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Brain patents

      

This page is updated frequently with new Brain-related patent applications.

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new patent Auto-calibration of probabilistic tracking parameters for dti fibre tractography and compilation of tract probability comparison scales
1. A medical data processing method of determining information describing the probable position of a neural fibre in a patient's brain, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring patient-specific medical image data describing the brain of the patient; b) acquiring atlas data defining an image-based model of a human brain; c) determining, based on the patient-specific medical image data and the atlas data, seed region data describing seed regions (a, b) in the patient-specific medical image data in which the ends of neural fibres of the patient's brain may be located; d) determining, based on the patient-specific medical image data and the seed region data, neural fibre tract data describing a plurality of potential tracts (t1, t2, t3) which a specific neural fibre may take through the patient's brain; e) determining, based on the atlas data and the neural fibre tract data, a figure of merit for each one of the potential tracts (t1, t2, t3)..
Brainlab Ag


new patent Method and constructing a neuroscience-inspired artificial neural network with visualization of neural pathways
A method and apparatus for constructing one of a neuroscience-inspired artificial neural network and a neural network array comprises one of a neuroscience-inspired dynamic architecture, a dynamic artificial neural network array and a neural network array of electrodes associated with neural tissue such as a brain, the method and apparatus having a special purpose display processor. The special purpose display processor outputs a display over a period of selected reference time units to demonstrate a neural pathway from, for example, one or a plurality of input neurons through intermediate destination neurons to an output neuron in three-dimensional space.
University Of Tennessee Research Foundation


new patent Bk channel-modulating peptides and their use
The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance ca2+ activated k+ (bk) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to the brain of a subject through the blood-brain barrier.. .
Board Of Regents, The University Of Texas System


new patent Method, system and non-invasive neurostimulation therapy of the brain
The present invention is a portable non-invasive system, apparatus and method for performing light therapy or photobiomodulation upon the brain tissues through the skull and/or nostrils of a living mammalian subject for the medical purpose of stimulating the brain in-vivo. The present invention utilizes the transcranial and/or intranasal pathways as points of anatomic access and follows established principles for the conceptual approach that irradiation of the brain tissue with low level light energy of certain fixed parameters would achieve major therapeutic effects in-vivo..

new patent Optogenetic control of endothelial cells
The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth..
Massachusetts Institute Of Technology


new patent Neurostimulation using ac and/or dc stimulation pulses
Neurostimulation is performed using electrical ac and/or dc stimulation pulses. brain and/or spinal cord stimulation of a patient is achieved using an implanted neurostimulation device.
Precisis Ag


new patent Catheter and guide tube for intracerebral application
A catheter for use in neurosurgery, and a method of positioning neurosurgical apparatus. The catheter has a fine tube arranged for insertion into the brain parenchyma of a patient with an external diameter of not more than 1.0 mm.
Renishaw (ireland) Limited


new patent Engineered receptor/ligand system for delivery of therapeutic agents
Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent to a subject utilizing an engineered receptor-ligand system, such as an engineered dockerin-cohesin system. As described herein, previously-developed targeted delivery systems for delivering therapeutic and diagnostic agents to a tissue of interest have drawbacks that have not been addressed to date.
University Of Florida Research Foundation, Inc.


new patent Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound
The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical composition according to the present invention contains a combination of an aldehyde inhibitor and a biguanide-based compound, which can effectively inhibit the growth of cancer stem cells such as neurospheres and can also inhibit the proliferation, invasion and metastasis of cancer cells, thereby preventing and/or treating cancer such as brain cancer..
National Cancer Center


new patent Robot for minimally invasive neurosurgery
A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate.
Technion Research & Development Foundation Ltd.


new patent

Early diagnosis and treatment of alzheimer disease and mild cognitive impairment

Methods, systems and devices for detecting and treating cognitive impairment conditions by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the cognitive impairment condition.. .
Nibs Neuroscience Technologies Ltd.

new patent

System and method to assess risk of changes to brain white matter based on head impact dose equivalent number

A system to assess risk of changes to brain white matter includes a sensor system adapted to measure an energy of each impact to an individual belonging to a sub-population that causes a repetitive head impact (rhi). A head impact dose equivalent number (hiden) process calculates a hiden for a most recent rhi event based on the energy of the most recent rhi event, a time of the most recent rhi, and all previously recorded rhi events available in a non-volatile memory.
University Of Rochester

new patent

Wearable physiological monitoring device

The present invention discloses a wearable physiological monitoring device for providing brain activity information and deciding a breathing guiding signal in a neurofeedback section, for being a basis for a user to perform a self-regulation about brain function. The device includes a wearable structure for mounting plural eeg electrodes and/or optical sensor on the head and/or an ear of the user so as to obtain information about brain activity and respiratory behavior..

Hearing assistance system comprising an eeg-recording and analysis system

A hearing assistance system comprises an input unit for providing electric input sound signals ui, each representing sound signals ui from a multitude nu of sound sources si, an electroencephalography (eeg) system for recording activity of the auditory system of the user's brain and providing a multitude ny of eeg signals yj, and a source selection processing unit receiving said electric input sound signals ui and said eeg signals yj, and in dependence thereof configured to provide a source selection signal Ŝx indicative of the sound source sx that the user currently pays attention to using a selective algorithm that determines a sparse model to select the most relevant eeg electrodes and time intervals based on minimizing a cost function measuring the correlation between the individual sound sources and the eeg signals, and to determine the source selection signal Ŝx based on the cost functions obtained for said multitude of sound sources.. .
Oticon A/s

Methods for improved measurements of brain volume and changes in brain volume

Methods of the disclosure may include obtaining a first set of medical images at a first time point and a second set of medical images at a second time point, each set including at least two medical images. First and second algorithms may be used to calculate, respectively, first and third brain volume (bv) values at the first time point based on two or more images from the first set of medical images and second and fourth bv values at the second time point based on two or more images from the second set of medical images.
Biogen Ma Inc.

Method and system for providing a brain computer interface

A method for providing a brain computer interface that includes detecting a neural signal of a user in response to a calibration session having a time-locked component and a spontaneous component; generating a user-specific calibration model based on the neural signal; prompting the user to undergo a verification session, the verification session having a time-locked component and a spontaneous component; detecting a neural signal contemporaneously with delivery of the verification session; generating an output of the user-specific calibration model from the neural signal; based upon a comparison operation between processed outputs, determining an authentication status of the user; and performing an authenticated action.. .
Arctop, Inc.

Methods and apparatuses for determining head movement

The present application discloses various methods and apparatuses for determining a head movement, wherein a method for determining a head movement disclosed comprises: acquiring, in response to a head movement of a human body, brain electricity detection information of a human body; and determining the head movement corresponding to the brain electricity detection information. The present application provides a new solution for head movement recognition, by which accuracy of head movement recognition is improved..
Beijing Zhigu Rui Tuo Tech Co., Ltd.

Use of an anti-alpha-synuclein antibody to diagnose an elevated level of alpha-synuclein in the brain

This disclosure relates to the use of anti-α-synuclein antibody to diagnose an elevated level of α-synuclein in the brain. Specifically, the disclosure relates to the method of assessing the levels of α-synuclein in a blood plasma or csf following administration to the test subject of an anti-α-synuclein antibody or antigen-binding fragment thereof, which can bind α-synuclein with sufficient activity to alter the net efflux of α-synuclein from brain to blood, or from brain to csf..
Biogen International Neuroscience Gmbh

Monoclonal antibody for the diagnosis, treatment and/or prevention of brain tumors and brain lesions

The invention relates to the use of the monoclonal antibody nilo1 for the diagnosis, treatment and/or prevention of brain tumors and lesions. Particularly, the invention relates to methods for the diagnosis of brain tumors and brain lesions in which cells marked with said antibody, or with immunologically active fragments thereof, are detected.
Consejo Superior De Investigaciones Cientificas (csic)

Editing profiling of pde8a pre -mrna: use as specific biomarker of adars activities in human tissues to diagnose and to predict and assess therapeutic efficacy and/or efficiency or potential drug side effects

The present invention relates to the use of the editing profile of pde8a pre-mrna as a specific bio marker of adars activities in evolved primate, particularly in human tissues. The present invention also relates to an in vitro method for predicting in human an alteration of the mechanism of the adars catalysed pre-mrna editing of target genes, by analysing the pde8a pre-mrna editing profile in a peripheral tissue sample containing cells expressing said pde8a pre-mrna, such as blood sample.
Alcediag

Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof

The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hes-mscs are characterized at least in part by the low level of expression of il-6.
Imstem Biotechnology, Inc.

A direct conversion human fibroblasts into neural stem cells using small molecules

The present invention relates to a method of converting human fibroblasts into neural stem cells, and more particularly, to a method of directly converting human fibroblasts into neural stem cells using only a combination of small-molecule compounds without any introduction of a foreign gene, and to the use of the neural stem cells. The method of directly converting human fibroblasts into neural stem cells using only small-molecule compounds without any introduction of a foreign gene makes it possible to obtain genetically stable neural stem cells in an amount sufficient for use in cell therapy by deriving them from human fibroblasts.
Korea University Research And Business Foundation

Antibodies against p97 and conjugates thereof

Provided are conjugates between (a) an antibody or antigen-binding fragment thereof that binds to p97 (melanotransferrin; mtf) and (b) an agent of interest, and related compositions and methods, for example, to improve pharmacokinetics and/or delivery of the agent of interest across the blood-brain barrier (bbb) and into tissues of the central nervous system (cns).. .
Bioasis Technologies, Inc.

Antibody molecules and peptide delivery systems for use in alzheimer's disease and related disorders

The present invention relates to antibody molecules and peptide delivery systems for use in the treatment and management of alzheimer's disease and related disorders. In particular, the antibody molecules preferentially bind oligomeric forms of beta-amyloid peptide, in single domain format, and the peptide delivery systems facilitate specific transport of such antibody molecules, as well as other cargo molecules, across the blood-brain barrier.
Technophage, InvestigaÇÃo E Desenvolvimento Em Biotecnologia, S.a.

Fusion protein comprising leptin and methods for producing and using the same

The present invention provides fusion proteins comprising leptin and a second protein. The presence of the second protein provides increased biological activity and/or increased half-life in vivo.
Askgene Pharma, Inc.

Diagnosis and treatment of chronic pain

Methods, systems and devices for treating chronic pain by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity and/or excitability of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the chronic pain.. .
Nibs Neuroscience Technologies Ltd.

Prolonged anti-diabetic effect of fibroblast growth factor 1 (fgf1)

Disclosed are compositions and methods for inducing sustained diabetes remission by single administration of fgf1 to the brain. The composition and methods described herein result in basal glucose clearance by using a dosage of fgf1 that is lower than that needed for systemic efficacy and is devoid of the risk of hypoglycemia and changes in body weight, food intake, hepatic glucose production, insulin secretion or insulin sensitivity..
University Of Washington

Cholinergic enhancers with improved blood-brain barrier permeability for the treatment of diseases accompanied by cognitive impairment

A method for the treatment of a neurodegenerative, psychiatric or neurological disease associated with a cholinergic deficit comprising administering gln-1062 or a pharmaceutically acceptable salt thereof by nasal administration to a patient in need thereof.. .
Neurodyn Life Sciences Inc.

System of joint brain tumor and cortex reconstruction

System for performing fully automatic brain tumor and tumor-aware cortex reconstructions upon receiving multi-modal mri data (t1, t1c, t2, t2-flair). The system outputs imaging which delineates distinctions between tumors (including tumor edema, and tumor active core), from white matter and gray matter surfaces.
Sony Corporation

Method to exercise eyes, hands and feet coordination

As depicted in figs. 1-7, the eye detects that the foot is slower than the hand and the information is sent immediately from the eye to the brain.

Method for detecting hematoma, portable detection and discrimination device and related systems and apparatuses

Featured are methods, apparatus and devices for detecting a hematoma in tissue of a patient. In one aspect, such a method includes emitting near infrared light continuously into the tissue from a non-stationary near infrared light emitter and continuously monitoring the tissue using a non-stationary probe so as to continuously detect reflected light.
The Henry M. Jackson Foundation For The Advancemen Of Military Medicine, Inc.

Dual eeg non-contact monitor with personal eeg monitor for concurrent brain monitoring and communication

Aspects of the disclosure can provide a method and device for detecting eeg signals of a first person in proximity to the device. The device can include a non-contact eeg directional circuit having non-contact sensors, the non-contact eeg directional circuit being configured to detect the eeg signals produced by a brain of the first person without making contact with the first person.
Freer Logic, Inc.

Immunotherapy for clearing pathological tau conformers

The present invention relates to methods of treating and preventing alzheimer's disease or other tauopathies in a subject by administering a tau protein, its immunogenic epitopes, or antibodies recognizing the tau protein or its immunogenic epitopes under conditions effective to treat or prevent alzheimer's disease of other tauopathies. Also disclosed are methods of promoting clearance of from the brain of the subject and of slowing progression of tangle-related behavioral phenotype in a subject..
New York University

Device for non-invasive neuro-stimulation by means of multichannel bursts

A device is provided for the stimulation of neurons that includes a non-invasive stimulation unit to generate stimuli in multiple stimulation channels, where the stimulation unit stimulates a neuron population in the brain and/or spinal cord of a patient in different locations for each of the stimulation channels. Moreover, the device includes a control unit that controls the stimulation unit to generate repetitive bursts in each of the stimulation channels, where each of the bursts includes multiple stimuli and is designed so that they do not reset the phase of the neuronal activity of the respective stimulated neurons..
Forschungszentrum Juelich Gmbh

Blood brain barrier receptor antibodies and methods of use

The present invention relates to antibodies that bind to receptors expressed on the blood brain barrier and methods of using the same.. .
Genentech, Inc.

Methods and compositions for treating brain diseases

The present disclosure provides methods for treating or preventing huntington's disease (hd) in a subject in need thereof, comprising administering a therapeutic agent that activates mtorc 1 function and/or increases ras homolog enriched in striatum (rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment, and methods for modulating mhtt-associated metabolic phenotypes and/or reversal of striatal atrophy by administering a therapeutic agent that activates mtorc1 function and/or increases ras homolog enriched in striatum (rhes) level in the subject's brain as compared to the function or level in the subject prior to treatment.. .
University Of Iowa Research Foundation

Method for treatment of internal disorders via activation of dermatomal nervous receptors

A system and method for treating neural lesions is disclosed. The inventive method comprises determining the location of a neural lesion in a patient and applying a selected modality to a dermatomal region on the patient to compensate for the existence of the neural lesion.

Image processing apparatus, image processing method, and program

An image processing device includes: an image data acquisition unit for acquiring spect image data of a brain; a brain-region roi definition unit for defining a brain-region roi in the spect image; a striatum roi definition unit for defining a striatum roi in the spect image; and a threshold determination unit for, based on counts in the spect image's background which is the brain-region roi except the striatum roi, determining a threshold for distinguishing ventricles and sulci in the spect image; a region distinction unit for distinguishing between a region whose number of counts is smaller than or equal to the threshold and a region whose number of counts is larger than the threshold.. .
Nihon Medi-physics Co., Ltd.

Devices which prompt diverse brain states to upgrade brain performance

An electronic device that includes an electronic calendar containing scheduled events, the device further including a) software that matches an event with an optimal brain state, and b) means for convening to the user of the device such optimal brain state when the calendar indicates that the event is imminent or has arrived.. .

Insertion of medical devices through non-orthogonal and orthogonal trajectories within the cranium and methods of using

The invention comprises an elongated device adapted for insertion, including self-insertion, through the body, especially the skull. The device has at least one effector or sensor and is configured to permit implantation of multiple functional components through a single entry site into the skull by directing the components at different angles.

Prediction of preictal state and seizure onset zones based on high frequency oscillations

A seizure preemption system including electrodes for recording simultaneous electroencephalographic (eeg) signals from a subject, a controller electrically coupled to the electrodes, and a neuromodulator electrically coupled to the controller. The controller is configured to sample the simultaneous eeg signals, identify high frequency oscillation (hfo) events in each eeg signal, and extract one or more features from each eeg signal to yield hfo profiles for the hfos recorded from each eeg signal.
Seton Healthcare Family

Vibrating footwear device and entertainment system for use therewith

Methods of enhancing a sensory experience to simulate a live event are provided. One includes providing an audible signal representing sound information; generating a vibration signal based on the audible signal and enhanced information that would be present at the live event; and providing the vibration signal to at least one vibration device for stimulating nerve receptors in a foot area, the vibration signal synchronized with the audible signal to produce a perception in the brain of being present at the live event.
Sonicsensory, Inc.

System, method, and recording medium for detecting and leveraging brain waves present in a user's state of flow to control digital and physical notifications

A notification control method, system, and non-transitory computer readable medium, include a state of flow detecting circuit configured to detect a state of flow of brain waves of a user from user data, a notification priority setting circuit configured to set a notification priority setting by ranking a type of a notification to be delivered to a user device according to an importance of a message associated with the notification, and a notification control circuit configured to control the notification to be output on the user device at an allowable time based on a rank of the notification priority setting being higher than a rank of the state of flow of the user.. .
International Business Machines Corporation

Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration

The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration.
The Johns Hopkins University

Brain in vitro models, devices, systems, and methods of use thereof

Exemplary embodiments provide in vitro brain models, such as in vitro models of a neurovascular unit or a functionally connected trineural pathway, and systems, devices and methods of use thereof. The present invention provides in vitro brain models, systems, devices and methods that mimic in vivo conditions to, for example, determine the effect of a test compound, such as a drug candidate or a toxin, on various biological responses, such as for example, cell viability, cell growth, migration, differentiation and maintenance of cell phenotype, metabolic activity, structural remodeling and tissue level pre-stress, a neural activity, such as an electrophysiological activity..
President And Fellows Of Harvard College

3.alpha.-ethynyl, 3.beta.-hydroxy-5.alpha.-pregnan-20-oxime for use in the treatment of cns disorders

The invention relates to 3α-ethynyl, 3β-hydroxy, 5α-pregnan-20-oxime or a pharmaceutically acceptable salt thereof, which compounds and/or salts are useful as modulators of the mammal brain excitability via the gamma-5 aminobutyric acid receptor-chloride ionophore (gabaa-r) complex and in the treatment of disorders such as hepatic encephalopathy, down's syndrome and alzheimer's disease.. .
Umecrine Cognition Ab

Cognitive function within a human brain

Methods and apparatus for improving cognitive function within a human. The invention utilizes an implanted device, such as an implantable signal generator or an implantable pump, to affect tissue elements within a papez circuit of the human brain as well as tissue upstream or downstream from the papez circuit.
Functional Neuromodulation Inc.

Method and device for enhancing memory consolidation

The present invention relates to methods and devices to consolidate memory and/or cognitive functions by monitoring brain rhythms and delivering a stimulus at an appropriate stage of sleep cycle.. .
Inserm (institut National De La SantÉ Et De La Recherche MÉdicale)

Device and effective non-invasive neurostimulation by means of varying stimulus sequences

A device is provided for stimulating neurons that includes a non-invasive stimulation unit that generates stimuli in multiple stimulation channels. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation channels in different locations.
Forschungszentrum Juelich Gmbh

System for active skull replacement for brain interface and using the same

An active skull replacement system including an implant having an area a, an upper surface, and a bottom surface, adapted to be implanted at least in part into a skull of a subject so to substitute a portion of the skull, the bottom surface arranged to face at least in part a cranial cavity, and having a first wireless bidirectional data communication device, a device operably connected to the bottom surface of the implant, the device adapted to at least one of stimulate a physiological response and record a physiological parameter of the subject, and an external reader adapted to be placed on the scalp of the subject and including a second wireless bidirectional data communication device configured to communicate with the first wireless bidirectional data communication device of the implant to operate the device, wherein the external reader and the implant are fixed and aligned among each other through a magnetic device.. .
Ecole Polytechnique Federale De Lausanne (epfl)

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Jenkem Technology Co., Ltd. (tianjin)

Methods and compositions for reducing growth, migration and invasiveness of brain cancer stem cells and improving survival of patients with brain tumors

The described invention relates to a pharmaceutical composition comprising a therapeutically effect amount of a therapeutic agent, wherein the therapeutic agent is effective (1) to reduce tumor growth, migration, invasion or a combination and (2) improve subject survival relative to a control. The described invention also relates to a method of treating a subject with a tumor, the method comprising: (1) providing a pharmaceutical composition; and (2) administering the pharmaceutical composition, wherein the composition comprises a therapeutically effective amount of a therapeutic agent which is effective to reduce tumor growth, migration, invasion or a combination.
Hyperstem, Sa

Methods for increasing serum igf-1 in an animal

Provided herein are methods for increasing the concentration of insulin-like growth factor (igf) in the serum of a subject. In one embodiment, the method includes administering active igf-1 to a subject, wherein the concentration of igf in the serum of the subject is increased.
Puretein Bioscience Llc.

Device for measuring the brain activity signals of an individual

Disclosed is a device suitable for measuring the brain activity signals of an individual, the device being intended to be placed on the head of the individual and having a structure intended to carry sensors, the structure allowing the position of the sensors to be adjusted. The structure of the device has: a deformable central support, which is able to adapt to the curvature of the head and is intended to be positioned along the head, preferably on the median plane of the cranium; flexible guides, which extend laterally with respect to the central support and are spaced apart from each other; sensor supports, which are rigidly connected and fixed to the flexible guides, in adjustable positions along the flexible guides; and a system for tightening the flexible guides..
Etablissements Malterre Sarl

Apparatus and detecting a state of a driver based on biometric signals of the driver

An apparatus and a method is provided for detecting biometric signals of a driver and classifying the driver into a normal state or a fatigued state based on the biometric signals. An apparatus may include: a biometric signal measuring part configured to measure the biometric signals including a blood flow rate of a brain of the driver using an electro-encephalography (eeg), an electro-cardiography (ecg), and a functional near-infrared spectroscopy (fnirs) of the driver; a biometric signal integral part configured to integrate the measured biometric signals, to extract characteristics of the respective biometric signals from the measured biometric signals and to then integrate the extracted characteristics, or to classify the extracted characteristics of the biometric signals and to then integrate the classified characteristics; and a driver state detecting part configured to detect the state of the driver based on the integrated biometric signals..
Gwangju Institute Of Science And Technology

Methods and kits for diagnosing, assessing or quantitating drug use, drug abuse and narcosis, internuclear ophthalmoplegia, attention deficit hyperactivity disorder (adhd), chronic traumatic encephalopathy, schizophrenia spectrum disorders and alcohol consumption

The invention provides methods for diagnosing, assessing or quantitating drug use, drug abuse or narcosis or for differentiating drug use, drug abuse or narcosis from brain injury in a subject by tracking eye movement of at least one eye of the subject, analyzing eye movement of at least one eye of the subject, comparing eye movement of at least one eye of the subject the normal or mean eye movement; and, optionally calculating a standard deviation or p value for eye movement of at least one eye of the subject as compared to the normal or mean eye movement.. .
New York University

Personal brain structure displaying device having intracranial electrodes and its displaying method

An electrode module is positioned inside an intracranial portion of a human head. Then, it captures brain images of the human head so multiples two dimensional (2d) cross-sectional images are obtained.
Chung Shan Medical University Hospital

Novel system and method to diagnose and predict different systemic disorders and mental states

The present invention relates a novel system and method to diagnose and predict systemic disorders including brain disorders and mental states in early stage and more accurately. More particularly, this invention relates to a novel method of eeg recording and processing through which multiple output data streams are taken together from a system like brain and the structure of their correlation matrix is studied through its eigenvector, eigendirection and eigenspaces and other signal processing techniques including compression sensing, wavelet transform, fast fourier transform etc..

Rehabilitation system using artificially intelligent horseback-riding hippotherapy and operating same

A rehabilitation system using an artificially intelligent horseback-riding apparatus for hippotherapy, the system comprising: an artificially intelligent horseback-riding apparatus which is ridable; a smartphone which can communicate with a cloud server and has installed an application for controlling the operation state of the artificially intelligent horseback-riding apparatus and operating the horseback-riding apparatus; a diagnostic device which is for diagnosing the state of a patient by means of a brain wave signal of the patient; an operating unit which is for operating the artificially intelligent horseback-riding apparatus; and a cloud server which is for storing, in the smartphone, treatment program and data, necessary for a patient treatment, and for transmitting same.. .

Mechanical-waves dissipating protective headgear apparatus

The present invention provides an apparatus to dissipate and attenuate mechanical waves which travel through a human brain upon blunt trauma. The apparatus comprises a pressurizable and ventable outer balloon shell encasing an inner hard shell.

Protective athletic helmet to reduce linear and rotational brain acceleration

A protective helmet includes an upper section and a lower section; each having inner and outer facing surfaces; a gap formed between the upper and lower sections; at least one connection member connecting the upper section to the lower section and maintaining the gap; the upper section being movable with respect to the lower section when an impact force is applied to the outside surface of the upper section; an inner shell securable to the inner facing surface of the lower section; the inner shell being adapted to receive a portion of the helmet user's head, whereby the head of the user will be spaced from the inner facing surface of the upper section when the portion of the user's head is received in the inner shell; and the inner shell substantially preventing the user's head from making contact with the inner facing surface of the upper section.. .

Parallelization techniques for variable selection and predictive models generation and its applications

Predictive regression models are widely used in different domains such as life sciences, healthcare, pharma etc. And variable selection, is employed as one of the key steps.
Tata Consultancy Services Limited

Human blood brain barrier model

An in vitro population of human brain endothelial cells (hbecs) expressing claudin-5, occludin, zo-1 and glut-1 and expressing one or more of fzd7, wnt7a, wnt7b, apcdd1, stra6 and zo-3 is provided. A blood brain barrier (bbb) comprising the hbecs and use of the bbb for analyzing permeability characteristics of a test agent are provided..
National Research Council Of Canada

Use of binding molecule specifically binding to precursor of brain-derived neurotrophic factor

Disclosed herein is use of a binding molecule which specifically binds to a precursor of brain-derived neurotrophic factor (probdnf). The binding molecule for probdnf, especially a monoclonal antibody against probdnf, can be used to prevent, mitigate or treat autoimmune diseases..
Shanghai Yile Biotechnology Co., Ltd.

Implantable device for optically stimulating the brain comprising a multi-channel catheter

An implantable device for optically stimulating a brain of a human being or animal, including: a multi-channel biocompatible catheter including a plurality of channels extending substantially parallel to each other relative to a longitudinal axis of the multi-channel catheter; a light guide, extending into one channel, for optically stimulating the brain, the multi-channel catheter acting as a sheath totally enveloping the light guide; a functional element, extending into another channel, to measure light injected into a surrounding medium at a distal end of the light guide and/or an element acting on the shape of the multi-channel catheter.. .
Commissariat A L'energie Atomique Et Aux Energies Alternatives

Systems and methods of combined tonic dbs and random dbs

The present disclosure provides systems and methods for combining tonic deep brain stimulation (dbs) and random dbs. A system includes a stimulation lead including a plurality of contacts, and an implantable pulse generator (ipg) communicatively coupled to the stimulation lead and configured to cause tonic stimulation to be delivered using one contact of the plurality of contacts, and cause random stimulation to be delivered using a subset of the remaining contacts of the plurality of contacts..
Pacesetter, Inc.

Compositions and methods for reduction of amyloid-beta load

The present invention relates to methods and compositions for modulating levels of amyloid-β peptide (aβ) exhibited by non-neuronal (i.e., peripheral) cells, fluids, or tissues. The invention also relates to modulation of ap levels via selective modulation (e.g., inhibition) of γ-secretase activity.
Modgene, Llc

Sleep profiling system with feature generation and auto-mapping

A method for profiling sleep of an individual is provided. The method includes defining a sleep feature space for the individual, measuring a brain wave for the individual during the individual's sleep, and mapping the sleep feature space in response to a comparison of the brain wave and a previous brain wave measurement used to define the sleep feature space.
Agency For Science, Technology And Research

Sleep monitoring cap

A sleep-monitoring cap includes interconnected electrodes embedded within a body of the sleep-monitoring cap. The interconnected electrodes are located at positions across a central transverse region, below and along a side of each eye, and on a rear mid-region of a person's head when wearing the sleep-monitoring cap.

Non-invasive estimating intra-cranial pressure (icp)

A non-invasive method of estimating intra-cranial pressure (icp). The method including the steps of: a.

Electrode placement and treatment system and use thereof

Certain aspects of the invention provide a system and a method for treating an epileptic condition or a tumor of the brain. In one embodiment, the method of treating the epileptic condition includes acquiring inter- and post-ictal imaging profiles and from the brain of the patient and determining an ictal propagation pathway based on the profiles.
Rush University Medical Center

Computer display screen for concussion patients

Provided are display screens for electronic devices and methods for displaying content on electronic devices, that are particularly suitable for users who are suffering from or recovering from a concussion or mild traumatic brain injury (mtbi), migraine, or computer vision syndrome. Embodiments comprise a component that modifies at least one parameter of content that is displayed on the display screen, wherein the modified displayed content reduces, minimizes, or eliminates negative side effects of users.
Iris Technological Design Incorporated

Accelerated learning, entertainment and cognitive therapy using augmented reality comprising combined haptic, auditory, and visual stimulation

A plurality of first sensory cues are generated capable of being perceived by a user. Each first sensory cue of the plurality of first sensory cues is dependent on a position of at least one body member of a performer relative to a performance element of a performance object with which an event is performed.

Monotonous game-like task to promote effortless automatic recognition of sight words

System and methods are provided to promote effortless automatic recognition of common sight words. A subject performs a game-like task that generates novel non-verbal visual stimuli that triggers visual attention shifts that enhance foveal and parafoveal recognition of non-verbal and verbal stimuli laterally presented in the right or left visual field.
Brightstar Learning

Direct estimation of patient attributes based on mri brain atlases

The present invention is directed to a context-based image retrieval (cbir) system for disease estimation based on the multi-atlas framework, in which the demographic and diagnostic information of multiple atlases are weighted and fused to generate an estimated diagnosis, on a structure-by-structure basis. The present invention demonstrates high accuracy in age estimation, as well as diagnostic estimation in alzheimer's disease.
The Johns Hopkins University

System, method, and devices for reducing concussive traumatic brain injuries

A system for reducing traumatic brain injuries in players on a sports field includes a number of transmitters worn by at least some of the players; a plurality of sensors configured for placement on or near the sports field for receiving signals transmitted from the transmitters as the players move about on the field; a head-stabilizing component worn by at least one of the players that inhibits relative motion of the player's head when activated; and a processing element coupled with the sensors and in communication with the head-stabilizing component. The processing element determines locations of the players based on the signals transmitted from the transmitters worn by the players, determines if the players are likely to impact one another or an object on the field based on the locations of the players, and transmits an activating signal to the head-stabilizing component to inhibit relative motion of the player's head if the processing element determines the player is likely to impact another player or an object on the sports field..

Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same

Activity-dependent gene pairs as therapeutic targets and methods and devices to identify the same are provided. The methods and devices allow transcriptome-wide analysis of regulatory long non-coding rnas (incrnas), matched with differentially expressed protein-coding genes (mrnas) and/or with other incrnas.
Wayne State University

Thienopyrimidines and uses thereof

Described herein are thienopyrimidine compounds of formula (i), and pharmaceutically acceptable salts, and pharmaceutical compositions thereof. Also provided are methods and kits involving the thienopyrimidine compounds or compositions for treating or preventing proliferative diseases such as cancers (e.g., brain tumors such as dipgs) in a subject.
Memorial Sloan-kettering Cancer Center

Compositions, methods, and systems for the synthesis and use of imaging agents

The present invention generally relates to novel synthetic methods, systems, kits, salts, and precursors useful in medical imaging. In some embodiments, the present invention provides compositions comprising an imaging agent precursor, which may be formed using the synthetic methods described herein.
Lantheus Medical Imaging, Inc.

Frontal airbag assemblies for reducing rotational velocity of a head of an occupant

Airbag assemblies are disclosed that can reduce rotational velocity of an occupant's head during a collision event and thereby mitigate traumatic brain injury/head injury to an occupant. An airbag includes a pair of lobes or protrusions to deploy and extend from the rear face of the airbag on either side of the occupant's head to limit rotation of the head.
Autoliv Asp, Inc.

Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair

Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via transforming growth factor beta (tgf-β), bone morphogenetic protein (bmp), glycogen synthase kinase 3 (gsk-3), and γ-secretase/notch pathways.
The Penn State Research Foundation

Compositions containing defined caffeine and theobromine levels with enhanced cognitive properties

The invention includes compositions and methods for improving cognitive function or reducing the anxiety effects of caffeine cravings. Caffeine and theobromine are naturally occurring and are both present in cocoa-derived food products or ingredients.
The Hershey Company

Procedure and a portable diagnosis of seizures

There are disclosed systems and methods for seizure diagnosis by video electroencephalography (video-eeg). There is disclosed a fully automated, portable, point-of-care diagnostic video eeg device.
Mocxa, Llc

Brain activity prediction

A method for estimating a brain activity response following a stimulus of a person comprises the steps: providing a usage data set of the person from a personal device used by said person, wherein at least one usage attribute is associated to said usage data set, wherein attribute data is associated to each of the at least one usage attribute, providing a computational inference model, generated from a plurality of brain activity data sets and a plurality of usage data sets, wherein each brain activity data set comprises data derived from a brain activity response following a sensory stimulus, submitting the attribute data of each of the at least one usage attributes to said computational inference model, estimating a brain activity response following a sensory stimulus of said person by evaluating said computational inference model for the submitted attribute data. The method is useful to determine, for example the influence of intensive touch pad usage (of a smartphone) on somatosensory evoked potentials..
University Of Fribourg

Prevention and treatment of synucleinopathic and amyloidogenic disease

The invention provides improved agents and methods for treatment of diseases associated with synucleinopathic diseases, including lewy bodies of alpha-synuclein in the brain of a patient. Such methods entail administering agents that induce a beneficial immunogenic response against the lewy body.
The Regents Of The University Of California

N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and their therapeutic use

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (copd); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as behçet's disease.
Pimco 2664 Limited

Histone deacetylase inhibitors

Provided herein are brain penetrant histone deacetylase (hdac) inhibitors useful for treating diseases or disorders associated with hdac. An exemplary hdac inhibitor provided herein exhibits a brain-to-plasma ratio of 20:1.
The General Hospital Corporation

Blood brain barrier-penetrating oximes for cholinesterase reactivation

The invention describes pharmaceutical agents capable of crossing the blood brain barrier to protect against organophosphate pesticides and nerve agents or other electrophiles by reactivating inhibited cholinesterase (i.e., acetylcholinesterase and butyrylcholinesterase) and other proteins in the peripheral and central nervous system.. .
Human Biomolecular Research Foundation

Inhibitors of lysine gingipain

The present invention relates generally to therapeutics targeting the bacterium porphyromonas gingivalis, including its protease lysine gingipain (kgp), and their use for the treatment of disorders associated with p. Gingivalis infection, including brain disorders such as alzheimer's disease.
Cortexyme, Inc.

Hippocampal drug delivery devices and methods

Drug delivery devices and methods are disclosed herein. In some embodiments, a drug can be delivered into a brain ventricle of a subject, where it can diffuse, flow, or otherwise travel across the ependyma and into the hippocampus.
Alcyone Lifesciences, Inc.

Tfr selective binding compounds and related methods

The present invention relates to peptides that bind with high specificity and which functionally interact with the transferrin receptor (“tfr”) and which may be used in making molecular vehicles that carry biomolecules across membranes, including, e.g., across the blood brain barrier or the gastrointestinal tract. Tfr specific binding moieties may also be used alone or as components in specific molecules that target the transferrin/transferrin receptor transport system.
Ossianix, Inc.

Methods and compositions for treating brain diseases

The present disclosure provides targeting peptides and vectors containing a sequence that encodes targeting peptides that deliver agents to the brain.. .
University Of Iowa Research Foundation

Soybeam seed extract, producing the same and uses thereof

The invention relates to a soybean seed extract, method for producing the same and uses of the extract of soybean seeds in promoting wound healing, promoting neuron cell proliferation and/or treating brain diseases and/or neurodegenerative diseases, treating breast cancer, reducing side effects of interfering with dna and/or rna replication drugs and/or enhancing pharmaceutical effects of interfering with dna and/or rna replication drugs.. .
Charsire Biotechnology Corp.

Combination therapy for cancer

A method of treating brain cancer in an immune-competent human patient by administering ternozolornide to the immune-competent human patient, the improvement comprising administering to said immune-competent human patient a viral vector.. .
Gliotherapy Limited

Methods and compositions for modulating serotonin levels

The present application in one aspect provides methods and compositions that are fine-tuned to modulate brain and peripheral serotonin levels, which in turn would lead to prevention and treatment of various diseases associated with a reduced level of brain serotonin. In another aspect, there are provided methods of assessing the peripheral or placenta level of serotonin and associated risks based on the peripheral placental level of tph1..
Children's Hospital & Research Center At Oakland

Preparation and use of ketamine derivatives and ketamine modifiers in the treatment of pain

Disclosed herein are ketamine derivatives that have been modified to reduce or prevent transference across the blood brain barrier. The ketamine derivatives will allow the reduction of pain in the patients without complications associated with psychotropic effects typically associated with unmodified ketamine..

Methods of intravenous administration of glyburide

The present disclosure is drawn to a method of treating a patient in need of treatment, comprising identifying a patient in need of treatment for stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, ventricular arrhythmias, ischemic injury, or hypoxia/ischemia; administering a bolus of glyburide to the patient; and administering a continuous infusion of glyburide to the patient at from about 15 μg/hr and about 300 μg/hr, wherein the continuous infusion glyburide is administered for a period of time more than about 20 hours.. .
Biogen Chesapeake Llc

Neuro attack prevention system, method, and apparatus

A portable biomedical device for detecting ischemic stroke in the brain. Its unique capability of enabling portability and compactness and being able to accommodate software that can resolve blood flow velocity measurements enable us to leverage multi-modality system benefits while using simple single modality instrumentation.
S Square Detect Medical Devices

Diagnosis of brain and spinal cord injury by bulbocavernosus reflex measurement

A system and method is disclosed for measuring muscle reflexes (e.g., a bulbocavernosus reflex) as a tool for identifying/diagnosing dysfunctions (e.g., spinal cord abnormalities, bladder voiding dysfunction, and sexual organ dysfunction) non-invasively by using mechanical stimulation. The system and method includes a probe having a predetermined patient contacting portion, wherein when the contacting portion is moved into contact with a particular area of the patient (e.g., the patient's genitals), the contact induces a muscle reflex.
Uroval, Inc.

Systems and methods for analyzing brain activity and applications thereof

In some embodiments, the present invention provides an exemplary inventive system that includes: an apparatus to record: individual's brain electrical activity, a physiological parameter of the individual, and iii) an environmental parameter; a computer processor configured to perform: obtaining a recording of the electrical signal data; projecting the obtained recording of electrical signal data onto a pre-determined ordering of a denoised optimal set wavelet packet atoms to obtain a set of projections; normalizing the particular set of projections of the individual using a pre-determined set of normalization factors to form a set of normalized projections; determining a personalized mental state of the individual by assigning a brain state; determining a relationship between: the physiological parameter, the environmental parameter, and the personalized mental state; generating an output, including: a visual indication, representative of the personalized mental state, and) a feedback output configured to affect the personalized mental state of the individual.. .
Neurosteer Ltd.

Brain activity monitoring, supporting mental state development and training

Embodiments of the present invention are directed towards a system and method for determining an extent of concussion experienced by a user. The method includes receiving, by a computing device, electroencephalogram (eeg) data related to the user from an external device associated with the user.

Brain-machine interface based on photonic neural probe arrays

Method and apparatus for illuminating and imaging tissue is provided. In one version, the method includes illuminating a volume of a tissue with photons from a three-dimensional array of optical emitters inserted into the tissue.
California Institute Of Technology

Personalization of auditory stimulus

Technology presented herein increases a user's enjoyment of sound by personalizing an audio signal so that the user perceives the audio signal as if the user had ideal hearing and/or desired hearing. In one embodiment, headphones on a user's head include a sensor and a speaker.
Nura Holdings Pty Ltd

Apparatus and visualizing tissue macro- and microstructure for pathology evaluation in magnetic resonance imaging

A method improves a detection of a brain tissue pathology in magnetic resonance (mr) images of a patient. The method includes acquiring multiple mr imaging data for creating four different contrast maps of a patient brain.
Centre Hospitalier Universitaire Vaudois

Method and device for displaying predicted volume of influence

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (dbs) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data.
The Cleveland Clinic Foundation

Use of striatal connectivity patterns for evaluating antipsychotic agents

A method of predicting the response of a subject to an antipsychotic agent is described. The method includes obtaining functional mri (fmri) scan data of the brain of the subject, modifying the scan data using a standardizing algorithm to provide modified scan data, calculating the value of a plurality of striatal connectivity dyads from the modified scan data using an extraction algorithm, calculating a combined score from the values of the striatal connectivity dyads using a combining algorithm; and comparing the combined score to a classifier value to determine if the subject is a responder or a non-responder.
The Feinstein Institute For Medical Research

Diagnosing and monitoring cns malignancies using microrna

The use of specific micrornas (mirnas) present in csf as biomarkers for particular brain malignancies and disease activity.. .
The Regents Of The University Of California

3,3 disubstituted 19-nor pregnane compounds, compositions, and uses thereof

Where r1, r2, r3, r3′, r4, r6a, r6a, r11a, and r11b are as defined herein. Compounds of the present invention are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, insomnia, anxiety, depression, traumatic brain injury (tbi), stress, and epilepsy..

Noble gas neuroprotection and neuroregeneration from treatment related neurotoxicity

Disclosed are means of inducing neuroregeneration and/or neuroprotection in patients with damage to the nervous system. In one embodiment, noble gas containing compositions are administered to a patient suffering from a neurological injury, said therapy is administered alone, or in combination with other therapies useful in the induction of neuronal protection/stimulation of neurogenesis.
Noblis Therapeutics, Inc.

Magnetic field stimulation

A magnetic coil system featuring a multi-layer structure, a spherical shape, or both allows for efficient generation of a gradient magnetic field that induces an electric field in air in a region proximate to the coil. By subjecting at least a portion of a person's brain to the induced electric field various psychiatric disorders can be treated..
The Mclean Hospital Corporation

Method and a system for optimizing the configuration of multisite transcranial current stimulation and a computer-readable medium

A system and a method for optimizing the configuration of multisite transcranial current stimulation, including providing an electric field characteristic target map on the brain's cortex, the target map including multiple cortical targets, the multiple cortical targets are localized and/or continuously varying and spatially extended, providing a weight map on the cortical surface prioritizing the important of areas in the target map for the purposes of optimization; and calculating, based on the target and weight maps, optimal currents and optimal locations for a plurality of electrodes intended for providing transcranial current stimulation to globally stimulate at once the multiple cortical targets with excitatory, inhibitory or neutral stimulation.. .
Beth Israel Deaconess Medical Center

Device and stimulating slow brain waves

Disclosed is a self-contained device for stimulating slow brain waves, capable of being worn by a person, in particular during a period of time when the person is sleeping. The device includes a supporting element, capable of surrounding the head of a person, and on which electrodes are mounted in contact with the person in order to acquire a measurement signal that represents a physiological electrical signal of the person; an acoustic transducer for emitting an acoustic signal stimulating the inner ear of the person; and on-board conditioning and control electronics for, in flexible real time, receiving the measurement signal and controlling the emission of an acoustic signal synchronized with a predefined slow brain wave time pattern..
Rythm

Composition, formulations and methods of making and using botanicals and natural compounds for the promotion of healthy brain aging

The present disclosure provides compositions and formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults and for prevention or inhibition of age associated neurodegenerative changes resulting in cognitive, memory and executive dysfunction including modulation of the age related predisposition to mild cognitive impairment, alzheimer's disease, hormonal and other dementia related conditions. The present disclosure also provides methods of using the compositions and formulations in treating and preventing neurodegenerative changes resulting in cognitive, memory and executive dysfunction..
The Brain Health Project Llc

Compounds and methods for inhibiting nhe-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders

The present disclosure is directed to compounds and methods for the treatment of disorders associated with fluid retention or salt overload, such as heart failure (in particular, congestive heart failure), chronic kidney disease, end-stage renal disease, liver disease, and peroxisome proliferator-activated receptor (ppar) gamma agonist-induced fluid retention. The present disclosure is also directed to compounds and methods for the treatment of hypertension.
Ardelyx, Inc.

Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors

This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .
Glaxosmithkline Intellectual Property Development Limited

Compounds for use in the prevention or treatment of cancer

The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field.
Fujimoto Co. Ltd.

Methods for identifying responders to dopaminergic neuronal enhancing therapies for the treatment of elevated heart rate and metabolic or cardiovascular conditions

Methods for identifying responders to agents that increase brain dopaminergic neuronal activity for the treatment of metabolic and cardiovascular disease and for treating elevated heart rate and metabolic disease or dysglycemia in subjects with type 2 diabetes.. .
Veroscience Llc

Brain disease diagnosis assistance system, brain disease diagnosis assistance method, and program

A brain disease diagnosis assistance system acquires a plurality of learning data items, each including brain wave feature data including feature amounts of brain waves extracted from the brain waves and disease information attached to the brain wave feature data, the disease information indicating a state of a brain disease corresponding to the brain wave feature data and classifies the plurality of acquired learning data into a plurality of clusters. A classifier for classifying learning data into portions corresponding respectively to types of disease information is generated based on disease information attached to learning data in each classified cluster.
Ntt Data I Corporation

System and measuring physiologically relevant motion

A system for measuring and monitoring physiologically relevant motion of a subject includes at least a motion sensor to measure movement of the subject and produce a series of movement data representing the movement of the subject over a period of time. The system also includes at least a biometric sensor to simultaneously measure biometrics of the subject and produce a series of biometric values of the subject over the period of time.
Rutgers, The State University Of New Jersey

Systems and methods for determining neurovascular reactivity to brain stimulation

System and methods for stimulating the neurovascular system of the cerebral tissue through optimally placed devices, while simultaneously measuring the evoked neuronal and hemodynamic responses, also using optimally placed devices, is disclosed. Systems and methods for iteratively stimulating the neurovascular system and recording neuronal and hemodynamic responses are also disclosed.
Neurotrix Llc

Similarity evaluation method using brain waves, evaluation device, evaluation system, and program

Provided are a method, a device, a system, and a program for evaluating similarity of brain activity with respect to an object to be evaluated, using data obtained by a simple measurement of brain waves. Brain wave data related to cognitive processing with respect to a plurality of sensory stimuli are dimensionally compressed, and a distribution of the object to be evaluated is displayed on a two-dimensional plane or three-dimensionally.
National Institute Of Advanced Industrial Science And Technology

Hybrid spectroscopy imaging system for intraoperative epileptic cortex detection

Methods and systems that detect and differentiate epileptogenic from eloquent and normal cortices are provided. A method for identifying epileptogenic cortices in a brain may include detecting areas in the brain that are undergoing cerebral blood volume low frequency oscillations, detecting areas in the brain that are undergoing blood oxygenation low frequency oscillations; mapping clusters of the brain in which the cerebral blood volume low frequency oscillations are negatively correlated with the blood oxygenation low frequency oscillations, and analyzing the time based relationship between the clusters of the brain that are undergoing negatively correlated low frequency oscillations to determine cause areas, which are areas of the brain that are causing negatively correlated low frequency oscillations to occur elsewhere..
The Florida International University Board Of Trustees

Interactive brain trainer

A brain training system and method are provided that incorporates a first phase and a second phase of brain training. The first phase is designed to increase attention by requiring the completion of an attention-based activity or task.

Phantom for quality assurance of magnetic resonance imaging and computed tomography for multi-artifact correction

The present invention relates to a phantom for quality assurance of magnetic resonance imaging (mri) and computed tomography (ct) for multi-artifact correction. An aspect of the present invention provides a phantom capable of simultaneously evaluating performance of magnetic resonance imaging (mri) and computed tomography (ct), the phantom including: a first hemispheric container; and a second hemispheric container which has the same structure and the same size as the first container, in which the first container and the second container are connected by being in direct contact with each other so as to form a symmetrical structure, each of the first container and the second container includes a teeth retainer into which a plurality of teeth mimics, which mimics teeth of a body, is inserted, and an insertion hole into which at least one bone mimic is inserted, and an interior of each of the first container and the second container is filled with at least one solution that mimics a brain metabolite..
The Catholic University Of Korea Industry-academic Cooperation Foundation

Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (bbb)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (ache) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.. .
Lawrence Livermore National Security, Llc

Malat-1, a non-coding rna, is a target for the regulation of learning and memory

Provided herein are methods for improving memory or cognitive function in a subject by administering a composition to the brain of the subject, where the composition comprises: i) a compound that increases expression of malat-1 long non-coding rna, ii) a malat-1 long-coding rna nucleic acid sequence, or iii) at least one malat-1 derived pirna nucleic acid sequence. Also provided herein are methods of screening candidate compounds for their ability to modulate the expression of malat-1 long non-coding rna in brain cells.
Ibis Biosciences, Inc.

Prodrugs of riluzole and their use

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process..
Rutgers, The State University Of New Jersey

Methods of neuromodulation using infraslow stimulation

Methods are provided to treat a neurological disorder in a patient by adjusting connectivity between network nodes in a brain of patient using electrical stimulation. Electrical stimulation including a carrier wave component is employed to adjust connectivity using infraslow frequencies of less than 1 hz..

Device for effective non-invasive desynchronizing neurostimulation

A device that suppresses a pathological synchronous and oscillatory neuron activity, and includes a non-invasive stimulation for stimulation, using stimuli, of neurons in the patient's brain and/or spinal cord, where those neurons are showing pathologically synchronous and oscillatory neuron activity, and the stimuli are designed to suppress are this activity when administered to the patient. Moreover, a measuring unit records measurement signals reflecting the neuron activity of the stimulated neurons and a control and analysis unit controls the stimulation unit to administer stimuli, check the success of stimulation based on the measurement, and, if the stimulation success is not sufficient, insert one or more stimulation breaks in the application of the stimuli or extend one or more stimulation breaks, where no stimuli that could suppress the pathological synchronous and oscillatory neuron activity are applied during the stimulation breaks..
Forschungszentrum Juelich Gmbh

Root cause cure and preventative measure for schizophrenia and other mental illness

A method and system for treating schizophrenia and other forms of mental illness, including: given a brain comprising neurons coupled by an axon including an inner core and an outer myelin sheath, and given one or more defects in the outer myelin sheath, repairing the one or more defects in the outer myelin sheath with one or more of a protein and a lipid such that the outer myelin sheath has a substantially constant electrical impedance for the transmission of data energy between the neurons and such that data energy is not undesirably reflected from the direction of a receiving neuron in the direction of a transmitting neuron within the axon.. .

Antioxidant composition containing extracellular polysaccharide produced using ceriporia lacerata as active ingredient

The present invention relates to an antioxidant composition containing an extracellular polysaccharide produced using ceriporia lacerata, or a mycelium culture of ceriporia lacerata comprising the same, or a dry powder or an extract thereof as an active ingredient. The composition can be used as an antioxidant for preventing or treating various diseases such as brain diseases such as stroke, parkinson's disease, etc., heart diseases, ischemia, arteriosclerosis, skin damage, inflammation, rheumatism, autoimmune diseases, etc.
Fugenbio Co., Ltd.

Composition comprising fut2-dependent oligosaccharides and lacto-n-neotetraose for use in promoting brain development and cognition

This invention relates to the use of a nutritional composition comprising fut2-dependent oligosaccharides for promoting brain growth and development in infants in the very early postnatal period. The nutritional composition comprises fut2-dependent oligosaccharides and lacto-n-neotetraose and is specifically for use in promoting brain catch-up growth in preterm infants or infants with low-birth weight.
Nestec S.a.

Inhibitors of ncca-atp channels for therapy

Methods and compositions are provided that are utilized for treatment and/or prevention of intraventricular hemorrhage or progressive hemorrhagic necrosis (phn), particularly following spinal cord injury. In particular, the methods and compositions are inhibitors of a particular ncca-atp channel and include, for example, inhibitors of sur1 and/or inhibitors of trpm4.
The United States Of America As Represented By The Department Of Veterans Affairs

Compositions for improvement of brain function

A composition comprising alpha-ketoglutaric acid or a pharmaceutically acceptable salt thereof (akg), and one or more enzymes selected from a group consisting of a lipase, a protease and an amylase, and medical uses thereof in, neurological and/or neurodegenerative disease, neurological trauma, depression or chronic fatigue syndrome.. .
Grespo Ab

Methods of intravenous administration of glyburide

The present disclosure is drawn to a method of treating a patient in need of treatment, comprising identifying a patient in need of treatment for stroke, traumatic brain injury, spinal cord injury, myocardial infarction, shock, organ ischemia, ventricular arrhythmias, ischemic injury, or hypoxia/ischemia; administering a bolus of glyburide to the patient; and administering a continuous infusion of glyburide to the patient at from about 15 μg/hr and about 300 μg/hr, wherein the continuous infusion glyburide is administered for a period of time more than about 20 hours.. .
Biogen Chesapeake Llc

Surgical apparatus, in particular a navigation probe for localizing and treating lesions in a brain

A means for maneuvering said body member (10).. .

Methods and systems for identifying non-penetrating brain injuries

The present disclosure provides methods for identifying non-penetrating brain injury in a subject, as well as methods for classifying a subject that received a hit to the body that transmitted an impulsive force to the brain as either having a non-penetrating brain injury or not, by analyzing one or more components of frequency-following response (ffr) following administration of an acoustic stimulus to the subject. In addition, the present disclosure provides methods for assessing a subject's recovery from a non-penetrating brain injury.
Northwestern University

Neurocerebral assessment using stimulated eeg response

The present disclosure provides methods, systems and devices for assessing brain neural activity and/or characteristics by providing at least two tms stimulation pulses, obtaining an eeg indicative of brain activity responses associated with the at least two tms stimulation pulses and compare the brain activity responses to evaluate neural characteristic of the brain.. .
Nibs Neuroscience Technologies Ltd.

Deep brain source imaging with m/eeg and anatomical mri

A method for non-invasively resolving electrophysiological activity in sub-cortical structures located deep in the brain by comparing amplitude-insensitive m/eeg field patterns arising from activity in subcortical and cortical sources under physiologically relevant sparse constraints is disclosed. The method includes a sparse inverse solution for m/eeg subcortical source modeling.
Massachusetts Institute Of Technology

Methods and devices for color detection to localize the blood mass of an intracerebral hematoma

Devices for localizing an intracerebral hematoma or blood mass in brain tissue. The devices include an elongate probe a color sensors and a light emitter on the distal end of the probe.
Rebound Therapeutics Corporation

Cannula with proximally mounted camera

A cannula with a proximally mounted camera provides visualization of the brain during minimally invasive surgery. The device comprises a cannula with a camera mounted on the proximal end of the cannula with a view into the cannula lumen and the surgical field below the lumen.
Rebound Therapeutics Corporation

Universal protective headgear

A universal protective headgear device wraps around a user's head to cover and protect crucial areas around the entire circumference of the cranium while conforming to each user's particular anatomy, including head shape and size. Pads formed of impact absorbing polymers having full elastic memory are fitted within the headgear, between inner and outer layers of moisture absorbing material, such as neoprene or knitted fabric.

Method and system for direct communication

Information is communicated to an individual by directing an acoustic signal transcranially to a target region in the brain. The target region is stimulated to produce a cognitive effect, and the cognitive effect is modulated or encoded to carry the desired information..
Cerevast Medical, Inc.

Method for simultaneous time-interleaved multislice magnetic resonance imaging

Methods for reducing scan time in magnetic resonance imaging (“mri”), particularly when imaging three-dimensional image volumes, using a simultaneous time-interleaved multislice (“stims”) acquisition are described. The unused time in each repetition time (“tr”) period is exploited to provide an additional reduction in encoding time for a three-dimensional acquisition (e.g., a 3d whole brain coverage).
The General Hospital Corporation

Blockade of tim-1 pathways and p-selectin pathways in treatment of neuroinflammatory degenerative disease

Methods for treating, preventing and reducing the progression of neurodegenerative and neurological diseases, including, without limitation alzheimer's disease, are provided. The methods of the invention inhibit one or both of tim-1 and p-selectin function and reduce leukocyte and platelet cell adhesion, activation and interaction with the vascular endothelium and infiltration of leukocytes into the brain..
Leuvas Therapeutics

Rapid diagnostic kit for central nervous system afflictions and traumatic brain injuries

A method and system for diagnosing concussions, tbi, cte and other central nervous system disorders is provided. A diagnostic kit includes a tube containing a predefined amount of lyophilized biomarker-specific antibody conjugated to a conjugate with a color functionality, a fluid for mixing with the lyophilized biomarker-specific antibody conjugated to the conjugate within the tube, so as to reconstitute the lyophilized biomarker-specific antibody conjugated to the conjugate, resulting in a reconstituted mixture, and a swab comprising an absorbent hydrophobic material, the swab configured for absorbing cerebrospinal fluid when swabbed on a patient, wherein when the swab that has absorbed cerebrospinal fluid is placed in the tube containing the reconstituted mixture, the swab is configured to change color..
Applied Nuerologics, Llc

Method and system for combining anatomical connectivity patterns and navigated brain stimulation

When operating a brain stimulation device, it is critical to understand and control the network effects associated with the area being targeted for stimulation. The combined system and methods provided herein provides the operator with a real-time view of the brain network potentially affected by the stimulation.
Nexstim Oyj

Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin

The present invention relates to antibody-polypeptide-cytotoxin conjugates and methods of making, packaging, and using the conjugates. The polypeptide can be a kunitz-type protease inhibitor or a derivative thereof that facilitates transport of the conjugate across the blood-brain barrier and/or into cancer cells outside the cns, and the antibody moiety selectively binds a target within the cns or in peripheral tumors to direct the cytotoxic agent to that target (e.g., a tumor or cancer cell).
Angiochem Inc.

Novel immunotherapy against several tumors including neuronal and brain tumors

A method of treating a patient who has brain cancer includes administering to said patient a composition containing a population of activated t cells that selectively recognize cells in the patient that aberrantly express a peptide. A pharmaceutical composition contains activated t cells that selectively recognize cells in a patient that aberrantly express a peptide, and a pharmaceutically acceptable carrier, in which the t cells bind to the peptide in a complex with an mhc class i molecule, and the composition is for treating the patient who has brain cancer.
Immatics Biotechnologies Gmbh

Brain and neural treatments comprising peptides and other compositions

The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth, muscle repair, improved muscular and neuromuscular control, and treatments for neuromuscular and neurological disorders, including brain disorders. In some cases, the composition may include nitric oxide and/or peptides.
Transdermal Biotechnology, Inc.

Central nervous system treatment device and methodology

The invention relates to a method of central nervous system pathology treatment through selective hypothermia. brain and spinal cord cooling is achieved through a closed loop catheter system inserted directly into the cerebrospinal fluid space.

Authentication device using brainwaves, authentication method, authentication system, and program

Provided are a highly confidential personal authentication device which uses brain waves, a personal authentication method, and a personal authentication system and program. The authentication device using brain waves is provided with: an electroencephalograph; and a processing unit which, with respect to brain waves with respect to a plurality of stimulus events obtained by the electroencephalograph, determines a discrimination score according to a discrimination model for estimating brain information for each authentication candidate accumulated in advance, based on a discrimination-model-to-discrimination-model comparison of the discrimination score, identifies and authenticates an authentication candidate who provided the model.
National Institute Of Advanced Industrial Science And Technology

System for motor rehabilitation of a paretic limb in stroke patients

Wherein upon carrying out a series of training sessions, each session comprising at least a set of such instructions, the hybrid brain machine interface is configured to switch between controlling the movements of the body-actuator based on the decoded brain neurosignals and a hybrid control of the movements of the body-actuator, when a significant level of decodable emg activity has been registered, the hybrid control being an emg-gated brain control.. .

Apparatus and electroencephalographic measurement

An apparatus comprises a data processing unit and a stimulator. The data processing unit receives first electroencephalographic data based on a measurement of a brain of a person exposed to one or more estimated or measured non-zero amounts of anesthetic drug substance.
Oulun Yliopisto

Modifying the modality of a computing device based upon a user's brain activity

Technologies are described herein for modifying the modality of a computing device based upon a user's brain activity. A machine learning classifier is trained using data that identifies a modality for operating a computing device and data identifying brain activity of a user of the computing device.

Modifying a user interface based upon a user's brain activity and gaze

Technologies are described herein for modifying a user interface (“ui”) provided by a computing device based upon a user's brain activity and gaze. A machine learning classifier is trained using data that identifies the state of a ui provided by a computing device, data identifying brain activity of a user of the computing device, and data identifying the location of the user's gaze.

Magnetic resonance imaging of neuro-electro-magnetic oscillations

In vivo methods of non-invasively imaging neuro-electro-magnetic oscillations (nemo) are carried out by electronically transmitting a pulse sequence to a subject. The pulse sequence has a first excitation pulse, typically applied along an x-axis, followed by a spin-lock pulse applied along a different axis, typically a y-axis, and having a defined frequency, followed by a second rf excitation pulse.
Duke University

Method and system for providing electrical stimulation to a user

A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit.. .
Halo Neuro, Inc.

Therapeutic multi-peptides t specific immune therapy for treatment of brain metastasis

The present invention relates to a peptide vaccine composition ose-2101 for treatment of brain metastasis in hla-a2 positive patients.. .
Ose Immunotherapeutics

Compounds for use in the prevention or treatment of cancer

The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field.
Fujimoto Co. Ltd.

System that measures different states of a subject

An analysis system analyzes a state of a person and includes a terminal configured to be worn on the person's body. The terminal includes an acceleration sensor, a storage unit, and a processing unit.
Hitachi, Ltd.

Device and measuring blood oxygen level and/or detecting brain hematoma

A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third nir wavelengths across the brain of the subject.
Mackay Memorial Hospital

Method for locating tracts of electrical brain activity

A method and apparatus for locating tracts of electrical brain activity. A source localization procedure may be performed including solving the inverse problem subject to one or more constraints resulting from a tractographic procedure, and a tractographic procedure may be performed that includes obtaining a probabilistic assessment of tract connectivity that takes account of the results of a source localization procedure..
Electrical Geodesics, Inc.

Customization of help information based on eeg data

A method (100) is implemented by a computing device for helping a particular user use a user interface (ui). Electroencephalography (eeg) data is obtained (102) that indicates brain activity of a particular user during a period in which that user views the ui and/or interprets help information that describes how to use the ui.

Digital command prompting device

The digital command prompting device is an aid is to help all people, especially those who have special needs particularly individuals who have diminished or diminishing function of their brain. The device is predominately mobile but can also be stationary and can be programmed by receiving and selecting pre-set commands to operate and assist a user with their daily living standards or needs.

Method of diagnosing and treating brain endothelial inflammation related disease

The presently claimed invention relates to materials and methods for diagnosing a chronic inflammatory disease in a patient comprising testing a biological sample from the patient for a level of a first neurovascular biomarker of lymphatic activation and diagnosing the patient as having the chronic inflammatory disease if the tested level of the first neurovascular biomarker of lymphatic activation is less than a first normal level.. .

Devices and methods of low frequency magnetic stimulation therapy

Described herein, in certain embodiments, are devices and methods for modulating the electrical activity of a brain in a targeted manner using a weak magnetic field, generally field with a strength of less than about 100 gauss. The magnetic field is varied over time in a periodic manner, generally with a frequency tuned to specifically affect one of the intrinsic frequencies of the brain, optionally the alpha frequency.

Transcranial control of procedural memory reconsolidation for skill acquisition

Described is a system for the therapeutic modification of human behavior and, more specifically, a system for the transcranial control of procedural memory reconsolidation for the purposes of enhanced skill acquisition. During operation the system records a practice pattern.

System and training and assessment

Described is a system for training and assessment. In operation, the system classifies a subject's baseline brain state and behavioral performance.

Sleep inducing device and sleep management system including same

A sleep inducing device and a sleep management system including the same are provided. The sleep inducing device comprises: a housing unit that includes a frame of which the shape can be changed; a sensor unit that is disposed on one surface of the housing unit and includes a brain-wave measurement sensor that measures a user's brain wave; an output unit that includes a first output unit and a second output unit, wherein the first output unit is located on one side of the housing unit to output a sound or light with a first frequency, and the second output unit is located on an opposite side of the housing unit to output a sound or light with a second frequency that is different from the first frequency; and a control unit that calculates the user's sleep pattern on the basis of the brain wave signal measured by the sensor unit and changes the output signal of the output unit such that the sleep pattern approaches a predetermined value..

Method for treating a brain tumour

A method of treating a brain tumour such as glioblastoma in a mammal is provided comprising administering to the mammal a drd4 antagonist.. .

Method for improving interstitial flow

Provided is a prophylactic and/or therapeutic drug for mild cognitive impairment, which can improve interstitial flow in cerebral blood vessel and the like to achieve sufficient clearance of harmful proteins accumulated in the brain. The prophylactic and/or therapeutic drug includes 6-[4-(1-cyclohexyl-1h-tetrazole-5-yl)butoxy]3,4-dihydrocarbostyril or a salt thereof as an active ingredient.

Methods of preventing and treating cerebral amyloid angiopathy (caa) with an edaravone medicament

The present invention belongs to pharmaceutical field, specifically, relates to use of edaravone in the preparation of a medicament for preventing and treating cerebral amyloid angiopathy (caa). By administering edaravone, the present invention could scavenge the deposited amyloid (aβ) in the brain and prevent the intracerebral aβ deposition..

Electromagnetic guiding tube for elongated medical implants

The present invention relates to a guiding tube for placing medical implants within body tissue, comprising an elongated, dimensionally stable tubular body encompassing an inner channel adapted to receive a medical implant, wherein the tubular body comprises at least one electromagnetic element, which is configured to exert an electromagnetic force on at least one magnetic element of the medical implant inserted into the inner channel. The present invention further relates to a corresponding medical implant for being placed within body tissue, particularly a stimulation lead, specifically a deep brain stimulation lead comprising at least one directional electrode, having an elongated body portion that is adapted to be inserted into an inner channel enclosed by a tubular body of a guiding tube, wherein at least one magnetic element provided on or in the body portion.

Methods for detecting and treating pain using brain activity

Disclosed are methods for detecting pain in a subject, such as a mammal (e.g., a human), using brain activity, e.g., as determined by electroencephalography. The methods are useful for treating or reducing the likelihood of pain in a subject by determining power amplitude from the power spectral density of the waveforms and, e.g., administering a therapeutic agent to the subject.

Sleep stage detection

Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient.

Method and processing electroencephalogram (eeg) signals

A method of processing eec signals received from a plurality electrodes. The method comprises processing the eec signals to determine a modulation index value for each electrode, determining one or more electrodes that have a modulation index value above a threshold level observed during ictal activity, and using the determined one or more electrodes, to identify one or more possible regions of interest corresponding to seizure zones of a subject's brain..

Electroencephalograph, brain wave measurement method, brain wave measurement system

The object is to acquire electroencephalogram of high resolution with fewer number of electrodes than usual. An electroencephalogram measurement apparatus comprising: a plurality of electrodes 110 attached on the scalp of a subject for acquisition of electroencephalogram signals of the subject; and an electroencephalogram generation unit 150 for generating an electroencephalograms at locations of the scalp where the electrodes are attached and electroencephalograms at locations of the scalp where the electrodes are not attached..

Non-contact body and head based monitoring of brain electrical activity

Apparatus and methods for monitoring electrical activity within the brain of a person (“brainwaves”) employing electrodes or other sensors placed proximate to portions of the body below the head to develop raw signals without physically touching the body and penetrating hair and clothing. Additionally, apparatus and methods for monitoring electrical activity within the brain of a person (“brainwaves”) employing non-contacting sensors placed proximate to portions of the head to develop raw signals.

Methods, computer-readable media, and systems for measuring brain activity

One aspect of the invention provides a method including: obtaining neural activity data for a first subject and a second subject during verbal interaction between the first subject and the second subject; and calculating coherence between the neural activity data for the first subject and the neural activity data for the second subject. Another aspect of the invention provides a non-transitory, tangible computer-readable medium comprising computer-readable program instructions for implementing the one or more of the methods described herein..

Systems, methods, and devices for detection and diagnosis of brain trauma, mental impairment, or physical disability

Systems, devices, and methods are disclosed which may be used to detect and determine the extent of brain trauma, mental impairment, physical disability, or other brain dysfunction by tracking one or more ocular responses.. .

Mems valve actuator system and method

A micro-electro-mechanical (mems) exhaust valve-based impact attenuating fluid filled cell for use in cushioning impact and decelerating of a wearer's body portion (e.g. Head, shoulder, torso, etc.) after an impact.

Systems and methods for enhancing a signal-to-noise ratio

Provided are methods and apparatus for enhancing a signal-to-noise ratio. In an example, provided is an apparatus configured to modify audio to better match the way the human brain processes audio by modifying the audio to a form which takes advantage of human echolocation capabilities.
Signal/noise Solutions L.l.c.

Planning, navigation and simulation systems and methods for minimally invasive therapy

Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery..
Synaptive Medical (barbados) Inc.

Evaluation apparatus and evaluation method

An evaluation apparatus comprises a brain wave acquiring unit that acquires a brain wave signal from each of a plurality of subjects; an intensity data generating unit that generates intensity data that represents an intensity of a signal component in a predetermined frequency band or a relation between intensities of signal components in a plurality of frequency bands; a correlation data generating unit that acquires pairs of two subjects for all combinations, calculates a cross-correlation coefficient for the intensity data at each point in time for the respective pairs, and generates, correlation data in the time-series form; and an output unit that generates evaluation data that numerically represents a degree of synchronization of brain wave fluctuation based on the correlation data.. .
Centan Inc.

Diagnostic method

A method of detecting the presence, or monitoring the severity of a condition characterised by the presence of fragments of a marker protein in the brain of a patient. The method comprises: (i) providing a sample comprising macrophages obtained from the patient; and (ii) detecting the presence of the marker protein or fragments thereof in the macrophages.
Inven2 As

Methods for treating neural cell swelling

A composition comprising a novel ca2+-activated, [atp]i-sensitive nonspecific cation (ncca-atp) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [ca]i.
The United States Of America As Represented By The Department Of Veterans Affairs

High throughput sequencing

The invention relates to a high throughput method for determining telomere length of mammalian chromosomal dna; primers for use in said method; a kit comprising said primers; use of said method to diagnose or prognose or to determine the risk of developing a telomere shortening disease such as cancer, ageing, neurological disorders including alzheimer's disease, parkinson's disease and other dementias, brain infarction, heart disease, chronic hiv infection, chronic hepatitis, skin diseases, chronic inflammatory bowel disease including ulcerative colitis, anaemia, atherosclerosis, barrett's oesophagus and cancers including pre-cancerous conditions, infertility, telomere syndromes including dyskeratosis congenita, aplastic anaemia, idiopathic pulmonary fibrosis, familial myelodysplastic syndrome-acute myeloid leukaemia, hoyeraal-hreiderasson syndrome, revesz syndrome, coats plus syndrome, bone marrow failure, and cryptogenic liver cirrhosis. Additionally, the invention also has application in assessing an individual's suitability to be a transplantation donor, for example a bone marrow donor..

B-lamella blocking peptide used for preventing and/or treating alzheimer's disease

Provided in the present invention are a β-sheet breaker peptide used for preventing and/or treating alzheimer's disease, and the use thereof for preventing and/or treating alzheimer's disease. The amino acid sequence of the β-sheet breaker peptide is his-lys-gln-leu-pro-phe-tyr-glu-glu-asp (seq id no:1).
Tianjin Medical University

Pro-neurogenic compounds

Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, parkinson's disease, alzheimer's disease, down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like..
Board Of Regents Of The University Of Texas System

Composition and treating metabolic disorders

Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of metabolic disorders, including prediabetes, obesity, insulin resistance, hyperinsulinemia, hyperglycemia and type 2 diabetes mellitus (t2dm) and/or, e.g., the treatment of other medical disorder(s) including immune or endocrine disorders or diseases. Bromocriptine citrate is administered over a limited or extended period at a time of day dependent on re-establishing the normal circadian rhythm of central dopaminergic activity of healthy members of a similar species and sex.
Veroscience Llc

Heteroaryl compounds comprising nitrogen and use thereof

The compounds according to the present invention exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer with a reduced dose compared to that of existing drugs. Accordingly, the compounds can be effectively used for treating various types of cancer, such as uterine cancer, breast cancer, gastric cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, pancreatic cancer, renal cancer, prostate cancer, bladder cancer, and liver cancer, and for inhibiting proliferation of cancer cells and metastasis of cancer..

Brain stimulation response profiling

Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses.
Medtronic, Inc.

Adaptive cognitive prosthetic and applications thereof

An adaptive cognitive prosthetic that learns to replace neural function that was lost due to a brain injury or disease is described herein. In some embodiments, an adaptive cognitive prosthetic comprises a processing unit for converting input data from an input assembly into a cognitive variable and selecting a stimulation pattern for conveying the cognitive variable.
The Trustees Of Princeton University

Systems and methods for network based neurostimulation of cognitive processes

This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.. .
The Board Of Regents Of The University Of Texas System

Adjunctive therapy delivery using a dbs lead

Various aspects of the present disclosure are directed toward apparatuses, systems and methods for treating an ischemic brain injury. Certain aspects include delivering the treatment substrate to a therapy region in a patient's brain.
Boston Scientific Neuromodulation Corporation

Systems and methods for preventing, mitigating, and/or treating dementia

The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-β (aβ) peptide, c-terminal fragment-β (β-ctf), β-secretase (bace1), γ-secretase, neuroinflammation, and/or dementia (e.g., alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (fs-pv) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.. .

Systems for brain stimulation during sleep and methods of use thereof

The present invention relates to systems for brain stimulation during sleep and methods for increasing vividness of a subject's dreams or for directing the subject matter of a subject's dreams. The system comprises a brain stimulation module and at least one of a brain energy source and/or a hypnotic source.
Able Cerebral, Llc

Angiopep and derivatives thereof for imaging amyloids

The present application relates to the molecular labeling and in vivo imaging of amyloids. Specifically, the present application relates to a polypeptide-based method/vector for targeting amyloids.
University Of Science And Technology Of China

Regenerating functional neurons for treatment of disease and injury in the nervous system

Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing neurod1 into a glial cell, particularly into a reactive astrocyte or ng2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous neurod1 in the glial cell, wherein expressing exogenous neurod1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous neurod1 to the glial cell..
The Penn State Research Foundation

Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications

The present invention provides oligopeptides, in particular, ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury..
Arizona Board Of Regents On Behalf Of The University Of Arizona

Sglt-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease

The present invention relates to certain sglt-2 inhibitors, such as ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof, for treating and/or preventing metabolic disorders, such as type 1 or type 2 diabetes mellitus or pre-diabetes, in patients with renal impairment or chronic kidney disease (ckd). The present invention also relates to methods for preventing neuronal damage following the incidence of ischemic stroke and close-head traumatic brain injury in animals comprising the step of administering to an animal, in need of such treatment, a therapeutically effective amount of ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof..
Pfizer Inc.

Uses of chlorogenic acid in the preparation of medicaments for treatment of mesoglioma

The present invention provides uses of chlorogenic acid in the preparation of medicaments for treatment of mesoglioma. Chlorogenic acid according to the present invention has an inhibitory action against mesoglioma, and can inhibit the growth of brain tumor stem cells, thus can partly substitute chemoradiation.
Sichuan Jiuzhang Biological Science And Technology Co., Ltd

Baclofen formulations and methods for making same

Methods for preparing sterilized baclofen solutions include adjusting the ph to below a desired ph, and steam sterilizing the solution with adjusted ph, which results in the solution having the desired ph. Such solutions may also have low concentrations of 4-cpp.
Saol International Limited

Reducing brain injury by limiting brain motion during sudden deceleration or acceleration of the head

A brain injury reduction system provides a protective measure that temporarily or decreases venous drainage out of the intracranial compartment during or immediately before and during a sudden change in acceleration of an individual's head. Specifically, a wearable helmet or other wearable structure of the brain injury reduction system detects an impending collision and determines whether a protective measure is needed.
Slomo Technologies, Llc

Methods and systems for controlling body parts and devices using ipsilateral motor cortex and motor related cortex

A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain.
Washington University





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