-product (sdcp). The equilibrium-limited reaction does not produce water.
Dow Global Technologies, Llc


Dynamic lab on a chip based point-of-care device for analysis of pluripotent stem cells, tumor cells, drug metabolites, immunological response, glucose monitoring, hospital based infectious diseases, and drone delivery point-of-care systems

The invention provides for a novel dynamically configurable point-of-care device for clinical diagnostics and research for analysis of activity associated with pluripotent stem cells, tumor cells, drug metabolites, immunological response, glucose monitoring, cardiovascular diseases, liver cell therapy, cell-cell signaling, epidemic outbreaks, hospital based infectious diseases, pathogens, germ cells, pharmacological compounds, oxidation reduction, microscopy, tomography, flow cytometry, clinical lab testing, and for providing immunoassays, elisa, electrophoresis, pcr, chromatography, and other laboratory functions. The device comprises a biochemical processing module further comprising a processor and at least one controller, receiving microfluidic elements, sensors, software scripts, an electrically operated interface, flow ports, a user interface, memory, and a communications link, configurable based on analysis of patient data.


Chromatography column distribution system

A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs.
Ge Healthcare Bio-sciences Ab


Formulations of bendamustine

Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable fluid which can include in some embodiments peg, pg or mixtures thereof and an antioxidant or chloride ion source.
Eagle Pharmaceuticals, Inc.


Formulations of bendamustine

Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable fluid which can include in some embodiments peg, pg or mixtures thereof and an antioxidant or chloride ion source.
Eagle Pharmaceuticals, Inc.


Method for time-alignment of chromatography-mass spectrometry data sets

A method is disclosed for adjusting the time scale of chromatography-mass spectrometry data sets, wherein a time scale of a first data set is used as a reference time scale and wherein a time scale of at least one second data set is adapted to the reference time scale comprising the. The steps of the method include identifying feature groups in the first data set by evaluating intensities of consecutive points of the first data set; identifying feature groups in the second data set by evaluating intensities of consecutive points of the second data set; matching feature groups of the first data set to feature groups of the second data set, and determining a corrected time scale for the second data set based on time differences between feature groups in the first data set and matching feature groups in the second data set..
Thermo Fisher Scientific (bremen) Gmbh


Immunochromatography device for detecting rsv

The present invention provides an easy-to-use and higher-sensitivity immunochromatography device for an rsv, the device using an antibody that binds specifically to f protein of the rsv in a determination region of a chromatography medium, a test kit by an immunochromatography method, and a method for detecting an rsv using these device and kit. The present invention relates to an immunochromatography device in which not only an antibody that binds specifically to f protein of an rsv but also an antibody that binds specifically to n protein of the rsv is solid-phased in a determination region of a chromatography medium.
Tanaka Kikinzoku Kogyo K.k.


Systems and methods of compensation for chromatography column volume variations

Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column.
Waters Technologies Corporation


Carbon dioxide liquid phase forming using high volume head displacement

Systems and methods for pumping carbon dioxide in a chromatography system include an actuator that receives and compresses carbon dioxide at or above room temperature at a given pressure to put the carbon dioxide in or near supercritical form. This actuator can be a pre-pump disposed on the intake side of a pumping system.
Waters Technologies Corporation


Traps for use with chromatography systems

Certain configurations are provided herein of a trap that can be used with chromatography systems. In certain instances, the trap may be designed to remove substantially all oil in a sample comprising the oil and an analyte of interest.
Perkinelmer Health Sciences, Inc.


Nanometer size chemical modified materials and uses

Ligand compositions and stationary phases comprising polyhedral oligomeric silsesquioxane moieties are incorporated in to chromatographic stationary phases, and these phases are incorporated into chromatography devices, such as columns. The compositions and devices are of use to separate molecular mixtures..
Dionex Corporation


Method for detecting methylated dna

Provided is a rapid and simple method of detecting methylated dna. The method of detecting methylated dna includes the following steps of: (1) treating sample dna with a hydrogen sulfite; (2) amplifying the sample dna treated with the hydrogen sulfite by pcr; and (3) subjecting the resultant pcr amplification product to ion-exchange chromatography..
Mie University


Method for producing tricyclic heterocyclic compound

It is an object of the present invention to provide a method for producing a high-purity tricyclic heterocyclic compound represented by formula (i), which is useful as a production intermediate for a pharmaceutical agent, wherein the method is an efficient production method with short steps and with a high yield, which does not use, as raw materials, expensive bromopyruvate and highly harmful copper chromite, and does not need silica gel column chromatography that generates, as by-products, large quantities of waste. The present invention relates to production of compound (i) by the following method..
Daiichi Sankyo Company, Limited


Purification of intermediates used in the preparation of heterobifunctional linkers

The present invention is directed to a method of separating a monocarboxylic represented by the following stmctural formula: (i) from a dicarboxylic acid represented by the following structural fonnula: (ii) using silica chromatography.. .
Immunogen, Inc.


Ion exchange based volatile component removal device for ion chromatography

A method, device, and system for removing a volatile component from a liquid solution for a chromatographic separation are described. The method includes the flowing of a liquid solution through a first chamber of the device.
Dionex Corporation


Methodology for scaling methods between supercritical fluid chromatography systems

A methodology scales supercritical fluid chromatography (sfc) and/or carbon dioxide based chromatography methods between different system and/or column configurations. The methodology includes measuring an average mobile phase density during a first separation utilizing co2 as a mo bile phase component and substantially duplicating the average density profile for a second separation.
Waters Technologies Corporation


Superficially porous particles with precisely controlled particle density, and methods of preparation and use thereof

The invention provides superficially porous metal oxide particles with precisely controlled particle density and to methods for their preparation and use, as well as to separation devices (e.g., high pressure liquid chromatography) having superficially porous particles.. .
Agilent Technologies, Inc.


Method for detection of protein comprising histidine-tag using immunochromatography

The present invention relates to a method for the detection of a protein including a histidine-tag using immunochromatography. The detection method of the present invention uses immunochromatography using the polymer particle fixed with the histidine-tag, wherein a histidine-tag specific antibody alone is used to detect a histidine-tag conjugated protein (recombinant protein) quickly without using a target protein specific antibody.
Daegu Gyeongbuk Institute Of Science And Technology


Enhanced sensitivity of detection in electrospray ionization mass spectrometry using a post-column modifier and a microfluidic device

A microfluidic liquid chromatography-electrospray ionization (lc-esi) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent.
Waters Technologies Corporation


Liquid flow rate measurement device

Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid.
Waters Technologies Corporation


Compositional analysis of a gas or gas stream in a chemical reactor and preparing chlorosilanes in a fluidized bed reactor

The composition of a gas or gas stream containing alcl3 in a chemical reactor is measured by removing alcl3 from the gas and analyzing the gas by gas chromatography or spectroscopy. Chlorosilanes may be prepared in a fluidized bed reactor having a reactor height h0, in which supplied hcl reacts with silicon, wherein a temperature profile in the fluidized bed reactor is greater than s1(h/h0)=(a1−b1)*(1/(1+exp(−c1((h/h0)−d1))))+b1 and less than s2(h/h0)=(a2−b2)*(1/(1+exp(−c2((h/h0)−d2))))+b2, where a1=100° c., a2=300° c., b1=300° c., b2=400° c., c1=50, c2=20, d1=0.2, and d2=0.8..
Wacker Chemie Ag


Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography

Disclosed herein are methods for the isolation and purification of anti-il-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., protein a affinity chromatography), ion exchange chromatography, and hydrophobic chromatography.
Abbvie Inc.

Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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