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Chromatography patents

      

This page is updated frequently with new Chromatography-related patent applications.




 Optimizing operating binding capacity for a multiple column chromatography process patent thumbnailnew patent Optimizing operating binding capacity for a multiple column chromatography process
Methods for optimizing operating binding capacity for a multiple column chromatography (mcc) process are disclosed.. .
Pall Corporation


 Pressure-sensitive adhesive composition and acrylic pressure-sensitive adhesive composition patent thumbnailnew patent Pressure-sensitive adhesive composition and acrylic pressure-sensitive adhesive composition
An object of the present invention is to provide an adhesive composition that is substantially odorless and has an extremely good color and excellent adhesive properties or tack at low temperatures of about 5° c. And in which deterioration over time caused by heat or light is suppressed.
Arakawa Chemical Industries, Ltd.


 Method for purifying immunoglobulin patent thumbnailnew patent Method for purifying immunoglobulin
The present invention relates to a method for purifying an immunoglobulin, and more particularly, to a method for purifying an immunoglobulin, which comprises: dissolving immunoglobulin-containing plasma protein fraction i+ii+iii or fraction ii+iii; adding caprylate to the solution to cause precipitation; performing dialysis and concentration after removal of the precipitate; performing anion exchange resin and ceramic cation exchange resin purification processes to effectively remove a solvent and detergent added to inactivate viruses; and performing elution while maintaining salt concentration at a constant level to maintain the immunoglobulin polymer content at a low level. According to the method for preparing the intravenous immunoglobulin according to the present invention, a precipitation step of preparing fraction ii from fraction i+ii+iii or fraction ii+iii as a starting material can be omitted, and problems, including a complicated process and a low yield, which occur in the conventional preparation process employing the polyethylene glycol treatment process, can be solved by use of first sodium caprylate precipitation, anion exchange chromatography and cation exchange chromatography.
Green Cross Holdings Corporation


 Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature patent thumbnailnew patent Purifying insulin using cation exchange and reverse phase chromatography in the presence of an organic modifier and elevated temperature
A process is described for purifying insulin and insulin analogs that comprises high-pressure liquid chromatography with an acidic cation exchange medium performed in the presence of a water miscible organic modifier and at an elevated temperature followed by reverse phase chromatography performed in the presence of a water miscible organic modifier and at an elevated temperature.. .
Merck Sharp & Dohme Corp.


 Optimized  antibody capturing by mixed mode chromatography patent thumbnailnew patent Optimized antibody capturing by mixed mode chromatography
Herein is reported a method for the purification of an antibody directly captured from clarified cell culture supernatants using streamline cst and/or capto mmc, wherein especially product related (aggregates and fragments) and process related impurities (host cell protein, media components) could efficiently be removed, resulting in a preparation with a purity comparable to classical protein a affinity chromatography.. .
Hoffmann-la Roche Inc.


 Resist overlayer film forming composition and  producing semiconductor device including the same patent thumbnailResist overlayer film forming composition and producing semiconductor device including the same
A resist overlayer film forming composition for use in a lithography process in semiconductor device production does not intermix with a resist, blocks undesirable exposure light particularly in euv exposure, for example, uv and duv and selectively transmits euv alone, and can be developed with a developer after exposure. A resist overlayer film forming composition includes: a polymer (p) including unit structures of formula (1) and formula (2) and having a weight average molecular weight, measured by gel permeation chromatography, of 500 to 2,000; and a c8-16 ether compound as a solvent:.
Nissan Chemical Industries, Ltd.


 Method and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system patent thumbnailMethod and system for decoupling a capillary column from a gas chromatography-mass spectrometry (gc-ms) system
A column-sealing tool is provided for use during decoupling of a capillary column from a gas chromatography-mass spectrometry (gc-ms) system. The column-sealing tool includes an engagement structure for removably securing the column-sealing tool within a high vacuum enclosure of the gc-ms system, at a location between a high vacuum end of a transfer line and a mass analyzer of the gc-ms system.
Thermo Finnigan Llc


 Multiple column chromatographic system and methods of use patent thumbnailMultiple column chromatographic system and methods of use
A chromatographic apparatus includes two chromatographic columns configured to perform chromatography. The apparatus further includes a primary valve disposed upstream of the first chromatographic column and the second chromatographic column.
BÜchi Labortechnik Ag


 Method for purification of 225ac from irradiated 226ra-targets patent thumbnailMethod for purification of 225ac from irradiated 226ra-targets
The present invention describes a method for purification of 225ac from irradiated 226ra-targets provided on a support, comprising a leaching treatment of the 226ra-targets for leaching essentially the entirety of 225ac and 226ra with nitric or hydrochloric acid, followed by a first extraction chromatography separating 25ac from 226ra and other ra-isotopes and a second extraction chromatography for separating 225ac from 210po and 210pb. The finally purified 225ac can be used to prepare compositions useful for pharmaceutical purposes..
Actinium Pharmaceuticals Inc.


 In-situ heated deposition of parylene to enhance pore penetration into silicone patent thumbnailIn-situ heated deposition of parylene to enhance pore penetration into silicone
A composition of matter is described in which a porous material, such as polydimethylsiloxane (pdms), is coated with parylene n, c, d, or af-4 by vapor deposition polymerization while a temperature of the porous material's surface being coated is heated to between 60° c. And 120° c., or 80° c.
California Institute Of Technology


Method for purifying pegylated erythropoietin

Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange sp sephacryl™ s 500 hr chromatography material conditioned to a conductivity of 21 ms/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield..
Hoffmann-la Roche Inc.

Packing material for liquid chromatography and column for liquid chromatography

A packing material for liquid chromatography, which is excellent in durability, and a column for liquid chromatography, which is filled with the packing material, are provided. The packing material for liquid chromatography is characterized by comprising a hydrophilic resin containing a polyvinyl alcohol resin, to said hydrophilic resin an amino group represented by the formula (1) having been bonded through a spacer.
Showa Denko K.k.

Plug unit and connection system for connecting capillary tubes, especially for high-performance liquid chromatography

A plug unit for connecting capillary tubes includes a plug housing that has an axial borehole, a plug capillary tube that projects through the axial borehole, and a sealing element that surrounds the plug capillary tube. The front end of the plug capillary tube is sealed by an elastic and/or plastic deformation of the sealing element against the capillary tube receptacle opening of a bushing unit.
Dionex Softron Gmbh

Method for purifying and renaturating inclusion bodies of scorpion toxin protein and their use

A method for purifying and renaturating inclusion bodies of scorpion venom protein is provided. The method includes expressing the scorpion venom protein by recombinant escherichia coli.
Guangzhou Glam Biotechnology Co., Ltd.

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Sampler for liquid chromatography

A sampler for liquid chromatography is described. The sampler includes an injection valve and a sample loop.
Dionex Softron Gmbh

Vacuum ultraviolet absorption spectroscopy system and method

An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.

Highly aromatic base oil and producing highly aromatic base oil

A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 mpa, a temperature of 280 to 400° c., a hydrogen oil ratio of 300 to 750 nl/l, and a space velocity of 0.3 to 2.0 h−1.
Jx Nippon Oil & Energy Corporation

Colorant compounds derived from genipin or genipin containing materials

The present disclosure provides colorant compounds and methods of isolation of the colorant compounds derived from a reaction of genipin and an amine. The colorant compositions comprise purified compounds (e.g., a purified polymer or a purified dimer) obtained from multiple fractioning by chromatography of the reaction resulting material.
Ecoflora S.a.s.

Protein purification

A method for purifying a polypeptide by ion exchange chromatography is described which involves changing the conductivity and/or ph of buffers in order to resolve a polypeptide of interest from one or more contaminants.. .
Genentech, Inc.

Separation of bispecific antibodies and bispecific antibody production side products using hydroxyapatite chromatography

The present invention is directed to methods comprising the use of hydroxyapatite chromatography to separate a bispecific antibody from a solution that also comprises one or more byproducts specific to bispecific antibody production. Byproducts specific to the production of bispecific antibodies (bispecific antibody specific byproducts, “basb”) include fragments of the bispecific antibody and heavier molecular weight variants of the antibody, wherein the fragment and/or variant comprises an fc domain but does not exhibit affinity for the two different epitopes and/or antigens as exhibited by the desired bispecific antibody.
Hoffmann-la Roche Inc.

Purification of staphylococcus aureus type 5 and type 8 capsular saccharides

The invention provides a method for releasing capsular polysaccharide from s. Aureus type 5 or type 8 cells, comprising the step of treating the cells with acid.
Glaxosmithkline Biologicals Sa

Method for treatment of disease with pure porcine monosialoganglioside gm1

A process for preparing pure monosialoganglioside gm1 in the form of its sodium salt. There is provided a process for the isolation and purification of monosialoganglioside gm1 comprising (a) separation of gm1 from a lipidic mixture containing the monosialoganglioside gm1 as the main ganglioside component by ion exchange column-chromatography using an eluent comprising potassium or caesium ions, (b) recovery of the solute from the eluted solution, (c) diafiltration of an aqueous solution of the recovered solute, and (d) second diafiltration after the addition of 1 m nacl, and recovering gm1.
Laboratoire Medidom Sa

Electrostatic image developing toner

Provided is an electrostatic image developing toner comprising a toner base particle containing a binder resin and a releasing agent, wherein the binder resin comprises an amorphous vinyl resin and a crystalline polyester resin; a weight-average molecular weight of the electrostatic image developing toner is in the range of 50000 to 90000, when calculated from a chromatogram which represents a molecular weight distribution and is measured by gel permeation chromatography; a ratio of content of a resin component having a molecular weight of 100000 or more is in the range of 10 to 20% by area, in the chromatogram which represents the molecular weight distribution; the crystalline polyester resin has a melting point in the range of 65 to 85° c.; and, a ratio of content of the crystalline polyester resin in the binder resin is in the range of 5 to 20% by mass.. .
Konica Minolta, Inc.

Hemolytic streptococcus diagnostic immunochromatography reagent, kit, and detection method

Disclosed herein is an immunoassay method for detecting the detection target antigen in an analyte through extraction with an extraction agent. The method is characterized in that the detection is performed in the presence of a cyclic oligosaccharide.
Tranaka Kikinzoku Kogyo K.k.

Ion exchange chromatography column, method, and system thereof

An ion exchange chromatographic packing material is described that includes support resin particles and a copolymer grafted to the support resin particles. The copolymer includes polymerized functional monomers such as a first ion exchange group monomer and a second ion exchange group monomer.
Dionex Corporation

Determination of chromatography conditions

The invention also relates to a system for performing the method as well as a computer program and an instrument comprising such a computer program.. .

Packing material for hydrophilic interaction chromatography

The present invention provides a packing material for hydrophilic interaction chromatography consisting of a modified support treated with the surface modifier represented by the following formula (6) or (7). (in this formula, m denotes 2-6 and n denotes 1-4.

Method for detailed and bulk classification analysis of complex samples using vacuum ultra-violet spectroscopy and gas chromatography

Analysis of chemically samples using gas chromatography (gc) separation with vacuum ultra-violet spectroscopy detection is described. One technique focuses on assigning a specific analysis methodology to each constituent in a sample.
Vuv Analytics, Inc.

Method for purifying stearidonic acid

The present invention relates to a method for producing and purifying sda at high purity and/or high yield from a raw material such as anchovy oil. According to the present invention, when separating and purifying sda from a raw material (e.g.
Bizen Chemical Co., Ltd.

Multi-dimensional chromatographic methods for separating n-glycans

A multi-dimensional chromatographic method for the separation of n-glycans. The method comprises providing a glycan preparation that includes at least one negatively charged n-glycan.
Momenta Pharmaceuticals, Inc.

Compositions and methods for analysis of protein sequences and post-translational modifications

The application discloses, compositions, methods, systems, and apparatuses for rapid sequence analysis of proteins, including location of post-translational modifications and disulfide bonds, is described. Limited digestion of fully denatured antibody occurs in seconds by flowing sample in 8 m urea at constant pressure through a micro column reactor containing immobilized aspergillopepsin i, resulting in a product mixture containing 3-10 kda peptides, which is then fractionated by capillary column chromatography and analyzed by both electron transfer dissociation (etd) and collision activated dissociation mass spectrometry.
University Of Virginia Patent Foundation

Method for measuring human exhaled air

A method for measuring human exhaled air by means of gas chromatography and ion mobility spectrometry, wherein an exhaled air sample enters a sample loop via a sample inlet and a multi-port valve and is subsequently conveyed by means of a carrier gas from the sample loop, via the multi-port valve through a gas chromatographic column, into an ion mobility spectrometer, and measured, which method is to provide reliable and accurate measurement results. This object is achieved in that the following steps are carried out before an exhaled air sample is introduced into the sample loop: (a) first flushing at least the gas chromatographic column, the ion mobility spectrometer and the sample loop with a flushing gas and then switching the multi-port valve in such a way that the flushing gas enters the ion mobility spectrometer and is measured; (b) then stopping the supply of flushing gas and switching the multi-port valve in such a way that ambient air flows through the gas chromatographic column into the ion mobility spectrometer and is measured; (c) then flushing at least the gas chromatographic column, the ion mobility spectrometer and the sample loop with humidified flushing gas and switching the multi-port valve in such a way that the humidified flushing gas enters the ion mobility spectrometer and is measured; and (d) subsequently stopping the supply of humidified flushing gas, conducting an exhaled air sample into the sample loop, conveying the sample, by means of the carrier gas, through the gas chromatographic column into the ion mobility spectrometer, and measuring the sample..
Imspex Diagnostics Ltd

Methods for mass spectrometric quantitation of analytes extracted from a microsampling device

Mass spectrometric methods are described for determining the amount of analyte in a sample collected by a microsampling device. Provided herein are methods directed to quantitating the amount of an analyte in a sample by extracting an analyte from a sample collected by a microsampling device, purifying the sample by liquid chromatography, ionizing the analyte to generate one or more ions detectable by mass spectrometry; and determining the amount of the one or more ions by mass spectrometry.
Quest Diagnostics Investments Llc

A bioreactor arrangement and continuous process for producing and capturing a biopolymer

The present invention relates to a bioreactor arrangement for producing a biopolymer expressed by a cell and a continuous process for a capturing the biopolymer employing two chromatography units operated in series or independently.. .
Cmc Biologics A/s

Method for separating hyaluronan and quantifying its molecular mass distribution in biological samples

The present invention provides a facile method for separation (fractionation) of ha in a sample over a broad m range, including low m ha, by ion exchange (iex) chromatography. The present invention also provides an assay method for quantifying in a sample the presence of low m ha in total ha isolated from a biological source.
New York University

Affinity ligands and methods relating thereto

Affinity ligands useful for mild elution affinity chromatography, including affinity ligands specific for immunoglobulins m, a, and e, are disclosed as are method of identifying and using such affinity ligands.. .
Bio-rad Laboratories, Inc.

A chromatography capturing a biopolymer

The present invention relates to a chromatography system (20) wherein the chromatography system comprises an eluting system (10) and a capturing system (11) consisting of at least two chromatography units (2,3) operated alone or in series and a capturing process employing in-line buffer dilution in, which concentrated buffers are blended with water and provided to the chromatography units.. .
Cmc Biologics A/s

Process for producing and purifying factor viii and its derivatives

Disclosed is a method for producing proteins having factor viii procoagulant activity in serum-free medium by in vitro culturing of mammalian cells, wherein the serum-free medium contains an inhibitor against the protease released from cultured cells. In accordance with this invention, the inhibitor can protect the cleavage of a target protein during cultivation and increase homogeneity of a target molecule, wherein the inhibitor can be a dextran sulfate.
Sk Chemicals Co., Ltd.

Use of cation-exchange chromatography in the flow-through mode to enrich post-translational modifications

The present invention relates to improved methods in the separation recombinant polypeptides with post-translational modifications from complex mixtures through the use of a cation exchange medium.. .
Biogen Ma Inc.

Thermal conductivity detector and detector module

A thermal conductivity detector for a gas chromatograph includes a heatable resistive detector element configured to be physically arranged in a flow of analytes eluting from a chromatography column and electrically arranged together with resistors in separate arms of a measuring bridge, wherein to provide a new configuration of the thermal conductivity detector to allow high detector sensitivity and to meet intrinsic safety requirements, the detector element includes at least two equal detector sub-elements that are configured to be physically arranged in series in the flow of analytes and electrically arranged in parallel with each other, where the detector element in one arm and a reference resistor in the other arm of the same half of the measuring bridge are configured such that the total resistance of the parallel detector sub-elements at operating temperature is at least approximately equal to the resistance of the reference resistor.. .
Siemens Aktiengesellschaft

A process for manufacturing factor viii having an improved ratio of fviii:c/fviii:ag

A process for manufacturing of a factor viii product having a ratio of fviii:c/fviii:ag of at least 0.7 in the factor viii product by using chromatography wherein at least one chromatographic step is performed by means of employing; an affinity chromatography resin having an affinity for specifically binding of factor viii which is effected by an affinity ligand which is immobilised on the affinity chromatography resin, said affinity ligand is a 13 kd yeast derived fab antibody fragment directed to the factor viii molecule. An anionic chromatography resin.
Octapharma Ag

Method for purifying reduced form of beta-nicotinamide adenine dinucleotide

The present invention discloses a method for purifying reduced form of β-nicotinamide adenine dinucleotide, comprising the steps of: sequentially microfiltrating and nanofiltrating a reaction solution obtained after an enzymatic reaction, to collect a concentrate for use; then adding an ion pair reagent to the concentrate, and purifying by gradient elution using a reverse-phase chromatographic column as a stationary phase, a buffer solution as a phase a, and ethanol as a phase b; changing the cations in the purified filtrate into sodium ions by using a cation exchange resin; and nanofiltrating the filtrate obtained in step c, and finally freeze drying it in a vacuum freeze drier. In the present invention, the reduced form of β-nicotinamide adenine dinucleotide is purified by reverse phase high performance liquid chromatography and cation exchange, such that the reduced form of β-nicotinamide adenine dinucleotide has a high purity and high yield, thus meeting the requirements in industry..
Bontac Bio-engineering (shenzhen) Co., Ltd

Method for purifying oxidized form of beta-nicotinamide adenine dinucleotide

The present invention discloses a method for purifying oxidized form of β-nicotinamide adenine dinucleotide, comprising the steps of: sequentially microfiltrating and nanofiltrating a reaction solution obtained after an enzymatic reaction by using filteration membranes, to collect a concentrate for use; then adding an acid to the concentrated filtrate, to adjust the ph of the concentrate, and purifying by gradient elution using a reverse-phase chromatographic column as a stationary phase, a buffer solution as a phase a, and ethanol as a phase b; and concentrating the purified solution by nanofiltrating it with a filtration membrance, and then freeze drying it in a vacuum freeze drier. In the present invention, the oxidized form of β-nicotinamide adenine dinucleotide is purified by reverse phase high performance liquid chromatography, such that the oxidized form of β-nicotinamide adenine dinucleotide has a high purity and high yield, thus meeting the requirements in industry..
Bontac Bio-engineering (shenzhen) Co., Ltd

Toner, developer using the toner, image forming apparatus

A toner including at least a crystalline resin as a binder resin, wherein a tetrahydrofuran soluble content of the toner includes 5.0% or more as a peak area of a component having a molecular weight of 100,000 or greater in a molecular weight distribution measured by gel permeation chromatography, and the tetrahydrofuran soluble content of the toner has a weight-average molecular weight of 20,000 to 60,000.. .

Method and thermal conductivity detector

A thermal conductivity detector includes a heatable resistive detector configured to be physically arranged in an analytes flow eluting from a chromatography column and electrically arranged with resistors in separate arms of a measuring bridge, an amplifier which detects differential voltage between two opposite nodes of the bridge and applies an output voltage to other opposite nodes of the measuring bridge to maintain the detector at a constant operating temperature, and an additional resistor with a controllable switch in parallel connected in series with the detector or resistor arranged in one arm of the bridge, where the switch is periodically turned on and off at a predetermined duty cycle and/or controlled by information on characteristic times-of-arrival of analytes at the detector to compensate for operating temperature uncertainties due to manufacturing variations of the resistors and/or to allow for processing small and large peaks of a chromatogram with highest available resolution.. .
Siemens Aktiengesellschaft

Method of purifying monoclonal antibodies

A new platform method to purify plant-based monoclonal antibodies is provided. Such a method includes an antibody purification platform that involves a standardized procedure for the production of a wide array of different antibodies within a simplified context.
Kentucky Bioprocessing, Inc.

Purification of erythropoietin

In the present invention a method for purifying erythropoietin comprising at least one chromatography step using a stationary phase containing hydroxyapatite is reported. The method comprises the following steps i) the erythropoietin in a solution containing calcium-ions is brought into contact with a stationary phase containing hydroxyapatite equilibrated with a solution containing calcium-ions and namely under conditions under which the erythropoietin binds to the stationary phase containing hydroxyapatite, ii) a solution is passed over the stationary phase containing hydroxyapatite from i) which contains less calcium-ions than the previous solution and the erythropoietin is not detached from stationary phase containing hydroxyapatite, and iii) a further solution which contains less than 0.5 mm calcium-ions is passed over the stationary phase containing hydroxyapatite from ii) whereby the erythropoietin is detached from the stationary phase containing hydroxyapatite..
F. Hoffmann-la Roche Ag

Affinity chromatography media and chromatography devices

chromatography media and devices containing chromatography media are disclosed. Methods of making chromatography devices and methods of using chromatography devices containing the chromatography media are also disclosed..
Repligen Corporation

Flash chromatography cartridge

A low pressure liquid chromatographic cartridge has a tubular polymer container that receives a chromatographic packing material. The container has an outlet port located at its downstream end and container threads formed on its upstream end.
Scientific Plastics Products, Inc.

Novel pure substance extracting method

The present invention provides a novel pure substance extracting method. Differing from conventional pure substance extracting method utilizing chromatography technique to treat a red mold product with an extracting and purifying process by using a plurality of organic extracting solution, the present invention merely utilizes water and ethanol solution to extract the pure substances of monascin and ankaflavin from the red mold product.
Sunway Biotech Co., Ltd



Chromatography topics:
  • Chromatography
  • Chromatograph
  • Antibodies
  • Mass Spectrometry
  • Spectrometry
  • Quantitative
  • High Resolution
  • Switching Valve
  • Cross Section
  • Protein A Affinity Chromatography
  • Amino Acid
  • Silica Gel
  • Carboxylic Acid
  • Antifungal
  • Isoleucine


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    This listing is a sample listing of patent applications related to Chromatography for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Chromatography with additional patents listed. Browse our RSS directory or Search for other possible listings.


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