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Cholesterol

Cholesterol-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Preparation and uses of obeticholic acid
August 10, 2017 - N°20170226149

Or a pharmaceutically acceptable salt, solvate or amino acid conjugate thereof. Obeticholic acid is useful for the treatment or prevention of a fxr mediated disease or condition, cardiovascular disease or cholestatic liver disease, and for reducing hdl cholesterol, for lowering triglycerides in a mammal, or for inhibition of fibrosis. The present invention also relates to processes for the synthesis of ...
N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase
Universiteit Leiden
August 10, 2017 - N°20170226058

Deoxynojirimycin and deoxygalactonojirimycin derivatives according to the present invention are n-alkylated d-galacto, d-gluco- or l-ido-deoxynojirimycin with a linear methyloxypentyl group bearing various sidegroups and a non-fused bicyclic aromatic group (“x”) on the methyloxy-carbon. These compounds display an increased inhibitory potency towards gcs, and/or an increased inhibitory potency towards gba2, and/or a decreased inhibitory potency ...
Methods for reducing ldl-cholesterol
Rinat Neuroscience Corp.
August 10, 2017 - N°20170224816

The present invention relates to methods for the treatment of reducing ldl-cholesterol levels in a subject infected with hepatitis c virus (hcv) or at high risk of contracting hcv comprising administration to the subject in need thereof a therapeutically effective amount of an antagonist antibody which specifically binds to a human pcsk9 protein. The subject treatment can be used in ...
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Hydroxycholesterol immunoassay
Enzo Life Sciences, Inc. C/o Enzo Biochem, Inc.
August 03, 2017 - N°20170219612

Provided is a derivative of 22-hydroxycholesterol, 24s-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Also provided is a protein conjugated to the above derivative. Further provided is an antibody composition comprising antibodies that specifically bind to 22-hydroxycholesterol, 24s-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol. Additionally, a method of making antibodies that specifically bind to 22-hydroxycholesterol, 24s-hydroxycholesterol, 25-hydroxycholesterol, 26-hydroxycholesterol or 27-hydroxycholesterol is provided. Also, a method ...
Molecular adapter for capture and manipulation of transfer rna
The Regents Of The University Of California
August 03, 2017 - N°20170218439

The invention also encompasses novel structures and methods comprising providing a molecular adapter for capture and manipulation of transfer rna. The adaptor is bound to a trna molecule. The adaptor may be a cholesterol-linked dna adapter oligonucleotide. The invention is useful in sequencing, identification, manipulation and modification of trna.
Targeting micrornas for metabolic disorders
Eth Zurich
August 03, 2017 - N°20170218368

Provided herein are methods and compositions for the treatment of metabolic disorders. Also provided herein are methods and compositions for the reduction of blood glucose level, the reduction of gluceoneogenesis, the improvement of insulin resistance and the reduction of plasma cholesterol level. In certain embodiments, the methods comprise inhibiting the activity of mir-103. In certain embodiments, the methods comprise inhibiting ...
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[7,6]-fused bicyclic antidiabetic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217942

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Antidiabetic bicyclic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217920

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof, are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Antidiabetic bicyclic compounds
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170217918

Novel compounds of the structural formula (i), and the pharmaceutically acceptable salts thereof are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes mellitus, and of conditions that are often associated ...
Use of dehydroeburicoic acid from antrodia camphorata in the treatment or prevention of diabetes and ...
Merck Sharp & Dohme Corp.
August 03, 2017 - N°20170216384

The present invention provides a method for treating type 1 diabetes, hyperlipidemia or hepatic lipid accumulation by using dehydroeburicoic acid, as well as a method for decreasing levels of blood glucose, plasma total cholesterol, and triglyceride, and increasing insulin levels; and a method for decreasing hepatic balloon degeneration; and increasing expression levels of membrane glut4 and phospho-akt in myotubes; and enhancing ...
Drug for the treatment of cholesterol accumulation disorders, and screening method for same
Nihon Shokuhin Kako Co., Ltd.
August 03, 2017 - N°20170216342

Provided is a pharmaceutical composition for the treatment of disorders such as niemann-pick disease and gm1 gangliosidosis which are caused by the storage of cholesterol, such as lysosomal storage disease. Also provided is a method for screening for said pharmaceutical compositions that uses ips cell strains that phenocopy phentotypes of these disorders. Provided is a pharmaceutical composition for the treatment ...
Methods of treating diabetes by administering a glucagon receptor antagonist in combination with a cholesterol ...
Merch Sharp & Dohme Corp.
August 03, 2017 - N°20170216250

Use of a glucagon receptor antagonist in combination with a cholesterol absorption inhibitor for the treatment of diabetes and related conditions is disclosed.
Means and methods for diagnosing heart failure on the basis of cholesterol parameters, sphingomyelins and/...
Ruprecht-karls-universität Heidelberg
July 27, 2017 - N°20170212135

The present invention relates to diagnostic means and methods for heart failure. In particular, the invention relates to a method for diagnosing heart failure in a subject suspected to suffer therefrom comprising determining the amount of at least one cholesterol parameter and/or total sphingomyelins and/or triacylglycerols in a sample of the said subject, and comparing the amount(s) ...
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Monocyclic isoxazolines as inhibitors of cholesterol ester transfer protein
Merck Sharp & Dohme Corp.
July 27, 2017 - N°20170210715

Compounds having the structure of formula i, including pharmaceutically acceptable salts of the compounds, wherein d1, d2 and d3 are each n, ch, or substituted ch, are cetp inhibitors and are useful for raising hdl-cholesterol, reducing ldl-cholesterol, and for treating or preventing atherosclerosis.
Apoe mimetic peptides and higher potency to clear plasma cholesterol
Lipimetix Development, Llc
July 27, 2017 - N°20170209537

Disclosed are synthetic apolipoprotein e-mimicking peptides, derivatives thereof, and related peptides, which are useful as therapeutic agents for reducing plasma cholesterol; synthetic methods of making the peptides; pharmaceutical compositions comprising the peptides, and methods of treating lipid and metabolic disorders using the disclosed synthetic apolipoprotein e-mimicking peptides and compositions thereof. This abstract is intended as a scanning tool for purposes ...
Dietary supplement compositions for cardiovascular health
Melaleuca, Inc.
July 27, 2017 - N°20170209463

This document provides dietary supplements. For example, composition having a combination of ingredients useful in reducing cholesterol and improving overall cardiovascular health as well as methods for reducing cholesterol and improving overall cardiovascular health are provided.
Cell culture methods and media comprising n-acetylcysteine
Medimmune, Llc
July 20, 2017 - N°20170204362

This application provides improved cell culture media and cell culture methods comprising n-acetylcysteine. These improved cell culture media and cell culture methods increase cell viability, cellular growth rate and/or reduce cell doubling time of cholesterol auxotrophic cells, myeloma cells, and hybridoma cells.
Novel pharmaceutical compound having inhibitory activity against cholesterol acyltransferase isozyme 2 (acat2)
School Juridical Person Kitasato Institute
July 20, 2017 - N°20170204114

This invention provides a novel non-natural pharmaceutical compound having a different mechanism than statin drugs and having a selective inhibitory activity against acat2. This invention relates to the compound represented by formula (i), a salt thereof, or a solvate thereof:
Process for producing 7-dehydrocholesterol and vitamin d3
Kyowa Hakko Bio Co., Ltd.
July 20, 2017 - N°20170204056

According to the present invention, there can be provided a process for producing 7-dehydrocholesterol (7dhc), comprising culturing, in a medium, a 7dhc-producing labyrinthulea microorganism in which sterol 24-c-methyltransferase activity is reduced or lost as compared to a parent strain, allowing 7dhc to be produced and accumulated in the culture, and collecting the 7dhc from the culture; and a process for ...
Adjuvant compositions and related methods
Vaxliant, Llc
July 20, 2017 - N°20170202959

The present disclosure provides for an adjuvant composition that is suited for injectable as well as transdermal administration. The adjuvant composition generally comprises a lipophile, a polymer of acrylic or methacrylic acid, saline, cholesterol, a saponin, and sodium hydroxide. A vaccine composition is also provided for that generally includes the vaccine composition of the present disclosure and a dna component. ...
Preparation of 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof in transgenic ...
Organobalance Gmbh
July 13, 2017 - N°20170198328

The present invention relates to a method for preparing 7-dehydrocholesterol and/or the biosynthetic intermediates and/or secondary products thereof by culturing organisms, in particular yeasts. Furthermore, the invention relates to the preparation of the nucleic acid constructs required for preparing the genetically modified organisms and to said genetically modified organisms, in particular yeasts, themselves.
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