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Cholesterol

Cholesterol-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Esculentin-2cha peptide and analogues thereof
University Of Ulster
June 15, 2017 - N°20170166614

The present invention relates to an esculentin-2cha peptide and analogues thereof, and the use each thereof in the treatment of diabetes, for example type 2 diabetes; insulin resistance; obesity, and/or hypercholesterolemia. Also disclosed is a pharmaceutical composition comprising peptides and analogues according to the present invention; use of peptides and analogues according to the present invention for the manufacture ...
Antidiabetic substituted heteroaryl compounds
Merck Sharp & Dohme Corp.
June 15, 2017 - N°20170166578

The present invention relates to a compound represented by formula (i): and pharmaceutically acceptable salts thereof. The compounds of formula i are agonists of g-protein coupled receptor 40 (gpr40) and may be useful in the treatment, prevention and suppression of diseases mediated by the g-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of type 2 diabetes ...
Novel synthesis of potential ester prodrugs
Merck Sharp & Dohme Corp.
June 15, 2017 - N°20170165371

Esters prodrugs that cross the blood brain barrier can be ideal drugs for treatment of diseases of the central nervous system because the cerebral spinal fluid contains an abundance of esterases. The prodrug can be hydrolyzed into an active drug and a metabolite such as cholesterol that is known to be non-toxic and is familiar to the central nervous system. ...
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Method of synthesizing 25-hydroxy cholesterol
Hangzhou Xiasha Biochemical Tech Co., Ltd
June 08, 2017 - N°20170158729

The present invention discloses a method for synthesizing 25-hydroxy cholesterol. The method is as below: subjecting 24-dehydrocholesterol derivative as a raw material, which undergoes an addition reaction with a hydroxyl containing reagent in an organic solvent under catalysis, and then hydrolyzing the reaction product and separating to obtain 25-hydroxy cholesterol. The present invention adopts hydroxyl containing reagents such as water, ...
Composition for preventing the occurrence of cardiovascular event in multiple risk patient
Mochida Pharmaceutical Co., Ltd.
June 01, 2017 - N°20170151206

Disclosed is a composition which is useful for preventing the occurrence of a cardiovascular event, particularly a composition which is expected to show a prophylactic effect on a cardiovascular event occurring in a hypercholesterolemia patient despite providing the patient with a treatment with hmg-coa ri or a cardiovascular event occurring in a multiple risk patient.
Methods of lowering proprotein convertase subtilisin/kexin type 9 (pcsk9)
Mochida Pharmaceutical Co., Ltd.
May 25, 2017 - N°20170144972

The invention relates to new methods of modulating cholesterol by inhibiting proprotein convertase subtilisin/kexin type 9 (pcsk9) with fatty acid derivatives; and new methods for treating or preventing a metabolic disease comprising the administration of an effective amount of a fatty acid derivative. The present invention is also directed to fatty acid bioative derivatives and their use in the treatment ...
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Cellulose-adipate-#-cyclodextrin structure, and preparation method therefor
Mochida Pharmaceutical Co., Ltd.
May 25, 2017 - N°20170143016

The present invention relates to a structure composed of β-cyclodextrin, a linker and a supporter, and a preparation method thereof. The cellulose-adipate-β-cyclodextrin structure of the present invention is effective in removing cholesterol from foods, and the use of the cellulose-adipate-β-cyclodextrin structure may reduce the onset of adult and chronic diseases due to ...
Organic compositions to treat apoc3-related diseases
Arrowhead Pharmaceuticals, Inc.
May 18, 2017 - N°20170137814

The present disclosure relates to compositions and methods for treating apoc3-related diseases such as: hypertriglyceridemia (e. G., type v hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a rnai agent to apoc3.
Sulfated-oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver tissue regeneration
Virginia Commonwealth University
May 18, 2017 - N°20170136038

Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25hc3s) to the subject e. G. By 1) administering 25hc3s to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme sult2b1b, which catalyzes the sulfation ...
Pharmaceutical compositions of berberine with epa and dha, and methods thereof
Shenzhen Hightide Biopharmaceutical, Ltd.
May 18, 2017 - N°20170135995

The invention provides various novel compositions of berberine in combination with pharmacologically active epa and dha, and related methods of their use in treating various diseases or disorders. The pharmaceutical compositions of the invention are useful in treating and/or preventing various diseases or disorders, including metabolic diseases or disorders such as dyslipidemia, hyperglycemia, hypertriglyceridemia, hyperlipidemia, diabetic dyslipidemia, diabetic hyperlipidemia, ...
Novel diester and triester based low molecular weight, biodegradeable cationic lipids for oligonucleotide delivery
Sirna Therapeutics, Inc.
May 18, 2017 - N°20170135962

The instant invention provides for novel cationic lipids of formula a that can be used in combination with other lipid components such as cholesterol and peg-lipids to form lipid nanoparticles with oligonucleotides. It is an object of the instant invention to provide a cationic lipid scaffold that demonstrates enhanced efficacy along with lower liver toxicity as a result of lower ...
Agents and mechanisms for treating hypercholesterolemia
Sirna Therapeutics, Inc.
May 18, 2017 - N°20170135391

A method of treating hypercholesterolemia in mammals, by administering an effective amount of a microbial fermentation product, and regulating genes involved in lipoprotein metabolism. A method of regulating cholesterol levels in a patient by administering an effective amount of a composition chosen from the group consisting of paz, specific components isolated from paz, chemically synthesized analogues of the components of ...
Method for expecting and diagnosing uqcrb-related disease
Industry-academic Cooperation Foundation, Yonsei University
May 11, 2017 - N°20170130270

Disclosed is a method for expecting and diagnosing uqcrb-related disease, and more particularly, related to a method for diagnosing a uqcrb-related disease and a cholesterol biosynthesis related disease, as well as expecting risks of post-occurrence of the uqcrb-related disease and the cholesterol biosynthesis related disease, simply by measuring an expression level of mirna, and a kit and a biomarker composition ...
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Ppar modulators
FundaÇao Universidade De BrasÍlia
May 04, 2017 - N°20170121268

The present application relates to amorfrutin analogs and uses as ppar modulators for the treatment of metabolic syndrome, obesity, hyperlipidemia, elevated fasting blood glucose, elevated blood pressure, low hdl cholesterol, type 2 diabetes, cardiovascular disease, a neurodegenerative disease, malaria or irritable bowel syndrome.
Pharmaceutical compositions for substituted quinazolinones
Resverlogix Corp.
May 04, 2017 - N°20170119767

The present disclosure relates to novel solid pharmaceutical formulations and process for their preparation. The present disclosure also provides, in part, methods of using the pharmaceutical formulations for regulating the expression of apolipoprotein a-i (apoa-i), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.
Method for analyzing lipoproteins
Resverlogix Corp.
April 27, 2017 - N°20170115316

A concentration of cholesterol ester or free cholesterol can be calculated using the concentrations of total cholesterol and triglyceride in lipoproteins contained in a sample. Further, a concentration of lipoprotein particles in a fraction can be calculated using the lipoprotein particle size in the fraction. The concentrations of total cholesterol and triglyceride contained in a subject sample are detected. Using ...
Portable, rapid, and inexpensive diagnostic tests for cardiac disease risk
Resverlogix Corp.
April 27, 2017 - N°20170115228

Cardiac disease is the world's leading cause of death. Cardiac disease's pathogenesis is largely attributed to cholesterol, predominantly carried by low-density lipoproteins (ldl). However, recent research has found that oxidized-ldl is significantly more potent in the initiation and development of atherosclerosis. Tests for both cholesterol and ox-ldl tests are lab-based and expensive. With every third american at risk for cardiac ...
Cyclohexene derivative, preparation method therefor, and pharmaceutical composition for preventing or treating metabolic diseases, containing ...
Hyundai Pharm Co., Ltd.
April 27, 2017 - N°20170114072

The present invention relates to: a cyclohexene derivative; a preparation method therefor; and a pharmaceutical composition for preventing or treating metabolic diseases, containing the same as an active ingredient. The cyclohexene derivative according to the present invention increases the intracellular activity of cyclic adenosine monophosphate (camp) by activating g protein-coupled receptor 119 (gpr-119) and simultaneously exhibits weight loss and hypoglycemic effects ...
Benzamide or benzamine compounds useful as anticancer agents for the treatment of human cancers
The Board Of Regents Of The University Of Texas System
April 27, 2017 - N°20170114062

The described invention provides small molecule anti-cancer compounds for treating tumors that respond to cholesterol biosynthesis inhibition. The compounds selectively inhibit the cholesterol biosynthetic pathway in tumor-derived cancer cells, but do not affect normally dividing cells.
Therapeutic agent for dyslipidemia
Kowa Company, Ltd.
April 27, 2017 - N°20170112811

The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low hdl blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc. Which comprises (a) a compound represented by the general formula (1) (in the ...
Disease management systems comprising dietary supplements
Kowa Company, Ltd.
April 20, 2017 - N°20170109499

Described herein are integrated programs and systems that manage or treat chronic conditions such as elevated cholesterol or elevated blood pressure and other health conditions. The integrated system may include a combination of: a dietary supplement; behavior change messaging through packaging (including use of unit dose packaging) and/or package inserts; video content available through the web or mobile means; ...
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