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Cells patents



      
           
This page is updated frequently with new Cells-related patent applications. Subscribe to the Cells RSS feed to automatically get the update: related Cells RSS feeds. RSS updates for this page: Cells RSS RSS


Treatment apparatus and use thereof for treating psoriasis

Koninklijke Philips N.v.

Treatment apparatus and use thereof for treating psoriasis

Date/App# patent app List of recent Cells-related patents
01/22/15
20150026844
 Transgenic bioluminescent plants patent thumbnailnew patent Transgenic bioluminescent plants
Transgenic plants, and a method for making the same, wherein genes encoding the enzyme luciferase and its corresponding substrate luciferin are incorporated into a native plant genome. Once transformed into plant cells, these genes may be regulated such that under certain endogenous or exogenous conditions, their expression in the mature plant results in bioluminescence.
01/22/15
20150026843
 Polypeptides having protease activity patent thumbnailnew patent Polypeptides having protease activity
The present invention relates to isolated polypeptides having proteaseactivity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptidesin e.g.
Novozymes A/s
01/22/15
20150026831
 Tl1a model of inflammation fibrosis and autoimmunity patent thumbnailnew patent Tl1a model of inflammation fibrosis and autoimmunity
This invention relates transgenic animals that overexpress tl1a in a tissue specific manner to model inflammatory bowel disease (ibd), such as colitis, crohn's disease and ulcerative colitis, fibrosis, and related inflammatory diseases and conditions. Tl1a transgenic animals constitutively express both tl1a and gfp in lymphoid and myeloid cell lineages, allowing convenient identification and sorting of immune cells involved in ibd disease progression, such as t-cells, antigen presenting cells (apc), and dendritic cells (dc).
Cedars-sinai Medical Center
01/22/15
20150026554
 Device, method, and graphical user interface for manipulating tables using multicontact gestures patent thumbnailnew patent Device, method, and graphical user interface for manipulating tables using multicontact gestures
An electronic device having a display and a touch-sensitive surface, displays a table having a plurality of rows, a plurality of columns, and a plurality of cells. The device detects a gesture on the touch-sensitive surface that includes movement of one or more of a first contact and a second contact.
Apple Inc.
01/22/15
20150026537
 Memory device with over-refresh and method thereof patent thumbnailnew patent Memory device with over-refresh and method thereof
A method for over-refreshing a memory device comprises in a refreshing cycle, refreshing normal cells and a weak cell, and additionally refreshing the weak cell at least once.. .
Taiwan Semiconductor Manufacturing Company Ltd.
01/22/15
20150026393
 Semiconductor memory device patent thumbnailnew patent Semiconductor memory device
A semiconductor memory device includes a memory array, a setting unit and a control unit. The memory array consists of non-volatile memory cells.
Winbond Electronics Corp.
01/22/15
20150026386
 Erase management in memory systems patent thumbnailnew patent Erase management in memory systems
Computer processor hardware receives notification that data stored in a region of storage cells in a non-volatile memory system stores invalid data. In response to the notification, the computer processor hardware marks the region as storing invalid data.
01/22/15
20150026207
 Managing sparsity in an multidimensional data structure patent thumbnailnew patent Managing sparsity in an multidimensional data structure
Embodiments of the present invention relate to a method, program product, and system for managing the percentage of unpopulated cells in a multidimensional data structure during the servicing of multidimensional analytical queries. In an embodiment, a multidimensional data structure is stored in a memory location of a computing device, wherein the multidimensional data structure includes a dimension that is a subset of a plurality of dimensions included in a relational database.
International Business Machines Corporation
01/22/15
20150026194
 Finding a best matching string among a set of strings patent thumbnailnew patent Finding a best matching string among a set of strings
A method for finding a best matching string among a set of strings for a reference string includes representing, for each of the set of strings paired with the reference string, a dynamic programming problem for calculating a final alignment score as a matrix of cells, and calculating a current optimal alignment boundary threshold. The method also includes executing, for each string of the set of strings, a calculation of a prospective final alignment score of a candidate alignment of the each of the set of strings and the reference string for each cell.
International Business Machines Corporation
01/22/15
20150026116
 Managing sparsity in an multidimensional data structure patent thumbnailnew patent Managing sparsity in an multidimensional data structure
Embodiments of the present invention relate to a method, program product, and system for managing the percentage of unpopulated cells in a multidimensional data structure during the servicing of multidimensional analytical queries. In an embodiment, a multidimensional data structure is stored in a memory location of a computing device, wherein the multidimensional data structure includes a dimension that is a subset of a plurality of dimensions included in a relational database.
International Business Machines Corporation
01/22/15
20150025833
new patent

System and prediction of temperature values in an electronics system


In accordance with at least one embodiment, a computer-implemented method for evaluating cooling performance of an electronics system is provided. The method includes acts of dividing the electronics system into a computational grid including a plurality of fluid cells and a plurality of solid cells, determining air flow values for the plurality of fluid cells using a potential flow model analysis, determining a temperature of a fluid cell by calculating heat transfer into the fluid cell from any adjacent fluid cells and from any adjacent solid cells, determining a temperature of a solid cell by calculating heat transfer into the solid cell from any adjacent solid cells and heat transfer out of the solid cell into any adjacent fluid cells, and storing, on a storage device, the air flow values and the temperature of the fluid cell and the temperature of the solid cell..
01/22/15
20150025825
new patent

Battery pack and calculating electric energy of battery pack


A battery pack (10) includes a plurality of battery cells (100) which are connected in series to each other, a voltage and current measurement unit (voltage and current measurement unit (200)), a temperature measurement unit (temperature measurement unit (300)), and a calculation unit (calculation unit (420)) provided in an arithmetic operation communication unit (400). The calculation unit (420) calculates a “first electric energy balance” of the battery cells (100) on the basis of voltages and currents, determines internal resistances of the battery cells (100) on the basis of the temperatures, and calculates a “second electric energy balance” of the internal resistances on the basis of currents and the internal resistances.
Nec Energy Devices, Ltd.
01/22/15
20150025602
new patent

Treatment apparatus and use thereof for treating psoriasis


A treatment apparatus (10) is used for treatment of parts of a skin (5). The apparatus comprises a radiation source (1) emitting radiation, and a radiator (2) for guiding the emitted radiation to the parts of the skin (5).
Koninklijke Philips N.v.
01/22/15
20150025439
new patent

Apparatus, system, and generating photo-biologic minimum biofilm inhibitory concentration of infrared light


Systems and methods are disclosed herein for prophylactic application of near-infrared optical energies and dosimetries to photo-biologically inhibit accelerations or intensifications in biofilm production, after a bacterial or fungal pathogen is challenged with an antibiotic or antifungal agent. This photo-biologic minimum biofilm inhibitory concentration (pmbic) of infrared light will lower the minimum inhibitory concentration (mic) necessary of an antibiotic and/or antifungal molecule necessary to decrease bacterial and fungal pathogens in human tissues.
Nomir Medical Technologies, Inc.
01/22/15
20150025422
new patent

Methods and devices for modulating cellular activity using ultrasound


The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities.
Arizona Board Of Regents For And On Behalf Of Arizona State University
01/22/15
20150025420
new patent

Ultrasound treatment device and methods of use


A method can include targeting a region of interest below a surface of skin, which contains fat lobuli and delivering ultrasound energy to the region of interest. The ultrasound energy generates a conformal lesion with said ultrasound energy on a surface of a fat lobuli.
Guided Therapy Systems, Llc
01/22/15
20150025311
new patent

Small single-port arthroscopic lavage, directed tissue drying, biocompatible tissue scaffold and autologous regenerated cell placement delivery system


A system for performing arthroscopic lavage, directed tissue drying, and the accurate placement of a biocompatible tissue scaffold for the adherence of autologous regenerated cells through a small single port of entry into a joint compartment. The system is comprised of a handpiece having valves for irrigation and suctioning and a dual valve swivel cannula attached to the handpiece.
01/22/15
20150025234
new patent

Ganglioside compositions


The invention provides novel gangliosides and mixtures of novel gangliosides, and drug products containing the same. The invention also provides cells induced to over-express one or more gangliosides.
Garnet Biotherapeutics, Inc.
01/22/15
20150025232
new patent

Heptamer-type small guide nucleic acids inducing apoptosis of human leukemia cells


There is provided a heptamer-type small guide nucleic acid that comprises any of the 7-base sequences of seq id nos: 1 to 15, and induces apoptosis of human leukemia cells. A leukemia therapeutic agent containing the heptamer-type small guide nucleic acid as an active ingredient is also provided.
01/22/15
20150025230
new patent

Single nucleotide polymorphisms in brca1 and cancer risk


The invention provides methods for identifying mutations, such as single nucleotide polymorphisms (snps), within breast and ovarian cancer associated genes that modify the binding efficacy of micrornas (mirnas). In a preferred embodiment, methods of the invention identify a snp that decreases expression of the brca1 gene by increasing or decreasing the binding efficacy of at least one mirna.
Yale University
01/22/15
20150025222
new patent

Substituted anthraquinone dyes for cellular stains and enzyme detection


The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells.
Biotium, Inc.
01/22/15
20150025221
new patent

Skin permeating and cell entering (space) peptides and methods of use thereof


The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (sc) and/or the cellular membranes of viable cells.. .
The Regents Of The University Of California
01/22/15
20150025219
new patent

Cyclic pentadepsipeptides and microorganism of fusarium strain producing the same


Disclosed is a fusarium strain producing novel cyclic pentadepsipeptides which are of excellent multidrug resistance-reversing activity and inhibitory activity against cancer cells. Also, novel cyclic pentadepsipeptides are provided as active ingredients of the compositions useful in the treatment of cancer and diseases associated with multidrug resistance..
Chung-ang University Industry-academy Cooperation Foundation
01/22/15
20150025124
new patent

Compositions and methods for the suppression of target polynucleotides from lepidoptera


Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant.
E I Du Pont De Nemours And Company
01/22/15
20150025123
new patent

P2x7, inhibition of epithelial cancers and papillomas


The present invention demonstrates that p2x7 receptor induced apoptosis may be specific for cancerous cells. Treatment with the p2x7 ligand bzatp, increased cellular apoptosis with no associated inflammatory changes or abnormal skin or systemic effects.
University Hospitals Cleveland Medical Center
01/22/15
20150025083
new patent

Procaspase combination therapy for glioblastoma


The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells.
Vanquish Oncology, Inc.
01/22/15
20150025052
new patent

Compositions and methods for inhibiting hsp90/hsp70 machinery


Pharmaceutical compositions including an effective amount of a capsaicin and inhibitors of hsp90 to decrease or inhibit hsp70 and hsp90 chaperone pathways in cells are disclosed. Methods of inhibiting the hsp70 and hsp90 chaperone pathways including contacting cells expressing the hsp70/hsp90 complex with an effective amount of a capsaicin in combination with inhibitors of hsp90 to decrease or inhibit the hsp70 and hsp90 chaperone pathways are provided.
Georgia Regents Research Institute, Inc.
01/22/15
20150025036
new patent

Use of an active principle derived from eucheuma cottonii and rich in linear galactans for controlling skin cell aging


A cosmetic active principle produced by the hydrolysis of eucheuma cottonii and including linear galactans, as well as to the use thereof for promoting the protection of the telosome and telomeres of skin cells and thereby preventing and/or controlling skin aging. Also, the cosmetic compositions including the active principle and a cosmetic skincare method..
Societe Industrielle Limousine D'application Biolo
01/22/15
20150025031
new patent

Metabolic downregulation for cell survival


The present invention provides a system and method of maintaining and/or increasing cell viability by downregulating cellular metabolic rate under hypoxic conditions, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged. The present invention also relates to a system and method of prolonging the survival of implanted cells that are under hypoxic condition until host neovascularization is achieved, wherein the availability of adenosine or derivatives thereof in the cell is increased and/or prolonged.
Wake Forest University Health Sciences
01/22/15
20150025029
new patent

Aptamer bioconjugate drug delivery device


A delivery device for a active agent comprises nanoparticles based on a biopolymer such as starch. The delivery device may also be in the form of an aptamer-biopolymer-active agent conjugate wherein the aptamer targets the device for the treatment of specific disorders, such as cancer.
Ecosynthetix Ltd.
01/22/15
20150025022
new patent

Novel il-17r-ecd mutants


Provided are engineered soluble hil-17ra receptors with high affinity to hil-17 that inhibit downstream il17a induced signaling events in cells. Also provided are methods of inhibiting hil-17a induced secretion of cxcl1 and/or il-6 in cells, as well as methods of treating inflammation and/or inflammatory disorders in a subject..
01/22/15
20150025018
new patent

Method for inhibiting euptx3 to treat nasopharyngeal carcinoma by amino acid sequence


The invention relates to a method for inhibiting euptx3 to treat nasopharyngeal carcinoma by an amino acid sequence, comprising administering an effective amount of the amino acid sequence to a subject in need. The amino acid sequence can be used to inhibit euptx3 from promoting the migration and invasion of nasopharyngeal carcinoma cells, promoting angiogenesis and inhibiting macrophage phagocytosis to further treat nasopharyngeal carcinoma..
National Cheng Kung University
01/22/15
20150025009
new patent

Collagen and fibrin microthreads in a discrete thread model of in vitro acl scaffold regeneration


Compositions that include fibrin microthreads are provided. The compositions can include one or more therapeutic agents including cytokines and interleukins, extracellular matrix proteins and/or biologically active fragments thereof (e.g., rgd-containing peptides), hormones, vitamins, nucleic acids, chemotherapeutics, antibiotics, and cells.
Worcester Polytechnic Institute
01/22/15
20150025001
new patent

Fish protein hydrolysate having a satietogenic activity, nutraceutical and pharmacological compositions comprising such a hydrolysate and obtaining same


The present invention relates to a fish protein hydrolysate containing molecules capable of exerting a satietogenic activity and of regulating food intake in humans or animals. More specifically, the protein hydrolysate according to the invention enables stimulation of the secretion of endogenous cholescystokinins (ccks) and of endogenous glucagon-like peptide 1 (glp1) molecules by intestinal cells and the supply of exogenous ccks.
Museum National D'histoire
01/22/15
20150024966
new patent

Mesenchymal stem cells for in vitro modeling and cell-based therapy of human diseases and banks thereof


(c) comparing an effect of the first lineage specific cell derived from the subject with an effect of the first lineage specific cell derived from the healthy subject on a second lineage specific cell associated with the brain disease, wherein a difference in the effect above or below a predetermined level is indicative of a qualification of a mesenchymal stem cell population for cell therapy of said brain disease.. .
01/22/15
20150024959
new patent

Method for amplifying cdna derived from trace amount of sample


The problem to be solved by the present invention is to provide a method for preparing a sample for comprehensively and accurately analyzing gene expression in a single cell or a few cells, for example, by a large-scale dna sequencer. The present invention relates to a method for amplifying cdna from mrna in a cell, comprising: (1) capturing mrna derived from the cell by a first dna probe containing a first tag sequence and a poly t sequence and being immobilized to a solid carrier in a single reaction vessel, and synthesizing a first strand cdna from the mrna by a reverse transcription reaction; (2) removing a reaction reagent from the reaction vessel while keeping the first strand cdna synthesized onto the solid carrier in the reaction vessel; (3) adding a polynucleotide sequence consisting of one type of nucleotides to 3′ terminal of the first strand cdna on the solid carrier; (4) hybridizing a second dna probe containing a second tag sequence and a complementary sequence to the polynucleotide sequence with the cdna to which the polynucleotide sequence is added, and synthesizing a second strand cdna; and (5) performing a dna amplification reaction using the second strand cdna synthesized on the solid carrier as a template..
Hitachi, Ltd.
01/22/15
20150024920
new patent

Multi-unit blood processor with temperature sensing


Method and apparatus for centrifugal blood component separation including temperature sensing in each of a plurality of separation cells. The temperature of unit of bloods over time is recorded.
Terumo Bct, Inc.
01/22/15
20150024776
new patent

Optimizing cooperation areas and cover shifts in cellular communications network systems


In a cellular communications network system comprising a plurality of cells including a first cell and second cells different from and present in the neighborhood of the first cell, measurement reports are repeatedly received from user equipments, each including a first signal strength value corresponding to a signal strength measured from the first cell over a short time period and n second signal strength values corresponding to signal strengths measured over the short time period from n second cells, which correspond to the n strongest signal strengths measured from the second cells, n being an integer greater than one. A value of a counter is incremented which corresponds to a potential cooperation area formed by the first cell corresponding to the first signal strength value and the n second cells corresponding to the n second signal strength values..
Nokia Solutions And Networks Oy
01/22/15
20150024766
new patent

Methods and systems for gsm spectrum refarming for lte small cells


One embodiment of the method includes allocating, using a network management entity, at least one of a plurality of physical resource blocks (prbs) of a first wireless access technology for utilization by a second wireless access technology. A spectrum of the first wireless access technology is embedded within a spectrum of the second wireless access technology.
Alcatel Lucent Usa, Inc.
01/22/15
20150024759
new patent

Cell selection techniques for femtocell measurements


User equipment (ue) includes an architecture for handling femtocell fingerprints, and searching for femtocells. The architecture may control the frequencies for which the femtocell search is performed in various manners.
Broadcom Corporation
01/22/15
20150024753
new patent

Neighboring cell measurements


An arrangement (400) for a user equipment, ue, is disclosed. The arrangement (400) comprises an acquiring unit (401) configured to acquire neighboring cell information relating to a plurality of neighboring cells.
St-ericsson Sa
01/22/15
20150024744
new patent

Method for cell selection for narrowband terminal and apparatus using same


Provided are a method for cell selection for a narrowband terminal and an apparatus using same. A narrowband terminal receives a wireless frame comprising a first synchronous signal for a user equipment supporting a first bandwidth, and a second synchronous signal for a user equipment supporting a second bandwidth which is narrower than the first bandwidth.
Lg Electronics Inc.
01/22/15
20150024743
new patent

Cell selection and reselection optimizations responsive to mobility state


User equipment (ue) obtains system information using a foreground or background process. The system information may include cell information that distinguishes femtocells from macrocells.
Broadcom Corporation
01/22/15
20150024742
new patent

Phased search for femtocells


User equipment (ue) includes an architecture for locating femtocells. The architecture implements a phased search approach.
Broadcom Corporation
01/22/15
20150024634
new patent

Wiring module


A wiring module includes first detection terminals for detecting a state of electric cells, and a resin protector that retains the first detection terminals. The first detection terminals each include a first plate-shaped portion having a plate shape, and a first electric wire connecting portion continuous with the first plate-shaped portion and connected to a terminal portion of an electric wire w.
Sumitomo Electric Industries, Ltd.
01/22/15
20150024542
new patent

Segmented thin film solar cells


Use of chemical mechanical polishing (cmp) and/or pure mechanical polishing to separate sub-cells in a thin film solar cell. In one embodiment the cmp is only used to separate the active, thin film layer into sub-cells, with scribing still being used to achieve sub-cell separation in conductive layers above and below the active, thin film layer.
International Business Machines Corporation
01/22/15
20150024541
new patent

Method for fabricating photovoltaic cells with plated contacts


The disclosed technology relates generally to photovoltaic cells, and more particularly to photovoltaic cells with plated metal contacts. In one aspect, a method of fabricating a photovoltaic cell with a metal contact pattern on a surface of a semiconductor substrate includes locally smoothening portions of the surface of the semiconductor substrate by using a first laser, at predetermined locations.
Katholieke Universiteit Leuven, Ku Leuven R&d
01/22/15
20150024539
new patent

Formulation of colloidal titanium-oxide solutions composition for coating and printing methods, and improvement of the output and lifespan of organic p-i-n/n-i-p photovoltaic cells


The invention also relates to a colloidal titanium-oxide nanoparticle solution containing a dispersion of titanium-oxide nanoparticles in a solvent or system of solvents, the viscosity of which is between 4 and 54 cp, said solution being particularly obtainable according to the method of the invention, as well as to the uses thereof, in particular for preparing photovoltaic cells. The invention also relates to a method for generating power using a semiconductor prepared from said solution..
01/22/15
20150024500
new patent

Methods and compositions for producing double allele knock outs


The present invention provides a method and compositions utilizing the crispr system to disrupt a target gene in eukaryotic cells to produce double allele knock outs. The method finds use in producing afucosylated antibodies with enhanced adcc activity..
Larix Bioscience, Llc
01/22/15
20150024498
new patent

Cldn5 mini-promoters


Isolated polynucleotides comprising a cldn5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
The University Of British Columbia
01/22/15
20150024495
new patent

Device and engineering living tissues


A device for assembling aggregations of adherent cells includes a gripper moveable within an assembly vessel that fixes aggregations of adherent cells at a membrane of the gripper and, by movement of the gripper, assembles aggregations of cells on a separate membrane within the vessel, thereby creating a three-dimensional assembly of aggregations of cells that fuse and can be employed in surgical procedures as a unitary tissue of adherent cells. The aggregations of cells, as assembled, can assume three-dimensional configurations distinct from any one of the component aggregations of cells assembled..
Brown University
01/22/15
20150024492
new patent

Cell expansion system and methods of use


Cell expansion systems and methods of use are provided. The cell expansion systems generally include a hollow fiber cell growth chamber, and first and second circulation loops (intracapillary loops and extracapillary loops) associated with the interior of the hollow fibers and exterior of the hollow fibers, respectively.
Terumo Bct, Inc.
01/22/15
20150024489
new patent

Device for enhancing immunostimulatory capabilities of t-cells


T-cells are generated with enhanced immunostimulatory capabilities for use in self therapy treatment protocols, by utilizing a biodegradable device with a biodegradable support that has one or more agents that are reactive to t-cell surface moieties. The biodegradable devices are mixed with the t-cells sufficiently so that the one or more agents cross-link with the t-cells' surface moieties and deliver a signal to the t-cells to enhance immunostimulatory capabilities..
Immunovative Therapies, Ltd.
01/22/15
20150024486
new patent

Embryonic stem cell specific micrornas promote induced pluripotency


The methods of the present application describe that introduction of physiologically relevant mirnas can enhance or modulate somatic cell reprogramming, generating induced pluripotent stem cells (ips cells). These mirnas did not further enhance reprogramming in the presence of cmyc.
The Regents Of The University Of California
01/22/15
20150024485
new patent

Puro-dhfr quadrifunctional marker and its use in protein production


This invention relates to industrial production of proteins. More specifically, the invention relates to the res-dhfr surrogate marker, which corresponds to a fusion between dhfr and a protein conferring resistance to a toxic compound or conferring a metabolic advantage.
Merck Serono Sa
01/22/15
20150024482
new patent

Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer


The present invention provides compositions and methods for generating a genetically modified t cells comprising a chimeric antigen receptor (car) having an antigen binding domain, a transmembrane domain, a costimulatory signaling region, and a cd3 zeta signaling domain, wherein the t cell exhibits prolonged exponential expansion in culture that is ligand independent and independent of the addition of exogenous cytokines or feeder cells.. .
The Trustees Of The University Of Pennsylvania
01/22/15
20150024478
new patent

One-way separator for retaining and recirculating cells


The invention relates to the use of single- or multilayer plastic web plates in a sloped channel-type solid material separator with a lamella package.. .
Mayer Intellectual Property Gmbh
01/22/15
20150024476
new patent

Cell sorting system and methods


Apparatus and methods are provided for a microfabricated fluorescence activated cell sorter based on a switch for rapid, active control of cell routing through a microfluidic channel network. This sorter enables low-stress, highly efficient sorting of populations of small numbers of cells (i.e., 1000-100,000 cells).
Celula, Inc.
01/22/15
20150024469
new patent

Endolysin obpgplys


The present invention relates to a polypeptide with an amino acid sequence according to seq id no: 1 and fragments or derivatives thereof. The present invention further relates to fusion proteins comprising said polypeptide and an additional peptide stretch fused to said polypeptide at the n- or c-terminus.
Katholieke Universiteit Leuven, K.u. Leuven R&d
01/22/15
20150024449
new patent

Process and medium for reducing selenium levels in biomass from fermentation of co-containing gaseous substrates


A process for fermenting syngas and a fermentation medium provides high ethanol productivity while removing medium components that were previously thought to be essential. The process is effective for providing a specific sty of at least about 1 gram of ethanol/(l·day·gram cells) and for providing a selenium content in cell biomass exiting the fermentation of about 1 ppm or less..
Ineos Bio Sa
01/22/15
20150024446
new patent

Methods for improving malic acid production in filamentous fungi


The present invention relates to methods of producing a c4 dicarboxylic acid, comprising: (a) cultivating a filamentous fungal host cell comprising a polynucleotide selected from the group consisting of a heterologous first polynucleotide encoding a c4 dicarboxylic acid transporter, a heterologous second polynucleotide encoding a malate dehydrogenase, and a heterologous third polynucleotide encoding a pyruvate carboxylase; wherein the filamentous fungal host cell is capable of secreting increased levels of the c4 dicarboxylic acid compared to the filamentous fungal host cell without the heterologous polynucleotide when cultivated under the same conditions; and (b) recovering the c4 dicarboxylic acid. The present invention also relates to methods for increasing c4 dicarboxylic acid production, filamentous fungal host cells and malate dehydrogenase variants..
Novozymes, Inc.
01/22/15
20150024440
new patent

Microorganisms for the production of melatonin


Recombinant microbial cells and methods for producing melatonin and related compounds using such cells are described. More specifically, the recombinant microbial cell may comprise exogenous genes encoding one or more of an l-tryptophan hydroxylase, a 5-hydroxy-l-tryptophan decarboxylyase, a serotonin acetyltransferase, an acetylserotonin o-methyltransferase; an l-tryptophan decarboxy-lyase, and a tryptamine-5-hydroxylase, and means for providing tetrahydrobiopterin (thb).
Danmarks Tekniske Universitet
01/22/15
20150024439
new patent

Polypeptides having cellulolytic enhancing activity and nucleic acids encoding same


The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides..
Novozymes, Inc.
01/22/15
20150024438
new patent

Heterologous expression of termite cellulases in yeast


The present invention provides for heterologous expression of termite and termite-associated symbiont cellulases. The cellulases can, for example, be codon-optimized and expressed in yeast host cells, such as the yeast saccharomyces cerevisiae.
Mascoma Corporation
01/22/15
20150024434
new patent

Method for obtaining fab fragments from single antibody producing cells by multiplexed cpr in combination with taqman probes


Herein is reported a method for a multiplex one tube real-time reverse-transcriptase gene-specific polymerase chain reaction for the amplification and quantification of cognate igg heavy and light chains encoding nucleic acids (human igg isotype) from a single cell.. .
Hoffmann-la Roche Inc.
01/22/15
20150024421
new patent

Number of il4 and/or il13 secreting t-cells as a biomarker for allergic diseases


The present invention relates to an in vitro use of a number of il-4 and/or il-13 secreting t-cells as a biomarker for diagnosing and/or monitoring an ige-dependent allergic disease.. .
Universite Pierre Et Marie Curie - Paris 6
01/22/15
20150024412
new patent

Humanized fcgammar mice


Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity fcγr locus, and wherein the mouse is capable of expressing a functional fcrγ-chain. Genetically modified mice are described, including mice that express low affinity human fcγr genes from the endogenous fcγr locus, and wherein the mice comprise a functional fcrγ-chain.
Regeneron Pharmaceuticals, Inc.
01/22/15
20150024411
new patent

Chromatographic isolation of cells and other complex biological materials


The present invention relates to the chromatographic isolation of a target cell or another complex biological material, in particular by column chromatography such as affinity chromatography or gel permeation chromatography. The invention employs a receptor binding reagent that binds to a receptor molecule that is located on the surface of a target cell.
Stage Cell Therapeutics Gmbh
01/22/15
20150024409
new patent

Methods and systems for predicting drug-response


Disclosed herein are methods and systems for determining whether a cell is resistant to one or more drugs. Also, disclosed herein are methods and systems for monitoring the treatment of a cancer patient to determine whether the cancerous cells being treated are resistant to the treatment.
01/22/15
20150024406
new patent

Increased aquaporin expression on cellular membrane to improve cryopreservation efficiency


A method of storing mammalian cells or tissue (e.g., liver cells or hepatocytes) for subsequent use comprises the steps of: (a) contacting the cells or tissue in vitro to a choleretic agent in an effective amount; (b) combining said cells or tissue with a cryopreservative; (c) freezing said cells or tissue, and then (d) storing said frozen cells or tissue in frozen form for subsequent use.. .
01/22/15
20150024403
new patent

Method for detecting replication or colonization of a biological therapeutic


Methods for detecting replication in or colonization of a host by a biological therapeutic, such as an oncolytic virus, cells administered for cell therapy and gene therapy vectors, are provided. In the methods, a product produced by the biological therapeutic is detected in a sample of tissue or body fluid distinct from the administered therapy or locus thereof, thereby permitting assessment of the therapy and/or monitoring its progress..
01/22/15
20150024395
new patent

Method and system for automated image analysis in cancer cells


A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes directed to at least one chromosomal sequence that characterizes the abnormality under conditions that promote hybridization of the one or more probes to the at least one sequence, automatically obtaining a representation of the one or more distinguishable labels hybridized to the chromosomal sequences, automatically analyzing the distribution and intensity of binding of the one or more labels in the representation to determine the presence and/or extent of an abnormal chromosomal component; and automatically reporting results of the analysis; wherein the steps are carried out without intervention by a human.. .
Neodiagnostix Inc
01/22/15
20150024394
new patent

Method and system for automated image analysis in cancer cells


A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes directed to at least one chromosomal sequence that characterizes the abnormality under conditions that promote hybridization of the one or more probes to the at least one sequence, automatically obtaining a representation of the one or more distinguishable labels hybridized to the chromosomal sequences, automatically analyzing the distribution and intensity of binding of the one or more labels in the representation to determine the presence and/or extent of an abnormal chromosomal component; and automatically reporting results of the analysis; wherein the steps are carried out without intervention by a human.. .
Neodiagnostix, Inc.
01/22/15
20150024393
new patent

Method and system for automated image analysis in cancer cells


A method of screening for the presence and/or extent of a pathology in a subject, the pathology characterized by an abnormal chromosomal component in a cell of the subject, comprising the steps of: contacting a biological sample comprising cell nuclei from said subject with, one or more distinguishable labeled probes directed to at least one chromosomal sequence that characterizes the abnormality under conditions that promote hybridization of the one or more probes to the at least one sequence, automatically obtaining a representation of the one or more distinguishable labels hybridized to the chromosomal sequences, automatically analyzing the distribution and intensity of binding of the one or more labels in the representation to determine the presence and/or extent of an abnormal chromosomal component; and automatically reporting results of the analysis; wherein the steps are carried out without intervention by a human.. .
Neodiagnostix Inc
01/22/15
20150024389
new patent

Method for detecting bladder cancer cells, primer used in detecting bladder cancer cells, and bladder cancer marker


Provided are: a method for detecting bladder cancer with high detection sensitivity, which has a high specificity for bladder cancer and is capable of detecting bladder cancer tissues with low grade of malignancy; and a bladder cancer marker. A method for detecting bladder cancer cells, which comprises detection of the amount of expressed bladder cancer marker in a subject sample collected from a subject, said bladder cancer marker being composed of one or more mirnas selected from among mir-124, mir-9 and mir-137; a primer which is used in the method for detecting bladder cancer cells; and a bladder cancer marker..
Lsip, Llc
01/22/15
20150024298
new patent

System and tuning an electrochemical cell stack


The present disclosure is directed to a method for tuning the performance of at least one electrochemical cell of an electrochemical cell stack. The method includes supplying power to an electrochemical cell stack.
Nuvera Fuel Cells, Inc.
01/22/15
20150024290
new patent

Metal-air button cells and manufacturing the same


Metal-air button cells including a closed cell housing and, arranged therein, an air cathode and a metal-based anode separated from one another by a separator, wherein the cell housing is substantially composed of a first housing half-part and a second housing half-part; the housing half-parts are configured to be cup-shaped and have a base and a circumferential side wall; the base of the second housing half-part has one or more entry and/or exit openings for atmospheric oxygen; and the air cathode is configured to be disc-shaped and is positioned on the base of the second housing half-part such that it covers the entry and/or exit openings and its periphery bears on the inner side of the circumferential side wall of the second housing half-part.. .
Varta Microbattery Gmbh
01/22/15
20150024288
new patent

Assembled battery


An assembled battery includes a plurality of air cells arranged in a horizontal direction and a plurality of connection flow paths. Each air cell includes a storage portion between a positive electrode and a metal negative electrode to store an electrolysis solution.
Nissan Motor Co., Ltd.
01/22/15
20150024285
new patent

Mini-fuel cells for battery-powered devices


Mini-fuel cells for small devices.. .
01/22/15
20150024279
new patent

Semi-solid electrodes with gel polymer additive


Embodiments described herein relate generally to electrochemical cells having semi-solid electrodes that include a gel polymer additive such that the electrodes demonstrate longer cycle life while significantly retaining the electronic performance of the electrodes and the electrochemical cells formed therefrom. In some embodiments, a semi-solid electrode can include about 20% to about 75% by volume of an active material, about 0.5% to about 25% by volume of a conductive material, and about 20% to about 70% by volume of an electrolyte.
24m Technologies, Inc.
01/22/15
20150024268
new patent

Hydrocarbon ionomer compositions, layerings, electrodes, methods for making and methods for using


There is a composition comprising 1 to 17.5 wt. % ionomer composition comprising hydrocarbon ionomer and 50 to 99 wt.
E I Du Pont De Nemours And Company
01/22/15
20150024261
new patent

Battery cell for secondary batteries


Provided is a battery cell for a secondary battery, and more particularly, a battery cell for a secondary battery basically including an electrode plate, a case, and electrode tabs. According to the battery cell for the secondary battery in the present invention, since a plurality of battery cells are electrically connected to each other only with a structure of the electrode tabs, a separate component for connection of the electrode tabs is not required, such that it is easy to secure a space at the time of manufacturing a battery pack.
Sk Innovation Co., Ltd.
01/22/15
20150024253
new patent

Battery pack


Provided is a battery pack including a pair of end plates facing each other, a plurality of battery cells arrayed between the end plates, and a pair of side plates each extending along a length of the plurality of battery cells, and coupled to the end plates, wherein each of the end plates includes a base plate, bending portions bent from each edge of the base plate in a direction away from the plurality of battery cells, each bending portion having a reinforcing bead unit, and a flange portion connected to the base plate at each bending portion. According to one or more embodiments of the present invention, deformation of the battery pack may be efficiently suppressed and deterioration of a function of a battery cell may be prevented by blocking volume expansion due to recharging and discharging operations of the battery cell..
Samsung Sdi Co., Ltd.
01/22/15
20150024252
new patent

Battery module of improved stability


Disclosed herein is a battery module including a plurality of battery cells, the battery module including the battery cells being stacked in a state in which electrode terminals are electrically connected to each other, a pair of cell covers coupled to each other to surround the entirety of an outside of a battery cell stack including two or more battery cells excluding the electrode terminals of the battery cells, and fixing members mounted at the cell covers in contact with the outside of the battery cell stack to properly fix the battery cells in the cell covers.. .
Lg Chem, Ltd.
01/22/15
20150024251
new patent

Protected active metal electrode and battery cell structures with non-aqueous interlayer architecture


Active metal and active metal intercalation electrode structures and battery cells having ionically conductive protective architecture including an active metal (e.g., lithium) conductive impervious layer separated from the electrode (anode) by a porous separator impregnated with a non-aqueous electrolyte (anolyte). This protective architecture prevents the active metal from deleterious reaction with the environment on the other (cathode) side of the impervious layer, which may include aqueous or non-aqueous liquid electrolytes (catholytes) and/or a variety of electrochemically active materials, including liquid, solid and gaseous oxidizers.
Polyplus Battery Company
01/22/15
20150024246
new patent

Battery assembly with temperature control device


A battery module of the present invention is adaptable to be utilized in various configurations including and not limited to an overlapping battery cell packaging configuration and a vertical stack battery cell packaging configuration used in an automotive and non-automotive applications. The battery module has a plurality of battery heatsink assemblies with the cells disposed therebetween.
Enerdel, Inc.
01/22/15
20150024242
new patent

Battery monitoring device and a battery unit


A battery monitoring device includes a first unit arranged outside a plurality of stacks each of which includes cells; a plurality of second units arranged in each of the stacks to output voltage data of the cells; a signal line that connects the second units and the first unit in a daisy chain mode; and a detection unit that detects a stack voltage wherein the first unit determines that a disconnection is generated on the signal line when a response is not received from the plurality of second units via the signal line after sending data is sent to the plurality of second units via the signal line and, determines on which path of the signal line, a forward path or a backward path, the disconnection is generated based on a difference between the stack voltage and a total of all detected output voltages sent from the second units.. .
Toyota Jidosha Kabushiki Kaisha
01/22/15
20150024240
new patent

Exchangeable energy storage device


The invention relates to an energy storage device (1) having storage modules (3) which are connected in series in a supply section and which in each case comprises an energy storage cell module (5) having at least one energy storage cell (5a, 5k) and a coupling device (7) having coupling elements (7a, 7b, 7c, 7d) which are designed selectively to switch the energy storage cell module (5) into the supply section or to bridge said energy storage cell module. The energy storage cells or the energy storage cell modules can be exchanged..
Robert Bosch Gmbh
01/22/15
20150024239
new patent

Cover for batteries


A battery module comprises a plurality of electrically interconnected battery cells, a module cover, and a battery cell monitoring unit. The battery cells include at least one terminal cover.
Samsung Sdi Co., Ltd.
01/22/15
20150024065
new patent

Treatment of retroviral reservoirs exploiting oxidative stress


Activation of hiv-1 replication causes oxidative stress, which in turn potentiates hiv-1 replication. The common basis for the compounds of the present invention is: a) the capacity of reactivating hiv-1 from latency, and b) the ability to counteract the cellular machinery which activates in order to limit the effects of oxidative stress.
Istituto Superiore Di Sanita
01/22/15
20150024036
new patent

Targeting rnas to microvesicles


Disclosed herein is an isolated nucleic acid molecule comprising a first nucleic acid sequence 5′-accctgccgcctggactccgcctgt-3′ (seq id no: 22), or a functional variant thereof, operably linked to a second, heterologous nucleic acid sequence. The isolated nucleic acid molecule can be dna (in an expression vector) and rna (mrna, shrna, orncrna).
The General Hospital Corporation
01/22/15
20150024026
new patent

Scaffolds for cell transplantation


A device that includes a scaffold composition and a bioactive composition with the bioactive composition being incorporated into or coated onto the scaffold composition such that the scaffold composition and/or a bioactive composition controls egress of a resident cell or progeny thereof. The devices mediate active recruitment, modification, and release of host cells from the material..
President And Fellows Of Harvard College
01/22/15
20150024024
new patent

Cell lines that produce prostaglandin f2 alpha (pgf2a) and uses thereof


Cells and cell lines that are genetically modified to express the hcox-2 enzyme, which results in the upregulation of prostaglandin f2 alpha (pgf2a) on the cells have been obtained. Encapsulated cell therapy devices containing such cells or cell lines that are capable of delivering pgf2a, as well as methods of using these devices to deliver pgf2a to the eye and to treat ophthalmic disorders in patients suffering therefrom are also described..
Neurotech Usa, Inc.
01/22/15
20150024008
new patent

Methods and compositions involving induced senescent cells for cancer treatment


Disclosed are cancer vaccines comprising senescent cells and methods of using and preparing the vaccines.. .
The University Of Chicago
01/22/15
20150024006
new patent

Allogeneic cellular immunotherapy for opportunistic infection


A method for stimulating the immune system in immunocompromised patients in order to treat opportunistic infection. The method involves the infusion of intentionally mismatched allogeneic cells.
Immunovative Therapies, Ltd.


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