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Cancer patents

      

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 Method for suggesting the stage of progression of pancreatic cancer patent thumbnailMethod for suggesting the stage of progression of pancreatic cancer
A method for suggesting a stage of progression of pancreatic cancer, includes: a first process of measuring a concentration of s100p or cea in the duodenal juice; a second process of measuring a concentration of ca19-9 in a blood sample of the subject; and a third process of comparing the concentration of s100p or cea with a first cutoff value, comparing the concentration of ca19-9 with a second cutoff value, suggesting the stage of progression of the pancreatic cancer based on the concentration of the s100p or cea as an early stage, as a middle stage, or as a stage more progressed than the middle stage.. .
Olympus Corporation


 Novel methods, bioassays, and biomarkers for hpv-related conditions patent thumbnailNovel methods, bioassays, and biomarkers for hpv-related conditions
Provided herein are methods for the rapid detection of hpv types, such as hpv 16- and hpv18-specific antibodies, in patient samples that contain antibodies. For example, patients with head and neck cancers have detectable antibodies to multiple early genes derived from hpv.
Arizona Board Of Regents On Behalf Of Arizona State University


 Intertumoral homogeneity determined by mick assay patent thumbnailIntertumoral homogeneity determined by mick assay
The use of genomic tests shows variability between the primary tumor and the metastases in most circumstances referred to as tumor heterogeneity. Since it is unduly invasive and difficult to obtain samples from the primary and metastatic tumors within a patient, a need exists for a method of testing chemotherapeutic effectiveness in a patient that is applicable to both primary tumor and metastases.
Diatech Oncology, Llc


 Six-gene biomarker of survival and response to platinum based chemotherapy in serious ovarian cancer patients patent thumbnailSix-gene biomarker of survival and response to platinum based chemotherapy in serious ovarian cancer patients
Described herein are methods of predicting the risk of developing ovarian cancer recurrence of a subject comprising the steps of detecting the expression levels of at least four of the six genes selected from the group consisting of akt2, kras, rac1, calm3, rps6ka2 and ywhab or the gene products thereof, wherein the presence of increased expression levels of the genes or the gene products is predictive of the increased risk of developing ovarian cancer recurrence in the subject. Kits for practicing the methods are also disclosed..
The Medical College Of Wisconsin, Inc.


 Methods of detecting signatures of disease or conditions in bodily fluids patent thumbnailMethods of detecting signatures of disease or conditions in bodily fluids
Methods and compositions for diagnosing the presence of a cancer cell in an individual are provided. Methods and compositions for identifying a tumor-specific signature in an individual having cancer are also provided.
President And Fellows Of Harvard College


 Methods and materials for identifying and treating mammals having her2-positive breast cancer patent thumbnailMethods and materials for identifying and treating mammals having her2-positive breast cancer
This document provides methods and materials involved in identifying mammals having breast cancer (e.g., her2-positive breast cancer) responsive to trastuzumab as well as methods and materials involved in treating mammals having breast cancer (e.g., her2-positive breast cancer) responsive to trastuzumab. For example, methods and materials for using expression level profiles to identify mammal having her2-positive breast cancer with an increased likelihood of being responsive to trastuzumab are provided..
Mayo Foundation For Medical Education And Research


 Profiling chemically modified dna/rna units for disease and cancer diagnosis patent thumbnailProfiling chemically modified dna/rna units for disease and cancer diagnosis
The present invention relates to high-throughput methods comprising direct infusion electrospray ionization mass spectrometry (esi-ms), multistep tandem mass spectrometry (msn), consecutive reaction monitoring (crm), ion mobility spectrometry mass spectrometry (ims-ms), high-resolution ms, and ims-ms, for genome-wide (whole cell or tissue) profiling of dna and rna nucleotides/nucleosides having a wide variety of variant structural modifications. In particular, these methods are contemplated for providing a specific profile of variant dna and/or rna chemically modified nucleic acids (i.e.
The Research Foundation For The State University Of New York


 Detection of brain cancer patent thumbnailDetection of brain cancer
Provided are methods for detecting brain cancer in a subject, methods of predicting a clinical outcome in a patient with brain cancer, methods of monitoring the progression of brain cancer in a patient, and methods of grading a patient's brain cancer. The methods utilise various micro rnas that the inventors have found to be useful in these manners..
University Of Central Lancashire


 Immunotherapy with binding agents patent thumbnailImmunotherapy with binding agents
The present invention provides agents, such as soluble receptors, antibodies, and small molecules that modulate the immune response. In some embodiments, the agents activate or increase the immune response to cancer and/or a tumor.
Oncomed Pharmaceuticals


 Compositions and methods to enhance the immune system patent thumbnailCompositions and methods to enhance the immune system
The invention relates to the field of molecular medicine. In particular, it relates to compositions and methods to enhance the clearance of aberrant cells, e.g.
Stichting Sanquin Bloedvoorziening


Human sperm fibrous sheath (fs) proteins: new target antigens for use in therapeutic cancer vaccines and diagnostic screening and methods of using same

cancer vaccines were demonstrated to be promising strategies for cancer treatment; however these strategies are limited by the paucity of target antigens that provoke an effective immune response. The inventors of the present patent application propose that sperm fibrous sheet proteins constitute a new class of potential antigens for use in the development of effective, durable cancer vaccines.
Kiromic, Llc

Histone deacetylase inhibitors and methods for use thereof

The present invention relates to methods of modulating (for example inhibiting) activity of histone deacetylases (hdacs) and/or treating hdacs—associated diseases including, for example, cancers, inflammatory disorders, neurodegenerative disorders, etc. The invention also provides novel compounds and compositions thereof, methods of preparation of the same, as well as methods of use of the same for inhibition of hdacs and/or treatment of hdac-associated diseases..
Reaction Biology Corp.

Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers

A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (az 1-15) and alkynes (ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (mdr) in p-gp-overexpressed cell line (lcc6mdr), mrp1-overexpressed cell line (2008/mrp1) and bcrp-overexpressed cell line (hek293/r2 and mcf7-mx100).
Mcgill University

Tetra-o-substituted butane-bridge modified ndga derivatives, their synthesis and pharmaecutical use

The present invention relates to nordihydroguaiaretic acid derivative compounds, namely, butane bridge modified nordihydroguaiaretic acid (ndga) compounds and butane bridge modified tetra-o-substituted ndga compounds, pharmaceutical compositions containing them, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as hiv infection, hpv infection, or hsv infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, metabolic diseases, such as diabetes and hypertension, or a proliferative disease, such as diverse types of cancers.. .
Erimos Pharmaceuticals Llc

Pyrimidine compounds and use as anti-cervical cancer thereof

Provided is use of a pyrimidine compound or a pharmaceutically acceptable salt thereof in preparation of an anti-cervical cancer medicament. Research of the present invention has found that the above-mentioned pyrimidine compound can be effective against cervical cancer, and has a good inhibition effect on e6 and e7 of hpv16, and indicates that the above-mentioned pyrimidine compound also has a good anti-human papilloma virus effect, providing a new choice for clinical medication..
Sichuan University

Inhibitors of jmjd2c as anticancer agents

The present disclosure provides compounds, pharmaceutical compositions and related methods for the treatment of cancer, e.g., castration-resistant prostate cancer (crpc). Specifically, the present disclosure provides a series of 8-hydroxyquinoline derivatives which show cytotoxic effects on androgen-independent prostate cancer cells..
The J. David Gladstone Institutes

Crystalline solid forms of n--n'-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide, processes for making, and methods of use

The invention relates to novel crystalline solid forms of the chemical compound n-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]phenyl}-n′-(4-fluorophenyl) cyclopropane-1,1-dicarboxamide (compound 1), and solvates thereof, including hydrates, that are useful for the treatment of cancer. Also disclosed are pharmaceutical compositions comprising the crystalline solid forms and processes for making the crystalline solid forms, as well as methods of using them for the treatment of cancer, particularly thyroid cancer, prostate cancer, hepatocellular cancer, renal cancer, and non-small cell lung carcinoma.
Exelixis, Inc.

Heterodimers of glutamic acid

R′ is h, c(o), s(o)2, c(o)2, a c6-c12 substituted or unsubstituted aryl, a c6-c12 substituted or unsubstituted heteroaryl or a c1-c6 substituted or unsubstituted alkyl, when substituted, aryl, heteroaryl and alkyl are substituted with halogen, c6-c12 heteroaryl, —nr′r′ or cooz, which have diagnostic and therapeutic properties, such as the treatment and management of prostate cancer and other diseases related to naaladase inhibition, radiolabels can be incorporated into the structure through a variety of prosthetic groups attached at the x amino acid side chain via a carbon or hetero atom linkage.. .

Methods and compositions for treating metastatic breast cancer and other cancers in the brain

A composition comprising at least one aav vector formulated for central nervous system delivery is described. The composition comprises at least one expression cassette which contains sequences encoding an anti-neoplastic immunoglobulin construct for delivery to the brain operably linked to expression control sequences therefor and a pharmaceutically acceptable carrier.
The Trustees Of The University Of Pennsylvania

Methods of using anti-steap1 antibodies and immunoconjugates

Provided herein are methods of treating prostate cancer in particular androgen receptor inhibitor nave prostate cancer using anti-steap-1 antibodies and immunoconjugates thereof.. .
Genentech, Inc.

Combination vaccine devices and methods of killing cancer cells

The present invention comprises compositions, methods, and devices for enhancing an endogenous immune response against a cancer. Devices and methods provide therapeutic immunity to subjects against cancer..
Dana-farber Cancer Institute, Inc.

Compositions having means for targeting at least one antigen to dendritic cells

A composition that can be used as a vaccine containing means for targeting at least one antigen to dendritic cells and as adjuvants a granulocyte macrophage colony stimulating factor and a cpg oligodeoxynucleotide and/or a cpg-like oligodeoxynucleotide. This composition can used to treat cancers, infectious diseases caused by bacterial, viral, fungal, parasitic or protozoan infections, allergies and/or autoimmune diseases..
Universite Paris Descartes

Multi-indication mrna cancer immunotherapy

Synthetic bacterial messenger rna can be used to prepare autologous, allogenic or direct nucleic acid cancer vaccines. Cancer cells are transfected either in vitro or in vivo with mrna obtained from dna that encodes an immunogenic bacterial protein.
Morphogenesis, Inc.

Effective treatment of ovarian cancer using triciribine and related compounds

The inventors have determined, contrary to the prior art and experience, how to successfully use triciribine to treat ovarian cancer by one or a combination of (i) administering triciribine only to patients which according to a diagnostic test described below, exhibit enhanced sensitivity to the drug; (ii) use of a described dosage level that minimizes the toxicity of the drug but yet still exhibits efficacy; or (iii) use of a described dosage regimen that minimizes the toxicity of the drug.. .
University Of South Florida

Procaspase combination therapy for glioblastoma

The invention provides compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells.
The Johns Hopkins University

Treatment of h-ras-driven tumors

The present disclosure describes a compositions and methods for treatment of hras-driven cancers. Administration of a farnesyltransferase inhibitor, for example, tipifarnib, alone or in combination with a mek inhibitor can reduce tumor size and tumor growth in cancers such as poorly differentiated thyroid cancer (pdtc) and anaplastic thyroid cancer (atc)..
Memorial Sloan-kettering Cancer Center

Method of treating lung adenocarcinoma

This invention is directed to the treatment of cancer in a patient, particularly a patient with lung adenocarcinoma, and more particularly a patient with slc34a2-ros1, cd74-ros1, or fig-ros1 fusion-positive non-small cell lung cancer, with an inhibitor of met, vegfr2, and ros1 which is a compound of formula (i): or a pharmaceutically acceptable salt thereof.. .
Exelixis, Inc.

Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof

Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers..
Ions Pharmaceutical S.à R.l.

Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof

Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers..
Ions Pharmaceutical S.à R.l.

Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof

Human therapeutic treatment compositions comprise at least two of a curcumin component, a harmine component, and an isovanillin component, and preferably all three in combination. The agents are effective for the treatment of human conditions, especially human cancers..
Ions Pharmaceutical S.à R.l.

Nanoparticles comprising docetaxel for treating cancers having a k-ras mutation

The present disclosure relates in part to methods of treating cancers having a mutation in a ras gene in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a nanoparticle composition, wherein the nanoparticle composition comprises nanoparticles.. .
Bind Therapeutics, Inc.

Acetylcysteine composition and uses thereof

This invention relates to novel acetylcysteine compositions in solution, comprising acetylcysteine and which are substantially free of metal chelating agents, such as edta. Further, this invention relates to methods of making and using the acetylcysteine compositions.
Cumberland Pharmaceuticals, Inc.

Nanoparticles for targeted gene therapy and methods of use thereof

The present disclosure provides targeted, polymeric nanoparticles which facilitate the delivery of small interfering rnas, mirnas and shrna expressing plasmid dnas and include an aggregate of nucleic acids and polycationic polymer scaffolds. Methods of making and using such nanoparticles are provided as are methods of treating cancer, including glioblastoma multiforme, prostate cancer and melanoma using such nanoparticles..
Avrygen Corporation

Lung targeting dual drug delivery system

The american cancer society estimated that in 2009, 1,479,350 new cancer cases would be diagnosed in the united states of which 219,440 would be lung and bronchus related. The standard treatments for nsclc include surgery, chemotherapy, radiation, laser and photodynamic therapy, all with various success rates depending on the stage of the cancer.
Rutgers, The State University Of New Jersey

Animal models for cancer and uses thereof

Non-human animal cancer models are provided herein for identifying and characterizing agents useful for therapy and prophylaxis of cancers, including agents useful for diminishing side effects related to cancer therapies and reducing metastatic disease.. .
Mayo Foundation For Medical Education And Research





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This listing is a sample listing of patent applications related to Cancer for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Cancer with additional patents listed. Browse our RSS directory or Search for other possible listings.


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