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Cholesterol

Cholesterol-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for measuring bile salt export transport and/or formation activity
Biotranex, Llc
November 30, 2017 - N°20170343535

A method is provided to measure modulation of bile salt export transport and/or formation activity in hepatocyte or stable cell line preparations by test agents including but not limited to drugs, drug candidates, biologicals, food components, herb or plant components, proteins, peptides, dna, rna. Furthermore, the method is to determine modulation of bile salt export transport and/or formation ...
System and method for assessing quantities or sizes of lipoprotein particles from lipoprotein particle compositions
True Health Ip Llc
November 30, 2017 - N°20170343464

This application discloses methods for assessing quantities of spherical or substantially spherical lipoprotein particles or portions thereof present in a biological sample based on the measurement of free cholesterol and/or phospholipid content in the lipoprotein particles. Methods of treating a subject at increased risk for cardiovascular disease and/or cardiodiabetes are also disclosed.
Methods for treating hypercholesterolemia
Ionis Pharmaceuticals, Inc.
November 30, 2017 - N°20170342420

Disclosed herein are antisense compounds and methods for decreasing ldl-c in an individual having elevated ldl-c. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted ...
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Bmp inhibitors and methods of use thereof
The Cleveland Clinic Foundation
November 23, 2017 - N°20170334918

The present invention provides small molecule inhibitors of bmp signaling. These compounds may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds may ...
Composition to enhance hdl cholesterol and to decrease intima-media thickening in animals and humans and ...
Arjuna Natural Extracts, Ltd.
November 23, 2017 - N°20170333507

A method of producing a product to correct hypercholesterolemia including pulping fruits of emblica officinalis with demineralized water to create a slurry. The slurry is treated with pectinase. The pectinase-treated slurry is filtered to create a solution. The solution is concentrated to create a product. A product having an extract of emblica officinalis for prophylactic and for therapeutic treatment of ...
Probiotic strains having cholesterol absorbing capacity, methods and uses thereof
Biosearch, S.a.
November 23, 2017 - N°20170333495

The invention relates to a probiotic strain selected from lactobacillus reuteri v340 with accession number cect and bifidobacterium breve bt820 with accession number cect 8606, or a variant of said probiotic strain having cholesterol-absorbing capacity, and to methods and therapeutic uses thereof. The invention also relates to compositions, pharmaceutical compositions, feeds or nutritional products comprising a probiotic strain selected from lactobacillus ...
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Lactococcus lactis strains for producing bioactive peptides having anti-hypertensive and cholesterol-lowering effects
Centro De Investigación En Alimentación Y Desarrollo, A.c. (ciad)
November 16, 2017 - N°20170326198

New lactococcus lactis strains, nrrl b-50571 and nrrl b-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower ldl-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional ...
Methods of use to orally and topically treat acne and other skin conditions by administering ...
Wisconsin Alumni Research Foundation
November 16, 2017 - N°20170326159

Oral and topical pharmaceutical compositions, kits and methods of treatment thereof for treating various skin disorder including acne, psoriasis, ichthyosis, photoaging, photodamaged skin, and, skin cancer. Exemplary vitamin d analogs as active pharmaceutical ingredients include 2-methylene-19-nor-20(s)-1α-hydroxy-bishomopregnacalciferol, 19-nor-26,27-dimethylene-20(s)-2-methylene-1α,25-dihydroxyvitamin d3, 2-methylene-1α,25-dihydroxy-(17e)-17(20)-dehydro-19-nor-vitamin d3, 2...
Stable powder formulation containing an anticholingeric agent
Boehringer Ingelheim International Gmbh
November 16, 2017 - N°20170326150

A spray-dried powder formulation comprising particles that contain the following components i) to iii): i) anticholinergic agents, in particular at least one compound of formula 1, in which x− is a negatively charged anion, ii) at least one embedding material selected from the group consisting of mono- or disaccharides, oligosaccharides, polymers, sugar alcohols and cholesterol, and iii) an organic, physiologically ...
Measurement of serum lipoproteins
Vap Diagnostics Laboratory Inc.
November 09, 2017 - N°20170322135

Although a more accurate estimate of a person's risk of cardiovascular disease can be made on the basis of the number of lipoprotein particles per unit volume in the person's blood, current methods all rely on measuring the mass of lipoprotein cholesterol per unit volume. It has been discovered that a rapid and accurate lipoprotein particle count can be obtained ...
A dietary fibre composition
Inqpharm Group Sdn Bhd
November 09, 2017 - N°20170319616

The invention provides a composition comprising glucomannan, carrageenan, xanthan gum and a monovalent or divalent cation salt. The composition is suitable for use in managing weight, combating obesity, combating metabolic syndrome, promoting satiety, reducing appetite, combating diabetes, lowering blood cholesterol, lowering blood pressure, reducing postpranial glycaemia, or increasing insulin sensitivity.
Thyroid hormone receptor agonist and use thereof
Metabasis Therapeutics, Inc.
November 09, 2017 - N°20170319604

A thyroid hormone receptor agonist and its use in the treatment of a disease associated thyroid hormone receptor beta are described. The compound can be effective in lowering cholesterol with minimum or no adverse effects on the heart or thyroid hormone axis.
Composition
Optibiotix Limited
November 09, 2017 - N°20170318851

The present invention relates to compositions for use and formulation as weight management products and in particular fermented dairy foodstuffs. The compositions generally comprise two or more of the following components: a) a microbiome modifying component; b) a satiety modifying component; and c) a metabolic modifying 5 component and at least one of the following: d) streptococcus thermophilus cbs 139100 and lactobacillus ...
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Methods for treating patients with familial hypercholesterolemia
Optibiotix Limited
November 02, 2017 - N°20170312359

The present invention provides methods for treating patients suffering from familial hypercholesterolemia, including both hefh and hofh. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds to angptl3 in combination with a therapeutically effective amount of a ...
Use of recombinant lymphocyte activation gene-3 as a companion therapeutic for patients at risk for ...
Optibiotix Limited
November 02, 2017 - N°20170312338

A method for classifying patients at risk for cardiovascular disease, other chronic inflammatory diseases, cardiovascular and/or non-cardiovascular morbidity and mortality based on a risk assessment for lymphocyte activation gene 3 (lag3) protein deficiency, and for mediating the risk using recombinant lymphocyte activation gene-3 or lag3 mimetic as a companion therapeutic alone or in combination with a statin and/or an ...
Measurement of serum lipoproteins
Vap Diagnostics Laboratory Inc.
October 26, 2017 - N°20170307504

Although a more accurate estimate of a person's risk of cardiovascular disease can be made on the basis of the number of lipoprotein particles per unit volume in the person's blood, current methods all rely on measuring the mass of lipoprotein cholesterol per unit volume. It has been discovered that a rapid and accurate lipoprotein particle count can be obtained ...
Treatment with anti-pcsk9 antibodies
Pfizer Inc.
October 26, 2017 - N°20170306051

The present invention relates to therapeutic dosing regimens utilizing a dose reduction strategy for treating disorders characterized by marked elevations of low density protein cholesterol (ldl-c) in the plasma of a patient. The subject therapeutic dosing regimens involve delivering as a single administration or plurality of administrations of an anti-proprotein convertase subtilisin kexin type 9 (pcsk9) antagonist antibody as an initial ...
Anti-endothelial lipase compounds and methods of using the same in the treatment and/or prevention ...
Shifa Biomedical Corporation
October 26, 2017 - N°20170305887

Endothelial lipase (el) inhibitors and methods of using such inhibitors for treating conditions implicating el are provided herein. The present invention meets the needs in the field by providing small molecule inhibitors of el function that can be used therapeutically to raise hdl cholesterol levels in blood, and can be used in the prevention and/or treatment of cholesterol and ...
Compositions and methods for inhibiting bmp
University Of Houston System
October 26, 2017 - N°20170305883

The present invention provides small molecule inhibitors of bmp signaling and compositions and methods for inhibiting bmp signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as ...
Dyslipidemia therapeutic agent
Kowa Company, Ltd.
October 26, 2017 - N°20170304274

This invention provides a combination-drug composition and a combination use of pharmaceuticals for preventing and/or treating dyslipidemic conditions such as hyper-ldl cholesterolemia in mammals, including humans. This invention pertains to a drug composition for preventing and or treating dyslipidemia and the like, the drug composition including the following: (r)-2-[3-[[n-(benzoxazol-2-yl)-n-3-(4-methoxyphenoxy)propyl]...
Condensed heterocyclic compound
Kowa Company, Ltd.
October 19, 2017 - N°20170298081

A compound represented by the general formula (i) [r1 represents a c1-6 alkyl group, a halogen atom, or the like; a represents a phenylene group, or the like; x represents —ch(r3)—, —o—, —nh—, or the like; y represents —o—, —nh—, —n═, or —s—; . . . Represents ...
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