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Cells patents



      
           
This page is updated frequently with new Cells-related patent applications. Subscribe to the Cells RSS feed to automatically get the update: related Cells RSS feeds. RSS updates for this page: Cells RSS RSS


Apparatus and method for processing microscopic single cell biological specimens with a single microtool

Apparatus and method for processing microscopic single cell biological specimens with a single microtool

Date/App# patent app List of recent Cells-related patents
04/23/15
20150113685
 Hsf-like transcription factor, tbf1, is a major molecular switch for growth-to-defense transition in plants patent thumbnailnew patent Hsf-like transcription factor, tbf1, is a major molecular switch for growth-to-defense transition in plants
The present invention relates to new methods to study and control the expression of plant genes, particularly nucleotide sequences located downstream from regions comprising binding sites for transcription factors, such as the cis-element translocon 1 (tl1) comprising gaagaagaa and similar sequences. The invention relates to isolated nucleotide sequences comprising a regulatory region comprising a promoter operably-linked to one or more upstream open reading frames (uorfs) and one or more downstream open reading frames (dorfs) encoding one or more functional polypeptides, including transcription factors such as tbf1, reporter polypeptides, and polypeptides conferring resistance to drugs, resistance of plants viral, bacterial, or fungal pathogens, and polypeptides involved in the growth of plants.
Duke University
04/23/15
20150113682
 Methods and compositions for root knot nematode control patent thumbnailnew patent Methods and compositions for root knot nematode control
The present invention discloses gene targets, constructs and methods for the genetic control of plant disease caused by nematodes of the genus meloidogyne (root knot nematodes). The present invention relates to achieving a plant protective effect through the identification of target coding sequences and the use of recombinant dna technologies for post-transcriptionally repressing or inhibiting expression of the target coding sequences in the cells of plant-parasitic nematodes.
Monsanto Technology Llc
04/23/15
20150113681
 Composition and  enhancing plant transformation patent thumbnailnew patent Composition and enhancing plant transformation
The invention includes transformation selection medias and methods, including transformation selection media comprising a negative selection agent and containing differing amounts of carbohydrate during incubation of transformed cells during the selection process, including providing an amount of carbohydrate in a transformation selection media and culturing transformed cells therein for a period of time in an incubation step followed by transferring the transformed cells into transformation selection media comprising a negative selection agent and having an amount of carbohydrate that differs from the amount of carbohydrate used in the previous transformation selection media and incubating the cells for another period of time in a second incubation step. Additional incubation steps may be included, wherein the carbohydrate content of the transformation selection media in each step may be different from the carbohydrate content of the transformation selection media used in one or more of the previous incubation steps..
Syngenta Participations Ag
04/23/15
20150113680
 Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules to generate transgenic plants with enhanced agronomic traits patent thumbnailnew patent Isolated novel nucleic acid and protein molecules from corn and methods of using those molecules to generate transgenic plants with enhanced agronomic traits
This disclosure provides purified nucleic acids and polypeptides. Also provided are transgenic plants, seeds, and plant cells containing dna for expression of the proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants, methods of making such plants and methods of making agricultural commodity including seeds and hybrid seeds from such plants..
Monsanto Technology Llc
04/23/15
20150113676
 Transgenic plants with enhanced agronomic traits patent thumbnailnew patent Transgenic plants with enhanced agronomic traits
This invention provides transgenic plant cells with recombinant dna for expression of proteins that are useful for imparting enhanced agronomic trait(s) to transgenic crop plants. This invention also provides transgenic plants and progeny seed comprising the transgenic plant cells where the plants are selected for having an enhanced trait selected from the group of traits consisting of enhanced water use efficiency, enhanced cold tolerance, increased yield, enhanced nitrogen use efficiency, enhanced seed protein and enhanced seed oil.
Monsanto Technology Llc
04/23/15
20150113672
 Composition and methods for producing reconstituted skin patent thumbnailnew patent Composition and methods for producing reconstituted skin
Compositions and methods for producing reconstituted human skin and/or hair follicles in situ are provided. The method for producing the skin is unique in that tissue culture expanded cells including multipotent cells such as neonatal cells as well as cultured epidermal and dermal cells are immediately placed on a substrate such as a membrane and then the membrane with adherent cells is placed on a skin wound.
Aderans Research Institute, Inc.
04/23/15
20150113671
 Nucleic acid for determining actin structures in living cells patent thumbnailnew patent Nucleic acid for determining actin structures in living cells
The present invention relates to nucleic acids encoding peptides capable of binding to actin. The nucleic acids encoding the peptides are useful in methods for detecting actin in vitro or in living cells..
Max-planck-gesellschaft Zur Forderung Der Wissenschaften E.v.
04/23/15
20150113669
 Animal models and therapeutic molecules patent thumbnailnew patent Animal models and therapeutic molecules
The invention discloses methods for the generation of chimaeric human—non-human antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising said antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in said methods.. .
Kymab Limited
04/23/15
20150113492
 Sram layouts patent thumbnailnew patent Sram layouts
Roughly described, the cell layout in an sram array is re-arranged such that the gate electrodes for transistors for which flexibility to use one channel length is desired, are formed along a different track from those for transistors for which flexibility to use a different channel length is desired. Not only does such a re-arrangement permit optimization of device ratios, but also in certain implementations can also reduce, rather than increase, cell area.
Synopsys, Inc.
04/23/15
20150113379
 Representation of unstructured grids patent thumbnailnew patent Representation of unstructured grids
A method can include receiving an unstructured grid of a multi-dimensional region; partitioning at least a portion of the unstructured grid into subdomains based at least in part on a cell number criterion; generating a hierarchical representation of the at least a portion of the unstructured grid that includes the subdomains and the cells; indexing cells in the subdomains based at least in part on the cell number criterion to define a data structure; and assigning respective property values to respective indexed cells for at least a portion of the data structure.. .
Schlumberger Technology Corporation
04/23/15
20150113378
new patent

Techniques to present a dynamic formula bar in a spreadsheet


Various embodiments are generally directed to techniques and apparatuses to present a dynamic formula bar in a spreadsheet application. Some embodiments are particularly directed to presenting a dynamic formula bar in a spreadsheet application that may improve usability in particular with large display sizes and/or touchscreen interfaces.
Microsoft Corporation
04/23/15
20150113377
new patent

Micro browser spreadsheet viewer


Various technologies and techniques are disclosed for displaying and managing spreadsheets on mobile devices. An optimized search can be performed.
Microsoft Technology Licensing, Llc.
04/23/15
20150113342
new patent

Nonvolatile memory device including dummy wordline, memory system, and operating memory system


A method of operating a memory system includes reading data of first memory cells, the first memory cells being connected to a first wordline from among a plurality of wordlines, the plurality of wordlines including one or more dummy wordlines and one or more normal wordlines; determining whether the first wordline is one of the one or more dummy wordlines by determining, based on the read data, a number of the first memory cells having a first threshold voltage state, the one or more dummy wordlines being wordlines the memory cells of which have been programmed with dummy data, the one or more normal wordlines being wordlines that are not dummy wordlines; and performing a repair algorithm for correcting an error in the read data, selectively according to a result of the determination.. .
Samsung Electronics Co., Ltd.
04/23/15
20150113237
new patent

Data storing system and operating method thereof


A method of operating a data storing system includes performing a first copy operation of copying data stored in memory cells of first to nth word lines (n>1, and n is an integer) of a first memory block to first to nth pages of a word line of a second memory block; if a power is turned off, searching for a first erase page, which is recognized to be in an erase state, among the pages of the second memory block when the power comes back on; performing a first map-update on copied pages of the second memory block except for a set number of pages copied right before the first erase page; and performing a second copy operation from the first erase page.. .
Sk Hynix Inc.
04/23/15
20150113213
new patent

Resistive memory device, operating method thereof, and system having the same


A resistive memory device includes a memory cell array including a plurality of resistive memory cells, an address decoder suitable for decoding an address signal and selecting the resistive memory cells, a read/write control circuit suitable for programming data to the memory cell array or reading data from the memory cell array, a voltage generator suitable for generating operation voltages and providing the operation voltages to the address decoder and a controller suitable for controlling the address decoder, the read/write control circuit, and the voltage generator to perform a write operation in response to a write command and a plurality of write data.. .
Sk Hynix Inc.
04/23/15
20150112646
new patent

Methods of designing three dimensional (3d) integrated circuits (ics) (3dics) and related systems and components


Methods of designing three dimensional integrated circuits (3dic) and related systems and components are disclosed. An exemplary embodiment provides an improved cell library for use with existing place and route software in such a manner that the modified software allows building 3dics.
Qualcomm Incorporated
04/23/15
20150112624
new patent

Metrology through use of feed forward feed sideways and measurement cell re-use


Metrology may be implemented during semiconductor device fabrication by a) modeling a first measurement on a first test cell formed in a layer of a partially fabricated device; b) performing a second measurement on a second test cell in the layer; c) feeding information from the second measurement into the modeling of the first measurement; and after a lithography pattern has been formed on the layer including the first and second test cells, d) modeling a third and a fourth measurement on the first and second test cells respectively using information from a) and b) respectively.. .
Kla-tencor Corporation
04/23/15
20150112412
new patent

Methods and devices for selective disruption of fatty tissue by controlled cooling


The present invention relates to methods for use in the selective disruption of lipid-rich cells by controlled cooling. The present invention further relates to a device for use in carrying out the methods for selective disruption of lipid-rich cells by controlled cooling..
The General Hospital Corporation
04/23/15
20150112333
new patent

Method for treating a tubular anatomical structure


An apparatus and method for treatment of a tubular anatomical structure is disclosed. The method includes using an electrical energy to destroy elongated cells on the tubular anatomical structure.
Angiodynamics, Inc.
04/23/15
20150112288
new patent

Targeted delivery of magnetically tagged active agents in combination with negative pressure wound therapy


Methods and systems for treating a wound using targeted delivery of magnetically-tagged active agents in combination with negative pressure wound therapy are presented. In particular, a magnetically-active wound insert may be used to attract magnetically-tagged stem cells to a wound site to treat the wound..
Kci Licensing, Inc.
04/23/15
20150112247
new patent

System for gas treatment of a cell implant


System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine.
Giner, Inc.
04/23/15
20150112205
new patent

Optical speculum


A system for direct imaging and diagnosing of abnormal cells in a target tissue includes a disposable optical speculum and an image acquisition system having the speculum assembled on and mechanically secured thereto. The image acquisition system is arranged to capture at least one of a single image or multiple images or video of cells within the target tissue using at least one of bright field or dark field ring illumination divided into independently operated segments to obtain a plurality of data sets.
Illumigyn Ltd.
04/23/15
20150112203
new patent

Method for characterizing a cornea and obtaining an ophthalmic lens


A system and method for determining the shape of a cornea of an eye illuminates at least one of the interior surface, the posterior surface, and the interior region of the eye with infrared light of a wavelength that can generate fluorescent light from the portion of the cornea illuminated. The generated fluorescent light is then detected.
Perfect Ip, Llc
04/23/15
20150112125
new patent

Methods for sorting sperm and producing sexed embryos


A method of sorting sperm cells and a method of producing at least one sexed embryo. The method of sorting sperm cells includes the steps of establishing a sheath fluid environment including a citrate for stained sperm cells, establishing a stream including stained sperm cells in said sheath fluid environment, sensing a property of the stained sperm cells, and discriminating between stained sperm cells for a desired sex characteristic.
Xy, Llc
04/23/15
20150112052
new patent

Sequence-determined dna fragments with regulatory functions


The present invention provides dna molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The dna molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an utr or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related dna fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait..
Ceres, Inc.
04/23/15
20150112042
new patent

Antigen delivery vectors and constructs


The present invention relates to fluorocarbon vectors for the delivery of antigens to immunoresponsive target cells. It further relates to fluorocarbon vector-antigen constructs and the use of such vectors associated with antigens as vaccines and immunotherapeutics in animals..
Immune Targeting Systems Ltd.
04/23/15
20150111955
new patent

Aav vector compositions and methods for gene transfer to cells, organs and tissues


The invention relates to adeno-associated virus (aav) serotype aav-rh74 and related aav vectors, and aav-rh74 and related aav vector mediated gene transfer methods and uses. In particular, aav-rh74 targets polynucleotides to cells, tissues or organs for expression (transcription) of genes encoding therapeutic proteins and peptides, and polynucleotides that function as or are transcribed into inhibitory nucleic acid sequences..
The Children's Hospital Of Philadelphia
04/23/15
20150111953
new patent

Modulator compounds of drug resistance in epithelial tumor cells


The described invention provides a method of treating a patient with an epithelial cancer comprising administering a composition comprising a therapeutic amount of an inhibitor of a btk protein and one or more chemotherapeutic agent(s) selected from the group consisting of an antimetabolite, a platinum coordination compound, an alkylating agent and a combination thereof, wherein the composition is effective to reduce one or more of tumor cell growth, tumor cell clonogenicity, tumor cell proliferation, tumor cell viability and tumor volume and the therapeutic amount of the inhibitor of a btk protein and the one or more chemotherapeutic agent(s) exerts a synergistic effect. The described invention also provides methods of treating a chemotherapy drug-resistant cancer and sensitizing a cancer patient to chemotherapy..
04/23/15
20150111950
new patent

Inhibition of dna2 in fanconi anemia


Inhibition of dna2 in fanconi anemia (fa) cells remedies the over-resection of dna, thereby stabilizing the fa cells. Inhibition of dna2 in fa cells allows for safe treatment of cancers in fa patients, a decrease in the lethality of fa cells, a decrease in bone marrow failure of fa patients, and a means for decreasing the incidence of cancer for fa patients..
California Institute Of Technology
04/23/15
20150111948
new patent

Rna-interference-inducing nucleic acid molecule able to penetrate into cells, and use therefor


The present invention relates to a novel, rnai-inducing nucleic acid molecule having cell penetrating ability and the use thereof, and more particularly, to a novel, rnai-inducing double-stranded nucleic acid molecule, which has a replacement of the phosphate backbone of at least one nucleotide with phosphorothioate or phosphorodithioate, and has a lipophilic compound conjugated thereto, and thus has high target gene-silencing efficiency while having the ability to penetrate cells without needing a separate intracellular delivery vehicle, and to a method of silencing a target gene using the nucleic acid molecule. The nucleic acid structure according to the present invention has both cholesterol modification and phosphorothioate modification introduced therein, and thus has high gene silencing efficiency while having the ability to penetrate cells without needing a separate intracellular delivery vehicle.
Bmt, Inc.
04/23/15
20150111911
new patent

Treating bax(delta)2-positive cancer with chemotherapies targeting caspase 8


Discovery of a new bax isoform, baxΔ2, in cancer cell lines and primary tumors is described. The baxΔ2 isoform resulted from combination of bax microsatellite mutation and alternative splicing bax exon 2.
Mumetel, Llc
04/23/15
20150111903
new patent

Pharmaceutical formulations comprising neurotrophin mimetics


Methods and compounds for treating neurodegenerative and other disorders. Included is the administering to a subject in need thereof an effective amount of a compound having binding specificity for a p75ntr receptor molecule.
U.s. Government Represented By The Department Of Veterans Affairs
04/23/15
20150111902
new patent

Methods for altering mrna splicing and treating familial dysautonomia by administering kinetin, benzyladenine, and tocotrienols


This invention relates to methods for altering the splicing of mrna in cells. In particular, this invention also relates to methods for increasing the ratio of wild type to misspliced forms of mrna and corresponding encoded proteins in cells possessing a mutant gene encoding either the i) misspliced mrna corresponding to the mutant protein or ii) a component in the splicing machinery responsible for processing the misspliced mrna.
The General Hospital Corporation
04/23/15
20150111896
new patent

Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors


Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin-dependent kinase (cdk) 4/6 inhibitors to induce transient quiescence in cdk4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells.
The University Of North Carolina At Chapel Hill
04/23/15
20150111842
new patent

Attractant for bone marrow stem cells and attracting bone marrow stem cells


Provided are an attractant for bone marrow stem cells containing at least one of cinnamtannin b1 and pentagalloylglucose, and a method for attracting bone marrow stem cells in which bone marrow stem cells are attracted by the attractant.. .
Osaka University
04/23/15
20150111822
new patent

Wnt7a compositions and using the same


There are provided compositions and methods for modulating stem cell division, in particular, division symmetry. It has been demonstrated that wnt7a polypeptide fragments promoting symmetrical expansion of stem cells.
Ottawa Hospital Research Institute
04/23/15
20150111821
new patent

Mutated fibroblast growth factor (fgf) 1 and methods of use


The present disclosure provides fgf1 mutant proteins, such as those having an n-terminal deletion, point mutation(s), or combinations thereof, which can reduce blood glucose in a mammal. Such mutant fgf1 proteins can be part of a chimeric protein that includes a β-klotho-binding protein, an fgfr1c-binding protein, a β-klotho-binding protein and a fgfr1c-binding protein, a c-terminal region from fgf19 or fgf21.
Salk Institute For Biological Studies
04/23/15
20150111784
new patent

Detecting cells secreting a protein of interest


In some cases, the described systems and methods include obtaining a cell sample containing multiple antibody-producing cells. In such cases, the cells can be tagged with a cross-linking reagent having a first portion configured to bind to a marker on the antibody-producing cells and a second portion configured to bind to an antigen of interest.
Berkeley Lights, Inc.
04/23/15
20150111771
new patent

Method for identifying agents capable of inducing respiratory sensitization and array and analytical kits for use in the method


The present invention relates to an in vitro method for identifying agents capable of inducing respiratory sensitization in a mammal and arrays and diagnostic kits for use in such methods. In particular, the methods include measurement of the expression of the biomarkers listed in table 1a, table 1b and/or table 1c in mutz-3 cells exposed to a test agent..
Senzagen Ab
04/23/15
20150111768
new patent

Methods for generation of pluripotent and multipotent cells


This disclosure relates to methods of producing induced pluripotent (ips), multipotent, and/or lineage-committed stem cells from differentiated cells, maintaining ips, multipotent, and/or lineage-committed cells in culture, and re-differentiating the ips and multipotent stem cells into any desired lineage-committed cell type.. .
The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services
04/23/15
20150111767
new patent

Method and kit for the detection of hepatitis-specific antibodies


The present invention relates to an improved method for detecting antibodies to a hepatitis virus in a tissue sample from individuals, which can reliably detect antibodies in recently infected individuals and which provides much lower false positive results in individuals that have cleared their hepatitis infections. More particularly, the present invention relates to an improved method and kit which utilizes an activator of (i) hepatitis virus-primed lymphocytes, (ii) memory cells specific for said hepatitis virus, (iii) hepatitis virus-specific antibody production, or (iv) a combination thereof in a tissue sample to stimulate the production of antibodies from newly primed b cells, if present..
Smart Biotech Ltd.
04/23/15
20150111766
new patent

Fluorescent neutralization and adherence inhibition assays


The present invention comprises rugged, inexpensive, reliable, and sensitive laboratory assays of antibody-based viral neutralization activity and antibody-based viral adherence inhibition activity. The assays use inactivated, fluorescently-labeled virus, allowing the tests to be performed without extensive safety precautions.
Sanofi Pasteur Vaxdesign Corporation
04/23/15
20150111728
new patent

Method of fabricating honeycomb catalyst of nano metal oxides for natural gas reforming


A honeycomb catalyst is fabricated. The catalyst is made of nano metal oxides.
Institute Of Nuclear Energy Research, Atomic Energy Council, Executive Yuan, R.o.c.
04/23/15
20150111593
new patent

Method and system for improving efficiency in a cellular communications network


A method and system are described for improving operating efficiency and qos in a cellular communications network. According to an exemplary embodiment, the method includes predicting background interference levels due at least partly to signals generated in neighboring cells, and transmitting operating parameters to user equipment that include power, frequency, and/or spectral efficiency parameters.
Collision Communications, Inc.
04/23/15
20150111588
new patent

Receiving cell broadcast (cb) messages


A method for receiving cell broadcast messages is described. The method includes communicating with a first cell.
Qualcomm Incorporated
04/23/15
20150111584
new patent

Overlapping cells for wireless coverage


A system is provided for overlapping cells for wireless coverage in a cellular communication system. The system includes a beam-weight generator and beamformer coupled to the beam-weight generator.
The Boeing Company
04/23/15
20150111579
new patent

Mobility management based on cell size


A mobility management method of a wireless communication device is disclosed. The method comprises receiving a first signal related to a first cell, determining a size of the first cell based on the first signal, receiving a second signal related to a second cell, and determining a size of the second cell based on the second signal.
Telefonaktiebolaget L M Ericsson (publ)
04/23/15
20150111503
new patent

Method and cell controlling node for supporting network management


A method and cell controlling node providing radio communication in a first cell of a communication network, for supporting management of the communication network based on performance related reports sent to a management system. Signal measurement reports are obtained from user equipments being served by the first cell controlling node, on measurements on signals from cell controlling nodes in neighbouring cells.
Telefonaktiebolaget L M Ericsson (publ)
04/23/15
20150111337
new patent

Phenanthro[9,10-b]furan polymers and small molecules for electronic applications


Phenanthro[9,10-b]furan polymers and small molecules for electronic applications. The present invention relates to polymers comprising a repeating unit of the formula (i), (ii), (viii), (ix) and compounds of formula (viii), or (ix), wherein y, y15, y16 and y17 are independently of each other a group of formula (i), or (ii), and their use as organic semiconductor in organic electronic devices, especially in organic photovoltaics and photodiodes, or in a device containing a diode and/or an organic field effect transistor.
Basf Se
04/23/15
20150111335
new patent

Module-level processing of silicon photovoltaic cells


A method for module-level processing of photovoltaic cells is provided. The method includes: bonding at least one crystalline silicon photovoltaic substrate to a carrier by means of an adhesive layer, thereby leaving part of the adhesive layer uncovered; after bonding, exposing the uncovered part of the adhesive layer and the at least one crystalline silicon photovoltaic substrate to a plasma; and removing a surface portion of the at least one crystalline photovoltaic substrate.
Imec Vzw
04/23/15
20150111333
new patent

Advanced hydrogenation of silicon solar cells


Iii) heating the device, or a local region of the device to at least 40° c. While simultaneously illuminating at least some and/or advantageously all of the device with at least one light source whereby the cumulative power of all the incident photons with sufficient energy to generate electron hole pairs within the silicon (in other words photons with energy levels above the bandgap of silicon of 1.12 ev) is at least 20 mw/cm2.
04/23/15
20150111320
new patent

Integrated circuit combination of a target integrated circuit and a plurality of photovoltaic cells connected thereto using the top conductive layer


A device having a plurality of thin film photovoltaic cells (pv) formed over a passivation layer. The device comprises a plurality of thin film photovoltaic (pv) cells formed over the passivation layer, each pv cell includes at least a lower conducting layer (lcl) and an upper conducting layer (ucl); and a conducting path connecting at least a ucl of a first pv cell to at least a lcl of a second pv cell, wherein at least a first array of pv cells comprised of at least a first portion of the plurality of pv cells is connected by the respective ucl and lcl of each pv cell to provide a first voltage output.
Sol Chip, Ltd.
04/23/15
20150111297
new patent

Apparatus and processing microscopic single cell biological specimens with a single microtool


An oocyte and embryo-positioning apparatus enables a plurality of oocytes, embryos or other cell specimens to be held and positioned for injection therein of fluid molecular reagents such as dna, rna, protein, cells, spermatozoa and cells; and removal of cells, fragments of cells, cytoplasm, nuclei and cellular organelles. The oocytes and embryos are kept separate from each other in open marked or unmarked well-compartments that are located in the culture container.
04/23/15
20150111296
new patent

Transcription factor mediated programming towards megakaryocytes


This invention relates to the forward programming of pluripotent stem cells (pscs) into megakaryocyte (mk) progenitor cells using the transcription factors gata1, fli1 and tal1. Methods of producing megakaryocyte (mk) progenitor cells and subsequently differentiating them into mature megakaryocytes are provided..
Cambridge Enterprise Limited
04/23/15
20150111295
new patent

Elutriation chamber for an elutriator system


The invention relates to an elutriation chamber for an elutriator system for washing and/or isolating cells, in particular thrombocytes, which elutriation chamber comprises a feed line (1) for an aqueous medium containing the cells to be washed and/or to be isolated in suspended form, and a discharge line (2) for the washed and/or isolated cells, wherein the chamber (5) is rotationally symmetrical to the axis (a), characterized in that the ratio of the area of the section through the lumen of the chamber (5) perpendicular to the axis (a) at the widest point (5a-5b) to the area of the section (1a) through the feed line (1) is in the range of 1,000 to 250,000.. .
Bio-products & Bio-engineering Ag
04/23/15
20150111291
new patent

Cell division tracking apparatus and the same, and non-transitory computer readable storage medium to store a cell division tracking program


A cell division tracking apparatus includes a control unit, a search range setting unit, a daughter cell judgment unit. The control unit tracks division processes of the cells based on a cell image group composed of the cell images.
Olympus Corporation
04/23/15
20150111279
new patent

Class i anti-cea antibodies and uses thereof


The present invention provides compositions and methods of use of humanized, chimeric or human class i anti-cea antibodies or fragments thereof, preferably comprising the light chain variable region cdr sequences sassrvsyih (seq id no:1); gtstlas (seq id no:2); and qqwsynppt (seq id no:3); and the heavy chain variable region cdr sequences dyyms (seq id no:4); fiankanghttdyspsvkg (seq id no:5); and dmgirwnfdv (seq id no:6). The class i anti-cea antibodies or fragments are useful for treating diseases, such as cancer, wherein the diseased cells express ceacam5 and/or ceacam6 antigens.
Immunomedics, Inc.
04/23/15
20150111277
new patent

Cell washing device using a wave


A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution.
Biomet Biologics, Llc
04/23/15
20150111276
new patent

Blood cell sorting methods and systems


The invention relates to methods of isolating white blood cells (wbcs) from a sample, e.g., whole blood, using magnetic particles that specifically bind to wbcs and a series of specific steps and conditions. The methods can include one or more of decreasing the viscosity of the sample prior to wbc isolation, agitating the sample at specified frequencies, and/or using a sample container arranged such that all of the sample is placed in close proximity (e.g., within 5, 2, 1, or 0.5 mm) to the source of the magnetic field.
The General Hospital Corporation
04/23/15
20150111263
new patent

Methods and products for generating oils


Compositions and methods for enhancing secretion of oils from oil producing cells are described herein. In particular, secretion of oils is enhanced by treating the cells with herbicides.
Scott & White Healthcare
04/23/15
20150111252
new patent

Method and antibody production and purification


The subject invention pertains to methods and apparatus for the production and purification of cell products, such as immunoglobulins. One aspect of the invention is an integrated cell culture and purification apparatus for the growth and maintenance of cells and the harvest and purification of cell products, such as immunoglobulins.
Biovest International, Inc.
04/23/15
20150111250
new patent

Methods and compositions for modulating tumor cell activity


Antibodies which target clusterin, a protein involved in the epithelial-to-mesenchymal transition of carcinoma cells, are identified and characterized. The antibodies may be used to modulate tumour cell activity through binding to clusterin..
National Research Council Of Canada
04/23/15
20150111249
new patent

Recombinant bacterial host cell for protein expression


The present disclosure relates to a recombinant gram-negative bacterial cell comprising: a.) a mutant spr gene encoding a spr protein having a mutation at one or more amino acids selected from d133, h145, h157, n31, r62, i70, q73, c94, s95, v98, q99, r100, l108, y115, v135, l136, g140, r144 and g147 and b.) a gene capable of expressing or overexpressing one or more proteins capable of facilitating protein folding, such as fkpa, skp, sura, ppia and ppid, wherein the cell has reduced tsp protein activity compared to a wild-type cell, methods employing the cells, use of the cells in the expression of proteins in particular antibodies, such as anti fc rn antibodies and proteins made by the methods described herein.. .
Ucb Pharma S.a.
04/23/15
20150111241
new patent

Inlet and outlet geometries for a vertical three-stream microfluidic device


An example includes an apparatus for separating cells from a fluid sample, including a plenum, defining: a centrally located top inlet, and respective side outlets disposed below the inlet and to the side of the inlet; and a bottom outlet disposed below the top inlet, to the side of the two or more outlets, wherein the plenum is configured to receive a fluid and cells suspension through the inlet, and direct it to the bottom outlet, against respective side-walls extending between the bottom outlet and the two or more side outlets, and wherein the distance between each of the two or more side outlets and the bottom outlet is selected to encourage cells to exit through the bottom outlet under a force. Lateral/vertical distance between the inlet and side outlets can provide lateral fluid travel, thereby allowing time for gravity to bias cells toward an outlet..
Regents Of The University Of Minnesota
04/23/15
20150111238
new patent

Method for detecting disease biomarkers


There is presently provided a method of detecting a bio-marker for a genetic disease in an individual. The method involves comprising identifying the presence of a proteolytic peptide in a polypeptide fraction obtained from a cellular extract of cells from the individual.
Mahidol University
04/23/15
20150111226
new patent

Method for peptide histochemical diagnosis


The present invention provides a method of peptide histochemical diagnosis to detect the peptide binding protein in the cancer tissue. This peptide binding specifically to tumor cells is linked to the dextran coated iron oxide nanoparticle.
National Taiwan University
04/23/15
20150111225
new patent

Method for in vitro differentiation of blood circulating cells into neuronal-like cells and applications thereof


The present invention relates to a method for in vitro differentiation of a population of blood circulating cells, such as monocytes and preferably pluripotent macrophages derived therefrom, into cells displaying functional and phenotypic neuronal characteristics. The invention further encompasses neuronal-like cells obtainable according to the present method, compositions comprising said cells, and applications thereof..
Assistance Publique - Hopitaux De Paris
04/23/15
20150111218
new patent

Cell differentiation assay method, cell isolation method, producing induced pluripotent stem cells, and producing differentiated cells


Provided are a method for accurately evaluating the differentiation status of stem cells by selectively staining only stem cells in an undifferentiated state, and a method for positively isolating only stem cells in an undifferentiated state. Specifically provided is a method for determining differentiation of a cell comprising a step of contacting a test cell with a probe comprising protein (a) or (b) below and a step of detecting the presence of binding of the probe to the test cell.
Wako Pure Chemical Industries, Ltd.
04/23/15
20150111217
new patent

Marker quantitation in single cells in tissue sections


Improved assays incorporating single-cell based image analyses that enable quantitation of expression of individual cellular proteins and heterogeneity in terms of individual cellular protein molecule numbers per cell at the single cell level and mapped across sections of clinical tissue samples are disclosed.. .
Merrimack Pharmaceuticals, Inc.
04/23/15
20150111209
new patent

Gene amplification of coactivator coaa and uses thereof


It has been discovered that amplifications in the gene coactivator activator (coaa) blocks stem cell differentiation and induces cancer stem cells. One embodiment provides compositions and methods for treating or alleviating one or more symptoms associated with cancer due to gene amplifications in coaa.
04/23/15
20150111195
new patent

Cell washing device using a wave


A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution.
Biomet Biologics, Llc
04/23/15
20150111193
new patent

Methods and solutions for tissue preservation


Described herein are compositions and methods particularly useful in the medical arts. The compositions and methods may be used in connection with the preservation of a portion of a mammal, for example, tissues, organs, appendages, limbs, extremities, stem cells, myocytes, bone marrow, skeletal muscle as well as an array of other medical procedures, such as cardiac surgery, transplantation and/or preservation.
Cedars-sinai Medical Center
04/23/15
20150111126
new patent

Catalyst treatment for solid polymer electrolyte fuel cells


The high current density performance of solid polymer electrolyte fuel cells using certain alloy catalyst compositions can be improved via appropriate treatment of the catalyst composition with a fluoro-phosphonic acid compound. In particular, fuel cells employing carbon supported pt—co cathode catalyst compositions with relatively high co content benefit by treating the catalyst composition with 2-(perfluorohexyl) ethyl phosphonic acid..
Ford Motor Company
04/23/15
20150111116
new patent

Fuel cell system


A fuel cell system according to the present invention comprises a fuel gas supply system that supplies a fuel gas from a fuel supply source to a fuel cell that includes a stack including a plurality of cells, and a fuel off-gas circulation system that resupplies fuel off-gas to the stack. The fuel off-gas circulation system includes: a mixed fuel gas flow path formed such that a mixed fuel gas containing the fuel off-gas and the fuel gas flows in a direction along an inner surface of a manifold installed in the stack; and a point of merger where the fuel off-gas and the fuel gas merge with each other to produce the mixed fuel gas, the point of merger being arranged on one surface side of the manifold.
Toyota Jidosha Kabushiki Kaisha
04/23/15
20150111112
new patent

Fluorine-containing esters and methods of preparation thereof


A method for preparing fluorine-containing carboxylic acid esters is described in which a salt of a carboxylic acid is reacted with a fluorinated alkyl halide. The fluorine-containing carboxylic acid esters prepared by the method disclosed herein are particularly useful as electrolyte solvents for electrochemical cells, such as a lithium ion battery, where a high purity solvent is desired..
E. I. Du Pont De Nemours And Company
04/23/15
20150111108
new patent

Secondary battery


Provided is a secondary battery adopting an all-solid-state secondary cell structure with a storage layer sandwiched between a positive electrode layer and a negative electrode layer and which is superior to a conventional secondary battery with respect to at least one of volume, manufacturing, and positioning. The present invention provides a secondary battery including a single-layer secondary cell having a folded structure that a sheet-shaped single-layer secondary cell with a storage layer sandwiched between a positive electrode layer and a negative electrode layer is folded in two or four.
Guala Technology Co., Ltd.
04/23/15
20150111089
new patent

Apparatus for preventing overcharging of battery and battery comprising the apparatus


An apparatus preventing overcharging of a battery and a battery including the apparatus are provided. The apparatus includes holders interposed on respective gaps between battery cells to be stacked and an installation space formed between borders of adjacent holders.
Hyundai Motor Company
04/23/15
20150111083
new patent

Inner case of battery module assembly for vehicle's battery pack


Disclosed is an inner case of a battery module assembly in which four battery modules, each having a plurality of cylindrical secondary battery cells (hereinafter, also referred to as ‘cells’), are electrically connected in series. The inner case includes a side frame making contact with two facing sides among sides of the battery module assembly, an upper frame making contact with an upper surface of the battery module assembly, and an electrode post electrically connected to an electrode of the battery module assembly and located at a top of the upper frame.
Lg Chem, Ltd.
04/23/15
20150111082
new patent

Cell module assemblies


A method includes: assembling a thermal-exchange tube in a module housing for an energy storage pack; assembling cells in the module housing, wherein the thermal-exchange tube runs between rows of the cells; applying an adhesive that affixes the cells and the thermal-exchange tube to the module housing; curing a first portion of the adhesive by radiation, wherein a second portion of the adhesive is shielded from the radiation by the cells or the thermal-exchange tube; and curing at least the second portion of the adhesive by a chemical cure mechanism.. .
Tesla Motors, Inc.
04/23/15
20150111073
new patent

Battery pack unit integrating bus bar unit, cell monitor substrate and control unit


A battery pack unit includes: a plurality of battery cells each having an electrode; a battery pack constituted by the plurality of battery cells being laminated in a lamination direction; an electrode connecting member electrically connecting electrodes of mutually adjacent battery cells; a cell monitor substrate that monitors a state of every battery cell and a control unit electrically connected to the cell monitor substrate, receiving a signal transmitted from the cell monitor substrate. The cell monitor substrate and the control unit are arranged in the lamination direction and arranged in parallel with the electrode connecting member at a side of the electrode surface..
Denso Corportion
04/23/15
20150111072
new patent

Battery module


A battery module including a plurality of battery cells arranged in a row; a plurality of bus bars connecting the plurality of battery cells in series; and a short circuit member that is mechanically connected to a first battery cell among the plurality of battery cells and that is electrically connected to a second battery cell among the plurality of battery cells.. .
Samsung Sdi Co., Ltd.


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