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Cholesterol

Cholesterol-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Effects of apolipoprotein b inhibition on gene expression profiles in animals
Kastle Therapeutics, Llc
April 05, 2018 - N°20180094260

Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein b. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein b. Methods of using these compounds for modulation of apolipoprotein b expression and for treatment of diseases associated with expression of apolipoprotein b are provided. Methods are provided for modulating the expression ...
Compositions containing tannic acids and uses thereof
Syneurx International (taiwan) Corp.
April 05, 2018 - N°20180092935

Compositions (e. G., pharmaceutical compositions, nutraceutical compositions or medical food compositions) comprising tannic acids, particularly tannic acids which are d-amino acid oxidase inhibitor with superior potency, purity and safety profile; and uses thereof for treating cns disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.
Processes in the preparation of coconut meat based compositions and films
April 05, 2018 - N°20180092391

A dehydrated coconut meat based edible film, including its improvements and modifications, includes mainly of coconut meat wherein other fruit and vegetables are added as flavorings and enhancers. These coconut meat based films can be used as crepes, rolls, and or wraps, which are usually employed in wrapping any food such as fresh fruits, vegetables, salads, or cooked meat/fish, ...
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Anti-pcsk9 compounds and methods for the treatment and/or prevention of cardiovascular diseases
Shifa Biomedical Corporation
March 22, 2018 - N°20180079730

Disclosed are compounds that modulate the physiological action of the proprotein convertase subtilisin kexin type 9 (pcsk9), and methods of using these modulators to reduce ldl-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease (cvd), including treatment of hypercholesterolemia.
Dietary supplements containing dehydrated strawberry
March 22, 2018 - N°20180078598

Compositions and processes are disclosed for a capsule, tablet, or pill comprised of powdered strawberries. Fresh strawberries are washed, de-calyxed, and then processed into a dry pulp. The dry pulp may be pulverized to a desired granularity. In some embodiments, the pulp may be filtered to remove the seeds, prior to drying. In some embodiments the fruit may be dried ...
Fixed dose combinations and formulations comprising etc1002 and one or more statins and methods of ...
Esperion Therapeutics, Inc.
March 22, 2018 - N°20180078518

Disclosed herein are compositions comprising fixed doses of etc-1002 and one or more statins. Also disclosed herein are methods for using fixed doses of etc-1002 and one or more statins. Uses include methods of treating cardiovascular disease or reducing the risk of cardiovascular disease in a subject. Uses also include methods of treating hypercholesterolemia in a subject.
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Nanoparticles as catalytic substrates for real-time biosensing of human performance and diagnostic and therapeutic methods
Northwestern University
March 15, 2018 - N°20180074080

Nanostructures having an inorganic core and a lipid layer capable of binding a lecithin:cholesterol acyltransferase (lcat) activator such as an apolipoprotein are provided herein. Methods of using the nanostructures and related devices and compositions for assessing the risk of developing a disease or condition or treating the disease or condition are also provided.
Compositions and methods to assess the capacity of hdl to support reverse cholesterol transport
Children's Hospital & Research Center At Oakland
March 15, 2018 - N°20180074079

The invention provides compositions and methods for assessing the capacity of high density lipoprotein (hdl) to support reverse cholesterol transport in blood by measuring exchange if hdl-specific spin-labeled lipoprotein probes and electron paramagnetic spectroscopy. The invention also provides methods to identify individuals at risk for cardiovascular disease, to monitor the treatment of cardiovascular disease and in the development of therapies ...
Herbal supplement ''optimal cholesterol''
March 15, 2018 - N°20180071349

“optimal cholesterol” utilizes edible nature plant extracted by a variety of technology, it is one of the nature plant medicines which can treat atherosclerotic coronary heart disease, cerebral vascular disease and systemic vascular disease in the world. Its function is to soften the arterial blood vessels, and to treat arteriosclerosis, protect and repair the vascular endothelial ...
Polysaccharide-polyamine copolymer and use thereof in reducing low density lipolipoprotein (ldl) concentration in plasma
March 15, 2018 - N°20180071331

Disclosed is a pharmaceutical composition for treating hypercholesterolemia. The pharmaceutical composition includes a polysaccharide-polyamine copolymer and a pharmaceutically acceptable salt thereof as active ingredients. The polysaccharide-polyamine copolymer is formed by copolymerization of the following two parts: a selectively oxidized polysaccharide with 2,3-dialdehyde, and a polyamine with an amino functional group; the polyamine with an amino functional group and the selectively ...
Acetylated pcsk9
Universitat Zurich
March 08, 2018 - N°20180066070

The invention relates to antibodies reactive to acetylated pcsk9, particularly to pcsk9 acetylated in position lys421, lys273, lys69, lys83, lys243, lys258, lys494, and/or lys506, and related reagents. The invention also relates to a method of reducing ldl-cholesterol level in a patient in need thereof, said method comprising administering to the subject an effective amount of an antibody binding to ...
Products and methods using soy peptides to lower total and ldl cholesterol levels
Sl Technology, Inc.
March 08, 2018 - N°20180064783

Controlled studies demonstrate that products and related methods using soy related peptides lower total and ldl cholesterol levels in individuals. In one exemplary embodiment of the present disclosure, a product containing an effective amount of lunasin peptides that lowers cholesterol levels in an individual that consumes the lunasin peptides is provided. In another exemplary embodiment of the present disclosure, a ...
Compounds, compositions and methods useful for cholesterol mobilization
Cerenis Therapeutics Holding Sa
March 08, 2018 - N°20180064718

The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and compositions comprising the same. The invention also relates to methods for treating or preventing a disease or disorder, which comprises administering a therapeutically or prophylactically effective amount a compound described herein.
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Fixed dose combinations and formulations comprising etc1002 and ezetimibe and methods of treating or reducing ...
Esperion Therapeutics, Inc.
March 08, 2018 - N°20180064671

Disclosed herein are compositions comprising fixed doses of etc-1002 and ezetimibe. Also disclosed herein are methods for using fixed doses of etc-1002 and ezetimibe. Uses include methods of treating cardiovascular disease or reducing the risk of cardiovascular disease in a subject. Uses also include methods of treating hypercholesterolemia in a subject.
Therapeutics and methods of treating fatty liver disease
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
February 22, 2018 - N°20180051289

A method of treating a condition in a mammal comprising administering a pharmacologically effective amount of a therapeutic, wherein the therapeutic one of increases epha2 expression and supplements ephrin type-a receptor 2, and the condition is one of fatty liver disease, elevated plasma cholesterol level, and elevated plasma triglyceride level.
Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated ...
Vanderbilt University
February 22, 2018 - N°20180050083

The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a nuclear transport modifier may ...
Intestinal microbe therapy, composition therefor and method for preparing the same
Taichung Veterans General Hospital
February 22, 2018 - N°20180050069

The present invention discloses a method for treating and/or preventing metabolic syndrome and related diseases thereof, by administering a microbe composition to an individual to achieve the modulation of blood glucose, inhibition of body weight gain, reduction of low density cholesterol in blood, and reduction of hepatic expression of inflammatory factors, thereby effectively treating and/or preventing metabolic syndrome ...
Echogenic vehicle for clinical delivery of plasminogen activator and other fibrin-binding therapeutics to thrombi
Univeristy Of Cincinnati
February 15, 2018 - N°20180042841

We disclose a composition comprising an echogenic liposome (elip) having an exterior surface, an interior surface, and at least one bilayer comprising at least one lipid selected from the group consisting of saturated phospholipids, unsaturated phospholipids, mixed phospholipids, and cholesterol, and a thrombolytic compound trapped by the elip. We also disclose a method of treating a medical condition in a ...
Cardiovascular disease risk assessment
Boston Heart Diagnostic Corporation
February 08, 2018 - N°20180038877

The invention provides improved methods for analyzing cardiovascular disease risk. According to the invention, an algorithm that considers ldl and hdl subfractions, along with lp(a) provides significant improvement in predicting cvd versus standard assays that include standard risk factors. Methods of the invention comprise measuring ldl and hdl subfractions in addition to lp(a) without reference to standard risk ...
Novel low molecular weight cyclic amine containing cationic lipids for oligonucleotide delivery
Sirna Therapeutics, Inc.
February 08, 2018 - N°20180037893

The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower lipid levels in ...
Compositions and methods of altering cholesterol levels
Moderna Tx, Inc.
February 08, 2018 - N°20180036369

The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmrna molecules.
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