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Chromatography patents

      

This page is updated frequently with new Chromatography-related patent applications.




 Column manager with a multi-zone thermal system for use in liquid chromatography patent thumbnailColumn manager with a multi-zone thermal system for use in liquid chromatography
A thermal system for use in a column manager of a liquid chromatography system comprises a plurality of spatially separated individually controlled thermoelectric chips. A column module houses a plurality of thermally conductive troughs.
Waters Technologies Corporation


 Seal assembly for supercritical fluid chromatography patent thumbnailSeal assembly for supercritical fluid chromatography
A seal assembly for pressurized fluid applications, including supercritical fluid chromatography applications, includes an annular body and a helical wound flat spring. A bore extends through the annular body.
Waters Technologies Corporation


 Purification of iduronate-2-sulfatase patent thumbnailPurification of iduronate-2-sulfatase
The present invention provides, among other things, improved methods for purifying i2s protein produced recombinantly for enzyme replacement therapy. The present invention is, in part, based on the surprising discovery that recombinant i2s protein can be purified from unprocessed biological materials, such as, i2s-containing cell culture medium, using a process involving as few as four chromatography columns..
Shire Human Genetic Therapies, Inc.


 Method for preparing human plasma proteins patent thumbnailMethod for preparing human plasma proteins
The invention relates to a method for preparing plasma protein concentrate from blood plasma by means of multicolumn chromatography.. .
Laboratoire Francais Du Fractionnement Et Des Biotechnologies


 Refined plant isolates and process for the manufacture of a functional food ingredient from such plant isolate patent thumbnailRefined plant isolates and process for the manufacture of a functional food ingredient from such plant isolate
The present invention is concerned with providing refined plant isolates that can be used as starting materials for the production of functional food ingredients, such as taste enhancers, through an isolation process that employs ion exclusion chromatography. More particularly, the present invention provides a refined plant isolate comprising at least 30% by weight of dry matter of water soluble plant components selected from fructose, glucose, proteinaceous matter of plant origin, acids and potassium, said isolate further being characterized in that at a concentration of 40° brix the isolate: •contains at least 0.3 wt % of glutamate; •contains at least 500 ppm of k+; •contains less than 300 ppm of ca2+; •contains less than 700 ppm of mg2+; •contains less than 1 wt.
Conopco Inc., D/b/a Unilever


 Methods of evaluating quality of media suitable for removing anti-a or anti-b antibodies patent thumbnailMethods of evaluating quality of media suitable for removing anti-a or anti-b antibodies
Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-a or anti-b antibodies from a sample, where the methods employ use of purified lectins.. .
Merck Patent Gmbh


 Methods of evaluating quality of a chromatography media which binds anti-a or anti-b antibodies patent thumbnailMethods of evaluating quality of a chromatography media which binds anti-a or anti-b antibodies
Embodiments described herein relate to methods of evaluating quality of a chromatography media for removal of anti-a or anti-b antibodies from a sample, where the methods employ use of purified monoclonal igm-a and igm-b antibodies.. .
Merck Patent Gmbh


 Portable spectroscopic analysis tool patent thumbnailPortable spectroscopic analysis tool
A portable spectroscopy analysis tool tests food for herbicides, pesticides, growth hormones, carcinogens, and other materials. Due to the broad range of herbicides, pesticides, growth hormones, carcinogens, and other materials which may be subjects of concern for the user, and the immediate need for accurate test results based on a small sample, the tool preferably employs gas chromatography-mass spectrometry (gc-ms).

 Flash chromatography cartridge patent thumbnailFlash chromatography cartridge
A low pressure liquid chromatographic cartridge has a tubular polymer container that receives a chromatographic packing material. The container has an outlet port located at its downstream end and container threads formed on its upstream end.
Scientific Plastics Products, Inc.


 Temperature-responsive monolithic porous body,  producing same, and temperature-responsive chromatography method using same patent thumbnailTemperature-responsive monolithic porous body, producing same, and temperature-responsive chromatography method using same
A temperature responsive monolithic porous material is obtained that comprises a polymer having a hydration ability that changes in a temperature range of 0 to 80° c. And being immobilized to a surface of the porous material at a high density by binding an atom transfer radical polymerization initiator to a surface of the porous material, and inducing a growth reaction of a polymer, having a hydration ability that changes in a temperature range of 0 to 80° c., from the initiator using an atom transfer radical process under a presence of a catalyst..
Tokyo Women's Medical University


Method for endotoxin removal

The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.. .
Ge Healthcare Bioprocess R&d Ab

Novel affinity chromatography media for removal of anti-a and/or anti-b antibodies

Embodiments described herein relate to novel chromatography media for removing anti-a and/or anti-b antibodies from a sample, as well as methods of using the same. The media described herein have several advantages over previously described media including, acid and alkaline stability..
Merck Patent Gmbh

Isoform enriched antibody preparation and obtaining it

Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an antibody to a cation exchange chromatography material, b) applying a first solution with a first conductivity to the cation exchange chromatography material, whereby the antibody isoforms remain bound to the cation exchange chromatography material, and c) applying a second solution with a second conductivity to the cation exchange chromatography material and thereby obtaining the antibody preparation, whereby the conductivity of the second solution exceeds the conductivity of the first solution by not more than 10%.. .
Hoffmann-la Roche Inc.

Process for the isolation of 1,2,5,6-hexanetetrol from sorbitol hydrogenolysis reaction mixtures using simulated moving bed chromatography

A method of isolating and purifying 1,2,5,6 hexanetetrol (hto) from a reaction mixture containing hto and other byproducts of a hydrogenation reaction of a sugar alcohol and/or a mono- or di-dehydrative product of a sugar alcohol is described. The method involves contacting the mixture comprising hto and other c1-c6 alcohols and polyols with a resin material adapted for chromatography under conditions where hto preferentially associates with the resin relative to other components in the mixture, and eluting hto from said resin with a solvent..
Archer Daniels Midland Company

Continuous process for separation of proteins

Disclosed is a continuous process for separating or extracting proteins from a low grade mixture of a protein of interest, other proteins, impurities, and salts in a continuous simulated moving bed separation process. The invention provides for direct extraction of heme protein and plant protein from a crude mixture of such proteins, other proteins, impurities and salts using the chromatographic technique of simulated moving bed (smb) continuous chromatography.
Orochem Technologies, Inc.

Botanical identification method and system

The disclosure provides a method for extracting, separating, and identifying compounds from natural products, such as cannabis or hops, where separation uses gas chromatography (gc). The method includes spiking the composition to be identified with at least two markers that bracket the migration position of at least one of the compounds to be identified, where gc method uses more than one ramping step..
Scientific Holdings, Llc

Novel methods and kits for detecting of urea cycle disorders using mass spectrometry

The present invention relates to newborn screening kits, methods, stable isotopically-labeled internal standards or internal standard solution for high throughput screening and analysis of metabolic disorders using liquid chromatography mass spectrometry (lc-ms) are provided. The metabolic disorders can be amino acid, organic acid or fatty acid oxidation disorders, and particularly urea cycle disorders or deficiencies, hyperammonemia, hyperornithinemia-hyperammonemia-homocitrullinuria (hhh), and/or argininosuccinic aciduria.
Labsystems Diagnostics Oy

Method for determining prognosis of renal cell carcinoma

It is intended to provide a rapid, convenient, and highly accurate method for determining the prognosis of cancer. The present invention provides a method for determining the prognosis of a renal cell carcinoma patient, comprising: (1) treating genomic dna prepared from a renal tissue of a subject with bisulfite; (2) amplifying the bisulfite-treated dna by pcr; (3) subjecting the obtained pcr amplification product to ion exchange chromatography; (4) obtaining the retention time of a detection signal obtained by the chromatography; and (5) determining the renal cell carcinoma of the subject as having poor prognosis when the result of the step (4) is shorter than a retention time serving as a reference..
Sekisui Medical Co., Ltd.

Immunoglobulin purification using pre-cleaning steps

The present invention relates to the purification of immunoglobulins and the problem of providing a method for purifying an immunoglobulin in an efficient and cost-effective manner and with satisfactory purity and yield. In particular, the present invention addresses the aspect of the re-use of the rather cost-intensive chromatography materials, in particular the lifetime of the chromatography materials used in the capture step of the downstream process, and how this can be increased while reducing the technical complexity of the purification process..
Richter Gedeon Nyrt.

Il-15/il-15ralpha based conjugates purification method

The present invention relates to a method for preparing a composition comprising monomeric conjugates from a sample, said conjugate comprising (a) a polypeptide comprising the amino acid sequence of interleukin 15 or derivatives thereof, and (b) a polypeptide comprising the amino acid sequence of the sushi domain of il-15rα or derivatives thereof; wherein said method comprises the use of anion-exchange chromatography followed by a hydrophobic interaction chromatography; and to a pharmaceutical composition which can be obtained by such a method.. .
Cytune Pharma

Functionalized support material and methods of making and using functionalized support material

Methods of making functionalized support material are disclosed. Functionalized support material suitable for use in chromatography columns or cartridges, such as in a high pressure liquid chromatography (hplc) column or a fast protein liquid chromatography (fplc) column, is also disclosed.
W. R. Grace & Co.-conn.

Ghrelin o-acyltransferase inhibitors

Small molecule ghrelin o-acyltransferase inhibitors found using an assay to detect ghrelin o-acyltransferase activity using an acrylodan-labeled peptide mimic of ghrelin that provides for high-throughput screening for ghrelin o-acyltransferase inhibitors and detection via high performance liquid chromatography. The newly discovered class of synthetic triterpenoids efficiently inhibits ghrelin acylation by goat and function as covalent reversible inhibitors of goat.
Syracuse University

Microwave-assisted headspace liquid-phase microextraction of an analyte

A method for extracting an analyte in a sample is described. A sample and a solution in a microwave-extraction vial are microwave-heated and agitated.
King Fahd University Of Petroleum And Minerals

Method for estimating a quantity of particles divided into classes, using a chromatogram

The invention is a method for estimating a quantity or a concentration of particles using a detector disposed at the exit of a chromatography column. The estimation is carried out on the basis of a selection of a plurality of retention times within the histogram, each retention time being associated with an individual particle.
Commissariat A L'energie Atomique Et Aux Energies Alternatives

Method for estimating a retention time in a chromatography column

The invention is a method for estimating a retention time of a particle in a chromatography column, and more particularly in a chromatography column one parameter of which, such as temperature, is modulated. The retention time is estimated on a probabilistic basis by sequentially modelling the transit of the particle in the column.
Commissariat A L'energie Atomique Et Aux Energies Alternatives

Method for measuring formaldehyde in solutions containing certain formaldehyde-releasing biocides

A method for measuring formaldehyde in an aqueous solution of an oxazolidine or hexahydro-1,3,5-triazine biocide; said method comprising separating an amino alcohol produced by hydrolysis of said biocide via mixed mode chromatography and detecting said amino alcohol using a charged aerosol detector or an evaporative light scattering detector.. .
Dow Global Technologies Llc

Torque limited fitting

A torque limited fitting is provided having a head and a body, which in certain embodiments may be assembled by an operator. The body of the torque limited fitting has a passageway therethrough for receiving and removably holding tubing.
Idex Health & Science Llc

Chromatography method

The present invention relates to a method for removal of large contaminants, such as virus, in a chromatographic process for purification of a target molecule, preferably monoclonal antibodies, mabs, by using a specifically designed chromatographic bead having a thin outer layer and a core functionalized with a ligand adsorbing the mabs or parts thereof.. .
Ge Healthcare Bioprocess R&d Ab

Oil-gas separation cylinder, an oil-gas separation device and an oil chromatography

The present invention discloses an oil-gas separation cylinder, an oil-gas separation device and an oil chromatography. The oil-gas separation cylinder comprises an oil-gas separation cylinder body of which axe extends in direction of up and down, a separating block which separates the oil-gas separation cylinder body into an upper cavity and a lower cavity, an oil-gas separation cylinder piston movably installed in the lower cavity, an oil inlet passage and an oil outlet passage, and an oil-gas separation cylinder vent arranged at upper end of the upper cavity, wherein both of the oil inlet passage and the oil outlet passage are communicated with the upper cavity, wherein the separating block is provided with a guiding hole and a spaying hole used to communicate the upper cavity to the lower cavity, or the separating block is provided with a spaying hole guiding oil used to communicate the upper cavity to the lower cavity.
Xj Electric Co.,ltd

Chromatography medium

The present invention is within the field of chromatography. More precisely, it relates to a novel chromatography medium, namely a hydrophobic medium provided with different lids excluding molecules over a certain size due to the porosity of the hydrophobic medium and/or the porosity of the lid.
Ge Healthcare Bioprocess R&d Ab

Method and the equilibration of a packed chromatography column

Disclosed is a method for equilibrating a chromatography column including the steps of (i) providing a mobile phase; and (ii) passing the mobile phase through a packed chromatography column; wherein the mobile phase includes two liquids, the proportions of which change as it is passed through the column. Also discussed are automated aspects of the method, as well as a system capable of performing such method..
Biotage Ab

Systems, apparatus, and methods for analyzing and predicting cellular pathways

Integrative analysis of metabolites is essential to obtain a comprehensive view of dysregulated biological pathways leading to a disease. Despite the great potential of metabolites their system level analysis has been limited.

Glycan sample preparation

The present teachings relate to methods, systems, and kits for the preparation, purification and/or analysis of a glycan or glycoconjugate, and specifically to a magnetic bead based sample preparation protocol that can enable full automation and reduced sample preparation time relative to current methods of glycoanalysis. In some aspects, the sample preparation protocol can provide for glycoconjugate capture, glycan release, fluorescent derivatization, and glycan purification for subsequent capillary electrophoresis, liquid chromatography, or other glycoanalytical method without requiring time-consuming sample preparation steps such as centrifugation or vacuum-centrifugation..
Beckman Coulter, Inc.

Quantification of transthyretin and its isoforms

The present invention relates to assays and methods for the detection of transthyretin and its isoforms. Specifically, the assays and methods of the present invention embrace liquid chromatography and mass spectrometry.
Alnylam Pharmaceuticals, Inc.

High efficiency continuous countercurrent tangential chromatography

A system, module and method for continuous or batch single-pass countercurrent tangential chromatography are disclosed for bind/elute and negative chromatography applications. The system includes binding, washing, elution (for bind/elute), regeneration, and equilibration single-pass modules.

Wash solution comprising arginine for the affinity chromatography step in antibody purification

The invention provides a washing method for affinity chromatography in which a wash solution comprising arginine, or an arginine derivative, and a nonbuffering salt, preferably at high ph, greater than 8.0, is effective in removing impurities, such as high molecular weight species and host cell proteins, while also increasing product concentration in the eluate and maintaining a high percent yield of recovered product.. .

Preparation high-purity 4'-galactosyl-lactose composition

A composition which has high 4′-gl purity and can be used as a reference standard for various analyses can be obtained by a more convenient method than one conventionally used. A method for preparing a high-purity 4′-gl composition includes the steps of: (a) subjecting a 4′-gl-containing galacto-oligosaccharide to activated carbon column chromatography, and performing stepwise elution with plural organic solvent aqueous solutions, wherein the organic solvent aqueous solutions are used such that the concentration of the organic solvent in the organic solvent aqueous solution is higher than the concentration of the organic solvent in the immediately preceding organic solvent aqueous solution with respect to a series of elutions; and (b) adding an organic solvent to the final fraction eluted in step (a), and crystallizing the 4′-gl..
Kabushiki Kaisha Yakult Honsha

Solid-phase carrier, production solid-phase carrier, carrier for affinity refining, production filler for affinity chromatography, filler for affinity chromatography, chromatography column, and refining method

There are provided a solid-phase carrier and a carrier for affinity refining that exhibit high dynamic binding capacity when a ligand is immobilized, have excellent antifouling properties, and are unlikely to have non-specific adsorption of impurities. The solid-phase carrier has a functional group capable of fixing a ligand and is characterized by having a group having a sulfinyl group, a sulfide group, an oxy group or an imino group, and a hydroxyl group, a thiol group, an amino group, a carboxy group, a sulfate group, a phosphate group or an alkanoyl group..
Jsr Life Sciences Corporation

Process for transfer of a method from a starting system to a target system in liquid chromatography

A process for transferring a method from a starting system to a target system in liquid chromatography, in particular in high performance liquid chromatography, is described. A first chromatogram of the method carried out on the starting system is available or determined.
Dionex Softron Gmbh

Chromatography apparatus having diffusion-bonded and surface-modified components

A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet.
Waters Technologies Corporation

Plate for gas chromatograph with a capillary column, capillary device and gas chromatograph

The present invention relates to gas chromatography with capillary column and more particularly to a plate for gas chromatograph with a capillary column, a capillary device and a gas chromatograph comprising such capillary device. At least one face of the plate is etched with a furrow forming a first part of the capillary column.
Total Sa

Gas chromatograph column connection device

A column connection device for use in gas chromatography is disclosed. The column connection device includes a housing with a piston, a piston spring retainer, and disk springs composed of an austenite nickel-chromium-based superalloy (e.g.
Perkinelmer Health Sciences, Inc.

Chromatography systems with mobile phase generators

Certain configurations of a gas chromatography system comprising an internal gas generator are described. In some instances, the gas chromatography system may comprise an internal hydrogen generator to provide hydrogen gas to a chromatography column for separation of analyte species.

Convectively controlled adiabatic column chamber for use in chromatographic systems

A column-conditioning enclosure includes a column chamber adapted to hold one or more chromatography separation columns. A duct system provides an airflow path around the column chamber such that the one or more chromatography separation columns held within the column chamber are isolated from the airflow path.
Waters Technologies Corporation

Nucleic acid detection or quantification method using mask oligonucleotide, and device for same

Very simple, highly sensitive detection or quantification of target nucleic acids of interest has been achieved by: hybridizing mask oligonucleotides to regions in a single-stranded region of a nucleic acid to be assayed between which a region to be hybridized by an oligonucleotide probe is positioned, thereby opening the probe-hybridizing region and keeping the single-stranded region of the target nucleic acid stable, and then subjecting this nucleic acid having the single-stranded region to nucleic acid chromatography.. .
Fuso Pharmaceutical Industries, Ltd.

New process for the preparation of high purity prostaglandins

The subject of the invention is a process for the preparation of high purity prostaglandin acid of the general formula ii wherein the bonds marked with dotted lines represent single or double bonds wherein the double bonds may be cis- or trans oriented, y represents 0 or ch2, and r3 stands for a phenyl group which is optionally substituted with cf3, wherein the crude prostaglandin acid of the general formula ii is purified by normal phase silicagel chromatography.. .
Chinoin GyÓgyszer És VegyÉszeti TermÉkek GyÁra Zrt.

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Hoisting and holding system for chromatography column

A holding system for holding and hoisting a chromatography column of one or more chromatography columns is disclosed. The holding system includes an upright member and a plurality of holding members movably arranged along the upright member.
Ge Healthcare Bio-sciences Ab

Method and device for two-dimensional separation of ionic species

The invention relates to a method which realizes a two-dimensional separation of ionic species on the basis of the online coupling of ion chromatography (ic) and capillary electrophoresis (ce). A device for ic×ce coupling, its implementation in terms of two alternatives, the connection to a mass spectrometric detector, and corresponding application are described..
UniversitÄt Regensburg

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Novel purification process of gonadotropin

The present invention provides an improved method for the purification of desired gonadotropin from a crude mixture containing at least one contaminating protein. The process of purification of the desired gonadotropin according to the present invention comprises use of an affinity chromatography as the first column purification step, prior to use of any column chromatography steps for further purification.
Cadila Healthcare Limited



Chromatography topics:
  • Chromatography
  • Chromatograph
  • Antibodies
  • Mass Spectrometry
  • Spectrometry
  • Quantitative
  • High Resolution
  • Switching Valve
  • Cross Section
  • Protein A Affinity Chromatography
  • Amino Acid
  • Silica Gel
  • Carboxylic Acid
  • Antifungal
  • Isoleucine


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    This listing is a sample listing of patent applications related to Chromatography for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Chromatography with additional patents listed. Browse our RSS directory or Search for other possible listings.


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