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Cardiovascular Disease

Cardiovascular Disease-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 13, 2017 - N°20170198253

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
Inhibitors of the renal outer medullary potassium channel
Merck Sharp & Dohme Corp.
July 13, 2017 - N°20170197989

The present invention provides compounds of formula (i) and the pharmaceutically acceptable salts thereof, which are inhibitors of the romk (kir1. 1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt ...
Compositions and methods for inhibiting bmp
University Of Houston System
July 13, 2017 - N°20170197968

The present invention provides small-molecule inhibitors of bmp signaling and compositions and methods for inhibiting bmp signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for ...
Cardiovascular Disease Patent Pack
Download 215+ patent application PDFs
Cardiovascular Disease Patent Applications
Download 215+ Cardiovascular Disease-related PDFs
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inventor
  • 215+ full patent PDF documents of Cardiovascular Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Nickel titanium oxide coated articles
The Regents Of The University Of California
July 13, 2017 - N°20170197015

This disclosure relates to an article comprising at least one substrate and at least one porous coating formed on the at least one substrate. The substrate may be a medical device, for example a nitinol stent. The porous coating may comprise a nanotubular coating. The nanotubular coating may comprise a compound of nickel, titanium and oxygen. This porous coating may ...
Cardiovascular disease treatment and prevention
Transdermal Biotechnology, Inc.
July 13, 2017 - N°20170196981

The present invention generally relates to compositions and methods for treatment of subjects having or at risk of arteriosclerosis, hypertension, sickle-cell anemia, or other conditions. In some cases, the composition may include nitric oxide, peptides, or both. The nitric oxide and/or peptide may be present within a first phase comprising a lecithin, such as phosphatidylcholine. In certain embodiments, the ...
Reconstituted high density lipoprotein formulation and production method thereof
Csl Limited
July 13, 2017 - N°20170196935

A reconstituted high density lipoprotein formulation having relatively low toxicity comprises an apolipoprotein such as apoai or fragment thereof, a lipid and a detergent at a level which is about 5-50% of that which would normally cause liver toxicity upon administration to a human. The lipid is optimally phosphatidylcholine at about 30-50 g/l and the molar ratio of apolipoprotein:...
Cardiovascular Disease Patent Pack
Download 215+ patent application PDFs
Cardiovascular Disease Patent Applications
Download 215+ Cardiovascular Disease-related PDFs
For professional research & prior art discovery
inventor
  • 215+ full patent PDF documents of Cardiovascular Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 13, 2017 - N°20170196858

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
The John Hopkins University
July 13, 2017 - N°20170196857

Methods are provided herein for selectively killing senescent cells and for treating senescence-associated diseases and disorders by administering a senolytic agent. Senescence-associated diseases and disorders treatable by the methods using the senolytic agents described herein include cardiovascular diseases and disorders associated with or caused by arteriosclerosis, such as atherosclerosis; idiopathic pulmonary fibrosis; chronic obstructive pulmonary disease; osteoarthritis; senescence-associated ophthalmic diseases ...
Apoptosis signal-regulating kinase inhibitors
The John Hopkins University
July 13, 2017 - N°20170196844

Wherein x1, x2, x3, x4, x5, x6, x7, x8, r1, r2, r3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or ...
Compositions and methods for inhibiting bmp
The Brigham And Woman's Hospital, Inc.
July 06, 2017 - N°20170190705

The present invention provides small molecules inhibitors of bmp signaling and compositions and methods for inhibiting bmp signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with bmp signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as ...
Pyridine and pyridimine compounds as pi3k-gamma inhibitors
Incyte Corporation
July 06, 2017 - N°20170190689

The present disclosure provides compounds of formula i, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (pi3kγ) and are useful in the treatment of diseases related to the activity of pi3kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
Bacteroides cect 7771 and the use thereof in the prevention and treatment of excess weight, obesity ...
Consejo Superior De Investigaciones Cientificas
July 06, 2017 - N°20170189456

The invention relates to a strain of bacteroides uniformes with registration number cect 7771, and to the cellular constituents, metabolites and/or secreted molecules thereof. The invention also relates to a composition (nutritional or pharmaceutical) comprising at least one of the previous products. The invention further relates to the use of a strain of bacteroides uniforms, preferably cect 7771, or of the ...
Cholesteryl ester transfer protein (cetp) inhibitor and pharmaceutical compositions comprising said inhibitor for use in ...
Consejo Superior De Investigaciones Cientificas
June 29, 2017 - N°20170182048

(hereinafter referred to as compound a) for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, in particular hyperlipidemia or mixed dyslipidemia. A further aspect of the present invention relates to a pharmaceutical composition for use in the treatment of subjects suffering from or having an increased risk for cardiovascular diseases, wherein the ...
Cardiovascular Disease Patent Pack
Download 215+ patent application PDFs
Cardiovascular Disease Patent Applications
Download 215+ Cardiovascular Disease-related PDFs
For professional research & prior art discovery
inventor
  • 215+ full patent PDF documents of Cardiovascular Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Apoptosis signal-regulating kinase inhibitors
Institut National De La Sante Et De La Recherche Medicale (inserm)
June 22, 2017 - N°20170173031

Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver ...
Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk
Elcelyx Therapeutics, Inc.
June 15, 2017 - N°20170165209

Compositions and methods comprising at least one biguanide compound and at least one statin combined with at least one additional active agent in fixed dose combinations are provided for reducing cardiometabolic risk, and for the treatment of cardiovascular disease, wherein the biguanide compound is formulated for delayed release.
Systems and methods for vessel reactivity to guide diagnosis or treatment of cardiovascular disease
Heartflow, Inc.
June 08, 2017 - N°20170156679

Systems and methods are disclosed for using vessel reactivity to guide diagnosis or treatment for cardiovascular disease. One method includes receiving a patient-specific vascular model of a patient's anatomy, including at least one vessel of the patient; determining, by measurement or estimation, a first vessel size at one or more locations of a vessel of the patient-specific vascular model at ...
Benzimidazole compounds and their application in cardiovascular diseases
National Taiwan University
June 01, 2017 - N°20170152245

The present invention provides substituted benzimidazoles, pharmaceutical composition comprising the substituted benzimidazoles, and their use for preventing or treating a subject suffering from diseases or conditions associated with platelet activation aggregation and/or platelet activation.
Diazepane derivatives and uses thereof
National Taiwan University
May 25, 2017 - N°20170145023

The present disclosure provides compounds of formula (i), and pharmaceutically compositions thereof. Compounds of formula (i) have been found to bind bromodomains and/or bromodomain-containing proteins (e. G., bromo and extra terminal (bet) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e. G., increased activity) of bromodomains and/or bromodomain-containing ...
Dihydropteridinone derivatives and uses thereof
National Taiwan University
May 25, 2017 - N°20170145013

The present disclosure provides compounds of formula (i), and pharmaceutically compositions thereof. Compounds of formula (i) have been found to bind bromodomains and/or bromodomain-containing proteins (e. G., bromo and extra terminal (bet) proteins). Also provided are methods, uses, and kits of the compounds and pharmaceutical compositions for inhibiting the activity (e. G., increased activity) of bromodomains and/or bromodomain-containing ...
Modulators of the relaxin receptor 1
National Taiwan University
May 25, 2017 - N°20170144984

Disclosed are modulators of the human relaxin receptor 1, for example, of formula (i), wherein a, r1, and r2 are as defined herein, that are useful in treating mammalian relaxin receptor 1 mediated facets of human health, e. G., cardiovascular disease. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the disclosure, and a method ...
Compositions and methods for treating cardiovascular disease and myocardial infarction with dipeptidyl peptidase inhibitors or ...
Alere San Diego, Inc.
May 18, 2017 - N°20170138932

The present invention describes compositions and methods for treating cardiovascular disease and myocardial infarction using dipeptidyl peptidase inhibitors. Also provided are methods for increasing natriuretic peptide function by administering one or more analogues of b type natriuretic peptide that provide increased stability in the presence of prolyl-specific dipeptidyl peptidases.
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