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This page is updated frequently with new Chromatography-related patent applications. Subscribe to the Chromatography RSS feed to automatically get the update: related Chromatography RSS feeds. RSS updates for this page: Chromatography RSS RSS


Date/App# patent app List of recent Chromatography-related patents
04/30/15
20150119605
 Process for the preparation of pillar[5]quinone patent thumbnailnew patent Process for the preparation of pillar[5]quinone
The present invention relates to a process for the preparation of pillar[5]quinone and further relates to an easy-to-operate and chromatography-free process for the preparation of crystalline pillar [5] quinone by the oxone/iodobenzene-mediated oxidative de-aromatization of readily available 1,4-dimethoxypillar[5] arenes in good. .
Council Of Scientific & Industrial Research
04/30/15
20150118675
 Immunochromatography detection method patent thumbnailnew patent Immunochromatography detection method
The present invention provides an immunochromatography detection method capable of suppressing non-specific reactions. The present invention relates to an immunochromatography detection method including: a step of adding an analyte dilution solution containing an analyte to a chromatography medium; a step of recognizing a detection target by a labeling substance modified with gold nanoparticles, which is dry-retained at a labeling substance retaining part; a step of developing a composite of the labeling substance and the detection target as a mobile phase; and a step of detecting the detection target in the developed mobile phase at a judgment part, wherein the labeling substance is protected with a polyalkylene glycol having one or more mercapto groups and/or a derivative thereof and then dry-retained together with arginine and casein at the labeling substance retaining part..
Tanaka Kikinzoku Kogyo K.k.
04/30/15
20150115151
 Ion mobility spectrometer patent thumbnailnew patent Ion mobility spectrometer
A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. The improvement accelerates the ion mobility analysis and improves charge throughput and dynamic range of the ims.
Leco Corporation
04/23/15
20150112609
 Plus-fraction corrections for heavy hydrocarbon liquids patent thumbnailPlus-fraction corrections for heavy hydrocarbon liquids
A method of determining the plus-fraction correction for a heavy oil sample including analyzing the heavy oil sample using gas chromatography, selecting an elution ratio based on the percentage of plus-fraction elution, applying the elution ratio to provide a maximum carbon number and a plus-fraction correction to compensate for the non-elution of the plus-fraction. An elution ratio as a function of the percentage of c60+ elution is provided.
Weatherford Canada Partnership
04/23/15
20150111844
 Polyphenol composition patent thumbnailPolyphenol composition
A polyphenol composition derived from camellia sinensis and contains flavonol aglycones and flavonol glycosides, in a weight ratio [(b)/(a)] of the following total contents (b) to (a) is from 0.01 to 18, wherein (a) total content of the flavonol aglycones contained in solids of the polyphenol composition after hydrolysis as measured by high-performance liquid chromatography, and (b) total content of the polyphenols contained in solids of the polyphenol composition as measured by the ferrous tartrate method.. .
Kao Corporation
04/23/15
20150111307
 Organic colored microparticles, diagnostic reagent kit containing the same, and in vitro diagnosis method patent thumbnailOrganic colored microparticles, diagnostic reagent kit containing the same, and in vitro diagnosis method
Provided are an immunochromatography kit that is highly sensitive and capable of multicoloration, and organic colored microparticles that are ideal as an element of the immunochromatography kit. Organic colored microparticles having an average grain size between 10 and 1,000 nm and a color intensity between 1.0 and 5.0 are prepared using cellulose as the starting material.
Asahi Kasei Fibers Corporation
04/23/15
20150111305
 Multielectrode electrolytic device and method patent thumbnailMultielectrode electrolytic device and method
An electrolytic device comprising: a central sample flow channel, first and second regenerant flow channels, first and second charged barriers disposed between said sample flow channel and first and second regenerant flow channels, and pairs of oppositely charged, spaced electrodes disposed in the regenerant flow channels. Also, electrolytic devices with a different electrode configuration are described.
Dionex Corporation
04/23/15
20150111025
 Dispersion liquid of carbon nanotube-containing composition and conductive molded body patent thumbnailDispersion liquid of carbon nanotube-containing composition and conductive molded body
The present invention relates to a dispersion liquid of a carbon nanotube-containing composition which contains a carbon nanotube-containing composition, a dispersant with a weight-average molecular weight of 5,000 to 60,000 as determined by gel permeation chromatography, and an aqueous solvent. The present invention provides a dispersion liquid of a carbon nanotube-containing composition which shows high dispersibility on a base while maintaining high dispersibility for the carbon nanotube-containing composition..
Toray Industries, Inc.
04/23/15
20150111023
 In-situ heated deposition of parylene to enhance pore penetration into silicone patent thumbnailIn-situ heated deposition of parylene to enhance pore penetration into silicone
Coating porous material, such as pdms, with parylene n, c, d, and af-4 by vapor deposition polymerization is described in which a temperature of the porous material's surface being coated is heated to between 60° c. And 120° c., or 80° c.
California Institute Of Technology
04/23/15
20150110862
 Sweet gum fruit extract as a therapeutic agent patent thumbnailSweet gum fruit extract as a therapeutic agent
Sweet gum (liquidambar styraciflua l., family hamamelidaceae) fruit extract was discovered to possess potent activities against multiple targets of the pi3k (phosphatidylinositide 3-kinase) pathway, especially the pi3k/akt and mtor pathways. At a very low concentration of 1.85 μg/ml (ic50), sweet gun extract showed the ability of simultaneously blocking the pathways of pi3k/akt (upstream), mtor (mammalian target of rapamycin) (downstream), as well as its downstream protein products s6k and s6.
Board Of Regents
04/23/15
20150110803

Low acidic species compositions and methods for producing and using the same using displacement chromatography


The present invention relates to low acidic species (ar) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods for producing such low ar compositions using displacement chromatography. Methods for using such compositions to treat a disorder, e.g., a disorder in which tnfα is detrimental, are also provided..
Abbvie, Inc.
04/23/15
20150107334

Continuous measurement chromatography and continuous stochastic perturbation chromatography


A method and system for continuous measurement chromatograph involves stochastically modulating a system variable. The sample can be introduced into a chromatography column.
Massachusetts Institute Of Technology
04/23/15
20150107332

Microfluidic contaminant trap for trapping contaminants in gas chromatography


Microfluidic contaminant traps of certain representative embodiments illustratively comprise: an inlet configured to connect directly or indirectly to a sample inlet of a gas chromatography (gc) system; an outlet configured to connect directly to an inlet of a gc column or indirectly to the gc column via another fluidic component; an interlayer comprising a channel; an upper layer disposed over and bonded to the interlayer; and a coating disposed over the channel. The coating reduces interactions of analytes from a sample provided at the inlet of the microfluidic contaminant trap with the microfluidic contaminant trap..
Agilent Technologies, Inc.
04/23/15
20150107331

Integrated hydrocarbon analysis


Petroleum or other hydrocarbon samples can be analyzed in parallel by 1) gc-field ionization time of flight mass spectrometer (gc-fi-tof ms) and 2) two dimensional gas chromatography (2d-gc) equipped with a flame ionization detector (fid). The combined techniques allow for improved quantitative characterization of the compounds within a hydrocarbon sample.
Exxonmobil Research And Engineering Company
04/16/15
20150106029

Method of characterizing crude oil by high pressure liquid chromatography


A system and a method are provided for calculating the cetane number, octane number, pour point, cloud point and aniline point of a crude oil fractions from the density and high pressure liquid chromatography (hplc) of a sample of the crude oil.. .
04/16/15
20150104849

Methods of purifying recombinant adamts13 and other proteins and compositions thereof


Provided herein are methods for purifying recombinant a disintegrin-like and metallopeptidase with thrombospondin type 1 motif 13 (adamts13) protein from a sample. The method comprises enriching for adamts13 protein by chromatographically contacting the sample with hydroxyapatite under conditions that allow adamts13 protein to appear in the eluate or supernatant from the hydroxylapatite.
Baxter International Inc.
04/16/15
20150104833

Novel protein having b-glucosidase activity and uses thereof


By combination of hydrophobic chromatography and strongly basic anion-exchange chromatography, a novel, highly hydrophobic β-glucosidase was successfully identified from acremonium cellulolyticus. Further, a gene corresponding to the identified β-glucosidase was isolated.
Meiji Seika Pharma Co., Ltd.
04/16/15
20150101419

Phase detection in multi-phase fluids


The present disclosure relates to phase detection in multi-phase fluids where two fluid phases can be present in the fluid. Phase detection apparatus and methods are disclosed for determining the phase(s) (e.g., supercritical, liquid, and/or gas) of a fluid in a multi-phase fluid system, such as carbon dioxide based separation and chromatography system..
Waters Technologies Corporation
04/09/15
20150099308

Determination of polycyclic aromatic hydrocarbons in water using nanoporous material prepared from waste avian egg shell


Nanoporous polymorphic crystals of caco3 were used as sorbent and were applied in the dispersive micro-solid-phase extraction of selected polycyclic aromatic hydrocarbons as target analytes. After separation of the analytes on gas chromatography, they were successfully quantified with external calibration using flame ionization detection.
King Fahd University Of Petroleum And Minerals
04/09/15
20150099293

Buoyant protein harvesting device


A buoyant device containing chromatography media performs the function of protein harvesting replacing the steps of cell separation and volume reduction; the device can be loaded into columns for further purification.. .
Therapeutic Proteins International, Llc
04/09/15
20150096349

Optimize analyte dynamic range in gas chromatography


A non-specific gas analyzer with a wide dynamic range of concentration is used to assess the gas sample for total load of volatile organic constituents, and then control either a dilution with neutral gas or the quantity of sample aspirated in order to consistently deliver an appropriate total load of volatile analyte to a high-sensitivity analyzer. Such high-sensitivity analyzers may be gas chromatography combined with mass spectrometry or related mass spectrometry configurations, such as selected ion flow tube mass spectrometry, gas chromatography combined with ion mobility spectrometry, or related ion mobility configurations such as differential mobility spectrometry..
Pen Inc.
04/02/15
20150094443

Polythiol composition, polymerizable composition for optical material and use thereof


A polythiol composition according to the present invention includes a polythiol compound (a) having three or more mercapto groups and a nitrogen-containing compound (b) in which one of a mercapto group of the polythiol compound (a) is replaced with a group represented by the following formula (a) and other one of a mercapto group of the polythiol compound (a) is replaced with a hydroxyl group, in which the peak area of the nitrogen-containing compound (b) is equal to or less than 3.0 with respect to the peak area of 100 of the polythiol compound (a) in a high performance liquid chromatography measurement.. .
Mitsui Chemicals, Inc.
04/02/15
20150093800

Method for chromatography reuse


The present invention provides methods for cleaning or regenerating a chromatography materiel for reuse. The methods of the invention can be used for cleaning or regenerating chromatography columns for reuse in the large-scale manufacture of multiple polypeptide products..
Genentech, Inc.
04/02/15
20150093531

Container for precision member and preparing the same


A container for precision members is prepared from a polycarbonate resin, wherein a polycarbonate resin solution prepared by immersing the polycarbonate resin in water and leaving the solution has chloride ions (cl−), fluoride ions (f−) and sulfate ions (so42-) in a concentration of about 2 ppb or less, independently of each other, as detected by ion chromatography (ic). The container for precision members is capable of preserving and transporting the precision members predisposed to damage by minor amounts of impurities or contaminants without damage..
Samsung Sdi Co., Ltd.
04/02/15
20150093322

Method for purifying multi-walled carbon nanotubes


A method comprising adding a multi-walled carbon nanotube synthesized by the vapor phase process to a nitric acid aqueous solution of not lower than 0.2 mol/l so as to dissolve a catalyst metal present in the multi-walled carbon nanotube, performing solid-liquid separation to isolate solid matter, and subjecting the isolated solid matter to heat treatment at a temperature higher than 150° c. Gives a purified multi-walled carbon nanotube in which the amount of a metallic element left in the multi-walled carbon nanotube originating the catalyst metal is not smaller than 1000 ppm and not larger than 8000 ppm determined by icp optical emission spectrometry and the amount of an anion left in the multi-walled carbon nanotube originating in the acid is smaller than 20 ppm determined by ion chromatography analysis..
Showa Denko K.k.
04/02/15
20150090014

Detector for liquid chromatography


A detector for liquid chromatography has light sources that generate light in an ultraviolet region and in a near-infrared region; a flow cell, through which sample liquid flows; an optical system to let light generated from the light sources become incident on the flow cell concurrently; a detection element that detects light in the ultraviolet region that passes through the flow cell; a detection element that detects light in the near-infrared region that passes through the flow cell; and an arithmetic operation part that performs arithmetic operation of a first signal value obtained from the detection element and of a second signal value obtained from the detection element. The arithmetic operation part combines the first signal value and the second signal value to calculate a signal value with a reduced baseline fluctuation resulting from a mobile phase during a gradient analysis..
Hitachi High-technologies Corporation
04/02/15
20150089998

Manifolds and methods of using them to control fluid flows


Certain embodiments described herein are directed to devices that can be used to control fluid flow through one or more detectors. In some configurations, the device can be configured as a manifold that can receive a positive pressure to decouple the flow of fluid through a chromatography column from fluid flow through a detector.
Perkinelmer Health Sciences, Inc.
03/26/15
20150087816

Doped materials for reverse phase chromatography


A material for reverse phase chromatography comprises surface modifying apolar and charged groups bound to a solid support, said charged groups being present in amounts of about 0.25 to about 22% of the surface modifying groups, or in amounts of about 0.01 μmol/m2 to 0.8 μmol/m2 referred to the surface of the solid support for a material with a total amount of surface modifying groups of 3.6 μmol/m2. Such material and suitable purification conditions for active pharmaceutical ingredients (apis) like peptides can be evaluated by (a) determining the isoelectric point (pi) of the api of interest, (b) choosing a ph in a range where the solid phase material is stable, (c) determining the difference pi-ph and (d) if the difference pi-ph is positive, choosing an anion exchange (aiex) material, or if the difference pi-ph is negative, choosing an cation exchange (ciex) material..
Zeochem Ag
03/26/15
20150087073

Methods for quantifying polypeptides using mass spectrometry


A method for identifying a polypeptide a specimen can include (i) treating a specimen suspected of comprising an insulin with a base; (ii) extracting a first fraction of the treated specimen by solid phase extraction using a mixed mode or polymeric reversed-phase media and a first solvent comprising an acid; (iii) separating a component of the first fraction by liquid chromatography using a chromatographic surface including a hydrophobic surface group and one or more ionizable modifiers, and a second solvent comprising an acid; and (iv) analyzing the component of the first fraction by mass spectroscopy, thereby identifying the polypeptide, if present, using a signal corresponding to a sequence fragment ion from the polypeptide. The signal can correspond to an intact multiply charged precursor fragment selected in a first quadrupole and its corresponding sequence fragment ion selected in a final quadrupole..
Waters Technologies Corporation
03/26/15
20150086974

Immunochromatographic test strip and detection method using immunochromatography for detecting target in red blood cell-containing sample


A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions..
Sekisui Medical Co., Ltd.
03/26/15
20150085217

Retardation film, process for producing polarizer, and liquid-crystal display device


The purpose of the present invention is to provide a retardation film which includes cellulose acetate having a low degree of acyl substitution and, despite this, swells very little when immersed in a saponifying solution and which has satisfactory adhesion to polarizing elements. This retardation film comprises: a cellulose ester which has a total degree of substitution with acyl groups of 2.0-2.55 and in which when log [mw(a)] obtained through analyses by gel permeation chromatography (gpc), low angle laser light scattering (lalls), and viscosity measurement, is plotted as abscissa and log [iv(a)], obtained through the analyses is plotted as ordinate, the plot has a slope of 0.65-0.85; and a glass-transition-temperature lowering agent having an sp value of 9.0-11.0.
Konica Minolta, Inc.
03/19/15
20150080558

Chromatography matrices including novel staphylococcus aureus protein a based ligands


The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, staphylococcus aureus protein a (spa), as well as methods of using the same.. .
Emd Millipore Corporation
03/19/15
20150080554

Affinity chromatography matrix


The invention discloses an immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal protein a (e, d, a, b, c) or protein z or a functional variant thereof, wherein in at least one of the one or more mutated monomers, the asparagine or histidine at the position corresponding to h18 of the b domain of protein a or of protein z has been deleted or substituted with a first amino acid residue which is not proline or asparagine and wherein, if the amino acid residue at position 57 is proline and the amino acid residue at position 28 is asparagine, then the amino acid residue at the position corresponding to h18 of the b domain of protein a or of protein z is not serine, threonine or lysine.. .
Ge Healthcare Bio-sciences Ab
03/19/15
20150079692

Method of determining phenoxy herbicides in water samples by phase transfer microextraction with simultaneous derivatization and gas-chromatography mass-spectrometry analysis


A method for determining the concentration of a phenoxy herbicide in an aqueous sample, by simultaneously phase-transfer catalyst extracting and alkylating an aqueous sample comprising a phenoxy herbicide to form a sample composition, and measuring an amount of the alkylated phenoxy herbicide in the sample composition. The method includes controlling factors such as ph of the aqueous matrix, temperature, extraction duration, type and amount of derivation reagents, and type and amount of phase transfer catalyst..
King Fahd University Of Petroleum And Minerals
03/19/15
20150079691

Catalytic oxidation of polar modifiers in chromatographic mobile phases


The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol.
Waters Technologies Corporation
03/19/15
20150079608

Method for detecting or quantifying analyte, kit for detecting or quantifying analyte, and test strip for lateral flow type chromatography detecting or quantifying analyte


A method for detecting or quantifying an analyte, using a test strip for lateral flow type chromatography which contains a membrane and a detection part on which a capturing ligand that is to specifically bind to the analyte has been fixed on the membrane, includes: bringing an analyte contained in a sample into contact with a labeled ligand labeled with a phosphor that is to be excited by light having a wavelength from 600 nm to 800 nm to generate fluorescence, bringing a complex containing the analyte and the labeled ligand into contact with a capturing ligand at the detection part, and irradiating on the test strip light having a wavelength from 600 nm to 800 nm as an excitation light for the phosphor contained in the complex to generate fluorescence from the phosphor, and measuring a fluorescence intensity of the fluorescence.. .
Konica Minolta, Inc.
03/19/15
20150079601

Methods of nucleic acid fractionation and detection


The invention provides methods of detecting a nucleic acid present in a biological sample, comprising combining the biological sample with a lysis buffer to form a lysis mixture comprising nucleic acid released from cells in said biological sample; and subjecting a volume of the lysis mixture to size-exclusion chromatography in a column comprising a volume of size-exclusion medium. In certain embodiments, the lysis buffer separates double-stranded nucleic acid into single-stranded nucleic acid.
Meridian Bioscience, Inc.
03/19/15
20150079581

Detection kit for influenza a virus


The present invention is a test kit for rapidly diagnosing influenza according to the principles of immunochromatography, and the purpose thereof is to provide a test kit for the influenza a virus in which the sensitivity in detecting the influenza a virus is greater than in conventional test kits, and a determination of “positive” is obtained stably and with high precision at an earlier time during the onset of influenza symptoms. The present invention pertains to a kit for detecting influenza a virus, in which an antibody that is in solid phase in the chromatographic medium enters into an antigen-antibody reaction with native nuclear proteins of the influenza a virus, but in western blots the antibody does not enter into antigen-antibody reactions with full-length nuclear proteins of the influenza a virus that have been separated using sds-polyacrylamide gel electrophoresis..
Tanaka Kikinzoku Kogyo K.k.
03/19/15
20150078962

Microfluidic flame ionization detector


The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber.
Waters Technologies Corporation
03/19/15
20150076342

Method and system for introducing make-up flow in an electrospray ion source system


An electrospray ion source method and system is provided for detecting emitter failure comprising a liquid chromatography column suitable for chromatographic separation of a sample. The column can have an inlet for receiving the sample; and an outlet for ejecting the sample.
Dh Technologies Development Pte. Ltd.
03/19/15
20150076068

Active inlet temperature control for adjustment of retention in a liquid chromatography system


Described are methods in which the retention times of a chromatographic column are adjusted through the control of the temperature of a mobile phase at the inlet to the chromatographic column. The temperature of the mobile phase at the inlet is different from the temperature of the chromatographic column.
Waters Technologies Corporation
03/19/15
20150075374

Gas chromatography using a thermal gradient that is substantially monotonically non-increasing and has a positive second derivative


A system and method for thermal gradient gas chromatography wherein a front or injection end of a column is heated to a higher temperature than a back or detector end to thereby create a thermal gradient having a profile that is substantially monotonically non-increasing and has a positive second derivative, and then providing a heat source to raise the thermal gradient and cause it to remain stationary or to travel through the column while maintaining a desired profile.. .
Brigham Young University
03/19/15
20150075261

Methods of detecting glycosaminoglycans


In one aspect, the disclosure provides methods of distinguishing a glycosaminoglycan from one or more other components in a sample by subjecting the sample to size-exclusion chromatography using a mobile phase having a ph of 6.8 or lower. A mobile phase having a ph of 6.8 or lower is found to improve the separation of glycosaminoglycans from proteins during size exclusion chromatography.
Biogen Idec Ma Inc.
03/12/15
20150073727

Method and improved quantitation by mass spectrometry


A method of quantifying analytes from mass spectral data, comprising: obtaining a first set of mass spectral data from a first set of analytes eluted from a chromatography column; obtaining a second set of mass spectral data from a second set of analytes eluted from a chromatography column; determining apparent abundances of analytes in each data set; selecting a target analyte and determining localised neighboring analytes by their locality to the target analyte with respect to retention time; determining a locally corrected abundance of the target analyte based on differences between the first and second data sets in the apparent abundance of the localised neighboring analytes; and quantifying the target analyte based on its corrected abundance. A majority of the neighboring analytes are typically substantially unchanged in actual abundance between the first and second data sets and can be used for aligning the abundances between the data sets..
Thermo Fisher Scientific (breman) Gmbh
03/12/15
20150073128

Chromatography ligand


The present invention relates to a chromatography ligand defined by the following formula r1—r2—n(r3)—r4—r5 wherein r1 is a substituted or non-substituted phenyl group; r2 is a hydrocarbon chain comprising 0-4 carbon atoms; r3 is a hydrocarbon chain comprising 1-3 carbon atoms; r4 is a hydrocarbon chain comprising 1-5 carbon atoms; and r5 is oh or h. The invention also comprises a separation matrix, comprising the described ligands coupled to a porous support, such as particles or a membrane.
Ge Healthcare Bio-sciences Ab
03/12/15
20150072918

Protein purification


A method for purifying a polypeptide by ion exchange chromatography is described in which a gradient wash is used to resolve a polypeptide of interest from one or more contaminants.. .
Genentech, Inc.
03/05/15
20150065696

Apparatus and process for purification of proteins


The invention is directed to an apparatus and method for purifying a protein. The apparatus involves the use of a capture chromatography resin, a depth filter arranged after the capture chromatography resin, and a mixed-mode chromatography resin arranged after the depth filter.
Abbvie, Inc.
03/05/15
20150065689

Single step fractionation method


Single step method of enriching highly sialylated variant/s of a protein by use of a strong ion exchange chromatography support and a ph gradient in absence of any salt gradient.. .
Dr. Reddy's Laboratories Limited
03/05/15
20150064735

Method for the determination of sequence variants of polypeptides


The current invention is directed to a method for determining amino acid sequence mutations in a produced polypeptide, comprising the following steps of a) providing a sample of a produced polypeptide, b) incubating the polypeptide in the sample with a protease, c) performing a two dimensional analysis using reversed phase chromatography coupled with a high resolution mass spectroscopy (ft-icr/ft-orbitrap) and ms/ms analysis of the amino acid sequence fragments of the peptides, d) data evaluation by comparing the lc-ms data sets obtained for the samples side by side with the data set of a reference sample, by searching for differences in the signal intensities at given retention times and by evaluation of differential signals with respect to amino acid sequence mutations. The reference sample for data evaluation (d) can be either a well characterized standard or one of the samples to be analyzed..
Hoffmann-la Roche Inc.
03/05/15
20150064692

Immunochromatographic test strip and detection method using immunochromatography for detecting target in red blood cell-containing sample


A problem to be solved by the present invention is to provide an immunochromatographic test strip and a detection method using immunochromatography avoiding aggregation of colloidal gold conjugates while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a blood-agglutinating agent and the colloidal gold conjugates as a detection reagent. To solve the problem, the present inventers reviewed a past reagent configuration itself from a completely different viewpoint rather than selecting type and amount of polyanions and, as a result of extensive study on each element, the inventers surprisingly found that aggregation of colloidal gold can be suppressed by using a certain buffer solution without using neutralization by polyanions..
Sekisui Medical Co., Ltd.
03/05/15
20150064093

Mesoporous silica and organosilica materials and process for their preparation


In this invention, we disclose a method as well as silica and/or organosilica mesoporous materials obtained by templating using nanocrystalline cellulose and removal of the latter using acidic conditions. The resultant mesoporous silica materials are characterized by having high surface area with tunable iridescence resulting from the long-range chiral nematic organization.
Fpinnovations
03/05/15
20150060342

Porous adsorptive or chromatographic media


A porous substrate capable of adsorptive filtration of a fluid having a porous self-supporting substrate and one or more porous, adsorptive polymeric coatings comprising from about 1 to about 80% of the void volume of the pores of the substrate. The resultant substrate has good convective and diffusive flow and capacity.
Emd Millipore Corporation
03/05/15
20150059440

Vacuum ultraviolet absorption spectroscopy system and method


An efficient absorption spectroscopy system is provided. The spectroscopy system may be configured to measure solid, liquid or gaseous samples.
Vuv Analytics, Inc.
03/05/15
20150059439

Fluidic devices and methods using them


Certain embodiments described herein are directed to chromatography systems that include a microfluidic device configured to provide three-way switching or switching between three or more inputs or outputs. The microfluidic device can be fluidically coupled to one or more switching valves to provide for selective control of fluid flow in the chromatography system..
Perkinelmer Health Sciences, Inc.
02/26/15
20150057205

Highly aromatic base oil and producing highly aromatic base oil


A method for producing a highly aromatic base oil of the present invention includes a step of hydrorefining a clarified oil to obtain a highly aromatic base oil having an aromatic content of 50% by mass or more determined by a column chromatography analysis method. The step of hydrorefining a clarified oil is preferably performed under conditions of a hydrogen pressure of 5.0 to 20.0 mpa, a temperature of 280 to 400° c., a hydrogen oil ratio of 300 to 750 nl/l, and a space velocity of 0.3 to 2.0 h−1.
Jx Nippon Oil & Energy Corporation
02/26/15
20150056654

Process for the purification of recombinant albumin


A process is provided for the preparation of a highly pure albumin solution the process comprising subjecting albumin (preferably expressed and secreted by transformed yeast) to a series of chromatographic steps. Preferably, the process comprises the steps of positive mode cation exchange chromatography, positive mode anion exchange chromatography, positive mode affinity chromatography, negative mode affinity chromatography (preferably using immobilised aminophenylboronic acid), negative mode cation exchange chromatography, and negative or positive mode anion exchange chromatography.
Novozymes Biopharma Dk A/s
02/26/15
20150056196

Antibody purification by cation exchange chromatography


A method for purifying an antibody by cation exchange chromatography is described in which a high ph wash step is used to remove of contaminants prior to eluting the desired antibody using an elution buffer with increased conductivity.. .
Genentech, Inc.
02/26/15
20150052984

Uv/vis hplc photometer


An ultraviolet-visible spectrophotometry (uv/vis) high-performance liquid chromatography (hplc) photometer includes a nano flow cell in which a light source feeds a reference light channel and a sample light channel, a reference photodiode for evaluating the reference light channel, and a sample photodiode for evaluating the sample light channel, which extends through the nano flow cell. To create a photometer whose signal evaluation is improved, respective effective exposure times of the sample photodiode and the reference photodiode are settable separately from one another..
Sunchrom Wissenschaftliche Geräte Gmbh
02/19/15
20150048015

Corrosion protection in tubing used in chromatography


An apparatus for use in a liquid chromatography system includes a chromatography port and a tubing assembly having a chromatography tube coupled at one end to the chromatography port. The end of the tube has an end face covered with a corrosion-resistant material, for example, gold.
Waters Technologies Corporation
02/19/15
20150047730

Method and sample injection in liquid chromatography


The present invention provides a method and apparatus for substantially eliminating destructive transients of pressure or flow rate which can degrade the efficiency and useful lifetime of chromatography columns. The present invention enables a substantially constant flow of mobile phase liquid to be maintained through the chromatography system by eliminating the flow blockage interval associated with the actuation of sample injection valves.
Waters Technologies Corporation
02/19/15
20150047500

Force balance needle valve pressure regulator for carbon dioxide based chromatography


Exemplary embodiments of the present disclosure relate to systems and methods comprising a dynamic pressure regulator and a force balance needle that regulate pressure changes due to flow or composition changes in a pressurized flow system, such as, for example, a co2-based chromatography system.. .
Waters Technologies Corporation
02/19/15
20150047422

Introducing samples into supercritical fluid chromatography systems


A supercritical fluid chromatography system is provided with an injection valve subsystem for introducing a sample into a flow of mobile phase fluid. The injection valve subsystem includes an auxiliary valve and an inject valve.
Waterstechnologies Corporation
02/12/15
20150045256

Mass spectrometry quantitation of p450 protein isoforms in hepatocytes


A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.
02/12/15
20150044718

On-column enzymatic cleavage


Herein is reported a method for obtaining a polypeptide by an immobilized metal ion affinity chromatography from a pro-polypeptide that comprise at its n- or c-terminus an metal ion affinity chromatography tag and a protease cleavage site comprising the step of recovering the polypeptide from the immobilized metal ion affinity chromatography column by incubating the bound pro-polypeptide with a protease, whereby the immobilized metal ion affinity chromatography material has been washed at least once with an urea solution.. .
Hoffmann-la Roche Inc.
02/12/15
20150044715

Method for analyzing formyl glycine residue


Disclosed is a method which enables semiquantitative or quantitative determination of the ratio between cysteine and formylglycine residues in a protein. The method includes (a) a step of labeling the protein (i) with a halogen-substituted carboxylic acid, (ii) with a halogen-substituted carboxylic acid amide, and (iii) with a halogen-substituted carboxylic acid and then with hydrazine, or with a halogen-substituted carboxylic acid and then by oximation, (b) a step of digesting each labeled protein to provide a corresponding mixture of peptide fragments, (c) a step of subjecting each mixture to reverse phase chromatography to separate the peptide fragments from each other to produce a chromatogram, (d) a step of comparing the produced chromatograms with each other to identify the peak corresponding to the peptide fragment that contained a cysteine residue and the peak corresponding to the peptide fragment that contained a formylglycine residue..
Jcr Pharmaceuticals Co., Ltd.
02/12/15
20150044466

Aqueous silane coupling agent composition, making method, surface treating agent, and article


A composition comprising a silane coupling agent having dicarboxylic acid group and water is provided. The composition has a solid content of 0.5-50 wt % based on the entire composition and a volatile organic compound content of up to 10 wt % based on volatile components which are detectable by headspace gas chromatography.
Shin-etsu Chemical Co., Ltd.
02/12/15
20150044311

Method for extracting and separating ginkgolides


A method for extracting and separating ginkgolides. The ginkgolides obtained through steps of extraction on a ginkgo leaf, further extraction, column chromatography, crystallization, and crystal mixing comprise 25.0% to 50.0% of bilobalide (c15h18o8), 20.0% to 45.0% of ginkgolide a (c20h24o9), 10.0% to 30.0% of ginkgolide b (c20h24o10), and 5.0% to 15.0% of ginkgolide c (c20h24o11).
Chengdu Baiyu Technology Pharmacy Co., Ltd.


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Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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