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Cholesterol patents



      
           
This page is updated frequently with new Cholesterol-related patent applications. Subscribe to the Cholesterol RSS feed to automatically get the update: related Cholesterol RSS feeds. RSS updates for this page: Cholesterol RSS RSS


Date/App# patent app List of recent Cholesterol-related patents
12/11/14
20140364416
 Compositions and methods comprising c16:1n7-palmitoleate patent thumbnailCompositions and methods comprising c16:1n7-palmitoleate
One embodiment described herein is related to methods and compositions, such as nutraceutical formulations and dietary supplements, comprising c16:1n7-palmitoleate or derivatives thereof. The methods and compositions comprising c16:1n7-palmitoleate, or derivatives thereof, safely and effectively prevent or mitigate manifestations of cardiovascular disease, including coronary artery disease and the accumulation of cholesterol or lipid deposits in the blood vessels of a subject..
12/11/14
20140364382
 Composition for inhibiting liver function deterioration, containing citrus peel extract or narirutin as active ingredient, and method for extracting narirutin from citrus peel patent thumbnailComposition for inhibiting liver function deterioration, containing citrus peel extract or narirutin as active ingredient, and method for extracting narirutin from citrus peel
The present invention relates to a pharmaceutical composition for treating liver diseases, containing a narirutin extract of citrus peel extract or narirutin as an active ingredient. The extract or narirutin decreases cholesterol levels and fat levels in liver tissue, and thus can be utilized as a composition or food for preventing and treating liver diseases.
12/11/14
20140363845
 Cholesterol-based media supplements for cell culture patent thumbnailCholesterol-based media supplements for cell culture
The disclosure provides compositions and methods for high density cell culture and banking of cholesterol auxotrophic cells.. .
12/11/14
20140363517
 Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders patent thumbnailMethods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders
This invention discloses methods of using krill oil and compositions comprising krill oil to treat risk factors for metabolic, cardiovascular, and inflammatory disorders. The present invention also relates to methods of using compositions comprising krill oil to modulate biological processes selected from the group consisting of glucose metabolism, lipid biosynthesis, fatty acid metabolism, cholesterol biosynthesis, and the mitochondria respiratory chain.
12/04/14
20140357854
 Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) patent thumbnailNucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357853
 Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) patent thumbnailNucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357852
 Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) patent thumbnailNucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357851
 Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) patent thumbnailNucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357850
 Nucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9) patent thumbnailNucleic acid encoding antigen binding proteins to proprotein convertase subtilisin kexin type 9 (pcsk9)
Antigen binding proteins that interact with proprotein convertase subtilisin kexin type 9 (pcsk9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to pcsk9 are described.
12/04/14
20140357632
 Benzopiperazine derivatives as cetp inhibitors patent thumbnailBenzopiperazine derivatives as cetp inhibitors
Compounds having the structure of formula ia, including pharmaceutically acceptable salts of the compounds, are cetp inhibitors and may be useful for raising hdl-cholesterol, reducing ldl-cholesterol, and for treating or preventing atherosclerosis.. .
12/04/14
20140356371
Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (pcsk9)
The present invention provides methods for reducing various lipoprotein fractions in the serum of patients. The methods of the invention include reducing serum remnant cholesterol, and/or the serum concentration of one or more ldl-c subfractions in a patient.
12/04/14
20140356370
Methods for treating autosomal dominant hypercholesterolemia associated with pcsk9 gain-of-function mutations
The present invention provides methods for treating autosomal dominant hypercholesterolemia (adh). According to certain embodiments, the adh is caused by or associated with a gain-of-function mutation (gofm) in a gene encoding pcsk9.
11/27/14
20140348997
Beta-cyclodextrin immobilized on glass and cholesterol removal using the same
The present disclosure relates to beta-cyclodextrin immobilized on glass manufactured by method comprising: a) synthesizing mono-6-(p-toluenesulfonyl)-6-deoxy-cyclodextrin from beta-cyclodextrin and converting the mono-6-(p-toluenesulfonyl)-6-deoxy-cyclodextrin into β-cyclodextrin-undecenyl ether; and b) etching borosilicate glass and coating the borosilicate glass with the β-cyclodextrin-undecenyl ether and removal of cholesterol from milk using the same.. .
11/27/14
20140348949
Om vitamin formula
A composition comprising various vitamins to make a multi-vitamin. The vitamins identified in multi-vitamin include vitamin b-1, vitamin b-2, niacinamide, vitamin b-6, vitamin b-12, pantothenic acid, folic acid, beta carotene, iron, biotin, choline, vitamin a, vitamin e and vitamin c.
11/20/14
20140343321
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof to modulate lipid metabolism
The invention relates to plasminogen activator-1 (pai-1) inhibitor compounds and uses thereof in the treatment of any disease or condition associated with elevated pai-1. The invention includes, but is not limited to, the use of such compounds to modulate lipid metabolism and treat conditions associated with elevated pai-1, cholesterol, or lipid levels..
11/20/14
20140341974
Liposomal vaccine adjuvants and methods of making and using same
A vaccine adjuvant composition comprising: a lipid selected from the group consisting of: dipalmitoyl phosphatidicholine (dppc), dipalmitoyl phosphatidylglycerol (dppg), dioleoyl phosphatidylcholine (dopc), and cholesterol and containing a positively or negatively charged lipid with associated/entrapped protein antigen.. .
11/13/14
20140336395
Salt forms of [r-(r*,r*)]-2-(4-fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid
Novel salt forms of [r—(r*,r*)]-2-(4-fluorophenyl)-β,δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1h-pyrrole-1-heptanoic acid characterized by their x-ray powder diffraction pattern and solid-state nmr spectra are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia, and alzheimer's disease.. .
11/13/14
20140336220
Composition for preventing or treating obesity comprising rebamipide
The present disclosure relates to a composition and a health functional food for preventing or treating obesity comprising a rebamipide compound or its pharmaceutically acceptable salt as an active component. It is confirmed that when a rebamipide compound of the present disclosure is administered to a mouse model induced with obesity, it shows excellent effects of reducing weight, reducing adipocyte, and reducing a total cholesterol content in the body, as compared with a non-administered control group, and also, it shows an excellent effect of suppressing differentiation of cytotoxic th17 cells that generate and secrets inflammatory cytokine and an excellent effect of improving activity of regulatory t cells (treg) capable of suppressing a function of abnormally activated immune cells and controlling an inflammatory reaction.
11/13/14
20140336113
Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated with metabolic syndrome
The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject.
11/13/14
20140335066
Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile
A microorganism strain lactobacillus plantarum inducia dsm 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L.
11/06/14
20140328851
Cholesterol ester transfer protein (cetp) inhibitor polypeptide antibodies for prophylactic and therapeutic anti-atherosclerosis treatments
Herein are described two antibodies that can inhibit cetp-lipoproteins interaction and cetp activity. Presently described are an antibody or fragment thereof capable of specifically binding to an epitope of the n-terminal or c-terminal domains of cetp and methods of using these antibodies for separation, identification, diagnosis and therapy..
10/30/14
20140323548
Novel amino alcohol cationic lipids for oligonucleotide delivery
The instant invention provides for novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that is more efficacious than traditional cationic lipids.
10/30/14
20140322735
Method to measure endogenous enzymatic serum/plasma cholesterol esterification by lcat (lecithin:cholesterol acyltransferase) assay
The present invention provides a method for the assessment of cholesterol esterification through physiologically relevant pathways and incorporates the function of individual subject's endogenous hdl particles. This ex vivo approach avoids the use of an artificial substrate and provides for determination of lcat activity that includes both the contribution of a subject's endogenous hdl function and endogenous lcat protein, and is therefore a significant improvement to the biologic relevance..
10/23/14
20140316124
Modidifed irna agents
The invention relates to irna agents, which preferably include a monomer in which the ribose moiety has been replaced by a moiety other than ribose. The inclusion of such a monomer can allow for modulation of a property of the irna agent into which it is incorporated, e.g., by using the non-ribose moiety as a point to which a ligand or other entity, e.g., a lipophilic moiety.
10/23/14
20140315928
Substituted amide compounds
The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as ldl-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of ldl-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.. .
10/23/14
20140315873
Animal feed including cationic cholesterol additive and related methods
Methods and feed compositions for increasing health of agricultural animals include administering a cationic cholesterol additive through the diet of the animal, such as through solid feed or drinking water of the animals. The method includes feeding an animal a diet comprised of a cationic cholesterol additive, such as a compound with a sterol backbone and a plurality of cationic groups attached thereto.
10/23/14
20140314844
Oral complex formulation comprising omega-3 fatty acid and hmg-coa reductase inhibitor with improved stability
The present invention relates to an oral complex formulation comprising omega-3 fatty acid or its derivatives encapsulated in a hard or soft capsule containing sorbitol and sorbitan, as well as an hmg-coa reductase inhibitor. The formulation of the present invention comprising omega-3 fatty acid encapsulated with sorbitol and sorbitan provides better prevention related materials from being formed, leading to improved long-term storage stability.
10/23/14
20140314729
Nutraceutical formulation for treatment of elevated cholesterol and cardiovascular disease
Disclosed are compositions of matter useful for the treatment of elevated blood cholesterol. In one embodiment a nutraceutical composition is administered to a patient in need of said composition comprising of the following combination of ingredients: policosanol, niacin, guggul, garlic, cynara scolymus, red yeast rice, ginger, holy basil, l-carnitine, chromium picolinate, coenzyme q10, pantothenic acid, grape seed extract, momordica charantia, and garcinia indica..
10/16/14
20140309295
Antiepileptic, hypocholesterolemic and neuroprotective compound
Its hydroxy acid form, the pharmaceutically acceptable salts of said hydroxy acid and pharmaceutically acceptable prodrugs and solvates of the compound and of its hydroxy acid form and, in particular, said compound, its hydroxy acid form, salts, etc. For its use in the prevention of: neurodegenerative diseases, cognitive deterioration, diseases associated with undesired oxidation, age-associated pathological processes and progeria, epilepsy, epileptic seizures and convulsions, cardiovascular diseases such as atherosclerosis, atrial fibrillation, dyslipemia, hypercholesterolemia, hyperlipidemia, and hypertriglyceridemia, or fungal or viral infections..
10/16/14
20140308340
Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases
The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of acyl-coa:cholesterol acyltransferase 1, but not acyl-coa:cholesterol acyltransferase 2.. .
10/16/14
20140308304
Lipids for the delivery of active agents
The present invention relates to novel cationic lipids that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides, to facilitate the cellular uptake and endosomal escape, and to knockdown target mrna both in vitro and in vivo. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol.
10/09/14
20140303380
Process for a cetp inhibitor
An efficient process is disclosed for producing the compound of formula i, which is the cetp inhibitor anacetrapib, which raises hdl-cholesterol and reduces ldl-cholesterol in human patients and may be effective for treating or reducing the risk of developing atherosclerosis:. .
10/09/14
20140303209
Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side-effects
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an mtp inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the mtp inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the mtp inhibitor to the subject.
10/09/14
20140302128
Biological oil composition, formulations comprising the oil composition, and use thereof to prevent or treat cardiovascular disease
This invention relates to a biological oil composition, preferably obtained from a copepod, most preferably the copepod calanus finmarchicus and the use thereof to prevent or treat formation of atherosclerotic plaques and hence development of coronary heart disease. The composition comprises the same marine n-3 polyunsaturated fatty acids (pufas) generally regarded as being responsible for the anti-atherosclerotic effect of marine oils, namely epa (c20:5n-3 eicosapentaenoic acid) and dha (c22:6n-3 docosahexaenoic acid).
10/09/14
20140301968
Antimicrobial cationic polycarbonates
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups.
10/09/14
20140301967
Antimicrobial cationic polycarbonates
Antimicrobial cationic polymers having one or two cationic polycarbonate chains were prepared by organocatalyzed ring opening polymerization. One antimicrobial cationic polymer has a polymer chain consisting essentially of cationic carbonate repeat units linked to one or two end groups.
10/02/14
20140296305
Use of quaternary pyridinium salts as vasoprotective agents
Wherein r is nh2, ch3, or n(h)ch2oh group, and x is pharmaceutically acceptable counterion, for the preparation of vasoprotective agent for the treatment or prevention of conditions or diseases associated with dysfunction of vascular endothelium, oxidative stress, and/or insufficient production of endothelial prostacyclin pgi2, in particular but not exclusively if the above coincides with hypercholesterolemia, hypertriglyceridemia or low hdl level.. .
09/25/14
20140288187
Cocoa-based food products
The invention is concerned with food products comprising one or more cocoa bean products and a carotenoid compound, particularly with food products which are, or comprise, chocolate. The products of the invention may be used in reducing elevated total cholesterol, triglycerides and inflammatory damage, as well as improving tissue microcirculation and tissue oxygenation..
09/25/14
20140288072
5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester-transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis
The present application relates to a series of substituted pyra-zolopyridin-6-amines having the general formula (i), including their stereoisomers and/or their pharmaceutically acceptable salts. Wherein r, r1, r2, ra, raa, rb and n are as defined herein.
09/25/14
20140287994
Peptides having reduced toxicity that stimulate cholesterol efflux
The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e.g., apo ai and apo e), and having high selectivity for abca1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses.
09/25/14
20140287479
Modified lecithin-cholesterol acyltransferase enzymes
The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying lcat polypeptide.. .
09/25/14
20140287128
Emulsified liquid seasoning
Provided is a low-calorie, low-cholesterol emulsified liquid seasoning in which syneresis, separation, and setting are suppressed. The emulsified liquid seasoning includes a crosslinked starch, an octenyl succinate-treated starch, and a polysaccharide thickener.
09/25/14
20140286945
Enzyme inhibitor for cancer treatment
Disclosed herein is a new and improved therapy for the treatment of diseases including cancer, which comprises the step of altering cell membrane lipid composition by treating a cancer cell with an enzyme inhibitor which inhibits enzymes regulating the cholesterol biosynthetic pathway. The method may also be employed in combination with existing chemotherapeutic agents to combat the drug resistance and enhance the therapeutic efficacy of conventional therapy..
09/18/14
20140276344
Shunting of dietary lipids including cholesterol
Methods and devices for redirecting at least a portion of a fluid from the mesenteric lymphatic system for elimination from the body are disclosed. The fluid may be redirected for elimination through the urinary system or redirected outside the body.
09/18/14
20140275227
Compositions and methods of altering cholesterol levels
The present invention relates to compositions, methods and kits using polynucleotides, primary transcripts and mmrna molecules.. .
09/18/14
20140275207
Antisense compounds and methods of use thereof
Disclosed herein are compounds, compositions and methods for modulating the expression of lmw-ptpase in a cell, tissue or animal. Also provided are methods of target validation.
09/18/14
20140274946
Method of using nutritional compounds dihydroquercetin (taxifolin) and arabinogalactan in combination with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors associated with metabolic syndrome and hypercholesterolemia
The method of using nutritional compounds including dihydroquercetin (taxifolin). Arabinogalactan and arabinogalactan combined with dihydroquercetin (taxifolin) to reduce and control cardiometabolic risk factors, associated with metabolic syndrome and hypercholesterolemia in a mammal, specifically a human, resulting in the enhancement of metabolism, reduced control levels of cholesterol and triglycerides, reduced oxidative damage in humans and other health benefits..


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This listing is a sample listing of patent applications related to Cholesterol for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Cholesterol with additional patents listed. Browse our RSS directory or Search for other possible listings.
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