|| List of recent Chromatography-related patents
| Device, system and method for in-vivo immunoassay|
In vivo devices, systems and methods for in vivo immunoassay include inserting into a patient's body lumen an in vivo diagnostic device comprising a housing. The housing of the device comprises a chamber, and a chromatography strip for immunoassay of a body lumen substance.
| Immunochromatography detection sensor comprising optical waveguide and a detection method using the same|
The present invention relates to an immunochromatographic detection sensor comprising optical waveguides and a detection method using the same, and more particularly, to an immunochromatographic detection sensor comprising optical waveguides, in which the optical waveguides are provided under the membrane, probe beams transmitted through the optical waveguide maximize the interaction frequency between evanescent wave generated on the surface of the optical waveguide and the colored conjugate in the band formed on the membrane, resulting in the absorbance signal from the colored conjugate being greatly amplified to improve the sample detection sensitivity, and to a detection method using the same.. .
| Pure albumin and its method of preparation and detection|
The subject of the present invention is a pure monomeric bovine serum albumin, a method of producing it characterised by the use column chromatography in resin and a method of identifying it using dynamic light scattering.. .
| Methods for purification of arylsulfatase a|
Methods of producing arylsulfatase a are described herein. The methods can include one or more steps of chromatography.
|Method of extracting lutein/xanthophylls from natural materials and highly purified lutein/xanthophylls obtained from the method thereof|
The present invention provides the new method for extracting lutein from natural materials wherein the said method comprises of modification of natural lutein ester in the natural materials to free lutein and/or low molecular weight lutein ester, extraction of the said natural materials with supercritical fluid at the optimal conditions. The said method yields high amount of crude lutein with high purity due to the mild condition used for extraction.
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product from a feed mixture, which process comprises the steps of: (i) purifying the feed mixture in a first separation step in a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain an intermediate product; and (ii) purifying the intermediate product obtained in (i) in a second separation step using a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, to obtain the pufa product; wherein (a) the first and second separation steps are carried out sequentially on the same chromatography apparatus, the intermediate product being recovered between the first and second separation steps and the process conditions in the chromatography apparatus being adjusted between the first and second separation steps such that the pufa product is separated from different components of the feed mixture in each separation step; or (b) the first and second separation steps are carried out on separate first and second chromatography apparatuses respectively, the intermediate product obtained from the first separation step being introduced into the second chromatography apparatus, and the pufa product being separated from different components of the feed mixture in each separation step.. .
|Isotopic recoding for targeted tandem mass spectrometry|
Aspects of the present disclosure include methods for detecting a low abundance protein and methods for identifying a site of n-glycosylation on a protein. In practicing methods according to certain embodiments, a eukaryotic cell is contacted with an isotopic labeling composition and isotopically labeled n-glycosylated peptides obtained from the eukaryotic cell are assessed by liquid chromatography-tandem mass spectrometry.
|Electrode for nonaqueous electrolyte secondary battery, nonaqueous electrolyte secondary battery, and battery pack|
An electrode for a nonaqueous electrolyte secondary battery of an embodiment has an active material layer containing an active material and a binder containing fluorine, and a current collector bound to the active material layer. When a thermal decomposition start temperature of the binder is t1° c.
|Pump and injector for liquid chromatography|
A combined pump-injector valve utilizing a single piece as the barrel of the pump and as the stator of the valve, thus eliminating any need for connections between a pump and a valve, and therefore the potential for high-pressure leaks or pressure reductions. The combined pump-injector valve permits injection of nanoliter-sized samples into a chromatographic column, which is sealed during loading of the sample and filling of the pump, such that complete analyses can be completed with microliters of mobile phase with nanoliters of a sample..
|Pipe containing a metal casing with a plastics material inlay for use in low and high pressure applications, in particular as an hplc column|
A chromatography column comprises a pipe that contains a tubular metal casing with an inlay and sealing ring. The inlay is configured as a plastics material tube and is pushed or drawn into the metal casing and a sealing ring of plastics material is connected to the inlay at the end.
The present invention provides a chromatographic separation process for recovering a polyunsaturated fatty acid (pufa) product, from a feed mixture, which process comprises introducing the feed mixture to a simulated or actual moving bed chromatography apparatus having a plurality of linked chromatography columns containing, as eluent, an aqueous organic solvent, wherein the apparatus has a plurality of zones comprising at least a first zone and second zone, each zone having an extract stream and a raffinate stream from which liquid can be collected from said plurality of linked chromatography columns, and wherein (a) a raffinate stream containing the pufa product together with more polar components is collected from a column in the first zone and introduced to a nonadjacent column in the second zone, and/or (b) an extract stream containing the pufa product together with less polar components is collected from a column in the second zone and introduced to a nonadjacent column in the first zone, said pufa product being separated from different components of the feed mixture in each zone, and wherein the aqueous organic solvent is other than aqueous alcohol.. .
|Methods of purification of native or mutant forms of diphtheria toxin|
The present invention relates to the use of hydroxyapatite chromatography and multimodal chromatography, for punfication of diphtheria toxin, or a mutant form thereof, from a mixture, for example, a host cell fermentation mixture containing impurities such as host cell proteins and dna. This invention further relates to the integration of such a method into a multi-step procedure with other fractionation methods for purification of diphtheria toxin suitable for in vitro and in vivo applications..
|Chromatography filter paper-based elisa|
A chromatography filter paper-based elisa includes following steps: providing a chromatography filter paper plate provided with a plurality of independent hydrophilic regions defined by at least one hydrophobic region; immobilizing an antigen of a sample onto one of the hydrophilic regions of the chromatography filter paper plate; and detecting the antigen with an elisa process, wherein an antibody used in the elisa process is a monoclonal antibody. The present invention has advantages in lower amount of loaded sample, higher sensitivity and rapid analysis in comparison to conventional elisa..
|Non-invasive detection of fetal genetic traits|
Blood plasma of pregnant women contains fetal and (generally>90%) maternal circulatory extracellular dna. Most of said fetal dna contains 500 base pairs, said maternal dna having a greater size.
|Device for controlling a piston pump unit for liquid chromatography|
A control device of a piston pump unit comprising at least two piston-cylinder units that operate in a phase-shifted manner for the purpose of liquid chromatography and to a piston pump unit is described. The control device corrects fluctuations of the system pressure while switching from one piston cylinder unit to the respective other piston cylinder unit.
|Vacuum ultraviolet absorption spectroscopy system and method|
An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
|Rotary shear valve with a two-pin drive shaft for liquid chromatography applications|
A rotary shear valve assembly for liquid chromatography applications comprises a rotor assembly having a rotor and a drive shaft with a head portion. The rotor has a substantially planar surface with one or more rotor grooves and a pair of holes.
|Chromatography system with led-based light source|
A detector system having a single emitter body. The emitter body has a plurality of light emitting diodes (leds) for emitting a plurality of wavelengths.
|Collection system for purification flowstreams|
A collection system for collecting samples from a flowstream (5) exiting a supercritical fluid chromatography system is provided. The collection system comprises: (i) a first back pressure regulator (10) on the flowstream as it exits the chromatography system, (ii) a gas-liquid separator (30) having a tapered and angled dripper (65), which introduces the flow into the separator at an angle tangential to the separator wall; and (iii) one or more fraction collectors (15), wherein the fraction collector is at a reduced pressure collection point, between 100 bar and atmospheric pressure.
|Efficient chiller for a supercritical fluid chromatography pump|
Methods and systems for pumping compressible fluids in high pressure applications such as high-pressure liquid chromatography (hplc) or supercritical fluid chromatography (sfc) applications are disclosed. An improved cooling device for a pump head for use in a supercritical fluid chromatography (sfc) system is described.
|Purification of fusion proteins|
The invention relates generally to methods for purifying a fc-fusion protein produced in a eukaryotic expression system. More specifically, the invention provides a robust and scalable downstream purification process suitable for use in manufacturing tnfr:fc for human administration which comprises an optimized protein a affinity chromatography step and two ion exchange chromatography steps both of which are operated in the bind-and-elute mode..
|Single unit chromatography antibody purification|
The present invention relates to a method for the purification of antibodies from a protein mixture produced in a bioreactor, at least comprising the steps of intermediate purification and polishing, wherein the intermediate and polishing step comprises in-line anion exchange chromatography (aex) treatment and mixed mode chromatography (mimo) treatment in flow through mode. The present invention further relates to a single operational unit comprising both an anion exchange chromatography part and a mixed mode chromatography part, which are serially connected, wherein the unit comprises an inlet at the upstream end of the anion exchange chromatography part and an outlet at the downstream end of the mixed mode chromatography part and wherein the unit also comprises an inlet between the anion exchange chromatography part and the mixed mode chromatography part..
|Low ph protein purification process|
The invention relates to a process for recovering and purifying bile salt-stimulated lipase (bssl) in a solution which contains impurities, said process comprising the steps: (i) applying bssl to a hydrophobic interaction chromatography (hic) resin; (ii) removing impurities by washing said hic resin with a wash composition having a ph in the range from 4 to 5; and (iii) recovering bssl from said hic resin.. .
|Uncoated housing and method for manufacturing same|
The present invention is an uncoated housing in which a molded product formed from a thermoplastic resin composition (d) containing 20-60% by mass of an acetone insoluble resin component (a), which contains a rubber component (a) with an average particle size of 0.05-0.3 μm and has a coefficient of linear expansion of 11×10−5-20.5×10−5, 40-80% by mass of an acetone soluble resin component (b) (here, (a)+(b)=100% by mass), and a colorant (c), with (1) the acetone soluble resin component (b) containing 6.0-45% by mass of an unsaturated nitrile monomer derived component and (2) 2-20% by mass of a component with a molecular weight of 70,000 or less by gel permeation chromatography (gpc) measurements being contained in the acetone soluble resin component (b). On the basis of jis k7105, the l* value for this uncoated housing is 13 or less, the luster 60-120%, and the haze value 30-90%..
|Graft copolymer for cation-exchange chromatography|
The invention relates to chromatographic separating materials having improved binding capacity for biological constituents in cell culture supernatants, or animal or human body fluids, in particular for monoclonal antibodies. The present invention likewise relates to the preparation of separating materials of this type, and to the use thereof, in particular for the removal of charged biopolymers from corresponding liquids..
|Sonication for improved particle size distribution of core-shell particles|
In one or more embodiments, a porous composite particulate material includes a plurality of composite particles including an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles. The shell particles are adhered to the core particle by a polymeric material.
|Chromatography column and method for isolating nucleic acid|
The present invention provides a chromatography column and a method for isolating nucleic acid molecules. In one embodiment, the present invention provides a double-layer column of a first anion exchange membrane and a second serially coupled silica membrane.
|Protein purification using hcic and ion exchange chromatography|
The present invention provides methods for purifying proteins. In particular, the methods employ a two-step non-affinity chromatography process without the use of an in-process tangential flow filtration step..
|Viral purification methods|
The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filtration and column chromatography.
|Method for separating peptides and proteins|
Embodiments of the present invention are directed to articles of manufacture, devices, methods and apparatus for performing liquid chromatography featuring a chromatographic sorbent having one or more pentafluorophenyl groups, wherein said one or more pentafluorophenyl groups are a bonded phase on a sorbent selected from the group comprising silica, organic polymers or hybrid organic silane material and said pentafluorophenyl groups are in a mono-, bi-, and tridentate forms.. .
|Separation of glycans by mixed-mode liquid chromatography|
An exemplary multimodal chromatographic medium of the invention includes one or more strong anion exchange, weak anion exchange, strong cation exchange and/or weak cation exchange binding sites in combination with one or more reverse phase and/or hydrophilic interaction chromatography binding site. In an exemplary embodiment, the sites interact with one or more glycans in a mixture of glycans in a manner that allows separation of glycans in the mixture and analysis of the glycan mixture.
|Capture of pathogenic and non-pathogenic biopolymers and bioparticles|
B) providing a support matrix modified to have, at predetermined conditions, such a net negative surface charge and net surface hydrophobicity in relation to the net negative surface charge and the net surface hydrophobicity of the selected biopolymer or bioparticle that the modified support matrix is capable of selective interaction and capture of the biopolymer or bioparticle through a resulting net hydrophobic interaction being the actual hydrophobic interaction minus the actual electrostatic repulsion. The use of such a capturing agent as a therapeutically active substance, as well as in chromatography and diagnosis are also disclosed..
|Fluid sample holders with piston valve|
Disclosed is a fluid sample holder 20 for delivering or receiving a fluid sample to or from fluid processing equipment such as a chromatography column 5 (fig. 1).
|Fluid sample holders with piston valve|
Disclosed is a fluid sample holder 20 for delivering or receiving a fluid sample to or from fluid processing equipment such as a chromatography column 5 (fig. 1).
|Microfluidic device with dried blood spots (dbs) card interface|
An apparatus for use in a chromatography system includes a first microfluidic substrate having a first fluidic channel. One end of the first fluidic channel terminates at a first fluidic port on a first side of the first microfluidic substrate and an opposite end of the first fluidic channel terminates at a second fluidic port on a second side of the first microfluidic substrate.
|Thin layer chromatography plates and related methods of manufacture including priming prior to infiltration with stationary phase and/or precursor thereof|
In an embodiment, a method for manufacturing a thin layer chromatography (“tlc”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), priming the elongated nanostructures with one or more adhesion priming layers, and at least partially coating the elongated nanostructures with a coating.
|Chromatography column assembly|
Described is a chromatography column assembly that includes a permanently deformable outer tube, an intermediate tube, an inner tube and a sorbent bed disposed within the inner tube. The sorbent bed may be in the form of packed chromatographic particles or a porous monolithic structure.
|Control system and method for flash separation|
A chromatography system may include: a first solvent supply operatively connected to a chromatography column; a second solvent supply operatively connected to the chromatography column; a controller operatively connected to the first and second solvent supplies for delivering a flow of a solvent system to an inlet for the chromatography column in accord with a predetermined solvent gradient, wherein the flow of the solvent system through the chromatography column will separate components from a sample composition; and a collection apparatus operatively connected to an outlet from the chromatography column for collecting designated portions of the solvent system flow exiting the column. The controller may determine a target sample mass as a function of chromatography column parameters..
There is provided a capillary column comprising a flat cross section and a desired theoretical plate number and having both high resolution and high sample load capacity. The capillary column 1 comprising a stationary phase on an inactivated inner surface, which is used in gas chromatography, comprises a narrow part 3 formed in a central part of a cross section of internal space and a bulge part 4 formed on each of both sides of the narrow part 3..
|Method for purifying pegylated erythropoietin|
Herein is reported a method for the purification of a protein comprising erythropoietin and a single poly (ethylene glycol) residue from reaction by-products or not reacted starting material by a cation exchange chromatography method. It has been found that by employing a cation exchange sp sephacryl™ s 500 hr chromatography material conditioned to a conductivity of 21 ms/cm and a linear gradient elution a fusion protein of erythropoietin and a single poly (ethylene glycol) residue can be obtained in a single step with high purity and yield..
|Preparing chloride-free polyethyleneimines|
Polyalkyleneimines obtained by such methods and formulations thereof likewise form part of the subject matter of the invention, especially those having a low proportion of chloride-containing compounds. Such polyalkyleneimines have uses in the field of medical technology, printing media, wastewater treatment, surface treatment, cosmetics, laundry detergents, biotechnology, packaging, electronics, paper, building construction chemistry, textiles, chromatography, ion exchangers, oil industry, ceramics, glass, membrane technology, catalysts, electroplating, biocides or wood protection.
|Method for measuring hemoglobins|
The present invention aims to provide a method of measuring hemoglobins which can measure hemoglobins in a short time at high accuracy. The present invention also aims to provide a method of measuring hemoglobin a1c, a method of simultaneously measuring hemoglobin a1c and hemoglobin f, a method of simultaneously measuring hemoglobin a1c and hemoglobin a2, and a method of simultaneously measuring hemoglobin a1c and abnormal hemoglobins, each utilizing the above-mentioned method of measuring hemoglobins by liquid chromatography.
|Isoform entriched antibody preparation and method for obtaining it|
Herein is reported a method for producing an antibody preparation comprising the steps of a) applying a buffered solution comprising different isoforms of an antibody to a cation exchange chromatography material, b) applying a first solution with a first conductivity to the cation exchange chromatography material, whereby the antibody isoforms remain bound to the cation exchange chromatography material, and c) applying a second solution with a second conductivity to the cation exchange chromatography material and thereby obtaining the antibody preparation, whereby the conductivity of the second solution exceeds the conductivity of the first solution by not more than 10%.. .
|Rapid and accurate analysis of protein sialylation|
The invention relates to methods and kits for the analysis of the sialylation of gluco-proteins. The samples of gluco-protein are incubated separately under three conditions: with beta-galactosidase, with beta-galactosidase+alpha-sialidase, and without an enzyme.
|Immobilized enzymatic reactor|
An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide.
|Use of aptamers in liquid chromatography and liquid chromatography - mass spectrometry|
The present disclosure relates to the use of aptamers in solid phase extraction, chromatography and chromatography-mass spectrometry systems. More specifically, the present disclosure relates to the use of aptamers in spe and chromatography systems to selectively retain, extract and/or pre-concentrate target molecule(s) having a specific affinity for the particular aptamer(s).
|Fluorine-containing polymer, purification method, and radiation-sensitive resin composition|
A fluorine-containing polymer for use in a radiation-sensitive resin composition is used for forming a photoresist film in a process of forming a resist pattern, including a liquid immersion lithographic process in which radiation is emitted through a liquid having a refractive index larger than the refractive index of air at a wavelength of 193 nm, and being present between a lens and the photoresist film. The fluorine-containing polymer has a weight average molecular weight determined by gel permeation chromatography in the range from 1,000 to 50,000 and a receding contact angle with water and the photoresist film formed therefrom is 70° or more..
|Liquid chromatography conduit assemblies having high pressure seals|
Described is a tubing assembly which includes a permanently deformable outer tube, an intermediate tube and an inner tube. A radial seal is provided by a uniform radial crimp having a non-zero longitudinal length at a longitudinal location on the tubing assembly.
|Chromatography apparatus having diffusion bonded coupler|
Described is a chromatography a chromatography apparatus that includes a microfluidic substrate, a coupler and a sealing fitting. The microfluidic substrate can include one or more chromatography columns, such as analytical columns or trap columns, and an inlet in communication with the one or more chromatography columns.
|Downhole determination of asphaltene content|
A system and method for determining the asphaltene content of a downhole oil sample are provided. In one example, the method includes obtaining a hydrocarbon sample from a hydrocarbon formation of a reservoir at a given depth using a downhole tool.
|System and method for rapid analysis of polymer additives|
The subject technology is directed to a co2-based chromatography system and method for rapid determination of the levels and/or the presence or absence of polymer additives (pas) leachable or extractable from packing materials or implantable medical devices.. .
|Gas chromatography chip and multi-layered gas chromatography chip assembly thereof|
Disclosed is a gas chromatography chip including: a substrate having an upper substrate and a lower substrate; a gas supply connecting part formed on one plane of one surface of the substrate or on one plane of an opposite surface of the substrate; a gas discharge connecting part formed another plane of the one surface of the substrate or on another plane of the opposite surface of the substrate; a micro channel continuously extending from the gas supply connecting part to the gas discharge connecting part to form a micro channel part and having a circular cross-section; at least two position alignment markers formed on one surface or an opposite surface of the opposite surfaces of the substrate; and a heat transfer part and a temperature control unit for controlling a temperature of the substrate.. .
|Multi-dimensional gas chromatography chip with modulator|
Disclosed is a multi-dimensional gas chromatography chip with a modulator. The multi-dimensional gas chromatography chip includes a chip body including first to third substrates; first micro channel pattern parts including first micro channels; second micro channel pattern parts including second micro channels; a gas inlet to supply a mobile phase; a gas outlet to discharge the mobile phase; position alignment markers formed on one surface of the first substrate, both surfaces of the second substrates and one surface of the third substrate; a first stationary phase spin-coated between the first and second substrates and a second stationary phase spin-coated between the second and third substrates; and a modulator provided in a region serving as an inlet side of the first micro channel pattern parts as well as an outlet side of the second micro channel pattern parts..
|System for quantitative chemical analysis of samples, in particular in the medical field, with calibration of the instrumental response, and the corresponding method|
Analysis system for the quantitative chemical analysis of samples includes a detection equipment to detect the quantity of target analytes in the samples to be analyzed, which includes a chromatography system, an ion source and a mass spectrometer; a data processing system to process quantitative data of the target analytes in the samples analyzed, as detected by the detection equipment; and an innovative database containing corrective and control data and coefficients to calibrate and correct the instrumental response of the detection equipment, wherein the corrective and control data and coefficients are determined and acquired by the database before the actual analysis of the samples, the sample being prepared with a universal dilution solution to minimize the corresponding matrix effect, the data processing system determining the quantitative data of the target analytes by processing the quantitative data taking account of the corrective and control data and coefficients contained in the database.. .
|Double-sided adhesive tape and method for producing the same|
In a double-sided adhesive tape in which acrylic-based adhesive layers are formed on respective sides of an electron beam cross-linked polyethylene foam substrate, the acrylic-based adhesive layers are formed from a cured resin composition formed by irradiating a solvent-free photopolymerizable monomer composition containing an acrylic-based monomer and a photopolymerization initiator with ultraviolet rays to photo-polymerize the acrylic-based monomer. The cured resin composition contains an adhesion-imparting polymer having a weight average molecular weight of 2,000 to 10,000, an acrylic-based polymer a obtained by photopolymerization in the absence of a cross-linking agent and having a weight average molecular weight of 700,000 to 3,000,000, and an acrylic-based polymer b obtained by photopolymerization in the absence of a cross-linking agent and having a weight average molecular weight of 350,000 to 650,000.
|Coloring composition, colored pattern, color filter and method of producing the same, pattern forming method, solid-state imaging device, and image display device|
In order to achieve the above objects, the present invention provides a coloring composition containing a resin (a) having a dye structure, in which in a peak area of the total molecular weight distribution of the resin (a) measured by gel permeation chromatography, a proportion of a peak area of a component having a molecular weight of 20,000 or more is 10% or less.. .
|Purification of non-human antibodies using kosmotropic salt enhanced protein a affinity chromatography|
The present invention is directed to methods for purifying a non-human antibody, or antigen binding portion thereof, exhibiting weak binding strength and low binding capacity for protein a chromatography media. In one aspect, a kosmotropic salt solution is employed to promote the hydrophobic interaction between the non-human antibody, or antigen binding portion thereof, and the protein a ligand, thereby enhancing the binding of the non-human antibody, or antigen binding portion thereof, to the protein a chromatography media.
|Coloring composition, colored cured film, color filter, manufacturing method of the same, and sold state imaging device|
A coloring composition which suppresses color loss of the colored pattern to be formed, and may form a colored pattern which has excellent developability and heat resistance is provided. A colored cured film which suppresses color loss of the colored pattern to be formed, and may form a colored pattern which has excellent developability and heat resistance, a color filter which is provided with the colored pattern, and a manufacturing method thereof are provided.
|System and method for film-based chromatographic separation|
A film based chromatography system for capturing and releasing a material from a fluid. In one embodiment, the system includes a housing containing a spiral wound film element.
|Non-seizing tapers for use in purged connections of capillary tubing used in gas chromatography|
A non-seizing taper used for purged capillary tubing connections in gas chromatography that stops capillary tubing at a predictable position within the taper during installation and maintains space for gas to flow past the capillary tubing. The disclosed taper is an improved component of commonly used purged devices such as inlet liners and purged unions.
|Column manager with a multi-zone thermal system for use in liquid chromatography|
A thermal system for use in a column manager of a liquid chromatography system comprises a plurality of spatially separated individually controlled thermoelectric chips. A column module houses a plurality of thermally conductive troughs.
|Method for preparing tetrazole methanesulfonic acid salts, and novel compound used in same|
A method for preparing tetrazole methanesulfonic acid salts includes an acylation reaction using a novel 4-iodine-4h-chromene-2-carbothionic acid s-benzothiazole-2-yl ester. The method is advantageous that it can shorten a reaction time and improve safety as compared to conventional methods, and can prepare high-purity tetrazole methanesulfonic acid salts at a high yield rate without using a column chromatography method..
|Lc-ms separation and detection of vitamin d metabolites|
Systems, kits, and methods for quantitation of metabolites of vitamin d by liquid chromatography-mass spectrometry (lc-ms). The systems, kits, and methods described herein stabilize and/or promote the formation of the protonated molecular ion ([m+h]+) for the vitamin d metabolites in the ionization source (e.g., electrospray ionization (“esi”)).
|Method for detecting single nucleotide polymorphisms|
An object of the present invention is to provide a method for rapidly and simply detecting single nucleotide polymorphisms. The present invention is a method for detecting single nucleotide polymorphisms, comprising analyzing wild-type and mutant-type products amplified by an as-pcr method using ion-exchange chromatography..
|Connector unit and connecting system for connecting capillaries, in particular for high-performance liquid chromatography|
The invention relates to a connector unit for connecting capillaries, in particular for high-performance liquid chromatography, wherein a sealing element sealing the capillary protrudes at least partially into the interior of the capillary, while a portion of the sealing element that protrudes axially from the capillary can be subjected to a compressive force that is introduced via the capillary to obtain an axial or radial plastic and/or elastic deformation.. .
|Light-emitting element, light-emitting device, electronic device, and lighting device|
To provide a light-emitting element with high emission efficiency. In a light-emitting element including an organic compound between a pair of electrodes, the molecular weight x of the organic compound is 450 or more and 1500 or less, and the absorption edge of the organic compound is at 380 nm or more.
|Flash chromatography cartridge|
A low pressure liquid chromatographic cartridge has a tubular polymer container that receives a chromatographic packing material. The container has an outlet port located at its downstream end and container threads formed on its upstream end.
|(meth)allylsilane compound, silane coupling agent therefor, and functional material using same|
A (meth)allylsilane compound chemically bonded to various alcohol derivatives including polyol derivatives such as saccharides, is raw material used to cause a substrate to express functionalities such as a defogging property and separation characteristics for column chromatography, can be easily prepared, is easily purified, and is stable and easy to handle, and a functional material in which those functionalities are expressed, while silyl group-containing groups are conveniently carried at a high density on the surface of the substrate, by using the (meth)allylsilane compound as a silane coupling agent for silane-coupling to the substrate. The (meth)allylsilane compound includes a (meth)allylsilyl group-containing alkyl group or a (meth)allylsilylalkyl group-containing aralkyl group that is bonded to an alcohol derivative.
|Method for separation of monomeric polypeptides from aggregated polypeptides|
The present invention relates to methods for obtaining a polypeptide in a monomeric form, the method comprising a) providing a solution containing the polypeptide in monomeric form and in aggregated form, wherein the ratio of monomeric to aggregated form is 4:1 or less, as determined by size exclusion chromatography, b) performing mixed-mode chromatography in bind-and-elute mode, or hydrophobic interaction chromatography in flow-through mode, or a size-exclusion chromatography, and c) performing a weak cation exchange chromatography in bind-and-elute mode or flow-through mode, and thereby obtaining the polypeptide in monomeric form.. .
|Extract of asplenium nidus l.|
An extract of asplenium nidus l. Includes pyropheophorbide a methyl ester (c34h36n4o3), pheophorbide a methyl ester (c35h36n4o5), 1-linleoyl-3-linolenoyl-glycerol (c39h66o5), 1-linleoyl-2,3-dipalmitoyl-rac-glycerol (c53h98o6) and 1,3-dipalmitoyl-sn-glycerol (c35h68o5).