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Cholesterol patents



      
           
This page is updated frequently with new Cholesterol-related patent applications. Subscribe to the Cholesterol RSS feed to automatically get the update: related Cholesterol RSS feeds. RSS updates for this page: Cholesterol RSS RSS


Date/App# patent app List of recent Cholesterol-related patents
11/20/14
20140343321
 Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism patent thumbnailnew patent Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
The invention relates to plasminogen activator-1 (pai-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated pai-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated pai-1, cholesterol, or lipid levels..
11/20/14
20140341974
 Liposomal vaccine adjuvants and methods of making and using same patent thumbnailnew patent Liposomal vaccine adjuvants and methods of making and using same
A vaccine adjuvant composition comprising: a lipid selected from the group consisting of: dipalmitoyl phosphatidicholine (dppc), dipalmitoyl phosphatidylglycerol (dppg), dioleoyl phosphatidylcholine (dopc), and cholesterol and containing a positively or negatively charged lipid with associated/entrapped protein antigen.. .
11/13/14
20140336395
 Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid patent thumbnailSalt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
Novel salt forms of [r—(r*,r*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid characterized by their x-ray powder diffraction pattern and solid-state nmr spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and alzheimer's disease.. .
11/13/14
20140336220
 Composition for preventing or treating obesity comprising rebamipide patent thumbnailComposition for preventing or treating obesity comprising rebamipide
The present disclosure relates to a composition and a health functional food for preventing or treating obesity comprising a rebamipide compound or its pharmaceutically acceptable salt as an active component. It is confirmed that when a rebamipide compound of the present disclosure is administered to a mouse model induced with obesity, it shows excellent effects of reducing weight, reducing adipocyte, and reducing a total cholesterol content in the body, as compared with a non-administered control group, and also, it shows an excellent effect of suppressing differentiation of cytotoxic th17 cells that generate and secrets inflammatory cytokine and an excellent effect of improving activity of regulatory t cells (treg) capable of suppressing a function of abnormally activated immune cells and controlling an inflammatory reaction.
11/13/14
20140336113
 Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome patent thumbnailCompositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject.
11/13/14
20140335066
 Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile patent thumbnailLactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile
A microorganism strain lactobacillus plantarum inducia dsm 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L.
11/06/14
20140328851
 Cholesterol ester transfer protein (cetp) inhibitor polypeptide antibodies for prophylactic and therapeutic anti-atherosclerosis treatments patent thumbnailCholesterol ester transfer protein (cetp) inhibitor polypeptide antibodies for prophylactic and therapeutic anti-atherosclerosis treatments
Herein are described two antibodies that can inhibit cetp-lipoproteins interaction and cetp activity. Presently described are an antibody or fragment thereof capable of specifically binding to an epitope of the n-terminal or c-terminal domains of cetp and methods of using these antibodies for separation, identification, diagnosis and therapy..
10/30/14
20140323548
 Novel amino alcohol cationic lipids for oligonucleotide delivery patent thumbnailNovel amino alcohol cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids.
10/30/14
20140322735
 Method to measure endogenous enzymatic serum/plasma cholesterol esterification by lcat (lecithin:cholesterol acyltransferase) assay patent thumbnailMethod to measure endogenous enzymatic serum/plasma cholesterol esterification by lcat (lecithin:cholesterol acyltransferase) assay
The present invention provides a method for the assessment of cholesterol esterification through physiologically relevant pathways and incorporates the function of individual subject's endogenous hdl particles. This ex vivo approach avoids the use of an artificial substrate and provides for determination of lcat activity that includes both the contribution of a subject's endogenous hdl function and endogenous lcat protein, and is therefore a significant improvement to the biologic relevance..
10/23/14
20140316124
 Modidifed irna  agents patent thumbnailModidifed irna agents
The invention relates to irna agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the irna agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety.
10/23/14
20140315928
Substituted amide compounds
The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as ldl-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of ldl-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.. .
10/23/14
20140315873
Animal feed including cationic cholesterol additive and related methods
Methods and feed compositions for increasing health of agricultural animals include administering a cationic cholesterol additive through the diet of the animal, such as through solid feed or drinking water of the animals. The method includes feeding an animal a diet comprised of a cationic cholesterol additive, such as a compound with a sterol backbone and a plurality of cationic groups attached thereto.
10/23/14
20140314844
Oral complex formulation comprising omega-3 fatty acid and hmg-coa reductase inhibitor with improved stability
The present invention relates to an oral complex formulation comprising omega-3 fatty acid or its derivatives encapsulated in a hard or soft capsule containing sorbitol and sorbitan, as well as an hmg-coa reductase inhibitor. The formulation of the present invention comprising omega-3 fatty acid encapsulated with sorbitol and sorbitan provides better prevention related materials from being formed, leading to improved long-term storage stability.
10/23/14
20140314729
Nutraceutical formulation for treatment of elevated cholesterol and cardiovascular disease
Disclosed are compositions of matter useful for the treatment of elevated blood cholesterol. In one embodiment a nutraceutical composition is administered to a patient in need of said composition comprising of the following combination of ingredients: policosanol, niacin, guggul, garlic, cynara scolymus, red yeast rice, ginger, holy basil, l-carnitine, chromium picolinate, coenzyme q10, pantothenic acid, grape seed extract, momordica charantia, and garcinia indica..
10/16/14
20140309295
Antiepileptic, hypocholesterolemic and neuroprotective compound
Its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of the compound and of its hydroxy acid form and, in particular, said compound, its hydroxy acid form, salts, etc. For its use in the prevention of: neurodegenerative diseases, cognitive deterioration, diseases associated with undesired oxidation, age-associated pathological processes and progeria, epilepsy, epileptic seizures and convulsions, cardiovascular diseases such as atherosclerosis, atrial fibrillation, dyslipemia, hypercholesterolemia, hyperlipidemia, and hypertriglyceridemia, or fungal or viral infections..
10/16/14
20140308340
Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of acyl-coa:cholesterol acyltransferase 1, but not acyl-coa:cholesterol acyltransferase 2.. .
10/16/14
20140308304
Lipids for the delivery of active agents
The present invention relates to novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mrna both in vitro and in vivo. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol.
10/09/14
20140303380
Process for a cetp inhibitor
An efficient process is disclosed for producing the compound of formula i, which is the cetp inhibitor anacetrapib, which raises hdl-cholesterol and reduces ldl-cholesterol in human patients and may be effective for treating or reducing the risk of developing atherosclerosis:. .
10/09/14
20140303209
Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an mtp inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the mtp inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the mtp inhibitor to the subject.
10/09/14
20140302128
Biological oil composition, formulations comprising the oil composition, and use thereof to prevent or treat cardiovascular disease
This invention relates to a biological oil composition, preferably obtained from a copepod, most preferably the copepod calanus finmarchicus and the use thereof to prevent or treat formation of atherosclerotic plaques and hence development of coronary heart disease. The composition comprises the same marine n-3 polyunsaturated fatty acids (pufas) generally regarded as being responsible for the anti-atherosclerotic effect of marine oils, namely epa (c20:5n-3 eicosapentaenoic acid) and dha (c22:6n-3 docosahexaenoic acid).
10/09/14
20140301968
Antimicrobial cationic polycarbonates
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups.
10/09/14
20140301967
Antimicrobial cationic polycarbonates
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups.
10/02/14
20140296305
Use of quaternary pyridinium salts as vasoprotective agents
Wherein r is nh2, ch3, or n(h)ch2oh group, and x is pharmaceutically acceptable counterion, for the preparation of vasoprotective agent for the treatment or prevention of conditions or diseases associated with dysfunction of vascular endothelium, oxidative stress, and/or insufficient production of endothelial prostacyclin pgi2, in particular but not exclusively if the above coincides with hypercholesterolemia, hypertriglyceridemia or low hdl level.. .
09/25/14
20140288187
Cocoa-based food products
The invention is concerned with food products comprising one or more cocoa bean products and a carotenoid compound, particularly with food products which are, or comprise, chocolate. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation..
09/25/14
20140288072
5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester-transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis
The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (i), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein r, r1, r2, ra, raa, rb and n are as defined herein.
09/25/14
20140287994
Peptides having reduced toxicity that stimulate cholesterol efflux
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., apo ai and apo e), and having high selectivity for abca1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses.
09/25/14
20140287479
Modified lecithin-cholesterol acyltransferase enzymes
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying lcat polypeptide.. .
09/25/14
20140287128
Emulsified liquid seasoning
Provided is a low-calorie, low-cholesterol emulsified liquid seasoning in which syneresis, separation, and setting are suppressed. The emulsified liquid seasoning includes a crosslinked starch, an octenyl succinate-treated starch, and a polysaccharide thickener.
09/25/14
20140286945
Enzyme inhibitor for cancer treatment
Disclosed herein is a new and improved therapy for the treatment of diseases including cancer, which comprises the step of altering cell membrane lipid composition by treating a cancer cell with an enzyme inhibitor which inhibits enzymes regulating the cholesterol biosynthetic pathway. The method may also be employed in combination with existing chemotherapeutic agents to combat the drug resistance and enhance the therapeutic efficacy of conventional therapy..
09/18/14
20140276344
Shunting of dietary lipids including cholesterol
Methods and devices for redirecting at least a portion of a fluid from the mesenteric lymphatic system for elimination from the body are disclosed. The fluid may be redirected for elimination through the urinary system or redirected outside the body.
09/18/14
20140275227
Compositions and methods of altering cholesterol levels
The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmrna molecules.. .
09/18/14
20140275207
Antisense compounds and methods of use thereof
Disclosed herein are compounds, compositions and methods for modulating the expression of lmw-ptpase in a cell, tissue or animal. Also provided are methods of target validation.
09/18/14
20140274946
Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia
The method of using nutritional compounds including dihydroquercetin (taxifolin). Arabinogalactan and arabinogalactan combined with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors, associated with metabolic syndrome and hypercholesterolemia in a mammal, specifically a human, resulting in the enhancement of metabolism, reduced control levels of cholesterol and triglycerides, reduced oxidative damage in humans and other health benefits..
09/18/14
20140273027
Serological methods and diagnostic tests for syphilis antibodies
A non-treponemal diagnostic test for syphilis infection includes initially dissolving cholesterol in an organic solvent and further diluting the dissolved cholesterol in an ethanol solution comprising cardiolipin and lecithin, permitting a volume of the antigen solution to evaporate in place within a container, rinsing the coated container with buffered saline, stabilizing the antigen coating by overcoating the antigen coating with an inert protein dissolved in buffered saline, decanting the overcoat solution, air-drying the container, and sealing the container in vapor-proof pouches with desiccant, providing an enzyme-labeled conjugate component of a syphilis infection test that is formulated to be compatible with a lipid nature of the cholesterol, the cardiolipin, and the lecithin vdrl antigens, providing a sample diluent that is formulated to be compatible with the lipid nature of the vdrl antigens, and providing a wash fluid that is formulated to be compatible with the lipid nature of the vdrl antigens.. .
09/18/14
20140272080
Spread
A spread or margarine which is intended to serve as a tasty, indulgent product and at the same time provide good health benefits to the consumer. The spread combines high levels both of monounsaturated fatty acids, which are thought to be a beneficial component of the mediterranean diet, and linoleic acid, a known ldl-cholesterol lowering moiety.
09/18/14
20140271998
Fortified egg white products
Egg products are produced which contain healthy components of egg yolks and egg whites, such as choline, lutein, omega-3 fatty acids, vitamins and minerals, but do not contain the unhealthy components of egg yolks such as cholesterol and triglycerides. The healthy yolk components or nutrients are added to egg whites to obtain a yolk-less egg product having the taste, color, and functionality of whole eggs and whole egg products.
09/18/14
20140271821
Liposomal cisplatin compositions for cancer therapy
The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-65 mol % of a phosphatidylcholine lipid, 30-45 mol % of cholesterol, and 2-8 mol % of a peg-lipid; and cisplatin. Cisplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the cisplatin weight is from about 65:1 to about 95:1.
09/18/14
20140271820
Liposome oxaliplatin compositions for cancer therapy
The present invention provides a composition for the treatment of cancer including zwitterionic liposomes consisting essentially of: 50-70 mol % of a phosphatidylcholine lipid, 25-45 mol % of cholesterol, and 2-8 mol % of a peg-lipid; and oxaliplatin. Oxaliplatin is encapsulated in the liposomes in an amount such that the ratio of the total lipid weight to the oxaliplatin weight is from about 20:1 to about 65:1.
09/18/14
20140271815
Heat-and freeze-stable vaccines and methods of making and using same
A vaccine adjuvant composition comprising: a lipid selected from the group consisting of: dipalmitoyl phosphatidlcholine (dppc), dipalmitoyl phosphatidylglycerol (dppg), dioleoyl phosphatidylcholine (dopc), and cholesterol and containing a positively or negatively charged lipid with associated/entrapped protein antigen.. .
09/18/14
20140271796
Oxybutynin-containing transdermal absorption preparation
A transdermal absorption preparation containing at least one drug selected from oxybutynin and pharmaceutically acceptable salts thereof and 0.05% by mass or more of a sterol selected from cholesterols, cholesterol derivatives and cholesterol analogs, relative to a total amount of the transdermal absorption preparation.. .
09/11/14
20140255959
Cholesterol oxidase mutants, compositions, devices, kits and uses thereof
Compositions, devices, kits and methods are disclosed for assaying cholesterol with a cholesterol oxidase mutant that has been modified at an amino acid residue involved in the active site. The cholesterol oxidase mutant has reduced oxidase activity while substantially maintaining its dehydrogenase activity..
09/11/14
20140255539
Nutritional compositions containing structured fat globules and uses thereof
The present disclosure relates to a lipid source for nutritional compositions, comprising an enriched lipid fraction which comprises structured fat globules. The enriched lipid fraction provides fat globules having a desired size and fatty acid composition and may be stabilized by components such as phospholipids, cholesterol, milk-fat globule membrane protein and combinations thereof.
09/11/14
20140255538
Nutritional compositions containing structured fat globules and uses thereof
The present disclosure relates to a lipid source for nutritional compositions, comprising an enriched lipid fraction which comprises structured fat globules. The enriched lipid fraction provides fat globules having a desired size and fatty acid composition and may be stabilized by components such as phospholipids, cholesterol, milk-fat globule membrane protein and combinations thereof.
09/11/14
20140255537
Nutritional compositions containing an enriched lipid fraction and uses thereof
The present disclosure relates to a nutritional composition comprising a fat source that includes an enriched lipid fraction derived from milk. The enriched lipid fraction may contain saturated fatty acids, trans-fatty acids, monounsaturated fatty acids, clas, bcfas, cholesterol, milk fat globule membrane proteins, gangliosides, and mixtures thereof.
09/11/14
20140255317
Preparation comprising hexose-6-phosphate-modified cholesterol derivative
Provided is a compound represented by the general formula (1) (where: g represents a hexose-6-phosphate residue; and l represents a divalent linker group).. .
09/04/14
20140249394
Health monitoring and diagnostic device and network-based health assessment and medical records maintenance system
A health monitoring and diagnostic device (lifestream cholesterol meter) configured as a self-contained testing and diagnostic unit in a clam-shell type case. One side of the case includes a spring-loaded finger stick and a compartment for carrying one or more packages of disposable items including a test strip, a needle for the finger stick, and an alcohol swipe.
09/04/14
20140249226
Methods of administering compositions comprising docosapentaenoic acid
The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (ldl) cholesterol, non-hdl cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.. .
09/04/14
20140249225
Methods of reducing or preventing oxidative modification of membrane polyunsaturated fatty acids
In various embodiments, the present invention provides methods of treating and/or preventing cardiovascular-related disease and, in particular, a method of reducing or preventing membrane cholesterol domain formation in a subject, the method comprising administering to a subject in need thereof a pharmaceutical composition comprising eicosapentaenoic acid or a derivative thereof.. .
09/04/14
20140248653
Method for selecting mevalonate synthesis modulators using cells derived from human pluripotent cells
A method for selecting pharmaceutical compounds affecting mevalonate or cholesterol, having a step for putting into contact with the pharmaceutical compounds to be tested, cells of the msc type obtained by a method for producing cells of the msc type from human pluripotent cells or from induced stem cells, including a step for cultivating human pluripotent cells or induced stem cells in a culture medium having the steps of: 1) one or more growth factors selected from fgfs, hgf, pdgfs, egf, herugulins and vegfs, and 2) one or more antioxidants selected from ascorbic acid and its derivatives, vitamin e and n-acetylcysteine.. .
09/04/14
20140248391
Use of infant formula with large lipid globules
The invention relates to infant nutrition comprising large lipid globules. This infant nutrition has programming effects on the body and results in a reduced level of total blood cholesterol later in life when consuming a western style diet.
09/04/14
20140248304
Non-hemolytic llo fusion proteins and methods of utilizing same
The present invention provides recombinant proteins or peptides comprising a mutated listeriolysin o (llo) protein or fragment thereof, comprising a substitution or internal deletion of the cholesterol-binding domain or a portion thereof, fusion proteins or peptides comprising same, nucleotide molecules encoding same, and vaccine vectors comprising or encoding same. The present invention also provides methods of utilizing recombinant proteins, peptides, nucleotide molecules, and vaccine vectors of the present invention to induce an immune response to a peptide of interest..
08/21/14
20140235872
Novel low molecular weight cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in the liver.
08/21/14
20140235831
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235830
Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
08/21/14
20140235723
Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, alzheimer's disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, syndrome x, thrombotic disorder. Compounds and methods of the invention can also be used to modulate c reactive protein or enhance bile production in a patient.


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