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Chromatography patents



      
           
This page is updated frequently with new Chromatography-related patent applications.



Date/App# patent app List of recent Chromatography-related patents
02/04/16
20160033526 
 Method for analyzing samples of a biological fluid and  performing the same patent thumbnailnew patent Method for analyzing samples of a biological fluid and performing the same
The present invention relates to methods for continuous or near-continuous separation and purification of samples, particularly biological samples, to reduce the number or volume of non-targeted analytes in those samples to enable improved mass spectrometric analysis of analytes of interest, and apparatuses for conducting those methods, utilizing a transport agent with a core domain and a binding domain, the transport agent exceeding 200 kilodaltons or 10 nm, and the binding domain targeted to the analytes of interest, in conjunction with size-exclusion based chromatography to separate the transport agent-analyte of interest complex from non-targeted analytes that are not bound, or are only non-specifically bound, to the transport agent.. .
Novilytic, Llc


02/04/16
20160033456 
 Gaseous mercury detection systems, calibration systems, and related methods patent thumbnailnew patent Gaseous mercury detection systems, calibration systems, and related methods
Embodiments disclosed herein are directed to gaseous mercury detection systems, calibration systems, and related methods. The gaseous mercury detection systems are configured to detect gas-phase mercury-compounds present in ambient air.
Utah State University


02/04/16
20160033049 
 Multi-path selector valve patent thumbnailnew patent Multi-path selector valve
A multi-path selector valve used in liquid chromatography and other analytical methods for directing fluid along alternate paths of a flowstream. The selector valve has a stator and a rotor.
Idex Health & Science Llc


02/04/16
20160032089 
 Thermoplastic elastomer composition and molded article thereof patent thumbnailnew patent Thermoplastic elastomer composition and molded article thereof
The thermoplastic elastomer composition includes (a) a polypropylene resin, (b) a non-conjugated diene copolymer having a mooney viscosity (ml1+4, 125° c.) of 40 to 85 and a molecular weight distribution of 1.5 to 3.0 and whose eluted amount at −15° c. Measured by cross-fractionation chromatography is 50% to 99.9% of the overall eluted amount, and (c) an ethylene copolymer having a mooney viscosity (ml1+4, 125° c.) of 20 to 30 and a density of 0.850 g/cm3 to 0.890 g/cm3.
Sumitomo Chemical Company, Limited


02/04/16
20160031047 
 Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system patent thumbnailnew patent Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system
A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (cg-ms) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the gc-ms system, at a location between a high vacuum end of a transfer line and a mass analyzer of the gc-ms system.
Thermo Finnigan Llc


02/04/16
20160030542 
 Toxoid, compositions and related methods patent thumbnailnew patent Toxoid, compositions and related methods
Methods of producing purified clostridial toxin comprising tangential flow filtration, hydrophobic interaction chromatography and anion exchange chromatography are disclosed. These methods provide good yields of c.
Sanofi Pasteur, Inc.


02/04/16
20160030369 
 Fkbp52 targeting agent pharmaceutical compositions patent thumbnailnew patent Fkbp52 targeting agent pharmaceutical compositions
Liposomes comprising an fkbp52 targeting agent (fta) are disclosed. Pharmaceutical compositions comprising an fta, a solvent, and a surfactant are disclosed.
The Board Of Regents Of The University Of Texas System


01/28/16
20160025691 
 Chromatography/mass spectrometry data processing device patent thumbnailChromatography/mass spectrometry data processing device
Using the intensity ratio of peaks on a standard mass spectrum of the target compound and peaks with the same m/z on the measured mass spectrum near the retention time of said compound, a scale factor waveform close to the chromatogram shape based on the target compound alone is computed, and m/z candidates for quantitation are extracted based on the correlation between the measured mass chromatogram of the target compound and the scale factor waveform. Furthermore, an intensity ratio is determined with reference to the m/z peaks showing the greatest scale factor on the measured mass spectrum at the measurement time point showing the greatest scale factor in the scale factor waveform, and m/z candidates for quantitation/confirmation are narrowed down based on whether they fall within an allowable range based on peak intensity ratio on the standard mass spectrum..
Shimadzu Corporation


01/28/16
20160024617 
 Methods for gas-phase thermochromatographic separations of fission and activation products patent thumbnailMethods for gas-phase thermochromatographic separations of fission and activation products
Methods are provided for characterizing samples containing chemical elements such as rare earth elements, actinides, and heavy transition metals by treating the samples to form volatile complexes of the elements (e.g., β-diketonate complexes or other organic ligand complexes of the elements) and then analyzing the complexes, for example, via gas-phase thermochromatography. Also provided are methods for separating and/or recovering such chemical elements.
University Of Tennessee Research Foundation


01/28/16
20160024488 
 Method for preparing a concentrate of factor xi patent thumbnailMethod for preparing a concentrate of factor xi
The invention concerns a concentrate of human factor xi having high specific activity prepared using a method comprising a filtration-adsorption step and a chromatography step on cation exchange resin. The concentrate obtained is fully adapted for therapeutic use as substitution therapy in cases of factor xi deficiency..
Laboratoire Francais Du Fractionnement Et Des Biotechnologies


01/28/16
20160024235 

Polymer films having improved heat sealing properties


A polymer composition comprising an ethylene alpha-olefin copolymer, wherein the polymer composition is characterized as having (a) a density in the range of from greater than about 0.910 g/cc to about 0.930 g/cc, as determined according to astm d1505; (b) a melt index in the range of from greater than about 0.5 g/10 min to about 3 g/10 min, as determined by astm d1238, condition 190° c./2.16 kg; (c) a molecular weight distribution of from about 3.4 to about 12, as determined by gel permeation chromatography (gpc); (d) a weight average molecular weight of from greater than about 85 kg/mol to about 160 kg/mol, as determined by gel permeation chromatography (gpc); and (e) a z-average molecular weight of from greater than about 210 kg/mol to about 500 kg/mol, as determined by gel permeation chromatography (gpc).. .
Chevron Phillips Chemical Company Lp


01/28/16
20160024180 

Purification of vwf


The present invention provides a method of purifying multimeric von willebrand factor (vwf) from a solution comprising multimeric vwf and contaminants. The method comprises passing the solution through a chromatography column comprising beads of a mixed mode chromatography resin coated with a size-exclusion inactive shell and collecting the multimeric vwf which passes through the column without binding to the resin..
Csl Limited


01/28/16
20160024147 

Purification platform for bispecific antibodies


High resolution protein a chromatography employing a chaotropic agent and ph gradient or ph step elution buffer results in improved peak resolution between closely related molecular species. Bispecific antibodies containing a protein a-binding-ablating substitution ch3 domain paired with a protein a-binding ch3 domain are separated with high peak resolution from monospecific antibodies containing a protein a-binding-ablating substituted ch3 domain paired with the protein a-binding-ablating substituted ch3 domain and monospecific antibodies containing a protein a-binding ch3 domain paired with the protein a-binding ch3 domain.
Regeneron Pharmaceuticals, Inc.


01/28/16
20160024146 

Methods for purifying antibodies


A method for purifying a protein comprising an antibody, antibody fragment, or immunoglobulin single variable domain, from a solution containing at least one contaminant by superantigen chromatography comprising: a) adsorbing the protein to the superantigen immobilized on a solid support; b) removing the at least one contaminant by contacting the immobilized superantigen containing the adsorbed protein with a first wash buffer comprising an aliphatic carboxylate; and c) eluting the protein from the superantigen immobilized on the solid support.. .
Glaxosmithkline Intellectual Property (no.2) Limited


01/28/16
20160024145 

Hydrophobic interaction protein chromatography under no-salt conditions


Various aspects and embodiments of the present disclosure relate to the purification antibodies by hydrophobic interaction chromatography under no-salt conditions.. .
Biogen Ma Inc.


01/28/16
20160024144 

Removal of leaked affinity purification ligand


The invention provides for the removal of a large fraction of contaminants from protein preparations while maintaining a high level of recovery using tentacle anion exchange matrix chromatography medium. Using the methods of the invention, leached affinity chromatography contaminants can be removed from recombinant protein preparations..
Amgen Inc.


01/28/16
20160024141 

Ion exchange purification of mrna


The current landscape for preparative chromatographic rna purification uses reversed phase hplc, but this technique presents many issues with process scale up and ion exchange for preparative purification has only been used for short rnas. The invention provides preparative purification of rna (e.g., mrna) using ion (e.g., anion) exchange chromatography that allows for separation of longer rnas up to 10,000 nucleotides in length via a scalable method.
Modema Therapeutics, Inc.


01/28/16
20160024139 

Rna purification methods


Methods for purifying rna from a sample, comprising one or more steps of tangential flow filtration, hydroxyapatite chromatography, core bead flow-through chromatography, or any combinations thereof. These techniques are useful individually, but show very high efficiency when used in combination, or when performed in particular orders.
Glaxosmithkline Biologicals Sa


01/21/16
20160020080 

Sample plate for maldi-tof mass spectrometer and manufacturing the sample plate and mass spectrometry method using the sample plate


The present invention relates to a sample plate to be used for a maldi-tof (matrix assisted laser desorption ionization time of flight) mass spectrometer, and more particularly, to a sample plate for a maldi-tof mass spectrometer, which is particularly useful for molecular weight measurement of a high-volatile material, a method of manufacturing the sample plate and a mass spectrometry method using the sample plate. Object of the present invention to provide a method capable of performing a mass spectrometry for a high-volatile material by using a maldi-tof mass spectrometer so as to overcome the limits of the gas chromatography method of the related art.
Industry-academic Cooperation Foundation, Yonsei University


01/21/16
20160018409 

Improved mapping glycans of glycoproteins


The use of anthranilic acid (2-aa) to label n-glycans prior to separation using a reversed-phase liquid chromatography (rp-lc) column under acidic conditions using formic acid is described herein. Negatively charged 2-aa offers stronger retention on the reversed phase column than 2-aminobenzamide (2-ab) in rp-lc and allows efficient ionization and detection of 2-aa labeled n-glycans.
Hexal Ag


01/21/16
20160018369 

Positioning guides and ion sources


Certain embodiments described herein are directed to inserts and ion sources. In some examples, an insert can comprise a positioning guide configured to provide for visual positioning of a chromatography column under the positioning guide.
Perkinelmer Health Sciences, Inc.


01/21/16
20160018367 

Matching thermally modulated variable restrictors to chromatography separation columns


Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatography column. A method for configuring a chromatography system with independent control of system pressure and mass flow rate of a compressible mobile phase includes determining a type of chromatography separation column to be used in the chromatography system, matching a thermally modulated variable restrictor to the type of chromatography separation column for use together during operation of the chromatography system, and bundling the chromatography column with its matching thermally modulated variable restrictor for distribution as a single package..
Waters Technologies Corporation


01/21/16
20160018366 

Thermally modulated variable restrictor


Thermally modulated variable restrictors used in chromatography systems enable independent control of system pressure and linear velocity of a compressible mobile phase passing through a chromatographic column. The restrictors include a restrictor body having a fluidic channel with an inlet that receives the mobile phase from the column and an outlet through which the mobile phase leaves the fluidic channel.
Waters Technologies Corporation


01/21/16
20160018365 

Functionalized metal oxides as a stationary phase and a surface template for micro gas chromatography separation columns


The present invention provides a detector and method for detecting substances in complex mixtures. The detector includes a microfabricated preconcentrator, a separation column with an on-chip thermal conductivity detector, a controller for controlling flow and thermal management and a user interface.

01/21/16
20160017397 

Monitoring a dynamic system by liquid chromatography-mass spectrometry


The present invention provides a method for monitoring of profile changes of components in a dynamic system such as a cell-free in vitro protein synthesis system by using liquid chromatography (lc) combined with mass spectrometry (ms). In an additional aspect, this invention provides a method for enhancing the yield and/or reproducibility in a cell-free protein synthesis system by modulating the level and/or activity of a protein component that has regulatory effects on the system..
Sutro Biopharma, Inc.


01/21/16
20160017313 

Analysis of mrna heterogeneity and stability


Reversed phase-high performance (high pressure) liquid chromatography (rp-hplc) and size exclusion chromatography (sec) methods have been developed for monitoring structural and size heterogeneity as well as stability of large rna transcripts, including lengths of up to at least 10,000 nucleotides. The methods are designed for significantly larger mrnas that could be monitored in the past, including lengths of up to at least 10,000 nucleotides, and including chemically modified rna transcripts.
Moderna Therapeutics, Inc.


01/21/16
20160017272 

Devices and methods for purification, detection and use of biological cells


This invention relates to devices and methods for purifying, detecting and using biological cells. A variety of cell types including viable tumor, stem, immune and sperm cells can be purified from a complex biological sample using a column, including a pipette tip column.

01/21/16
20160017147 

Curable resin composition and cured product thereof, encapsulant, and semiconductor device


The curable resin composition according to the present invention includes a polyorganosiloxane (a), an isocyanurate compound (b), and a silane coupling agent (c). The polyorganosiloxane (a) is an aryl-containing polyorganosiloxane.

01/21/16
20160017102 

Polycarbonate-polyorganosiloxane copolymer and producing same


Provided is a polycarbonate-polyorganosiloxane copolymer, including a specific polycarbonate block unit (a) and a specific polyorganosiloxane block unit (b), in which in a differential molecular weight distribution curve obtained from measurement of the polyorganosiloxane block unit (b) by gel permeation chromatography using the polystyrene calibration curve, the curve having an axis of abscissa indicating a logarithmic value log(m) of a molecular weight m and an axis of ordinate indicating dw/d log(m) obtained by differentiating a concentration fraction w with respect to the logarithmic value log(m) of the molecular weight, (1) a dw/d log(m) value becomes maximum in a range of 3.4≦log(m)≦4.0, and (2) in the differential molecular weight distribution curve, a ratio of a value obtained by integrating the dw/d log(m) value over a range of 4.0≦log(m)≦4.5 to a value obtained by integrating the dw/d log(m) value over the entire range of the log(m) is 6% or more and 40% or less.. .
Idemitsu Kosan Co., Ltd.


01/21/16
20160016877 

Simulated moving bed chromatographic separation process


The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous alcohol, wherein the apparatus has a plurality of zones comprising at least a first zone and a second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the pufa product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the pufa product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said pufa product being separated from different components of the feed mixture in each zone.. .
Basf Pharma (callanish) Limited


01/14/16
20160009868 

Block copolymer and production the same


A block comprised of a copolymer is obtained by ring-opening polymerization of a cyclic polyarylene sulfide, so that a block copolymer is produced to have a maximum peak molecular weight measured by size exclusion chromatography (sec) in a range of not less than 2,000 and less than 2,000,000 and have a unimodal molecular weight distribution in this range.. .
Toray Industries, Inc.


01/14/16
20160009762 

Chromatographic purification of antibodies from chromatin-deficient cell culture harvests


Methods for the improved purification of antibodies and other proteins from protein preparations including the steps of conditioning the protein preparation by contacting it with multivalent organic ions, then applying the conditioned preparation to an adsorptive chromatography medium.. .
Agency For Science, Technology And Research


01/14/16
20160007625 

Coffee drink


Provided is a coffee beverage, including the following components (a), (b), and (c): (a) at least one selected from the group consisting of catechol and pyrogallol; (b) 3,4-dicaffeoyl-1,5-quinolactone; and (c) chlorogenic acids, in which a ratio of a total peak area of the component (a) to a peak area of the component (b), ((a)/(b)), as determined by liquid chromatography-time of flight mass spectrometry (lc-tof/ms) of the coffee beverage, is from 0 to 2.0, and in which a content of the component (c) in the coffee beverage is from 0.05 to 2% by mass.. .
Kao Corporation


01/07/16
20160003797 

Method for detection of adenosine and metabolites thereof


This invention relates is a label-free, enzyme-free, aptamer-free method for simultaneously measuring adenosine, and its intracellular metabolites, e.g., amp, adp and atp, using high pressure liquid chromatography coupled to electrochemical detector (hplc-ecd).. .
St. Jude Children's Research Hospital


01/07/16
20160003788 

Uv light emitting diode as light source in gas chromatography-uv absorption spectrophotometry


An apparatus for analyzing a sample, including a sample receiving device, a gas chromatograph and a spectrophotometer, said spectrophotometer including a uv light emitting diode as the light source, an elongated chamber and a detector. The uv light source is arranged to illuminate sample substances conducted through the chamber, and the detector is arranged to identify sample substances by uv absorption spectroscopy..
Chromalytica Ab


01/07/16
20160003787 

Method and system for monitoring biomolecule separations by mass spectrometry


Monitoring biomolecule separations by mass spectrometry is described. The mixture to be separated is introduced into a first fluidic stream, which then passes through a chromatography column.
Microsaic Systems Plc


01/07/16
20160002696 

Method to identify bacterial species by means of gas chromatography/mass spectrometry in biological samples


Method to identify bacterial classes in a biological sample, in particular a urine sample, that provides to carry out an analysis by means of gas chromatography-mass spectrometry (gc/ms) of the volatile components, such as metabolites and catabolites, of the sample in order to identify a graphic plot characteristic of a specific bacterial class.. .
Alifax Holding Spa


01/07/16
20160002404 

Paving binder


A paving binder according to the present invention is used for a paving mixture for forming a pavement, including a polyamide resin having a weight average molecular weight, as measured by gel permeation chromatography of 2,000 or more and 10,000 or less and having an area, corresponding to a component having a molecular weight of 20,000 or more and 500,000 or less, of 0.5% or more and 12% or less of a total area in a chromatogram of molecular weight distribution as measured by gel permeation chromatography. Thus, tolerance for a severe temperature condition or loading condition can be improved, while ensuring convenience from the standpoint of laying such that the laying can be made by the conventional machine composition or laying system..
Kao Corporation


01/07/16
20160002290 

Materials and methods for removing endotoxins from protein preparations


A method includes (i) adding allantoin in a supersaturating amount to a protein preparation including a desired protein and at least one endotoxin as a contaminant, (ii) removing solids after the adding step to provide a sample for further purification by void exclusion chromatography on a packed particle bed of electropositive particles in a column, the packed particle bed having an interparticle volume, (iii) applying a sample volume to the packed particle bed, wherein the electropositive particles support void exclusion chromatography, and wherein the sample volume is not greater than the interparticle volume, and (iv) eluting a purified sample including the desired protein and a reduced amount of the endotoxin. The method is optionally carried out with only the allantoin treatment or only the void exclusion chromatography..
Agency For Science, Technology And Research


01/07/16
20160002289 

Method of purifying an antibody


A method of purifying an antibody composition comprises application of anion exchange chromatography late in the purification process. An ultrafiltration/diafiltration-purified antibody composition is subjected to anion exchange chromatography (aex) to form a pharmaceutically-pure antibody composition..
Synthon Biopharmaceuticals B.v.


01/07/16
20160001198 

Mobile phase degassing for nano-flow liquid chromatography


Systems and methods for degassing liquids in nano-flow liquid applications (fig. 3).
The Translational Genomics Research Institute


01/07/16
20160000922 

Functionalised triblock copolymers and compositions containing such polymers


Amphiphilic triblock copolymers b-a-b, wherein a is a linear poly(ethylene glycol) block, having a number average molecular weight (mn) of between 900 and 3000 daltons, determined with size exclusion chromatography; wherein b are hydrophobic blocks with at least two cyclic monomers selected from the group consisting of glycolide, lactide, 1,3-dioxan-2-one, 5,5-dimethyl-1,3-dioxan-2-one, 1,4-dioxan-2-one, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one, each b-block having a number average molecular weight (mn) of between 400 and 2000 daltons, determined with size exclusion chromatography; and wherein 25% to 100% of the polymer hydroxyl end-groups are covalently modified with at least one derivative of a c2-c20 fatty acid. The invention also relates to compositions with such polymers and the use thereof..
Ingell Technologies Holding B.v.


12/31/15
20150377869 

Purification of nanoparticle-antibody conjugates


Methods of purifying antibody-nanoparticle conjugates with size exclusion chromatography are provided.. .
Bio-rad Laboratories, Inc.


12/31/15
20150377847 

Thin layer chromatography plates and related methods


In an embodiment, a method for manufacturing a thin layer chromatography (“tlc”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating.
Brigham Young University


12/31/15
20150377846 

Measurement method, measurement apparatus, and eluent


Provided is a method of measuring at least one kind of hemoglobin, selected from abnormal hemoglobin, or hemoglobin that is a marker for thalassemia, the method comprising: performing high-performance liquid chromatography, using: an eluent l that contains a phosphoric acid monohydrogen dialkali metal salt (component 1) and a phosphoric acid dihydrogen monoalkali metal salt (component 2) as components, and that has a content of component 1 of from 0.08% by mass to 0.50% by mass with respect to a total mass of the eluent l, a content of component 2 of from 0.04% by mass to 1.2% by mass with respect to a total mass of the eluent l, and a ratio of component 2/component 1 of from 0.4 to 10.. .
Arkray, Inc.


12/31/15
20150377845 

Fully automated analytical determination of chloroethers in water and urine sample


A fully automated flow assisted-solid-phase microextraction (fa-spme) is developed for the determination of chloroethers in aqueous samples. A ctc combipal autosampler coupled with gas chromatography-mass spectrometry (gc-ms) is used to automate the extraction process.
King Abdulaziz City For Science And Technology


12/31/15
20150377752 

Determination of polycyclic aromatic hydrocarbons in water using nanoporous material prepared from waste avian egg shell


Nanoporous polymorphic crystals of caco3 were used as sorbent and were applied in the dispersive micro-solid-phase extraction of selected polycyclic aromatic hydrocarbons as target analytes. After separation of the analytes on gas chromatography, they were successfully quantified with external calibration using flame ionization detection.
King Fahd University Of Petroleum And Minerals


12/31/15
20150376363 

Porous material, producing method thereof, and serial producing apparatus thereof


Provided is a porous material made of at least an aliphatic polyester resin or an aliphatic polycarbonate resin, and having a porosity of 70% or higher, wherein a polystyrene equivalent weight average molecular weight of the resin measured by gel permeation chromatography is 300,000 or greater.. .
Ricoh Company, Ltd.


12/31/15
20150375223 

Disposable tip for pricking septum of a sample vial for sample preparation and/or analysis.


This invention relates to a disposable pipette tip or tube designed to perform biological or chemical sample preparation, purification or separation where the samples are in a closed bottle with a lid with septum or membrane. In an automatic sampler for hplc or gas chromatography, septum closed vials are used to prevent samples from drying out or evaporating during the analytical process.

12/24/15
20150369781 

Mems flow control chip for gas chromatography


A micro-electro-mechanical system (mems) flow control chip that can control the flow of gas and be configured to operate in a gas chromatography system are disclosed. The mems flow control chip can include at least one inlet port in the chip, at least one outlet port in the chip, at least one flow channel between the inlet and outlet ports, and at least one pneumatic valve in the chip for controlling a flow of gas through the flow channel and between the inlet port and outlet ports.
The Penn State Research Foundation


12/24/15
20150368514 

Curable resin composition and cured product thereof, encapsulant, and semiconductor device


The curable resin composition according to the present invention includes a polyorganosiloxane (a), an isocyanurate compound (b), and a silane coupling agent (c). The polyorganosiloxane (a) is an aryl-containing polyorganosiloxane.

12/24/15
20150368429 

Polyester modifier composition for cellulose ester resin, cellulose ester optical film, and polarizing plate protective film


There is provided a polyester modifier composition for a cellulose ester resin, including: a polyester resin produced by a reaction between a diol and 1,2-dicarboxycyclohexane. The modifier composition has a number-average molecular weight (mn) in the range of 350 to 2,000 as measured by gel permeation chromatography (gpc).
Dic Corporation


12/24/15
20150367253 

Photoluminescent thin-layer chromatography plate and methods for making same


In an embodiment, a method for manufacturing a chromatography apparatus such as a thin layer chromatography (“tlc”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the oxidized elongated nanostructures with a coating.
Brigham Young University


12/17/15
20150362506 

A determining glycosylation and terminal modification of samples during protein purification process


The present invention provides a method for determining glycosylation and terminal modifications of immunoglobulin during immunoglobulin purification process, which can simultaneously and rapidly determine glycosylation, n-terminal pyroglutamination and c-terminal de-lysination of immunoglobulin. The method comprises: 1) separating immunoglobulin by using cation-exchange resin, and collecting different components in according to retention time; 2) denaturing the components of immunoglobulin obtained in step 1) with a denaturant, followed by reducing them with a reducing agent, to separate the light chain and heavy chain; 3) separating the light chain and heavy chain of immunoglobulin of step 2) by using reverse phase ultrahigh pressure liquid chromatography; 4) measuring the molecular weights of the light chain and heavy chain obtained in step 3) with mass spectrum; 5) analyzing the chromatographic data obtained in step 3) and the mass spectrometric data obtained in step 4) to determine glycosylation and terminal modifications of said immunoglobulin..
Livzon Mabpharm Inc.


12/17/15
20150361214 

Polylactic acid composition, and production method and production apparatus of the same


To provide a polylactic acid composition, containing: polylactic acid, wherein the polylactic acid composition contains a ring-opening polymerizable monomer residue in a concentration of 100 ppm by mass to 5,000 ppm by mass, and wherein the polylactic acid composition has a weight average molecular weight of 100,000 or more but less than 300,000 as measured by gel permeation chromatography, a yellow index (yi) value of 5 or less, and a charpy impact strength of 10 kj/m2 or more.. .
Ricoh Company, Ltd.


12/17/15
20150361213 

Polymer product and production method thereof, and polymer product producing apparatus


Provided is a polymer product, in which the weight average molecular weight measured by gel permeation chromatography is 250,000 or greater and the content of residual ring-opening-polymerizable monomer is 100 ppm by mass or greater but less than 1,000 ppm by mass, or a polymer product, in which the content of residual ring-opening-polymerizable monomer is from 1,000 ppm by mass to 20,000 ppm by mass and the yellow index (yi) value is 15 or less.. .

12/17/15
20150361129 

Methods for increasing the capacity of flow-through processes


In various embodiments, the present invention provides a process for separating target proteins from non-target proteins in a sample comprising increasing the concentration of the target proteins and non-target proteins in the sample and subsequently delivering the concentrated sample to a chromatography device. In other embodiments, the invention relates to a process for increasing the capacity of a chromatography device for a target protein by delivering a concentrated sample comprising the target protein to a chromatography device..
Emd Millipore Corporation


12/17/15
20150361128 

Methods of using ion exchange chromatography to control levels of high mannose glycoforms


Provided are methods of using ion exchange based chromatography to control the levels of high mannose glycoforms in a glycoprotein sample, such as an antibody sample. The high mannose glycoforms can be removed from the sample or isolated and enriched.
Medimmune, Llc


12/17/15
20150360146 

Purification of organic compounds using surrogate stationary phases on reversed phase columns


There are only two ways to increase the amount of sample that can be purified by preparative reversed phase high performance liquid chromatography (prep-rp-hplc) in a single run: (1) the traditional approach is to use a bigger column (greater amount of stationary phase); and (2) use displacement chromatography which uses the stationary phase more effectively. This invention describes a unique prep-rp-hplc technique that uses a c-18/c-8 derivatized silica coated with a hydrophobic quaternary ammonium salt or quaternary phosphonium salt to result in 7 to 12 fold increase in sample loading (of the crude mixture of organic compounds including synthetic crude peptides) in contrast to the conventional prep-rp-hplc technique.
Neuland Health Sciences Private Limited


12/17/15
20150360145 

Chromatography system with tilt-prevention structure and associated process


chromatography apparatus and methods are described, especially for expanded bed adsorption. A column tube has a process fluid input device at the bottom and a movable piston in the top.
Biotechflow Limited


12/10/15
20150355192 

A novel affinity peptide library of igg constructed based on protein a affinity model and the application of the design method thereof


An affinity ligand peptide library of igg constructed on the basis of protein a affinity model and the application of a design method thereof according to the molecular mechanics—poisson-boltzmann surface area (mm/pbsa) method and on the basis of the known human igg-protein a complex structure, the hot spots of protein a that have high affinity for human igg are obtained analytically, and a protein a simplified affinity model is built thereof. An affinity peptide library of igg is constructed including heptapeptide and octapeptide structural modes.
Tianjin University


12/10/15
20150355149 

Method and device for carrying out thin-layer chromatography


The invention relates to a method for carrying out thin-layer chromatography in which a liquid sample is applied to a separating layer (14), in which a mobile phase is subsequently applied to the separating layer (14) and brought into contact with the sample, and in which, after a development phase, a thin-layer chromatogram is produced, the liquid sample is taken up from a sample storage container (11, 12, 13) with the aid of an autopipette (4) using a new pipette tip (8, 9) for each sample application operation and applied to the separating layer (14). The invention further relates to a device (5) which is suitable for carrying out the method..
Merck Patent Gmbh


12/10/15
20150353904 

Methods for purification of arysulfatase a


The present invention provides, among other things, improved methods for purifying arylsulfatase a (asa) protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant asa protein can be purified from unprocessed biological materials, such as, asa-containing cell culture medium, using a process involving as few as four chromatography columns and only one step of post-chromatographic ultrafiltration/diafiltration..
Shire Human Genetic Therapies Inc.


12/10/15
20150353599 

Method for purifying recombinant fsh


The present invention relates to a method for purifying a recombinant follicle stimulating hormone (fsh) or recombinant fsh variant. The method comprises the steps of subjecting a liquid containing a recombinant fsh or recombinant fsh variant to an anion exchange chromatography, to a hydrophobic interaction chromatography, and to a dye affinity chromatography, wherein these chromatographies may be performed in any order, and wherein the method neither comprises a weak anion exchange chromatography nor a reverse phase chromatography.
Biogenerix Ag


12/10/15
20150353598 

Enhanced purification of antibodies and antibody fragments by apatite chromatography


Methods are disclosed for use of apatite chromatography, particularly without reliance upon phosphate gradients, for purification or separation of at least one intact non-aggregated antibody, or at least one immunoreactive antibody fragment, from an impure preparation. Integration of such methods into multi-step procedures with other fractionation methods are additionally disclosed..
Bio-rad Laboratories, Inc.


12/10/15
20150352465 

Chromatography media for purifying vaccines and viruses


Adsorptive media for chromatography, particularly ionexchange chromatography, derived from a shaped fiber, useful for purifying viruses. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers.
Emid Millipore Corporation


12/03/15
20150346169 

Method of and device for packing a chromatography column


A method and device for packing a chromatography column formed of one or more vibration devices attached to top and/or bottom flanges of the column. Media is added in one or more steps to the column, allowed to settle under the effects of gravity and then subjected to one or more treatments of vibration from the vibration devices until a suitably packed column is obtained.
Emd Millipore Corporation


12/03/15
20150346168 

Solvent delivery system for liquid chromatography that maintains fluid integrity and pre-forms gradients


A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery.
Waters Technologies Corporation


12/03/15
20150346068 

Reaction vessel for sample preparation


The present invention relates to sample preparation container for purification and/or enrichment of bio-organic compounds from cellular material, viruses and/or sub-components of said cellular material and/or viruses, the container comprising a reaction chamber and a chromatography medium; wherein said reaction chamber is for holding said cellular material, viruses and/or sub-components of said cellular material and/or viruses and is configured such that at least one of the following reactions can be performed therein: lyis, e.g. By sonication and/or boiling; chromatographic purification; reduction; alkylation; and enzymatic reactions such as proteolysis; wherein said chromatography medium is configured to purify and/or enrich said bio-organic compounds; wherein (a) said chromatography medium is located at a wall of said reaction chamber, and said wall is closed or sealed and configured to be opened for obtaining purified and/or enriched bio-organic compounds; or (b) said sample preparation container further comprises a receiving chamber for receiving said bio-organic compounds, said receiving chamber being adjacent to said chromatography medium such that said chromatography medium separates said reaction chamber from said receiving chamber, and the outer face of said receiving chamber is closed and configured to be opened for obtaining purified and/or enriched bio-organic compounds..
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.


12/03/15
20150344808 

Lubricating oil composition and additive therefor having improved wear properties


A compression-ignited engine lubricant and a method for reducing engine wear. The lubricant including, (a) a base oil; (b) oleamide; (c) zinc dihydrocarbyl dithiophosphate; and (d) a functionalized dispersant.
Afton Chemical Corporation


12/03/15
20150344564 

Viral inactivation during purification of antibodies


Described herein are methods for isolating and purifying antibodies from a sample matrix. One aspect of the present disclosure is directed to viral reduction/inactivation of samples generated in the various steps of antibody purification.
Abbvie Inc.


12/03/15
20150344520 

Chromatography media and protein purification method using the same


A chromatography media having excellent salt tolerance, adsorption characteristics and so forth is provided. The chromatography media contains a base media involving porous particles and polyamine bonded with the base media, in which 20 to 40% of amino groups in the polyamine is modified with a hydrophobic group..
Jnc Corporation


12/03/15
20150344397 

Method for purifying carboxylic acids from fermentation broths


Method and devices for separating and purifying carboxylic acids from fermentation broths comprising carboxylic acid ammonium salts are disclosed herein. The method includes (a) removing biomass and any solids present from the fermentation broth; (b) preparing a solution comprising the desired carboxylic acid and an additional solution comprising ammonium salts, by carrying out simulated moving bed chromatography (smb); (c) ultra-purifying the solution comprising the desired carboxylic acid from method step (b); (d) concentrating the purified carboxylic acid solution from method to step (c); (e) crystallizing the concentrated carboxylic acid solution from method step (d); and (f) concentrating the additional solution comprising ammonium salts from method step (b).
Thyssenkrupp Industrial Solutions Ag


12/03/15
20150343326 

Thin layer chromatography plates


In an embodiment, a method for manufacturing a thin layer chromatography (“tlc”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), priming the elongated nanostructures with one or more adhesion priming layers, and at least partially coating the elongated nanostructures with a coating.
Brigham Young University


11/26/15
20150340216 

High mass accuracy filtering for improved spectral matching of high-resolution gas chromatography-mass spectrometry data against unit-resolution reference databases


The invention provides methods, systems and algorithms for identifying high-resolution mass spectra. In some embodiments, an analyte is ionized and analyzed using high-resolution mass spectrometry (ms) at high mass accuracy (such as ≦75 ppm or ≦30 ppm) and the obtained mass spectra are matched with one or more prospective candidate molecules or chemical formulas.
Wisconsin Alumni Research Foundation


11/26/15
20150338383 

Frits for chromatography


Frits for use in analytical instrument systems, including liquid chromatography systems, particularly hplc and uhplc systems, and methods of making and using the frits, are provided. The frits can have multiple layers, which may have different surface finishes on different surfaces..
Idex Health & Science Llc


11/26/15
20150338348 

Ultrasensitive sers flow detector


The invention provides an apparatus and methods for label-free, chemical specific detection in flow for high throughput characterization of analytes in applications such as flow injection analysis, electrophoresis, and chromatography. A surface-enhanced raman scattering (sers) flow detector capable of ultrasensitive optical detection on the millisecond time scale has been developed.
University Of Notre Dame Du Lac


11/26/15
20150338000 

Plug unit and connection system for connecting capillary tubes


A plug unit and system for connecting capillary tubes, especially for high-performance liquid chromatography, with a plug capillary tube projecting through a hole of a plug housing, which is detachably connectable to a bushing unit. The plug capillary tube front end projects into a capillary tube receptacle in the bushing unit with its end face essentially aligned opposite a front end of a bushing capillary tube or a bushing capillary tube opening of the bushing unit, the end face of which is butted against.
Dionex Softron Gmbh


11/26/15
20150337386 

Test composition for screening cancers


Provided in the present invention are a molecule for biomarking cancers and a test composition for screening cancers and a detection method thereof comprising designing a number of oligonucleotide primers or probes by analyzing specimens for methylated regions of targeted genes pax1, znf582, sox1 and nkx6-1 in physical examination, and then using the oligonucleotide probes to detect whether methylation exists in the target genes, and further judge the likelihood of the occurrence of cancer. The detection methods for methylation status include methylation-specific pcr, (msp), quantitative methylation-specific pcr (qmsp), bisulfate sequencing (bs), microarrays, mass spectrometer, denaturing high-performance liquid chromatography (dhplc), pyrosequencing, and enzyme-linked immunosorbent assay (elisa)..
Istat Biomedical Co., Ltd.


11/26/15
20150337281 

Method for production of botulinum toxin


A method of making botulinum toxin comprises treating a culture of a botulinum toxin-producing strain with acid to precipitate a botulinum toxin; adding buffer to the precipitated botulinum toxin, followed by treatment with a protease inhibitor and nuclease, thereby extracting the botulinum toxin; treating the extracted botulinum toxin with acid to precipitate the botulinum toxin and dissolving the precipitate in buffer; and purifying the botulinum toxin by anion exchange chromatography. The use of the method makes it possible to produce a high-purity botulinum toxin by a simple process.
Daewoong Co., Ltd.


11/26/15
20150336872 

Process for the purification of carboxylic acids


A process for the purification of carboxylic acid having a chain length from one to five carbon atoms is disclosed herein. The process includes transforming the carboxylic acid to its monoester and/or its diester, and processing the mono- and/or the diester of the carboxylic acid by subcritical or supercritical fluid chromatography using a subcritical or supercritical mobile phase..
Thyssenkrupp Ag


11/26/15
20150336860 

Method for isolating diamondoids


Method for separating the diamondoids by liquid chromatography from a sample of iso-alkanes and cycloalkanes, or from a mixture of organic compounds, this method comprising introducing the sample into a column comprising a stationary phase comprising a material capable of forming inclusion complexes with the diamondoids, eluting with an eluent, and collecting the eluted fraction.. .
Total S.a.


11/26/15
20150336027 

Chromatography column and conducting maintenance on a chromatography column


A chromatography column including: a tubular housing; a first end unit removably connected to a first end of the tubular housing; a second end unit removably connected to a second end of the tubular housing; an adaptor assembly movable within said tubular housing; an adaptor rod connected to said adaptor assembly, which adaptor rod is arranged to extend through an opening in the first end unit; a filter removably connected to the adaptor assembly; and a frame connected to said tubular housing for supporting the column on a floor. At least an actuating means is arranged on the frame, so that the column can be lifted and lowered in a substantially vertical direction..
Ge Healthcare Bio-sciences Ab


11/26/15
20150336026 

Purge low pressure gradient formation liquid chromatography


Described is a method for purging a fluid channel is a low pressure gradient formation liquid flow system. Control of the fluid channels for multiple solvents allows for one or more static volumes of solvents not intended for use in an isocratic flow to be purged from their fluid channels to avoid contamination of the isocratic solvent.
Waters Technologies Corporation


11/19/15
20150331001 

Methods and the analysis of fatty acids


Exemplary embodiments of the present disclosure relate to co2-based chromatography for the efficient and precise separation of fatty acids. The present disclosure is based, in part, on the discovery that a co2-based chromatography system with features, such as, e.g., improved pressure stability, improved sample injection, and superior column packing materials, reproducibly resolve fatty acids..
Waters Technologies Corporation


11/19/15
20150330956 

Flame ionization detection burner assemblies for use in compressible fluid-based chromatography systems


The present disclosure relates to burner assemblies of flame-based detectors. These burner assemblies are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation..
Waters Technologies Corporation


11/19/15
20150330955 

Low-power miniature led-based uv absorption detector with low detection limits for capillary liquid chromatography


A system and method for performing uv led-based absorption detection for capillary liquid chromatography for detecting and quantifying compounds in a liquid, wherein a simplified system eliminates the need for a beam splitter and a reference cell by using a stable uv source, and power requirements are reduced, resulting in a portable and substantially smaller system with relatively low detection limits.. .
Brigham Young University


11/19/15
20150330887 

Apparatus and microparticle separation based on microfluidic chromatography using surface acoustic wave


The present invention related to an apparatus for separating micro-nano scale particles based on microfluidic chromatography using surface acoustic waves, comprising: a piezoelectric substrate; a pair of transducers, which are patterned on the piezoelectric substrate and generate surface acoustic waves when electric energy is applied to the piezoelectric substrate; a microfluidic chip, which is mounted on the piezoelectric substrate and include a microfluidic channel disposed between the pair of transducers, wherein a fluid including micro-nano scale particles flows in the microfluidic channel; and a detection unit, which detects micro-nano scale particles separated by the surface acoustic waves while the micro-nano scale particles pass through the microfluidic channel, wherein forces of the surface acoustic waves generated by the pair of transducers are formed in a direction opposite to a fluid flow to generate flow resistance to the micro-nano scale particles which flows in the microfluidic channel.. .
Korea University Research And Business Foundation


11/19/15
20150329713 

Dispersion stabilizer for suspension polymerization and vinyl resin production method


There is provided a dispersion stabilizer for suspension polymerization comprising a vinyl alcohol polymer (a), wherein the vinyl alcohol polymer (a) has a terminal anionic group and has a saponification degree of 30 to 60 mol %, a viscosity average polymerization degree of 650 or less, and a proportion of polymer molecules having a molecular weight of 8000 or less as determined by gel permeation chromatography is 9.5% by mass or less. When a vinyl compound is suspension-polymerized using the dispersion stabilizer for suspension polymerization, its higher polymerization stability allows for providing particles having a uniform size with a less amount of coarse particles, even under the conditions favorable for unstable polymerization..
Kuraray Co., Ltd.


11/19/15
20150329618 

Chromatographic isolating and purifying high-purity recombined human serum albumin


Disclosed is a chromatographic method for isolating and purifying high-purity recombined human serum albumin, comprising: conducting cation-exchange chromatography on recombined human serum albumin, and adding alcohol to a buffer solution to remove endotoxin, so as to obtain a primary product i; under binding conditions, conducting anion/hydrophobic composite resin exchange chromatography on the primary product i to obtain an intermediate product ii; conducting hydrophobic chromatography on the intermediate product ii to obtain the target product, the purified high-purity recombined human serum albumin. The purity of the recombined human serum albumin obtained by isolating and purifying with the chromatographic method of the present invention is greater than 99.9999%, and the content of the endotoxin meets the criteria stipulated by chinese pharmacopoeia..
Wuhan Healthgen Biotechnology Corp


11/19/15
20150329612 

Process for purifying insulin and analogues thereof


A process is described for purifying insulin and insulin analogues that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed under low to moderate pressure at an elevated temperature.. .
Merck Sharp & Dohme Corp.


11/19/15
20150329588 

Protein purification using displacement chromatography


Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to compositions and methods for isolating and purifying proteins incorporating a displacement chromatographic step.
Abbvie, Inc.


11/19/15
20150328564 

Method for separating iso-alkanes and cycloalkanes from an oil


Method for the processing of a mixture of organic compounds, in particular of an oil, in order to recover different constituents therefrom. This method makes it possible to separate a fraction of iso-alkanes and cycloalkanes from a sample of a mixture of organic compounds, said method comprising a separation step by liquid chromatography..
Total Sa


11/19/15
20150328563 

Method for cleaning of packed bed chromatography columns


The invention discloses a process for chromatographic separation of at least one target biomolecule from at least one contaminant, comprising the steps of: a) providing an axial chromatography column comprising a consolidated bed of separation matrix particles, where the consolidated bed is confined between a bottom support net and a movable top adaptor; b) separating a target biomolecule from at least one contaminant on the column; c) raising the adaptor by at least 10% of the height of the consolidated bed; d) flowing a cleaning liquid upwards through the bed under conditions sufficient to liquefy the bed, and; e) repacking the matrix particles of the liquefied bed to create a consolidated bed and lowering the adaptor such that it contacts the packed bed and optionally compresses it, and; f) separating a target biomolecule from at least one contaminant on the column.. .
Ge Healthcare Bio-sciences Ab


11/12/15
20150323526 

Immunochromatography devices, methods, and kits


A membrane-based assay device, methods and kits for determining the presence or quantity of an analyte in a test sample are provided. The immunochromatographic device comprises a membrane having a capture antibody bound thereto at a test zone, wherein the capture antibody is capable of binding with an analyte, in particular a z-aat protein present in a sample from a piz gene carrier..
Grifols Therapeutics, Inc.


11/12/15
20150323509 

Establishing fluidic connections between chromatography components


A clamp assembly includes a rail configured to receive a first fluidic assembly, and a carriage slidably mounted to the rail and configured to receive a second fluidic assembly. The carriage is operable to establish a first fluid tight seal between the first fluidic assembly and a chromatography column received within the clamp assembly, and to establish a second fluid tight seal between the second fluidic assembly and the chromatography column..
Water Technologies Corporation


11/12/15
20150321121 

An adaptor for a chromatography column


An adaptor for a chromatography column, the adaptor comprising a substantially circular bottom plate provided with an end surface; a ring shaped wall element arranged at the periphery of the bottom plate. The bottom plate and the wall element having a common axis and the adaptor is provided with a filter connection arrangement for removably connecting a filter on the end surface of the bottom plate of the adaptor..
Ge Healthcare Bio-sciences Ab




Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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