 Patent Application Title |
Patent App Num. |
Date |
| Assay system for determining binding of hydrophobic drugs | 20120100634 | 20120426 |
| The invention comprises a method for the determination of the binding coefficient of a hydrophobic chemical compound comprising: g. Providing an assay plate with a plurality of rows and columns of test vessels; h. Providing the majority of the test vessels in said assay plate with a polymer, wherein in each row the amount of polymer coating per test vessel is increased; i. Filling each test vessel with a solution of binding partner to which the binding coefficient should be assayed, wherein in each column the amount of binding partner is increased; j. Adding the hydrophobic compound and incubate the plate; k. Determining the concentration of said compound in said polymer or in the solution; l. Calculating the protein binding coefficient of the compound.
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| Test strip for h. pylori detection | 20120094371 | 20120419 |
| A test device, including: a compartment defining an environment and comprising a specimen region; an indicator medium disposed in the compartment; a separation medium disposed in the compartment between the specimen region and the indicator medium; an active ingredient adjacent the specimen region; and a color indicator disposed on the indicator medium and responsive a chemical compound produced by a reaction involving the active ingredient by changing from a first color to a second color. The separation medium is configured to permit fluid communication directly between the environment and a side of the indicator medium proximate the separation medium when the separation medium and the indicator medium abut each other.
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| Method for increasing the vigor and/or crop yield of agricultural plants under essentially non-existent pathogen pressure | 20120094834 | 20120419 |
| J) insecticides.
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| Process for inhibiting unwanted free-radical polymerization of acrylic acid present in a liquid phase p | 20120085969 | 20120412 |
| A process for inhibiting unwanted free-radical polymerization of acrylic acid present in a liquid phase P whose acrylic acid content is at least 10% by weight and which, based on the weight of the acrylic acid present therein, additionally comprises at least 100 ppm by weight of propionic acid and at least 100 ppm by weight of glyoxal, in which at least one chemical compound of the element copper is added to the liquid phase P, and the resulting liquid phases P to which a chemical compound of the element copper has been added.
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| Stabilization of chemical compounds using nanoparticulate formulations | 20120087984 | 20120412 |
| Methods for stabilizing chemical compounds, particularly pharmaceutical agents, using nanoparticulate compositions are described. The nanoparticulate compositions comprise a chemical compound, such as a pharmaceutical agent, and at least one surface stabilizer. The component chemical compound exhibits chemical stability, even following prolonged storage, repeated freezing-thawing cycles, exposure to elevated temperatures, or exposure to non-physiological pH conditions.
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| Chemical coating compound for protecting glassy surfaces exposed to the external environment | 20120070643 | 20120322 |
| A Coating chemical compound for protecting glassy surfaces exposed to the external environment comprising silicon dioxide, in percentage between about 0.3÷2% approximately, isopropyl alcohol (2-propanol) in percentage between 60÷70% approximately, 1-methoxy-2-propanol in percentage between 15÷25% approximately, ethanol in percentage between 0.5-3.5% approximately and ethyl silicate in percentage between 0.1÷1% approximately.
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| Aqueous particulate slurry compositions and methods of making same | 20120071371 | 20120322 |
| A sand slurry composition and a method for making sand slurries are disclosed. The sand slurry composition is comprised of sand, an aqueous liquid and a chemical compound that renders the surface sand of hydrophobic. The method is comprised of rendering sand surface hydrophobic during or before making the slurry. This method and composition can find many applications in different industries, especially in various oil field applications.
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| Methods and apparatuses for dilute phase impregnation of a milled sorbent with a chemical compound in an aqueous solution | 20120058885 | 20120308 |
| The present disclosure relates to apparatus designed to impregnate a sorbent. In some embodiments apparatus of the disclosure may comprise a mixing vessel having either a conical mixing chamber or an cylindrical mixing chamber designed to increase the contact surface area and/or contact/residence time of a sorbent and impregnant to produce compositions comprising an impregnated sorbent. Apparatus of the disclosure may also comprise one or more atomizers operable to produce atomized droplets of impregnant. The disclosure also provides methods for impregnation of a milled sorbent or an un-milled sorbent. Methods of the disclosure provide several technical advantages and may be cost effective. Impregnant sorbent compositions produced by methods and/or apparatus of the disclosure may have higher concentrations of an impregnant, a more uniform distribution of an... |
| All-solid battery | 20120052396 | 20120301 |
| An all-solid battery includes: a positive electrode active material layer that includes a positive electrode active material; a negative electrode active material layer that includes a negative electrode active material; and a solid electrolyte layer that is formed between the positive electrode active material layer and the negative electrode active material layer. The positive electrode active material layer or the solid electrolyte layer further includes a solid electrolyte material. A reaction suppressing portion is formed at an interface between the positive electrode active material and the solid electrolyte material. The reaction suppressing portion is a chemical compound that includes a cation portion formed of a metal element and a polyanion portion formed of a central element that forms covalent bonds with a plurality of oxygen elements.
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| Spherical radiofrequency-encoded beads | 20120041111 | 20120216 |
| The invention relates to a method for the production of a composition comprising a plurality of spherical radiofrequency-identifiable (RF-tagged) polymeric beads as well the composition as such. The invention also relates to an apparatus for analyzing, identifying or sorting as well as treating a plurality of spherical radiofrequency-identifiable beads, and further to a method for recording individual reaction steps involved in the step-wise synthesis of a chemical compound on a radiofrequency-detectable bead. The beads of the composition are substantial spherical and preferably comprises a hydrophilic polymer material so as to prevent fouling.
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| Inorganic oxide powder. | 20120031801 | 20120209 |
| A chemical compound of Black Iron Oxide particles coated with aluminum oxide particles and magnesium sulfate particles. The coated compound is protected from contact with the oxygen molecules in the surrounding atmosphere and thereby is less prone to self-heating and combustion.
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| Processing method | 20120034395 | 20120209 |
| A processing method includes disposing a workpiece having a processed surface in a processing solution, disposing a photocatalyst film in the processing solution opposite the processed surface, irradiating the photocatalyst film with a light, so as to generate active species from the processing solution by a photocatalytic action of the photocatalyst film, controlling a diffusion distance of the active species in the processing solution by a radical scavenger added to the processing solution, and chemically reacting the active species with surface atoms of the processed surface and generating a chemical compound to be eluted in the processing solution, so as to process the workpiece.
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| Drug releasing coatings for medical devices | 20120035530 | 20120209 |
| The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from... |
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| Drug releasing coatings for medical devices | 20120029426 | 20120202 |
| The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from... |
| Small molecule printing | 20120021933 | 20120126 |
| The present invention provides compositions and methods to facilitate the identification of compounds that are capable of interacting with a biological macromolecule of interest. In one aspect, a composition is provided that comprises an array of one or more types of chemical compounds attached to a solid support, wherein the density of the array of compounds is at least 1000 spots per cm2. In particularly preferred embodiments, these compounds are attached to the solid support through a covalent interaction. In general, these inventive arrays are generated by: (1) providing a solid support, wherein said solid support is functionalized with a selected chemical moiety capable of interacting with a desired chemical compound to form an attachment; (2) providing one or more solutions of one or more types... |
| Method for forming electrodynamic machine insulated coils | 20120011708 | 20120119 |
| A method for manufacturing electrodynamic machine conductive coils, such as alternating current induction motor stator coils. A continuous strand of insulation coated wire is formed into a generally planar elongated closed loop having a circumference and an outer surface. Thereafter a permanent insulation layer is applied to the closed loop outer surface, preferably by spiral wrapping insulating tape about the circumference of the closed loop with a tape wrapping machine. The insulating tape has a catalytic chemical compound including at least one part of a multi-part epoxy resin. The closed loop is shaped into a rigid conductive coil by application pressure, in order to conform the coil to a desired profile. Application of the permanent insulation layer to the closed loop prior to its final shaping... |
| Rotation member, housing, bearing, gearbox, rotating machine, shaft structure and surface treatment method | 20120009357 | 20120112 |
| In a rotation member rotatably engaged with a housing, a pulsing electric discharge is generated in a processing liquid or in a gas, between an electrode and the rotation member. The electrode is a chemical compound of a metallic powder or metal, or a molded body formed by molding ceramic powder, or a molded body obtained by heating the molded body. Energy from the electric discharges causes coating to be formed on an engagement portion engaging the housing, the coating formed from the material of the electrode or a substance to which the electrode material combined by the energy of the electric discharges.
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| Label-free high throughput biomolecular screening system and method | 20120010105 | 20120112 |
| A screening system and method are described herein which provide a unique and practical solution for enabling label-free high throughput screening (HTS) to aid in the discovery of new drugs. In one embodiment, the screening system enables direct binding assays to be performed in which a biomolecular interaction of a chemical compound (drug candidate) with a biomolecule (therapeutic target) can be detected using assay volumes and concentrations that are compatible with the current practices of HTS in the pharmaceutical industry. The screening system also enables the detection of bio-chemical interactions that occur in the wells of a microplate which incorporates biosensors and surface chemistry to immobilize the therapeutic target at the surface of the biosensors. The screening system also includes fluid handling and plate handling devices... |
| Method and device for producing a fuel containing carbon | 20110314735 | 20111229 |
| The invention relates to a method for producing a fuel (10) containing carbon, wherein the fuel (10) is formed by compressing raw material (2) containing carbon and adding an additive (4) that promotes thermal utilization of the fuel at a specified amount, and the additive (4) contains a chemical compound made of the elements calcium and/or magnesium and having or not having carbon. According to the invention, in a first method step, the raw material (2) containing carbon is pressed and in this way a pressed fuel article (6) is produced, and then the additive (4) is fed to at least one area (6a) of said pressed fuel article (6).
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| Chemical bath deposition apparatuses and fabrication methods for chemical compound thin films | 20110318493 | 20111229 |
| Chemical bath deposition (CBD) apparatuses and fabrication methods for compound thin films are presented. A chemical bath deposition apparatus includes a chemical bath reaction container, a substrate chuck for fixing a substrate arranged face-down toward the bottom of the chemical bath reaction container, multiple solution containers connecting to a reaction solution mixer and further connection to the chemical bath reaction container, and a temperature control system including a first heater controlling the temperature of the chemical bath reaction container, a second heater controlling the temperature of the substrate chuck, and a third heater controlling the temperature of the multiple solution containers.
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| Encoded self-assembling chemical libraries (esachel) | 20110319278 | 20111229 |
| The invention concerns a chemical compound comprising a chemical moiety (p) capable of performing a binding interaction with a target molecule (e.g. a biological target) and further comprising an oligonucleotide (b) or functional analogue thereof. In a first embodiment according to the invention, the chemical compound is characterized in that the oligonucleotide (b) or functional analogue comprises at least one self-assembly sequence (b1) capable of performing a combination reaction with at least one self-assembly sequence (b1′) of a complementary oligonucleotide or functional analogue bound to another chemical compound comprising a chemical moiety (q). In a second embodiment according to the invention, the chemical compound which comprises a coding sequence (b1) coding for the identification of the chemical moiety (p) is characterized in that the chemical compound... |
| Methods and materials for the detection of melamine | 20110294220 | 20111201 |
| Methods and materials for the detection of melamine in test samples such as foodstuffs are described. Embodiments of the invention comprise combining a test sample suspected of containing melamine with a particle that produces a colorimetric and/or turbidimetric signal that is dependent upon the concentration of melamine in the test sample. In certain embodiments of the invention, the particles and test sample are combined together with a chemical compound selected to induce the aggregation melamine in a manner that amplifies the colorimetric and/or turbidimetric signal of the assay. In some embodiments of the invention, the aggregation inducing agent is not physically coupled to the particles used in the assays. In other embodiments of the invention, the aggregation inducing agent is physically coupled to the particles used... |
| Valves having high wear-resistance and high corrosion-resistance | 20110278490 | 20111117 |
| The invention provides a valve which suppresses a continuous corrosion of a chemical compound phase such as an eutectic carbide or the like in a valve seat, and improves a corrosion resistance, an impact resistance and an erosion resistance of the valve seat. The invention disperses a chemical compound phase such as the eutectic carbide or the like crystallizing in a dendrite gap as a granular shape or a blocky shape which is equal to or less than about 100 μm, by moving a tool rotating in a crimped state by a load application to a vertical direction to a surface of the valve seat so as to carry out a friction stir processing, and forming a weld metallographic structure of a surface layer portion of... |
| Microfeature workpieces having conductive interconnect structures formed by chemically reactive processes, and associated systems and methods | 20110256711 | 20111020 |
| Microfeature workpieces having conductive vias formed by chemically reactive processes, and associated systems and methods are disclosed. A method in accordance with one embodiment includes disposing a conductive lining on walls of a via in a microfeature workpiece, so that a space is located between opposing portions of the lining facing toward each other from opposing portions of the wall. The method can further include chemically reacting the lining with a reactive material to form a chemical compound from a constituent of the reactive material and a constituent of the lining. The method can still further include at least partially filling the space with the compound. In particular embodiments, the conductive lining includes copper, the reactive material includes sulfur hexafluoride, and the chemical compound that at... |
| Chemical sensors containing carbon nanotubes, method for making same, and uses therof | 20110244585 | 20111006 |
| A device is disclosed for detecting at least one chemical compound comprising at least one carbon nanotube with several graphene layers, on which is grafted at least one molecule bearing group G1 capable of reacting with the chemical compound or a precursor of such a group G1. The uses and the method of making such a device is also disclosed.
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| Method for loading a monomer to a bulk container | 20110182675 | 20110728 |
| This application is directed to a method for minimizing oxidative discoloration of a chemical compound such as a monomer during shipping, storing, and/or aging.
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| Substrate cleaning method and substrate cleaning apparatus | 20110168205 | 20110714 |
| A substrate cleaning method performing cleaning of a surface of a substrate after a pattern on the substrate is formed by plasma etching, includes: a by-product removal process removing a by-product by exposing the substrate to an HF gas atmosphere; and a residual fluorine removal process removing fluorine remaining on the substrate by turning cleaning gas containing hydrogen gas and chemical compound gas containing carbon and hydrogen as constituent elements into plasma to act on the substrate.
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| Photosensitive self-assembled monolayer for selective placement of hydrophilic structures | 20110165428 | 20110707 |
| A photosensitive monolayer is self-assembled on an oxide surface. The chemical compound of the photosensitive monolayer has three components. A first end group provides covalent bonds with the oxide surface for self assembly on the oxide surface. A photosensitive group that dissociates upon exposure to ultraviolet radiation is linked to the first end group. A second end group linked to the photosensitive group provides hydrophobicity. Upon exposure to the ultraviolet radiation, the dissociated photosensitive group is cleaved and forms a hydrophilic derivative in the exposed region, rendering the exposed region hydrophilic. Carbon nanotubes or nanocrystals applied in an aqueous dispersion are selectively attracted to the hydrophilic exposed region to from electrostatic bonding with the hydrophilic surface of the cleaved photosensitive group.
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| Electrochemical sensor utilising a dual redox system contained within a single molecule | 20110162977 | 20110707 |
| An electrochemical sensor utilises a chemical compound which is not a macromolecule but rather is a single chemical compound of determinate structure, incorporating two redox systems which differ in their response to a species to be detected. In one form, one redox system displays a voltammetric wave which is pH dependent while another displays a voltammetric wave which is pH independent and acts as an internal reference. The sensor comprises a solid substrate, which may be carbonaceous, on which the compound is immobilized. The sensor may be incorporated into a tool to be suspended in a wellbore.
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| Drug releasing coatings for medical devices | 20110160660 | 20110630 |
| The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In embodiments, the additive is water-soluble. In further embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has a molecular weight of from... |
| Electron absorber layer | 20110014484 | 20110120 |
| In a method for applying an electron absorber layer to a substrate, an electron absorber layer is produced from a composite material, by coating the substrate with a metallic material, and material inclusions made from an additional material are embedded in the metallic material during coating. The metallic material contains aluminum, magnesium, cobalt, iron, chromium, titanium, nickel, copper, or an alloy or mixture thereof. The additional material contains one or more of the following substances: boron, carbon or silicon, a mixture of these elements, one or more chemical compounds made from or having at least two of these elements, or a mixture of such chemical compounds.
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| Method of coding information in a dual fashion on physical media and in dotem computerised form | 20110012975 | 20110120 |
| DOTEM is an information-coding method which is used to represent same on physical media with the aid of dots and in a computerised format, in memory and on networks with bits. The method is based on the broad concept of characters grouped into alphabets. The characters comprise dots on documents, for example, and bits in machine format. The physical characters have specific dots that are not represented in machine format in order to enable same to be located on media, such as the foot of a character and the head of a character. Each character can represent at least the 256 values of an octet. The character concept is extended such that it can be identified by the value thereof and, such that it can be... |
| Novel soluble 1,4 benzodiazepine compounds and stable salts thereof | 20110009393 | 20110113 |
| The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and related compounds and methods of using benzodiazepine derivatives and related compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, and the like.
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| Chemical compounds | 20110009261 | 20110113 |
| A compound of the formula (I) where, for example, W, X and Y are each CH; R1 and R6 together with the adjacent nitrogen forms a 3 to 10-membered saturated ring, wherein the ring may contain, in addition to the nitrogen and carbon ring members, 1, 2 or 3 heteroatoms and/or heteroatom groups as ring members, independently of one another, selected from the group consisting of sulfur, CO, SO, SO2 and N—R7 and/or the ring may carry 1, 2 or 3 radicals, independently of one another, each selected, for example, from the group consisting of halogen, cyano, nitro, amino, and C1-C6-alkyl. R2 is, for example, halogen, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy or C1-C6-alkoxy-C1-C6-alkoxy, and R7 is for example, R10C(═O), C1-C6 alkyl or C1-C6-haloalkyl; and/or salts thereof; and... |
| Toxicity screening methods | 20110008823 | 20110113 |
| The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of determining a level of toxicity in normal tissue for an anti-tumor compound. The methods include providing at least one cell type and culturing the cell type in the presence of at least one concentration of the chemical compound, measuring at least one indicator of cell health at the at least one concentration of compound for the at least one cell type, and performing a concentration response analysis, from which a toxic concentration can be determined.
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| Composition related to rapid elisa process | 20110008807 | 20110113 |
| The present invention provides improved and rapid detection methods for an antigen such as a chemical compound, a peptide, a nucleic acid, or a protein released from cells or virus particles in situ. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can particularly be used, for example, to modify and reduce the detection time significantly in traditional ELISA, and also Western blot or Dot blot assays. The improved ELISA method is rapid, economical, reproducible, simple and automatable. Also provided are compositions and kits for using the improved ELISA methods for the rapid detection of antigens.
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| Electrochemical dispensing apparatus and method | 20110008744 | 20110113 |
| The disclosed invention provides electrochemical dispensing apparatus and methods. According to the principles of the invention, a microelectronic electrochemical dispenser is used to cause the release of one or more selected chemical substance from a stored chemical compound. The release is controlled using a timer or sensor apparatus in a controlling device, preferably an ASIC.
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| Uses of chemicals to modulate gsk-3 signaling for treatment of bipolar disorder and other brain disorders | 20110008468 | 20110113 |
| Aspects of this invention are related, at least in part, to the use of chemical compounds able to inhibit GSK-3 and/or to stabilize β-catenin and formulations thereof. Some aspects of this invention relate to compositions comprising such compounds. Some aspects of the invention provide methods of using such compounds and/or compositions in the treatment of subjects having a neurological disease and/or psychiatric disorder. Some aspects of this invention provide methods of using ruboxistaurin, enzastaurin, sunitinib, midostaurin, lestaurtinib, 7-hydroxystaurosporine, and/or Chir99021 in the treatment of subjects having a neurological disease and/or psychiatric disorder. In some embodiments, compounds are administered in combination with Lithium.
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| Contrast agents | 20110008263 | 20110113 |
| The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CO—CH3)—X—N(CO—CH3)—R and salts or optical active isomers thereof, wherein X denotes a C3 to C4 straight or branched alkylene moiety wherein the alkylene moiety is substituted by one or two hydroxyl groups, optionally hydroxylated alkyl groups and/or alkoxy groups; and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
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| Method for predicting respiratory toxicity of compounds | 20110004414 | 20110106 |
| The invention provides methods for analyzing and predicting the in vivo respiratory toxicity of a compound (e.g., pharmaceutical, biological, cosmetic, or chemical compounds) or composition comprising a combination of an in vitro mammalian cell model with multiple endpoint analysis, and time and concentration response curves. The methods allow the determination of a predicted in vivo respiratory toxicity value of a compound without the use of animals, with a high degree of accuracy. The methods comprise detecting any combination of cell viability markers and expression levels of genes implicated in respiratory toxicity and/or sensitization, such as pro-inflammatory response genes, combining the viability and gene expression level data with concentration response and time response data, conducting a computational analysis, and comparing test compound data to a database of... |
| Anticoagulant compounds, pharmaceutical compositions on their basis to treat thrombotic conditions, and plasma-substituting solution to correct hypercoagulation defects of hemodilution | 20110003826 | 20110106 |
| This invention relates to new chemical compounds, application of these compounds as anticoagulants, pharmaceutical compositions, and plasma-substituting solutions on their basis, and can be used for treating thromboembolic complications of diseases such as myocardial infarction, stroke, and thrombosis of deep veins or a pulmonary artery; and for preventing hypercoagulation conditions in consequence of injuries, surgeries, sepsis, various obstetric pathologies, in disaster medicine, resuscitation, and so on.
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| Composition and process for preparing curable organofluorine-modified polysilazanes, and polysilazanes prepared thereby | 20100331498 | 20101230 |
| The curable organofluorine-modified polysilazanes can be prepared by combining the components of the composition and allowing or inducing the components to react.
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| Surface treatment process and treated article | 20100331487 | 20101230 |
| A surface treatment process comprises (a) providing at least one substrate having at least one major surface; (b) combining (1) at least one curable oligomeric or polymeric polysilazane comprising at least one chemically reactive site, and (2) at least one fluorochemical compound comprising (i) at least one organofluorine or heteroorganofluorine moiety that comprises at least about six perfluorinated carbon atoms, and (ii) at least one functional group that is capable of reacting with the polysilazane through at least one of the chemically reactive sites; (c) allowing or inducing the polysilazane and the fluorochemical compound to react to form at least one curable organofluorine-modified polysilazane; (d) applying the curable organofluorine-modified polysilazane or its precursors to at least a portion of at least one major surface of the... |
| Methods and compositions for treating bacterial infection | 20100331351 | 20101230 |
| The present invention relates to chemical compounds, methods for their discovery, and their therapeutic and research use. In particular, the present invention provides compounds as therapeutic agents against bacterial infections.
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| Chemical compounds 785 | 20100324068 | 20101223 |
| Z is carboxy or —CONHSO2Me or —CONRbRc wherein Rb and Rc are independently selected, for example, from hydrogen and (1-4C)alkyl or Rb and Rc are linked so as to form a morpholine ring or a (4-6C)heterocyclic ring and when Z is —CONRbRc the Rb and Rc groups may be optionally substituted by carboxy.
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| thrombin function compounds and pharmaceutical compositions based on them | 20100324058 | 20101223 |
| This invention relates to new chemical compounds, application of these compound as thrombin inhibitors, and pharmaceutical compositions based on them, and can be used to treat and prevent thrombin-dependent thromboembolic events, and in research.
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| Pharmaceutical compositions for preventing and treating eye pathologies | 20100323992 | 20101223 |
| The present invention relates to pharmacology, medicine, opthalmology, and, in particular, concerns a class of chemical compounds of structure (I) and also their solvates, isomers or prodrugs applicable when incorporated into pharmaceutical compositions also containing pharmaceutically acceptable carrier which can be useful for prophylaxis and treatment of different eye pathologies such as cataract and macular dystrophy.
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| Contrast agents | 20100322868 | 20101223 |
| The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula R—N(CHO)—X—N(R3)—R wherein X denoted an optionally substituted alkylene group, R3 denotes a hydrogen atom or an acyl function and each R denotes a triiodinated phenyl residue further substituted by hydrophilic moieties. The invention also relates to the use of such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging, and to contrast media containing such compounds.
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| Method and device for detection and identification of gases | 20100314548 | 20101216 |
| These methods and associated devices for the detection and identification of gases are used to identify and detect chemical compounds, in particular explosive and/or unhealthy substances or compounds, which must be detected in very small concentrations.
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| Chemical compounds | 20100311582 | 20101209 |
| A compound of the formula (I) where, for example, W, X and Y are each CH; R1 and R6, independently of each other, are for example, selected from the group consisting of H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl, C1-C6-alkoxy, C3-C8-cycloalkyl, R7C(═O), and a ring system; provided that at least one of R1 and R6 is a —C2-C6-alkenylthio-C1-C6-alkyl, —C1-C6-alkoxy-C(═O)NRx-C1-C6-alkyl, —partially or fully unsaturated ring system containing in at least one ring in the ring system at least one hetero atom selected from N, O and S, which ring system is bound (i.e. through the N bonded to R1 and R6 in formula I) either directly or via a a C1-C6-alkylene group to the remainder of the compound, —partially or fully unsaturated ring system containing a ring that is bound... |
| Method and apparatus providing analytical device and operating method based on solid state image sensor | 20100311182 | 20101209 |
| An analytical system-on-a-chip can be used as an analytical imaging device, for example, for detecting the presence of a chemical compound. A layer of analytical material is formed on a transparent layer overlying a solid state image sensor. The analytical material can react in known ways with at least one reactant to block light or to allow light to pass through to the array. The underlying sensor array, in turn, can process the presence, absence or amount of light into a digitized signal output. The system-on-a-chip may also include software that can detect and analyze the output signals of the device.
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| Chemical compounds | 20100305351 | 20101202 |
| where Het is a 5- or 6-membered heterocyclic ring containing one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, the ring being substituted by groups R7, R8 and R9; R1 is hydrogen, optionally substituted (C1-4alkyl, optionally substituted (C1-4alkylC(═O), optionally substituted (C1-4alkylC(═O)O, optionally substituted (C1-4)alkoxy(C1-4)alkyl, optionally substituted allyl, optionally substituted propargyl or optionally substituted allenyl; R2, R3, R4 and R5 are each, independently, hydrogen, halogen, optionally substituted (C1-4)alkyl, optionally substituted (C1-4)alkoxy or optionally substituted (C1-4)alkoxy(C1-4alkyl; R6 is an organic group containing three to thirteen carbon atoms and at least one silicon atom and, optionally, one to three heteroatoms, each independently selected from oxygen, nitrogen and sulphur, and is optionally substituted by one to four independently selected halogen atoms; R7, R8 and R9 are each,... |
| Method for preparing an inorganic crystalline ceramic material having an organized structure | 20100304154 | 20101202 |
| (c) subjecting the nanoparticles obtained in step (b) to a treatment which enables the formation of a bond between at least two nanoparticles, whereby the bond is formed directly or indirectly between the second reactive moieties of the covalenty bonded molecules of the chemical compound as obtained in step (b), thereby forming an organized structure.
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| Contrast agents | 20100303734 | 20101202 |
| The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing two linked iodinated phenyl groups of the general formula (I): R—CO—N(R)—X—N(R)—CO—R and salts or optical active isomers thereof, wherein one R denotes a hydrogen atom or a C1 to C5 straight or branched alkyl group optionally substituted by 1 to 4 —OH groups, and the other R1 denotes a C1 to C5 straight or branched alkyl group substituted by 1 to 4 —OH groups; X denotes an alkylene moiety with 3 to 10 carbon atoms substituted by 1 to 6 OH groups and where up to 3 carbon atoms optionally are replaced by... |
| Coating of organic and inorganic pigments with acrylic resins | 20100298472 | 20101125 |
| Coating of organic and inorganic pigments with acrylic resins, comprising a chemical compound consisting of particles of solid organic and inorganic substances, both defined as pigments, in that they are substances which absorb a fraction of the light and reflect the complementary part thereof, coated with acrylic and, optionally, aldehyde and/or ketone resins. The latter are deposited on the surface of the pigment by means of a process which envisages melting of the resin, consequent wetting and coating of the entire surface of the pigment with the resin in the melted state, the consequent cooling and subsequent step of grinding by means of mechanical systems operating in temperature conditions lower than 20° C., by means of cryogenic processes or granulate by means of a wet method... |
| Technical task performance techniques | 20100293040 | 20101118 |
| One form of the present invention includes a computer network, an input device, and a computer server. The computer server is coupled to the network and input device, and is programmed to present a publicly accessible description over the network. This description includes a reward offer contingent on acceptable development of a technical task. The computer server is responsive to input from the input device to alter the description when it is determined that the task has been acceptably performed. In a further form, the task involves production of a chemical compound sample and chemical analysis equipment is included to evaluate the sample.
... |
| Low molecular weight quaternary ammonium salt dispersants | 20100292467 | 20101118 |
| wherein R1 is an all group, aryl group, alkylaryl group or arylalkyl group with at least 23 carbon atoms, R2 is an alkylene group, arylene group, alkyarylene group or arylalkylene group with at least 2 carbons and X is a quaternary ammonium salt.
... |
| Chemical compounds 751 | 20100292222 | 20101118 |
| wherein, R1, R2, R3, R4, R5, X1, X2, Y, k, m, n and p are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the treatment of androgen-receptor associated conditions, particularly prostate cancer.
... |
| Functionalized fluorescent nanocrystal compositions and methods for their preparation | 20100291702 | 20101118 |
| The present invention provides for functionalized fluorescent nanocrystal compositions and methods for making these compositions. The compositions are fluorescent nanocrystals coated with at least one material. The coating material has chemical compounds or ligands with functional groups or moieties with conjugated electrons and moieties for imparting solubility to coated fluorescent nanocrystals in aqueous solutions. The coating material provides for functionalized fluorescent nanocrystal compositions which are water soluble, chemically stable, and emit light with a high quantum yield and/or luminescence efficiency when excited with light. The coating material may also have chemical compounds or ligands with moieties for bonding to target molecules and cells as well as moieties for cross-linking the coating. In the presence of reagents suitable for reacting to form capping layers, the compounds in... |
| Compressor unit and assembly method | 20100290896 | 20101118 |
| The invention relates to a compressor unit, in particular, for submarine application, comprising an electric motor. The transported medium for compression, in particular, natural gas for transport, not only frequently contains various aggressive chemical compounds but is also carrier of various condensates which hinder compression and in particular lead to increased wear of the compressor. On assembly aggressive sea water can also enter the compressor unit. The invention provides a solution to the above, wherein the rotation axis is arranged vertically during operation and the housing comprises a drain at the lower axial end. The invention further relates to an assembly method for a compressor unit, in which the compressor unit is filed above water with an incompressible fluid, transported to a submarine operating position, connectors... |
| Formulations containing pyridazine compounds | 20090325973 | 20091231 |
| are independently hydrogen, hydroxyl, alkyl, alkenyl, alkynyl, alkylene, alkenylene, alkoxy, alkenyloxy, cycloalkyl, cycloalkenyl, cycloalkynyl, cycloalkoxy, aryl, aryloxy, arylalkoxy, aroyl, heteroaryl, heterocyclic, acyl, acyloxy, amino, imino, azido, thiol, thioalkyl, thioalkoxy, thioaryl, nitro, cyano, halo, sulfate, sulfenyl, sulfinyl, sulfonyl, sulfonate, sulfoxide, silyl, silyloxy, silylalkyl, silylthio, ═O, ═S, phosphonate, ureido, carboxyl, carbonyl, carbamoyl, or carboxamide; and X is optionally substituted pyrimidinyl or pyridazinyl, an isomer, a pharmaceutically acceptable salt, or derivative thereof. The invention additional relates to compositions comprising the compounds, and methods of using the compounds and compositions for modulation of cellular pathways, for treatment or prevention of inflammatory diseases, for research, drug screening, and therapeutic applications.
... |
| Emulsion composition | 20090325806 | 20091231 |
| There is provided an emulsion composition useful as a preparation containing an active agrochemical compound. The emulsion composition essentially consisting of 0.5 to 25% by weight of one or a plurality of hydrophobic active agrochemical compounds; 5 to 15% by weight of one or a plurality of surfactants; 2 to 60% by weight of one or a plurality of aromatic hydrocarbon solvents; 2 to 60% by weight of diethyl oxalate; 12 to 90% by weight of 1,3-dimethyl-2-imidazolidinone; and 0 to 5% by weight of one or a plurality of formulation auxiliaries, wherein a weight ratio of 1,3-dimethyl-2-imidazolidinone and the aromatic hydrocarbon solvent(s) is 1:0.03 to 1:2.0, and a weight ratio of 1,3-dimethyl-2-imidazolidinone and diethyl oxalate is 1:0.03 to 1:2.0.
... |
| Method for producing platinum nanoparticles | 20090325795 | 20091231 |
| A producing method includes a preparing step of preparing a chemical compound having at least one of elements of alkali metals and alkali earth metals along with platinum, and a reducing step of reducing the prepared chemical compound with a reducing agent to form platinum nanoparticles.
... |
| Chemical compounds | 20090318477 | 20091224 |
| The present invention relates to novel compounds that are useful in the treatment of metabolic disorders, particularly Type II diabetes mellitus and related disorders, and also to the methods for the making and use of such compounds.
... |
| Aromachemicals and processes for preparation | 20090317529 | 20091224 |
| wherein R1 is H, C(O)O—CH2—CH3; C(O)O—CH3, or C(O)O—H; R2 is methyl; R3 and R4 are H; R5 and R6 are CH3; Z is C(H)2; and X is —CN. The double bond attached to X can be in the E or Z configuration.
... |
| Benzimidazole as cooling compounds | 20090312384 | 20091217 |
| in which R1, R2 are independently in either the meta- or para-position and independently comprise at least one of hydrogen, halide, C1-C3 alkyl (linear or branched), halide, C1-C3 alkoxy, nitro, nitrile, amide or ester; R3 comprises at least one of C1-C5 alkyl or C1-C5 alkenyl groups (linear or branched), R4 comprises at least one of hydrogen, C1-C3 alkyl (linear or branched), or a halide. The cooling effect provided is in some instances superior to that achievable by any of the known commercial cooling agents.
... |
| Chemical compounds | 20090312372 | 20091217 |
| wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
... |
| Noninvasive measurement of carotenoids in biological tissue | 20090306521 | 20091210 |
| A method and apparatus are provided for the determination of carotenoid antioxidants and similar chemical compounds in biological tissue such as living skin. The method and apparatus provide a noninvasive, rapid, accurate, and safe determination of carotenoid levels which in turn can provide diagnostic information of the antioxidant status of tissue. Reflection spectroscopy is used to measure the concentrations of carotenoids and similar substances in tissue. White light is directed upon the area of tissue that is of interest. A small fraction of diffusively scattered light is collected and measured. The tissue is pressured to temporarily squeeze blood out of the measured tissue volume while the reflection spectrum is continuously monitored, displayed, and analyzed in near real time. After an optimal time period of typically 15... |
| Topical pharmaceutical formulations containing a low concentration of benzoyl peroxide in suspension in water and a water-miscible organic solvent | 20090306172 | 20091210 |
| An aqueous formulation for topical application to the skin comprising water, a water-miscible organic solvent, and benzoyl peroxide, wherein the concentration of the organic solvent is sufficient to provide a stable suspension of benzoyl peroxide in the aqueous formulation without the inclusion of a surfactant in the formulation, wherein the ratio of concentrations of water and organic solvent in the formulation is sufficient to maintain the benzoyl peroxide in saturated solubility in the formulation following application to the skin, and wherein the concentration of benzoyl peroxide in the formulation is less than 5.0% and at least 1.0% w/w. The formulation may further contain a chemical compound in addition to benzoyl peroxide that is effective in the treatment of acne. The aqueous formulations of the invention are... |
| Chemical compounds | 20090306075 | 20091210 |
| wherein variable groups are defined within; their use in the inhibition of 11βHSD1, processes for making them and pharmaceutical compositions comprising them are described.
... |
| Compounds and methods for modulating the silencing of a polynucleotide of interest | 20090306035 | 20091210 |
| Methods and compositions comprising chemical compounds that modulate the silencing of a polynucleotide of interest in a cell are provided. Such chemical compounds when used in combination with an appropriate silencing element can be used to modulate (increase or decrease) the level of the polynucleotide targeted by the silencing element. Methods of using such compositions both in therapies involving RNAi-mediated suppression of gene expression, as well as, in vitro methods that allow for the targeted modulation of expression of a polynucleotide of interest are provided. Pharmaceutical or cosmetic formulations comprising such compounds and silencing elements also are disclosed. Methods for screening a compound of interest for the ability to modulate the activity of a heterologous silencing element also are provided.
... |
| Method for predicting skin sensitizing activity of compounds | 20090305276 | 20091210 |
| The present invention provides methods for predicting the in vivo skin sensitizing activity of chemical compounds using a combination of mammalian cell models with multiple endpoint analysis, time and concentration response curves. The methods allow the determination of a predicted in vivo sensitization value of a compound—for example, a EC3 LLNA value, a GPMT value or a IVTI value—without the use of animals, with a high degree of accuracy. The methods involve detecting expression levels of genes implicated in skin sensitization, combining expression level data with concentration response data, conducting a computational analysis, and comparing test compound data to a database of known skin sensitizers.
... |
| Inorganic compounds | 20090302267 | 20091210 |
| The invention relates to a chemical compound of the formula NibM1cM2d(O)x(OH)y, wherein M1 denotes at least one element from the group consisting of Fe, Co, Mg, Zn, Cu and/or mixtures thereof, M2 denotes at least one element from the group consisting of Mn, Al, B, Ca, Cr and/or mixtures thereof, wherein b≦0.8, c≦0.5, d≦0.5, and x is a number between 0.1 and 0.8, y is a number between 1.2 and 1.9, and x+y=2. A process for the preparation thereof, and the use thereof as a precursor for the preparation of cathode material for secondary lithium batteries are described.
... |
| Silicon wafer | 20090297426 | 20091203 |
| When a monocrystal is pulled up, an additive element such as boron is added to a molten silicon, and a pulling-up condition is such that a solid solution oxygen concentration is equal to or higher than 2×1018 atoms/cm3 and a chemical compound precipitation area of silicon and the additive element is formed.
... |
| Direct amination of hydrocarbons | 20090292144 | 20091126 |
| A process for aminating hydrocarbons with ammonia, which comprises performing the amination in the presence of an additive which reacts with hydrogen, the additive used being at least one organic chemical compound, N2O, hydroxylamine, hydrazine and/or carbon monoxide.
... |
| Activation method for lithium hydride, and hydrogen generation method | 20090291040 | 20091126 |
| A lithium hydride activation method includes: a nitrification treatment process of reacting lithium hydride with a nitride and therefore forming a chemical compound layer stable to the nitride, on a surface of the lithium hydride; and a particle size reduction process of reducing a particle size of the lithium hydride provided with the chemical compound layer by a mechanical pulverization treatment after the nitrification treatment process is performed. A hydrogen generation method includes generating hydrogen by reacting ammonia with the lithium hydride activated by the activation method.
... |
| Volatile chemical substance catching device and electronic apparatus | 20090290897 | 20091126 |
| A color multifunction printer of the present invention includes a volatile chemical substance catching device, provided in an exhaust duct provided above a fixing unit, which generates an electric field in an atmosphere with use of an electric-field generating and catching member, which attracts volatile chemical substances contained in the atmosphere to a surface of the electric-field generating and catching member by the action of the electric field, and which catches the volatile chemical substances. This makes it possible to realize a volatile chemical substance catching device and an electronic apparatus that hardly suffer from aged deterioration in performance and can catch volatile chemical compounds such as VOCs and odors over a long period of time.
... |
| Antiviral composition | 20090286757 | 20091119 |
| Chemical compounds, being the alkyl sulfate of sulfated saccharides, particularly, dextrin, dextran, and cyclodextrin, and pharmaceutical compositions containing these compounds. The compounds of the invention provide antiviral activity, particularly in the treatment and prevention of sexually-transmitted diseases. Methods of treating viral infection and preventing viral transmission include administration include administration of the compounds of the invention orally, topically, subcutaneously, by muscular injection, by intraperitoneal injection and by intravenous injection.
... |
| Method of removing metals from hydrocarbon feedstock using esters of carboxylic acids | 20090283449 | 20091119 |
| Method of removing metals from hydrocarbon feedstock using esters of carboxylic acids, and additives for the same, are provided, wherein hydrocarbon stream such as crude oil containing metals and slats thereof, such as calcium and calcium naphthenate, is mixed with an effective metal-removing-amount of an aqueous extraction-solution of non-precipitating and non-fouling additive comprising a chemical compound selected from a group consisting of methyl or ethyl or propyl or isopropyl mono- and/or di-esters of any of three carboxylic acids, such as, maleic acid, maleic anhydride, or fumaric acid or an appropriate combination of said esters, or an appropriate combination of any of said esters with any of said three acids, enabling formation of a hydrocarbonous phase and an aqueous phase containing the metal ions; and separating aqueous... |
| Indole antiviral compositions and methods | 20090281052 | 20091112 |
| The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
... |
| Methods for use of a sensitive layer for hydrogen sulphide detection with saw/baw devices | 20090280031 | 20091112 |
| Methods can be adapted for design of a sensitive monolayer for detection of hydrogen sulphide at room temperature with SAW/BAW devices. The sensitive monolayer can be synthesized based on chemical compounds, which belongs to a class of thiacalix[n]arenas, mercapto halides, mercapto alcohols and chloromethylated thiacalix[n]arenas. The sensitive monolayer can be directly immobilized or anchored at the surface of a piezoelectric quartz substrate in a covalently bonded manner by means of direct printing process. The piezoelectric quartz substrate can be activated in basic medium or in acid medium before the immobilization of the sensitive monolayer in order to increase the population of OH groups. Thus, the synthesized sensitive monolayer exhibits a high site density, fast response and long-term stability for H2S sensing.
... |
| Printed circuit board and manufacturing method thereof | 20090277674 | 20091112 |
| A printed circuit board and a manufacturing method thereof are disclosed. The method of manufacturing a printed circuit board can include: forming surface roughness on an insulation layer, coating a chemical compound onto the insulation layer that lowers the surface energy of the insulation layer, and forming a circuit pattern by inkjet printing on the insulation layer coated with the chemical compound. Certain embodiments of the invention can be utilized to improve adhesive strength between the insulation layer and the inkjet-printed circuit patterns, suppress spreading in the inkjet-printed circuit patterns to improve resolution, and reduce manufacturing costs by forming the circuits using inkjet printing.
... |
| Indole antiviral compositions and methods | 20090281052 | 20091112 |
| The present invention provides novel chemical compounds, and methods for their use. In particular, the present invention provides indole derivatives (e.g. as shown in Formula (I)) and related compounds and methods of using indole derivatives and related compounds as therapeutic agents to treat a number of conditions, including those associated with viral infection and cardiovascular diseases.
... |
| Methods for use of a sensitive layer for hydrogen sulphide detection with saw/baw devices | 20090280031 | 20091112 |
| Methods can be adapted for design of a sensitive monolayer for detection of hydrogen sulphide at room temperature with SAW/BAW devices. The sensitive monolayer can be synthesized based on chemical compounds, which belongs to a class of thiacalix[n]arenas, mercapto halides, mercapto alcohols and chloromethylated thiacalix[n]arenas. The sensitive monolayer can be directly immobilized or anchored at the surface of a piezoelectric quartz substrate in a covalently bonded manner by means of direct printing process. The piezoelectric quartz substrate can be activated in basic medium or in acid medium before the immobilization of the sensitive monolayer in order to increase the population of OH groups. Thus, the synthesized sensitive monolayer exhibits a high site density, fast response and long-term stability for H2S sensing.
... |
| Printed circuit board and manufacturing method thereof | 20090277674 | 20091112 |
| A printed circuit board and a manufacturing method thereof are disclosed. The method of manufacturing a printed circuit board can include: forming surface roughness on an insulation layer, coating a chemical compound onto the insulation layer that lowers the surface energy of the insulation layer, and forming a circuit pattern by inkjet printing on the insulation layer coated with the chemical compound. Certain embodiments of the invention can be utilized to improve adhesive strength between the insulation layer and the inkjet-printed circuit patterns, suppress spreading in the inkjet-printed circuit patterns to improve resolution, and reduce manufacturing costs by forming the circuits using inkjet printing.
... |
| Method and chemical agent for reduction of water production from oil and gas containing wells | 20090275489 | 20091105 |
| Method and agent for reducing water production from oil and gas wells. The agent comprises polymer, cross-linked particles which are stable in water-free solvents. The particles are manufactured in an oil-in-oil emulsion and are cross-linked with at least one water-stable cross-liner and at least one water-labile cross-linker. The water-labile cross-linker is chosen so that when it is opened or broken in a reaction with water a hydrophilic seat is formed which increases the particle's ability to swell in water. The particles furthermore comprise a controlled amount of an immobilized chemical compound which by means of said reaction between water and reactive groups in the polymer skeleton, become able to form chemical bonds to another particle, to another reactive seat in the same particle or to another... |
| Methods and compositions for treating diseases and conditions associated with mitochondrial function | 20090275099 | 20091105 |
| The present invention relates to chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides compounds as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, hyperproliferation, mitochondrial F1F0 ATP hydrolase associated disorders, and the like.
... |
| In vitro bio-reactor circuit | 20090275072 | 20091105 |
| Embodiments of the invention provide bio-reactor circuits for in vitro research applications. One embodiment provides a bio-reactor circuit comprising at least one bio-reactor and a pump fluidically coupled to the at-least-one bio-reactor. The bio-reactor comprises a housing having inlet and outlet ports and first and second chambers. The chambers are separated by a porous membrane with the first chamber providing a flow path for a fluid. The membrane includes a coating having a cell binding affinity for the attachment and proliferation of cells to cover the surface of the membrane. The second chamber provides a volume for maintaining the viability of cells disposed in the chamber. The cells can be selected to produce a biochemical compound. The membrane is configured to allow for diffusion of the... |
| Growth factor sensitive vesicle | 20090274751 | 20091105 |
| A generally spherical growth factor sensitive vesicle bearing growth factor receptors (12) having chemical compounds (14) covalently cross-linked to their non-growth factor binding domains. The chemical compounds are capable of associating to form larger chemical compounds (16) capable of destabilizing the vesicle. Methods for treating growth factor-overexpressing neoplasms are disclosed.
... |
| Method and chemical agent for reduction of water production from oil and gas containing wells | 20090275489 | 20091105 |
| Method and agent for reducing water production from oil and gas wells. The agent comprises polymer, cross-linked particles which are stable in water-free solvents. The particles are manufactured in an oil-in-oil emulsion and are cross-linked with at least one water-stable cross-liner and at least one water-labile cross-linker. The water-labile cross-linker is chosen so that when it is opened or broken in a reaction with water a hydrophilic seat is formed which increases the particle's ability to swell in water. The particles furthermore comprise a controlled amount of an immobilized chemical compound which by means of said reaction between water and reactive groups in the polymer skeleton, become able to form chemical bonds to another particle, to another reactive seat in the same particle or to another... |
| Color-encoding and in-situ interrogation of matrix-coupled chemical compounds | 20080318211 | 20081225 |
| Disclosed is a method for the physico-chemical encoding of a collection of beaded resin (“beads”) allowing determination of the chemical identity of bead-anchored compounds, following identification of beads bearing compounds of interest in an assay, by in-situ interrogation of individual beads, which does not require isolation of the beads of interest. These methods can be used to implement color-coding strategies in applications and including the ultrahigh-throughput screening of bead-based combinatorial compounds libraries as well as multiplexed diagnostic and environmental testing and other biochemical assays.
... |
| Pyridazine compounds, compositions and methods | 20080318899 | 20081225 |
| The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.
... |
| Chemical compounds | 20080318968 | 20081225 |
| wherein R1, R2, R3, n, A and HET-1 are as described in the specification, which may be useful in the treatment or prevention of a disease or medical condition mediated through glucokinase (GLK) such as type 2 diabetes. The invention also relates to pharmaceutical compositions comprising said compounds, methods of treatment of diseases mediated by GLK using said compounds and methods for preparing compounds of Formula (I).
... |
| Cyclic amine compound and pest control agent | 20080319003 | 20081225 |
| a salt, an N-oxide of the chemical compound represented by formula [I], and a pest control agent containing the formula [I] as its active constituent.
... |
| Method of high-throughput screening of molecules and compounds for their effects on biological and chemical processes | 20080311589 | 20081218 |
| The present invention provides a system for high-throughput analysis of chemical compounds. Assays are performed in a high density platform, and compounds having pre-determined desirable effects are identified. Preferably, the compounds have biological effects, more preferably, the assays and detection are performed on whole cells.
... |
| Rapid elisa processes and related compositions | 20080311602 | 20081218 |
| The present invention provides improved and rapid detection methods for an antigen such as a chemical compound, a peptide, a nucleic acid, or a protein released from cells or virus particles in situ. The detection time for an antigen can be dramatically reduced relative to conventional technologies. The technology can particularly be used, for example, to modify and reduce the detection time significantly in traditional ELISA, and also Western blot or Dot blot assays. The improved ELISA method is rapid, economical, reproducible, simple and automatable. Also provided are compositions and kits for using the improved ELISA methods for the rapid detection of antigens.
... |
| Chemical compounds-149 | 20080312206 | 20081218 |
| The invention relates to chemical compounds, or pharmaceutically acceptable salts thereof of the formula which possess CSF 1R kinase inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
... |
| Kmup-1 capable of treating hypertension | 20080312249 | 20081218 |
| A pharmaceutical composition for treating the hypertension is provided. The pharmaceutical composition comprises a chemical compound of 7-[2-[4-(2-Chlorobenzene)piperazinyl]ethyl]-1,3-dimethyl xanthine and one of a pharmaceutical acceptable salt thereof and a solvate thereof, wherein the chemical compound treats the hypertension by cGMP-dependent inhibition on Rho kinase.
... |
| Method and device for the preparation of a template to make a prototype for jewelry | 20080303188 | 20081211 |
| A jewelry template made from chemical compounds to form a polyurethane substance that hardens in stages enabling the prototype to be inserted while the mixture is malleable and thereafter removed when the template is hard. A simple and efficient method of removing the prototype from the template.
... |
| Method of hardening titanium and titanium alloys | 20080304998 | 20081211 |
| A method of hardening the outer surface of a titanium or titanium alloy substrate under standard atmospheric conditions. The method comprises focusing an electromagnetic beam from a laser generating apparatus, absent the disposition of a chemical compound, onto at least a portion of the substrate to heat it to a point below the melting point of the substrate. The treated substrate has a substantial increased harness and durability compared to an untreated surface of titanium or titanium alloy.
... |
| Quinazoline derivatives, process for their preparation and their use as anti-cancer agents | 20080306096 | 20081211 |
| The invention relates to chemical compounds of the formula (I) or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
... |
| Methods and compositions for nerve regeneration | 20080299135 | 20081204 |
| Methods and compositions for modulating growth of a neuron with a Wnt, a Wnt-like substance, and/or a chemical compound affecting a Wnt signaling pathway are disclosed. Also disclosed are methods for identifying a substance that modulates growth of a neuron by obtaining a candidate substance and contacting the candidate substance with the neuron are disclosed and methods for modulating growth of a neuron in a subject using a Wnt, a Wnt-like substance, and/or a chemical compound affecting a Wnt signaling pathway. The Wnt, Wnt-like substance, and/or chemical compounds affecting a Wnt signaling pathway can be delivered to the subject using gene therapy techniques. Also disclosed are pharmaceutical compositions for modulating growth of a neuron in a mammal that include a Wnt or a Wnt-like substance. Methods... |
| Method for mrna stabilization | 20080299662 | 20081204 |
| A method to increase the production of a desired chemical compound in a microorganism by introduction of a DNA sequence at the 5′ end of the encoding DNA gene sequence capable of forming a stem loop and capable of increasing the stability of mRNA transcripts from one or more genes, thus stabilized mRNAs, corresponding DNA sequences and microorganisms.
... |
| Cluster ion implantation for defect engineering | 20080299749 | 20081204 |
| A method of semiconductor manufacturing is disclosed in which doping is accomplished by the implantation of ion beams formed from ionized molecules, and more particularly to a method in which molecular and cluster dopant ions are implanted into a substrate with and without a co-implant of non-dopant cluster ion, such as a carbon cluster ion, wherein the dopant ion is implanted into the amorphous layer created by the co-implant in order to reduce defects in the crystalline structure, thus reducing the leakage current and improving performance of the semiconductor junctions. Dopant ion compounds of the form AnHx+ and AnRzHx+ are used in order to minimize crystal defects as a result of ion implantation. These compounds include co-implants of carbon clusters with implants of monomer or cluster... |
| Chemical compounds | 20080300285 | 20081204 |
| The use of a compound of formula (I) wherein X is (i), (ii) or (iii), formula (i), formula (ii), formula (iii) Y is O, S(O)m, NR3, CR5R6, CR5R6—CR7R8, O—CR7R8, S(O)m—CR7R8, NR3—CR7R8, CR5R6—O, CR5R6—S(O)m, CR5R6—NR3, SO2—NR3, NR3—SO2, NR3—O or O—NR3; m is 0, 1, or 2; the ring (T) formula (T) is a 5- or 6-membered aromatic or heteroaromatic ring; R1 to R10 are specified organic groups and n and is 0, 1, 2, 3 or 4; or salts or N-oxides thereof or compositions containing them in controlling insects, acarines, nematodes or molluscs. Novel compounds are also provided.
... |
| Eye lens material and method of manufacturing thereof | 20080300369 | 20081204 |
| The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof.
... |
| Ocular lens material and method for producing same | 20080300375 | 20081204 |
| The object of the present invention is to provide a contact lens that prevents protein adsorption and a method of manufacturing thereof.
... |
| Nano- and micro-scale wireless stimulating probe | 20080300663 | 20081204 |
| Untethered micro or nanoscale probes may be dispersed within tissue to be individually addressed through external electromagnetic radiation to create local electrical currents used for direct stimulation, alteration of cellular potentials, or the release or modification of contained or attached chemical compounds.
... |
| Compositions and methods relating to novel compounds and targets thereof | 20080293700 | 20081127 |
| The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
... |
| Chemical compounds | 20080293716 | 20081127 |
| There is provided a compound of Formula (I) or a salt, solvate, or physiologically functional derivative thereof:
... |
| Chemical compounds | 20080293802 | 20081127 |
| The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention
... |
| Vehicle passenger compartment air filter devices | 20080276805 | 20081113 |
| A vehicle passenger compartment air filter device comprising a filtration medium comprising (i) a first filter layer comprising a electrostatically charged split fiber nonwoven web layer and optionally a scrim affixed to said split fiber layer; (ii) a nonwoven web of electret charged thermoplastic microfibers as a second filter layer, said microfibers having an effective fiber diameter (EFD) of greater than 10 μm and comprising a thermoplastic resin having a resistivity greater than 1014 ohm−cm and an additive selected from fluorochemical compounds or oligomers, organic triazine compounds or oligomers, hindered amine compounds, aromatic amine compounds, nitrogen containing hindered phenols, metal containing hindered phenols and mixtures thereof; said web having a basis weight less than 60 g/m2; and (iii) a support layer made of a web material... |
| On chip dilution system | 20080277615 | 20081113 |
| An on-chip chemical compound dilution system for providing dilution of a chemical compound in a microfluidic application includes at least one sample well for providing a selected chemical compound to be diluted, a dilution well for providing a diluent for diluting the chemical compound, a network of channels for carrying the chemical compound and diluent, a first syringe pump for effecting dilution, a second syringe pump, a detector and a plurality of valves for selectively controlling the flow of liquid through the channels. The dilution system may be a multiple-stage dilution system for precisely mixing a plurality of chemical compounds in a diluent. The dilution system allows for accurate calibration to compensate for variations due to manufacturing, thereby providing precise dilution ratios. The dilution system further... |
| Method of isolating biologically active chemical compounds from a chemical compound library | 20080280770 | 20081113 |
| A method of producing a chemical compound library comprises extracting at least one extract from at least one species of plant; processing at least one of the extract(s) to remove at least one type of chemical interference to produce a processed extract; chromatographically separating the processed extract into a plurality of chromatographic fractions, each containing an amount of chemical compounds; determining the amount of chemical compounds in at least one of the chromatographic fractions; and normalizing the chromatographic fractions in which the amounts were determined to produce normalized chromatographic fractions, each such fraction comprising from about 1 microgram to about 500 micrograms of each of from one to seven chemical compounds that were present in lower concentrations in the extract and that each have a log... |
| Electro-optic prism systems | 20080271784 | 20081106 |
| Techniques and assemblies for steering light rays are described. An electro-optic prism configured to provide controllable steering of solar rays includes a first electrode including multiple substantially parallel linear electrodes positioned on a first substrate and a reference electrode positioned on a second substrate. An electro-optic material is positioned between the first electrode and the reference electrode. In one implementation, a wavelength selective filter is in optical communication with the electro-optic prism. The wavelength selective filter is configured to substantially eliminate selected wavelengths from solar rays before the solar rays are received by the electro-optic prism. In another implementation, a chemical compound is configured in the assembly to convert ultra-violet photons included in the solar rays into visible photons.
... |
| Integrated electrochemical and thermochemical renewable energy production, storage, distribution and recycling system | 20080274039 | 20081106 |
| A first aspect of the present invention is a self-contained electrolysis process. The process includes utilizing a cryogenic cogeneration process to extract a liquid from an atmospheric medium, passing a current through the liquid, and separating at least one chemical element from the liquid. A second aspect of the present invention is a self-contained electrolysis apparatus. The apparatus includes cryogenic cogeneration means for extracting a liquid from an atmospheric medium, electrical means for passing a current through the liquid and separating means for separating at least one chemical compound from the liquid. A third aspect of the present invention is a method and system of removing at least one element from a chemical compound. The method and system include utilizing a cryogenic cogeneration process to remove... |
| Process for preparing sugar-containing hydrolyzates from lignocellulose | 20080274509 | 20081106 |
| A sugar-containing hydrolyzate is produced from a lignocellulose-containing material by a) pretreating the lignocellulose-containing material with a chemical compound selected from sulphuric acid, alkali, peroxodisulphates, potassium peroxide, potassium hydroxide, and mixtures thereof, in the presence of water, thereby obtaining an aqueous phase, and b) after removing of the aqueous phase and washing the resulting product, treating said product with an enzyme suitable for hydrolysis in the presence of water, thereby obtaining a hydrolyzate, the hydrolyzate being suitable as a carbon source for fermentation.
... |
| Substituted quinazolones as anti-cancer agents | 20080275022 | 20081106 |
| The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
... |
| Chemical compounds | 20080275062 | 20081106 |
| wherein G is CH or N; and Y1 and Y2 are independently hydrogen, halogen and a group NR5R6 (wherein R5 and R6 are independently hydrogen, C1-6alkyl or C2-6alkenyl).
... |
| Methods and compositions related to delivery of chemical compounds to invertebrate embryos | 20080276327 | 20081106 |
| Disclosed are methods and compositions related to the delivery of chemical compounds to invertebrate embryos.
... |
| Transport protein which is used to introduce chemical compounds into nerve cells | 20070299008 | 20071227 |
| The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof.
... |
| Compostions and methods relating to novel compounds and targets thereof | 20070299059 | 20071227 |
| The present invention relates to novel chemical compounds, methods for their discovery, and their therapeutic use. In particular, the present invention provides benzodiazepine derivatives and methods of using benzodiazepine derivatives as therapeutic agents to treat a number of conditions associated with the faulty regulation of the processes of programmed cell death, autoimmunity, inflammation, and hyperproliferation, and the like.
... |
| Coated enossal implant | 20070299535 | 20071227 |
| The invention is an enossal implant with a coating that accelerates the healing-in process and counteracts demineralization of the bone when the cavities that are necessary for insertion of the implant are made. The invention elevates the osmotic pressure in the immediate vicinity of a freshly inserted implant so as to compensate quickly for the loss of salts and minerals of the chemical compounds and minerals contained in the bone and the bone fluid when the cavity is made. The surface of the implant may be, for example, coated with a dry crust of soluble NaCl crystals, which dissolves gradually after the insertion.
... |
| Solar cell and manufacturing method thereof | 20070290283 | 20071220 |
| A solar cell and a manufacturing method thereof. A method of manufacturing a solar cell includes: forming an emitter layer on a first surface of a semiconductor substrate; forming an insulation layer on the emitter layer; applying a chemical compound including a dopant having a conductive type of the emitter layer on the insulation layer according to a pattern; forming a high concentration emitter portion by removing a portion of the insulation layer corresponding to a positioning of the chemical compound and diffusing the dopant toward the emitting layer; removing the chemical compound; and forming a first electrode electrically connected to the high concentration emitter portion.
... |
| Chemical compounds | 20070292513 | 20071220 |
| Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
... |
| Cristalline and amorphous form of a triazolo (4,5-d) pyridimine compound | 20070293513 | 20071220 |
| The invention provides new forms of a chemical compound of formula (I). The invention relates to forms fo a chemical compound (I), in particular to crystalline and amorphous forms, more particularly four crystalline forms and an amorphous form. The invention further relates to processes for the preparation of such forms, to pharmaceutical compositions comprising the compound in crystalline and/or amorphous form and to therapeutic use of such forms.
... |
| Fire resistant and smoke suppressing coatings | 20070284120 | 20071213 |
| A surface coating includes fire retarding and smoke suppressing constituents dispersed throughout an essentially non-toxic, water-based adhesive binder. The coating comprises a mixture of chemical compounds where each constituent falls into one of six functional groups, being: 1) catalyst/initiator; 2) expandable graphite; 3) carbonific, or source of carbon which additionally forms water; 4) blowing agent (a source of non-flammable gases); 5) cement; and, 6) ceramic.
... |
| Fluidic methods for devices for parallel chemical reactions | 20070281357 | 20071206 |
| Fluidic methods and devices for conducting parallel chemical reactions are disclosed. The methods are based on the use of in situ photogenerated reagents such as photogenerated acids, photogenerated bases, or any other suitable chemical compounds that produce active reagents upon light radiation. The present invention describes devices and methods for performing a large number of parallel chemical reactions without the use of a large number of valves, pumps, and other complicated fluidic components. The present invention provides microfluidic devices that contain a plurality of microscopic vessels for carrying out discrete chemical reactions. Other applications may include the preparation of microarrays of DNA and RNA oligonucleotides, peptides, oligosacchrides, phospholipids and other biopolymers on a substrate surface for assessing gene sequence information, screening for biological and chemical activities,... |
| Producing ethanol and saleable organic compounds using an environmental carbon dioxide reduction process | 20070282021 | 20071206 |
| Carbon dioxide, from a greenhouse gas source, is reacted with hydrogen, developed in an environmentally friendly process, such as from solar energy based electrolysis, to produce a mixture of ethanol and other saleable organic compounds. The ethanol and other saleable organic compounds mixture may contain substantial percentages of methanol, ethanol, and dimethylether in addition to other components which have chemical structures of predominantly carbon and hydrogen or carbon, hydrogen and oxygen. The saleable organic compounds, such as methane, methanol and ethanol may be used as a combustible fuel thus developing a green energy cycle. A portion of the organic compounds may be separated into essentially pure components and used as chemical process feed stocks. The essentially pure organic compounds may be further reacted with suitable chemical... |
| Chemical compounds | 20070276000 | 20071129 |
| The present invention relates to cycloalkylidene compounds with a variety of therapeutic uses, more particularly novel naphthalene compounds that are particularly useful for selective estrogen modulation.
... |
| Chemical compounds | 20070270427 | 20071122 |
| Pyrimidine derivatives, which are useful as VEGFR2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
... |
| Contrast agents | 20070264201 | 20071115 |
| The present invention relates to a class of compounds and to diagnostic compositions containing such compounds where the compounds are iodine containing compounds. More specifically the iodine containing compounds are chemical compounds containing an aliphatic central moiety containing hydroxyl groups allowing for the arrangement of three iodinated phenyl groups bound thereto. The invention also relates to methods employing such diagnostic compositions as contrast agents in diagnostic imaging and in particular in X-ray imaging and to contrast media containing such compounds.
... |
| Method and apparatus for separation of chemical materials from feces | 20070256973 | 20071108 |
| A method and apparatus for treatment of feces is present in which usable organic and inorganic chemical compounds and substances are extracted from the fecal material for reuse. The process and apparatus includes receiving a mixture of fecal material from various sources, separating the liquid from the solids for further processing or disposal, mixing the solids with an acid and/or solvent solution to break down the solids into components to be extracted, filtering solids from the mixture, distilling the filtrate to remove remaining solvents, reacting the remaining solids with a metal hydroxide solution to yield fats, fatty acids, oils, alcohols, sugars, and other minerals, and further processing these materials to produce lubricants, grease, emulsifiers, biodiesel, fuels and/or fertilizers.
... |
| Chemical formulations for removal of hazardous pollutants from combustion gases | 20070259781 | 20071108 |
| Various formulations of chemical compounds are disclosed to help improve the removal of fine particulates and hazardous substances present in combustion gases of fossil and derived fuels. Specifically, the formulation consists of bicarbonate and carbonate of ammonia with or without borates, formates and acetates of sodium and lithium, poly-hydroxy compounds, iodides and sulfides of ammonia and sodium, elemental iodine, elemental sulfur and mixture thereof The formula when injected into a combustion gas stream of a system fitted with an electrostatic precipitator and/or bag house helps remove the fine particulates and hazardous materials present in it.
... |
| Azine-carboxamides as anti-cancer agents | 20070259849 | 20071108 |
| The invention relates to chemical compounds, of the formula (I): or pharmaceutically acceptable salts thereof, which possess B-Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.
... |
| Chemical compounds | 20070254873 | 20071101 |
| where R1, R2, R3, U and V are defined below and to pharmaceutically acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKKβ) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
... |
| Chemical compounds | 20070254910 | 20071101 |
| The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to a chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a target cell.
... |
| Reagents and methods for using human embryonic stem cells to evaluate toxicity of pharmaceutical compounds and other chemicals | 20070248947 | 20071025 |
| The invention provides biomarker profiles of cellular metabolites and methods for screening chemical compounds including pharmaceutical agents, lead and candidate drug compounds and other chemicals using human embryonic stem cells (hESC) or lineage-specific cells produced therefrom. The inventive methods are useful for testing toxicity, particularly developmental toxicity and detecting teratogenic effects of such chemical compounds.
... |
| Novel chemical compounds | 20070249599 | 20071025 |
| This invention relates to the newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
... |
| Chemical compounds | 20070249600 | 20071025 |
| Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
... |
| Gas supply device and apparatus for gas etching or cleaning substrates | 20070240826 | 20071018 |
| A gas supply device, including: a first source of an inert carrier gas, communicated with a first pipeline; a second source of anhydrous reactive gas, communicated with a second pipeline; a third source of enabling chemical gas of an enabling chemical compound, communicated with a third pipeline; a main pipeline, communicated with the first, second, and third pipelines; and a temperature controller, located on the second pipeline.
... |
| Method and apparatus for separation of chemical materials from feces | 20070227985 | 20071004 |
| A method and apparatus for treatment of feces is present in which usable organic and inorganic chemical compounds and substances are extracted from the fecal material for reuse. The process and apparatus includes receiving a mixture of fecal material from various sources, separating the liquid from the solids for further processing or disposal, mixing the solids with an acid and/or solvent solution to break down the solids into components to be extracted, filtering solids from the mixture, distilling the filtrate to remove remaining solvents, reacting the remaining solids with a metal hydroxide solution to yield fats, fatty acids, oils, alcohols, sugars, and other minerals, and further processing these materials to produce lubricants, grease, emulsifiers, biodiesel, fuels and/or fertilizers.
... |
| Organic-inorganic composite semiconductor material, liquid material, organic light emitting element, method of manufacturing organic light emitting element, light emitting device and electronic apparatus | 20070228356 | 20071004 |
| where Ar1, Ar2 and Ar3 are each independently an aromatic ring group that optionally has a substituent group.
... |
| Method for identifying drug targets by mass spectrometry | 20070231827 | 20071004 |
| The present invention is an improved method for identifying in vivo protein targets, which bind specifically to a chemical compound. A sample is divided into two sets, to one of which a chasing compound is added. Two sets are then purified by affinity column, digested and labeled for mass spectrometry analysis. A comparison of the peak intensities of the same peptide between the two sets distinguishes a real binding target from a contamination.
... |
| Chemical derivatives as antitelomerase agents which bind specifically to the g-quadruplex dna structures and their application as a specific anticancer agent | 20070232572 | 20071004 |
| The present invention relates to cancer therapy and to novel anticancer agents having a mechanism of action which is quite specific. It also relates to novel chemical compounds and their therapeutic application in humans.
... |
| Chemical compounds | 20070232615 | 20071004 |
| The present invention provides novel compounds that demonstrate protective effects on target cells from HIV infection in a manner as to bind to a chemokine receptor, and which affect the binding of the natural ligand or chemokine to a receptor such as CXCR4 of a target cell.
... |
| Heat recovery gas absorption process | 20070221065 | 20070927 |
| Apparatus comprising an absorber device provided with a plurality of sequentially adjacent sections for flowing a gas stream therethrough. A conduit infrastructure comprising a section configured to ingress, communicate with and egress from each section of the absorber device, and a recovery and regeneration section, is configured with a plurality of heat exchange and cooling equipment. A process wherein a liquid solvent provided with at least one chemical compound selected for reacting with the selected gaseous component, is counter-flowed against and commingled with the gas stream. The liquid solvent temperature is controllably manipulated between each section of the column to provide: (a) thermodynamic-driven mass transfer at the front end of the absorber device, and (b) kinetic-driven mass transfer at the back end of the absorber device.... |
| Fluorochemical composition for rendering substrates oil and/or water repellent | 20070221877 | 20070927 |
| The present invention provides a composition comprising an aqueous dispersion of a fluorochemical compound and a cationic surfactant and wherein the composition further comprises colloidal inorganic particles.
... |
| Stabilization of chemical compounds using nanoparticulate formulations | 20070224279 | 20070927 |
| Methods for stabilizing chemical compounds, particularly pharmaceutical agents, using nanoparticulate compositions are described. The nanoparticulate compositions comprise a chemical compound, such as a pharmaceutical agent, and at least one surface stabilizer. The component chemical compound exhibits chemical stability, even following prolonged storage, repeated freezing-thawing cycles, exposure to elevated temperatures, or exposure to non-physiological pH conditions.
... |
| Toxicity screening methods | 20070218457 | 20070920 |
| The present invention provides methods of determining a level of toxicity of a given compound based on in vitro assays. The present invention provides particular methods of determining organ-specific toxicity and species-specific toxicity of a given compound based on in vitro assays. In addition, the present invention provides methods of determining a level of toxicity in normal tissue for an anti-tumor compound. The methods include providing at least one cell type and culturing the cell type in the presence of at least one concentration of the chemical compound, measuring at least one indicator of cell health at the at least one concentration of compound for the at least one cell type, and performing a concentration response analysis, from which a toxic concentration can be determined.
... |
| Cell lines for expressing enzyme useful in the preparation of amidated products | 20060292672 | 20061228 |
| Cell lines are provided for expressing peptidylglycine alpha-amidating monooxygenase (PAM), or one of its two catalytic domains. High levels of enzyme expression are achieved while utilizing a non-animal source, low protein tissue culture medium. A robust two-step downstream purification results in high enzyme purity. Resulting PAM, or its PHM catalytic domain, is used to catalyze the enzymatic conversion of X-Gly to X-alpha-hydroxy-Gly or X—NH2 (X being a peptide or any chemical compound having a carbonyl group to which a glycine group can be covalently attached). Methods of preparing preferred cell lines are also set forth.
... |
| Novel chemical compounds | 20060293338 | 20061228 |
| This invention relates to newly identified compounds for inhibiting hYAK3 proteins and methods for treating diseases associated with the imbalance or inappropriate activity of hYAK3 proteins.
... |
| Methods for synthesis of carotenoids, including analogs, derivatives, and synthetic and biological intermediates | 20060293545 | 20061228 |
| A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
... |
| Glow discharge and photoionization source | 20060284103 | 20061221 |
| A detector that may contain a glow discharge ionizer and a photo-ionizer. The existence of both ionizers may increase the accuracy and number of chemical compounds that can be simultaneously monitored for chemical screening applications. The detector is particularly useful for screening explosives, chemical agents, and other illicit chemicals.
... |
| Method and apparatus for the treatment of fluid waste streams | 20060286006 | 20061221 |
| This invention relates generally to methods and apparatus for the detoxification of fluid streams, for example, wastewater contaminated with neurotoxins, particularly organophosphorous compounds, and comprises contacting the fluid stream with a bioactive coating. More particularly, the invention relates to chemical reactors for detoxifying fluid streams and also, bioactive coated support components comprising rigid, semi-rigid, or flexible support materials coated with a bioactive coating compriseing dessicated whole cells, whole cell fragments, enzymes, and combinations thereof that are capable of hydrolizing neurotoxic organophosphorous chemical compounds. Organophosphorus hydrolases that are capable of detoxifying organophosphorus compounds that are: chemical weapons agents, in particular, tabun (“GA”), sarin (“GB”), soman (“GD”), cyclosarin, VX, and its isometric analog Russian VX (“VR” or “R-VX”); chemical weapons agent analogs, chemical weapons surrogates; and pesticides are... |
| Liquid discharge head manufacturing method, and liquid discharge head obtained using this method | 20060277755 | 20061214 |
| According to the present invention, a method for manufacturing a liquid discharge head includes the steps of: forming a solid layer for forming a flow path on a substrate on which an energy generating element is arranged to generate energy that is used to discharge liquid; forming, on the substrate where the solid layer is mounted, a coating layer for coating the solid layer; forming a discharge port used to discharge a liquid, through a photolithographic process, in the coating layer deposited on the solid layer; and removing the solid layer to form a flow path that communicates with the energy element and the discharge port, whereby a material used for the coating layer contains a cationically polymerizable chemical compound, cationic photopolymerization initiator and an inhibitor... |
| Rotating member, housing, bearing, gearbox, rotating machine, shaft structure, and surface treatment method | 20060280597 | 20061214 |
| In a rotation member (5) rotatably engaged with a housing (3), a pulsing electric discharge is generated in a processing liquid or in a gas, between an electrode and the rotation member (5). The electrode is a chemical compound from metallic powder or metal, or a molded body formed by molding ceramic powder, or a molded body obtained by heating the molded body. Energy of the electric discharges causes coating to be formed on an engagement portion (15) engaging the housing (3), the coating formed from the material of the electrode or a substance to which the electrode material combined by the energy of the electric discharges.
... |
| Parallel flow fractionation tray | 20060273616 | 20061207 |
| The invention comprises multiple configurations of downcomers in a parallel flow multiple downcomer tray for vapor-liquid contacting processes such as the separation of chemical compounds via fractional distillation or the removal of a component of a gas stream with a treating liquid. In one embodiment, side downcomers are incorporated into a parallel flow multiple downcomer tray. In another embodiment, the downcomers have an inclined side wall that directs liquid onto the deck below the downcomer. The inclined side wall also provides additional volume above the inferior downcomer inlet to reduce pinching at this inlet without the need for a stilling deck.
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| System, apparatus and method for detecting unknown chemical compounds | 20060266102 | 20061130 |
| Apparatus and techniques for detecting unknown chemical compounds in the field are provided. A Digital Signal Processor (DSP) includes a database of chemical signatures and corresponding chemicals. An air sample is analyzed in the field and chemical signature of any chemicals present is determined. This chemical signature is then correlated with the chemicals in the database. If a match is found, the operator is alerted to the fact. If no match is found, the operator is alerted to the fact that an unknown chemical compound is found but no correlation could be found. A corresponding system and method are provided.
... |
| Semiconductor device and method of manufacturing same | 20060267030 | 20061130 |
| A FET is formed on a semiconductor substrate, a curved surface having a radius of curvature is formed on an upper end of an insulation, a portion of a first electrode is exposed corresponding to the curved surface to form an inclined surface, and a region defining a luminescent region is subjected to etching to expose the first electrode. Luminescence emitted from an organic chemical compound layer is reflected by the inclined surface of the first electrode to increase a total quantity of luminescence taken out in a certain direction.
... |
| Electrochemical method for the direct nanostructured deposition of material onto a substrate, and semiconductor component produced according to said method | 20060269688 | 20061130 |
| A method of fabricating a nano-scaled semiconductor by depositing upon a substrate, within the confines of a narrowly limited electric field, from an adjustable mixture of precursor gases containing different precursor compounds, nano-scaled deposits of common chemical compounds released in consequence of the precursor compounds breaking down upon the simultaneous or sequential application of a voltage exceeding a predetermined threshold value.
... |
| Chemical compounds | 20060270692 | 20061130 |
| Quinazoline derivatives of formula (I); for use in the treatment of proliferative diseases such as cancer and in the preparation of medicaments for use in the treatment of proliferative diseases, and to process for their preparation, as well as pharmaceutical compositions containing them as active ingredient.
... |
| Miniaturized detection coil former for nmr spectroscopy | 20060261814 | 20061123 |
| One exemplary miniaturized detection coil former for NMR spectroscopy includes a macroporous carrier material having a first surface and a second surface situated opposite thereto, as well as a multiplicity of discrete pores formed in the carrier material and having a diameter in the range of 500 nm to 100 μn being arranged in a manner distributed over at least one surface region. The pores extend through the carrier material from the first to the second surface. A radiofrequency microcoil is embedded in the macroporous carrier material. The detection coil former finds particular utility in an NMR overall analysis system for the NMR-spectroscopic analysis of chemical compounds in the liquid phase.
... |
| Flourescent chemical compounds having high selectivity for double standard dna, and methods for their use | 20060263844 | 20061123 |
| Chemical compounds having a high selectivity for double stranded DNA over RNA and single stranded DNA are disclosed. The chemical compounds are stains that become fluorescent upon illumination and interaction with double stranded DNA, but exhibit reduced or no fluorescence in the absence of double stranded DNA. The compounds can be used in a variety of biological applications to qualitatively or quantitatively assay DNA, even in the presence of RNA.
... |
| Chemical compounds | 20060264463 | 20061123 |
| The present invention provides a compound of a formula (1): wherein the variables are defined herein; to a process for preparing such a compound; and to the use of such a compound in the treatment of a chemokine (such as CCR3) or H1 mediated disease state.
... |
| Spectrometer chip assembly | 20060255255 | 20061116 |
| Method and apparatus for high field asymmetric waveform ion mobility spectrometry in an electronic chip assembly, including an input section, an ion filter and detection section and a control section, in which ion filtering proceeds in a planar chamber under influence of high field asymmetric periodic signals, with detection integrated into the flow path, for producing accurate, real-time, data for identification of a broad range of chemical compounds.
... |
| Spatially addressable combinatorial chemical array in cd-rom format | 20060257939 | 20061116 |
| A method for preparing very large spatially-addressable arrays of chemical compounds by light-directed synthesis is provided, wherein the light is provided by a laser and the compounds are arrayed on a rotating disc in a CD-ROM format. A method for assaying the resulting array with a CD-ROM mechanism is also provided.
... |
| Anti-tumor substances | 20060258743 | 20061116 |
| Staphylococcus may preferably be Staphylococcus lentus. Further, the tumor cell-derived material may preferably be an Ehrlich tumor cell-derived material.
... |
| Apparatus and method for determining a chemical element | 20060249401 | 20061109 |
| To be able to use the sensor more variably and more reliably, it is proposed to produce a surface topology of such dimensions that during operation, a moisture film (16) of deposited ambient moisture continuously coats the surface area of both the electrode system and the reaction area. Possibilities in particular are correction of long-term changes from the influence of surrounding gases, checking probe functionality, and selective adjustment to measure given chemical variables.
... |
| New tetracyclic 6 azapyrazinoindolines as 5ht2c receptor agonists for obesity | 20060252759 | 20061109 |
| as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R5 have the significance given in claim 1. These compounds can be used for the preparation of medicaments.
... |
| Isocoumarin-based inhibitors of urokinase-type plasminogen activator | 20060252823 | 20061109 |
| R8 is H, an optionally substituted C1-C6 alkyl group, or together with R7 forms an optionally substituted 5-7 membered saturated or unsaturated carbocyclic group, an optionally substituted 5-7 membered saturated or unsaturated heterocyclic group, or an optionally substituted aromatic or heteroaromatic group; and pharmaceutically acceptable salts, thereof.
... |
| Activated oxidizing vapor treatment system and method | 20060252974 | 20061109 |
| An oxidizing liquid (20), such as hydrogen peroxide, is vaporized (18) and the vapor is used to deactivate nerve gas, blistering gas, or other biologically active substances such as pathogens, biotoxins, and prions. A second chemical compound (42) in vapor, mist, or fog form is used in conjunction with the oxidizing vapor. In one embodiment, the second chemical preconditions the biologically active substances to be deactivated more efficiently by the oxidizing vapor. In another embodiment, the second chemical boosts the reactivity of the oxidizing vapor. In another embodiment, the other chemical reacts with the oxidizing vapor to form an intermediate compound that deactivates at least some of the biologically active substances.
... |
| Translocation dependent complementation for drug screening | 20060247419 | 20061102 |
| The present invention relates to various uses of complementing proteins protein fragments to discover chemical compounds or drugs interfering with protein translocation/redistribution and/or protein interactions. The invention takes advantage of the fact that many interacting proteins reside in separate and distinct locations prior to the activation of the signaling pathways in which they play their part. The invention also takes advantage of interaction domains (FRBP, FKBP12) that can be induced to interact. Specifically disclosed are GFP (EGFP, F64L mutated EYFP) complementation.
... |
| Chemical compounds | 20060241149 | 20061026 |
| Pyridinyl-benzoheterocycyl kinase inhibitor compounds are disclosed. Also disclosed are methods of making such compounds as well as methods of using the same in the treatment of diseases.
... |
| Peptides for the treatment of cancer associated with human papilloma virus (hpv) and other epithelial tumours | 20060233742 | 20061019 |
| This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as... |
| Method for grafting a chemical compound to a support substrate | 20060234062 | 20061019 |
| According to the present invention a method for grafting a chemical compound to a predetermined region of a support substrate (4) is disclosed, comprising: a) irradiating selectively the support substrate with electromagnetic radiation and/or particle radiation in order to both define said predetermined region and to form at least one reactive functional group or a precursor thereof in said predetermined region of the support substrate; b) exposing the irradiated support substrate to said chemical compound or to a precursor thereof. Therefore, only these very few steps are needed to effectively grafting the desired chemical compound, such as an organic compound, to the predetermined regions of the support substrate. Moreover, the irradiation step can be carried out in a vastly flexible manner and allows to generate numerous... |
| Polyglutamine repeat sequences | 20060234385 | 20061019 |
| Several neurodegenerative diseases result from the aggregation of polyglutamine repeat proteins into insoluble neuronal intranuclear inclusions. The invention provides methods with which to study the processes of these diseases, including methods for solubilizing polypeptides containing a polyglutamine repeat sequence, for storing these polyglutamine polypeptides and inhibit their spontaneous aggregation, for making the aggregates of polyglutamine polypeptides, for assaying the extension of existing polyglutamine aggregates, for determining the ability of a chemical compound to inhibit aggregation, and for inhibiting aggregation of polyglutamine polypeptides. The invention further provides materials with which to study these diseases including a synthetic aggregate that have a capability to recruit additional monomeric polyglutamine polypeptides and chemical compounds that inhibit the formation and/or extension of polyglutamine aggregates.
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| Method of judging quality of semiconductor epitaxial crystal wafer and wafer manufacturing method using the same | 20060234400 | 20061019 |
| In a method of determining the quality of a semiconductor epitaxial crystal wafer having a buffer structure portion comprised of epitaxial layers the semiconductor epitaxial crystal wafer (S) is irradiated with pulsed exciting light (5A) to modulate an internal electric field of the buffer structure portion, the electric transport properties deriving from the crystal quality of the buffer structure of the semiconductor epitaxial crystal wafer (S) are predicted based on a spectral difference in reflectance in reflection probe light (3B) from the semiconductor epitaxial crystal wafer (S), to determine the crystal quality of the buffer structure portion. The crystal quality may also be determined based on electric field strength calculated from Franz-Keldysh oscillation originating in the semiconductor chemical compound of the buffer structure portion.
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| Hybrid stoichiometric analysis and imaging using non-thermal and thermal neutrons | 20060227920 | 20061012 |
| An apparatus and method for analyzing and imaging chemical compounds within a test subject uses subatomic particle activation. The test subject (and chemical compounds contained therein) is irradiated by non-thermal neutrons, thereby generating thermal neutrons within the test subject and stimulating the emission of gamma rays. Gamma ray detectors detect the emitted gamma rays and energy signals derived from the gamma ray detectors are filtered to eliminate non-relevant spectral artifacts.
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| Use of isatin in stimulating red blood cell production and treatment of anemia | 20060229354 | 20061012 |
| The present invention concerns small chemical compounds—Isatin and its derivatives, and a novel, safer and more convenient methods for the treatment of anemia resulting from various underlying conditions or diseases. The invention provides new methods to stimulate red cell production, and the new methods to prevent the development of anemia. The invention provides a new therapeutic approach for the treatment of chronic anemia patients, anemia patients who are receiving bone marrow suppressive therapies, HIV/AIDS patients who develop anemia upon the treatment of anti-retroviral therapies or from underlying disease itself, and anemia with other causes. The invention also provides methods for preventing anemia in many relatively healthy people such as young women who loss blood from menstrual blood.
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