|| List of recent Casein-related patents
|Nutritional composition comprising whey and hydrolyzed casein and uses thereof|
The present disclosure provides a nutritional composition, such as a preterm infant formula that includes a protein source comprising whey protein and hydrolyzed casein protein. The whey protein to hydrolyzed casein ratio may be from about 90:10 to about 50:50 by weight.
|Protein fortified yogurts and methods of making|
Methods of making protein-fortified yogurt products are described. The methods may include mixing a casein-containing ingredient with starting milk to make a yogurt milk, where the casein-containing ingredient has a casein-to-whey protein ratio of 82:18 or greater.
|Reduced calorie infant formulas containing specific whey to casein ratios|
The present disclosure is directed to nutrition systems including at least a first and a second reduced calorie infant formula having varying whey to casein protein weight ratios for reducing inflammation-related diseases later in life. Particularly, the nutrition systems may be administered to a newborn infant to reduce the risk of obesity later in life..
|Dietary product intended to reduce visceral fat during the pre-operative phase prior to bariatric surgery|
An orally administered dietary product intended to reduce an obese person's visceral fat during the pre-operative phase prior to bariatric surgery, the product includes in particular a mixture of: a whey hydrolysate having a molecular weight of between 200 and 10,000 daltons, an isolate and/or a concentrate of whey, and calcium caseinate.. .
|Protein seasonings and methods of making the same|
A protein seasoning and methods of making the same are provided. A formulation can be provided comprising a base combined with a protein source, which can be combined with various flavored seasonings/ingredients to form protein seasonings that can be added to different foods and/or liquids.
|Method for producing a milk product|
A method is disclosed for producing an infant formula base, wherein by means of microfiltration, ultrafiltration, and nanofiltration the components of milk are separated into a casein fraction, a whey protein fraction, and a lactose fraction to produce, by suitably combining, a composition in which the amino acid composition is close to that of human milk. An infant formula base having a total protein concentration of about 1.0 to about 1.5% and a β-casein concentration of at least about 11% of the total protein concentration is also disclosed.
|Dietary product intended for the prevention of cardiometabolic risk|
A dietary product for preventing cardiometabolic risk in humans, in particular for reducing visceral fat and deep subcutaneous fat, includes in particular a mixture of: a whey hydrolysate having a molecular weight of between 200 and 10,000 daltons, an isolate and/or concentrate of whey, and calcium caseinate.. .
|Methods for the bioremediation of petroleum in an aquatic environment|
In one embodiment, a bioremediation agent and method of bioremediation of an oil spill are disclosed. The bioremediation agent contains oil-digesting bacteria and bacterial nutrients in a buoyant water semi-insoluble and biodegradable casein product.
|Reducing the risk of autoimmune disease|
The present disclosure provides a method for reducing the risk of autoimmune disease by administering a composition comprising peptides selected from a casein hydrolysate. Such a composition, may reduce the symptoms of autoimmune disease and may be a treatment for autoimmune disease, especially type 1 diabetes.
|Crumble process cheese products and methods of production|
Crumble process cheese products may be produced by cooling process cheese to freezing temperatures below about 32° f. And holding the process cheese at the freezing temperatures for a sufficient amount of time to cause a freeze-induced denaturation of the protein bonds in the process cheese, thereby providing a modified process cheese with a texture adapted to crumble.
|Activating adiponectin by casein hydrolysate|
The present disclosure provides a method for activating adiponectin by administering a composition comprising peptides selected from a casein hydrolysate. Such a composition may reduce risk of heart attack and help in maintaining healthy weight.
|Reducing proinflammatory response|
The present disclosure provides a method for suppressing a proinflammatory response by administering a composition comprising peptides selected from a casein hydrolysate. Such a composition may reduce the levels of proinflammatory cytokines and may be a treatment for inflammatory disease, especially type 1 diabetes.
The invention relates to a dry compositions for lactic acid bacteria and in particular to a dry composition comprising from 109 to 1013 cfu/g of the composition of lactic acid bacteria cells, wherein the composition is characterized by that it also comprises following amounts of protective agents (all amounts of protective agents below are given relative to 1 g of lactic acid bacteria cells in the composition): from 6 to 9 g of trehalose, from 0.1 to 1 g of inulin and from 0.5 to 3 g of hydrolyzed casein, and by that it does not comprise a salt of alginic acid. The composition has an improved storage stability of the cell of interest.
|Continuous cheese production process|
Processes and equipment for continuously making a substitute or imitation cheese by feeding a heated first liquid stream including emulsifying salt, water and cheese powder into a cooker which is a twin screw mixer, feeding a heated second liquid stream including oil and casein or a non-dairy protein into the cooker, processing the first liquid stream and the second liquid stream through the cooker to form a cheese composition, and cooling the cheese composition. The cheese composition may be continuously extruded in a desired shape such as sheets or ropes and/or may be continuously cooled and cut into pieces having a reduced size such as a size to approximate shredded cheese..
|Dairy based compositions with low lps|
The present invention is directed to a method to produce a dairy based food composition with low lps comprising the steps (a) providing a milk with a storage time of less than 264 hours and either (b1) treating the milk with a microfilter of poresize of from 0.01-2 μm such that at least a casein rich fraction and a serum protein rich fraction is obtained, or (b2) treating the milk such that at least 98 wt % of the gram negative bacteria is removed, and heating the milk wherein at least 98wt % of the gram negative bacteria is removed to 60-90° c. The methods of the present invention are very suitable to provide a dairy based food composition wherein less than 5100 eu lps per liter ready to use food composition is present or wherein less than 39 eu lps per gram dry product is present..
|Sterilized liquid protein supplement|
Disclosed are sterilized liquid protein supplements including extensively hydrolyzed casein for use with human milk and other infant feeding formulas. The sterilized liquid protein supplements have a low ph, thereby inhibiting protein denaturation and reducing microbial growth..
|Exogenous opioid peptide-degrading enzyme|
The present invention is intended to provide a means for efficiently degrades exogenous opioid peptides. Provided is an exogenous opioid peptide-degrading enzyme preparation which contains one or more components selected from the group consisting of enzyme preparations from penicillium citrinum, aspergillus oryzae, and aspergilius melleus, and exhibits a degradation activity for a wheat gluten-derived opioid peptide and a casein-derived opioid peptide..
A casein hydrolysate formed by controlled hydrolysis of a casein substrate by an aspergillus-derived (fugal) proteolytic preparation is described. The controlled hydrolysis employs a flavorpro-whey™ formulation and a degree of hydrolysis (% dh) of from 5% dh to 15% dh.
|Composition containing s-adenosyl-l-methionine with excellent storage stability|
The present invention relates to a composition including s-adenosyl-l-methionine; and at least one kind of additive selected from carboxymethylcellulose, hydroxypropylcellulose, soybean polysaccharide, casein sodium, and zein, in which s-adenosyl-l-methionine is extracted from s-adenosyl-l-methionine-containing cells obtained by culturing a microorganism having an ability to produce same, and the content of the additive in the composition falls within the range of 0.05 to 15 times by mass of s-adenosyl-l-methionine in the composition. The present invention provides a composition containing a high concentration of s-adenosyl-l-methionine, which is useful as a water-soluble physiologically active substance, and being excellent in storage stability and bioabsorbability.
|Methods for the remediation of algal blooms|
In one embodiment, a remediation agent and method of remediation of an algae bloom are disclosed. The remediation agent contains light absorbing compounds in a buoyant water semi-insoluble and biodegradable casein product.
|Composition with improved digestibility of proteins|
The present invention relates to method to produce a dairy based food composition comprising protein comprising the steps (a) treating the milk such that at least 98% of the pathogens is removed, (b) treating the milk with a microfilter of a poresize of 0.01-2 micron such that at least a casein rich fraction and a serum protein rich fraction is obtained, wherein the milk is subjected to a heating treatment before or after the microfiltration and wherein during the production the milk and products obtained from the milk are not subjected to a heat treatment at a temperature above 90° c., and wherein the serum protein rich fraction and/or the casein rich fraction is processed into a food product. The invention also is directed to products made by the process..
|Compositions and methods for augmenting kidney function|
A protein-rich nutritional food product composed of a probiotic and an edible isolated protein. The probiotic component may comprise lactobacillus, bacillus, streptococcus bifidobacteria, saccharomyces or leuconostoc.
|Enteric delivery of functional ingredients suitable for hot comestible applications|
A microencapsulated enteric matrix composition and method for manufacture are provided. The microencapsulated enteric composition includes enteric material, such as sodium caseinate and soy protein, and a functional ingredient contained therein in a core.
|Method of producing a composition containing caseino-macropeptide|
The present invention pertains to a method of producing caseinomacropeptide (cmp)-containing compositions in high yield and having a very low content of phenylalanine (phe). More specifically, the method involves subjecting a whey derived feed to a combination of ultrafiltration and subsequent cation exchange..
|Use of a nucleotide for improving the heat stability of an aqueous micellar casein composition|
The invention relates to the use of one or more nucleotides for improving the heat stability of an aqueous micellar casein composition comprising 6 to 20 g per 100 ml of micellar casein, and having a ph of about 6 to 8. The invention also relates to heat-treated liquid nutritional compositions comprising 6 to 20 g, preferably 9-20 g, of protein per 100 ml of the composition and having a ph of about 6 to 8, in which all or a major part of said protein comprises micellar casein, further comprising one or more nucleotides..
|Composites containing polypeptides attached to polysaccharides and molecules|
This document provides methods and materials related to composites or coatings containing polypeptides attached to polysaccharides and/or molecules. For example, methods and materials related to composites or coatings containing polypeptides (e.g., casein polypeptides) attached to polysaccharides (e.g., cellulose) and/or molecules (e.g., calcium containing molecules such as calcium phosphate and calcium carbonate and/or polyesters such as polylactic acid and polyhydroxybutyrate) are provided.
|Aminopyrimidine kinase inhibitors|
Disclosed are compounds, pharmaceutical compositions containing those compounds, and uses of the compounds and compositions as modulators of casein kinase 1 (e.g., ck1γ), casein kinase 2 (ck2), pim1, pim2, pim3, the tgfβ pathway, the wnt pathway, the jak/stat pathway, and/or the mtor pathway. Uses are also disclosed for the treatment or prevention of a range of therapeutic indications due at least in part to aberrant physiological activity of casein kinase 1 (e.g., ck1γ), casein kinase 2 (ck2), pim1, pim2, pim3, the tgfβ pathway, the wnt pathway, the jak/stat pathway, and/or the mtor pathway..
|Reduced sodium food products formed of potassium-containing emulsifying salt mixtures and methods of making and using same|
A method of preparing a less sodium food product involves forming a reaction mixture of one or more of liquid sodium potassium hydrogen phosphate and liquid sodium dipotassium phosphate and combining a food ingredient with the emulsifying salt mixture. A reduced sodium process cheese product is formed of a sol to gel conversion fat stabilized via a hydrated protein matrix by a combination of potassium caseinate and sodium caseinate in which the caseinates are derived from an emulsifying salt mixture of liquid sodium potassium hydrogen phosphate and liquid sodium dipotassium phosphate, which, prior to reaction, accounts for at least about 2.5 and up to about 8.32 percent by weight of a total weight of the process cheese product.
|Method of making a milk protein composition|
Described is a method of of providing milk proteins from raw animal milk. The method comprises subjecting the milk to two microfiltration steps.
|Method for isolating osteopontin using feeds containing cmp or casein species|
The present invention pertains to a method for isolating osteopontin from a milk-derived feed containing caseino macropeptide and/or free beta casein, such as e.g. A feed based on milk serum or sweet whey.
|Compositions and methods for improving curd yield of coagulated milk products|
Disclosed are compositions and methods for enhancing the yield of coagulated milk products including cheese and other fermented milk products. Admixture of structurally expanded celluloses into milk allows substantial incorporation of additional whey solids and fluids into the caseinate matrix.
|Age-tailored nutrition system for infants|
The invention relates to the use of a protein source comprising whey and casein proteins for providing an age-tailored nutrition system to an infant which system comprises two infant formulas each appropriate to an infant of a different age and each comprising the protein source wherein the whey casein ratio of each formula is chosen in the range from 100:0 to 40:60 and decreases according to the age of the infant and the protein content of each formula is chosen in the range from 1.5 to 3.0g protein/100 kcal and decreases according to the age of the infant.. .
|Age-tailored nutrition system for infants|
The invention relates to the use of a protein source comprising whey and casein proteins for providing an age-tailored nutrition system to an infant which system comprises two infant formulas each appropriate to an infant of a different age and each comprising the protein source wherein the whey casein ratio of each formula is chosen in the range from 100:0 to 40:60 and decreases according to the age of the infant and the protein content of each formula is chosen in the range from 1.5 to 3.0 g protein/100 kcal and decreases according to the age of the infant.. .
|Methods and compositions of camel derived products|
The present invention provides a composition, a dairy product, and a method for treating a disorder in a subject. The composition includes (i) polymeric nanoparticles and (ii) camel derived glycosaminoglycans (gag)s ionic complex encapsulated into the nanoparticles, at least one active ingredient encapsulated into the nanoparticles, or combinations thereof.
|Casein kinase 1delta (ck 1delta) inhibitors and their use in the treatment of neurode-generative diseases such as tauopathies|
The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (ck1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as alzheimer's disease.. .
|Pre-thickened compact liquid nutritional composition for dysphagia patients|
The invention pertains to a liquid enteral nutritional composition with an energy density between 1.0 and 4.0 kcal/ml, a viscosity between 150 and 1800 mpas measured at a shear rate of 50/second at 20° c., comprising digestible carbohydrates and fat, wherein the composition further comprises at least one of (a1)) between 8-20 g protein per 100 ml of the composition, where micellar casein comprises at least 50 wt % of the total protein content of the composition, or (a2) between 16-45 en % protein, where micellar casein comprises at least 50% of the protein caloric content; and (b) anionic fibers capable of sequestering of calcium, and (c) carrageenan between 0.015 and 0.25 g per 100 ml of the composition, and its use for preventing/treating dysphagia, and/or treating/preventing malnourishment or undernourishment associated with dysphagia.. .
|High energy liquid enteral nutritional composition|
High energy and high protein liquid nutrition enteral compositions are provided that contain micellar casein and caseinate, an optionally a small amount of whey.. .
|Casein kinase 1delta (ck 1delta) inhibitors|
The invention relates to pharmaceutical compositions comprising casein kinase 1 delta (ck1δ) and to the use of said inhibitors in the treatment of neurodegenerative disorders such as alzheimer's disease.. .
|Cheese and preparing the same|
The invention relates to a method for producing cheese, comprising the steps of: providing a milk raw material, subjecting the milk raw material to microfiltration and pre-acidification to produce an acidified casein concentrate, where the microfiltration is performed prior to orsimultaneously with the pre-acidification, concentrating the acidified casein concentrate to produce full concentrated pre-cheese, processing the full concentrated pre-cheese to a cheese product. The invention also relates to cheese having a ratio of total content of β-lactoglobulin and α-lactalbumin to glycomacropeptide of at most about 1.35..
|Milk-based product and a method for its preparation|
The invention relates to a whey protein product having a ratio of whey protein to casein in the range from about 25:75 to about less than 50:50, a total protein content of at least 20% on dry matter basis, and a protein content of about 2.5 to about 8% by weight, based on the weight of the product. The product has a favourable amino acid composition and is especially suitable for athletes.
|Protein beverage and method of making same|
A protein beverage composition and a method of making it relate to a beverage including a protein essentially free of caseinate and derived from an aqueous protein isolate collected from membrane-filtration isolation of the protein and without substantial drying, wherein the protein beverage composition exhibits a ph ranging from about 2.0 to about 4.6. Substantial solubility of the protein is maintained in the beverage composition, and the protein beverage is essentially free of active microbes known to be harmful to human health, both at the time of packaging of the protein beverage and for a time period of at least one year after packaging..
|Method for using an enzyme resistant to high pressures|
At least at least one embodiment of the present invention relates to a method for using a high pressure-resistant enzyme in a high pressure condition; a method for promoting the activity of the high pressure-resistant enzyme by means of a high pressure treatment; a composition, which contains the high pressure-resistant enzyme, for decomposing proteins under a high pressure condition; a composition, which contains the composition for decomposing proteins, for preparing natural flavoring substances; a container for high pressure treatment, which contains the composition for decomposing proteins; and a method for measuring the activity of the high pressure-resistant enzyme, which comprises a step of decomposing an azocasein solution serving as a substrate by using the high pressure-resistant enzyme treated under a high pressure condition.. .
|Milk protein concentrates|
A method for making a milk protein concentrate can comprise heating a liquid milk composition at near its natural ph to a temperature that causes the whey protein in the milk to bind to the casein in the milk to form protein aggregates. After cooling, the liquid milk composition can be subjected to membrane filtration using a membrane filter having a large pore size.
|Multivalent breast cancer vaccine|
Compositions and methods for immunization against human breast cancer are disclosed. In one embodiment the multivalent antigenic composition is provided comprising immunogenic polypeptides selected from the group consisting of human α-lactalbumin, αs1 casein, β-casein and κ-casein..
|Isolation, cloning, sequencing and functional analysis of ß-casein promoter along with the regions of exon1, intron1 and exon2 using mammary gland derived cell line of buffalo (bubulus bubalis)|
The present invention relates to a method of in vitro isolation of buffalo β-caesin promoter (bucsn2) along with the regions exon1, intron1 and exon2 from the genomic dna in vitro (bubalus bubalis) and its functional activity in using mammary cell line. The novel buffalo β-caesin promoter along with exon1, intron1 and exon2 is isolated and cloned upstream of the enhanced green flourescence protein (egfp) gene and sequenced.
|Coffee whitener, process for producing same, and process for producing beverage|
Coffee whiteners prepared by using, as the aqueous phase thereof, a casein-containing milk protein solution that has been deamidated with a protein deamidating enzyme, exhibit excellent storage stability and dispersibility in coffee without the use of synthetic emulsifiers.. .
|Methods for making milk-like beverages|
The invention provides methods for making a milk-like beverage compositions comprising creating a homogeneous aqueous mixture of (1) one or more caseinates, (2) whey protein, (3) one or more fats, (4) one or more hydrocolloids, and (5) one or more emulsifiers; heating the aqueous mixture to a temperature of from about 118 to about 127° c. And maintaining such temperature for from about 8 to about 14 minutes; and cooling the heated aqueous mixture to a temperature of from about 20 to about 35° c.
|"nanoparticles for the encapsulation of compounds, preparation thereof and use of same"|
The present invention relates to nanoparticles for encapsulating compounds, the preparation and uses thereof, comprising a casein matrix, a basic amino acid and a metal selected from a divalent metal, a trivalent metal and combinations thereof. Said nanoparticles can encapsulate a water soluble or fat soluble biologically active compound.
|Method for producing gardenia blue pigment|
Provided is a method for producing a gardenia blue pigment resistant to discoloration which may occur in colored sugar-coated food or pharmaceutical products. The method for producing such a gardenia blue pigment comprises performing membrane separation using a membrane (for example, an ultrafiltration membrane) with a molecular weight cut-off of 3000 da or larger for removal of low-molecular compounds from a solution resulting from β-glucosidase treatment of an iridoid glycoside (for example, geniposide etc.) in the presence of a protein hydrolysate (for example, a casein protein hydrolysate), the iridoid glycoside being obtainable by extraction from fruits of gardenia jasminoides (rubiaceae).
|Derivatives of 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo[1,2-b]-pyridazine and 6-cycloamino-2-furanyl-3-(pyridin-4-yl)imidazo[1,2-b]-pyridazine, preparation and therapeutic use thereof|
The invention relates to derivatives of 6-cycloamino-2-thienyl-3-(pyridin-4-yl)imidazo[1,2-b]-pyridazine and 6-cycloamino-2-furanyl-3-(pyridin-4-yl)imidazo[1,2-b]-pyridazine with general formula (i). The invention also relates to a method for the preparation and therapeutic application thereof, in the treatment or prevention of illnesses involving casein kinase 1 epsilon and/or casein kinase 1 delta..
|Method for detecting adrenocorticotropic hormone and adsorbent|
A method for detecting adrenocorticotropic hormone comprising: bringing a liquid sample containing adrenocorticotropic hormone into contact with gelled casein to adsorb adrenocorticotropic hormone to the gelled casein; and detecting the adrenocorticotropic hormone adsorbed to the gelled casein is disclosed. An adsorbent of adrenocorticotropic hormone comprising gelled casein is also disclosed..
|Foam molding shell for a centrifuge bowl, centrifuge bowl, method for producing a thermal insulation encaseing a bowl of a centrifuge and centrifuge|
A foam molding shell for a centrifuge bowl, a bowl for a centrifuge, a method for producing a thermal insulation encasing the bowl for the centrifuge and to a centrifuge. The foam molding shell is configured as a disposable tool for foam encasing the bowl for the centrifuge with the thermal insulating material.
|Stable high lipid liquid formula|
The present invention provides a ketogenic diet in the form of a sterile shelf stable ready to use formula, in particular a tube feed, comprising casein and dietary fibre.. .
|Inhibitor of casein kinase 1delta and casein kinase 1e|
Wherein x represents a halogen atom (which may be any one of a fluorine atom, a chlorine atom, a bromine atom, and an iodine atom).. .
|Immunochromatography reagent composition, and measurement method using same|
When an immunochromatography reagent composition containing a nonionic surfactant, an n,n-bis(2-hydroxyethyl)glycine buffer, and casein is used as a specimen treatment solution or developing solution in detecting a detection object in a specimen according to an immunochromatographic method, an immunochromatography reagent composition which suppresses a non-specific reaction; does not cause aggregation of antibody-immobilized colloidal gold; and has a high developing rate, in comparison with conventional technology which detects a detection object by using an immunochromatographic device; and a high-performance and highly-sensitivity immunochromatographic method and a detection kit capable of rapid, simple and easy virus detection, which use the immunochromatography reagent composition are provided.. .
|Frozen confectionery products with improved texture|
The present invention relates to a method for producing frozen confectionery products. In particular, the invention is concerned with a method which contributes to the improvement of textural and sensorial attributes of the confections obtained thereof, in particular of products based on lower fat formulations.
|Dosing protocols for increasing protein synthesis in an active individual|
Methods utilizing either bite-size nutritional products or large individual protein doses for customized protein intake are provided. In a general embodiment, the present disclosure provides a method of providing nutrition to an athlete.
|Compositions and methods for increasing poultry hatchability and early performance|
Compositions and methods of improving poultry hatch health are provided herein. Poultry hatch health and hatchability may be improved by administering compositions in ovo prior to hatch.
|Methods for identifying and using inhibitors of casein kinase 1 epsilon isoform for inhibiting the growth and/or proliferation of myc-driven tumor cells|
In one aspect, the invention provides a method for inhibiting the growth and/or proliferation of a myc-driven tumor cell comprising the step of contacting the tumor cells with a csnk1ε inhibitor. In another aspect, the invention provides a method of treating a subject suffering from a tumor comprising myc-driven tumor cells, comprising administering to the subject an amount of a composition comprising a csnk1ε inhibitor effective to inhibit the growth and/or proliferation of the tumor cells..
|Casein peptide for use in the treatment of uterine infections|
The present disclosure relates to a casein peptide for use in the treatment of an uterine infection in a female mammalian animal, to methods of treatment of such infections by administering to a female mammalian animal at least one casein peptide, to the use of casein peptide for the preparation of a pharmaceutical composition for treatment of uterine infection and to a kit for said treatment. The casein peptide is preferably a casein hydrolysate, e.g.
|Iron (iii) caseinsuccinylate and method for the preparation thereof|
The present invention further refers to a method for preparing iron (iii) caseinsuccinylate.. .