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Chromatography patents



      
           
This page is updated frequently with new Chromatography-related patent applications. Subscribe to the Chromatography RSS feed to automatically get the update: related Chromatography RSS feeds. RSS updates for this page: Chromatography RSS RSS


Chromatography column

Apparatus, system and method for mass directed chromatography

Self cleaning gas-liquid separator for serial or parallel collection of liquid fractions

Date/App# patent app List of recent Chromatography-related patents
09/25/14
20140288278
 Chromatography process for resolving heterogeneous antibody aggregates patent thumbnailnew patent Chromatography process for resolving heterogeneous antibody aggregates
Disclosed are methods and processes utilizing multi-modal chromatography as a polishing step to separate heterogeneously charged (basic and acidic) aggregates and other impurities from partially a partially purified bulk product monoclonal antibody product. The resulting chromatographic process provides a scaleable production process that is cost effective and increases the productivity of the purification process over a platform utilizing a combination of anion and cation exchange chromatography to resolve heterogeneous aggregates..
09/25/14
20140287146
 Production process of film and column for cation chromatography patent thumbnailnew patent Production process of film and column for cation chromatography
One object of the present invention is to produce a weakly acidic cation exchanger under mild conditions. Another object of the present invention is to produce a more firm weakly acidic cation exchange film.
09/25/14
20140284472
 Ion mobility spectrometer patent thumbnailnew patent Ion mobility spectrometer
A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
09/25/14
20140284279
 Apparatus, system and method for mass directed chromatography patent thumbnailnew patent Apparatus, system and method for mass directed chromatography
The present invention provides an apparatus that can be used to connect a flash chromatography instrument to a fraction collector and a mass detector to perform mass-directed flash chromatography.. .
09/25/14
20140284278
 Cationic displacer molecules for hydrophobic displacement chromatography patent thumbnailnew patent Cationic displacer molecules for hydrophobic displacement chromatography
A process for separating organic compounds from a mixture by reverse-phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic cationic displacer molecule and about 10 wt % or less of an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic cationic displacer molecule comprises a hydrophobic cation and a counterion, ci, having the general formula a or b, as defined in the disclosure:. .
09/25/14
20140284277
 Processing biomass materials patent thumbnailnew patent Processing biomass materials
Biomass (e.g., plant biomass, animal biomass, and municipal waste biomass) is processed to produce useful intermediates and products, such as energy, fuels, foods or materials. For example, equipment, systems and methods are described that can be used to treat feedstock materials, such as cellulosic and/or lignocellulosic materials.
09/25/14
20140284270
 Rna pores and methods and compositions for making and using same patent thumbnailnew patent Rna pores and methods and compositions for making and using same
Synthetic rna molecules having a pore, compositions including rna molecules having a pore, where the compositions are capable of filtering metal ions, filtering molecular ions, performing size exclusion chromatography, performing ion specific chromatography, reversible metal ion and molecular ion binding, ion selective membranes, ion selective channels, ion selective/specific sensors, electrical conduits, battery components, etc., and devices and methods for making and using same. The rnas used may be modified to improve stability.
09/25/14
20140284260
 Chromatography column patent thumbnailnew patent Chromatography column
A chromatography column having a longitudinal axis and comprising a column wall with a first end and a second end, a first end plate assembly removably connectable to said first end of the column wall, a second end plate assembly removably connectable to said second end of the column wall, wherein said first end plate assembly, said column wall and said second end plate assembly are arranged along the longitudinal axis of the column wherein the column wall, and/or first end plate assembly and/or second end plate assembly is/are rotatable about an axis of rotation wherein said axis of rotation is parallel to the longitudinal axis of said column and positioned outside the column. .
09/25/14
20140283688
 Self cleaning gas-liquid separator for serial or parallel collection of liquid fractions patent thumbnailnew patent Self cleaning gas-liquid separator for serial or parallel collection of liquid fractions
An apparatus, process, and system are disclosed that effectively provide separation of a combined gas/liquid flow stream into its separated gas and liquid factions. The invention is primarily directed to the fields of preparative supercritical fluid chromatography [sfc] and supercritical fluid extraction [sfe], but will have other utilization and applicability where phases of dramatically different density, viscosity and volumetric flow require separation..
09/18/14
20140275594
 New process for reducing pollutants in fats and oils and their derivatives patent thumbnailNew process for reducing pollutants in fats and oils and their derivatives
The present invention describes a process to reduce or eliminate at least one pollutant in a starting material, said starting material is at least one of an oil, a fat, its derivatives and mixtures thereof, of animal, krill, algae or microbial origin or biofuel, being totally or partially esterified or transesterified, or of vegetable origin, being raw, esterified or transesterified, to which optionally it is added a fluid, said fluid is at least one of an ester, a partial glyceride, a monoglyceride, a diglyceride and mixtures thereof, subjecting the starting material to at least one stage of extraction or chromatography or distillation. The process of the invention provides a product suitable to be used in food, pharmacy, cosmetic and as a dietary supplement..
09/18/14
20140275494
Protein purification using displacement chromatography
Disclosed herein are compositions and methods for the isolation and purification of proteins from a sample. In particular, the present invention relates to compositions and methods for isolating and purifying proteins incorporating a displacement chromatographic step.
09/18/14
20140275438
Bulk hydrophilic functionalization of polyamide 46
A modified polymer as result of a bulk functionalization of polyamide 46 (pa 46) is presented, as well as methods for synthesizing the modified polymer. This functionalization of pa 46 is performed to provide a homogenous semi-permeable polyamide 46 capable of different charges and different porosities with particles of nanoscale size in order to replace or improve other polyamide fibers used in the textile industry, filtering processes, selective sorption, controlled release devices, phase transfer catalysts, chromatography media, biocompatible capsules, artificial skins, organs, bone void repair as well as in cell bioreactors and incubators, dental implements, medical devices, clothing, detectors, perfusion devices, in regenerative medicine, and fuel cells..
09/18/14
20140274782
Affinity reagents and methods for detection, purification, and proteomic analysis of methylated proteins
Methyl-lysine affinity reagents created by engineering the 3×mbt methyl-lysine binding domain repeat of lethal (3) malignant brain tumor-like protein 1 (l3mbtl1) are disclosed. In particular, the invention relates to affinity reagents and affinity chromatography media comprising the 3×mbt domain repeat and methods of using such affinity reagents in detection, purification, and proteomic profiling of methylated proteins and peptides..
09/18/14
20140274751
Chemical identification using a chromatography retention index
Provided herein is technology relating to identifying unknown compounds and particularly, but not exclusively, to methods and systems for identifying unknown compounds by gas chromatography-mass spectrometry by use of retention index as a second dimension for identification.. .
09/18/14
20140273271
Fluorescence immuno-chromatography, kit and test strip for the same
Detecting another fluorescence components not exceeding the critical angle, the another fluorescence components being included in the fluorescence emitted from the fluorescent substance, the detection being made by virtue of the fluorescence components passing through the film.. .
09/18/14
20140273264
Epoxy chemistry derived materials as mixed mode chromatography media, method for their synthesis and use
This invention provides mixed-mode stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations..
09/18/14
20140273158
Chromatography membranes stable under caustic conditions
Disclosed are composite materials and methods of using them for chromatography. The composite materials retain their performance characteristics, such as binding capacity, flux, or percent recovery, under caustic conditions (e.g., 1 m naoh for 24 h).
09/18/14
20140268154
Chromatography system, signal processing apparatus, chromatography data processing apparatus, and program
A chromatography system has a multi-channel detection device including a flow cell, optics for directing light from light sources to the flow cell and outputting light that has passed through the flow cell, and a multi-channel detector. The optics has a function of dispersing light in wavelength in an optical path.
09/18/14
20140264003
Method for cleaning an atmospheric pressure chemical ionization source
Build-up of surface contamination within an atmospheric pressure chemical ionization (apci) source of a mass spectrometer (ms) is reversed by switching the apci polarity to the opposite setting used for analyte ionization after the analytes have been ionized and measured. A solvent or mixture of solvents is passed through the ion source during the opposite-polarity operation.
09/18/14
20140263012
Parallel assembly of chromatograpy column modules
A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.. .
09/18/14
20140261868
Bottle pressurization delivery system
A container assembly for use with a high-pressure liquid chromatography (hplc) instrument is disclosed, in which the container assembly, when coupled to a source of pressurized gas, provides fluid medium to the hplc instrument at positive pressure. The container assembly has an external exterior container shell, an internal fluid container for holding fluid medium, an interstitial volume between the external exterior container shell and the internal fluid container, a port for fluidly connecting the volume to a pressurized gas source, and a port for fluidly connecting the internal fluid container to the hplc instrument.
09/18/14
20140261397
Method of separating carbohydrate
Disclosed is a method of separating carbohydrate, including: mixing formic acid with heteropoly acid, chloride or bromide of lithium, magnesium, calcium, zinc, or iron, or combinations thereof to form a mixing liquid. The method also includes dissolving a cellulose biomass by the mixing liquid to form a solution, mixing water and the solution to hydrolyze the cellulose biomass for forming a carbohydrate solution, and mixing an extractant and the carbohydrate solution to extract the formic acid out of the carbohydrate solution.
09/18/14
20140260563
Epoxy chemistry derived materials as reversed-phase and hydrophobic interaction chromatography media, method for their synthesis and use
This invention provides aqueous-compatible, polar-embedded reversed-phase stationary phase compositions, devices and systems comprising the stationary phases as well as methods of producing these compositions using epoxide ring-opening reactions. Also provided are methods of using the stationary phases of the invention in separations..
09/18/14
20140260540
Sample inlet with multi-capillary liner for gas chromatography
A gas chromatograph (gc) inlet device includes a multi-capillary liner capable of separating components of a sample matrix prior to injecting the sample into an analytical gc column. The device is switchable between different modes, such as a normal injection modes, splitless modes, split modes, a backflush modes, and cut modes..
09/18/14
20140260535
Gas chromatographic "in column" spectroscopic analysis
A chemical detector for rapid, simultaneous detection of multiple chemicals including chemical warfare agents, toxic industrial chemicals, and explosives having one or more gas chromatography columns each with a chemosorbent or a chemo-reactive stationary phase and an infrared-transparent base, a bright infrared light source, a mechanism to direct the light source to any point along any of the columns, and an infrared sensor. Another disclosed detector has one or more gas chromatography columns each on the surface of a substrate having at least one infrared-transparent waveguide pattern, a bright infrared light source, and at least one ring resonator for each column, where each ring resonator is coated with a chemosorbent or a chemo-reactive stationary phase, and where each ring resonator spectroscopically probes the stationary phase.
09/18/14
20140260534
Biocompatible filter
An improved biocompatible filter for use in liquid chromatography systems such as hplc or uhplc the present disclosure addresses the problem of particles bypassing a filter in a liquid chromatography application by design features in the interface between the frit filter and ring that form an improved seal between the ring and frit and prevent leakage around the filter in high measure chromatography. Design features also include frit filters with an internal particle size gradient for pre-column separation activity during filtration..
09/18/14
20140260509
Method of calibrating a chromatography system
A method of calibrating, a chromatography system is described. The method includes injecting a standard into a chromatographic separator.
09/18/14
20140259616
Method for producing a fluidic connection component for chromatography
A method for producing a fluidic connection component for chromatography is described. A connection component includes a main body and at least one insert held in the main body.
09/11/14
20140256910
Neutral zwitterionic displacer molecules for hydrophobic displacement chromatography
A process for separating organic compounds from a mixture by reverse-phase displacement chromatography, including providing a hydrophobic stationary phase; applying to the hydrophobic stationary phase a mixture comprising organic compounds to be separated; displacing the organic compounds from the hydrophobic stationary phase by applying thereto an aqueous composition comprising a non-surface active hydrophobic neutral zwitterionic displacer molecule and optionally an organic solvent; and collecting a plurality of fractions eluted from the hydrophobic stationary phase containing the separated organic compounds; in which the non-surface active hydrophobic neutral zwitterionic displacer molecule comprises a hydrophobic zwitterion having the general formula, as defined in the disclosure: [cm-r*—cm′].. .
09/11/14
20140256899
Polymer films having improved heat sealing properties
A polymer composition comprising an ethylene alpha-olefin copolymer, wherein the polymer composition is characterized as having (a) a density in the range of from greater than about 0.910 g/cc to about 0.930 g/cc, as determined according to astm d1505; (b) a melt index in the range of from greater than about 0.5 g/10 min to about 3 g/10 min, as determined by astm d1238, condition 190° c./2.16 kg; (c) a molecular weight distribution of from about 3.4 to about 12, as determined by gel permeation chromatography (gpc); (d) a weight average molecular weight of from greater than about 85 kg/mol to about 160 kg/mol, as determined by gel permeation chromatography (gpc); and (e) a z-average molecular weight of from greater than about 210 kg/mol to about 500 kg/mol, as determined by gel permeation chromatography (gpc).. .
09/11/14
20140256673
Herbal extract composition for the treatment of diabetes and a method of extracting the same
The embodiments herein provide a method for isolation and purification of a novel oligosaccharide molecule from the fruits of rosa arvensis for the treatment of diabetes. The fruit is dried, powdered and subjected to deionized water.
09/11/14
20140255964
Analytical method of post-translational modifications in hemoglobin
An analytical method of post-translational modifications in hemoglobin is disclosed. The analytical method comprises the steps of providing a blood comprising the hemoglobin with post-translational modification of nitration, nitrosylation, or oxidation; performing an extraction process to the blood by an organic solvent; quantifying the hemoglobin by a fluorescent spectrometry; hydrolyzing the hemoglobin into a plurality of peptides by an enzyme; and using a nanoflow liquid chromatography-nano spray ionization tandem mass spectrometry to characterize and quantify the post-translational modifications of the hemoglobin..
09/11/14
20140255423
Isolation and purification of antibodies using protein a affinity chromatography
Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably protein a affinity, ion exchange chromatography, and hydrophobic chromatography.
09/11/14
20140252221
General mass spectrometry assay using continuously eluting co-fractionating reporters of mass spectrometry detection efficiency
The invention provides general methods for quantifying any conceivable compound including small organic molecules and biological molecules in mass spectrometric measurements. The methods include the use of chemical or biological reporters such as artificial polypeptides containing proteolytic cleavage sites, which provide proteolytic reporter peptides for standardization of mass spectrometric detection efficiency.
09/11/14
20140251913
System and process for biopolymer chromatography
A chromatography system for separation of a biopolymer is described, comprising at least one feed tank, at least one hold tank, at least one elution buffer tank, at least one eluate tank, at least two packed bed chromatography columns and at least one pump and at least one outlet detector both fluidically connected to said each packed bed chromatography column, wherein the feed tank, the hold tank(s), the elution buffer tank and the eluate tank are each fluidically connected to the packed bed chromatography columns via a system of valves.. .
09/11/14
20140251912
Methods and controllers for simulated moving bed chromatography for multicomponent separation
A method of separating a feed mixture in a simulated moving bed includes flowing fluid in a first flow configuration comprising: supplying the feed mixture downstream of a valve in a shut off position that stops fluid flow to a first column, removing a raffinate stream component, and supplying a remaining fluid flow to a second column; supplying a desorbent to a third column and removing an extract stream downstream; and passing a remaining liquid flow through a fourth column, and removing an intermediate stream. The method includes flowing fluid in a second flow configuration in which the valve is in a position that permits fluid flow to the first column, and supplying a desorbent and removing an extract stream downstream from the column to which the desorbent is supplied; and removing a raffinate stream.
09/11/14
20140251911
Method and apparatus for chromatographic purification
The present invention relates to a method and an apparatus suitable for a continuous chromatography process which only needs three separation columns. The process is a two step procedure comprising two chromatographic steps.
09/11/14
20140250978
Evacuable inlet for gas chromatograph injector
A gas chromatography (gc) system comprises: a sample injector adapted to receive a liquid sample into an interior cavity thereof and to volatilize the liquid sample; a gc column configured to receive the volatilized sample from the sample injector; a carrier gas inlet line fluidically coupled to a gas inlet port of the sample injector; a septum purge vent line fluidically coupled to a first gas outlet port of the sample injector; a split-flow vent line fluidically coupled to a second gas outlet port of the sample injector; and a vacuum system configured to apply vacuum to the septum purge vent line, the split-flow vent line and the interior cavity of the sample injector. Alternatively, the vacuum system may be coupled to a vacuum port of the sample injector.
09/04/14
20140249363
Method for evaluating human blastocyst by norepinephrine level in blastocyst culture solution
The invention provides a new method for evaluating transfer embryos including blastocysts used for in vitro fertilization in fertility treatment, and a method for evaluating transfer embryos using a new biomarker necessary for evaluation. The method comprises the steps of (a) providing a test object, for example, a culture solution of a human blastocyst, containing norepinephrine (noradrenaline) released from a transfer embryo, such as a human blastocyst, obtained from a subject; (b) quantitatively analyzing norepinephrine in the test object by a combination of ultra high performance liquid chromatography and mass spectrometry or the like; (c) predicting the quality of the transfer embryo based on the amount of norepinephrine from analysis results obtained; and (d) transferring the embryo into a suitable female recipient for implantation, if the transfer embryo is predicted to be of good quality and/or to lead to the establishment of a viable pregnancy based on step (c)..
09/04/14
20140249013
Centrifuge apparatus
The invention relates to centrifuge apparatus of a type which is typically, although not necessarily exclusively, for use in counter current chromatography in which substances are caused to partition between two phases in a column typically in the form of a helix or spiral. The apparatus includes leads which connect the inlet and outlet conduits to a column which is moved by the apparatus and in accordance with the invention the leads are constrained within a sheath which includes a lubricant to allow lubrication of the same while the apparatus is in use and thereby increase the longevity of the apparatus.
09/04/14
20140248196
Thin-layer chromatography plate
An object of the present invention is to provide a tlc plate which allows separation and detection of target substances on one plate. Provided is a tlc plate comprising a substrate, a separating medium layer stacked on the substrate, and a permeation layer stacked on the separating medium layer and allowing permeation of a target substance separated in the separating medium layer, wherein the separating medium layer has separating property for the target substance and optical responsiveness for ultraviolet rays, and the permeation layer has optical responsiveness different from that of the separating medium layer..
09/04/14
20140245818
Analysis method for dye for organic solar cell and purification method therefor
This analysis method includes: subjecting a sample solution of a dye-containing sample in an organic solvent to normal-phase liquid chromatography to separate the sample solution and detect separated components. The normal-phase liquid chromatography involves (b1) using a separation column filled with a column packing material which is prepared by modifying a base material with a polar modifying group, and (b2) using as an eluent a polar organic solvent containing an acid..
08/28/14
20140243548
Preparation method of 1-palmitoyl-3-acetylglycerol, and preparation method of 1-palmitoyl-2-linoleoyl-3-acetylglycerol using same
Disclosed are a method for preparing 1-palmitoyl-3-acetylglycerol in high purity and high yield without a purification process using a column chromatography, and a method for preparing 1-palmitoyl-2-linoleoyl-3-acetylglycerol in high purity and high yield using the same as a key intermediate. The method for preparing 1-palmitoyl-3-acetyl glycerol comprises the steps of: forming a reaction mixture including 1-palmitoyl-3-acetyl glycerol of the formula 1 in the specification by reacting 1-palmitoylglycerol of the formula 2 in the specification and an acetylating agent; and separating the optically active 1-palmitoyl-3-acetylglycerol by crystallizing the reaction mixture in a saturated hydrocarbon solvent having 5 to 7 carbon atoms..
08/28/14
20140243514
Method for the enrichment of rebaudioside b and/or rebaudioside d in stevia-derived glycoside compositions using adsorb-desorb chromatography with a macroporous neutral adsorbent resin
The invention relates to the use of adsorb/desorb chromatography to prepare enriched compositions comprising rebaudioside b and/or rebaudioside d. Compositions with enriched rebaudioside-b and/or rebaudioside-d components may be prepared from stevia-derived glycoside compositions using an adsorb-desorb chromatography process where the stationary phase of the chromatography bed comprises a macroporous neutral adsorbent resin..
08/28/14
20140243508
Method for the purification of antibodies
A method for the purification of immunoglobulins by ion exchange chromatography is described. The chromatographic method uses a weak ion exchange resin and a single step elution process for the purification of an immunoglobulin.
08/28/14
20140243210
Purification of immunoglobulins using affinity chromatography and peptide ligands
An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of z—r1—r2—r3—r4—r5—r6—x, is described, wherein: r1 is h or y; r2 is a hydrophobic, preferentially aromatic, amino acid (for example w, f, y, v); r3 is a positively charged or aromatic amino acid (for example r, h, f, w); r4 is a hydrophobic or positively charged amino acid (for example g, y, r, k, l); r5 is a positively charged or aromatic amino acid (for example w, f, r, h, y); r6 a random amino acid but preferably hydrophobic or negatively charged (for example v, w, l, d, h); x is present or absent and when present is a linking group; and z is present or absent and when present is a capping group bonded to the n terminus of r1; and wherein the amino acids of said peptide are in d form, l form, or a combination thereof. Methods of using such peptides for the purification of immunoglobulins are also described.
08/28/14
20140242720
Kit for immuno-chromatography, reagent for immuno-chromatography, and method of detecting using them
A kit for immunochromatography, having: a planar test strip having a test area and a reference area, the test area having a test purpose capturing substance, the reference area having a reference purpose capturing substance; fluorescent particulates provided with a binding property to a target substance, the target substance provided with a binding property to the test purpose capturing substance; and light absorbing particulates provided with a binding property to the reference purpose capturing substance.. .
08/28/14
20140242572
Chromatography method, chromatography kit, and method of producing an insoluble carrier for chromatography
A chromatography method including a step of developing a complex of a specimen and a labeled substance modified by a first bondable substance which can be bonded to the specimen on an insoluble carrier, a step of capturing the complex of the specimen and the labeled substance at a reactive site on the insoluble carrier, a step of washing the reactive site on the insoluble carrier using a washing liquid, a step of detecting the specimen which is captured at the reactive site after a signal of the labeled substance is amplified by an amplification liquid, in which the reactive site on the insoluble carrier includes (i) a second bondable substance which can be bonded to the specimen or a substance having affinity to the first bondable substance which can be bonded to the specimen, and (ii) polyethylene glycol having the molecular weight from 1,500 to 10,000.. .
08/28/14
20140242089
Glycoproteins having lipid mobilising properties and therapeutic applications thereof
A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a zn-α2-glycoprotein, or of a fragment thereof having an apparent molecular mass mr greater than 6.0 kda as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity.
08/28/14
20140238935
Mixed-mode chromatography membranes
Described are composite materials and methods of using them for mixed-mode chromatography. In certain embodiments, the composite material comprises a support member, comprising a plurality of pores extending through the support member; and a multi-functional cross-linked gel.
08/28/14
20140238113
Method for measuring stable hemoglobin a1c using liquid chromatography, and method for simultaneous measurement of stable hemoglobin a1c and abnormal hemoglobin using liquid chromatography
The present invention is a method for measuring stable hemoglobin a1c using liquid chromatography, installing on a flow path of a liquid chromatograph a filter whose surface is treated with a solution containing 1 to 50% by weight of a silicone oil or a solution containing 1 to 50% by weight of a silicone resin, and setting a pressure value generated in a measurement system of the liquid chromatograph to 9.8×103 pa or more and 19.6×105 pa or less.. .
08/21/14
20140230528
Turbulent flow mixing device for use in a chromatography system
A mixing device for use in a chromatography system, the device includes an exterior housing having a first end and a second end and a hydraulic flow connector at the first end of the exterior housing. A cartridge including a chamber is enclosed within the exterior housing.
08/21/14
20140230517
Quality control reagents and methods
The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (ms) and/or liquid chromatography (lc) functionalities..
08/14/14
20140228542
Method for producing peptide fractions and use thereof
The invention relates to a method for producing enriched peptide fractions from protein-containing raw materials, in which protein hydrolysates are separated using chromatography, according to the physiochemical properties thereof, by means of stationary phases with an aqueous solution as an elution agent.. .
08/14/14
20140228539
Separation of acetylated proteins from unacetylated proteins
The invention relates to a process for separating acetylated proteins from unacetylated proteins. In particular, the invention relates to a process of using multimodal chromatography to separate acetylated proteins from unacetylated proteins.
08/14/14
20140227772
Integrated modular unit including an analyte concentrator-microreactor device connected to a cartridge-cassette
The present invention relates to an immunoaffinity device for capturing one or more analytes present at high or low concentrations in simple or complex matrices. The device is designed as an integrated modular unit and connected to capillary electrophoresis or liquid chromatography for the isolation, enrichment, separation and identification of polymeric macromolecules, primarily protein biomarkers.
08/14/14
20140227766
Purification of biological products by constrained cohydration chromatography
Materials and methods for use of constrained cohydration agents in the purification of biological materials such as antibodies, viruses, cells, and cellular organelles in connection with convective chromatography, fluidized bed or co-precipitation applications.. .
08/14/14
20140224740
Preparation of pre-coated rp-rotors and universal chromatorotors, chromatographic separation devices and methods for centrifugal preparative chromatography
Reversed phase solid silica gel sorbent layers which can adhere with appropriate binders to a solid surface were developed. Pre-coated rp-rotors of different thickness were used these pre-coated rp-rotors can be used for centrifugal preparative thin-layer chromatography (cptlc) using any appropriate device for centrifugal chromatography, like chromatotron® or cyclograph.
08/14/14
20140224739
Chromatography columns, systems and methods
The present invention relates to axial flow chromatography columns, methods for separating one or more analytes in a liquid by the use of such columns, and systems employing such columns. The column comprises a first port and a second port, the first port and said second port being at essentially the same level or elevation above the level of the bed space on the chromatography column..
08/14/14
20140224738
Packing of chromatography columns
The invention provides a packing method for high efficiency chromatography columns starting from dry swellable particles, as well as columns packed by the method and the use of the columns in separation of biomolecules. In the packing method, an amount of dry swellable particles sufficient to give a swollen volume in a liquid of about 105-120% of the column chamber volume is transferred to the column, the column is closed and the liquid is provided to the column..
08/14/14
20140224638
Method and apparatus for desolvating flowing liquid
Methods and apparatus for desolvating flowing liquid streams while retaining temporal resolution of dissolved substrates are disclosed. A novel small-scale self-regulating spray dryer preserves temporal resolution while desolvating a liquid chromatography eluent stream and depositing the solute onto an optical surface for infrared spectrographic analysis.
08/14/14
20140224335
Apparatus and methods for fluid processing and flow control
Fluid processing apparatus has a prefabricated branched network of flexible tubing, for conducting process fluid between process elements of the apparatus, and control valves. A tubing support has opposable front and rear plates which define a pattern of support channels between them in which the flexible tubing network lies, so that the support channels limit or prevent expansion of the flexible tubes.


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Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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