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Cardiovascular

Cardiovascular-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Biomarkers of oxidative stress
Northern Sydney Local Health District
July 13, 2017 - N°20170199200

The present invention relates to a method for detecting cardiovascular oxidative stress in an individual, comprising detecting in a blood sample from the individual modification of a cysteine at position 45 of the β1-subunit of the human erythrocyte atp-dependent na+k+ pump protein or of an equivalent cysteine in a homologue or variant thereof. The invention further relates to ...
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 13, 2017 - N°20170198253

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
July 13, 2017 - N°20170197989

The present invention provides compounds of formula (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
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Cardiovascular Patent Applications
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inventor
  • 516+ full patent PDF documents of Cardiovascular-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
July 13, 2017 - N°20170197964

The present invention provides compounds of formula i and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Agonists of the apelin receptor and methods of use thereof
Sanford-burnham Medical Research Institute
July 13, 2017 - N°20170197958

Provided herein are small molecule agonists of the apelin receptor for the treatment of disease. The compounds disclosed herein are useful for the treatment of a range of cardiovascular, renal and metabolic conditions. The present invention is based on the seminal discovery of a series of potent small molecule agonists of the apelin receptor, which are useful for the treatment ...
Nickel titanium oxide coated articles
The Regents Of The University Of California
July 13, 2017 - N°20170197015

This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may ...
Cardiovascular Patent Pack
Download 516+ patent application PDFs
Cardiovascular Patent Applications
Download 516+ Cardiovascular-related PDFs
For professional research & prior art discovery
inventor
  • 516+ full patent PDF documents of Cardiovascular-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Reconstituted high density lipoprotein formulation and production method thereof
Csl Limited
July 13, 2017 - N°20170196935

A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as apoai or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50 g/l and the molar ratio of apolipoprotein:...
Tgr5 agonist complexes for treating diabetes and cancer
City Of Hope
July 13, 2017 - N°20170196890

Provided herein are complexes of metformin or metformin analogues and a tgr5 ligand that are useful in treating diseases including diabetes, cardiovascular disease, and cancer.
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 13, 2017 - N°20170196858

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 13, 2017 - N°20170196857

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
Apoptosis signal-regulating kinase inhibitors
The John Hopkins University
July 13, 2017 - N°20170196844

Wherein x1, x2, x3, x4, x5, x6, x7, x8, r1, r2, r3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or ...
Hydrogel compositions comprising encapsulated cells and methods of use thereof
President And Fellows Of Harvard College
July 13, 2017 - N°20170196818

The present invention provides injectable compositions comprising cells encapsulated in hydrogel capsules and methods of preparing these compositions. The present invention also provides methods for using these compositions to promote hematopoiesis and to treat or prevent cardiovascular and immunological disorders in a subject.
Structural members for prosthetic mitral valves
Tendyne Holdings, Inc.
July 13, 2017 - N°20170196688

A self-expanding wire frame for a pre-configured compressible transcatheter prosthetic cardiovascular valve, a combined inner frame/outer frame support structure for a prosthetic valve, and methods for deploying such a valve for treatment of a patient in need thereof, are disclosed.
Cardiovascular Patent Pack
Download 516+ patent application PDFs
Cardiovascular Patent Applications
Download 516+ Cardiovascular-related PDFs
For professional research & prior art discovery
inventor
  • 516+ full patent PDF documents of Cardiovascular-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Compositions and methods for inhibiting bmp
The Brigham And Woman's Hospital, Inc.
July 06, 2017 - N°20170190705

The present invention provides small molecules inhibitors of bmp signaling and compositions and methods for inhibiting bmp signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as ...
Pyridine and pyridimine compounds as pi3k-gamma inhibitors
Incyte Corporation
July 06, 2017 - N°20170190689

The present disclosure provides compounds of formula i, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (pi3kγ) and are useful in the treatment of diseases related to the activity of pi3kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
Bacteroides cect 7771 and the use thereof in the prevention and treatment of excess weight, obesity ...
Consejo Superior De Investigaciones Cientificas
July 06, 2017 - N°20170189456

The invention relates to a strain of bacteroides uniformes with registration number cect 7771, and to the cellular constituents, metabolites and/or secreted molecules thereof. The invention also relates to a composition (nutritional or pharmaceutical) comprising at least one of the previous products. The invention further relates to the use of a strain of bacteroides uniforms, preferably cect 7771, or of the ...
Treating arrhythmia with mitochondrial-targeted antioxidants
Rhode Island Hospital
July 06, 2017 - N°20170189429

This invention relates to reducing the risk of arrhythmias as a result of an acute cardiovascular disorder or injury such as a myocardial infarction by using mitochondrial-targeted antioxidants to improve cardiac function.
Fluorinated benzofuran derivatives
Scifluor Life Sciences, Inc.
July 06, 2017 - N°20170189370

The invention relates to fluorinated compounds and their use in the field of pathological syndromes of the cardiovascular system. Novel fluorinated benzofuran derivatives of amiodarone and pharmaceutically acceptable salts or solvates thereof and their use for the treatment of arrhythmias are described.
Bioabsorbable polymeric medical device
Orbusneich Medical Inc.
July 06, 2017 - N°20170189211

In embodiments there is described a cardiovascular tube-shaped lockable and expandable bioabsorbable scaffold having a low immunogenicity manufactured from a crystallizable bioabsorbable polymer composition or blend.
Mechanical model of the cardiovascular system and method of demonstrating the physiology of the cardiovascular ...
The University Of Scranton
June 29, 2017 - N°20170186341

A hydraulic model of the cardiovascular system for illustrating a plurality of physiological concepts and relationships including arterial compliance, venous compliance, and peripheral resistance, said model comprising: a.) a cardiac subsystem for moving a fluid in a singular direction in a closed hydraulic system; b.) an arterial subsystem for modeling arterial compliance, the arterial subsystem fluidically coupled with the cardiac ...
Drug delivery system with delivery based on patient data
Ethicon Endo-surgery, Inc.
June 29, 2017 - N°20170185742

Patient demographics gathered from a variety of sources are used to create one or more cumulative risk factors that is used to configure a set of initial drug delivery rules controlling factors such as dosing limits, lockouts, alarm thresholds, and informational displays. These initial drug delivery rules may then be modified during a procedure according to a pharmacodynamic profile that ...
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