|| List of recent Cells-related patents
| Chimeric promoters capable of mediating gene expression in plants upon pathogen infection and uses thereof|
Described are synthetic promoters capable of mediating gene expression in plants upon pathogen infection. Furthermore, recombinant genes and vectors comprising said chimeric promoters as well as host cells transformed with such chimeric promoters, recombinant genes, or vectors are provided.
| Use of aldh7 for improved stress tolerance|
The present invention relates to the field of plant molecular biology, more particularly to the regulation of genes that increase drought tolerance and yield. Provided herein are methods finding use in agriculture for increasing drought tolerance in dicot and monocot plants.
| Stress responsive expression|
The present invention relates to the identification of transcriptional control sequences that are active in plants in response to stress. Accordingly, methods for effecting stress responsive expression of a nucleotide sequence of interest in a plant are provided, the methods including expressing the nucleotide sequence of interest operably connected to a transcriptional control sequence which is stress inducible in the plant, wherein the nucleotide sequence of interest is heterologous with respect to the transcriptional control sequence.
| Variety corn line id3517|
The present invention provides an inbred corn line designated id3517, methods for producing a corn plant by crossing plants of the inbred line id3517 with plants of another corn plant. The invention further encompasses all parts of inbred corn line id3517, including culturable cells.
| Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription|
The present disclosure provides a dna-targeting rna that comprises a targeting sequence and, together with a modifying polypeptide, provides for site-specific modification of a target dna and/or a polypeptide associated with the target dna. The present disclosure further provides site-specific modifying polypeptides.
| Methods for genetic diversification in gene conversion active cells|
The invention relates to a modified lymphoid cell having gene conversion fully or partially replaced by hypermutation, wherein said cell has no deleterious mutations in genes encoding paralogues and analogues of the rad51 protein, and wherein said cell is capable of directed and selective genetic diversification of a target nucleic acid by hypermutation or a combination of hypermutation and gene conversion. The invention also relates to a method for diversifying any transgenic target gene in said cell.
| R2r1/2 in diagnosis and therapy|
The present invention stems from the finding that two genes designated r2r1 and r2r2, play important roles in tissue development and cancer biology. In particular, the inventors have discovered that these two genes are expressed in pulmonary cells and are required for late branching morphogenesis of pulmonary epithelium and endothelium and support the development/maintenance of the refined three dimensional architecture of the lung.
| Non-transitory computer readable medium storing timing analysis program, timing analysis device, and timing analysis method|
A timing analysis device includes a storage unit and a processing unit. The processing unit performs storage processing and analysis processing.
| Cell view mode for outsized cells|
Embodiments provide electronic spreadsheet viewing and interaction features and functionalities, but the embodiments are not so limited. In an embodiment, a computer-implemented method can be configured to provide a cell view launch indicator or interface that alerts a user that a selected cell includes additional content not being currently displayed.
| Memory system|
According to one embodiment, a memory module which includes a plurality of nonvolatile memory cells with a plurality of pages and line-and-space word lines to which more than one of the memory cells are connected, and a controller which receives write data from a host device.. .
| Semiconductor memory device and method of operating the same|
Semiconductor memory device and method of operating same includes reading data stored in memory cells of a page; performing an error correction loop (ecc loop) including performing an error checking and correcting operation (ecc) on the read data; determining a number of bit errors in the read data; and when the number of bit errors is greater than a maximum number of correctable bits, incrementing the number of ecc iterations (ecc count) and increasing the maximum number of correctable bits; storing the ecc count until the number of bit errors is less than the maximum number of correctable bits; and programming corrected data to the memory cells when the stored ecc count is more than preset number.. .
| Semiconductor test system and method|
A test controller applies test stimulus signals to the input pads of plural die on a wafer in parallel. The test controller also applies encoded test response signals to the output pads of the plural die in parallel.
| Systems and methods for implementing persistent battery shutdown for information handling systems|
Systems and methods are provided for implementing a persistent battery system shutdown condition when a battery pack voltage level drops below a predetermined minimum acceptable operating voltage threshold that is above a pre-determined permanent failure operating voltage threshold at which the battery pack is permanently disabled. The disclosed systems and methods may be implemented such that shutdown portion of the power-consuming components of the information handling system are not allowed to be restarted until external power has been first provided and applied to at least partially recharge the battery cells of the battery pack to a battery voltage level that is above the minimum acceptable operating voltage threshold and/or when sufficient external power is applied to power the information handling system and at the same time charge the battery cells of the battery pack..
| Memory device, memory system including the same, and method for operating the memory system|
A memory device includes a non-volatile memory configured to store a repair data and output the repair data in response to an initialization signal, a plurality of registers configured to store the repair data outputted from the non-volatile memory, a plurality of memory banks configured to replace normal cells with redundant cells by using the repair data stored in corresponding registers among the plurality of registers, a verification circuit configured to generate a completion signal for informing that transfer of the repair data from the non-volatile memory to the plurality of registers is completed, and an output circuit configured to output the completion signal to a device other than the memory device.. .
| Memory device for reducing a write fail, a system including the same, and a method thereof|
A memory system includes a memory device and a memory controller. The memory device includes a plurality of memory cells.
| Methods and apparatus for designating or using data status indicators|
Memory devices and methods facilitate handling of data received by a memory device through the use of data grouping and assignment of data validity status values to grouped data. For example, data is received and delineated into one or more data groups and a data validity status is associated with each data group.
| Memory controller, method of operating memory controller, and system comprising memory controller|
A memory controller controls operation of a nonvolatile memory device comprising a memory area comprising a plurality of multi-level cells (mlcs). The memory controller receives an address of the memory area and data to be programmed to the memory area, analyzes access history information regarding the memory area based on the address, generates first mapping data corresponding to the data or second mapping data based on the data and previous mapping data that has been programmed to the mlcs according to a result of the analysis, and transmits a program command comprising one of the first mapping data and the second mapping data to the nonvolatile memory device..
| Level placement in solid-state memory|
Methods and apparatus are provided for determining level placement in q-level cells of solid-state memory, where q>2. Groups of the cells are programmed to respective levels of a predetermined plurality of programming levels, and each cell is then read at a series of time instants to obtain a sequence of read metric values for that cell.
| Method for determination of performance of an accumulator-unit|
The disclosure relates to a method for determination of a maximum allowable load current of an energy storage cell by means of a substitute model. The parameters of the substitute model are adapted during the lifetime of the energy storage cell.
| Battery thermal system and diagnostic method|
A system includes a battery pack having a fluid inlet, a fluid outlet, and battery cells. The system also includes a thermal system having heat transfer fluid, a flow device, an inlet thermocouple, one or more internal thermocouples connected to a respective one of the battery cells, and a controller.
| Variable product agrochemicals application management|
Methods and products are provided for facilitating application of variable-product agrochemicals, such as fertilizer, to an application area, such as a field. The fertilizer or agrochemical may include a single fertilizer or agrochemical type or a mixture.
| Crush recoverable polymer scaffolds|
A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%.
| System for treating lipid-rich regions|
A system is described for removing heat from a subject's subcutaneous lipid-rich regions, such as tissues, organs, cells, and so forth. In various embodiments, the system includes a controller, a computing device, a data acquisition device, a chiller, and one or more applicators.
| Ablation device and method for electroporating tissue cells|
A method and system for producing deep lesions without the production of high heat. The method generally includes ablating target tissue cells with a device in communication with an energy generator programmable to ablate tissue using heat energy, electroporation, or a combination thereof.
| Method of tracking specific cells in vivo|
A method of tracking specific cells in vivo is disclosed. The method of the disclosure includes: providing fluorescent nanoparticles suitable for targeting of specific cells; administering the fluorescent nanoparticles to a subject; providing an x-ray source to irradiate the subject; and determining the distribution and growth of the specific cells by the fluorescent images from the fluorescent nanoparticles and x-ray images of the subject irradiated by the x-ray source..
| Olefin hydration process using oscillatory baffled reactor|
A butanol production system and method of producing refined mixed butanols from water and mixed butenes. The system includes an internal baffle single pass reactor, a separation system and an exterior motion driver.
| Methods and compositions for the treatment of cancer or other diseases|
The present invention relates to methods and compositions for the treatment of diseases, including cancer, infectious diseases and autoimmune diseases. The present invention also relates to methods and compositions for improving immune function.
| Method of activating regulatory t cells with alpha-2b adrenergic receptor agonists|
Disclosed herein is a method of upregulating regulatory t-cells, and treating diseases that would benefit from such upregulation, by administering an alpha 2 receptor agonist.. .
| Methods and materials for assessing responsiveness to lenalidomide, thalidomide, and/or other thalidomide analogs|
This document provides methods and materials related to assessing responsiveness to lenalidomide, thalidomide, and/or other imids (structural and functional analogues of thalidomide that represent a promising new class of immunomodulators). For example, methods and materials for using crbn levels to determine whether or not cancer cells (e.g., multiple myeloma cells) are susceptible to lenalidomide, thalidomide, and/or other imids are provided..
| Methods of diagnosing and treating cancer|
A method of determining the susceptibility of a cancer in a subject to treatment with an antimetabolite includes obtaining a sample of cancer cells from the subject, measuring the level of udg expression in the cancer cells, and comparing the measured levels of udg expression in the cancer cells to a control level.. .
| Methods for treating vascular leak syndrome|
Disclosed are methods for treating vascular leak syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease.
| Dipyridinium derivatives|
Compounds of formula (i): α-x-β (i) and pharmaceutically acceptable salts and solvates thereof, wherein α, x, and β have the meanings as indicated in the specification, are useful for treating a disease or disorder characterised by pathologically proliferating cells, particularly cancer. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described..
| Pharmaceutical composition containing an endocytic motif and protein transduction domains for preventing or treating cancer|
The present invention relates to a novel endocytic motif, and in particular, to a fusion polypeptide including the motif represented by an amino acid sequence of seq id no. 1 and a protein transduction domain, a pharmaceutical composition for preventing or treating cancer including the same, and a method for treating cancer including the step of administering the composition.
| Simultaneous delivery of receptors and/or co-receptors for growth factor stability and activity|
The compositions and methods of the present invention relate to the co-delivery of a molecule and a polypeptide to cells to improve the therapeutic efficacy of the molecules. In one embodiment of the invention, the invention may improve delivery of growth factors by co-delivering these growth factors with their receptors and co-receptors, such as syndecans.
| Subcutaneous delivery of a long-acting natriuretic peptide|
This document provides methods and material related to natriuretic polypeptides. For example, substantially pure polypeptides having a natriuretic peptide activity, nucleic acids encoding polypeptides having a natriuretic peptide activity, host cells containing such nucleic acids, and methods for inducing a natriuretic or diuretic activity within a mammal are provided..
| Use of histones for the early diagnosis and/or preventive therapy of virally-infected living cells|
There is provided a biologically-active agent, in particular, for the early diagnosis and/or preventative therapy of virally-infected living cells, the efficacy of which is selective for the cell membranes of the virally-infected cells, which are modified after viral infection. The agent includes at least one component, selected from a group of materials, including recombinant human histone h1 or at least an h1 subtype or the active portion thereof.
| Game machine, and control method of controlling computer and computer program used therefor|
A game machine includes a display device that displays a game screen in which virtual reels formed by symbols are arranged so as to correspond one-to-one to cells as symbol stop positions. And, a game machine determines the symbol to stop in each cell through drawing, and controls a movement to change the symbol and a stop of the movement for each virtual reel based on a drawing result.
| Method and arrangement of performing neighboring cell measurements|
A method is disclosed for a user equipment having first and second radio access technology capability and registered in a first cell employing the first radio access technology. The method comprises acquiring a neighboring cell list comprising information relating to one or more first neighboring cells employing the second radio access technology, the one or more first neighboring cells being associated with the first cell.
| Small cell service delivery platform usage compliance|
Embodiments of the disclosed invention include an apparatus, method, and computer program product for managing cellular usage in controlled areas. For example, in one embodiment, a method executed by a cellular monitoring system for managing cellular usage in a controlled area is disclosed that includes the steps of configuring a size of the controlled area by varying the signal strengths associated with the one or more small cells; identifying a cellular device within signal range of one or more small cells placed in the controlled area; determining whether the cellular device is an authorized device within the controlled area; and alerting security personnel in response to determination that the cellular device is not an authorized device within the controlled area..
| Battery conservation in stationary conditions for a wireless device|
Conserving battery by a wireless user equipment (ue) device in substantially stationary conditions. A first wireless link may be established with a first cell.
| Apparatus and method for providing a relayed wireless communication path between cells|
A first apparatus at a first base station changes directivity of a first antenna connected in a direction of a cell of a second base station adjacent to the first base station, where directivity of some antennas of a second apparatus at the second base station is changed to a cell of the first base station and some radio resources are assigned to wireless communication with the first apparatus. The first apparatus receives a signal of a first frequency from the second apparatus via the first antenna, converts the received signal into a signal of a second frequency, demodulates the signal of the second frequency, corrects a delay of the demodulated signal caused by propagation of a radio wave and frequency conversion, and modulates the corrected signal to a signal of a third frequency which is transmitted to a cell of the first base station via a second antenna..
| Battery wiring module|
A battery wiring module is configured for attachment to an electric cell group constituted by an array of a plurality of electric cells, each having positive and negative electrode terminals. The battery wiring module includes a bus bar connectable to the electrode terminals, a detection wire for detecting a state of the electric cell group, a resin protector for holding the bus bar, a lid portion that covers the bus bar and is made of an insulating material, and at least one wall portion disposed on a face of the lid portion opposite to the bus bar in a direction intersecting the lid portion.
| Cover for protecting solar cells during fabrication|
A removable cover system for protecting solar cells from exposure to moisture during fabrication processes. The cover system includes a cover having a configuration that complements the configuration of a solar cell substrate to be processed in an apparatus where moisture is present.
| Uniformly distributed self-assembled solder dot formation for high efficiency solar cells|
A method for fabricating a photovoltaic device includes performing a gettering process in a processing chamber which restricts formation of a layer of gettering materials on a substrate and forming a solder layer on the substrate. The solder layer is annealed to form uniformly distributed solder dots which grow on the substrate.
| Method and device for producing solar cell strings|
A method and an apparatus for producing solar cell strings by connecting at least two solar cells by a least one conductor ribbon of a first length, wherein the solar cells are respectively spaced from one another at a string cell spacing(s), until a desired number of solar cells for producing a first solar cell string is connected together, connecting a further solar cell with a last solar cell of the first solar string by at least another conductor ribbon which is longer than the at least one conductor ribbon, wherein the second solar cell is spaced from the last solar cell at a greater spacing than the string cell spacing(s) and wherein the second solar cell forms the first solar cell for a second solar string, and separating the at least another conductor ribbon for decoupling the first solar cell string.. .
| Small molecule-dependent inteins and uses thereof|
Elucidating the function of proteins in mammalian cells is particularly challenging due to the inherent complexity of these systems. Methods to study protein function in living cells ideally perturb the activity of only the protein of interest but otherwise maintain the natural state of the host cell or organism.
| Methods to control protein heterogeneity|
The instant invention relates to the field of protein production, and in particular to compositions and processes for controlling and limiting the heterogeneity of proteins expressed in host cells.. .
| Multilayered cell culture apparatus|
A multilayered cell culture apparatus for the culturing of cells is disclosed. The cell culture apparatus is defined as an integral structure having a plurality of cell culture chambers in combination with tracheal space(s).
| Materials and methods for mobilizing cells including cd34+, hematopoietic colony forming, and endothelial colony forming cells|
Disclosed herein are materials and methods such as the use of none steroidal anti-inflammatory drugs to increase the number of cd34+ cell in human patients. The level of ecfc measured in volunteers before and after treatment with meloxicam.
| Cell collection system|
The present invention provides a simple and highly reliable cell collection system with high throughput and improved in cell collection efficiency. In the present invention, one or more pores are formed in a cell collection plate.
| Recombinant microorganisms and uses therefor|
A stereospecific enzyme in c. Autoethanogenum permits the conversion of racemic propanediol to acetone and/or propionaldehyde.
| Cells and methods for producing isobutyric acid|
Disclosed herein are cells and methods for renewably producing isobutyrate. In some cases, the cells can include a heterologous dna that encodes at least one enzyme that catalyzes the conversion of isobutyraldehyde to isobutyrate.
| Enhanced tumor therapy by tumor stem cell targeted oncolytic viruses|
The invention relates to recombinant oncolytic viruses that target tumor stem cells and various uses of these recombinant viruses. In particular, an oncolytic virus comprising a recombinant binding domain specific for a tumor stem cell marker is disclosed.
| Compositions and methods for 3-hydroxypropionic acid production|
The present application discloses genetically modified yeast cells comprising an active 3-hp fermentation pathway, and the use of these cells to produce 3-hp.. .
| Novel glycoside hydrolases from thermophlic fungi|
The present invention relates to isolated polypeptides having cellulolytic activity or hemicellulolytic activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
| Separatome-based protein expression and purification platform|
Provided is a separatome-based recombinant peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome, such as that of e. Coli, yeast, bacillus subtilis or other prokaryotes, insect cells, mammalian cells, etc.
| Polypeptides having cellobiohydrolase activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having cellobiohydrolase activity, catalytic domains, and cellulose binding domains and polynucleotides encoding the polypeptides, catalytic domains, and cellulose binding domains. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides, catalytic domains, or cellulose binding domains..
| Neuroblastoma host cell line for stably expressing human exogenous protein and method|
A neuroblastoma host cell line for stably expressing human exogenous protein is provided. The cell line is generated by independently integrating control plasmid and switch plasmid into genome of human neuroblastoma sh-sy5y cells.
| Cldn5 mini-promoters|
Isolated polynucleotides comprising a cldn5 mini-promoter are provided. The mini-promoter may be operably linked to an expressible sequence, e.g.
| Method and system for analyzing a blood sample|
Methods, systems, and computer program products for the analysis of a blood sample are disclosed. One embodiment is a method of detecting and enumerating hard-to-ghost cells in a blood sample.
| Microfluidic biological barrier model and associated method|
A biological barrier model is disclosed. In some embodiments the barrier may be configured to model the blood brain barrier.
| Culture method, group of mature adipocytes, drug screening method|
In a culture method for adipocytes, seeded adipocytes are cultured while being allowed to adhere to a culture bottom surface (14) and walls (12) disposed perpendicularly to the culture bottom surface (14), without suspending the adipocytes in a culture solution, thereby obtaining mature adipocytes in which spherical lipid droplets having increased in size are generated within cells. This method uses a culture chamber (10) in which the walls (12) are formed perpendicular to the culture bottom surface (14).
| Cardiomyocytes-containing device and method for manufacturing and using the same|
A method for developing a disease model for a disease that is caused by or modified by stretching of cells, in particular a cardiac disease model uses a device for determining the cardiotoxicity of a chemical compound, comprising a substrate (10) carrying a deformable stack (34), said stack being partially detached from the substrate by a cavity (32) allowing an out-of-plane deformation of the stack, said stack comprising a first deformable layer (16), a second deformable layer (20) and a multi-electrode structure (18) sandwiched between the first and second deformable layers, the second deformable layer carrying a pattern of cardiomyocytes (28) adhered thereto; and a liquid container (26) mounted on the substrate for exposing the cardiomyocytes to the chemical compound. A method of manufacturing such a device is also disclosed..
| Screening method for substance acting on maintenance of epithelial properties of cell|
A screening method for a substance acting on a maintenance of the epithelial properties of cells which enables obtainment of highly-reliable data quickly at low costs is provided. The screening method includes (a) a step for culturing cells on a cell culture substrate that can form a spheroid, (b) a step for causing the cells to contact a test substance, and (c) a step for evaluating an effect of the test substance acting on a maintenance of the epithelial properties of the cells with a change in a morphology of the spheroid being as an indicator.
| Method of therapy|
Numerous diseases have been linked to the production of regulator cells. The present invention relates to the observation that the immune system is cycling in these diseases.
| Method of analyzing image of cell in laminated structure and method of evaluating laminated structure for corneal transplantation|
A method of analyzing an image of a cell in a laminated structure may include the steps of: (a) fluorescently labeling a cell nucleus in the laminated structure having at least one cell layer and one or more other types of biomolecules; (b) acquiring a plurality of planar tomographic fluorescent labeled images in different height directions from the laminated structure for each type of fluorescently labeled biomolecules after the step (a); (c) superimposing a planar tomographic fluorescent labeled image group acquired in the step (b) to construct a three-dimensional tomographic image; (d) dividing the three-dimensional tomographic image constructed in the step (c) into one or two or more cell regions; (e) producing one planar stacked image for each divided cell region after the step (d); and (f) performing image analysis on each planar stacked image produced in the step (e) to analyze cells in the laminated structure.. .
| Determining information for cells|
Systems, methods, and devices for determining information for cells are provided. The systems, methods, and devices are configured such that information for more than 100,000 cells can be determined in a single run.
| Methods for determining the effects of compounds on jak/stat activity|
An embodiment of the present invention is a method for subjecting a hematopoetic cell to a jak/stat inhibitor, determining the activity of gain-of-function mutations of a jak family kinase, determining the expression levels and activity of jak/stat regulatory proteins, correlating the expression levels and the activity of jak/stat regulatory proteins with the activity of gain-of-function mutations of a jak family kinase and with a response to the jak/stat inhibitor, and then classifying the cells. A further embodiment of the invention includes determining the clinical outcome based on the cell classification, determining a method of treatment, determining dosing and scheduling of at least one of the jak/stat inhibitors or other compounds..
| Methods of treating diseases|
In one example, the present invention comprises deliberate tumor insult and sequencing of the t cell repertoire before and after the insult in order to detect and sequence the tcr alpha and beta loci of highly expanded t cell clonotypes. In some examples, this information is used in turn to create autologous genetically engineered t cells with tcr sequences that target the individual's tumor..
| Compositions and methods for biological sample storage|
Compositions and methods are disclosed for substantially dry storage at ambient or elevated temperatures of biological samples such as nucleic acids, proteins and cells in a form from which the samples can be substantially recovered, using a dissolvable or dissociable dry storage matrix comprising a borate composition and a stabilizer as disclosed, such as any of a number of zwitterionic stabilizers.. .
| Isotopically-labeled proteome standards|
The invention provides methods for quantifying biomolecules, such as polypeptides in mass spectrometric analysis. The methods include use of a biomolecule standard having at least one atomic isotope different than that of the naturally occurring isotopes in the biomolecule of interest.
| Isoltation of factors associated with nucleic acid|
Methods for screening and isolating peptide, polypeptide, protein complexes and non-coding nucleic acids that are associated with selected target genomic locus are provided. The methods comprise the steps of obtaining a sample that comprises a modified target genomic dna sequence and one or more peptide, polypeptide, protein complexes and non-coding nucleic acids as with that dna sequence.
| Method for in vitro detecting keratin gene fusion of squamous-cell cancer|
A method for in vitro detecting keratin gene fusion of squamous-cell cancer comprises steps: (a) obtaining a sample of squamous cells from a testee; and (b) detecting whether the sample of squamous cells has gene fusion, which is likely to occur in squamous-cell cancer and unlikely to occur in healthy tissue. The sample of squamous cells is determined to have squamous-cell cancer if the gene fusion exists in the sample of squamous cells..
| Method for the enumeration of mammalian micronucleated erythrocyte populations, while distinguishing platelets and/or platelet-associated aggregates|
A method for the enumeration of micronucleated erythrocyte populations while distinguishing platelet and platelet-associated aggregates involves the use of a first fluorescent labeled antibody having binding specificity for a surface marker for reticulocytes, a second fluorescent labeled antibody having binding specificity for a surface marker for platelets, and a nucleic acid staining dye that stains dna (micronuclei) in erythrocyte populations. Because the fluorescent emission spectra of the first and second fluorescent labeled antibodies do not substantially overlap with one another or with the emission spectra of the nucleic acid staining dye, upon excitation of the labels and dye it is possible to detect the fluorescent emission and light scatter produced by the erythrocyte populations and platelets, and count the number of cells from one or more erythrocyte populations in said sample.
| Methods and compositions for labeling nucleic acids|
The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. Certain methods are provided that include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label.
| Novel polymavirus associated with diarrhea in children|
Provided is a new polyomavirus, provisionally named mx polyomavirus, (mxpyv). Further provided are cdna nucleic acid sequences, recombinant proteins, expression vectors and host cells, recombinant anti-mxpyv antibodies, vaccines, compositions, methods of detecting mxpyv, methods for assaying for anti-mxpyv compounds, and methods for treating or preventing a mxpyv infection..
| Apparatuses for and methods of processing cells and related structures|
Apparatus for processing life-based organic particles, including particles selected from the list comprising cells, cellular spheroids, tissues, eukaryotes, micro-organisms, organs or embryos, comprises a hollow volume (10) that (a) is internally divided into at least first (14), second (16) and third (17) sub-volumes by at least two phaseguides (12, 13) formed inside the volume and (b) includes parts that are relatively upstream and relatively downstream when judged with reference to the movement of a meniscus or a bulk liquid in the volume (10). The apparatus includes at least first, second and third fluid conduits (19, 21, 22) connected to permit fluid communication between the upstream exterior of the volume (10) and a respective said sub-volume (14, 16, 17); and at least one further conduit (24) connected to permit fluid communication between the downstream exterior of the volume (10) and a said sub-volume.
| Process for producing rechargeable electrochemical metal-oxygen cells|
The invention relates to a process for producing a rechargeable electrochemical metal-oxygen cell, comprising at least one positive electrode, at least one negative metal-comprising electrode and at least one separator having two sides for separating the positive and negative electrodes, wherein, in one of the process steps, at least one side of the separator is coated with at least one material for forming one of the two electrodes (hereinafter referred to as electrode material) or at least one side of at least one of the two electrodes is coated with at least one material for forming the separator (hereinafter referred to as separator material) to form a separator-electrode assembly.. .
| Gas diffusion electrodes for metal-oxygen cells and their production|
The present invention further relates to processes for producing such gas diffusion electrodes and rechargeable electrochemical metal-oxygen cells comprising such gas diffusion electrodes.. .
| Mixed-metal platinum catalysts with improved carbon monoxide tolerance|
Disclosed are catalysts, especially catalytic anodes, useful for catalyzing reactions in fuel cells and in other environments. The catalysts have a substrate base made of iridium and/or ruthenium.
| Temperature dependent ionic gate|
An electrochemical device having a liquid electrolyte which includes a protic solvent, an anode electrode disposed in contact with the liquid electrolyte, and a cathode electrode disposed in contact with the liquid electrolyte. A membrane which interrupts the transport of ions between the electrodes at a predetermined temperature is disposed in the liquid electrolyte between the anode electrode and the cathode electrode.
| Stack for simulating cell voltage reversal behavior in fuel cell|
Disclosed is a stack for simulating a cell voltage reversal behavior in a fuel cell. The stack is configured to have a structure in which a separator of a portion of a plurality of cells in the stack have an inlet of a hydrogen flow field partially blocked to induce hydrogen starvation only in the portion of the plurality of cells..
| Module for a fuel cell stack|
A fuel cell stack (10) having a plurality of modules (12) and each module (12) having an elongate hollow member (14). Each hollow member (14) has a first flat surface (16) and a second flat surface (18) arranged parallel to the first flat surface (16).
| Cooling system for a fuel cell|
The invention relates to a cooling system for a fuel cell, comprising a main heat-transfer-fluid circuit including a circulation pump (6) and a heat exchanger (8) with the exterior, which feed an upstream pipe (12) supplying the fluid to the cells (4) of the fuel cell, said fluid leaving the cells via a downstream pipe (14) in order to return to the main pump. The invention is characterised in that the main circuit comprises a three-port controlled valve (10, 16) on each upstream (12) and downstream (14) pipe, the third available port (10c) of the upstream pipe (12) being connected to the inlet of the pump (6) and the third available port (16c) of the downstream pipe (14) being connected to the outlet of the pump in order to establish a secondary fluid circuit..
| Apparatus for electronic devices with vibrators and fuel cells|
The disclosure is directed to efficiently harnessing the mechanical energy of actuators used for producing vibration alerts in portable electronic devices to control the flow of fuel and mix the fuel in devices with fuel cells. Example embodiments control the flow of fuel into a reaction area and/or mix fuel in a fuel storage area of a fuel cell assembly.
| Gas diffusion electrodes for rechargeable electrochemical cells|
The present invention further relates to a process for producing such gas diffusion electrodes and also rechargeable electrochemical cells comprising such gas diffusion electrodes.. .
| Cell wiring module|
A cell wiring module is configured to include a plurality of connection members connecting adjacent electrode terminals of a plurality of single cells having positive and negative electrode terminals. The cell wiring module includes a first unit housing a housed connection member, and a second unit connected to the first unit by a linking connection member different from the housed connection member.
| Multiple electrode substrate thicknesses in battery cells for portable electronic devices|
The disclosed embodiments provide a battery cell. The battery cell includes an electrode containing an active material and a continuous substrate.
| Battery assembly with adhesive stop mechanism|
A battery assembly provided with an adhesive stop mechanism is disclosed. The battery assembly includes multiple battery cells, a primary retaining frame, a secondary retaining frame, two common electrodes and a bonding layer.
| Battery pack for a vehicle|
A battery pack for a vehicle includes a plurality of electrically connected battery cells and at least one current interruption device. The at least one current interruption device comprises a movable pressure sensitive element which is engaged by a pressure rise inside the battery pack and whose engagement leads to an electrical disconnection of one or more battery cells..
| Large area, low-defect gallium-containing nitride crystals, method of making, and method of use|
An ultralow defect gallium-containing nitride crystal and methods of making ultralow defect gallium-containing nitride crystals are disclosed. The crystals are useful as substrates for light emitting diodes, laser diodes, transistors, photodetectors, solar cells, and photoelectrochemical water splitting for hydrogen generators..
| Forming cellular material by melt-stretching melt-stretchable material|
A material with a cellular structure is formed from melt-stretched granules. Granules compressed between stretching surfaces are melted to form viscous molten layers attaching ends of the granules to the surfaces.
| Intracellular calcium modulation for cancer treatment|
Tumor cells exhibit consistent abnormalities in calcium regulation. The present disclosure teaches methods by which such differences are exploited to induce apoptosis selectively in tumor/cancer cells while sparing normal cells.
| Neural stem cells derived from induced pluripotent stem cells|
The present invention provides novel populations of neural stem cells derived from induced pluripotent stem cells, and methods for making and using the same.. .
| Novel preparation technique for higher-order structure that exhibits anticellular effect|
Disclosed is a novel means by which cyanoacrylate polymer particles still more useful as an antibacterial agent, an anticancer agent, etc., than conventional particles. The method for production of cyanoacrylate polymer particles according to the present invention comprises anionically polymerizing a cyanoacrylate monomer(s) in the presence of at least one selected from the group consisting of amino acids, amino acid derivatives, and oligomers and polymers thereof, and substantially in the absence of a saccharide and substantially in the absence of a polysorbate.
| Therapies for cancer using rlip76|
The present invention is a composition identified as a region of rala binding protein 1, wherein the region neighbors a membrane-associated portion of the rala binding protein 1, reduces transport activity and membrane association of the rala binding protein 1 and kills cells undergoing uncontrolled cell growth in a subject that has cells undergoing uncontrolled cell growth. The region is used to generate medicines that kill malignant cells and tumorigenic cells.
| Compositions and methods for delivering nucleic acid to a cell|
Provided are novel compositions useful for delivering nucleic acids to cells. Also provided are methods for making and using such compositions..
| Zscan4 as a marker for pancreatic stem cells and progenitor cells and use thereof|
Zscan4, a gene expressed in es cells and 2-cell stage embryos, has been previously shown to regulate telomere elongation and genome stability in mouse es cells. It is disclosed herein that in the adult human pancreas, a small number of zscan4-positive cells are present among cells located in the islets of langerhans, acini, and ducts.
| Tumor lysate loaded particles|
Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the major histocompatibility complex class i pathway and can be used as a vaccine to treat cancer, including ocular melanoma..
| Immunostimulant for animals, feed containing the same, and method for producing the same|
By administering sterilized bacterial cells obtained by heat treating cells of a coryneform bacterium or an enterobacterium under a condition of ph 2 to 5 at 90 to 120° c. For 3 minutes to 4 hours, or a feed containing such sterilized bacterial cells to a mammal, fowl, fish, or crustacean, immunity of these animals is enhanced..
| T-cell death-inducing epitopes|
Cell death-inducing epitopes and polypeptides containing same. Also disclosed are compounds for inducing death of activated t-cells, a method of producing antibodies to the epitopes, a method of identifying compounds that bind to the epitopes, a method of inducing death of activated t-cells, and pharmaceutical compositions containing the compounds..
| Carrier peptides for cell delivery|
The invention relates to the technological sector of the transport and delivery of molecules into cells, either at cytoplasm or at nucleus or inter-cells (cell to cell transport), using peptides binding proteins from the cell microtubule motor complex, preferably dynein-binding peptides, as carrier/delivery peptides; or functionalized structures, as nanoparticles, linked to said carrier/delivery peptides. This delivery can be useful in many technical fields comprising, among some others: diagnosis, therapy and pharmacology..
| Tumor lysate loaded particles|
Dendritic cells containing tumor lysate loaded particles are prepared. The dendritic cells present tumor antigens to elicit the major histocompatibility complex class i pathway and can be used as a vaccine to treat cancer, including ocular melanoma..
| Methods of treating acute myeloid leukemia by blocking cd47|
Methods are provided to manipulate phagocytosis of cancer cells, including e.g. Leukemias, solid tumors including carcinomas, etc..
| Anti-kit antibodies and uses thereof|
Provided herein, in one aspect, are antibodies that immunospecifically bind to a human kit antigen comprising the fourth and/or fifth extracellular ig-like domains (that is, d4 and/or d5 domains), polynucleotides comprising nucleotide sequences encoding such antibodies, and expression vectors and host cells for producing such antibodies. The antibodies can inhibit kit activity, such as ligand-induced receptor phosphorylation.
| Human igm antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system|
Antibodies, particularly human antibodies, are disclosed having activity in treatment of demyelinating diseases and diseases of the central nervous system. Neuromodulatory agents are provided comprising a material selected from the group consisting of an antibody capable of binding structures or cells in the central nervous system, a peptide analog, and active fragments, monomers and combinations thereof having one or more of the following characteristics: capable of inducing remyelination; binding to neural tissue; promoting ca++ signaling with oligodendrocytes; and promoting cellular proliferation of glial cells.
| Antibody with specificity for gm-csf (ii)|
The present invention relates to antibodies with specificity for granulocyte-macrophage colony stimulating factor (gm-csf). More particularly, the invention relates to humanized monoclonal antibodies that bind specifically to human gm-csf with high affinity.
| Combination therapy|
The invention provides for the treatment of diseases or disorders characterized by cells expressing the cd40 membrane glycoprotein. The invention provides methods for the treatment of various diseases or disorders characterized by cells expressing cd40 with a combination of an agent causes the depletion of cells expressing cd40 and a second agent which causes the depletion of cells expressing the cd20 membrane antigen.
| Methods for treating melanoma|
Methods of inhibiting melanoma tumor growth, methods of treating melanoma and metastatic melanoma, and methods of reducing the frequency of tumor initiating cells (or cancer stem cells) in melanoma tumors are described. The methods described comprise administering a dll4 antagonist (e.g., an antibody that specifically binds the extracellular domain of human dll4) to a subject.
| Induction of tumor hypoxia for cancer therapy|
Methods and compositions for enhancing the ability of hypoxia-activated bioreductive agents to kill tumor cells within solid tumors are provided. Local regions of hypoxia are created within a tumor, or within a region containing a tumor, resulting in enhanced activation of hypoxia-activated bioreductive agents (e.g.
| Humanized anti-factor d antibodies and uses thereof|
The invention relates to anti-factor d antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their production and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease..
| Dioxino- and oxazin-[2,3-d]pyrimidine pi3k inhibitor compounds and methods of use|
Dioxino- and oxazin-[2,3-d]pyrimidine pi3k inhibitor compounds of formula i with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with pi3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic pi3k inhibitor compounds of formula i for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions..
| Staphylococcus haemolyticus prophage phish2 endolysin is lytic for staphylococcus aureus|
Methicillin-resistant (mrsa) and multi-drug resistant strains of staphylococcus aureus are becoming increasingly prevalent in both human and veterinary clinics. S.
| Delivery of compounds with rehydrated blood cells|
Fixed-dried blood cells carrying an active agent are described, along with methods of making the same, methods of using the same, and compositions containing the same. The blood cells are preferably blood platelets..
| Methods of expanding and assessing b cells and using expanded b cells to treat disease|
Provided herein are methods of expanding b cells, and in particularly b10 cells capable of producing il-10, ex vivo. The methods include incubation of harvested b cells in the presence of il-21.
| Methods for producing and using rejuvenated red blood cells|
Methods for treating blood. The methods comprise obtaining whole blood from a donor, mixing the whole blood with a red blood cell enhancement composition, and incubating the mixture of whole blood and red blood cell enhancement composition.
| Compositions and methods for mesenchymal/stromal stem cell rejuvenation and tissue repair by enhanced co-expression of telomerase and myocardin|
A major risk factor for ischemic heart disease is advanced age. In adult bone marrow and other tissues, the number and function of stem cells decline with aging.
| Affinity maturated t cell receptors and use thereof|
The present invention relates to methods and systems for increasing the affinity of a t cell receptor (tcr) to its ligand by subjecting the tcr gene to somatic hypermutation. The present invention further relates to use of affinity maturated tcrs to create t cells reactive against a selected antigen..
| Genetically modified msc and therapeutic methods|
This disclosure relates to vectors, isolated cells, compositions, and methods for the treatment of critical limb ischemia and associated disorders. One aspect of the disclosure relates to a vector comprising a nucleic acid encoding a 165a isoform vegf protein and a promoter that regulates expression of the nucleic acid encoding the vegf..
| Use of substance p for mobilization of mesenchymal stem cells or proliferation of mesenchymal stem cells and for wound healing or facilitating wound healing|
The present invention relates to a use of substance-p for the manufacture of a medicament for mobilization or proliferation of mesenchymal stem cells (mscs) from the bone marrow, or facilitating said mobilization or proliferation, and use of substance-p for the manufacture of a medicament for wound-healing or facilitating wound-healing.. .
| Tendon stem cells|
The invention relates to tendon stem cells useful for treating a variety of diseases and condition, including tendon repair and attachment of tendon to bone. The invention is also directed to treatment and/or inhibition of bone formation by use of biglycan and/or fibromodulin..
| Proteins for use in human and animal staphylococcus infections|
The present invention relates to a polypeptide termed ply_pitti26 comprising the sequence as depicted in seq id no:1 as well as variants of this polypeptide. Furthermore, the present invention relates to nucleic acids and vectors encoding for said polypeptide and variants thereof as well as host cells comprising these nucleic acids and/or vectors.
| Method to augment immune system in response to disease or injury|
In one example, the present invention comprises a deliberate insult or the recognition that an insult has occurred in a patient, which insult induces an immune recognition event. The t cell repertoire is catalogued from samples of the patient's lymphocytes from before and after the insult in order to detect and sequence the tcr alpha and beta loci of highly expanded t cell clonotypes.
| Cancer therapy by ex vivo activated autologous immune cells|
Disclosed are therapeutic methods for ex-vivo activation of immune cells from a cancer patient for the purpose of inducing tumor regression and/or suppressing metastasis and/or tumor recurrence. In one embodiment mononuclear cells of a patient are isolated from peripheral blood and activated by a combination of innate immune system activators together with means allowing for t cell activation..
| Method of tracking growth and metastasis of specific cells in vivo|
A method of tracking growth and metastasis of specific cells in vivo is disclosed. The method of the disclosure includes culturing the specific cells in a medium containing 0.1 μm to 10 mm nanoparticles as a biomarker for x-rays, such that the specific cells carry the nanoparticles, administering the specific cells carrying the nanoparticles to a subject, irradiating the subject by an x-ray source, and determining the growth and metastasis of the specific cells by x-ray images of the nanoparticles in the subject..
| Modulation of telomere length in telomerase positive cells and cancer therapy|
Induction of telomere shortening, g2 arrest and apoptosis in telomerase positive cancer cells using acyclic nucleoside analogs has been disclosed. In addition, methods for impairment or prevention of tumorigenic telomerase positive cells from having a chance to grow into a tumor and methods for promoting tumor regression (decrease in size of an established tumor) using acyclic nucleoside analogs has been disclosed..
| Vitamin-targeted imaging agents|
The invention relates to compounds and methods for targeting radionuclide-based imaging agents to cells having receptors for a vitamin, or vitamin receptor binding derivative or analog thereof, by using such a vitamin as the targeting ligand for the imaging agent. The vitamin-based compounds can be used to target radionuclides to cells, such as a variety of tumor cell types, for use in diagnostic imaging of the targeted cells..
| Monoclonal antibodies against alpha-actinin-4 antigens, and uses therefor|
Monoclonal antibodies (moabs or mabs) specific for alpha-actinin-4 antigens, hybridoma lines that secrete these alpha-actinin-4 mabs, and the use of such mabs to detect alpha-actinin-4 antigens, particularly those expressed by cancer cells are disclosed. Chimeric and humanized antibodies based upon these anti-alpha-actinin-4 mabs, processes for producing monoclonal, chimeric, and humanized antibodies using recombinant dna technology, and their therapeutic uses, particularly in the treatment of cancer are also disclosed.
| Sulfur degasser apparatus and method|
A novel system and method for degassing h2s and h2sx from liquid sulfur (sulphur) is disclosed. The system includes a degassing vessel with a plurality of cells.
| Treatment of indium gallium alloys and recovery of indium and gallium|
There is provided a hydrometallurgical process of recovering indium and gallium values from mixtures thereof with other metal values for example recycled and scrap solar panel cells which comprises subjecting the mixture to strongly oxidizing acid conditions, preferably via the simultaneous addition of sulfuric acid and hydrogen peroxide to the leach vessel, so as to form indium and gallium salt species of at least the major proportion of the indium and gallium values in the mixture, extracting the indium and gallium values with an organic extractant by adjusting the ph so as to extract individually the indium and gallium values with the organic extractant, stripping indium and gallium values from the extractant using an acid and an alkaline solution respectively and recovering the indium and gallium values.. .
| Active photocatalytic oxidation|
Embodiments of the present disclosure could generally provide an active oxidation and purifying system to maximize the rate of photocatalytic oxidation and ambient air filtration by structurally optimizing the system to maximize potential ultraviolet (uv) light exposure to the surface and apertures of the active power cells. In one example, the active power cells could include a plurality of apertures disposed in a transverse manner from the first surface to the second surface of the active power cell.
| Methods for inactivating fluid cultures through heating|
A method for inactivating a fluid culture includes inserting a collapsible bag within a chamber of a tank assembly. A fluid is dispensed into a compartment of the collapsible bag, the fluid including a culture containing live cells or microorganisms.