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Cardiovascular patents

      

This page is updated frequently with new Cardiovascular-related patent applications.




 Heterocyclyl-butanamide derivatives patent thumbnailHeterocyclyl-butanamide derivatives
In which w, x and y have the meanings indicated in claim 1, are inhibitors of tankyrase, and can be employed, inter alia, for the treatment of diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of inflammation.. .

 Heteroaryls and uses thereof patent thumbnailHeteroaryls and uses thereof
And pharmaceutically acceptable salts thereof, wherein x, r1, r2, r3, r4, r5, l1, l2, m, and n, are as described in the specification. Such compounds are inhibitors of vps34 and thus useful for treating proliferative, inflammatory, or cardiovascular disorders..

 Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds patent thumbnailBeta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
Disclosed are beta and gamma-amino isoquinoline amide compounds and substituted benzamide compounds. In particular, the invention provides compounds that affect the function of kinases in a cell and that are useful as therapeutic agents or with therapeutic agents.
Aerie Pharmaceuticals, Inc.


 Cycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses patent thumbnailCycloalkyl-hydroxyl compounds and compositions for cholesterol management and related uses
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, alzheimer's disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, syndrome x, thrombotic disorder. Compounds and methods of the invention can also be used to modulate c reactive protein or enhance bile production in a patient.
Esperion Therapeutics, Inc.


 Co-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders patent thumbnailCo-therapy comprising canagliflozin and phentermine for the treatment of obesity and obesity related disorders
The present invention is directed to the use of co-therapy comprising administration of canagliflozin and phentermine for the treatment of obesity and obesity related disorders. More particularly, the present invention is directed to co-therapy for treating obesity, for promoting weight loss and/or for suppressing appetite; for treating, delaying, slowing the progression of and/or preventing metabolic disorders (including for example type 2 diabetes mellitus); for treating, delaying, slowing the progression of and/or preventing renal or fatty liver disorders (including for example nash, nafld, etc.); for treating, delaying, slowing the progression of and/or preventing sleep disorders (including for example sleep apnea); for providing cardiovascular protection; for treating, delaying, slowing the progression of and/or preventing cardiovascular events (including major adverse cardiac events (mace) such as myocardial infarction, unstable angina, cardiovascular death, revascularization, fatal or non-fatal cerebrovascular accident, peripheral arteriopathy, aortic events, hospitalization due to congestive heart failure, etc.); and/or for extending or prolonging life span..
Janssen Pharmaceutica Nv


 Perfusion balloon designs patent thumbnailPerfusion balloon designs
Disclosed herein are designs for improved inflatable structures for use during minimally invasive cardiovascular procedures. These inflatable structures facilitate the perfusion of blood through an anatomical structure, such as a heart valve, during the cardiovascular procedure.
Edwards Lifesciences Corporation


 Electronic catheter stethoscope patent thumbnailElectronic catheter stethoscope
An electronic catheter stethoscope measures and analyzes acoustic fields and dynamic pressure variations in the gaseous or liquid fluid inside a conventional medical catheter that is positioned in a patient's urologic, digestive, reproductive, cardiovascular, neurological or pulmonary system. Measurement transducers are installed in a housing connectable to multiple preselected medical catheters.
The Charles Stark Draper Laboratory, Inc.


 System and  blood pressure measurement, computer program product using the method, and computer-readable recording medium thereof patent thumbnailSystem and blood pressure measurement, computer program product using the method, and computer-readable recording medium thereof
The present invention provides a system and method for blood pressure measurement, a computer program product using the method, and a computer-readable recording medium thereof. The present invention uses a sensor to measure an electrophysiological signal and establishes a personalized cardiovascular model through a numerical method, and re-establishes the personalized cardiovascular model through an optimization algorithm.
National Chiao Tung University


 Cd82-positive cardiac progenitor cells patent thumbnailCd82-positive cardiac progenitor cells
An object of the present invention is to provide a myocardial progenitor cell that is specifically induced to differentiate into a cardiomyocyte, and a method for preparing the myocardial progenitor cell. A method for preparing a cd82-positive cell includes, in sequence, a step (a) of obtaining stem cells, a step (b) of subjecting the stem cells to induction treatment of differentiation into cardiovascular cells, and a step (c) of separating, from the stem cells having been subjected to the induction treatment of differentiation in the step (b), a cd82-positive cell being negative for at least one cell surface marker selected from cd73, cd44, cd105, cd121a, cd18, and cd120a.
Iheart Japan Corporation


 Agents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 h)-quinolone patent thumbnailAgents for use in the treatment of cardiovascular and inflammatory diseases structurally based on 4(1 h)-quinolone
Said aryl, heteroaryl, cycloalkyl and heterocyclyl groups being unsubstituted or substituted with one or more substituents selected from halogen, hydroxy, c1-c4 alkyl, c1-c4 hydroxyalkyl, c1-c4 alkoxy, c1-c4 haloalkyl, c1-c4 haloalkoxy, —sor, —so2r, —nr′r″, —nr′(c═o)r″, —coor, nitro and cyano substituents, wherein r, r′ and r″ are the same or different and each represents a hydrogen atom or c1-c4 alkyl group.. .

Lactococcus lactis strains

New lactococcus lactis strains, nrrl b-50571 and nrrl b-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower ldl-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation..
Centro De Investigación En Alimentación Y Desarrollo, A.c. (ciad)

Lactococcus lactis strains

New lactococcus lactis strains, nrrl b-50571 and nrrl b-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower ldl-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation..
Centro De Investigación En Alimentacion Y Desarrollo, A.c. (ciad)

Method and system for acquiring data for assessment of cardiovascular disease

A method and system for acquiring data for assessment of cardiovascular disease, the method comprising one or more of: manipulating one or more hardware aspects of the photoplethysmography data acquisition system(s) implementing the method; manipulating or providing user experience/user interface (ux/ui) aspects of the system(s) implementing the method; acquiring, processing, and deriving insights population specific data; accounting for or controlling sampling site variability; and using other suitable sources of data in order to generate high quality data for characterization, assessment, and management of cardiovascular disease.. .
Vital Labs, Inc.

Cardiovascular detection system and method

The detection and diagnosis of a variety of cardiovascular disorders and levels of heart condition, using a novel method and system, according to a comprehensive analysis of cardiac electrical signal via the frequency domain, time domain, spatial domain.. .

Heart rate playback machine

Improvements in a heart rate playback machine to initially monitor heart rate of a person performs cardiovascular exercise. The heart rate is generally monitored by a chest strap that is placed around the chest of a user that transmits either the beats or the calculated heart rate.
Paradigm Health And Wellness

High throughput biochemical fluorometric measuring hdl redox activity

In various embodiments, a new, robust fluorometric cell-free biochemical assay that measures hdl redox activity (hra) is provided. In certain embodiments the assay is based on the oxidation of the fluorochrome amplex® red in the presence of hrp.
The Regents Of The University Of California

Aplnr modulators and uses thereof

The present invention provides apelin receptor (aplnr) modulators that bind to aplnr and methods of using the same. The invention includes aplnr modulators such as antibodies, or antigen-binding fragments thereof, that inhibit or attenuate aplnr-mediated signaling.
Regeneron Pharmaceuticals, Inc.

Substituted [1,2,4]triazolo[1,5-a]pyrimidin-7-yl compounds as pde2 inhibitors

The invention provides a chemical entity of formula (i) wherein r1, r2, x, y and z have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods as disclosed herein, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive treatments; modulating and treating disorders mediated by pde2 activity; treating neurological disorders, cns disorders, dementia, neurodegenerative diseases, and trauma-dependent losses of function; treating stroke, including cognitive and motor deficits during stroke rehabilitation; facilitating neuroprotection and neurorecovery; enhancing the efficiency of cognitive and motor training, including animal skill training protocols; and treating peripheral disorders, including hematological, cardiovascular, gastroenterological, and dermatological disorders.. .
Dart Neuroscience (cayman) Ltd.

Enantiomers of the n-(2-amino-5-fluoro-2-methylpentyl)-8-[(2,6-difluorobenzyl)oxy]-2-methylimidazo[1,2-a]pyridine-3-carboxamide, as well as of the di- and trifluoro derivatives for the treatment of cardiovascular diseases

The present application relates to novel 6-hydrogen-substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft

Substituted imidazo[1,2-a]pyridinecarboxamides and their use

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft

Thromboxane receptor antagonists

The invention generally relates to compounds that function as tp antagonists for treating thrombosis and other cardiovascular, renal, or pulmonary diseases. In some embodiments, the invention provides a compound including a substituted nitro phenoxy phenyl, a sulfonylurea, and an alkyl group.
University College Dublin, National University Of Ireland, Dublin

Personalized creation from medical imaging

In personalized object creation, for implants, medical imaging is used to derive a model personalized to a patient. The model may be of a dynamic structure, such as part of the cardiovascular system, and is used to print the implant itself.
Siemens Medical Solutions Usa, Inc.

Steerable, conformable, drug eluting balloon catheter

A steerable, conformable, drug eluting balloon catheter device may comprise a catheter stem with one or more balloon element(s), themselves comprised of one or more segment(s) arranged radially or axially along the length of the device, and may allow precise deployment of vascular interventional devices, including coring devices and/or placement of stents, and may also allow targeted, specific placement of selected diagnostic or therapeutic materials on the walls of a vascular structure during a cardiovascular intervention procedure.. .
Transmed7, Llc

Methods of reducing the risk of a cardiovascular event in a subject on statin therapy

In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dl to about 500 mg/dl, and administering to the subject a pharmaceutical composition comprising about 1 g to about 4 g of eicosapentaenoic acid ethyl ester or a derivative thereof.. .
Amarin Pharmaceuticals Ireland Limited

Controlled balloon deployment

The methods and devices disclosed herein promote temporal control of balloon inflation patterns. The devices include a covering for a portion of the balloon that compresses the balloon portion during the inflation process.
Edwards Lifesciences Corporation

Non-invasive cardiovascular monitoring device

A cardiovascular monitoring system includes a sensor assembly and a controller. The sensor assembly includes a membrane enclosing a viscous fluid, a substrate immersed in the viscous fluid, and at least one strain gauge mounted with the substrate.

Method and system for image processing and patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data.
Heartflow, Inc.

Imidazo[1,2-a]pyridines as stimulators of soluble guanylate cyclase for treating cardiovascular diseases

The present application relates to novel heterocyclyl- and heteroaryl-substituted imidazo[1,2-a]pyridines, to processes for preparation thereof, to the use thereof, alone or in combinations, for the treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft

Imidazo[1,2-a]pyridines as soluble guanylate cyclase stimulators for the treatment of cardiovascular diseases

The present application relates to novel substituted imidazo[1,2-a]pyridine-3-carboxamides, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.. .
Bayer Pharma Aktiengesellschaft

Process for the synthesis of dabigatran etexilate and its intermediates

The present invention describes an improved process for the preparation of dabigatran etexilate (formula-vii) or it's pharmaceutically acceptable salt for the treatment of thrombosis, cardiovascular diseases etc. And intermediates involved in the synthesis..
Biophore India Pharmaceuticals Pvt. Ltd.

Meldrum's acid, barbituric acid and pyrazolone derivatives substituted with hydroxylamine as hno donors

The disclosed subject matter provides certain n-substituted hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or development of a disease or condition.
The Johns Hopkins University

Multipurpose exercise training device

An exercise device having many advantageous features is described, including the ability to provide users with multiple modes of training by transforming the device into different configurations. Users can exercise their cardiovascular endurance by using the device in its jump rope configuration.

Comprehensive cardiovascular analysis with volumetric phase-contrast mri

Processing techniques of volumetric anatomic and vector field data from volumetric phase-contrast mri on a magnetic resonance imaging (mri) system are provided to evaluate the physiology of the heart and vessels. This method includes the steps of: (1) correcting for phase-error in the source data, (2) visualizing the vector field superimposed on the anatomic data, (3) using this visualization to select and view planes in the volume, and (4) using these planes to delineate the boundaries of the heart and vessels so that measurements of the heart and vessels can be accurately obtained..
The Board Of Trustees Of The Leland Stanford Junior University

Mangifera indica as a sirtuin 1 activating agent

The invention relates to a mangifera (mango) indica preparation as sirtuin 1 activating agent for in vivo and in vitro applications. The preparation may be used to reduce the risk of developing obesity, type ii diabetes, elevated blood lipid levels, artheriosclerosis and cardiovascular diseases, as well as a cell and dna protector..
Vital Solutions Swiss Ag

Macrocyclic ghrelin receptor modulators and methods of using the same

The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth hormone sceretagogue receptor, ghs-r1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein.
Ocera Therapeutics, Inc.

Heart and peripheral vascular valve replacement in conjunction with a support ring

An implantable valve replacement system for a cardiovascular valve may include an adjustable stabilizing ring. The stabilizing ring may be composed of a body member that is transitionable from an elongate insertion geometry to an annular operable geometry.
Valcare, Inc.

Fixation devices, engaging tissue

The invention provides devices, systems and methods for tissue approximation and repair at treatment sites. The devices, systems and methods of the invention will find use in a variety of therapeutic procedures, including endovascular, minimally-invasive, and open surgical procedures, and can be used in various anatomical regions, including the abdomen, thorax, cardiovascular system, heart, intestinal tract, stomach, urinary tract, bladder, lung, and other organs, vessels, and tissues.
Evalve, Inc.

System and methods to predict serum lactate level

A method to quantitatively predict a patient's serum lactate level, comprising measuring arterial blood pressure and heart rate from the patient, computing estimates of one or more cardiovascular parameters from the measured arterial blood pressure and heart rate, providing one or more classifiers that have been trained on a training data set including a reference set of arterial blood pressure, heart rate, and serum lactate levels and using the one or more classifiers to estimate the serum lactate level of the patient.. .
The General Hospital Corporation

Feed compositions comprising ricinodendron heudelotii and methods of processing and using thereof

The compositions, methods, and system of the invention provide increased nutrients and kidney size and reduced fat and risks of cardiovascular disease in animals by utilizing njangsa (ricinodendron heudelotii) as a feed and oral supplement for the animals.. .



Cardiovascular topics:
  • Cardiovascular
  • Vascular Disease
  • Cardiovascular Disease
  • Vascular Diseases
  • Hypertension
  • Antimicrobial Agents
  • Antimicrobial
  • Inflammatory Disease
  • Antimicrobial Agent
  • Steoporosis
  • Osteoporosis
  • Medical Device
  • Cardiovascular System
  • Electrical Signal
  • Implantable Medical Device


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    This listing is a sample listing of patent applications related to Cardiovascular for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Cardiovascular with additional patents listed. Browse our RSS directory or Search for other possible listings.


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