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|| List of recent Chromatography-related patents
| Zwitterionic stationary phase for hydrophilic interaction liquid chromatography and preparation method thereof|
A type of liquid chromatographic stationary phase and preparation method thereof, the bonding terminal of the chromatographic stationary phase is zwitterionic functional group. The preparation method includes the following steps, alkenyl or alkynyl silane is bonded onto the surface of silica based on the horizontal polymerization approach to obtain alkenyl- or alkynyl-modified silica.
| Ethylene-a-olefin copolymer and article|
The present invention rerates to an ethylene-α-olefin copolymer comprising monomer units derived from ethylene and monomer units derived from an α-olefin having 3 to 20 carbon atoms, wherein the ethylene-α-olefin copolymer has a density of 860 to 950 kg/m3, a melt flow rate of 0.1 to 20.0 g/10 minutes, a ratio of a weight average molecular weight to a number average molecular weight measured by gel permeation chromatography of 2.0 to 3.5, a swell ratio of 2.0 to 2.8, and an activation energy of flow of 31.0 to 35.0 kj/mol.. .
| Rubber composition and tire produced by using the same|
A rubber composition containing 100 parts by mass of a rubber component (a) comprising at least one rubber of natural rubber and synthetic diene base rubbers and 5 to 120 parts by mass of a low molecular weight aromatic vinyl compound-diene compound copolymer (b) having a weight average molecular weight (measured by gel permeation chromatography and reduced to polystyrene) of 1,000 to 300,000 and, wherein the copolymer (b) comprises 0 to 80% by mass of an aromatic vinyl compound and has a vinyl bond content of 0 to 80% by mass in the part of the diene compound, and has a cross-linkable functional group at an end. Further, tires produced by using the rubber composition are provided..
| In situ restoration of apatite-based chromatography resins|
Methods and compositions are provided for treatment of an apatite-based resin from which retained solutes have been eluted by an elution buffer that contains an alkali metal salt with solutions of calcium ion, phosphate ion, and hydroxide separately from any sample loading and elution buffers. The treatment solutions restore the resin, reversing the deterioration that is caused by the alkali metal salt in the elution buffer..
| Liquid chromatography apparatus, liquid chromatography analysis method, and liquid chromatography analysis program|
A liquid chromatography apparatus having: a column that adsorbs analysis components within a specimen; a plunger pump that feeds eluent a, that elutes the analysis components adsorbed at the column, in an amount greater than or equal to an amount needed for analysis of one specimen from a cylinder portion by a one-time pushing operation of a rod; a photometric unit that analyzes analysis components eluted by eluent a; an eluent loop that holds eluent b; a liquid feeding flow path that communicates the plunger pump and the column; and a first switching valve that switches the liquid feeding flow path to either of a first flow path, that causes eluent a to flow from the plunger pump to the column, and a second flow path, that causes eluent a to flow from the plunger pump through the first eluent holding loop to the column, is provided.. .
| Bubble reduction device, chromatography device, bubble reduction method, and bubble reduction program|
A bubble reduction device, chromatography device, bubble reduction method and bubble reduction program capable of reducing bubbles in an eluent. Included are a liquid accommodation portion, a liquid supply apparatus, an air layer formation apparatus, a first channel and an evacuation portion.
| Channel bubble reduction device, channel bubble reduction method, and chromatography device|
A channel bubble reduction device includes a liquid accommodation portion, that accommodates a liquid, a liquid supply apparatus that, with a pushing operation of a rod, discharges the liquid through an aperture portion of a tube portion, a first channel that connects the aperture portion of the liquid supply apparatus with the liquid accommodation portion, and an air layer formation apparatus that forms an air layer in at least one of the first channel or the tube portion.. .
|Method for the purification of prostaglandins|
The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method..
|Organic-inorganic hybrid chiral sorbent and process for the preparation thereof|
The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. Racemic mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2′-dihydroxy-1,1′-binaphthalene (binol) and cyano chromene oxide with excellent chiral separation (enantiomeric excess, 99%) in case of mandelic acid under medium pressure column chromatography.
|Alpha-olefin polymer and method for producing the same|
An α-olefin polymer satisfying the following (1) to (4): (1) the average carbon-atom number of α-olefins constituting the polymer is 6.0 or more and 14 or less; (2) the molecular weight distribution (mw/mn)≦2.0; (3) 3000≦weight average molecular weight (mw)≦600000; and (4) (log10 mp-log10m1)−(log10m2-log10mp)≧0.2; wherein, in a chart measured by gel permeation chromatography, m1 is the molecular weight at the starting point of the peak, mp is the molecular weight at the peak top; and m2 is the molecular weight at the end point of the peak.. .
|Method for producing polymer particles, and polymer particles|
Provided are polymer particles which can be used at a high flow rate when used as a filler for chromatography, that is, has excellent resistance flow rate appropriate for processing in large quantities, and also has a high binding capacity for target molecules such as proteins when an appropriate ligand is contained in the particles, and a method for producing the polymer particles; specifically, crosslinked polymer particles and a method for producing the crosslinked polymer particles, polysaccharide composite particles and a method for producing the polysaccharide composite particles, a filler for chromatography using the polymer particles, and an adsorbent for antibody purification. Disclosed are: a.
|Method for the purification of a glycan and/or a glycoconjugate by chromatography using a stationary phase comprising cotton|
A method of purifying a glycan and/or a glycoconjugate comprising the steps of: (a) providing a stationary phase that comprises cotton; (b) applying a glycan and/or glycoconjugate-containing sample to the stationary phase; (c) washing the stationary phase with a first solvent; and (d) eluting the glycan and/or glycoconjugate from the stationary phase with a second solvent. A kit for purifying a glycan and/or glycoconjugate, the kit comprising: a stationary phase comprising cotton; and instructions for purifying a glycan and/or glycoconjugate according to the disclosed method..
|Rapid and high-throughput analysis of sterols/stanols or derivatives thereof|
This invention relates to a rapid, high-throughput process for analyzing one or more sterols/stanols or derivatives thereof in a plurality of samples. The method comprises the steps of introducing a plurality of samples containing one or more sterols/stanols or derivatives thereof into individual vessels in a multi-vessel plate; cleaving the one or more sterols/stanols or derivatives thereof of each sample in the multi-vessel plate to form free sterols/stanols; extracting the free sterols/stanols of each sample by solid phase extraction; and detecting the level of the extracted free sterols/stanols in each sample by liquid chromatography tandem mass spectrometry.
|Process and apparatus for rapid, high-throughput analysis of fatty acids|
This invention relates to an apparatus and a process for rapid, high-throughput analysis of fatty acids in a plurality of samples. The apparatus comprises at least one multi-vessel plate, wherein each vessel is a unit for holding a sample, or mixing and/or reacting a sample with one or more solvents or reagents; at least one matching multi-cap mat capable of sealing the vessels of the multi-vessel plate during the holding, mixing and/or reacting the sample; at least one multi-vessel plate holder having sealing units, whereby the multi-vessel plate holder, when the sealing units are engaged, presses the matching multi-cap mat onto the tops of the vessels in the multi-vessel plate sealing the vessels, so as to withstand high pressure and high temperature conditions.
|Method and apparatus for improved resolution chromatography|
An apparatus and a method are provided for column chromatography, which provide improvements in separation resolution and detection sensitivity, comprising a chromatography column having an inlet and an outlet, wherein the inlet is configured to introduce a flow of mobile phase into the column carrying a sample, wherein the inlet is further configured to introduce the flow of mobile phase into the column in at least two separate portions which are independently controllable, and to introduce the portions into different radial regions of the column, such that the portions flow longitudinally through the column in different radial regions. The sample preferably is contained in one of the portions, especially a central portion, in a higher concentration than in the other portion(s).
|Inline filter housing assembly|
A novel filter housing assembly for use in liquid chromatography and similar fluid flow based systems capable of use at high pressure, well above 1000 psi, is disclosed. The filter housing assembly has a very low dead volume of approximately 11 μl and is capable of holding brittle ceramic filter membranes as well as flexible membranes without the support of a fit.
|Co2-removal device and method|
An electrolytic co2-removal device for anion analysis of a liquid sample. The device includes a basic chamber and co2-permeable tubing in the basic chamber.
|Novel method for analyzing glycosaminoglycan|
A method of analyzing a sugar chain by high performance liquid chromatography uses a column packed with a stationary phase including anion and cation exchangers. A fluorescence-labeled sample is prepared for the analysis by decomposing glycosaminoglycans to be analyzed into their constitutional units being disaccharides, capturing the disaccharides by glycoblotting, releasing the disaccharides by acid treatment, and subsequently reductively aminating the released disaccharides.
|Antibody purification via affinity chromatography|
Embodiments herein provide methods of purifying monoclonal and polyclonal anti-bodies (e.g., immunoglobulins) from biological fluids, such as cell lysates, cell supernatant and ascites fluids, using small molecule affinity chromatography. Various embodiments disclose a class of small molecules that selectively bind a nucleotide binding site that is inherent to all immunoglobulins, and in various embodiments, methods are disclosed that use one of these small molecules as a capture molecule in small molecule affinity chromatography.
|Chromatography column support|
Herein is reported the use of a chromatography column support comprising at least one plane of symmetry, one axis of symmetry, at least three legs, at least three straight connectors, whereby the connectors define a plane that is perpendicular to the axis of symmetry of the support, whereby the connectors are connected to each other at the axis of symmetry, whereby each leg is connected to a connector, whereby each leg is perpendicular to the plane defined by the connectors, whereby all legs are on the same side of the plane defined by the connectors for stabilizing the packing of a chromatography column.. .
|Method and apparatus for reaction chromatography|
An apparatus for reaction chromatography comprising: a chromatography column, the column having a fluid outlet for an eluate flow, wherein the fluid outlet is configured with two or more fluid ports, the two or more fluid ports comprising one or more reactant ports, wherein each reactant port is for connecting a reactant flow into the eluate flow to react with the eluate flow, and one or more product ports for receiving the reacted eluate flow; one or more reactant sources in fluid communication with the one or more reactant ports to provide the reactant flow; and one or more processing units in fluid communication with the one or more product ports to process the reacted eluate flow.. .
|Improved method of analysing gas chromatography data|
A method of analysing gas chromatography data is described. The method, a first response factor data set acquired from a gas chromatograph (gc) apparatus during a procedure on a calibration or reference gas sample at a first time is received.
|Automatically controlling a plurality of devices of a separation and detection process for quantitative sample analysis|
A control system (1) for automatically controlling a plurality of devices (2) of a separation and detection process for quantitative sample analysis and according computer program. Such systems and computer programs can be used to operate quantitative sample analysis devices such as for example high performance liquid chromatography (hplc) devices or the like..
|Method of producing bacteriophage preparations comprising purification using affinity chromatography|
The proposed method facilitates the single-stage and at the same time effective purification of phage preparations for therapeutic uses, and facilitates the maintenance of bacteriophage antibacterial activity both in the case of displacement of the bacteriophage from the resin and its proteolytic release. The protein modification of the phage capsid with appropriate binding motifs makes it possible to purify therapeutically bacteriophage strains using affinity chromatography.
|Method of detecting ethylated thymidine dna adducts|
A method of analyzing ethylated thymidine dna adducts is disclosed. The method comprises the steps of: providing leukocyte dna; adding at least one isotope-labeled internal standard and a plurality of enzymes to the leukocyte dna, and hydrolyzing the leukocyte dna into a plurality of nucleosides; using a solid-phase extraction column to extract the plurality of nucleosides; and using a stable isotope dilution nanoflow liquid chromatography-nanospray ionization tandem mass spectrometry to detect and quantify at least one ethylated thymidine dna adduct in the plurality of extracted nucleosides..
|Integrated electrospray ionization emitter and detection cell for parallel measurements by fluorescence and mass spectrometry|
An integrated mass spectrometer electrospray emitter and fluorescence detector allows improved volumetric measurements of separate components from a liquid chromatography column by improving correlation between the readings of these instruments and reducing dead volume and sample size requirements.. .
|Single unit ion exchange chromatography antibody purification|
The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate and polishing step comprises in either order in-line anion exchange chromatography (aex) chromatography and cation exchange chromatography (cex) chromatography steps in flow-through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a cation exchange chromatography part in either order, which are serially connected, wherein the unit comprises an inlet at the upstream end of the first ion exchange chromatography part and an outlet at the downstream end of the second ion exchange chromatography part and wherein the unit also comprises an inlet between the first ion exchange chromatography part and the second ion exchange chromatography part..
|Aliphatic amino acid biosynthesis inhibitors and a method of synthesizing the same|
The embodiments herein provide a composition and a method of synthesizing a composition comprising an aliphatic amino acid biosynthesis inhibitor having an antifungal activity. The composition comprises 2-oxo-2h-chromen-7-yl propiolate, diethyl-hex-2-en-4-yne-dioate and dinonyl-hex-2-en-4-yne-dioate.
|Purification of vaccinia viruses using hydrophobic interaction chromatography|
The present invention relates to methods for purification of vaccinia viruses (vv) and/ or vaccinia virus (vv) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a virus preparation in a sterilized way with high efficiency and desirable yield in terms of purity, biological activity and stability, aspects advantageous for industrial production..
|Pressure-sensitive adhesive composition for use on an optical film, pressure-sensitive adhesive layer, pressure-sensitive adhesive layer-carrying optical film, and image display device|
A pressure-sensitive adhesive composition for use on an optical film, includes a (meth)acryl-based polymer obtained by copolymerization of 30 to 98.9% by weight of an alkyl(meth)acrylate, 1 to 50% by weight of an aromatic ring-containing polymerizable monomer, 0.1 to 20% by weight of a hydroxyl group-containing monomer, and 0 to 4% by weight of a carboxyl group-containing monomer, and a solvent. The (meth)acryl-based polymer has a weight average molecular weight of 300,000 to 1,200,000 as measured by gel permeation chromatography.
|Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography|
Disclosed herein are methods for the isolation and purification of anti-il-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., protein a affinity chromatography), ion exchange chromatography, and hydrophobic chromatography.
|High-pressure control valve for high-performance liquid chromatography|
A high-pressure switching valve includes a stator and a rotor. The stator includes a plurality of ports where each port is connected at one end to a port connection and having at another end a predetermined port opening cross section at a stator end face of the stator.
|Quantification of impurities for release testing of peptide products|
The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main product. The method particularly involves the use of high resolution mass spectrometry (ms) detection with or without high performance liquid chromatography (hplc).
|Chromatography equipment characterization|
Herein is reported a method for determining whether a re-usable chromatography column packing, which is used at least for the second time in a purification step of a purification of a polypeptide, has reduced separation efficacy in said purification step of said purification of said polypeptide, comprising the following steps: a) identifying and determining the experimental data of an inert change of at least one physicochemical parameter of a mobile phase passing through said re-usable chromatography column packing, b) determining the parameters of a function of formula i by fitting the experimental data of the inert change of the physicochemical parameter of the at least second use, c) determining the difference between the experimental data of the inert change of the physicochemical parameter of the at least second use and the function of formula i with the parameters determined in step b), d) calculating the difference between the maximum value and the minimum value of the difference determined in step c) and normalizing said difference, e) determining reduced separation efficacy of said re-usable chromatography column packing when the absolute value of the difference calculated in step d) is more than 0.1.. .
The present invention is directed to a continuous affinity chromatography method and to an apparatus to be used in such method. The method allows the use of high operational velocity while maintaining high binding capacities..
|High purity lipopetides|
The invention discloses highly purified daptomycin and to pharmaceutical compositions comprising this compound. The invention discloses a method of purifying daptomycin comprising the sequential steps of anion exchange chromatography, hydrophobic interaction chromatography and anion exchange chromatography.
|Quantification and characterization of allergens|
Embodiments of the invention include methods of determining the allergen content of a composition. Embodiments of the invention may include providing a composition comprising an allergen; at least partially purifying the allergen from the composition to form an extract; and determining the amount of allergen in the extract using liquid chromatography with ultraviolet and mass spectrometric detection..
|Adhesive composition for optical films, adhesive layer for optical films, pressure-sensitive adhesive layer-carrying optical film, and image display device|
A pressure-sensitive adhesive composition for use on an optical film, includes a (meth)acryl-based polymer obtained by copolymerization of 30 to 98.9% by weight of an alkyl(meth)acrylate, 1 to 50% by weight of an aromatic ring-containing polymerizable monomer, and 0.1 to 20% by weight of a hydroxyl group-containing monomer, and a solvent. The (meth)acryl-based polymer is free of any carboxyl group-containing monomer unit and has a weight average molecular weight of 300,000 to 1,200,000 as measured by gel permeation chromatography.
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Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine
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