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Cells patents



      
           
This page is updated frequently with new Cells-related patent applications. Subscribe to the Cells RSS feed to automatically get the update: related Cells RSS feeds. RSS updates for this page: Cells RSS RSS


Modular data center cooling

Zonit Structured Solutions

Modular data center cooling

Modular data center cooling

Cornell University

Ordered porous nanofibers, methods, and applications

Date/App# patent app List of recent Cells-related patents
02/26/15
20150059021
 Sugarcane bacilliform viral (scbv) enhancer and its use in plant functional genomics patent thumbnailnew patent Sugarcane bacilliform viral (scbv) enhancer and its use in plant functional genomics
Identification of new enhancer sequence has significant utility in the plant functional genomics. The sugarcane bacilliform badnavirus (scbv) transcriptional enhancer has been identified.
Dow Agrosciences Llc
02/26/15
20150059018
 Methods and compositions for producing drimenol patent thumbnailnew patent Methods and compositions for producing drimenol
The present invention relates to nucleic acids sequences derived from valeriana officinalis and/or persicaria hydropiper and encoding drimenol synthase polypeptides. The present invention also provides the amino acid sequences of the polypeptides.
Keygene N.v.
02/26/15
20150059015
 Fungal resistant plants expressing acd patent thumbnailnew patent Fungal resistant plants expressing acd
The present invention relates to a method of increasing resistance against fungal pathogens of the family phacosporaceae in plants and/or plant cells. This is achieved by increasing the expression of an acd protein or fragment thereof in a plant, plant part and/or plant cell in comparison to wild type plants, wild type plant parts and/or wild type plant cells.
Basf Plant Science Company Gmbh
02/26/15
20150059009
 Methods for making fully human bispecific antibodies using a common light chain patent thumbnailnew patent Methods for making fully human bispecific antibodies using a common light chain
A genetically modified mouse is provided, wherein the mouse expresses an immunoglobulin light chain repertoire characterized by a limited number of light chain variable domains. Mice are provided that express just one or a few immunoglobulin light chain variable domains from a limited repertoire in their germline.
Regeneron Pharmaceuticals, Inc.
02/26/15
20150058702
 Multi-level memory controller with probability-distribution-based encoding patent thumbnailnew patent Multi-level memory controller with probability-distribution-based encoding
A memory controller includes an encoder, a modulator, and a demodulator. A nonvolatile memory includes memory cells, each programmable to one of three or more levels.
Marvell World Trade Ltd.
02/26/15
20150058536
 Memory controller having state shaping engine and  operating same patent thumbnailnew patent Memory controller having state shaping engine and operating same
A memory controller includes a state shaping encoder that receives k-bit write data, selects a logical page with reference to state shape mapping information, and changes data of the logical page to decrease an occurrence probability of a high-order program state among program states used to program the k-bit data in multi-level memory cells.. .
Samsung Electronics Co., Ltd.
02/26/15
20150058390
 Storage of arbitrary points in n-space and retrieval of subset thereof based on a determinate distance interval from an arbitrary reference point patent thumbnailnew patent Storage of arbitrary points in n-space and retrieval of subset thereof based on a determinate distance interval from an arbitrary reference point
Systems and methods pertaining to nearness calculations of points in n-space. Among the embodiments is associating points of interest with point records in a data store, and efficient retrieval of subsets of those point records which meet arbitrary criteria.
02/26/15
20150058240
 Method and system for providing a virtual job market patent thumbnailnew patent Method and system for providing a virtual job market
The present invention relates to a method for providing a virtual job market on a network comprising an application server and clients and/or electronic message systems allowing to input and output information, wherein the method comprises the following steps: providing primary dimensions information on industries, career levels and functional areas; providing secondary dimensions information on salary ranges and/or geo-data and/or educational information and/or languages and/or special expertises, entering the primary and secondary dimensions information in a three dimensional data base on the application server; collecting information chunks of open jobs and candidate profiles, and placing the information chunks in a distinct cell or number of cells in the three dimensional database. Further, the present invention relates to a system for providing a virtual job market on a network comprising an application server and clients and/or electronic message systems including at least a first database comprising candidate profiles, a second database comprising salary information and a third database comprising job information, wherein the information available in the three databases is matched in a three dimensional database model..
Experteer Gmbh
02/26/15
20150057553
 Internal optical spectroscope and  real time in-situ diagnosis in living cells patent thumbnailnew patent Internal optical spectroscope and real time in-situ diagnosis in living cells
The present application relates to an internal optical spectroscope comprising: a needle sleeve insertable into and removable from targeted living tissue; a shaft housed by the needle sleeve including at least one v-shaped trough including an aft side and a next-to-aft side; a light source comprising variable light wave lengths of both visible and near infrared light; at least one light transmission fiber comprising a transmitting end; at least one light detector fiber comprising a receptive end; and data processor. The present application also relates to a method of performing an optical biopsy in situ..
United States Of America As Represented By The Secretary Of The Army (u.s Army)
02/26/15
20150057441
 Sequence-determined dna fragments encoding acetohydroxyacid synthase proteins patent thumbnailnew patent Sequence-determined dna fragments encoding acetohydroxyacid synthase proteins
The present invention provides dna molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The dna molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an utr or as a 3′ termination sequence, and are also useful in controlling the behavior of a gene in the chromosome, in controlling the expression of a gene or as tools for genetic mapping, recognizing or isolating identical or related dna fragments, or identification of a particular individual organism, or for clustering of a group of organisms with a common trait..
Ceres, Inc.
02/26/15
20150057371
new patent

Reversible, on-demand generation of aqueous two-phase microdroplets


The present invention provides methods of on-demand, reversible generation of aqueous two-phase microdroplets core-shell microbeads, microparticle preparations comprising the core-shell microbeads, and drug delivery formulation comprising the microparticle preparations. Because these aqueous microdroplets have volumes comparable to those of cells, they provide an approach to mimicking the dynamic microcompartmentation of biomaterial that naturally occurs within the cytoplasm of cells.
Ut-battelle, Llc
02/26/15
20150057368
new patent

Closed cell foams including poly-4-hydroxybutyrate and copolymers thereof


Methods to produce substantially closed cell foams with densities less than 0.75 g/cm3, and more preferably less than 0.5 g/cm3, without substantial loss of the polymer's weight average molecular weight, have been developed. The closed cells foams have an open cell content of generally less than 50%, and more preferably an open cell content of less than 20%, and the cells have a maximum diameter of less than 5 mm.
Tepha, Inc.
02/26/15
20150057367
new patent

Micro-particles containing a 3-d polymeric structure


Micro-sized particles having a polymeric structure of cells are provided. Also provided is a method of producing micro-sized particles having a polymeric structure comprising: (1) forming a homogenous solution by heating a mixture of a high molecular weight polymer and a low molecular weight material, wherein said low molecular weight material makes up at least about 50% by weight of the homogenous solution, (2) forming a dispersed solution by dispersing the homogenous solution formed in step (1) into an inert material, (3) cooling the dispersed solution to cause the high molecular weight polymer to phase separate from the low molecular weight material, (4) forming solid particles comprised of said low molecular weight material trapped inside a structure of cells of said high molecular weight polymer, and (5) removing the solid particles from the dispersed solution..
Bridgestone Corporation
02/26/15
20150057329
new patent

Compounds and methods for modulating expression apob


The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animals with increased potency and improved therapeutic index.
Isis Pharmaceuticals, Inc.
02/26/15
20150057217
new patent

Short designed peptides possessing selective actions against bacteria and cancer cells


Or a salt thereof. The invention further relates to use of the peptides as antibacterial agents, or antitumor agents, including the medical use of the peptide in treating infection and/or cancer, as well as their use as preservatives and antibacterial agents in other products, including personal care products such as skin topical treatments, cleansers, mouth washes, toothpastes, shampoo, body lotions and creams etc..
02/26/15
20150057188
new patent

Quantitative multiplex methylation-specific pcr


Methods are provided for diagnosing in a subject a condition, such as a carcinoma, sarcoma or leukemia, associated with hypermethylation of genes by isolating the genes from tissue containing as few as 50 to 1000 tumor cells. Using quantitative multiplex methylation specific pcr (qm-msp), multiple genes can be quantitatively evaluated from samples usually yielding sufficient dna for analyses of only 1 or 2 genes.
The Johns Hopkins University
02/26/15
20150057185
new patent

Reaction-based fluorescent probe for selective detection of carbon monoxide using metal-mediated carbonylation


Carbon monoxide (co) is a member of the gasotransmitter family that includes no and h2s and is implicated in a variety of pathological and physiological conditions. Whereas exogenous therapeutic additions of co to tissues and whole animals have been well studied, the real-time spatial and temporal tracking of co at the cellular level remains an open challenge.
The Regents Of The University Of California
02/26/15
20150057184
new patent

Cellular microarrays for screening differentiation factors


Provided is a microarray platform for the culture of cells atop combinatorial matrix mixtures; enabling the study of differentiation in response to a multitude of microenvironments in parallel.. .
The Regents Of The University Of California
02/26/15
20150057183
new patent

Method for the determination of the dna methylation level of a cpg position in identical cells within a tissue sample


Aspects of the present invention relate to the determination of the dna methylation level at one or more cpg position within cells of a defined type in a tissue sample. This methylation level is deduced from the total dna methylation level of all cells of the sample and from the content of said cells of interest.
Epigenomics Ag
02/26/15
20150057174
new patent

Differential diagnostic method and kit for infectious and parasitic diseases, using flow cytometry


The present invention relates to a differential diagnostic method using flow cytometry, performed by means of differential fluorescent marking of biological agents, such as cells and pathogens of interest, with fluorescent substances. The diagnostic method generally consists in performing fluorescent marking of biological agents with gradual concentrations of fluorescent substances, and in analysing the reactivity profile of igg1 to the biological agents.
Fundacao Oswaldo Cruz
02/26/15
20150057165
new patent

Microrna and use thereof in identification of b cell malignancies


Disclosed are nucleic acid sequences, including microrna sequences and cdna sequences, as well as vectors, dna libraries, microarrays, and recombinant cells comprising the nucleic acid sequences described herein. Methods of determining the b cell stage from which a b cell malignancy is derived.
Duke University
02/26/15
20150057163
new patent

Systems and methods for epigenetic sequencing


The present invention generally relates to microfluidics and/or epigenetic sequencing. In one set of embodiments, cells contained within a plurality of microfluidic droplets are lysed and the dna (e.g., from nucleosomes) within the droplets are labeled, e.g., with adapters containing an identification sequence.
President And Fellows Of Harvard College
02/26/15
20150057009
new patent

Method and apparatus of dynamic spectrum sharing in cellular networks


According to a disclosed method, an mme in a network analyzes kpis from the cells it serves and based on the kpis, it decides to engage in sharing. The mme then contacts a sharing entity (se) to announce that it wants to supply spectrum for sharing.
Alcatel-lucent Usa Inc.
02/26/15
20150056999
new patent

Method for providing information in a cellular wireless communication system


The present invention relates to a method for providing information in a cellular wireless communication system, comprising the steps of: detecting a radio link failure (rlf) for a mobile station while connected to a first cell; re-establishing the connection in a second cell; and providing information about said radio link failure (rlf) only to cells supporting the same radio access technology (rat) as said first cell. Furthermore, the invention also relates to a method in a mobile station, a method in a base station, a computer program, a computer program product, a mobile station device and a base station device..
Huawei Technologies Co., Ltd.
02/26/15
20150056997
new patent

Methods and improved cell re-selection with autonomous search function


Apparatus and methods are described for identifying candidate cells on at least one frequency, where each of the candidate cells is associated with a cell quality, storing information related to each of the candidate cells in a candidate list, sorting the candidate list, and decoding a master information block (mib) and one or more system information blocks (sibs) for a subset of the candidate cells based on the sorting.. .
Qualcomm Incorporated
02/26/15
20150056994
new patent

Selective joinder of machine-type communication user equipment with wireless cell


Embodiments are described herein for selective joinder of wireless cells by machine-type communication (“mtc”) user equipment (“ue”). An mtc ue may detect a plurality of wireless cells, each provided by an evolved node b (“enb”).
Intel Corporation
02/26/15
20150056989
new patent

Method and identifying microcells in macrocells in wireless communication systems, and handover method and system using same


The present invention relates to a method for identifying a microcell in a macrocell including the steps of: a user equipment (ue) obtaining a physical identity of the microcell by performing cell search on an adjoining microcell; and the ue identifying the microcell by using a specific pattern of a sub-frame transmitted by the microcell.. .
Samsung Electronics Co., Ltd.
02/26/15
20150056908
new patent

Modular data center cooling


A modular arrangement is provided for housing electronic equipment and associated cooling structure in a data center environment. The modular units provide cooling air on an as-needed basis to individual pieces of equipment by way of individual plenums and associated valves.
Zonit Structured Solutions, Llc
02/26/15
20150056798
new patent

Methods of forming metal oxide


Some embodiments include methods of forming memory cells. Metal oxide may be deposited over a first electrode, with the deposited metal oxide having a relatively low degree of crystallinity.
Micron Technology, Inc.
02/26/15
20150056749
new patent

Atomic layer deposition of metal oxide materials for memory applications


Embodiments of the invention generally relate to nonvolatile memory devices, such as a reram cells, and methods for manufacturing such memory devices, which includes optimized, atomic layer deposition (ald) processes for forming metal oxide film stacks. The metal oxide film stacks contain a metal oxide coupling layer disposed on a metal oxide host layer, each layer having different grain structures/sizes.
Sandisk 3d Llc
02/26/15
20150056744
new patent

Thin film structures and devices with integrated light and heat blocking layers for laser patterning


Selective removal of specified layers of thin film structures and devices, such as solar cells, electrochromics, and thin film batteries, by laser direct patterning is achieved by including heat and light blocking layers in the device/structure stack immediately adjacent to the specified layers which are to be removed by laser ablation. The light blocking layer is a layer of metal that absorbs or reflects a portion of the laser energy penetrating through the dielectric/semiconductor layers and the heat blocking layer is a conductive layer with thermal diffusivity low enough to reduce heat flow into underlying metal layer(s), such that the temperature of the underlying metal layer(s) does not reach the melting temperature, tm, or in some embodiments does not reach (tm)/3, of the underlying metal layer(s) during laser direct patterning..
Applied Materials, Inc.
02/26/15
20150056742
new patent

Annealing for damage free laser processing for high efficiency solar cells


Annealing solutions providing damage-free laser patterning utilizing auxiliary heating to anneal laser damaged ablation regions are provided herein. Ablation spots on an underlying semiconductor substrate are annealed during or after pulsed laser ablation patterning of overlying transparent passivation layers..
Solexel, Inc.
02/26/15
20150056735
new patent

Method for manufacturing membrane layers of organic solar cells by roll to roll coating


A method for manufacturing membrane layers of organic solar cells by roll to roll coating utilizes a roll to roll process for manufacturing an electron transferring layer and an active layer of the organic solar cells is disclosed. The roll to roll process adopted by the method cooperates with a particular solvent and accompanies a parameter control such as temperature and processing time during the sintering and baking steps.
Atomic Energy Council-institute Of Nuclear Energy Research
02/26/15
20150056705
new patent

Methods and compositions for treatment of a genetic condition


Methods and compositions for genetic alteration of cells are provided.. .
Sangamo Biosciences, Inc.
02/26/15
20150056704
new patent

Methods and products for biasing cellular development


Methods are described that bias cells, such as potent and multipotent stem cells, by transfection with a nucleic acid sequence, to differentiate to a desired end-stage cell or a cell having characteristics of a desired end-stage cell. In particular embodiments, human neural stem cells are transfected with vectors comprising genes in the homeobox family of transcription factor developmental control genes, and this results in a greater percentage of resultant transformed cells, or their progeny, differentiating into a desired end-stage cell or a cell having characteristics of a desired end-stage cell..
University Of Central Florida Research Foundation, Inc.
02/26/15
20150056703
new patent

Fiber scaffolds for enhancing cell proliferation in cell culture


A substrate for culturing cells that includes at least one fiber scaffold adapted to be contained within a disposable or non-disposable bioreactor, wherein the fiber scaffold further includes polymer fibers that have been created by electrospinning, and wherein the orientation of the fibers in the scaffold relative to one another is generally parallel, random, or both.. .
02/26/15
20150056702
new patent

Method and kit for culturing stem cells


A method is provided, including adding a phthalide to a stem cell medium to provide a phthalide-containing medium, and then culturing a stem cell using the phthalide-containing medium. The use of a phthalide in a medium for culturing stem cells optionally maintains the pluripotency of stem cells.
China Medical University
02/26/15
20150056701
new patent

Cell suspension medium and cell suspension medium additive for the three dimensional growth of cells


The present invention relates to a cell culture medium additive comprising a xanthan polysaccharide and a mannan polysaccharide, such as a glucomannan or a galactomannan, that supports the growth of cells in suspension, and to a cell culture medium containing the additive. More particularly, but not exclusively, the present invention relates to a cell culture medium additive that supports the formation of multicellular bodies such as spheroids, and prevents sedimentation of cells without adversely affecting the physical properties of the cell culture medium..
The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Hol
02/26/15
20150056698
new patent

Primate embryonic stem cells


A purified preparation of primate embryonic stem cells is disclosed. This preparation is characterized by the following cell surface markers: ssea-1 (−); ssea-4 (+); tra-1-60 (+); tra-1-81 (+); and alkaline phosphatase (+).
Wisconsin Alumni Research Foundation
02/26/15
20150056697
new patent

Pluripotent stem cells and stimulating and extracting non-embryonic pluripotent stem cells from mammal blood and using reconstituted pluripotent stem cells to treat diseases including chronic obstructive pulmonary disease


Stimulating tissue resident pluripotent stem cells in a manner that the respective subject (e.g., human) acts as its own sterile bioreactor for in vivo stem cell proliferation thus eliminating the need to isolate, cultivate, maintain, proliferate and release stem cells ex vivo. The stimulation mobilizes excess pluripotent stem cells into the peripheral vasculature where the pluripotent stem cells can either migrate to damaged tissues and/or be harvested by simple venipuncture, thus eliminating potential morbidity and mortality elicited from harvesting tissue from solid tissue sites.
Royal Medical Group, Pllc
02/26/15
20150056691
new patent

Apparatus and methods for cell isolation


A unitary apparatus for isolating cells from adipose tissue including a lipid separation processor with a dispersing head equipped with a plurality of ports and a digestion chamber for dissociation of the constituent cells disposed in adipose tissue. The lipid separating apparatus is useful for the separation of lipids and adipocytes from a mixed cell population.
Ingeneron Incorporated
02/26/15
20150056688
new patent

Dual path immunoassay device


Systems include test cells with sorbent material in a t-shape and defining a first flow path for a solution and a second flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules located at the junction of the t. A housing houses the sorbent material and defines a first hole adjacent an end of the first flow path for receiving the solution and a second hole adjacent an end of the second flow path for receiving the sample..
Chembio Diagnostics Systems, Inc.
02/26/15
20150056678
new patent

Disease therapy using dying or dead cells


A method of treating a disease characterized by a pathological immune response in a subject in need thereof is disclosed. The method comprises administering to the subject a therapeutically effective amount of a cell preparation which comprises dying or dead leukocytes, the dying or dead leukocytes being capable of suppressing the pathological immune response, thereby treating the disease in the subject..
Enlivex Therapeutics Ltd.
02/26/15
20150056665
new patent

Method of producing chemical by continuous fermentation and continuous fermentation apparatus


A method of producing a chemical includes culturing cells in a culture solution in a fermentor to ferment a feedstock to produce a chemical; supplying the culture solution containing the chemical produced in the culturing to a plurality of separation membrane units arranged in parallel; filtering the culture solution supplied in the supplying to separate a permeate containing the chemical; refluxing a retentate that is not filtered in the filtering to the fermentor; and supplying a gas containing oxygen to the plurality of separation membrane units while a supply amount is changed to at least two different values to perform scrubbing, wherein the supply amount and supply time of the gas containing oxygen supplied in the culturing and the supplying the gas are set so that a kla value is within a predetermined range from an optimal kla value for the cells cultured in the culturing.. .
Toray Industries, Inc.
02/26/15
20150056664
new patent

Variants of glycoside hydrolases


The present invention relates to variants of a parent glycoside hydrolase, comprising a substitution at one or more positions corresponding to positions 21, 94, 157, 205, 206, 247, 337, 350, 373, 383, 438, 455, 467, and 486 of amino acids 1 to 513 of seq id no: 2, and optionally further comprising a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of seq id no: 2 a substitution at one or more positions corresponding to positions 8, 22, 41, 49, 57, 113, 193, 196, 226, 227, 246, 251, 255, 259, 301, 356, 371, 411, and 462 of amino acids 1 to 513 of seq id no: 2, wherein the variants have glycoside hydrolase activity. The present invention also relates to nucleotide sequences encoding the variant glycoside hydrolases and to nucleic acid constructs, vectors, and host cells comprising the nucleotide sequences..
Novozymes Inc.
02/26/15
20150056661
new patent

Cells, nucleic acids, enzymes and use thereof, and methods for the production of sophorolipids


The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.. .
Evonik Degussa Gmbh
02/26/15
20150056660
new patent

Cells, nucleic acids, enzymes and use thereof, and methods for the production of sophorolipids


The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.. .
Evonik Degussa Gmbh
02/26/15
20150056659
new patent

Cells, nucleic acids, enzymes and use thereof, and methods for the production of sophorolipids


The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.. .
Evonik Degussa Gmbh
02/26/15
20150056658
new patent

Cells, nucleic acids, enzymes and use thereof, and methods for the production of sophorolipids


The invention relates to cells, nucleic acids, and enzymes, the use thereof for producing sophorolipids, and methods for producing sophorolipids.. .
Evonik Degussa Gmbh
02/26/15
20150056657
new patent

Method of producing recombinant high molecular weight vwf in cell culture


Among other aspects, the present invention relates to cell culture conditions for producing high molecular weight vwf, in particular, highly multimericwf with a high specific activity and adamts13 with a high specific activity. The cell culture conditions of the present invention can include, for example, a cell culture medium with an increased copper concentration and/or cell culture supernatant with a low ammonium (nh4+) concentration.
Baxter Healthcare Sa
02/26/15
20150056656
new patent

Method for reduction of 1->2 reading frame shifts


Herein is reported a method for the recombinant production of a polypeptide, which comprises the dipeptide ar, characterized in that the method comprises the recovering of the polypeptide from the cells or the cultivation medium of a cultivation of a cell comprising a nucleic acid encoding the polypeptide and thereby producing the polypeptide, whereby the dipeptide ar comprised in the polypeptide is encoded by the oligonucleotide gca cgt, or the oligonucleotide gcg cgt, or the oligonucleotide gcc cgt.. .
Hoffmann-la Roche Inc.
02/26/15
20150056655
new patent

Expression constructs and methods for expressing polypeptides in eukaryotic cells


The invention relates to an expression construct for the expression of polypeptides in host cells using alternative splicing. The expression construct can be used for the expression of polypeptides such as antibodies, antibody fragments and bispecific antibodies by expressing the gene products required for protein expression at the ratio leading to the highest titres or the best product quality profile..
Glenmark Pharmaceuticals S.a.
02/26/15
20150056652
new patent

Methods for increasing homologous recombination of a nucleic acid sequence


The present invention relates to methods for increasing homologous recombination of a nucleic acid sequence introduced into a host cell, comprising: (a) introducing into a population of filamentous fungal host cells a first nucleic acid sequence encoding a recombination protein and a second nucleic acid sequence comprising one or more regions which are homologous with the genome of the filamentous fungal host cell, wherein (i) the recombination protein promotes the recombination of the one or more regions with the corresponding homologous region in the host's genome to incorporate the second nucleic acid sequence by homologous recombination, and (ii) the number of host cells comprising the incorporated second nucleic acid sequence in the population is increased at least 20% compared to the same population without the first nucleic acid sequence; (b) and isolating from the population a filamentous fungal cell comprising the incorporated second nucleic acid sequence.. .
Novozymes, Inc.
02/26/15
20150056649
new patent

Method for quantifying cell of interest in blood, and evaluating system for quantifying said cell


A method for quantifying cells of interest potentially contained in a blood-derived sample in cases of their quantification after separation from the blood-derived sample may enable accurate quantification of the cells without causing underestimation of the cell number. The quantification method is a method for quantifying specific cells of interest, the method may include: (a) separating a blood-derived sample containing a known number (p0) of specific resin particles p into at least two layers including a layer of erythrocytes and a layer of cells other than erythrocytes; (b) extracting the layer of cells other than erythrocytes and counting the number of cells of interest and the number (p1) of the resin particles therein; and (c) correcting the number of cells of interest by multiplying the number of cells of interest by p0/p1..
Konica Minolta, Inc.
02/26/15
20150056647
new patent

Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells


The invention relates to methods for differentiating progenitor cells into insulin producing pancreatic islet cells and compositions and methods for using such cells.. .
Vesta Therapeutics Inc.
02/26/15
20150056644
new patent

Continuous culture apparatus with mobile vessel, allowing selection of fitter cell variants and producing a culture in a continuous manner


A method and device for growing plant, animal or stem cells in a continuous manner.. .
02/26/15
20150056640
new patent

Reagents and methods for detecting a polymorphic protein


The present invention provides antibodies that differentially react with allelic variants of a polymorphic protein, methods of identifying same, an antigen binding fragment comprised therein, proteins, cells, viral particles, compositions, and kits comprising same. The invention also provides methods for determining a haptoglobin type of a subject and methods for testing a subject for susceptibility to diabetic complications..
Rappaport Family Institute For Research In The Medical Sciences
02/26/15
20150056636
new patent

Transgenic immunodeficient mouse expressing human sirp-alpha


The present invention provides a transgenic mouse which comprises a deficiency for murine t lymphocytes, b lymphocytes and nk cells, a deficiency for murine mhc class i and mhc class ii molecules, and a functional xenogenic sirpα transgene. This mouse is useful for in vivo screening of various compounds, including immuno-therapeutic agents and vaccines.
Institut Pasteur
02/26/15
20150056633
new patent

Detection of glutathionylated proteins


The present invention, in some aspects, relates to systems and methods for determining oxidized proteins, including glutathionylated proteins such as s-glutathionylated proteins. The systems and methods of the invention can be used in vitro (e.g., in cell or tissue culture) or in vivo, for example, to diagnose a person having an oxidative stress condition.
Universiteit Maastricht
02/26/15
20150056631
new patent

Methods and compositions for diagnosing disease


The present invention relates to methods and compositions for diagnosing a disease or disorder in a subject by introducing into cells of the subject a diagnostic gene switch construct and monitoring expression of a reporter gene. The invention further relates to methods and compositions for monitoring the progression of a disease or disorder or the effectiveness of a treatment for a disease or disorder..
Intrexon Corporation
02/26/15
20150056630
new patent

Dna controlling mir-140 expression, and screening drugs using said dna


An object of the present invention is to provide dna which regulates the expression of mir-140, a reporter vector which contains the dna, cells and animals into which the reporter vector is introduced and a screening system for drugs which control the expression of mir-140 and is also to contribute in the development of new therapeutic agents for cartilage diseases such as osteoarthritis and intervertebral disk degeneration using the screening system. The dna sequence according to the present invention is able to express any gene in a site where mir-140 is expressed and, in addition, it is also able to be utilized for screening a drug which regulates the expression of mir-140.
Nippon Zoki Pharmaceutical Co., Ltd.
02/26/15
20150056622
new patent

Editing profiling of pde8a pre -mrna: use as specific biomarker of adars activities in human tissues to diagnose and to predict and assess therapeutic efficacy and/or efficiency or potential drug side effects


The present invention relates to the use of the editing profile of pde8a pre-mrna as a specific bio marker of adars activities in evolved primate, particularly in human tissues. The present invention also relates to an in vitro method for predicting in human an alteration of the mechanism of the adars catalysed pre-mrna editing of target genes, by analysing the pde8a pre-mrna editing profile in a peripheral tissue sample containing cells expressing said pde8a pre-mrna, such as blood sample.
Biocortech
02/26/15
20150056614
new patent

Devices and methods of cell capture and analysis


The present invention provides a device for isolating target biomolecules or cells from samples, particularly biological samples. In particular, the device comprises a loading mixture, which contains the biological sample and a first binding entity that specifically binds to the target biomolecule or target cell; and a micro-channel coated with a second binding entity that binds directly or indirectly to the first binding entity.
Biocept, Inc.
02/26/15
20150056610
new patent

Monitoring and inhibiting human immunodeficiency virus infection by modulating hmgb1 dependent triggering of hiv-1 replication and persistence


Compositions and methods for modulating human immunodeficiency virus (hiv) infection involving substances that inhibit the ability of high mobility box 1 (hmgb1) protein to interact with natural killer (nk) cells. Therapeutic compositions comprising antibodies and drugs, such as glycyrrhizin, which bind to hmgb1.
Institut Pasteur
02/26/15
20150056608
new patent

Method for treating infectious diseases using emissive energy


The present invention relates to the treatment of infectious diseases, specifically by extracorporeally eradicating the pathogen. This invention comprises methods for the extracorporeal treatment of infectious diseases that will remove infectious pathogens (leukemia cells, bacteria, viruses, or fungi causing a septicemia, metastatic cancer cells, target protein, viruses, parasites, fungi and prions) in humans by targeting such pathogens with a laser or other high-energy source of emissive radiation.
Marv Enterprises, Llc
02/26/15
20150056535
new patent

Multi-layer coating


Wherein p(o2)in, p(o2)ex, dm, and do are as defined herein. The coating may be used in high temperature devices, particularly for coating interconnect materials in solid oxide electrolytic devices, including solid oxide fuel cells (sofcs) and solid oxide electrolysis cells (soecs)..
02/26/15
20150056534
new patent

Membrane electrode assemblies and associated fuel cells


The description relates to fuel cells and fuel cell systems. One example includes at least one multi cell membrane electrode assembly (mcmea).
Emergent Power Inc.
02/26/15
20150056528
new patent

Reforming chamber with multiple electrodes to generate hydrogen


Embodiments described herein generally relate to a reforming chamber housing a hydrocarbon-water mixture and receiving a control voltage signal to cause molecular breakdown of the mixture and create a feed of hydrogen and carbon and dioxide that can be supplied to fuel cells. The reforming chamber includes multiple electrodes positioned across from a ground plane inside a cylindrical support structure.
19th Space Energy, Llc
02/26/15
20150056521
new patent

Lithium ion battery electrolytes and electrochemical cells


An electrolyte solution for a lithium ion battery, wherein the electrolyte solution includes water.. .
3m Innovative Properties Company
02/26/15
20150056495
new patent

Battery pack


The battery pack according to the present invention includes a plurality of battery cells generating an electric current to which leads are connected in order to supply the generated electric current. At least two of the leads of the battery cells are welded in the plurality of battery cells.
Lg Electronics Inc.
02/26/15
20150056492
new patent

Cross-linked multilayer porous polymer membrane battery separators


A cross-linkable polyolefin composition (polyethylene, polypropylene or an ethylene-propylene copolymer) is coextruded with ultrahigh molecular weight polyethylene to form two-layer separator membranes, or three-layer separator membranes, for lithium-ion battery cells. In three-layer separator membranes, the cross-linkable polyolefin is formed as the outer faces of the separator for placement against facing surfaces of cell electrodes.
Gm Global Technology Operations Llc
02/26/15
20150056489
new patent

Laminated battery cell and methods for creating the same


Electrodes with a multilayer or monolayer composite separator are described. The multilayer composite separator comprises multiple individual composite separator layers.
A123 Systems, Llc
02/26/15
20150056483
new patent

Power supply device


A power supply device (1) includes a battery cell assembly (2) being an assembly of battery cells (3) each having electrodes (4), a battery connecting block (10) placed on a side of the battery cell assembly (2) where the electrodes (4) are located and including a case body (11) including terminal fixing portions (12, 13) and a thermistor inserting portion (20), terminals (32, 30) fixed to the corresponding terminal fixing portions (12, 13), and a thermistor (31) disposed in the thermistor inserting portion (20) and configured to detect a temperature of the battery cells (3), and a thermistor wire (w2) drawn from the thermistor (31) to extend along the thermistor inserting portion (20) and fixed to the case body (11) by a binding band (35).. .
Yazaki Corporation
02/26/15
20150056482
new patent

Battery pack with a fire preventing agent


A battery pack having one or more battery cells, a shell enclosing the one or more battery cells, wherein at least part of the shell is separated in space with one or more battery cells, and a fire preventing and restricting agent placed between the shell and one or more battery cells. The fire preventing and restricting agent includes thermally expandable agent which is capable of preventing, retarding and/or extinguishing a fire in the battery pack by filling the space between the shell and one or more battery cells..
Valmet Automotive Oy
02/26/15
20150056479
new patent

Method for connecting battery cells in a battery, battery, and monitoring device


A method for connecting battery cells in a battery is provided, the battery including at least one measuring battery cell and at least one standard battery cell in a series connection, the standard battery cell having at least a nominal capacity which is greater than a nominal capacity threshold, the measuring battery cell having a nominal capacity which is less than the nominal capacity threshold, the measuring battery cell having a switchable bypass, the method including: monitoring a state of charge of the at least one measuring battery cell; and bypassing the at least one measuring battery cell using the switchable bypass if the state of charge of the at least one measuring battery cell drops below a predefined state of charge threshold.. .
Robert Bosch Gmbh
02/26/15
20150056471
new patent

Ordered porous nanofibers, methods, and applications


Described herein are nanofibers and methods for making nanofibers that have a plurality of pores. The pores have of any suitable size or shape.
Cornell University
02/26/15
20150056372
new patent

Separation membrane manufacturing method


Provided is a separation membrane manufacturing method capable of easily manufacturing a dense separation membrane. The separation membrane manufacturing method comprises a membrane forming step of forming a separation membrane precursor containing a separation membrane precursor solution on the surface of cells formed in a porous monolith substrate; and a drying step of performing ventilation drying by passing hot air through the cells having the separation membrane precursor in the monolith substrate to dry the separation membrane precursor.
Ngk Insulators, Ltd.
02/26/15
20150056301
new patent

Peptides and peptidomimetics in combination uses and treatments for cancer patient subpopulations


This invention provides compounds including peptides and peptidomimetics that can be used to treat cell proliferative disorders, such as those associated with benign and malignant tumor cells. While the invention is not limited to any particular mechanism, the compounds of the invention appear to function at least in part by inhibiting g2 cell cycle checkpoint.
Canbas Co., Ltd.
02/26/15
20150056295
new patent

Cellular extracts


The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products..
Regenics As
02/26/15
20150056290
new patent

Microsphere compositions, preparation method and applications thereof


A cell carrying microsphere composition, wherein the microsphere composition comprises a microspheric core comprising a triblock copolymer matrix a-b-a wherein a is selected from poly(lactide-co-glycolide) (plga) or polylactide (pla) and b is poloxamer or poloxamine, wherein the microspheric core is coated with a cell adhesion coating and further comprises whole cells or cell fragments bonded to the cell adhesion coating, a process for the preparation of a cell carrying microsphere composition, and applications thereof.. .
Inserm (institut National De La Sante Et De La Recherche Medicale)
02/26/15
20150056266
new patent

Cell cultivation in chitosan alginate hydrogel beads


The present invention relates to a hydrogel matrix comprising cartilage-forming cells wherein alginate, chitosan and cartilage-forming cells are mixed and subsequently polymerised into beads.. .
Universite De Liege
02/26/15
20150056253
new patent

Engineered nucleic acids and methods of use thereof


Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to kill or reduce the growth of microorganisms. Such compositions and methods include the use of modified messenger rnas, and are useful to treat or prevent microbial infection, or to improve a subject's heath or wellbeing..
Moderna Therapeutics, Inc.
02/26/15
20150056252
new patent

Composition and diagnosis and immunotherapy of lung cancer


The present invention includes compositions and methods for the diagnosis and treatment of lung cancer with a recombinant tumor-associated antigen loaded antigen presenting cell that generates a cytotoxic t lymphocyte specific immune response to at least one of sp17, akap-4, or pttg1 expressed by one or more lung cancer cells.. .
Texas Tech University System
02/26/15
20150056246
new patent

Subunit vaccine delivery platform for robust humoral and cellular immune responses


The present invention relates to a probiotic cell transformed with a construct suitable to overexpress and display on the surface of the probiotic cell a fusion protein comprising at least a portion of a transport protein coupled to at least a portion of one or more antigenic proteins or peptides. Probiotic-derived vesicles displaying this fusion protein as well as methods of inducing an immune response using the probiotic cells or vesicles are also disclosed..
Cornell University
02/26/15
20150056234
new patent

Hpv epitopes targeted by t cells infiltrating cervical malignancies for use in vaccines


The present invention relates to novel cd4+ and cd8+ t cell epitopes that are specific for hpv-specific e6 and e7 oncoproteins, to peptides comprising these novel t cell epitopes, and to (vaccine) compositions comprising these peptides for use in methods for the prevention and/or treatment of hpv related diseases. Preferred epitopes are recognized by a t cell that infiltrates a cervical neoplastic lesion or by a t cell from a draining lymph node, and are presented by an hla-dq or hla-dp molecule, or an hla-b..
Academisch Ziekenhuis Leiden H.o.d.n. Lumc
02/26/15
20150056228
new patent

Methods and materials for generating t cells


The document provides to methods and materials for generating t cells (e.g., antigen-specific cd4+ t cells). For example, methods and materials for using nested mhc class ii epitopes as vaccines to generate activated cd4+ t cells in vivo or as reagents to generate activated cd4+ t cells ex vivo are provided..
Mayo Foundation For Medical Education And Research
02/26/15
20150056225
new patent

Hla class ii deficient cells, hla class i deficient cells capable of expressing hla class ii proteins, and uses thereof


The invention provides isolated primate cells preferably human cells that comprise a genetically engineered disruption in a human leukocyte antigen (hla) class ii-related gene, which results in deficiency in mhc class ii expression and function. This invention also provides isolated cells further comprising a genetically engineered disruption in a beta-2 microglobulin (b2m) gene, which results in hla class i/class ii deficiency.
University Of Washington Through Its Center For Commercialization
02/26/15
20150056219
new patent

Methods and compositions for cancer therapy using mutant light molecules with increased affinity to receptors


Methods and compositions are disclosed to target tumor cells with embodiments of the light proteins linked fused or conjugated to a targeting agent. These compositions bind to both human and mouse receptors with affinity sufficient to conduct preclinical and clinical trials, and with increased affinity as compared to the wild type human light protein.
The University Of Chicago
02/26/15
20150056214
new patent

Monoclonal antibodies that bind b7h6 and uses thereof


Disclosed are monoclonal antibodies that specifically bind to the b7 family member b7h6, including antibodies capable of inhibiting the interaction of b7h6 with nkp30. Also disclosed are anti-b7h6 antibody-drug conjugates comprising an anti-b7h6 monoclonal antibody conjugated to a therapeutic agent.
Institut National De La Sante Et De La Recherche Medicale
02/26/15
20150056204
new patent

Dr5 receptor agonist combinations


The present invention includes apoptotic compositions and methods for inducing apoptosis of cancer cells independent of nk cells. An apoptotic composition comprises a cooperative combination of antibodies that specifically bind to human dr5, or a cooperative combination of an anti-dr5 antibody and trail.
Amgen Inc.
02/26/15
20150056201
new patent

Methods for detecting th1 cells


The inventors discovered that the adhesion molecule car, known to be localized in intracellular adhesion sites, functioned as an adhesion molecule for activated lymphocytes. Further, the inventors identified carl, a novel car ligand expressed in lymphocytes, and clarified that the ligand was expressed selectively in th1 cells.
Eisai R&d Management Co., Ltd.
02/26/15
20150056198
new patent

Aberrant cell-restricted immunoglobulins provided with a toxic moiety


Described are immunoglobulins provided with a toxic moiety, comprising at least an immunoglobulin variable region that specifically binds to an mhc-peptide complex preferentially associated with aberrant cells. These immunoglobulins provided with a toxic moiety are preferably used in selectively modulating biological processes.
Apo-t B.v.
02/26/15
20150056197
new patent

Vaccines against hpv


The present invention relates to therapeutic compounds, such as vaccines against human papillomavirus (hpv) and in particular to dna vaccines against hpv16 or hpv18. The invention further relates to protein construct encoding homodimeric peptides, which peptides may be released from a dna vaccine or used separately.
Vaccibody As
02/26/15
20150056195
new patent

Compositions and methods for inihibiting tumorigenicity of senescent cancer cells induced by chemotherapy


The invention relates to the field of oncology and to chemotherapy resistance and relapse. Thus the invention provides compositions and methods for inhibiting tumorigenicity of senescent cancer cells induced by a chemotherapeutic agent.
Inserm (institut National De La Sante Et De La Recherche Medicale)
02/26/15
20150056191
new patent

Igf1 biomarker for igf1r inhibitor therapy


The present invention provides, inter alia, methods for treating tumors that are sensitive to an igf1r inhibitor. The tumor are determined to be sensitive if the level of igf1 mrna expression in the tumor cells, relative to one or more reference genes, reaches a certain threshold level.
Merck Sharp & Dohme Corp.
02/26/15
20150056184
new patent

Protein belonging to the tnf superfamily involved in signal transduction, nucleic acids encoding same and methods of use thereof


A method of modulating immune response in an animal is disclosed. Such a method interacting the immature dendritic cells from the animal with an antigen ex vivo so that the immature dendritic cells present the antigen on their surfaces, inducing maturation of the immature dendritic cells ex vivo, and contacting the mature dendritic cells ex vivo with a modulator comprising trance, conservative variants thereof, fragments thereof, analogs or derivatives thereof, or a fusion protein comprising the amino acid sequence of trance, conservative variants thereof, or fragments thereof.
The Rockefeller University
02/26/15
20150056174
new patent

Self-cleaving ribozymes and uses thereof


In certain embodiments, the disclosure relates to compositions and methods relating to a ribozyme-based gene regulation system that functions in mammalian cells. In certain specific embodiments, the disclosure relates to schistosome self-cleaving rna mutant motifs..
Children's Medical Center Corporation
02/26/15
20150056170
new patent

Placental stem cells, methods for isolating same and use thereof


The present description relates to an isolated population of human placental pluripotent stem cells or an isolated human placental pluripotent stem cell, positive for human leucocyte antigen-g (hla-g), a migration marker and at least one pluripotent stem cell marker. The present description further provides a method for isolating human placental pluripotent stem cells.
Sct&b Inc.
02/26/15
20150056167
new patent

Peptides, derivatives and analogs thereof, and methods of using same


Human proislet peptides (hip) and hip analogs and derivatives thereof, derived from or homologous in sequence to the human reg3a protein, chromosome 2p12, are able to induce islet neogenesis from endogenous pancreatic progenitor cells. Human proislet peptides are used either alone or in combination with other pharmaceuticals in the treatment of type 1 and type 2 diabetes and other pathologies related to aberrant glucose, carbohydrate, andor lipid metabolism, insulin resistance, overweight, obesity, polycystic ovarian syndrome, eating disorders and the metabolic syndrome..
Curedm Group Holdings, Llc
02/26/15
20150056163
new patent

Leukotoxin e/d as a new anti-inflammatory agent and microbicide


The present invention relates to methods for preventing or treating human immunodeficiency virus (hiv) infection, inflammatory conditions, and graft-versus-host-disease (gvhd) in a subject. Therapeutic compositions of the present invention comprise leukocidin e (luke) and/or d proteins or polypeptides.
New York University
02/26/15
20150056161
new patent

Regeneration of endogenous myocardial tissue


This invention provides a method of treating a disorder of a subject's heart involving loss of cardiomyocytes which comprises administering to the subject a composition comprising an amount of a human stromal derived factor-1 and an amount of a human granulocyte-colony stimulating factor, the composition being administered in an amount effective to cause proliferation of cardiomyocytes within the subject's heart so as to thereby treat the disorder. This invention also provides a method of treating a subject suffering from a disorder of a tissue involving loss and/or apoptosis of cells of the tissue which comprises administering to the subject a composition comprising an amount of an agent which induces phosphorylation and/or activation of protein kinase b, or an agent which induces phosphorylation and/or activation of an extracellular signal-regulated protein kinase, or an agent which induces activation of cxcr4..
The Trustees Of Columbia University In The City Of New York
02/26/15
20150056160
new patent

Chemically induced intracellular hyperthermia


An invention relating to therapeutic pharmacological agents and methods to chemically induce intracellular hyperthermia and/or free radicals for the diagnosis and treatment of infections, malignancy and other medical conditions. The invention relates to a process and composition for the diagnosis or killing of cancer cells and inactivation of susceptible bacterial, parasitic, fungal, and viral pathogens by chemically generating heat, and/or free radicals and/or hyperthermia—inducible immunogenic determinants by using mitochondrial uncoupling agents, especially 2,4 dinitrophenol and, their conjugates, either alone or in combination with other drugs, hormones, cytokines and radiation..
St. Jude Pharmaceuticals, Inc.
02/26/15
20150056157
new patent

Vascular delivery systems


The site-specific expression of selectins on endothelial cells of blood vessels during angiogenesis provides an opportunity to target anti-cancer drugs to the vascular endothelium to extend the range of the therapeutic effect. This invention describes an innovative drug targeting strategy for the selective delivery of the anticancer drugs to endothelial cells by means of polymer-drug conjugates modified with a carbohydrate ligand for the vascular selectins.
Ben-gurion University Of The Negev Research And Development Authority
02/26/15
20150056144
new patent

Encapsulated diagnostics and therapeutics in nanoparticles - conjugated to tropic cells and methods for their use


A therapeutic or diagnostic delivery vehicle is provided. The delivery vehicle may include one or more particles, such as microparticles, nanoparticles and stimuli-responsive particles, conjugated to a tropic cell that targets at least one pathological entity or site.
City Of Hope
02/26/15
20150056143
new patent

Light-guiding hydrogel devices for cell-based sensing and therapy


A hydrogel-lightguide based sensory system susceptible to a stimulus signal produced by ambient and stimulating sensory cells embedded in a hydrogel body of the system. Sensory cells generate an optical signal (in response to a user-defined triggering with excitation light or, alternatively, due to bioluminescence) the properties of which, determined based on detection of such signal with an optical detector device, provide characterization of the stimulus and information required for user-defined activation of emitter cells encapsulated in the hydrogel.
The General Hospital Corporation
02/26/15
20150056141
new patent

Benzothiophene compound, alternative autophagy-inducing agent and anticancer agent including the compound as active ingredient, and screening for compound having anticancer activity


It has been found that efficient screening for a compound having anticancer activity can be achieved by selecting a compound having activity to induce alternative autophagy using, as an index, formation of fluorescent bright spots due to aggregation of a lysosomal protein to which a fluorescent protein is attached in cells expressing the lysosomal protein. In addition, it has been found that a benzothiophene compound represented by the following general formula (1) has alternative autophagy-inducing activity and anticancer activity:.
National University Corporation Tokyo Medical And Dental University
02/26/15
20150056137
new patent

Caspase-triggered nano-aggregation probes and methods of use


Provided is an activatable probe that undergoes intramolecular cyclization and subsequent aggregation in apoptotic tumor cells upon peptidase-initiated, and most advantageously caspase-3, activation. These caspase-sensitive nano-aggregation probes (c-snafs) are generally biocompatible, possess nir spectral properties or may serve as pet or mri imaging agents, and have a mechanism of target-mediated nanostructure self-assembly amenable to in vivo use.
The Board Of Trustees Of The Leland Stanford Junior University


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