|| List of recent Cells-related patents
|Recombinant dna constructs employing site-specific recombination|
Recombinant dna constructs, for use in plants and plant cells, have site-specific recombination sites that allow assessing phenotypes and modes of action by over expression or suppression of endogenous genes. In an aspect, a single dna construct can be switched between over expression and suppression by the action of a recombinase such as the cre recombinase on constructs having lox recombination sites.
|System and method for parallel processing using dynamically configurable proactive co-processing cells|
A parallel processing architecture includes a cpu, a task pool populated by the cpu, and a plurality of autonomous co-processing cells each having an agent configured to proactively interrogate the task pool to retrieve tasks appropriate for a particular so-processor. Each co-processor communicates with the task pool through a switching fabric, which facilitates connections for data transfer and arbitration between all system resources.
|Graphical marking to indicate edited data|
A method and system to indicate edited cells during an editing session are described. The method includes displaying a plurality of cells, of the plurality of cells being editable by a user.
|Configurable logic integrated circuit having a multidimensional structure of configurable elements|
An array processor composed of processor cells that are programmed by a controlling unit, and that are reprogrammed when a cell has finished a current data processing operation, even while other cell continue to process data with their current programming.. .
|Apparatuses and methods of operating for memory endurance|
Methods of operating an apparatus such as a computing system and/or memory device for memory endurance are provided. One example method can include receiving m digits of data having a first quantity of digits represented by a first data state that is more detrimental to memory cell wear than a second data state.
|Analyzing high dimensional single cell data using the t-distributed stochastic neighbor embedding algorithm|
A method for mapping, graphing, and analyzing high-dimensional single cell data based on multiple parameters associated with the cell, including defining a point associated with the cell in a n-dimensional space; combining the point with other points associated with other cells to form a data set; representing the points in the data set in the n-dimensional space; projecting the points in the n-dimensional space onto a lower-dimensional map; and analyzing the features of interest in heterogeneous tissues using the lower-dimensional map.. .
|Systems and methods for injecting cellular fluids|
A system includes at least one pressurizing mechanism, a fluid path adapted to be placed in operative connection with the pressurizing mechanism to deliver an injectate to a patient, wherein the injectate includes cells, a control system operably associated with the at least one pressurizing mechanism; and at least one parameter generation system in operative connection with the control system. The parameter generation system includes an input system to receive data of a type of cells to be injected and is adapted to generate at least one parameter for the injection procedure at least in part on the basis of the data of the type of cells.
|Method for obtaining sterile human amniotic fluid and uses thereof|
Provided herein is a pre-caesarean method for collecting amniotic fluid from a patient. A needle is inserted into the incision site for the future c-section, which may be under ultrasound guidance, through which the amniotic fluid is drawn under a low level suction and, optionally, gravity to a sterile collection container.
|Methods to regulate polarization and enhance function of cells|
Methods and compositions to controllably regulate cells at a target site. A quantum dot-targeting agent complex is administered to a patient in need of therapy, and the complex is stimulated using an implanted fiber optic system.
|Detection method of life activity, measuring device of life activity, transmission method of life activity detection signal, or service based on life activity information|
According to a measuring method or a control method of life activity, a life object is illuminated with an electromagnetic wave including a wavelength in a designated waveband, and a characteristic in a local area of the life object is detected, or a life activity thereof is controlled. The “designated waveband” is defined based on phenomena used for detecting or controlling an activity state of the life object or a change of the state.
|Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use|
This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
|Bioconjugate vaccines made in prokaryotic cells|
Provided herein are prokaryotic cells capable of producing bioconjugates comprising glycosylated proteins. Also provided herein are compositions comprising such bioconjugates and/or comprising the saccharide moieties of such bioconjugates, as well as methods of vaccinating subjects using such compositions..
|Monoclonal antibody against interferon-gamma (ifn-gamma) inducing factor (ifig, il-18)|
A protein which induces the ifn-γ production by immunocompetent cells and has a molecular weight of 19,000±5,000 daltons on sds-page or gel filtration method and a pi of 4.8±1.0 on chromatofocusing. The protein is isolated from mouse liver and can be purified by a monoclonal antibody specific to it.
|Avian derived antibodies|
The invention is drawn to a composition comprising an isolated mixture of cytotoxic anti-cd20 antibody molecules produces in a transgenic avian. The antibody molecules have a heavy chain and a light chain and exhibit an increased level of antibody-dependent cell-mediated cytotoxicity (adcc) as compared to that of anti-cd20 antibody molecules produced by cho cells..
|Methods and compositions for tumor vaccination and therapy|
The present invention relates to peptide vaccines, pharmaceutical compositions thereof, and associated methodologies that promote the immune-mediated regression of tumors expressing an onconeural antigen, e.g. A cdr-2 antigen, hud antigen.
|Molecular signatures of invasive cancer subpopulations|
Carcinomas typically invade as a cohesive multicellular unit, a process termed collective invasion. It remains unclear how different subpopulations of cancer cells contribute to this process.
|Srm/mrm assay for the ephrin typa-a receptor 2 protein|
Specific peptides, and derived ionization characteristics of the peptides, from the ephrin type-a receptor 2 (epha2) protein are provided that are particularly advantageous for quantifying the epha2 protein directly in biological samples that have been fixed in formalin by the method of selected reaction monitoring (srm) mass spectrometry, or what can also be termed as multiple reaction monitoring (mrm) mass spectrometry. Such biological samples are chemically preserved and fixed and are selected from tissues and cells treated with formaldehyde containing agents/fixatives including formalin-fixed tissue/cells, formalin-fixed/paraffin embedded (ffpe) tissue/cells, ffpe tissue blocks and cells from those blocks, and tissue culture cells that have been formalin fixed and or paraffin embedded.
|Therapeutic compositions and related methods of use|
Aqueous compositions comprising salinomycin, or a pharmaceutically acceptable salt thereof, miscible organic solvents, and solubilizers and/or emulsifying agents are disclosed. The formulations disclosed herein are useful in the treatment of cancer, especially cancers associated with cancer stem cells or cancerous mesenchymal cells.
|Virus vectors for highly efficient transgene delivery|
The invention provides viral vector formulations and methods of uses thereof for delivery of transgenes or therapeutic nucleic acids to human subjects. The formulations include a vector and suitable amounts of empty capsids, viral genome-containing capsids, or viral capsid proteins which are optionally chemically or structurally modified and which bind to neutralizing anti-aav antibodies thereby reducing or preventing antibody-mediated clearance of the vector, but still allowing the genome-containing (therapeutic) vector to transduce target cells and achieve therapeutic gene transfer..
|Methods and products for reawakening retrocyclins|
Products and methods are provided for the restoring the endogenous expression of theta-defensins, such as retrocyclin-1, in mamallian cells. The present invention also includes products and methods for inhibiting sexually transmitted virus entry, e.g., hiv-1 virus entry, into a mammalian cell via, for example, administering to a subject an amount of a read-through mediating agent sufficient to induce exogenous expression of an amount of retrocyclin nonapeptides in the mammalian cell..
|Compositions and methods for modulating myeloid derived suppressor cells|
Provided are methods and compositions for modulating the differentiation of a myeloid derived suppressor cell (mdsc). In particular, described herein are mir-142 polynucleotides and mir-223 polynucleotides that can be used to modulate differentiation of mdscs.
|Composition for preventing or treating obesity comprising rebamipide|
The present disclosure relates to a composition and a health functional food for preventing or treating obesity comprising a rebamipide compound or its pharmaceutically acceptable salt as an active component. It is confirmed that when a rebamipide compound of the present disclosure is administered to a mouse model induced with obesity, it shows excellent effects of reducing weight, reducing adipocyte, and reducing a total cholesterol content in the body, as compared with a non-administered control group, and also, it shows an excellent effect of suppressing differentiation of cytotoxic th17 cells that generate and secrets inflammatory cytokine and an excellent effect of improving activity of regulatory t cells (treg) capable of suppressing a function of abnormally activated immune cells and controlling an inflammatory reaction.
|Amine derivatives as potassium channel blockers|
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of kv1.3 channels found in t cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation..
|Potent non-urea inhibitors of soluble epoxide hydrolase|
The present invention relates to compounds that exhibit vasodilatory and anti-inflammatory effects by inhibiting the activity of soluble epoxide hydrolase (seh). The present invention is also directed to methods of identifying such compounds, and use of such compounds for the treatment of diseases related to dysfunction of vasodilation, inflammation, and/or endothelial cells.
|Benzopyran and benzoxepin pi3k inhibitor compounds and methods of use|
Benzopyran and benzoxepin compounds of formulas i and ii, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of pi3k, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of formulas i and ii for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed..
|Hemostatic agents and methods of use|
Modified chitosan hemostatic agents include reverse micelles (10) having an outer hydrophobic shell (12) of suitable biocompatible hydrophobic components such as alkanes, and hydrophilic positively charged chitosan moieties (14) enclosed within the hydrophobic shell (12). The hydrophobic shell (12) may be formed by attaching hydrophobic moieties to one end of chitosan polymer molecules while retaining sufficient reactive (positively charged) amine groups on the remainder of the chitosan polymers for effective blood clotting.
|Method for treatment of macular degeneration by modulating p2y12 or p2x7 receptors|
Provided is a method of treating or preventing age-related macular degeneration (amd) in a patient subject to, or symptomatic of the disease, wherein the method comprises restoring normal lysosomal ph (phl), or acidifying an abnormally elevated phl, thus decreasing or preventing a damaging accumulation of lipofuscin or waste products in the retinal pigment epithelium (rpe) cells of the eye of the patient. Further, this method is achieved by modulating the action of the p2x7 and/or p2y12 receptors of the rpe cells, specifically decreasing the acidity (phl) of the rpe lysosomes by administering selected receptor antagonists affecting the action of the p2x7 and/or p2y12 receptors of the rpe.
|Gigaxonin fusion protein and methods for treating giant axonal neuropathy|
The present disclosure relates generally to fusion proteins including gigaxonin coupled to a cell penetrant peptide. These fusion proteins can be used to treat gan in a subject in need thereof.
|Polypeptides targeting glycosylated muc2 proteins, methods of synthesis, their nucleic acids and uses thereof|
The invention relates to polypeptides, defined through a consensus sequence, having a length from 10 to 80 amino-acid residues, and whose polypeptidic sequence comprises or consists of the consensus sequence p1(xa)p3(xb)p5(xc)p6(xd)p7 (seq id no: 1), presenting specific patterns. The polypeptides of the invention target glycosylated muc2 proteins.
|Method and system for determinining whether genome is abnormal|
The present invention provides a method and system for determining whether a genomic abnormality exists. The method for determining whether a genomic abnormality exists includes the steps of: separating fetal nucleated red blood cells from a sample from a pregnant woman; sequencing at least a part of the genome of the nucleated red blood cells, so as to obtain a sequencing result; and on the basis of the sequencing result, determining whether a genomic abnormality exists in the nucleated red blood cells..
|Method for preparing improved cardiomycocyte-like cells|
The present invention relates to the field of cell differentiation. In particular, the present invention relates to a method for preparing improved cardiomyocyte-like cells differentiated from at least one multipotent or pluripotent cell, comprising a step of contacting the cardiomyocyte-like cell(s) with at least one agent to promote and/or induce integrin subunit alpha-v (integrin αv) activity, thereby modulating expression of at least one cardiac gene of said cardiomyocyte-like cells.
|Method of determination of cancer cell drug sensitivity towards aurora kinase inhibitors|
A method for determining the sensitivity and/or resistance of a patient suffering from a cancer disease to aurora kinase inhibitor therapy, which comprises determining in vitro in the cancer cells or body fluids taken from the patient the expression of at least one gene selected from a particular group and/or determining in vitro in the cancer cells or body fluids taken from the patient the level of at least one protein selected from a particular group.. .
|Devices, compositions, and methods for measuring molecules and forces|
This disclosure relates to compositions, devices and methods of detecting the presence of molecules and optionally quantifying forces associated with molecular interactions on the surface of cells and other lipids. In certain embodiments, devices disclosed herein can be used to detect forces through cell surface receptors.
|Detection of human somatic cell reprogramming|
The methods and kits described herein are based, in part, to the discovery of a phenotype representing a fully-reprogrammed ips cell and several reprogramming intermediates. The methods and kits described herein permit identification of fully-reprogrammed ips cells and further permits one of skill in the art to monitor the emergence of ips cells during the reprogramming process.
|Non-invasive early detection of solid organ transplant rejection by quantitative analysis of mixtures by deep sequencing of hla gene amplicons using next generation systems|
The invention is a method of detecting or assessing solid organ graft (transplant) rejection by detecting donor-specific hla alleles in a blood sample of a graft (transplant) recipient. The invention further comprises a method of detecting the presence of maternal cells in a blood sample of an offspring..
|Method and apparatus for controllably handing over a mobile terminal to a small cell within a heterogeneous network|
A method, apparatus and computer program product are provided for controlling the handover of a mobile terminal, particularly a quickly moving mobile terminal, to a small cell. In the method, the speed or the mobility state of the mobile terminal is determined.
|Method and ue for network attachment|
A method and a user equipment (ue) for network attachment are disclosed. The method includes receiving first status information associated with one or more remote radio units (rrus) for supporting the small cell from the one or more rrus, receiving second status information associated with one or more macro cells from one or more macro enbs for supporting the macro cell, selecting an rru and macro enb, which the ue wants to attach, among the one or rrus based on the first status information and the second status information, and simultaneously transmitting an attach request message for requesting network attachment from the selected rru and macro enb to the selected rru and macro enb..
|Cell search method for supporting discontinuous transmission and/or reception of base station|
Disclosed is a cell search method for supporting discontinuous transmission and reception of small cell base stations. A cell search method performed by a base station, in an environment that a plurality of small cell base stations perform discontinuous transmission and reception, may comprise transmitting information about small cell base stations whose current transmission and reception mode is in active state; receiving, from a terminal, measurement results on the small cell base stations included in the information about small cell base stations; estimating small cell base stations located around the terminal based on the measurement results; and transmitting, to the estimated small cell to stations, an instruction to change their transmission and reception modes.
|Cell search method|
A cell search method is disclosed. In an environment that a plurality of small cells are located around a macro cell, a macro base station may allocate a terminal-specific signal distinguishing a terminal from other terminal to the terminal which establishes a connection with the macro base station, and share information of the terminal-specific signal with a plurality of small cell base stations.
|Method and telecommunications network for deactivating or activating a cell in such a network|
The invention relates to a method for deactivation of at least one first cell of a plurality of cells in a telecommunications network. User devices in the at least one first cell are triggered to report measurement information regarding one or more second cells of the plurality of cells to the telecommunications network.
|Method and apparatus for determining serving sub-cell in wireless communication system including multiple sub-cell|
A method of determining a serving sub-cell of a terminal among a plurality of sub-cells by a base station in a wireless communication system is provided. The method includes generating reference signal transmission interval information for each of the sub-cells by configuring a reference signal transmission interval for each of the plurality of sub-cells, and transmitting the reference signal transmission interval information for each of the sub-cells to the corresponding sub-cell, receiving channel status information for at least one sub-cell among the plurality of sub-cells from the terminal, and determining a serving sub-cell of the terminal by using at least one of the reference signal transmission interval information, the channel status information, a reception time of the channel status information, of each of the sub-cells..
|Method and system for reducing co-channel interference due to the deployment of femtocells in a macro-cellular network|
During the optimisation step (3), the transmission powers of the femtocells are maximised under the constraint of maintaining a minimum quality of service of terminals that would be attached to the base stations in the macrocellular network.. .
|Manufacturing method of solid-state dye-sensitized solar cells and electrolyte filling device used therefor|
The present description is directed to a manufacturing method of solid-state dye-sensitized solar cells and a solid-state electrolyte filling device used in the manufacturing method. The present invention provides a manufacturing method of dye-sensitized solar cells that fills the solid-state electrolyte more uniformly with enhanced efficiency to secure higher light-to-energy conversion efficiency..
|Methods and compositions for generating sporulation deficient bacteria|
The present invention relates to methods and compositions for engineering sporulating bacterial cells, particularly a cell of the class clostridia. In particular, the present invention relates to the generation of sporulation deficient bacteria for the generation of industrial superior phenotypes..
|Human pluripotent stem cells produced by somatic cell nuclear transfer|
Human pluripotent embryonic stem cells produced by somatic cell nuclear transfer as well as methods of making and using said human pluripotent embryonic stem cells are disclosed.. .
|Defined systems for epithelial cell culture and use thereof|
The present invention provides cell culture media formulations which support the in vitro cultivation of animal epithelial cells. The media comprise at least one fibroblast growth factor (fgf) and at least one agent that induces increased intracellular camp levels, and optionally comprise ascorbic acid.
|Methods of using mechanical force with somatic and pluripotent cells|
Provided are methods useful in increasing efficiency of biotransport, reprogramming or altering a cell's state of differentiation, and maintenance of cells in an undifferentiated state.. .
|Method and devices for cryopreservation of biomaterials|
Improved methods for cryopreservation of cells result when cells are cooled at controlled rates in devices that ensure a constant rate of cooling of less than 10° c.. .
|Compositions and methods for promoting the generation of pdx1+ pancreatic cells|
Certain embodiments disclosed herein are directed to a method of producing pancreatic cells or pancreatic cell precursors by exposing human embryonic stem cells to an effective amount of at least one compound listed in table i to differentiate the human embryonic stem cells into the pancreatic cells or the pancreatic cell precursors. Kits and pancreatic cell lines produced using the methods are also described..
|Cell culture substrate, and method for manufacturing same|
A cell culture substrate is used comprising a photopolymerization initiator immobilized on a surface of the cell culture substrate, and a linear polymer immobilized on a part or the entirety of the surface via the photopolymerization initiator, and wherein the photopolymerization initiator is thioxanthone. Thereby, advantageously, a single type or multiple types of cells are efficiently cultured on specific regions of the culture substrate, and efficiently detached only by changing temperature on the surface of the substrate..
|Cell culture kit, and method of using cell culture kit|
A cell culture kit for cultivating cells in a closed system that comprises at least one or more of each of: a culture container for cultivating cells; a culture medium storage container for storing a culture medium or the like; a cell injection container for injecting cells; and a cell collecting container for collecting a suspension of cells after cultivation; wherein the culture medium storage container is also used as a waste liquid container for collecting a culture medium after cultivation, and the culture container, the culture medium storage container, the cell injection container and the cell collecting container are linked to one another through a conduit. Also provided is a cell culture kit including at least one or more of a sampling container that is capable of sampling part of a suspension of cells during cultivation, wherein the sampling container is linked to the culture container through a conduit..
|Methods and compositions relating to restricted expression lentiviral vectors and their applications|
The present invention provides hiv-derived lentivectors which are safe, highly efficient, and very potent for expressing transgenes for human gene therapy, especially, in human hematopoietic progenitor cells as well as in all other blood cell derivatives. The lentiviral vectors comprise promoters active to promote expression specific to cell types or tissues.
|Device for staining suspended cells|
A device for staining suspended cells composed of a cannula (1), a pushrod (2), a plunger sealing pad (3), and a capture membrane (4), wherein the plunger sealing pad (3) is located at an upper part within the cavity of the cannula (1), the capture membrane (4) is located at a lower part within the cavity of the cannula (1), and an opening (5) above the membrane and an opening (6) below the membrane are formed on the wall of the cannula (1) respectively. The device is for use in staining suspended cells, is capable of effectively overcoming the drawbacks in current existing methods for staining cells, such as high failure rates, low accuracy and repeatability, and being very time-consuming, etc., and has advantages such as high success rates, good accuracy and repeatability, and not being time-consuming, etc..
|Method for signal amplification in biosensor-based system for rapidly detecting infectious agents|
A system for detecting infectious agents in biological samples in real time that includes a sample to be tested for at least one specific infectious agent; and a biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested; and wherein the biosensor emits an amplified and detectable signal when it reacts with the specific infectious agent. Signal detection is enhanced through the release of lps from the cells of the infectious agent..
|Cell collection method|
A method for collecting cells that have been cultured by using a cell culture kit in which, at least, a culture container for cultivating cells, a cell collection container for collecting cells after cultivation and a waste liquid container for collecting a culture medium after cultivation are linked to one another through a conduit, the method including transferring a culture supernatant that has been cultured from the culture container to the waste liquid container, transferring a concentrated suspension of cells from the culture container to the cell collection container, returning part of the culture supernatant discharged in the waste liquid container to the culture container and allowing cells remaining in the culture container to be suspended in a suspension of cells, and transferring again a suspension of cells in which remaining cells are suspended from the culture container to the cell collection container.. .
|Reaction casing for a photosynthetic reactor and associated photosynthetic reactor|
Reaction casing (1) for a photosynthetic reactor suitable for cultivating photosynthetic microorganisms, in particular algae, said reaction casing (1) being designed for both floating on an expanse of water and defining a path for a gas/liquid culture medium to flow in two phases between a first and a second opening (11, 12) of said casing. The casing comprises, on the one hand, an upper membrane (31) and a lower membrane (32) made at least partially of a flexible material, hermetically sealed and transparent to light radiation, said membranes being hermetically connected to one another by connecting lines (41, 42) defining inflatable cells (33, 34) and, on the other hand, connection elbows (35, 36) joining said cells in pairs to define the course of flow in a generally sinuous form, one of the cells (33) being fluidly linked to the first opening and another cell (34) being fluidly linked to the second opening (12).
|Subtilase variants and polynucleotides encoding same|
The present invention relates to protease variants and methods for obtaining protease variants. The present invention also relates to polynucleotides encoding the variants; nucleic acid constructs, vectors, and host cells comprising the polynucleotides; and methods of using the variants..
|Increased production of secreted proteins by recombinant eukaryotic cells|
Described herein are methods for increasing the amount of protein secreted by a cell. In one case, a cell is provided which contains a heterologous nucleic acid encoding a protein having unfolded protein response modulating activity and a heterologous nucleic acid encoding a protein of interest to be secreted.
|Methods for promoting cell reprogramming|
The present invention is based on the seminal discovery that several kinases play important roles in barrier pathways in somatic cell reprogramming. The present invention provides that modulating expression or activity of these kinases can significantly promote or enhance cell reprogramming efficiency.
|Apparatus and process for production of an encapsulated cell product|
A process for production of an encapsulated cell product, the process comprises the steps of concentrating cells from a propagation medium using a tangential flow filtration system. Mixing the concentrated cells with an encapsulation medium to form a cell encapsulation mixture.
|Radiofrequency device for increasing intracellular bioactive substance and plant cell culture method using the same|
There are provided a radiofrequency device for increasing amount of a bioactive substance in a plant cell and a plant cell culture method for increasing amount of useful intracellular secondary metabolites by using the radiofrequency device. The cell culture method of the present invention makes it possible to increase specific secondary metabolites such as daidzein, equol, and the like in a cell and thus can be used for development into various medicines, agricultural pesticides, spices, pigments, food additives, and cosmetics containing bioactive substances.
|Desaturases and process for the production of polyunsaturated fatty acids in transgenic organisms|
The present invention relates to polynucleotides from cochliobolus heterostrophus c5, cyanothece sp. Ccy0110, mycocentrospora acerin and hyaloperonospora parasitica, which code for desaturases and which can be employed for the recombinant production of polyunsaturated fatty acids.
|Polypeptides having catalase activity and polynucleotides encoding same|
Provided are isolated polypeptides having catalase activity and polynucleotides encoding the polypeptides. Also provided are nucleic acid constructs, vectors and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
|Polypeptides having xylanase activity and polynucleotides encoding same|
The present invention relates to isolated polypeptides having xylanase activity and polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides..
|Lactonase derived from candida bombicola and uses thereof|
The present disclosure relates to an enzyme derived from candida bombicola that is capable of lactonizing or polymerizing carbohydrate-containing compounds, lipids, fatty acids, hydroxylated fatty acids, alcohols, dicarboxylic acids or mixtures thereof. Hence, host cells comprising the latter enzyme can be used, via the formation of intra- or inter-molecular ester-bounds, to produce, for example, lactonized sophorolipids or polymers of acidic sophorolipids.
|Il-17 binding proteins|
Proteins that bind il-17 and/or il-17f are described along with there use in composition and methods for treating, preventing, and diagnosing il-17 related diseases and for detecting il-17 in cells, tissues, samples, and compositions.. .
|Molecular characterization of circulating tumor cells|
The disclosed invention includes methods and kits for the removal of white blood cells from samples of enriched rare cells.. .
|Gender-specific identification of sperm cells and embryos using locked nucleic acids|
Disclosed are sperm cells and embryos comprising a labeled locked nucleic acid bound to a gender-specific repeat sequence. Methods for identifying and separating sperm cells or embryos containing a labeled locked nucleic acid from sperm cells or embryos not containing the labeled oligonucleotide produce gender-enriched sperm cell or embryo fractions.
|Enrichment & isolation of microbial cells & microbial nucleic acids from a biological sample|
A method for enrichment and isolation of microbial cells and microbial nucleic acids from a biological sample is described. The method comprises (i) adding to an initial volume of biological sample a differential cell lysis solution to obtain a final concentration of 0.1 to 1% of sds in the sample; (ii) mixing the solution obtained in step (i) for a period of time sufficient to lyse the host cells present in the biological sample, while preserving the integrity of cells; and (iii) separating the microbial cells from the lysed host cells components.
|Inducible cell-based model for the study of friedreich's ataxia|
Isolated transduced cells exhibiting frda characteristics in an inducible fashion are disclosed. Isolated transduced cells comprise an expression vector having a nucleic acid sequence encoding an shrna for frataxin protein knockdown and a heterologous expression control sequence.
|Human conducting airway model comprising multiple fluidic pathways|
A multicellular fluidic enhanced airway model system of the conducting airways as a tool for the evaluation of biological threats and medical countermeasures is provided. The airway model system can include a first chamber having an inlet and an outlet and containing epithelial cells; a second chamber having an inlet and an outlet and containing an extracellular matrix, wherein the second chamber is separated from the first chamber by a porous membrane; and a third chamber having an inlet and an outlet, wherein the third chamber is separated from the second chamber by a porous membrane, and wherein the airway tissue model system is configured to provide a separate fluidic pathway through each of said first, second, and third chambers.
|Method of teaching multiplication to mathematics students|
A method of teaching multiplication comprises the steps of providing a pair of multi-digit numbers to be multiplied and diagrammatically arranging the numbers on a work area. The work area includes a multiplication zone, an addition zone and an answer zone.
|Porous three-dimensional structure of polytetrafluoroethylene (versions), dental implant, vascular implant and tissue implant for substitution plasty of soft tissues|
A porous three-dimensional structure of polytetrafluoroethylene was created featuring an enhanced ability of soft tissue ingrowth, or, in the second embodiment, combining the properties of an enhanced ability of soft tissue ingrowth with a barrier for the deposition of the living tissue cells. In the first embodiment of the porous three-dimensional structure of polytetrafluoroethylene it contains the open through pores and the blind pores, uniformly distributed over the inner surfaces of the open pores and connected therewith, and is made of mixture of the free-flow polytetrafluoroethylene having the granules sized from 100 to 300 microns, and the constraint-flow polytetrafluoroethylene having the granules sized up to 20 microns.
|Alkaline battery with electrolyte gradient|
A membrane electrode assembly includes a gas diffusion layer, a catalytic layer in fluid communication with the gas diffusion layer, an anodic layer and a bipolar solid electrolyte disposed between the catalytic and anodic layers. The bipolar solid electrolyte inhibits carbonate formation in air breathing alkaline cells and inhibits dendritic growth between the anodic and catalytic layers..
|Electrode composition for a secondary battery cell|
Disclosed are a composite electrode material for a rechargeable battery; a method of making a composite electrode material; an electrode including the composite electrode material; cells including such electrodes; and devices including the cells. A composite electrode material for a rechargeable battery cell includes an electroactive material; and a polymeric binder including pendant carboxyl groups.
|Electrolytes for lithium sulfur cells|
Disclosed is an additive for an electrochemical cell wherein the additive includes an n—o bond. The additive is most preferably included in a nonaqueous electrolyte of the cell.
|Battery cell assembly of enhanced safety and battery module comprising the same|
Disclosed herein is a battery cell assembly including a plurality of battery cells stacked while being electrically connected to each other, wherein one or more of the battery cells are mounted in each cell housing member in a state in which opposite sides of the battery cells are surrounded by each cell housing member excluding electrode terminals of the battery cells, an expansion opening part, through which a portion of a main body of each of the battery cells is exposed outward when the battery cells expand, is formed at one surface or opposite surfaces of each of the at least two cell housing members and the battery cells are stacked such that the at least two expansion opening parts face each other.. .
|Bi-polar protected electrodes and multi-cell stacks|
Water activated alkali metal battery cells, protected anode bi-polar electrodes and multi-cell stacks are configurable to achieve very high energy density. The cells, bi-polar electrode and multi-cell stacks include a protected anode and a cathode having a solid phase electro-active component material that is reduced during cell discharge..
|Water-cooling type secondary battery|
Provided is a water-cooling type secondary battery, and more particularly, a water-cooling type secondary battery capable of improving heat conductivity to thereby increase cooling efficiency by integrally forming a refrigerant pipe on an edge part of heat radiating plates respectively interposed between a plurality of battery cells which are stacked in parallel with each other and closely adhered to each other.. .
|Bus bar modules|
A bus bar module may include a circuit side member associated with a battery assembly having a plurality of battery cells arranged next to each other in an arrangement direction, and a bus bar electrically connecting the circuit side member with the battery cells of the battery assembly. A gas discharge duct may be integrated with the circuit side member and configured to allow flow therethrough of gas discharged from safety valves associated with the battery cells..
|Bus bar modules|
A bus bar module may have a bus bar including a battery side terminal portion and a connection portion. The battery side terminal portion may electrically connect electrode terminals of two adjacent battery cells of a battery assembly.
|Method and device for extending the lifetime of a battery in particular of a vehicle|
A method includes coupling two conducting rods between terminals of a battery cell of a battery having several branches coupled in parallel, each branch having several battery cells coupled in series. A force tending to squeeze the rods against each other is applied, with the rods being held apart from each other using an insulating block.
|Thermal interface composite material and method|
A composite thermal interface material and methods are shown. Devices such as lithium ion batteries incorporating composite thermal interface materials show significant improvement in cooling performance.
|Membrane for use with implantable devices|
The present invention provides a biointerface membrane for use with an implantable device that interferes with the formation of a barrier cell layer including; a first domain distal to the implantable device wherein the first domain supports tissue attachment and interferes with barrier cell layer formation and a second domain proximal to the implantable device wherein the second domain is resistant to cellular attachment and is impermeable to cells. In addition, the present invention provides sensors including the biointerface membrane, implantable devices including these sensors or biointerface membranes, and methods of monitoring glucose levels in a host utilizing the analyte detection implantable device of the invention.
|Light directing films and methods of making same|
Light directing films have a surface comprising a plurality of microstructures with peaks extending along a length of the surface. Each microstructure includes a plurality of elevated portions and a plurality of non-elevated portions.
|3d fiber composite|
A composite having a core containing a cellular structure, reinforcing fibers, an upper face sheet, and a lower face sheet is provided. The cellular structure is a honeycomb structure containing strips of carrier material arranged in an x direction in an x-y plane, adhered together, and expanded in the x direction after adhesion.
|Tetrahydrocannabivarin (thcv) for use in the protection of pancreatic islet cells|
The present invention relates to the phytocannabinoid tetrahydrocannabivarin (thcv) for use in the protection of pancreatic islet cells. Preferably the pancreatic islet cells to be protected are beta cells.
|Materials and methods for treatment of disorders associated with oxidative stress|
The subject invention pertains to materials and methods for the prevention and treatment of disease conditions associated with oxidative stress or a compromised reducing environment, including inflammatory bowel diseases such as crohn's disease and ulcerative colitis. Therapeutic compositions of the invention include compositions that can neutralize hydrogen peroxide, such as reducing agents and oxidizing agents.
|Delivery of rna interfering agents|
Provided are compositions for the delivery of biomolecules, such as nucleic acids into target cells, and methods of making and using same. The compositions comprise nucleic acid delivery complexes that include a nucleic acid, such as an rna interfering agent, an rna neutralization domain, a double stranded rna binding domain, and a protein transduction domain..
|Methods and compositions for enhancing cd4+ regulatory t cells|
Disclosed are methods and related compositions for administering immunosuppressants and therapeutic macromolecules for enhancing cd4+ regulatory t cells.. .
|Nanoparticle-assisted ultrasound for cancer therapy|
Methods for killing cancer cells and treating cancer in a subject by exposing the cells to nanoparticles, and irradiating with a focused, low to medium power ultrasound. The nanoparticles can be gold, iron oxide, copper, silver, polystyrene, peg, or liposome nanoparticles.
|Wound-healing promoting material|
The object of the present invention is to provide a means for utilizing cells that have effects on wound healing as wound-healing promoting materials by efficiently concentrating such cells within a short period of time. The present invention provides a wound-healing promoting material which comprises a sheet-like porous body having on its surface at least leukocytes and/or platelets, a method for producing the same, a device for producing the same, and a method for treating wound sites using the same..
|Binding drugs with nanocrystalline cellulose (ncc)|
This invention describes nanocrystalline cellulose (ncc) for use as a drug delivery excipient. Ncc binds significant quantities of water soluble, ionizable drugs, e.g., tetratcycline and doxorubicin, which are released rapidly over a one day period.
|Suppressors of mature t cells|
Disclosed herein is a viral polypeptide and homologs thereof that inhibit an immune response, particularly the response of memory and effector cd4+ and cd8+ t cells.. .
|Utility of insulin-like 6 (insl6) for the treatment of autoimmune diseases|
The present invention is directed to compositions and methods to treat an autoimmune disease in a subject, comprising an insulin-like 6 (insl6) agent, such as an insl6 polypeptide or variant or fragment thereof, or a nucleic acid encoding insl6 poly peptide or variant or fragment thereof. Aspects of the present invention relate to use of insl6 agents to reduce t-regulatory (treg) cells in the subject and to reduce pro-inflammatory cytokines in a subject with an autoimmune disease such as a muscle autoimmune disease.
|Methods of generating hyper inos expressing cells and uses thereof|
A method of generating a hyper inos expressing cell includes administering to a myeloid derived cell an amount of a pparγ agonist and an il-6/stat3 signaling pathway antagonist effective to substantially inhibit stat3 activation in the cell and administering an inflammatory insult to the cell to stimulate hyper inos expression from the cell.. .
|Methods of detecting cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells|
The present invention relates to methods of modulating the uptake and/or clearance of cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof, which can be used to treat and/or prevent diseases such as cancer, autoimmunity and infections. The present invention also relates to methods of modulating antigen recognition, processing and/or presentation, as well as immune responses to material derived from cells with a disrupted cell membrane, cells infected with a pathogen, dying cells or dead cells, or a portion thereof.
|Cytokine receptors associated with myelogenous haematological proliferative disorders and uses thereof|
The disclosure relates to methods and compositions effective in the diagnosis, prognosis and treatment of human hematopoietic cancers. In particular, the disclosure provides tumor-associated genes that encode for cytokine receptors that are differentially expressed in hematopoietic tumor cells of myeloid origin compared with other cells, e.g., normal stem cells..
|Nanobodies against tumor necrosis factor-alpha|
The present invention relates to improved nanobodies™ against tumor necrosis factor-alpha (tnf-alpha), as well as to polypeptides comprising or essentially consisting of one or more of such nanobodies. The invention also relates to nucleic acids encoding such nanobodies and polypeptides; to methods for preparing such nanobodies and polypeptides; to host cells expressing or capable of expressing such nanobodies or polypeptides; to compositions comprising such nanobodies, polypeptides, nucleic acids or host cells; and to uses of such nanobodies, such polypeptides, such nucleic acids, such host cells or such compositions, in particular for prophylactic, therapeutic or diagnostic purposes, such as the prophylactic, therapeutic or diagnostic purposes..
|Method of isolating human antibodies|
Provided is a novel method of isolating and producing human antibodies with desired specificity from human b cells. In particular, a method of isolating human antibodies from memory b cells obtained from patients which suffer from a disease which is caused by or involves activation of the immune system, for example autoimmune and inflammatory disorders is described..
|Therapeutic agent for cancer, and method for determining prognosis of cancer|
Disclosed are a novel therapeutic agent for cancer such as esophageal squamous cell carcinoma, a method for predicting the prognosis of cancer, and a method for detecting, or predicting the prognosis of, cancer such as esophageal squamous cell carcinoma using a sample that can be collected less invasively. The therapeutic agent for cancer comprises as an effective component an antibody that undergoes antigen-antibody reaction with fgfrl1 to suppress the growth of cancer cells, or an antigen-binding fragment thereof.
|Modified heat shock protein-antigenic peptide complex|
The present invention relates to methods for purifying immunogenic, prophylactically and therapeutically effective complexes of modified heat shock proteins noncovalently associated with antigenic peptides of cancer or infected cells. The claimed methods comprise the constructing of a nucleotide sequence encoding a secretable modified heat shock protein, expressing the sequence in an appropriate host cell, recovering the immunogenic complexes from the cell culture and the cells, and purifying the immunogenic complexes by affinity chromatography.
|Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile|
A microorganism strain lactobacillus plantarum inducia dsm 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L.
|Co-cultured mesenchymal stem cells and myocytes|
Co-culturing of mesenchymal stem cells or tissues comprising mesenchymal stem cells with myocytes or myocyte containing tissues provide for the long term culture and expansion of myocytes. The co-culture gives rise to three-dimensional functioning cardiac tissue grafts or constructs..
|Equine amniotic membrane-derived mesenchymal stem cells|
The present invention relates to equine amniotic membrane-derived mesenchymal stem cells (eam-mscs) and a preparation method thereof. More specifically, the present invention relates to equine amniotic membrane-derived mesenchymal stem cells, which show negative immunological responses to all of the human markers cd19, cd20, cd28, cd31, cd34, cd38, cd41a, cd62l, cd62p and cd200, and positive immunological responses to all of the human markers cd44, cd90 and cd105, and have the ability to be maintained in an undifferentiated state for 14 passages or more and the ability to differentiate into ectoderm, mesoderm and endoderm-derived cells..
|Stem cell-derived neural cells for cell therapy in neurological disorders|
The present invention provides methods and uses of neural cells differentiated from adult stem cells of the oral mucosa for cell therapy of neurological and psychiatric diseases and disorders. Methods for direction of differentiation of oral mucosal stem cells into neuronal or neuron supporting cells are also provided..
|Assay for the prediction of therapeutic effectiveness of mesenchymal stromal cells, and methods of using same|
The invention relates to assays for testing the therapeutic effectiveness of mesenchymal stromal cell (msc) populations and methods of treating pathologies with passaged and/or frozen and thawed msc populations.. .
|Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging|
The present invention provides a pharmaceutical composition containing hemoglobin-based therapeutic agent for treating cancer. The hemoglobin moiety can target cancer cells and the therapeutic moiety (i.e.
|Method for preparing graphene|
The present invention relates to a method for preparing graphene substantially free of contamination by metallic, magnetic, organic and inorganic impurities, and also to the use of the resulting graphene for the production of transparent electrodes, batteries, electron-acceptor or electron-donor materials, in particular in photovoltaic systems, photovoltaic panels, transistor channels, in particular in electronics, nonlinear emitters or absorbers of infrared photons, current-conducting electrodes, anti-static coatings, chemical detectors, vias and interconnections in electronics, current-conducting cables, and solar cells.. .