Cardiovascular

Cardiovascular-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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NEW Phoenixin peptides
May 25, 2017 - N°20170145083

Human phoenixin peptides, analogs and mimetics useful in production of anti-phoenixin antibodies, diagnostic screening and assays, and in modulating cellular concentration of camp, and treatment of disorders related to camp or ca2+ concentration in cells, modulating hypertension and cardiovascular function, modulating gonadotrophs and gastric emptying.
NEW Cyclic thienouracil-carboxamides and use thereof
May 25, 2017 - N°20170145029

The present application relates to novel 2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxamide derivatives (“thienouracil”-carboxamides), to processes for their preparation, to their use alone or in combinations for the treatment and/or prevention of diseases and to their use for the preparation of medicaments for the treatment and/or prevention of diseases, in particular for the treatment ...
NEW Diazepane derivatives and uses thereof
May 25, 2017 - N°20170145023

The present disclosure provides compounds of formula (i), and pharmaceutically compositions thereof. Compounds of formula (i) have been found to bind bromodomains and/or bromodomain-containing proteins (e. G., bromo and extra terminal (bet) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e. G., increased activity) of bromodomains and/or bromodomain-containing ...
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NEW Substituted pyrazino[2,2-a]isoquinoline derivatives
May 25, 2017 - N°20170145010

The present invention relates to compounds of formula of formula i wherein r, r2and l are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
NEW Substituted azetidine derivatives
May 25, 2017 - N°20170144994

The present invention relates to compounds of formula of formula i wherein r, r1. R2, r2′, r3, r4, r5, l1, l2 and n are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
NEW Modulators of the relaxin receptor 1
May 25, 2017 - N°20170144984

Disclosed are modulators of the human relaxin receptor 1, for example, of formula (i), wherein a, r1, and r2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e. G., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method ...
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NEW Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
May 25, 2017 - N°20170143658

In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dl to about 500 mg/dl, and administering to the subject ...
NEW Compositions and methods for reducing a fatty acid desaturation index in a subject in need ...
May 25, 2017 - N°20170143657

In various embodiments, the present invention provides compositions and methods for treating and/or preventing cardiovascular-related diseases in subject in need thereof.
NEW Methods of reducing the risk of a cardiovascular event in a subject on statin therapy
May 25, 2017 - N°20170143656

In various embodiments, the present invention provides methods of reducing the risk of a cardiovascular event in a subject on statin therapy and, in particular, a method of reducing the risk of a cardiovascular event in a subject on statin therapy having a fasting baseline triglyceride level of about 135 mg/dl to about 500 mg/dl, and administering to the subject ...
NEW Mobile communication device and other devices with cardiovascular monitoring capability
May 25, 2017 - N°20170143205

A general-purpose mobile communication device, general-purpose computer user-interface device, and other non-health-related electronic devices with cardiovascular monitoring capability. Various aspects of the present invention may comprise a general-purpose mobile communication device (e. G., a cellular telephone, portable email device, personal digital assistant, etc.) comprising a communication interface module adapted to communicate with a general-purpose communication network, and at least one ...
New markers for the assessment of the risk for development of a cardiovascular disorder
Mcmaster University
May 18, 2017 - N°20170138961

The present invention relates to the assessment of the risk for development of a cardiovascular disorder. It discloses the use of biochemical markers in the assessment of the risk for development of a cardiovascular disorder. It also relates to the use of the biochemical markers or marker panels for the assessment of the risk for development of a cardiovascular disorder ...
Compositions and methods for treating cardiovascular disease and myocardial infarction with dipeptidyl peptidase inhibitors or ...
Alere San Diego, Inc.
May 18, 2017 - N°20170138932

The present invention describes compositions and methods for treating cardiovascular disease and myocardial infarction using dipeptidyl peptidase inhibitors. Also provided are methods for increasing natriuretic peptide function by administering one or more analogues of b type natriuretic peptide that provide increased stability in the presence of prolyl-specific dipeptidyl peptidases.
Organic compositions to treat apoc3-related diseases
Arrowhead Pharmaceuticals, Inc.
May 18, 2017 - N°20170137814

The present disclosure relates to compositions and methods for treating apoc3-related diseases such as: hypertriglyceridemia (e. G., type v hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a rnai agent to apoc3.
Cardiovascular Patent Pack
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  • 516+ full patent PDF documents of Cardiovascular-related inventions.
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2-oxa-5-azabicyclo[2.2.1]heptan-3-yl derivatives
Hoffmann-la Roche Inc.
May 18, 2017 - N°20170137435

The present invention relates to compounds of formula of formula i wherein x, l and r1 are as described herein, compositions containing compounds of formula i, methods of manufacture of compounds of formula i and methods of treating psychiatric, metabolic, cardiovascular or sleep disorders with compounds of formula i.
Thioredoxin or thioredoxin derivatives or peptides for the treatment of high blood pressure
Texas Tech University System
May 18, 2017 - N°20170136100

The present invention provides methods and compositions for the treatment of cardiovascular disorders comprising: a therapeutically effective amount of thioredoxin-1 or a thioredoxin-1 derivative in a pharmaceutical carrier to ameliorate one or more symptom of a cardiovascular disorder.
Compositions comprising eicosapentaenoic acid and mipomersen and methods of use thereof
Amarin Pharmaceuticals Ireland Limited
May 18, 2017 - N°20170136055

The present invention relates to, inter alia, pharmaceutical compositions comprising a polyunsaturated fatty acid and to methods of using the same to treat or prevent cardiovascular-related diseases.
Gigahertz frequency fringing near-field cardiovascular sensor
Amarin Pharmaceuticals Ireland Limited
May 18, 2017 - N°20170135600

A near-field sensor method and device for obtaining cardiovascular information is disclosed. A transmission-line aperture arrangement configured to guide electromagnetic waves and emit near-field fringing energy, is placed near the skin. The transmission line is excited at a narrow-band gigahertz frequency. The near-field fringing energy emitted by the sensor device penetrates at least partially into the skin and underlying blood ...
Blood pressure monitor coordinated with a cardiovascular health condition monitoring module
Acme Portable Machines, Inc.
May 18, 2017 - N°20170135585

A blood pressure monitor equipped with a cardiovascular health condition monitoring module includes: a blood pressure measurement device measuring a user's blood pressure signal; a host including a blood pressure monitor microprocessor that processes blood pressure correlated signal; a control panel equipped to the host and configured to control blood pressure measured by the blood pressure monitor and heart rhythm ...
Natriuretic polypeptides
Mayo Foundation For Medical Education And Research
May 11, 2017 - N°20170129934

This document provides methods and materials related to natriuretic polypeptides and the use of natriuretic polypeptides to treat cardiovascular and/or renal conditions. For example, chimeric polypeptides having at least one amino acid segment (e. G., n-terminus tail, ring structure, c-terminus tail, or a combination thereof) of a natriuretic peptide (e. G., anp, bnp, cnp, uro, or dnp) and an ...
Heterocyclic compounds as pi3k-y inhibitors
Mayo Foundation For Medical Education And Research
May 11, 2017 - N°20170129899

Or pharmaceutically acceptable salts or stereoisomers thereof, which are inhibitors of pi3k-γ which are useful for the treatment of disorders such as autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
Triazolopyridazine derivatives as modulators of tnf activity
Ucb Biopharma Sprl
May 11, 2017 - N°20170129894

A series of substituted [1,2,4]triazolo[4,3-b]pyridazine derivatives of formula (i), being potent modulators of human tnfa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.