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Cholesterol

Cholesterol-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases
Trustees Of Dartmouth College
October 12, 2017 - N°20170292128

The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of acyl-coa: cholesterol acyltransferase 1, but not acyl-coa: cholesterol acyltransferase 2.
Methods for treating hyperlipidemia with an angptl8 inhibitor and an angptl3 inhibitor
Regeneron Pharmaceuticals, Inc.
October 12, 2017 - N°20170291937

The present invention provides methods for treating patients suffering from hyperlipidaemia, wherein the patient is non-responsive to, inadequately controlled by, or intolerant to treatment with a standard lipid modifying therapy. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that ...
Plasminogen activator inhibitor-1 inhibitors and methods of use thereof
Eastern Michigan University
October 12, 2017 - N°20170291893

The invention relates to plasminogen activator-1 (pai-1) inhibitor compounds and uses thereof in the treatment of any disease or disorder associated with elevated pai-1. The invention includes, but is not limited to, the use of such compounds to prevent or reduce thrombosis and fibrosis, to promote thrombolysis, and to modulate lipid metabolism and treat diseases or disorders associated with elevated ...
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Treatment of male androgen deficiency symptoms or diseases with sex steroid precursor combined with serm
Endorecherche, Inc.
October 12, 2017 - N°20170290847

Novel methods for prevention, reduction or elimination of the incidence of male androgen deficiency symptoms or diseases including male hypogonadism-associated symptoms and diseases associated with low serum testosterone and/or low dhea or low total androgens in susceptible warm-blooded animals including humans involving administration of an amount of a sex steroid precursor, particularly dehydroepiandrosterone (dhea) and a selective estrogen receptor ...
Peptides having reduced toxicity that stimulate cholesterol efflux
The Regents Of The University Of California
October 05, 2017 - N°20170283480

The present invention provides a family of non-naturally occurring polypeptides having cholesterol efflux activity that parallels that of full-length apolipoproteins (e. G., apo ai and apo e), and having high selectivity for abca1 that parallels that of full-length apolipoproteins. Further, the peptides of the invention have little or no toxicity when administered at therapeutic and higher doses. The invention also ...
A method for side effect reduction in the use of statins via physiologically synthesized glutathione
The Regents Of The University Of California
October 05, 2017 - N°20170281713

Embodiments of the present invention relate generally the use of certain compositions, e. G., compositions comprising a glutathione precursor and a selenium source, in the therapy of subjects suffering from diseases associated with hyperiipidemia and/or hypercholesterolemia. Related embodiments of the present invention relate to treatment and/or reducing the incidence of the side effects of statin therapy comprising administering ...
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Use of dihydrocholesterol
Nestec S.a.
October 05, 2017 - N°20170281650

The use of dihydrocholesterol (dhc) in low doses of up to 50 mg per kg of body weight to treat or prevention excess weight or obesity and/or hyperlipidemia, and/or a disorders associated with any of the foregoing, and a composition comprising dhc.
Fused heterocyclic organic compounds and uses thereof
Perlstein Lab Pbc
October 05, 2017 - N°20170281635

This disclosure provides compounds, pharmaceutical formulations, and related methods of use for the treatment of defects of cholesterol homeostasis including lysosomal storage disorders such as niemann-pick type c disease.
Isoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170275274

The present invention relates to a compound represented by formula i: and pharmaceutically acceptable salts thereof. The compounds of formula i are inhibitors of diacylglyceride o-acyltransferase 2 (“dgat2”) and may be useful in the treatment, prevention and suppression of diseases mediated by dgat2. The compounds of the present invention may be useful in the treatment of hepatic ...
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170273966

The present invention relates to a compound represented by formula i:and pharmaceutically acceptable salts thereof. The compounds of formula i are inhibitors of diacylglyceride o-acyltransferase 2 (“dgat2”) and may be useful in the treatment, prevention and suppression of diseases mediated by dgat2. The compounds of the present invention may be useful in the treatment of hepatic ...
Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride o-acyltransferase 2
Merck Sharp & Dohme Corp.
September 28, 2017 - N°20170273965

The present invention relates to a compound represented by formula (i): and pharmaceutically acceptable salts thereof. The compounds of formula (i) are inhibitors of diacylglyceride o-acyltransferase 2 (“dgat2”) and may be useful in the treatment, prevention and suppression of diseases mediated by dgat2. The compounds of the present invention may be useful in the treatment of hepatic ...
Composition for preventing the occurrence of cardiovascular event in multiple risk patient
Mochida Pharmaceutical Co., Ltd.
September 28, 2017 - N°20170273928

Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with hmg-coa ri or a cardiovascular event occurring in a multiple risk patient.
Process for preparing synthetic intermediates for preparing tetrahydroquinoline derivatives
Dezima Pharma B.v.
September 21, 2017 - N°20170267640

The present invention relates to a process for the preparation of synthetic intermediates which may be used in the preparation of tetrahydroquinoline derivatives, which derivatives have an inhibitory activity against cholesteryl transfer protein (cetp), show effects of increasing hdl cholesterol level and decreasing ldl cholesterol level, and can be used for the treatment and/or prevention of diseases such as ...
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Squalene compounds as modulators of ldl-receptor expression
The Research Foundation For The State University Of New York
September 14, 2017 - N°20170260126

Wherein m, r1, n, r2 and r3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with elevated levels of low density lipoprotein cholesterol (ldl-c).
Human lung tissues-active targeting immune nanoliposome of methylprednisolone and a method for producing the same
Shanghai Pulmonary Hospital
September 14, 2017 - N°20170258811

Present invention relates to a human lung tissues-active targeting immune nanoliposome of methylprednisolone, wherein, nanoliposomes loaded with therapy drugs is covalently coupled with nanobodies against human pulmonary surfactant protein a. Wherein, the therapy drug is methylprednisolone sodium succinate, the nanoliposome consists of phospholipids, cholesterols and long cycling materials. The molar ratio of the methylprednisolone sodium succinate to phospholipids within the ...
Methods for treating disorders or diseases associated with hyperlipidemia and hypercholesterolemia while minimizing side effects
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170258776

The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an mtp inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the mtp inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages ...
Methods for treating patients with hyperlipidemia by administering a pcsk9 inhibitor in combination with an ...
Regeneron Pharmaceuticals, Inc.
September 07, 2017 - N°20170253666

The present invention provides methods for treating patients suffering from hypercholesterolemia, wherein the patient is non-responsive to, inadequately controlled by, or intolerant to treatment with a standard lipid modifying therapy. The methods of the invention provide for lowering at least one lipid parameter in the patient by administering a therapeutically effective amount of an antibody or antigen-binding fragment thereof that ...
Oxygenated cholesterol sulfates for therapy of disorders caused by at least one of attenuated leptin ...
Virginia Commonwealth University
September 07, 2017 - N°20170252355

Methods and compositions are provided for the prevention and/or treatment of symptoms associated with lipid accumulation disorders caused by attenuated leptin activity and by lipid storage disorders. The methods involve administering at least one oxygenated cholesterol sulfate (ocs) to a subject with the disorder. The disorder may be acquired or congenital (hereditary).
Medicine
Kowa Company, Ltd.
September 07, 2017 - N°20170252338

A medicine for lowering ldl cholesterol is provided. A medicine for lowering ldl cholesterol, the medicine comprising a combination of a statin and (s)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl)phenyl]ethyl}{5-[2-(methylsulfonyl) ethoxy]pyrimidin-2-yl}amino)methyl]-4-(trifluoromethyl)phenyl}(ethyl)amino)methyl]cyclohexyl}acetic acid, a salt thereof, or a solvate of the compound or ...
Composition and methods of use of small molecules as binding ligands for the modulation of ...
Srx Cardio, Llc
August 31, 2017 - N°20170246196

This invention is related to the field of pcsk9 biology and the composition and methods of use of small molecule ligands for modulation of pcsk9 biological activity. In particular, the invention provides compositions of small molecule compounds that modulate circulating levels of low density lipoproteins by altering the conformation of the protein pcsk9. Binding these small molecule ligands to pcsk9 ...
Treatment of patients with homozygous familial hypercholesterolemia on lipid lowering therapy
Gemphire Therapeutics Inc.
August 31, 2017 - N°20170246133

Methods for the treatment of homozygous familial hypercholesterolemia by administering gemcabene as an adjunct to other lipid lowering therapy and/or modified diet.
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