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Chromatography patents

      

This page is updated frequently with new Chromatography-related patent applications.




 Systems, apparatus, and methods for analyzing and predicting cellular pathways patent thumbnailSystems, apparatus, and methods for analyzing and predicting cellular pathways
Integrative analysis of metabolites is essential to obtain a comprehensive view of dysregulated biological pathways leading to a disease. Despite the great potential of metabolites their system level analysis has been limited.

 Glycan sample preparation patent thumbnailGlycan sample preparation
The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation..
Beckman Coulter, Inc.


 Quantification of transthyretin and its isoforms patent thumbnailQuantification of transthyretin and its isoforms
The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry.
Alnylam Pharmaceuticals, Inc.


 High efficiency continuous countercurrent tangential chromatography patent thumbnailHigh efficiency continuous countercurrent tangential chromatography
A system, module and method for continuous or batch single-pass countercurrent tangential chromatography are disclosed for bind/elute and negative chromatography applications. The system includes binding, washing, elution (for bind/elute), regeneration, and equilibration single-pass modules.

 Wash solution comprising arginine for the affinity chromatography step in antibody purification patent thumbnailWash solution comprising arginine for the affinity chromatography step in antibody purification
The invention provides a washing method for affinity chromatography in which a wash solution comprising arginine, or an arginine derivative, and a nonbuffering salt, preferably at high ph, greater than 8.0, is effective in removing impurities, such as high molecular weight species and host cell proteins, while also increasing product concentration in the eluate and maintaining a high percent yield of recovered product.. .

 Preparation  high-purity 4'-galactosyl-lactose composition patent thumbnailPreparation high-purity 4'-galactosyl-lactose composition
A composition which has high 4′-gl purity and can be used as a reference standard for various analyses can be obtained by a more convenient method than one conventionally used. A method for preparing a high-purity 4′-gl composition includes the steps of: (a) subjecting a 4′-gl-containing galacto-oligosaccharide to activated carbon column chromatography, and performing stepwise elution with plural organic solvent aqueous solutions, wherein the organic solvent aqueous solutions are used such that the concentration of the organic solvent in the organic solvent aqueous solution is higher than the concentration of the organic solvent in the immediately preceding organic solvent aqueous solution with respect to a series of elutions; and (b) adding an organic solvent to the final fraction eluted in step (a), and crystallizing the 4′-gl..
Kabushiki Kaisha Yakult Honsha


 Solid-phase carrier, production  solid-phase carrier, carrier for affinity refining, production  filler for affinity chromatography, filler for affinity chromatography, chromatography column, and refining method patent thumbnailSolid-phase carrier, production solid-phase carrier, carrier for affinity refining, production filler for affinity chromatography, filler for affinity chromatography, chromatography column, and refining method
There are provided a solid-phase carrier and a carrier for affinity refining that exhibit high dynamic binding capacity when a ligand is immobilized, have excellent antifouling properties, and are unlikely to have non-specific adsorption of impurities. The solid-phase carrier has a functional group capable of fixing a ligand and is characterized by having a group having a sulfinyl group, a sulfide group, an oxy group or an imino group, and a hydroxyl group, a thiol group, an amino group, a carboxy group, a sulfate group, a phosphate group or an alkanoyl group..
Jsr Life Sciences Corporation


 Process for transfer of a method from a starting system to a target system in liquid chromatography patent thumbnailProcess for transfer of a method from a starting system to a target system in liquid chromatography
A process for transferring a method from a starting system to a target system in liquid chromatography, in particular in high performance liquid chromatography, is described. A first chromatogram of the method carried out on the starting system is available or determined.
Dionex Softron Gmbh


 Chromatography apparatus having diffusion-bonded and surface-modified components patent thumbnailChromatography apparatus having diffusion-bonded and surface-modified components
A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet.
Waters Technologies Corporation


 Plate for gas chromatograph with a capillary column, capillary device and gas chromatograph patent thumbnailPlate for gas chromatograph with a capillary column, capillary device and gas chromatograph
The present invention relates to gas chromatography with capillary column and more particularly to a plate for gas chromatograph with a capillary column, a capillary device and a gas chromatograph comprising such capillary device. At least one face of the plate is etched with a furrow forming a first part of the capillary column.
Total Sa


Gas chromatograph column connection device

A column connection device for use in gas chromatography is disclosed. The column connection device includes a housing with a piston, a piston spring retainer, and disk springs composed of an austenite nickel-chromium-based superalloy (e.g.
Perkinelmer Health Sciences, Inc.

Chromatography systems with mobile phase generators

Certain configurations of a gas chromatography system comprising an internal gas generator are described. In some instances, the gas chromatography system may comprise an internal hydrogen generator to provide hydrogen gas to a chromatography column for separation of analyte species.

Convectively controlled adiabatic column chamber for use in chromatographic systems

A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path.
Waters Technologies Corporation

Nucleic acid detection or quantification method using mask oligonucleotide, and device for same

Very simple, highly sensitive detection or quantification of target nucleic acids of interest has been achieved by: hybridizing mask oligonucleotides to regions in a single-stranded region of a nucleic acid to be assayed between which a region to be hybridized by an oligonucleotide probe is positioned, thereby opening the probe-hybridizing region and keeping the single-stranded region of the target nucleic acid stable, and then subjecting this nucleic acid having the single-stranded region to nucleic acid chromatography.. .
Fuso Pharmaceutical Industries, Ltd.

New process for the preparation of high purity prostaglandins

The subject of the invention is a process for the preparation of high purity prostaglandin acid of the general formula ii wherein the bonds marked with dotted lines represent single or double bonds wherein the double bonds may be cis- or trans oriented, y represents 0 or ch2, and r3 stands for a phenyl group which is optionally substituted with cf3, wherein the crude prostaglandin acid of the general formula ii is purified by normal phase silicagel chromatography.. .
Chinoin GyÓgyszer És VegyÉszeti TermÉkek GyÁra Zrt.

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Hoisting and holding system for chromatography column

A holding system for holding and hoisting a chromatography column of one or more chromatography columns is disclosed. The holding system includes an upright member and a plurality of holding members movably arranged along the upright member.
Ge Healthcare Bio-sciences Ab

Method and device for two-dimensional separation of ionic species

The invention relates to a method which realizes a two-dimensional separation of ionic species on the basis of the online coupling of ion chromatography (ic) and capillary electrophoresis (ce). A device for ic×ce coupling, its implementation in terms of two alternatives, the connection to a mass spectrometric detector, and corresponding application are described..
UniversitÄt Regensburg

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Novel purification process of gonadotropin

The present invention provides an improved method for the purification of desired gonadotropin from a crude mixture containing at least one contaminating protein. The process of purification of the desired gonadotropin according to the present invention comprises use of an affinity chromatography as the first column purification step, prior to use of any column chromatography steps for further purification.
Cadila Healthcare Limited

Ion-exchange composition comprising a complex of support particles, dispersant, and electrostatically bound layering particles

An ion-exchange composition suitable for use in ion exchange chromatography, comprising neutral vinyl polymer support particles irreversibly bound to a dispersant having ionizable sites which are un-ionized at a neutral ph and which are ionized under highly acidic or highly basic conditions, and fine layering particles functionalized with ion-exchanging sites on the surfaces thereof. A portion of the ionizable sites are ionized and bound electrostatically to a portion of the fine layering particles ion-exchanging sites, producing a support particle-dispersant-fine layering particle complex..
Dionex Corporation

Controlling hydrogen-deuterium exchange on a spectrum by spectrum basis

A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as hydrogen-deuterium exchange.
Micromass Uk Limited

Immunochromatographic analysis method

An object is to provide an immunochromatographic analysis method capable of shortening the developing time without decreasing the detection sensitivity, and also capable of reducing the return of the liquid of a developed component, and a method for detecting a detection target contained in an analyte using an immunochromatographic analysis device including an absorption part composed of glass fiber, wherein the analyte and a labeling substance are developed in a chromatography medium part as a mobile phase in the presence of a nonionic surfactant, and the detection target is detected in a detection part is provided.. .
Tanaka Kikinzoku Kogyo K.k.

Modular multiple-column chromatography cartridge

A method for liquid chromatography comprises steps of: mixing a sample comprising a plurality of chemical constituents with a first solvent; transferring the solvent and the plurality of constituents to a first chromatographic column housed in a cartridge; chromatographically separating a sub-group of the plurality of constituents from unwanted constituents using the first chromatographic column; transferring the sub-group of the plurality of constituents from the first chromatographic column to a second column housed in the cartridge, the transferring effected by the flow of a second solvent; chromatographically separating, from one another, individual constituents of the sub-group of the plurality of constituents using the second chromatographic column; and transferring the separated individual constituents to a detector.. .
Thermo Finnigan Llc

Methods for purifying adenovirus vectors

Methods of purifying an adenovirus from an impure preparation are provided. In some embodiments, a combination of mixed mode chromatography and anion exchange chromatography is used to purify the adenovirus..
Bio-rad Laboratories, Inc.

Affinity chromatography devices

The present invention is directed to affinity chromatography devices that separate a targeted protein or antibody from an aqueous mixture containing the targeted protein or antibody. The chromatography device may contain a stacked membrane assembly or a wound membrane assembly.
W. L. Gore & Associates, Inc.

Optimizing operating binding capacity for a multiple column chromatography process

Methods for optimizing operating binding capacity for a multiple column chromatography (mcc) process are disclosed.. .
Pall Corporation

Pressure-sensitive adhesive composition and acrylic pressure-sensitive adhesive composition

An object of the present invention is to provide an adhesive composition that is substantially odorless and has an extremely good color and excellent adhesive properties or tack at low temperatures of about 5° c. And in which deterioration over time caused by heat or light is suppressed.
Arakawa Chemical Industries, Ltd.

Method for purifying immunoglobulin

The present invention relates to a method for purifying an immunoglobulin, and more particularly, to a method for purifying an immunoglobulin, which comprises: dissolving immunoglobulin-containing plasma protein fraction i+ii+iii or fraction ii+iii; adding caprylate to the solution to cause precipitation; performing dialysis and concentration after removal of the precipitate; performing anion exchange resin and ceramic cation exchange resin purification processes to effectively remove a solvent and detergent added to inactivate viruses; and performing elution while maintaining salt concentration at a constant level to maintain the immunoglobulin polymer content at a low level. According to the method for preparing the intravenous immunoglobulin according to the present invention, a precipitation step of preparing fraction ii from fraction i+ii+iii or fraction ii+iii as a starting material can be omitted, and problems, including a complicated process and a low yield, which occur in the conventional preparation process employing the polyethylene glycol treatment process, can be solved by use of first sodium caprylate precipitation, anion exchange chromatography and cation exchange chromatography.
Green Cross Holdings Corporation

Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature

A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed in the presence of a water miscible organic modifier and at an elevated temperature followed by reverse phase chromatography performed in the presence of a water miscible organic modifier and at an elevated temperature.. .
Merck Sharp & Dohme Corp.

Optimized antibody capturing by mixed mode chromatography

Herein is reported a method for the purification of an antibody directly captured from clarified cell culture supernatants using streamline cst and/or capto mmc, wherein especially product related (aggregates and fragments) and process related impurities (host cell protein, media components) could efficiently be removed, resulting in a preparation with a purity comparable to classical protein a affinity chromatography.. .
Hoffmann-la Roche Inc.

Resist overlayer film forming composition and producing semiconductor device including the same

A resist overlayer film forming composition for use in a lithography process in semiconductor device production does not intermix with a resist, blocks undesirable exposure light particularly in euv exposure, for example, uv and duv and selectively transmits euv alone, and can be developed with a developer after exposure. A resist overlayer film forming composition includes: a polymer (p) including unit structures of formula (1) and formula (2) and having a weight average molecular weight, measured by gel permeation chromatography, of 500 to 2,000; and a c8-16 ether compound as a solvent:.
Nissan Chemical Industries, Ltd.

Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system

A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (gc-ms) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the gc-ms system, at a location between a high vacuum end of a transfer line and a mass analyzer of the gc-ms system.
Thermo Finnigan Llc

Multiple column chromatographic system and methods of use

A chromatographic apparatus includes two chromatographic columns configured to perform chromatography. The apparatus further includes a primary valve disposed upstream of the first chromatographic column and the second chromatographic column.
BÜchi Labortechnik Ag

Method for purification of 225ac from irradiated 226ra-targets

The present invention describes a method for purification of 225ac from irradiated 226ra-targets provided on a support, comprising a leaching treatment of the 226ra-targets for leaching essentially the entirety of 225ac and 226ra with nitric or hydrochloric acid, followed by a first extraction chromatography separating 25ac from 226ra and other ra-isotopes and a second extraction chromatography for separating 225ac from 210po and 210pb. The finally purified 225ac can be used to prepare compositions useful for pharmaceutical purposes..
Actinium Pharmaceuticals Inc.

In-situ heated deposition of parylene to enhance pore penetration into silicone

A composition of matter is described in which a porous material, such as polydimethylsiloxane (pdms), is coated with parylene n, c, d, or af-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° c. And 120° c., or 80° c.
California Institute Of Technology

Method for purifying pegylated erythropoietin

Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange sp sephacryl™ s 500 hr chromatography material conditioned to a conductivity of 21 ms/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield..
Hoffmann-la Roche Inc.

Packing material for liquid chromatography and column for liquid chromatography

A packing material for liquid chromatography, which is excellent in durability, and a column for liquid chromatography, which is filled with the packing material, are provided. The packing material for liquid chromatography is characterized by comprising a hydrophilic resin containing a polyvinyl alcohol resin, to said hydrophilic resin an amino group represented by the formula (1) having been bonded through a spacer.
Showa Denko K.k.

Plug unit and connection system for connecting capillary tubes, especially for high-performance liquid chromatography

A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit.
Dionex Softron Gmbh

Method for purifying and renaturating inclusion bodies of scorpion toxin protein and their use

A method for purifying and renaturating inclusion bodies of scorpion venom protein is provided. The method includes expressing the scorpion venom protein by recombinant escherichia coli.
Guangzhou Glam Biotechnology Co., Ltd.

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Sampler for liquid chromatography

A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop.
Dionex Softron Gmbh

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Highly aromatic base oil and producing highly aromatic base oil

A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 mpa, a temperature of 280 to 400° c., a hydrogen oil ratio of 300 to 750 nl/l, and a space velocity of 0.3 to 2.0 h−1.
Jx Nippon Oil & Energy Corporation

Colorant compounds derived from genipin or genipin containing materials

The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material.
Ecoflora S.a.s.

Protein purification

A method for purifying a polypeptide by ion exchange chromatography is described which involves changing the conductivity and/or ph of buffers in order to resolve a polypeptide of interest from one or more contaminants.. .
Genentech, Inc.

Separation of bispecific antibodies and bispecific antibody production side products using hydroxyapatite chromatography

The present invention is directed to methods comprising the use of hydroxyapatite chromatography to separate a bispecific antibody from a solution that also comprises one or more byproducts specific to bispecific antibody production. Byproducts specific to the production of bispecific antibodies (bispecific antibody specific byproducts, “basb”) include fragments of the bispecific antibody and heavier molecular weight variants of the antibody, wherein the fragment and/or variant comprises an fc domain but does not exhibit affinity for the two different epitopes and/or antigens as exhibited by the desired bispecific antibody.
Hoffmann-la Roche Inc.

Purification of staphylococcus aureus type 5 and type 8 capsular saccharides

The invention provides a method for releasing capsular polysaccharide from s. Aureus type 5 or type 8 cells, comprising the step of treating the cells with acid.
Glaxosmithkline Biologicals Sa



Chromatography topics:
  • Chromatography
  • Chromatograph
  • Antibodies
  • Mass Spectrometry
  • Spectrometry
  • Quantitative
  • High Resolution
  • Switching Valve
  • Cross Section
  • Protein A Affinity Chromatography
  • Amino Acid
  • Silica Gel
  • Carboxylic Acid
  • Antifungal
  • Isoleucine


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    This listing is a sample listing of patent applications related to Chromatography for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Chromatography with additional patents listed. Browse our RSS directory or Search for other possible listings.


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