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This page is updated frequently with new Chromatography-related patent applications. Subscribe to the Chromatography RSS feed to automatically get the update: related Chromatography RSS feeds. RSS updates for this page: Chromatography RSS RSS


Method for producing a chromatography-enrichment column

Commissariat A L'energie Atomique Et Aux Energies Alternatives

Method for producing a chromatography-enrichment column

Ion mobility spectrometer with high throughput

Leco

Ion mobility spectrometer with high throughput


Date/App# patent app List of recent Chromatography-related patents
08/20/15
20150233903 
 Solid phase glycan and glycopeptide analysis and microfluidic chip for glycomic extraction, analysis and methods for using same patent thumbnailSolid phase glycan and glycopeptide analysis and microfluidic chip for glycomic extraction, analysis and methods for using same
Highly specific and novel solid phase methods for analyzing glycans and proteoglycans using a solid phase system are provided. The present invention also provides an integrated apparatus and methods of use which comprises a high-throughput glycan isolation and reverse-phase liquid chromatography (rplc) for on-chip glycan extraction, modification and separation.
The Johns Hopkins University


08/20/15
20150233876 
 Method for producing a chromatography-enrichment column patent thumbnailMethod for producing a chromatography-enrichment column
The invention concerns a method for producing a chromatography-enrichment column, the method comprising the following steps: (a) depositing at least one layer of desired particles, which may be identical or different, and are intended to constitute the stationary phase, in a compact assembly, on the flat surface of a substrate; (b) crosslinking the layer in at least the regions corresponding to the desired shape of the enrichment column to be obtained; (c) impregnating the layer with a light radiation-sensitive material; (d) insolating the layer obtained in step (c) so as to form insolated regions of which the shape corresponds to the desired internal shape of the enrichment column, if the light radiation-sensitive material behaves like a positive resin or to form non-insolated regions of which the shape corresponds to the desired internal shape of the enrichment column if the light radiation-sensitive material behaves like negative resin; and (e) eliminating the light radiation-sensitive material in the zones corresponding to the internal shape of the enrichment column. The invention is used in particular in the field of chemical analysis..
Commissariat A L'energie Atomique Et Aux Energies Alternatives


08/20/15
20150233866 
 Ion mobility spectrometer with high throughput patent thumbnailIon mobility spectrometer with high throughput
A method and apparatus are disclosed for improving ion mobility spectrometry by using a fast and spatially wide ion gate based on local rf field barrier opposed to a switching dc field. Alternatively, the speed and charge throughput of ion mobility separator are improved by arranging coaxial mobility cell followed by conical coaxial ion channel.
Leco Corporation


08/20/15
20150231528 
 Method and  multi column chromatographic purification patent thumbnailMethod and multi column chromatographic purification
A method for separating a feed mixture comprising at least two solutes by an intermittent multi column chromatography process with a basic step n performed in a predetermined switching time period. Basic step n comprises two sub steps which are carried out sequentially according to a predetermined step ratio.
Eth Zurich


08/13/15
20150227071 
 Toner, developer using the toner, image forming apparatus patent thumbnailToner, developer using the toner, image forming apparatus
A toner including at least a crystalline resin as a binder resin, wherein a tetrahydrofuran soluble content of the toner includes 5.0% or more as a peak area of a component having a molecular weight of 100,000 or greater in a molecular weight distribution measured by gel permeation chromatography, and the tetrahydrofuran soluble content of the toner has a weight-average molecular weight of 20,000 to 60,000.. .

08/13/15
20150226712 
 Rotary selector valve and associated systems and methods patent thumbnailRotary selector valve and associated systems and methods
Exemplary embodiments are directed to a rotary selector valve that includes a valve body that includes a rotor and a stator. The stator includes a first port for flow of a first flow material and a second port for flow of a second flow material.
Waters Technologies Corporation


08/13/15
20150226710 
 Method for feeding a sample into an analysis branch of a liquid chromatography system patent thumbnailMethod for feeding a sample into an analysis branch of a liquid chromatography system
The invention relates to a method for feeding a sample into an analysis branch of a liquid chromatography system, in particular a high-performance liquid chromatography system. A solvent or a solvent mixture from at least one solvent branch is supplied as volume flow {dot over (a)} into the analysis branch.
Dionex Softron Gmbh


08/06/15
20150219605 
 Method for producing a chromatography analysis column patent thumbnailMethod for producing a chromatography analysis column
The invention concerns a method for producing a chromatography analysis column, the resulting column, and a device comprising such a column. The method according to the invention comprises the following steps: (a) depositing on the flat surface of a substrate a first layer of particles which are intended to form the stationary phase; (b) depositing on the layer at least one second layer of compactly assembled particles; (c) impregnating the first and second layers with a light radiation-sensitive material, to form at least two compactly assembled particle layers impregnated with sensitive material; (d) insolating these layers in the regions corresponding to the desired internal shape of the chromatography analysis column, if the light radiation-sensitive material behaves like a positive resin, or outlining this internal shape if the light radiation-sensitive material behaves like a negative photosensitive resin; (e) eliminating either the regions insolated in step (d) if the light radiation-sensitive layer behaves like a positive photosensitive resin, or the regions not insolated in step (d) if the light radiation-sensitive material behaves like a negative photosensitive resin; and (f) covering and sealing the structure obtained in step (e) with a cover covered on the face facing the layers with at least one layer of compactly assembled particles which are identical to or different from those deposited on the substrate surface.
Commissariat A L'energie Atomique Et Aux Energies Alternatives


08/06/15
20150219604 
 Chromatography columns patent thumbnailChromatography columns
A chromatography column (2) containing a bed of packed particles (22, 24, 26, 28, 30), wherein the packed particles comprise fused core particles and the particle diameters of the packed particles vary along the column. Preferably, the particles (2, 24, 26, 28, 30) are arranged according to their average particle diameter, in order of increasing average particle diameter from the inlet end (4) to the outlet end (6).
Thermo Electron Manufacturing Limited


08/06/15
20150219603 
 Method for high pressure gradient chromatography using pump stroke control patent thumbnailMethod for high pressure gradient chromatography using pump stroke control
Described is a method of generating a flow having a composition gradient such as a mobile phase gradient for liquid chromatography. A pair of pumps is operated such that the initiations of pump strokes for one pump are controlled to occur between the initiations of pump strokes for the other pump so that the sequences of pump strokes fort the two pumps are interspersed in time.
Waters Technologies Corporation


08/06/15
20150218311 

Method for preparing a composition comprising perfluoropolyether having a carboxyl group at one terminal


An object of the present invention is to provide a method for efficiently and highly selectively preparing a composition comprising a perfluoropolyether having a carboxyl group at one terminal at a higher ratio. The present invention provides a method for increasing a ratio of a perfluoropolyether having a carboxyl group at one terminal, relative to a total amount of the perfluoropolyether having a carboxyl group at one terminal and a perfluoropolyether having carboxyl groups at both terminals in a composition comprising these perfluoropolyethers, wherein the method comprises a step of subjecting the composition to chromatography in which a moving phase is supercritical or subcritical state carbon dioxide of the specific temperature and the specific pressure, and a stationary phase is silica gel to thereby collect a fraction containing the perfluoropolyether having a carboxyl group at one terminal at a higher ratio.
Shin-etsu Chemical Co., Ltd.


08/06/15
20150218208 

Method for purifying antibody by temperature-responsive chromatography


There is provided a method for purifying an antibody using temperature-responsive protein a, wherein different buffer solutions are used in a washing step of washing a stationary phase having the temperature-responsive protein a and in an elution step of eluting the antibody captured by the stationary phase, the method including the washing step of washing the stationary phase using a buffer solution at a temperature at which the temperature-responsive protein a and the antibody are bound and having a first salt concentration, and the elution step of eluting the antibody captured by the stationary phase using a buffer solution at a temperature at which the antibody is released from the temperature-responsive protein a and having a second salt concentration lower than the first salt concentration.. .
Asahi Kasei Medical Co., Ltd.


08/06/15
20150218069 

Removal of organic salts from bio-derived glycol products of polyol hydrogenolysis


A method for reducing contaminants in the production of a bio-derived glycol product of polyol hydro-genolysis is described. The method involves subjecting an aqueous, polyol product mixture (from the hydrogenolysis conversion of biologically-derived carbohydrate feedstock) to ion-exclusion chromatography to separate and reduce impurities from an eluant fraction containing a desired product, and distilling the eluant fraction to yield the desired product (e.g., propylene glycol or ethylene glycol).
Archer Daniels Midland Company


08/06/15
20150216882 

High-purity phospholipids


Novel synthetic routes, which are highly applicable for industrial preparation of therapeutically beneficial oxidized phospholipids, are disclosed. Particularly, novel methods for efficiently preparing compounds having a glycerolic backbone and one or more oxidized moieties attached to the glycerolic backbone, which are devoid of column chromatography are disclosed.
Vascular Biogenics Ltd.


08/06/15
20150216818 

Java ginger extract and manufacturing method


The present invention relates to a java ginger extract which is prepared from java ginger as a starting material and aimed at a concentrate as an objective (concentrate including solid matter) obtained from a solute. The starting material or the products on any of the steps in which the objective is manufactured from the starting material is heated or exposed to sunlight.
Hosoda Shc Inc.


07/30/15
20150212101 

Method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200


The present invention relates to method for the direct detection and/or quantification of at least one compound with a molecular weight of at least 200, wherein the compound to be detected and/or quantified is a chemically complex molecule, wherein said chemically complex molecule is substituted with at least two groups —r, wherein each r group means independently —oh, —op(o)(oh)2 or —p(o)(oh)2, with the proviso that at least two r are independently selected from —p(o)(oh)2 and —op(o)(oh)2, wherein the compound or compounds to be detected and/or quantified are within a biological matrix, wherein said biological matrix is a biological fluid, a biological tissue, stomach contents, intestine contents, stool sample or a culture cells, wherein the method comprises performing a chromatography and identifying the retention time and/or the intensity of the signal by means of a mass or radioactivity detector.. .
Laboratorios Sanifit, S.l.


07/30/15
20150212056 

Separation efficiency in supercritical fluid chromatography


The present technology uses one or more separating segments, i.e. chromatography columns, aligned in series along a flow path.
Waters Technologies Corporation


07/30/15
20150211663 

High pressure fitting for supercritical fluid chromatography


Described is a mobile phase fitting having reduced corrosion and erosion. The fitting includes a coupling body, compression screw, compression member and gasket.
Waters Technologies Corporation


07/30/15
20150210992 

Method for production of recombinant human alpha-galactosidase a


Disclosed is a method for production of recombinant human alpha-galactosidase a (rh alpha-gal a) in a large scale, with a high purity. The method comprises the steps of (a) culturing rh alpha-gal a-producing mammalian cells in a serum-free medium, (b) collecting culture supernatant, (c) subjecting the culture supernatant to anion-exchange column chromatography, (d) to hydrophobic column chromatography, (e) to a column chromatography employing as solid phase a material having affinity for phosphate group, (f) to cation-exchange column chromatography, and (g) to gel filtration column chromatography, in the order..
Jcr Pharmaceuticals Co., Ltd.


07/30/15
20150210754 

Immunoglobulin reduced in thrombogenic agents and preparation thereof


The invention relates to an immunoglobulin composition reduced in thrombogenic agents and to methods for its preparation. One method comprises subjecting an immunoglobulin containing solution to a negative cation exchanger chromatography at a ph in the range of higher than 3.8 to equal to or lower than 5.3.
Omrix Biopharmaceuticals Ltd.


07/30/15
20150210737 

Integrated process for the production of therapeutics (human albumin, intravenous immunoglobulins, clotting factor viii and clotting factor ix) from human plasma


The purification carried out by an all-chromatography scheme, avoids the use of ethanol precipitation in the entire manufacturing process of the said four plasma products. The invention describes an integrated process for purifying four different proteins from human plasma to high therapeutic grade purity levels, with a potential to purify more therapeutic proteins from a given plasma sample by incorporating additional chromatography steps in the sequence..

07/30/15
20150210735 

Isolation and purification of antibodies using protein a affinity chromatography


Disclosed herein are methods for the isolation and purification of antibodies wherein the use of an affinity chromatographic step results in an antibody composition sufficiently pure for pharmaceutical uses. The methods described herein comprise ph viral reduction/inactivation, ultrafiltration/diafiltration, affinity chromatography, preferably protein a affinity, ion exchange chromatography, and hydrophobic chromatography.
Abbvie Inc.


07/30/15
20150209787 

Apparatus and coupling tubing to chromatographihc column


An apparatus for coupling a liquid chromatography column comprising an end fitting to a tubing comprises: at least one body member comprising at least one chamber; a first spring within the at least one chamber, the first spring configured so as to apply a first force to the tubing towards the column end fitting; a second spring within the at least one chamber, the second spring configured to apply a second force to a deformable sealing member towards the column end fitting; and a pushing and latching mechanism configured to push the at least one body member and the first and second springs towards the column end fitting.. .
Thermo Finnigan Llc


07/23/15
20150204889 

Hemoglobin s analysis method, hemoglobin a2 analysis method, and hemoglobin a0 analysis method


The present invention relates to a method for analyzing hemoglobin s by cation-exchange high-performance liquid chromatography, the method including utilizing an eluent that contains an azide or a cyanide at a concentration of 0.1 to 50 mmol/l and has a ph of 6.80 to 7.50.. .

07/23/15
20150204826 

Apparatus and methods for preparative liquid chromatography


Embodiments of the present invention feature methods and apparatus for performing chromatographic separations. The invention feature methods and control means in the form of computer programs and software that control the formation of a concentration gradient at two or more total flow rates, with an elution period occurring in a slow flow rate and at least other portions of the gradient occurring during a fast total flow rate..
Waters Technologies Corporation


07/23/15
20150204825 

Multiple sample chromatography using a stochastic injection technique


The invention relates to a method for simultaneously analyzing at least two samples using a chromatography device comprising a chromatography column having an inlet and an outlet, and at least one detector placed at the outlet of the chromatography column, the method comprising steps of: injecting fractions of each independent sample at the inlet of the chromatography column, the fractions of each independent sample being injected according to a specific injection timing sequence derived from a pseudo-random binary sequence associated with said independent sample; recording a signal generated by said detector for a period of time at least equal to a duration of the longest of the specific injection timing sequences; cross-correlating the recorded signal and a derived correlation function, said derived correlation function being derived from the pseudo-random binary sequence associated with one of the independent samples, so as to obtain an individual correlogram signal specific to said independent sample; and analyzing data of interest of the individual correlogram signal so as to obtain an output signal indicative of a composition of the sample.. .
Chambre De Commerce Et D'industrie De Region Paris Lle De France (esiee Paris)


07/23/15
20150204824 

Materials for hydrophilic interaction chromatography and processes for preparation and use thereof for analysis of glycoproteins and glycopeptides


The invention relates to poly-amide bonded hydrophilic interaction chromatography (hilic) stationary phases and novel hilic methods for use in the characterization of large biological molecules modified with polar groups, known to those skilled in the art as glycans. The invention particularly provides novel, poly-amide bonded materials designed for efficient separation of large biomolecules, e.g.
Waters Technologies Corporation


07/23/15
20150204823 

Self-limiting injection assembly for sample introduction in hplc


A liquid chromatography device comprises one or more liquid reservoirs for a liquid medium, a sample reservoir for a sample to be analysed and a chromatography column in fluid communication with the liquid reservoir and the sample reservoir. The device comprises a monitoring mechanism for monitoring the number of times a sample is released from the sample reservoir into the chromatography column..
Imperial Innovations Ltd


07/23/15
20150203532 

Sterile chromatography and manufacturing processes


Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process..
Genzyme Corporation


07/23/15
20150203531 

Sterile chromatography resin and use thereof in manufacturing processes


Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein..
Genzyme Corporation


07/23/15
20150203530 

Method for isolating and purifying recombinant human serum albumin from transgenic rice grain


A method for separating and purifying recombinant human serum albumin (rhsa) from transgenic rice grain, sequentially comprising the steps of: 1) subjecting crude extract of rhsa to cation exchange chromatography to obtain primary product i; 2) subjecting the primary product ito anion exchange chromatography to obtain secondary product ii; 3) subjecting the secondary product ii to hydrophobic chromatography to obtain purified rhsa. The method may further comprise a step of ceramic hydroxyapatite chromatography prior to the hydrophobic chromatography.
Healthgen Biotechnology Co., Ltd.


07/23/15
20150203529 

Sterile chromatography and manufacturing processes


Provided herein are methods of performing chromatography with gamma-irradiated chromatography resin that include providing a chromatography column including a gamma-irradiated chromatography resin; performing a first cycle of chromatography through the column, where the cycle includes exposing the chromatography resin to a denaturing buffer; and performing at least one additional cycle of chromatography through the column. Also provided are integrated, closed or substantially closed, and continuous processes for manufacturing of a recombinant protein that include the use of at least one chromatography column including gamma-irradiated chromatography resin, where the gamma-irradiated chromatography resin is exposed to denaturing buffer during each cycle in the process, and reduced bioburden buffer is used in the process..
Genzyme Corporation


07/23/15
20150202595 

Sterile chromatography resin and use thereof in manufacturing processes


Provided herein are methods of reducing bioburden of (e.g., sterilizing) a chromatography resin that include exposing a container including a composition including a chromatography resin and at least one antioxidant agent and/or chelator to a dose of gamma-irradiation sufficient to reduce the bioburden of the container and the chromatography resin, where the at least one antioxidant agent and/or chelator are present in an amount sufficient to ameliorate the loss of binding capacity of the chromatography resin after/upon exposure to the dose of gamma-irradiation. Also provided are reduced bioburden chromatography columns including the reduced bioburden chromatography resin, compositions including a chromatography resin and at least one chelator and/or antioxidant agent, methods of performing reduced bioburden column chromatography using one of these reduced bioburden chromatography columns, and integrated, closed, and continuous processes for reduced bioburden manufacturing of a purified recombinant protein..
Genzyme Corporation


07/16/15
20150198574 

Automated microextraction technique for the analysis of n-nitrosoamines in water


An automated headspace solid-phase microextraction coupled with gas chromatography-mass spectrometry for the determination of four n-nitrosoamines in groundwater samples is developed. Response surface methodology technique was employed to investigate the optimized extraction conditions of headspace solid-phase microextraction using combipal autosampler.
King Fahd University Of Petroleum And Minerals


07/16/15
20150198573 

Method and system for liquid chromatography data analysis


One embodiment of the invention is directed to a method of analyzing liquid chromatography data. The method comprises collecting, by a data processing system, first volume fractions data from a first liquid chromatography column for a first absorbance wavelength of light λ1 from a first run of a liquid chromatography process on a mixture, wherein the first liquid chromatography column screens for a first characteristic of the mixture.
Bio-rad Laboratories, Inc.


07/16/15
20150198572 

Chromatographic system and isolating compound in sample using chromatographic system


A method is provided for isolating a compound in a sample by chromatography. The method includes determining an analytical gradient of an analytical system; performing an analytical run using the analytical gradient; identifying a target compound in the sample and determining an analytical retention time of the target compound using chromatographic results of the analytical run; determining an elution point of the target compound using the analytical retention time, the analytical gradient and characteristics of the analytical system; determining automatically a focusing gradient of a preparative system, including a slope segment; and performing a preparative run using the focusing gradient to separate the target compound from the sample.
Agilent Technologies, Inc.


07/16/15
20150198571 

Integrated system for liquid separation and electrospray ionization


The present invention relates to an integrated system for liquid separation, such as lc, ce, affinity chromatography, and ion exchange chromatography. A preferred aspect relates to a specialised protection means for protecting the fragile electrospray needle when not in use.
Proxeon Biosystems A/s


07/16/15
20150198568 

Chromatography column frame and conducting maintenance on and packing of a chromatography column


A chromatography column frame comprising at least two legs, a support arrangement connected to said at least two legs, and a holder connected to said support arrangement. Said holder is arranged to releasably hold an adaptor rod of a chromatography column, so that the adaptor rod is prevented to move in a horizontal direction and so the adaptor rod is allowed to move in a vertical direction..
Ge Healthcare Bio-sciences Ab


07/16/15
20150198567 

Adapter housing and connecting device for chromatography


An adapter housing is described that can be used for high performance liquid chromatography, which can be releasably connected to a socket unit. The adapter housing includes a bore which passes through the adapter housing and a pre-column which can be arranged in the bore to protect the separation column from contaminants and/or to concentrate the fluid to be analyzed.
Dionex Softron Gmbh


07/16/15
20150197795 

Method for detecting single nucleotide polymorphisms


An object of the present invention is to provide a method for rapidly and simply detecting single nucleotide polymorphisms. The present invention is a method for detecting single nucleotide polymorphisms, comprising analyzing wild-type and mutant-type products amplified by an as-pcr method using ion-exchange chromatography..
Sekisui Medical Co., Ltd.


07/16/15
20150197776 

Novel microbial succinic acid producers and purification of succinic acid


The present invention relates to bacterial strains, capable of utilizing glycerol as a carbon source for the fermentative production of succinic acid, wherein said strains are genetically modified so that they comprise a deregulation of their endogenous pyruvate-formate-lyase enzyme activity, as well as to methods of producing organic acids, in particular succinic acid, by making use of such microorganism. The present invention also relates to the downstream processing of the produced organic acids by cation exchange chromatography..
Basf Se


07/16/15
20150196866 

Gas chromatography oven and systems and methods including same


A gas chromatography system includes a gas chromatography oven and a gas chromatography column. The gas chromatography oven includes a housing and a flow generating system.
Perkinelmer Health Sciences, Inc.


07/09/15
20150192550 

Gas analyte spectrum sharpening and separation with multi-dimensional micro-gc for gas chromatography analysis


The disclosure describes embodiments of an apparatus including a first gas chromatograph including a fluid inlet, a fluid outlet, and a first temperature control. A controller is coupled to the first temperature control and includes logic to apply a first temperature profile to the first temperature control to heat, cool, or both heat and cool the first gas chromatograph.
Tricorntech Corporation


07/09/15
20150191505 

Surface neutralization of apatite


The present invention discloses methods of neutralizing apatite surfaces, for example during chromatography and before protein elution.. .
Bio-rad Laboratories, Inc.


07/09/15
20150190733 

Chromatography methods


This application discloses, in part, 1) a stationary phase column and compression designs for preparative chromatography, 2) a method of improving performance of silica gel chromatography by controlling the hydration of silica gel and acidifying the mobile phase, and 3) a method of extending the life of a silica gel column packing by cleaning or regenerating the silica gel stationary phase.. .
Ironstone Separations, Inc.


07/09/15
20150190441 

Extract of asplenium nidus l.


An extract of asplenium nidus l. Includes pyropheophorbide a methyl ester (c34h36n4o3), pheophorbide a methyl ester (c35h36n4o5), 1-linleoyl-3-linolenoyl-glycerol (c39h66o5), 1-linleoyl-2,3-dipalmitoyl-rac-glycerol (c53h98o6) and 1,3-dipalmitoyl-sn-glycerol (c35h68o5).
Academia Sinica


07/02/15
20150185191 

Lamp temperature management liquid chromatography analyzers


A liquid sample analyzer includes a flow cell, a light source, and a lamp temperature management system. The flow cell is configured to receive a flow of a liquid sample from a liquid sample source.
Perkinelmer Health Sciences, Inc.


07/02/15
20150184760 

Injection-compression molded rotors


A shear valve assembly for use in a high performance liquid chromatography system. The shear valve assembly includes a stator having a plurality of first fluid-conveying features; and a rotor having one or more second fluid-conveying features.
Waters Technologies Corporation


07/02/15
20150183843 

Glycoproteins having lipid mobilising properties and therapeutic applications thereof


A biologically active lipid mobilising agent for use in therapy is disclosed which has the properties and characteristics of a zn-α2-glycoprotein, or of a fragment thereof having an apparent molecular mass mr greater than 6.0 kda as determined by gel exclusion chromatography. Methods of isolation and purification from biological material are also disclosed together with uses of the material for making up pharmaceutical compositions, especially pharmaceutical compositions useful for treating mammals to achieve weight reduction or for controlling obesity.
Aston University


07/02/15
20150183820 

Scavenger containing protein formed from tandem-type multimer of mutant extracellular domain of protein g


The present invention relates to a capturing agent for an antibody, immunoglobulin g or a protein comprising an fc region of the immunoglobulin g, wherein a protein consisting of a tandem-type multimer of extracellular domain mutants that have binding property to the protein comprising the fc region of the immunoglobulin g is immobilized to a water-insoluble solid support via mainly an amino group, and a column for a chromatography for separating and purifying the protein, which is filled with the capturing agent.. .

06/25/15
20150177199 

Method and characterizing impurity profile of organic materials


Method and apparatus for characterizing drug-modified polymers, macromolecules, proteins, antigens, antibodies or nanoparticles and quantitative determination of their impurity profile by two-dimensional liquid chromatography analysis. The first dimension is preferably size exclusion chromatography (sec)—which is also known as gel permeation chromatography in case of non-aqueous samples (gpc)—for complete molecular weight analysis of nanoscale particles.
Bbs Nanotechnology Ltd.


06/25/15
20150177148 

Crosstalk reduction


Techniques are disclosed relating to analysis and reduction of crosstalk between signals. These techniques may be applicable in many fields, such as single-tube pcr or dna melt analysis, pcr or melt data from neighboring wells of a multi-well plate, capillary electrophoresis data (e.g., dna sequencing), gas chromatography, multispectral imaging, dual-color fluorescence correlation spectrometry, electrical crosstalk, etc.
Luminex Corporation


06/25/15
20150176066 

Inspection tool for nucleic acid chromatography


An inspection tool for nucleic acid chromatography includes an elongated porous sheet and a backing member. The porous sheet has a surface including a detection surface that has a strip-shaped indication portion where a nucleic acid probe for capturing the target nucleic acid is fixed.
Ngk Insulators, Ltd.


06/25/15
20150174553 

Porous composite particulate materials, methods of making and using same, and related apparatuses


In an embodiment, a porous composite particulate material includes a plurality of composite particles. Each composite particle includes an acid-base-resistant core particle at least partially surrounded by one or more layers of acid-base-resistant shell particles.
Brigham Young University


06/18/15
20150170776 

Method and the production of lead 212 for medical use


The invention relates to a method for preparing lead (212) for medical use. This method comprises the production of lead (212) by the decay of radium (224) in a generator comprising a solid medium to which the radium (224) is bound, followed by the extraction of the lead (212) from the generator in the form of an aqueous solution a1, characterised in that the lead (212) contained in the aqueous solution a1 is purified from the radiological and chemical impurities, also contained in said aqueous solution, by a liquid chromatography on a column.
Areva Med Sas


06/18/15
20150168585 

Methods for compositional analysis of downhole fluids using data from nmr and other tools


Apparatus and methods of analyzing a composition of a hydrocarbon-containing fluid including using a nuclear magnetic resonance (nmr) tool to conduct a nmr relaxation measurement, a diffusion measurement, or both on the hydrocarbon-containing fluid to obtain nmr data, using a non-nmr tool to conduct an additional measurement of a reference fluid to obtain non-nmr data wherein the additional measurement comprises gas chromatography, optical observation, or both, and using the nmr data and the non-nmr data in an inversion process to determine an indication of the composition of the hydrocarbon-containing fluid. In some embodiments, the indication is determined over 4 chain length nodes..
Schlumberger Technology Corporation


06/18/15
20150166987 

Programmable and reconfigurable microcolumn affinity chromatograpy device, system, and methods of use thereof


The present invention generally relates to microcolumn affinity chromatography devices, systems that include the microcolumn affinity chromatography devices of the present disclosure, methods of using the devices and the systems of the present disclosure, and methods of making the devices and the systems of the present disclosure. In certain embodiments, the microcolumn affinity chromatography device is suitable for conducting affinity chromatography in multiple microcolumns in parallel and/or in series..
Cornell University


06/18/15
20150166705 

Method for producing polymer particles, polymer particles, filler for chromatography column, and chromatography column


To provide a method for producing polymer particles from an acrylamide monomer by a normal phase suspension polymerization method, polymer particles, a packing material for a chromatography column using the particles, and a chromatography column. A method for producing polymer particles, comprising dispersing a monomer composition comprising a multifunctional monomer having a plurality of n-substituted acrylamide groups in an aqueous medium; and polymerizing the dispersed monomer composition..
Jsr Corporation


06/18/15
20150166653 

Low acidic species compositions and methods for producing and using the same using displacement chromatography


The present invention relates to low acidic species (ar) compositions comprising a protein, e.g., an antibody, or antigen-binding portion thereof, and methods for producing such low ar compositions using displacement chromatography. Methods for using such compositions to treat a disorder, e.g., a disorder in which tnfα is detrimental, are also provided..
Abbvie, Inc.


06/18/15
20150166353 

Porous silica powder


An object of the present invention is to provide a porous silica powder suitable for, for example, a gas chromatography support, and the porous silica powder has an average pore diameter of 0.5 to 10 μm as determined by a mercury intrusion method, a volume of pores having a 100 nm or smaller pore diameter of 0.2 cm3/g or less as determined by a nitrogen gas adsorption method, a specific surface area of 0.5 to 100 m2/g as determined by a nitrogen gas adsorption method, and a particle size distribution of 10 to 1000 μm.. .
Shinwa Chemical Industrial Ltd.


06/18/15
20150165343 

Multidimensional liquid chromatography separation system and separation protein separation


A multidimensional liquid chromatography separation system has a mobile-phase storage tank, a first liquid transfer device, a second liquid transfer device, a first sample introduction device, a second sample introduction device, a separation device, a collection, storage device, at least two drainage devices and a flow path switching device. A separation method for protein separation using the multidimensional liquid chromatography separation system has the steps of: 1) preparation in advance, 2) the first dimensional separation, 3) collection and storage of the intermediate fraction, 4) the second dimensional or multidimensional separation and repeating the steps 3) and 4)..
Northwest University


06/18/15
20150165342 

Apparatus and methods for preparative liquid chromatography


A method of liquid chromatography includes providing one or more solvent reservoirs, providing a solvent pump, drawing one or more solvents into the pump in response to a pressure drop that promotes outgassing of the solvents, and dispersing outgassed bubbles into smaller bubbles to promote re-dissolution of the gas. A liquid-chromatography apparatus includes at least two solvent reservoirs, a pump, at least one bubble-dispersing unit that receives a pressurized flow of proportioned solvents from the pump, and a control unit.
Waters Technologies Corporation


06/11/15
20150160203 

Freeze-dried conjugate structure for point-of-care testing (poct) immunochromatography, immunoassay kit comprising the same, and analysis using the kit


In addition, the freeze-dried conjugate structure of the present invention can be provided in a state in which it is received in a chamber additionally comprising a cap. Thus, it can be stored without contamination and is easy to carry.

06/11/15
20150160173 

Thin layer chromatography plates and related methods


In an embodiment, a method for manufacturing a thin layer chromatography (“tlc”) plate is disclosed. The method includes forming a layer of elongated nanostructures (e.g., carbon nanotubes), and at least partially coating the elongated nanostructures with a coating including silicon nitride.
Brigham Young University


06/11/15
20150160170 

Chromatography column distribution system


A chromatography column distribution system includes a set of first bed support ribs extending radially from an inner, first radial position near the centre of the plate to an outer radial position nearer to the periphery of the plate and at least one set of intermediate bed support ribs starting at an intermediate radial position and extending to an outer radial position nearer to the periphery of the plate. Channels are formed between adjacent bed support ribs.
Ge Healthcare Bio-sciences Ab


06/11/15
20150158877 

Dualistic substituted phthalocyanine zinc formula, process of separating the same and use thereof


The invention discloses a pharmaceutical formula used in photodynamic therapy (pdt) for cancer or precancerous lesions. The formula includes four components of disulfonic acid diphthaloyl iminomethyl dualistic substituted phthalocyanine zinc alkali salt.
Fuzhou University


06/11/15
20150157959 

Techniques for accelerating thermal equilibrium in a chromatographic column


Techniques are described for accelerating thermal equilibrium in a chromatographic column. An apparatus comprises a chromatography column, and a plurality of temperature control units in thermal contact with the chromatography column.
Waters Technologies Corporation


06/04/15
20150151276 

Chromatography media and use thereof


The present invention relates to a novel non-cross linked chromatography media provided with glutathione ligands which may or may not be provided with magnetic particles. The chromatography media is used for production of an affinity media provided with gluthatione ligands for adsorption of gst-tagged proteins..
Ge Healthcare Bio-sciences Ab


05/28/15
20150148545 

Protein tyrosine phosphatase inhibitor, preparation method and uses thereof


Disclosed in the present invention is a protein tyrosine phosphatase inhibitor. The preparation method therefor is: extracting the crude product from the isaria fumosorosea wize solid or liquid fermentation broth using ethyl acetate, ethanol, methanol, or a mixed solvent of chloroform and methanol; separating the obtained extract using column chromatography on silica gel; and obtaining the target product.
Hebei University


05/28/15
20150147451 

Novel food and feed antioxidants and preservatives based on antioxidant enzymes extracted from animal blood


Disclosed is a process for extracting an antioxidant cocktail (containing a number of antioxidative molecules including but not limited to superoxide dismutase (sod), catalase, glutathione, glutathione peroxidase) from animal sources (i.e., blood or liver) so that it can be used as a food and feed preservative in a non-purified state to prevent rancidity. The antioxidant can also be used in other products such as oils, paint, caulking, plastics, or any other product exposed to oxidation.
Clemson University


05/28/15
20150144782 

Systems, devices, and methods for connecting a chromatography system to a mass spectrometer


The invention provides interfaces between analytical instruments, e.g., between chromatography systems and mass spectrometers. In an exemplary embodiment, an ion source is provided for connecting a carbon dioxide-based chromatograph device to a mass spectrometer.
Waters Technologies Corporation


05/28/15
20150143880 

High performance liquid chromatography with uv-visible detection


Apparatus and methods for high performance liquid chromatography. The apparatus includes a preparation loop comprising two linear stepping pumps, a sample loop comprising a sample injector, a chromatography column, and a detector device.
Academia Sinica


05/21/15
20150141688 

Purification of chlorosilanes using chromatography


The present invention relates to a method for separating organohalosilanes. The method includes introducing a mixture including at least a first organohalosilane and a second organohalosilane onto a chromatographic bed including a stationary phase.
Dow Corning Corporation


05/21/15
20150141623 

Protein purification methods to reduce acidic species


The instant invention relates to the field of protein production and purification, and in particular to compositions and processes for controlling the amount of charge variants, aggregates, and fragments of a protein of interest, as well as host cell proteins, present in purified preparations by applying particular chromatography conditions during such protein purification.. .
Abbvie, Inc.


05/21/15
20150140600 

Mass spectrometry quantitation of p450 isoforms in hepatocytes


A method for screening a drug for cytochrome p450 (cyp) induction is provided and can include incubating the drug with a microsome-containing biological sample and then quantitating at least one cytochrome p450 isoform. The isoforms can be selected from 2b6, 3a4, 1a2, and 3a5 isoforms.
Dh Technologies Development Pte. Ltd.


05/21/15
20150140593 

Retention index standards for liquid chromatography


A homologous series of neutrally charged compounds having at least one functional group bearing a positive charge and at least one functional group bearing a negative charge are advantageous retention index standards for liquid chromatography, especially for liquid chromatography-mass spectrometry (lc-ms) methods, more especially for lc-ms methods employing electrospray (esi) or atmospheric pressure chemical ionization (apci) ionization systems.. .
National Research Council Of Canada


05/21/15
20150140266 

Biaxially stretched polypropylene film for capacitors


A biaxially stretched polypropylene film for a capacitor containing an isotactic polypropylene. The weight average molecular weight (mw) of the isotactic polypropylene as measured by gel permeation chromatography (gpc) is 250,000 to 450,000, the molecular weight distribution mw/mn is 7 to 12 and mz/mn is 20 to 40, and the value of a difference obtained by subtracting a differential distribution value when the logarithmic molecular weight log(m)=6 from a differential distribution value when log(m)=4.5 on a molecular weight distribution curve thereof is 8% to 20%.
Oji Holdings Corporation


05/21/15
20150139944 

Separatone-based protein expression and purification platform


Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of e. Coli, yeast, bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc.
Board Of Trustees Of The University Of Arkansas


05/21/15
20150136700 

Chromatographic materials


The present invention provides a chromatographic stationary phase material various different types of chromatography. One example chromatographic stationary phase is represented by formula 1 [x](w)a(q)b(t)c (formula 1).
Waters Technologies Corporation


05/21/15
20150135861 

Pre-column heating of mobile phase solvent in chromatography systems


An apparatus for heating a flowing fluid includes a tubing assembly, a heater block made of thermally conductive material, and a heater cartridge in thermal communication with the heater block. The heater cartridge is configured to provide heat to the heater block for transfer to fluid flowing through the tubing assembly.
Waters Technologies Corporation


05/14/15
20150133294 

Chromatographic materials


In one aspect, the present invention provides a chromatographic stationary phase material for various different modes of chromatography represented by formula 1: [x](w)a(q)b(t)c (formula 1). X can be a high purity chromatographic core composition having a surface comprising a silica core material, metal oxide core material, an inorganic-organic hybrid material or a group of block copolymers thereof.

05/14/15
20150132781 

Multiplexed chromatography-immunoassay the characterization of circulating immune complexes


Thus, herein is reported a method for analyzing/characterizing circulating immune complexes (cics) formed in vivo comprising a size-exclusion chromatography of a sample obtained from a mammal to which the drug had been administered at least once for determining the weight/size of the immune complexes, optionally a second non-sec chromatography, and at least one immunoassay, whereby the immune complex is characterized by the correlation of the immune complex size and the immunoassay result/read-out. Also reported herein is the use of a method as reported herein for determining a correlation to altered pharmacokinetics, for determining loss or reduction of efficacy, for determining neutralization of natural counterparts of the drug, for determining immune and hypersensitivity reactions, including serum sickness/type iii hypersensitivity reaction/immune complex-mediated disease..

05/14/15
20150132241 

Antiperspirant active compositions having sec chromatogram exhibiting high sec peak 4 intensity


An aluminum salt composition comprising (a) an aluminum salt having an aluminum to chloride molar ratio of about 0.3:1 to about 3:1, an oh:al molar ratio of about 2:1 to about 2.6:1, exhibiting a size exclusion chromatography (sec) chromatogram having a sec peak 4 to peak 3 intensity ratio of at least 7, and a peak 4 intensity greater than a peak 5 intensity in aqueous solution, and (b) at least one buffer chosen from an amino acid, glycine, and betaine, wherein a molar ratio of buffer to aluminum is about 0.1:1 to about 3:1.. .

05/14/15
20150129501 

Flash chromatography column apparatus


A flash chromatography apparatus which provides an improved apparatus for large and medium commercial scale flash chromatography columns. More particularly, the invention relates to a flash chromatography column and cartridge system for positioning and ease of loading and unloading of stationary phase agent in the flash chromatography column.

05/14/15
20150129474 

Techniques for thermally insulating a liquid chromatographic column


An apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column wherein the insulating member is formed from a vacuum chamber surrounding the chromatography column. Another apparatus for performing liquid chromatography includes a chromatography column, and an insulating member surrounding the chromatography column, wherein the insulating member includes aerogel.

05/14/15
20150128685 

Sampling device


The invention relates to a sampler for providing a sample for high-performance liquid chromatography, in which a volume of liquid to be taken up into a cylinder can be aspirated by means of a first drive and can be compressed to a high pressure level by means of a second drive independent of the first drive or can be decompressed from this level in a controlled manner.. .

05/07/15
20150126764 

Method for the purification of prostaglandins


The present invention provides a method for the purification of a prostaglandin by supercritical fluid chromatography, said method comprising the use of a stationary phase and a mobile phase comprising carbon dioxide, provided that when the stationary phase is unmodified silica gel, the prostaglandin is not luprostiol. The invention also provides prostaglandins obtainable by the method..
Johnson Matthey Public Limited Company


05/07/15
20150126760 

Highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester with reduced environmental pollutants, and producing same


A highly unsaturated fatty acid or a highly unsaturated fatty acid ethyl ester that has been produced using as a feedstock oil a fat or oil that contains highly unsaturated fatty acids as constituent fatty acids and which has been reduced in the contents of environmental pollutants, wherein among the dioxins contained, polychlorinated dibenzoparadioxins (pcdds) and polychlorinated dibenzofurans (pcdfs) are contained in amounts of less than 0.05 pg-teq/g and coplanar pcbs (co-pcbs) in amounts of less than 0.03 pg-teq/g. Also disclosed is a method for producing the highly unsaturated fatty acid or highly unsaturated fatty acid ethyl ester by the steps of removing free fatty acids and environmental pollutants by thin-film distillation from a feedstock oil, ethyl esterifying the resulting fat or oil, and refining the same by rectification and column chromatography..
Nippon Suisan Kaisha, Ltd.


05/07/15
20150126715 

Highly glycosylated long-acting human growth hormone protein and production same


The present invention relates to a long-acting human growth hormone nexp-hgh protein and its production method. More specifically, it relates to a specific isoform of long-acting human growth hormone nexp-hgh protein in which human growth hormone is fused with a highly glycosylated alpha-1 antitrypsin mutant whereby long-acting properties in vivo are increased.
Alteogen, Inc.


05/07/15
20150126700 

Curable resin composition and cured product thereof, encapsulating agent, and optical semiconductor device


The curable resin composition includes a compound (u) containing an aliphatic carbon-carbon unsaturated bond and a compound (h) containing a hydrosilyl group and includes at least one of a ladder-type silsesquioxane [a1] and a ladder-type silsesquioxane [a2], where the ladder-type silsesquioxane [a1] contains an aliphatic carbon-carbon unsaturated bond and has a number-average molecular weight of 500-1500 and a molecular weight dispersity (mw/mn) of 1.00-1.40 as determined by gel permeation chromatography and calibrated with a polystyrene standard, and the ladder-type silsesquioxane [a2] contains a hydrosilyl group and has a number-average molecular weight of 500-1500 and a molecular weight dispersity (mw/mn) of 1.00-1.40 as determined by gel permeation chromatography and calibrated with a polystyrene standard.. .

05/07/15
20150126403 

Method of identifying proteins in human serum indicative of pathologies of human lung tissues


A method of identifying proteins present in human serum which are differentially expressed between normal individuals and patients known to have non-small cell lung cancers and asthma, as diagnosed by a physician. Human serum specimens from each population are digested with trypsin or any other suitable endoproteinase and analyzed using a liquid chromatography electrospray ionization mass spectrometer.
Cancer Prevention And Cure, Ltd




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Chromatography topics: Chromatography, Chromatograph, Antibodies, Mass Spectrometry, Spectrometry, Quantitative, High Resolution, Switching Valve, Cross Section, Protein A Affinity Chromatography, Amino Acid, Silica Gel, Carboxylic Acid, Antifungal, Isoleucine

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