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Chromatography patents



      

This page is updated frequently with new Chromatography-related patent applications.




Date/App# patent app List of recent Chromatography-related patents
05/26/16
20160146771 
 Methods for the detection of spoilage of oils patent thumbnailnew patent Methods for the detection of spoilage of oils
Methods for the detection of spoilage of oils containing unsaturated fatty acids is disclosed. Specific methods include the determination of p-anisidine in oils containing unsaturated fatty acids using high performance liquid chromatography after p-an-isidine is added to the oil containing unsaturated fatty acids, and allowed to react with oxidation products..
Nordic Naturals, Inc.


05/26/16
20160146753 
 Method of detecting and quantifying perchlorate contamination patent thumbnailnew patent Method of detecting and quantifying perchlorate contamination
A method of detecting and quantifying perchlorate contamination in samples, especially samples with complex background matrices such as food and produce with trace levels of perchlorate. A simple microwave assisted-electromembrane extraction provides simultaneous reduced extraction time, sample clean-up, high recovery and enrichment of perchlorate ions for detection and quantification by ion chromatography.
King Fahd University Of Petroleum And Minerals


05/26/16
20160145184 
 Process for equilibrium-limited reactions patent thumbnailnew patent Process for equilibrium-limited reactions
A process for conducting equilibrium-limited chemical reactions that produce water as a reaction product. Specifically, a process that uses a reactive chromatography unit (rcu) to improve the efficiency of equilibrium-limited reactions, such as a process for reacting glycol ether (ge) and carboxylic acid (ca) to form water and glycol ether ester (gee).
Dow Global Technologies Llc


05/26/16
20160145167 
 Reactive chromatography process for equilibrium-limited reactions patent thumbnailnew patent Reactive chromatography process for equilibrium-limited reactions
The present disclosure provides for a process for an equilibrium limited reaction using reactive chromatography unit (rcu) in which a first organic donor reactant (fodr) and a second organic acceptor reactant (soar) react to form a product mixture of a first acceptor product (fap) and a second donor co-product (sdcp). The equilibrium-limited reaction does not produce water.
Dow Global Technologies, Llc


05/26/16
20160144358 
 Dynamic lab on a chip based point-of-care device for analysis of pluripotent stem cells, tumor cells, drug metabolites, immunological response, glucose monitoring, hospital based infectious diseases, and drone delivery point-of-care systems patent thumbnailnew patent Dynamic lab on a chip based point-of-care device for analysis of pluripotent stem cells, tumor cells, drug metabolites, immunological response, glucose monitoring, hospital based infectious diseases, and drone delivery point-of-care systems
The invention provides for a novel dynamically configurable point-of-care device for clinical diagnostics and research for analysis of activity associated with pluripotent stem cells, tumor cells, drug metabolites, immunological response, glucose monitoring, cardiovascular diseases, liver cell therapy, cell-cell signaling, epidemic outbreaks, hospital based infectious diseases, pathogens, germ cells, pharmacological compounds, oxidation reduction, microscopy, tomography, flow cytometry, clinical lab testing, and for providing immunoassays, elisa, electrophoresis, pcr, chromatography, and other laboratory functions. The device comprises a biochemical processing module further comprising a processor and at least one controller, receiving microfluidic elements, sensors, software scripts, an electrically operated interface, flow ports, a user interface, memory, and a communications link, configurable based on analysis of patient data.

05/26/16
20160144293 
 Chromatography column distribution system patent thumbnailnew patent Chromatography column distribution system
A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs.
Ge Healthcare Bio-sciences Ab


05/26/16
20160143888 
 Formulations of bendamustine patent thumbnailnew patent Formulations of bendamustine
Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable fluid which can include in some embodiments peg, pg or mixtures thereof and an antioxidant or chloride ion source.
Eagle Pharmaceuticals, Inc.


05/26/16
20160143887 
 Formulations of bendamustine patent thumbnailnew patent Formulations of bendamustine
Long term storage stable bendamustine-containing compositions are disclosed. The compositions can include bendamustine or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable fluid which can include in some embodiments peg, pg or mixtures thereof and an antioxidant or chloride ion source.
Eagle Pharmaceuticals, Inc.


05/19/16
20160141164 
 Method for time-alignment of chromatography-mass spectrometry data sets patent thumbnailMethod for time-alignment of chromatography-mass spectrometry data sets
A method is disclosed for adjusting the time scale of chromatography-mass spectrometry data sets, wherein a time scale of a first data set is used as a reference time scale and wherein a time scale of at least one second data set is adapted to the reference time scale comprising the. The steps of the method include identifying feature groups in the first data set by evaluating intensities of consecutive points of the first data set; identifying feature groups in the second data set by evaluating intensities of consecutive points of the second data set; matching feature groups of the first data set to feature groups of the second data set, and determining a corrected time scale for the second data set based on time differences between feature groups in the first data set and matching feature groups in the second data set..
Thermo Fisher Scientific (bremen) Gmbh


05/19/16
20160139125 
 Immunochromatography device for detecting rsv patent thumbnailImmunochromatography device for detecting rsv
The present invention provides an easy-to-use and higher-sensitivity immunochromatography device for an rsv, the device using an antibody that binds specifically to f protein of the rsv in a determination region of a chromatography medium, a test kit by an immunochromatography method, and a method for detecting an rsv using these device and kit. The present invention relates to an immunochromatography device in which not only an antibody that binds specifically to f protein of an rsv but also an antibody that binds specifically to n protein of the rsv is solid-phased in a determination region of a chromatography medium.
Tanaka Kikinzoku Kogyo K.k.


05/19/16
20160139095 

Systems and methods of compensation for chromatography column volume variations


Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column.
Waters Technologies Corporation


05/19/16
20160139092 

Carbon dioxide liquid phase forming using high volume head displacement


Systems and methods for pumping carbon dioxide in a chromatography system include an actuator that receives and compresses carbon dioxide at or above room temperature at a given pressure to put the carbon dioxide in or near supercritical form. This actuator can be a pre-pump disposed on the intake side of a pumping system.
Waters Technologies Corporation


05/19/16
20160139091 

Traps for use with chromatography systems


Certain configurations are provided herein of a trap that can be used with chromatography systems. In certain instances, the trap may be designed to remove substantially all oil in a sample comprising the oil and an analyte of interest.
Perkinelmer Health Sciences, Inc.


05/19/16
20160139014 

Nanometer size chemical modified materials and uses


Ligand compositions and stationary phases comprising polyhedral oligomeric silsesquioxane moieties are incorporated in to chromatographic stationary phases, and these phases are incorporated into chromatography devices, such as columns. The compositions and devices are of use to separate molecular mixtures..
Dionex Corporation


05/19/16
20160138097 

Method for detecting methylated dna


Provided is a rapid and simple method of detecting methylated dna. The method of detecting methylated dna includes the following steps of: (1) treating sample dna with a hydrogen sulfite; (2) amplifying the sample dna treated with the hydrogen sulfite by pcr; and (3) subjecting the resultant pcr amplification product to ion-exchange chromatography..
Mie University


05/19/16
20160137644 

Method for producing tricyclic heterocyclic compound


It is an object of the present invention to provide a method for producing a high-purity tricyclic heterocyclic compound represented by formula (i), which is useful as a production intermediate for a pharmaceutical agent, wherein the method is an efficient production method with short steps and with a high yield, which does not use, as raw materials, expensive bromopyruvate and highly harmful copper chromite, and does not need silica gel column chromatography that generates, as by-products, large quantities of waste. The present invention relates to production of compound (i) by the following method..
Daiichi Sankyo Company, Limited


05/19/16
20160137604 

Purification of intermediates used in the preparation of heterobifunctional linkers


The present invention is directed to a method of separating a monocarboxylic represented by the following stmctural formula: (i) from a dicarboxylic acid represented by the following structural fonnula: (ii) using silica chromatography.. .
Immunogen, Inc.


05/19/16
20160137530 

Ion exchange based volatile component removal device for ion chromatography


A method, device, and system for removing a volatile component from a liquid solution for a chromatographic separation are described. The method includes the flowing of a liquid solution through a first chamber of the device.
Dionex Corporation


05/19/16
20160136544 

Methodology for scaling methods between supercritical fluid chromatography systems


A methodology scales supercritical fluid chromatography (sfc) and/or carbon dioxide based chromatography methods between different system and/or column configurations. The methodology includes measuring an average mobile phase density during a first separation utilizing co2 as a mo bile phase component and substantially duplicating the average density profile for a second separation.
Waters Technologies Corporation


05/19/16
20160136542 

Superficially porous particles with precisely controlled particle density, and methods of preparation and use thereof


The invention provides superficially porous metal oxide particles with precisely controlled particle density and to methods for their preparation and use, as well as to separation devices (e.g., high pressure liquid chromatography) having superficially porous particles.. .
Agilent Technologies, Inc.


05/12/16
20160131644 

Method for detection of protein comprising histidine-tag using immunochromatography


The present invention relates to a method for the detection of a protein including a histidine-tag using immunochromatography. The detection method of the present invention uses immunochromatography using the polymer particle fixed with the histidine-tag, wherein a histidine-tag specific antibody alone is used to detect a histidine-tag conjugated protein (recombinant protein) quickly without using a target protein specific antibody.
Daegu Gyeongbuk Institute Of Science And Technology


05/12/16
20160131620 

Enhanced sensitivity of detection in electrospray ionization mass spectrometry using a post-column modifier and a microfluidic device


A microfluidic liquid chromatography-electrospray ionization (lc-esi) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent.
Waters Technologies Corporation


05/12/16
20160131617 

Liquid flow rate measurement device


Apparatus and method measure the flow rate of fluid for use in calibrating fraction collection in a chromatography system. An injector inserts a detectable substance into a flow of fluid.
Waters Technologies Corporation


05/12/16
20160131584 

Compositional analysis of a gas or gas stream in a chemical reactor and preparing chlorosilanes in a fluidized bed reactor


The composition of a gas or gas stream containing alcl3 in a chemical reactor is measured by removing alcl3 from the gas and analyzing the gas by gas chromatography or spectroscopy. Chlorosilanes may be prepared in a fluidized bed reactor having a reactor height h0, in which supplied hcl reacts with silicon, wherein a temperature profile in the fluidized bed reactor is greater than s1(h/h0)=(a1−b1)*(1/(1+exp(−c1((h/h0)−d1))))+b1 and less than s2(h/h0)=(a2−b2)*(1/(1+exp(−c2((h/h0)−d2))))+b2, where a1=100° c., a2=300° c., b1=300° c., b2=400° c., c1=50, c2=20, d1=0.2, and d2=0.8..
Wacker Chemie Ag


05/12/16
20160130339 

Isolation and purification of anti-il-13 antibodies using protein a affinity chromatography


Disclosed herein are methods for the isolation and purification of anti-il-13 antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography (e.g., protein a affinity chromatography), ion exchange chromatography, and hydrophobic chromatography.
Abbvie Inc.


05/12/16
20160129420 

Preparation chromatography medium


A method for preparing a chromatography medium having the properties of high virus adsorption and high fluidity, and a method for producing a virus vaccine using the chromatography medium are provided. The chromatography medium is obtained by forming a sulfated polysaccharide bound with porous particles having an exclusion limit molecular weight of 6000 da or less when pure water is used as mobile phase and standard polyethylene glycol is used and an average particle size in the range of 30-200 μm..
Jnc Corporation


05/05/16
20160126461 

Organic light emitting device


An oled comprising a hole-transporting layer and light-emitting layer wherein the hole-transporting layer comprises a hole-transporting polymer wherein no more than 5% of the polystyrene equivalent polymer weight measured by gel permeation chromatography consists of chains with weight of less than 50,000.. .
Cambridge Display Technology Limited


05/05/16
20160126075 

Mass spectrometry measuring vitamin b6 in body fluids


Provided are methods of detecting the presence or amount of the active form of vitamin b6, pyridoxal 5′-phosphate, in a body fluid sample using tandem mass spectrometry coupled with liquid chromatography.. .
Quest Diagnostics Investments Incorporated


05/05/16
20160123936 

Versatile ambient ionization-based interface for lc/ms


An apparatus (10) for coupling liquid chromatography with mass spectrometry and for splitting and analyzing a liquid sample includes a fluid conduit (16), which defines a flow passage (18) and is configured to supply the liquid sample. The fluid conduit (16) has an outer surface and a micro-hole (30) through the outer surface into the flow passage (18).
Ohio University


05/05/16
20160122385 

Methods of increasing protein purity using protein a based chromatography


The present invention provides methods for increasing purity of an fc-containing protein by removing protein aggregates during the protein a chromatography step used during the purification of the fc-containing protein.. .
Emd Millipore Corporation


05/05/16
20160122384 

Method for purifying antibody


The present invention relates to a method of purifying an antibody with high purity and high quality by removing impurities by sequential use of a cation-exchange column, a culture supernatant multilayer filter and an anion-exchange column without using a protein-a column that is an affinity chromatography column which is generally used for antibody purification.. .
Prestige Biopharma Pte. Ltd.


05/05/16
20160122191 

Particle of modified silica


The present invention relates to a particle of modified silica which comprises a particle of silica which is covalently linked to at least one halohydrin moiety. Furthermore, the present invention relates to a method of preparing the particle of modified silica, a particle of modified silica obtained by such method, use of the particle of modified silica as a stationary phase for chromatography, as well as a separation column for chromatography comprising the particle of modified silica..
Akzo Nobel Chemicals International B.v.


04/28/16
20160118605 

Light-emitting element, light-emitting device, electronic device, and lighting device


A long-life light-emitting element is provided by reducing a specific kind of impurity in the light-emitting element, particularly an impurity originating in an iridium complex. The light-emitting element includes an iridium complex.
Semiconductor Energy Laboratory Co., Ltd.


04/28/16
20160116447 

Gas chromatography (gc) column heater


An apparatus includes a first column heating apparatus, which includes: a first substrate; a second substrate including silicon; and a first heating element disposed between the first substrate and the second substrate. The apparatus also includes a second column heating apparatus, which includes: a third substrate; a fourth substrate including silicon; and a second heating element disposed between the third substrate and the fourth substrate..
Agilent Technologies, Inc.


04/28/16
20160116088 

Face-sealing fluidic connection system


A tubing or fitting assembly has an inner tube layer, an outer tube layer, a sleeve, a tip portion, and can have a nut. Each of the nut, sleeve, inner and outer tubing layers, and tip portion have a passageway therethrough, with at least the passageways in the sleeve, tip portion, outer tube layer, and nut adapted to allow the inner tube layer to pass therethrough or extend over the inner layer.
Idex Health & Science Llc


04/28/16
20160115560 

Methods of separating components using multi-scale simulated moving bed chromatography


Described is a method of separating a product from a feed stream. The method comprises introducing a feed stream comprising a product and at least one other component to a simulated moving bed system.
Amalgamated Research Llc


04/28/16
20160115195 

Purification process for monoclonal antibodies


The present invention provides an improved method for the purification of monoclonal antibody from cell culture. Process of purification of the desired monoclonal antibody comprises affinity, hydrophobic interaction and optionally ion exchange column chromatography.
Cadila Healthcare Limited


04/28/16
20160115193 

Novel purification of antibodies using hydrophobic interaction chromatography


Disclosed herein are compositions and methods for purifying antibody products from a sample matrix. In particular, the present invention relates to compositions and methods for purifying antibody products employing hydrophobic interaction chromatography media.
Abbvie, Inc.


04/21/16
20160109473 

Web-based interactive process facilities and systems management


Web-based interactive process facilities and systems management apparatus and methods are described, which have general applicability to industrial facilities and equipment utilized to carry out unit or sequential operations in the specific processing application. The apparatus and methods of the present disclosure have particular applicability to the management and operation of commercial high pressure liquid chromatography installations, and enable a substantial simplification of chromatography instruments to be employed in networked arrangements..

04/21/16
20160108119 

Protein purification


The present invention relates to a process for the purification of an antibody fragment from a periplasmic cell extract comprising a first cation exchange chromatography step and a second anion exchange chromatography step.. .

04/21/16
20160108084 

Purification of recombinantly produced polypeptides


Described herein is a method for separating a recombinantly produced polypeptide from host cell protein. The method includes a step of loading a clarified cell culture supernatant that includes the recombinantly produced polypeptide and the hcp onto a protein a chromatography column and washing the protein a chromatography column with a wash buffer comprising a fatty acid having a chain length of at least about 6 carbon atoms, or a fatty acid salt thereof to remove hcp and then recovering the recombinantly produced polypeptide..

04/21/16
20160108075 

Process for producing a particulate composition comprising crystalline trehalose dihydrate


A process for enabling the production of a particulate composition containing crystalline trehalose dihydrate is provided. Including allowing an α-glycosyltrehalose-forming enzyme to act on liquefied starch derived from a microorganism of the genus arthrobacter and a trehalose-releasing enzyme derived from a microorganism of the genus arthrobacter along with a starch debranching enzyme and a cyclomaltodextrin glucanotransferase; allowing glucoamylase to act on the resulting mixture to obtain a saccharide solution containing α,α-trehalose; precipitating crystalline α,α-trehalose dihydrate from the above saccharide solution; collecting the precipitated crystalline α,α-trehalose dihydrate by a centrifuge; and ageing and drying the collected crystals.

04/14/16
20160103596 

Chromatography configuration interface


Systems and methods that facilitate the setup and visualization of a configurable process, for example a chromatography experiment to be conducted using a configurable chromatography system. A user interface displays category regions representing sections of a process, and displays a plurality of selectable items representing components appropriate for placement in the category regions.

04/14/16
20160103104 

Integrated fluidic system for gas chromatography


A method is presented for fabricating a fluidic system for a gas chromatograph. The method includes: microfabricating a portion of a fluidic system of a gas chromatograph on a substrate using a first mask; microfabricating a portion of the fluidic system of the gas chromatograph using a second mask; and microfabricating a portion of the fluidic system of the gas chromatograph using a third mask, such that the first mask, the second mask and the third mask are different from each other and the microfabricating of the fluidic system of the gas chromatograph is completed using only the first, second and third masks.

04/14/16
20160103103 

Column device for liquid chromatography and liquid chromatography apparatus


A cylindrical column body (101) holds a filler. A pair of end caps (105, 106) covers both ends of the column body (101) and has a flow hole for a carrier liquid (111, 112) arranged in the center thereof.

04/14/16
20160103045 

All-in-one sample preparation device and method


Sample preparation device that allows for a complete bind, wash, elute, buffer-exchange and concentration process to be carried out without sample transfer between multiple devices. The device includes a reservoir, a column for holding chromatography media, a holder region for holding a filtration device, and an outlet.

04/14/16
20160101181 

Process for reducing subvisible particles in a pharmaceutical formulation


The present disclosure provides a stable protein composition containing a surfactant and having less than 400 subvisible particles of 10 microns or greater diameter per container, or less than 10,000 subvisible particles of 2 microns or greater per container. A method of manufacturing such a stable protein composition is disclosed, which includes a unit of operation that removes or decreases an esterase activity that degrades the surfactant.

04/07/16
20160097073 


An assembly capable of capturing and purifying expressed biological products during or at the end of a bioreaction cycle is disclosed wherein a binding resin is kept separated from the contents of the bioreactor allowing capturing, harvesting and purification of biological products in a bioreactor; the invention additionally provides means of removing undesirable metabolic products as well as provides for efficient loading of chromatography columns.. .
Therapeutic Proteins International, Llc


04/07/16
20160096808 

Methods of resolving racemic mixture to obtain (-)-huperzine a


A method of resolving a racemic mixture of (±)-huperzine a to (−)-huperzine a includes: separating the (−)-huperzine a from the racemic mixture of (±)-huperzine a by chiral high performance liquid chromatography (hplc), the chiral hplc being performed utilizing a mobile phase including a solution including an alcohol and one selected from dichloromethane, trichloromethane, and a mixture thereof, and the chiral hplc being performed utilizing a chiral stationary phase including a polysaccharide derivative.. .
Amphastar Pharmaceuticals Inc.


03/31/16
20160091468 

Method for measuring relative content of gram-negative bacteria in active sludge


A method for measuring a relative content of gram-negative bacteria in an active sludge, the method including: 1) breaking zoogloeas in the active sludge; 2) isolating 2-keto-3-deoxyoctonic acid (kdo) from free bacteria and cell debris; 3) performing fluorescence labeling on the isolated kdo to obtain a fluorescent derivative; and 4) isolating the fluorescent derivative by high performance liquid chromatography (hplc) and conducting quantitative measurement by fluorescence to obtain the relative content of the gram-negative bacteria in the active sludge.. .
Nanjing University


03/31/16
20160091467 

Prediction of fuel properties


A system is described that includes a known fuels database of data from gas chromatography-mass spectrometry analyses of a library of fuels with known fuel properties for a multiple known fuel samples. Gas chromatography-mass spectrometry equipment can acquire gas chromatography-mass spectrometry data for an unknown fuel sample.
The Government Of The United States Of America, As Represented By The Secretary Of The Navy


03/24/16
20160084808 

Method and device for determining a composition of a gas sample processed by means of gas chromatography


A method for determining a composition of a gas sample comprising the following steps: running the sample through a processing chain comprising a gas chromatography column and a gas detector arranged at the outlet of the gas chromatography column; obtaining, at the output of the detector, a representative electrical signal of the composition; determining the gas composition by processing this electrical signal. The determination of the composition of the sample is performed on the basis of a combination of a direct probabilistic model of the chromatography column, this model comprising at least one law of probability defining, for at least one gas species liable to be found in the sample, a probability at each moment that a molecule of this gas species is discharged from the chromatography column, and an impulse response model of the detector.
Commissariat A L'energie Atomique Et Aux Energies Alternatives


03/24/16
20160084807 

Automated calibrating a chromatography system and analysis of a sample


An automated method of calibrating a chromatography system and analyzing a sample is described. The method includes forming diluted standard solutions that are injected into a chromatography column.
Dionex Corporation


03/24/16
20160084806 

Micro-machined frit and flow distribution devices for liquid chromatography


A micro-machined frit is provided for use in a chromatography column, having a substrate with a thickness, and holes extending through the thickness and providing fluid communication through the substrate. A micro-machined flow distributor is provided for use in a chromatography column having a substrate, holes extending through the substrate, and channels in fluid communication with the holes.
Agilent Technologies, Inc.


03/24/16
20160084804 

Cation exchanger for liquid chromatography, process for producing same, and use thereof


A cation exchanger for liquid chromatography, comprising non-porous particles and, immobilized to the surface thereof, a polyacrylic acid into which a dicarboxylic acid compound having an amino group is introduced by an amide bond.. .

03/24/16
20160084779 

Nuclear magnetic resonance implemented synthetic indole and indazole cannabinoid detection, identification, and quantification


The present invention provides a method for detecting synthetic indole and indazole cannabinoids in a sample known or suspected to contain a synthetic indole or indazole cannabinoid. A deuterated solvent is added to the solid sample, creating a suspension.
Hofstra University


03/24/16
20160083630 

Composition for pressure-sensitive adhesive and pressure-sensitive adhesive sheet


A composition for a pressure-sensitive adhesive, includes (a) a (meth)acrylic ester polymer having a trithiocarbonate structure, having hydroxyl groups at both ends of a molecule and having a weight-average molecular weight (mw), as measured by gel permeation chromatography, of 50,000 to 300,000, and (b) an isocyanate compound having an average number of isocyanate groups in one molecule being more than 2.. .
Soken Chemical & Engineering Co., Ltd.


03/24/16
20160083454 

Continuous multistep process for purifying antibodies


The invention provides a three-step chromatography process for small and large-scale purification of proteins, specifically monoclonal antibodies, using only four buffer solutions made from a mother solution.. .
Sanofi


03/24/16
20160083453 

Separation of recombinant polyclonal antibody multimers with minimal separation of monomers


The invention provides a method for removing multimers from a preparation of recombinant polyclonal antibodies (rpabs) while maintaining the ratio of monomers within a narrow range. The invention provides a method of separating recombinant polyclonal antibody multimers with minimal separation of monomers comprising subjecting a mixture comprising a plurality of monoclonal antibodies to at least one separation process selected from the group consisting of multi-modal chromatography, apatite chromatography, and hydrophobic interaction chromatography thereby producing an antibody monomer preparation that is substantially free of multimers..
Medlmmune, Llc


03/24/16
20160083452 

Isolation and purification of antibodies using protein a affinity chromatography


Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably protein a affinity, ion exchange chromatography, and hydrophobic chromatography.
Abbvie Inc.


03/24/16
20160083419 

Method for purifying antibody protein


A method for purifying a biologically active substance from a solution mixture containing impurities and the biologically active substance, in which an ion exchange chromatography carrier comprising a matrix and a copolymer containing at least n-isopropylacrylamide as a monomer unit and immobilized to a surface of the matrix is used, and the solution mixture is allowed to flow through a container storing the carrier at a uniform temperature, thereby recovering the biologically active substance.. .
Asahi Kasei Medical Co., Ltd.


03/24/16
20160083356 

Functionalized 4- and 5-vinyl substituted regioisomers of 1, 2, 3-triazoles via 1, 3- dipolar cycloaddition and polymers thereof


The present invention provides novel functionalized mixtures 4- and 5-vinyl substituted regioisomers of 1,2,3-triazoles via 1,3-dipolar cycloaddition. Functionalized alkyne moieties with a terminal alcoholic functionality are reacted with functionalized organic moieties with a terminal leaving group and an azide to provide an alcoholic functionalized mixture of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties.
Isp Investments Inc.


03/24/16
20160083329 

Preparation 1-palmitoyl-3-acetylglycerol, and preparation 1-palmitoyl-2-linoleoyl-3-acetylglycerol using same


Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in high purity and high yield without a purification process using a column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in high purity and high yield using the same as a key intermediate. The method for preparing 1-palmitoyl-3-acetyl glycerol comprises the steps of: forming a reaction mixture including 1-palmitoyl-3-acetyl glycerol of the formula 1 in the specification by reacting 1-palmitoylglycerol of the formula 2 in the specification and an acetylating agent; and separating the optically active 1-palmitoyl-3-acetylglycerol by crystallizing the reaction mixture in a saturated hydrocarbon solvent having 5 to 7 carbon atoms..
Enzychem Lifesciences Corporation


03/17/16
20160077068 

Thin-layer chromatography plate, producing such a plate, and performing a thin-layer chromatography separation


The present invention relates to a thin-layer chromatography plate at least consisting of a support and a sorbent layer, where the sorbent layer comprises at least one siloxane oligomer, to a process for the production thereof, and to a method for carrying out a thin-layer chromatographic separation using said thin-layer chromatography plate.. .
Merck Patent Gmbh


03/17/16
20160077067 

Multi-measurement flow cell assembly for liquid chromatography


A detector for detecting constituents of a liquid for use in liquid chromatography is disclosed. The detector includes a first optical flow cell body and a second optical flow cell body, each having a channel therethrough that allows passage of a liquid from an inlet port to an outlet port.
Practichem Llc


03/17/16
20160077064 

Gas chromatography (gc) column heater


A gas chromatography (gc) column heating apparatus is described. The gc column heating apparatus includes a first substrate; a heating element disposed over the first substrate; and a second substrate.
Agilent Technologies, Inc.


03/17/16
20160077063 

Gas chromatography (gc) column heater


An apparatus for heating a gc column is described. The apparatus includes first and second temperature sensors.
Agilent Technologies, Inc.


03/17/16
20160077062 

Sample dispenser for an analytical device


A sample dispenser for an analysis device, in particular for an analysis device working according to the principle of liquid chromatography, in particular high pressure liquid chromatography, or gas chromatography, comprising a sample intake for receiving a sample to be analyzed, an inlet through which an eluent can be supplied, an outlet, and an injection valve arrangement, which can be switched at least from an intake position to an injection position, wherein, at least in the intake position and in the injection position, the inlet is in fluid connection with the outlet to deliver the eluent—if applicable, having the sample added thereto—at least partly to the outlet, wherein, in the intake position, the sample intake is separated from the eluent in a fluid-tight manner, and wherein, in the injection position, the sample in the sample intake can combine with the eluent, wherein the sample dispenser is configured as a disposable component.. .
Hamilton Bonaduz Ag


03/17/16
20160075678 

Facile and selective perfluoro-and polyfluoroarylation of meldrums acid


This disclosure relates generally to the facile and selective mono-perfluoro and polyfluoroarylation of meldrum's acid to generate a versatile synthon for highly fluorinated alpha-phenyl acetic acid derivatives which provide straightforward access to fluorinated building blocks. The reaction takes place quickly and all products were isolated without the need for chromatography.
The Board Of Regents For Oklahoma State University


03/17/16
20160075624 

Process for preparing and separating monodisperse polyethylene glycol


A process for preparing and separating a monodisperse polyethylene glycol, including: dissolving a starting material of polyethylene glycol into an organic solvent for reaction with a compound represented by general formula i under catalytic action of an alkaline substance, to prepare a mixture of derivatives of polyethylene glycol having different polarities; separating the mixture of derivatives of polyethylene glycol by means of silica gel column chromatography, to obtain a monodisperse derivative of polyethylene glycol; and hydrolyzing the derivative of polyethylene glycol to obtain a monodisperse polyethylene glycol. The starting material is industrially prepared polyethylene glycol with a wide source and low cost, which provides a guarantee for popularization and application of a monodisperse polyethylene glycol product..
Opegchem Company, Inc.


03/17/16
20160074775 

Continuous chromatography method and system


Continuous chromatography methods and systems are disclosed, wherein a tangential flow filtration device used in association with at least a first chromatography device and a second chromatography device, concentrate a product of interest, which improves sorbent utilization.. .
Pall Corporation


03/17/16
20160074774 

Chromatography method and system


chromatography methods and systems are disclosed, wherein a tangential flow filtration device is used to concentrate a product of interest, which improves sorbent utilization.. .
Pall Corporation


03/10/16
20160069845 

Thermally modulated variable restrictor for normalization of dynamic split ratios


A chromatography system includes a separation column that separates a sample carried by a compressible mobile phase flow into analytes and a splitter in fluidic communication with the separation column to receive and divide the compressible mobile phase flow into first and second mobile phase streams in accordance with a split ratio. A thermally modulated variable restrictor is coupled between the splitter and a detector.
Water Technologies Corporation


03/10/16
20160069844 

Controllable injector sample dilution for a liquid chromatography system


Described are a method and a system for injecting a sample into a flow of a liquid chromatography system. The method includes combining a flow of a sample and a flow of a mobile phase to create a diluted sample in the system flow.
Waters Technologies Corporation


03/10/16
20160067634 

Microstructure separation filters


Microstructure separation filters are provided herein, as well as chromatography and other separation devices. An exemplary filter device includes a microstructure filter has a plurality of layers of alternating sacrificial and/or structural material which have been etched to create inlet channels and outlet channels.
Imagine Tf, Llc


03/10/16
20160067325 

Purification of polysaccharide protein conjugates


The invention describes a method of purifying polysaccharide protein conjugates using mixed mode chromatography. The method involves contacting a crude polysaccharide protein conjugate with a mixed mode resin comprising an inert porous shell and an activated core under conditions of low conductivity that allow binding of the contaminants and collecting the unbound polysaccharide protein conjugate in a flowthrough..
Shantha Biotechnics Private Limited


03/03/16
20160061804 

Simple the detection of sulfur compounds in crude oils and diesel


A liquid phase microextraction (lpme) method was developed for the determination of sulfur compounds in crude oils and its fractions (e.g diesel). Wide ranges of sulfur compounds including benzothiophene, dibenzothiophene and their derivatives were used as model compounds for extraction.
King Abdulaziz City For Science And Technology


03/03/16
20160061790 

Quantification of asphaltene inhibitors in crude oil using thermal analysis coupled with mass spectrometry


The present invention generally relates to a novel method for the characterization and quantification of involatile macromolecules in hydrocarbon samples of crude oil. More particularly, the method utilizes pyrolysis/gas chromatography/mass spectrometry (py/gc/ms, py/gc/ms/ms or py/gc/triple quad ms) to detect and quantify polymeric asphaltene inhibitors in crude oil..
Ecolab Usa Inc.


03/03/16
20160061789 

Plug unit and connection system for connecting capillary tubes, especially for high-performance liquid chromatography


A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit.
Dionex Softron Gmbh


03/03/16
20160061787 

Automated analysis systems


The disclosure relates to systems and methods for performing high performance liquid chromatography (hplc) on a liquid sample. The methods include automatically, using a computer, controlling a liquid sample including a plurality of components to flow through a first flow path in a system for hplc.
The General Hospital Corporation


03/03/16
20160061786 

Compositional analysis of high boiling point mixtures by comprehensive two-dimensional gas chromatography


The thermally modulated, two-dimensional gas chromatographic separation of a mixture of compounds with boiling points higher than 260° c. Uses a cold trap with a gas jet at ambient temperatures..
Exxonmobil Research And Engineering Company




Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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