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Brain patents

      

This page is updated frequently with new Brain-related patent applications.

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 Method and  interacting information between smart terminal and wearable device patent thumbnailMethod and interacting information between smart terminal and wearable device
A method and an apparatus for interacting information between a smart terminal and a wearable device are provided. The method includes: acquiring first control information containing behavior information of a tester; acquiring second control information containing brain wave information of the tester; comparing the first control information with the second control information to obtain a comparison result; and executing the first control information when the comparison result indicates that the first control information is consistent with the second control information.
Zte Corporation


 Method and  examining brain injury due to impact patent thumbnailMethod and examining brain injury due to impact
An impact test system includes a head model having a head exterior component; a skull component; a brain component; a fluid component; an interior cavity surface; and a translucent cover, wherein the head model is coupled with a mount, the brain component and fluid components are configured within the interior cavity, and wherein the translucent cover is configured over a portion of the brain component and fluid component. A mount is configured to a least partially restrain the head model.
Villanova University


 Low affinity blood brain barrier receptor antibodies and uses thereof patent thumbnailLow affinity blood brain barrier receptor antibodies and uses thereof
The present invention relates to antibodies that bind blood brain barrier receptors (bbb-r) and methods of using the same.. .
Genentech, Inc.


 Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease patent thumbnailProtein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of alzheimer's disease and related tauopathies.
Axon Neuroscience Se


 Gamma-diketones as wnt/beta -catenin signaling pathway activators patent thumbnailGamma-diketones as wnt/beta -catenin signaling pathway activators
The present disclosure provides γ-diketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .
Samumed, Llc


 Brainwave virtual reality apparatus and method patent thumbnailBrainwave virtual reality apparatus and method
New human bio-sensors in a virtual reality headset can be worn comfortably for extended periods of time, detecting brain, nerve, ocular, muscle or other bio-signals. Recording raw data, amplification, digital conversion, filtering, support subsequent manipulation by iteratively creating multiple interpretation maps.

 Method for transiently disrupting a region of the blood-brain barrier of a human patent thumbnailMethod for transiently disrupting a region of the blood-brain barrier of a human
The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (bbb) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (us) beam with a pressure level higher than 1 mpa and a resonance frequency ranging from 0.5 to 1.5 mhz..
Universite Pierre Et Marie Curie (paris 6)


 Systems and methods for pain treatment using spinal nerve magnetic stimulation patent thumbnailSystems and methods for pain treatment using spinal nerve magnetic stimulation
Described are methods, devices, and systems for a novel, easy-to-use treatment for pain that does not involve medication. Methods and devices herein use repetitive magnetic fields that desensitize the spinal nerve, thereby affecting transmission of pain signals from the treatment location to the brain..
Kosivana Holdings Limited


 Wireless midfield systems and methods patent thumbnailWireless midfield systems and methods
Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University


 Device and  effective invasive neurostimulation by means of varying stimulus sequences patent thumbnailDevice and effective invasive neurostimulation by means of varying stimulus sequences
A device is provided for stimulating neurons that includes an implantable stimulation unit that generates stimuli in multiple stimulation elements. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation elements.
Forschungszentrum Juelich Gmbh


Systems and methods for disrupting neuronal oscillation using deep brain stimulation

The present disclosure provides systems and methods for disrupting neuronal oscillations. A neurostimulation system includes a stimulation lead comprising at least one contact, and an implantable pulse generator (ipg) communicatively coupled to the stimulation lead and configured to cause stimulation to be applied to a patient using no more than two contacts of the stimulation lead by causing a first burst of stimulation to be delivered, and causing a second burst of stimulation to be delivered within a neuronal refractory period that follows the first burst of stimulation..
Pacesetter, Inc.

Medical therapy target definition

In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes.
Medtronic, Inc.

Injectable neurosteroid formulations containing nanoparticles

Where the variables r1-r9 and x are defined herein and at least one surface stabilizer. The surface stabilizer can be a polymeric surface stabilizer such as hydroxyethyl starch, dextran, or povidone.

Angiotensin in treating brain conditions

The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include administering to a subject suffering from or susceptible to a brain condition an angiotensin (1-7) peptide via either an intravenous or subcutaneous route of administration..
Tarix Pharmaceuticals Ltd.

Methods for treating brain metastasis

The present invention relates to methods for treating brain metastasis by inhibiting gap junction functionality. It is based, at least in part, on the discovery that cancer cells expressing protocadherin 7 and connexin 43 form gap junctions with astrocytes that promote the growth of brain metastases, and that inhibition of protocadherin 7 and/or connexin 43 expression in cancer cells reduce progression of brain metastases.
Memorial Sloan-kettering Cancer Center

Self-micellizing fatty acids and fatty acid ester compositions and their use in the treatment of disease states

Described herein are compositions including at least one omega-3 fatty acid (either in the triglyceride, ester or free fatty acid ester form) and at least one surface active agent; wherein the compositions form micelles when in contact with an aqueous medium. Also provided are methods of administering to a subject a composition including at least one omega-3 fatty acid (either in the triglyceride, ester or free fatty acid ester form) and at least one surface active agent, wherein the compositions form micelles when in contact with an aqueous medium, and the bioavailability of the omega-3 fatty acid is substantially independent of a food effect.
Sancilio & Company, Inc.

Glutamine enriched nutritional composition for preterm infants

The present invention relates to the use of nutritional compositions enriched in glutamine to improve structural and functional brain development in preterm and/or low birth weight infants.. .
N.v. Nutricia

Nanovectors for penetrating brain tumor tissues to conduct gene therapy

A method of selectively targeting a cell with a therapeutic agent, the method comprising: targeting a cell with a nanospear, puncturing the cell with said nanospear; releasing a therapeutic agent from said nanospear, wherein said therapeutic agent enters said cell, thereby effecting the efficacy of said cell.. .
University Of Houston System

Elevation timing head up cpr

A method for performing cardiopulmonary resuscitation (cpr) includes elevating the head, heart and shoulders of an individual from a starting elevation angle to a final elevation angle greater than zero degrees relative to horizontal while performing cpr by repeatedly compressing the chest. The method includes elevating the brain within a time period selected to be slow enough to permit a sufficient amount of blood to flow to the brain throughout the elevation time period.

Optimal dosages for low energy shock wave treatment of vital organs

The treatment of various sensitive organs with low energy acoustic shockwaves has been proposed. However, the prior art is lacking in guidance as to what constitutes an efficacious minimum dosage or a safe maximum dosage for various target organs and tissues.
The Regents Of The University Of California

Virpet - combination of virtual reality and pet brain imaging

Various methods, systems and apparatus are provided for brain imaging during virtual reality stimulation. In one example, among others, a system for virtual ambulatory environment brain imaging includes a mobile brain imager configured to obtain positron emission tomography (pet) scans of a subject in motion, and a virtual reality (vr) system configured to provide one or more stimuli to the subject during the pet scans.
West Virginia University

Method and prediction of epileptic seizures

A system for predicting epileptic seizures includes sensors operable to record a wearer's brain activity. The sensors electronically communicate with a processor configured to receive and store output eeg oscillations and activities.
University Of Windsor

Coated biosensor and preserving biosensor during implantation into the brain or other tissues

Provided herein is a coated biosensor and a method of preserving a coated biosensor to protect it during implantation into the brain or other tissues by coating the biosensor with a protective coating.. .
Diagnostic Biochips, Inc.

Early detection of neurodegenerative disease

Embodiments of the present systems and methods may provide a non-invasive system to measure and integrate behavioral and cognitive features enabling early detection and progression tracking of degenerative disease. For example, a method of detecting neurodegenerative disease may comprise measuring functioning of at least one of the motor system, cognitive function, and brain activity of a subject during everyday life and analyzing the gathered at least one motor system data, cognitive function data, and brain activity data of the subject..

Neuroanalytic, neurodiagnostic, and therapeutic tools

Embodiments may provide multimodal diagnostic systems and methods for detecting neurological disorders, such as alzheimer's disease (ad), parkinson's disease (pd), depression, ptsd, schizophrenia, dementia and many others. For example, a system for monitoring brain activity may comprise a plurality of sensors, each adapted to monitor a physical or physiological parameter and output a signal representing the monitored physical or physiological parameter, wherein the plurality of sensors includes at least one sensor configured to monitor a brain activity parameter, a data collection device adapted to receive the plurality of signals from the plurality of sensors and to process the signals to form digital data representing the monitored physical or physiological parameters, and a data processing device adapted to process digital data representing the monitored physical or physiological parameters to determine presence of a neurological disorder or condition..

Leveraging on local and global textures of brain tissues for robust automatic brain tumor detection

A method for performing cellular classification includes generating a plurality of local dense scale invariant feature transform (sift) features based on a set of input images and converting the plurality of local dense sift features into a multi-dimensional code using a feature coding process. A first classification component is used to generate first output confidence values based on the multi-dimensional code and a plurality of global local binary pattern histogram (lbp-h) features are generated based on the set of input images.
Siemens Healthcare Gmbh

Apparatus for improving vision acuity in points of interest of the visual field

Eyewear for enhancing the contrast sensitivity of the human vision system through the use of lenses subdivided in areas of different light filtration properties arranged in specialized patterns, called multi-filters patterns, are provided. Of the multiple filtration areas, or filters, that compose each multi-filters patterns, one or more filters heavily reduces or totally block light arriving from some areas of the visual field of the eyes , while other filters lightly reduce or totally allow light from other areas of the same visual field.

Methods and kits for detecting and diagnosing neurotrauma

Methods and kits for detecting and diagnosing neurotrauma (e.g., traumatic brain injury, stroke, or spinal cord injury) are provided. These methods rely on the determination of lysophosphatidic acid (lpa) and/or lpa metabolite levels in patient samples following suspected injury..

Method for producing cerebellar progenitor tissue

The present invention provides a method for producing a human cell aggregate containing a midbrain-hindbrain boundary neural progenitor tissue, including subjecting an aggregate of human pluripotent stem cells to suspension culturing in a serum-free medium containing insulin, and treating, in the suspension culturing, the aggregate of human pluripotent stem cells or a human cell aggregate derived therefrom with a rock inhibitor, a tgfβ signal inhibitor, and a first fibroblast growth factor. Furthermore, the human cell aggregate containing the midbrain-hindbrain boundary neural progenitor tissue is subjected to suspension culturing in a serum-free medium to induce formation of a neuroepithelial structure by neural progenitor in the neural progenitor tissue, whereby the human cell aggregate containing the cerebellar plate tissue can be obtained..
Sumitomo Chemical Company, Limited

Modulation of leukocyte activity in treatment of neuroinflammatory degenerative disease

Methods for treating and reducing the progression of neurodegenerative diseases, including, without limitation alzheimer's disease, are provided. The methods of the invention reduce or deplete neutrophil/myeloid cells in the region of the brain by blocking neutrophil/myeloid cell adhesion and interaction with the vascular endothelium, by blocking infiltration of neutrophil/myeloid cells into the brain, by reducing motility of neutrophil/myeloid cells in the parenchyma, by blocking aβ-induced activation and adhesion of neutrophil/myeloid cells, and/or by blocking aβ-induced integrin activation, degranulation and/or ros release in neutrophil/myeloid cells..
Leuvas Therapeutics

Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors

The present invention provides a novel chromone oxime derivative of formula (i), which is a modulator of nervous system receptors sensitive to glutamate and, furthermore, presents an advantageously high brain penetration upon oral administration. The invention also relates to a pharmaceutical composition containing this compound, and to its use for the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions, or conditions which can be affected by alteration of glutamate level or signalling, particularly acute and chronic neurological and/or psychiatric disorders..
Prexton Therapeutics Sa

Audio tone programmed hygienic and therapeutic sleep and wake eye mask having remotely controlled sunrise and sunset multimodes

An eye mask for use to wake up and/or to go to sleep provides ease of cleaning or replacement without damaging electrical or optical components; different user selectable sunrise and sunset illumination modes respectively having blue-shifted and red-shifted spectra simulating natural sunrises and sunsets to assimilate the sleep/wake cycle to the natural rhythms of day and night; sunset and/or sunrise illumination modes that oscillate with fixed period or sequentially changing periods that correspond to brainwave frequencies that respectively facilitate going to sleep and/or waking and synergistically co-operate with corresponding sunset or sunrise light fields to help the user to fall into restful sleep or to awake refreshed and alert; and audio tone programming of illumination mode and treatment time and/or duration of therapy by a remote tone control generator.. .
Headwaters Research & Development Inc

Apparatus and methods for improving health outcomes of preterm infants

Adverse effects of pain in a premature infant, especially a very or extremely premature infant may be ameliorated by exposing the infant to stimuli comprising one or more of vertical oscillating motion simulating breathing, skin contact with an interface that mimics human skin and exposure to sounds and/or vibrations that simulate heartbeats. A device including a movable platform provides such stimuli within a neonatal intensive care incubator.
British Columbia Cancer Agency Branch

Systems and methods for attracting and trapping brain cancer cells

Described herein are systems and methods for attracting and trapping cancer cells at a specific site where focal radiation and/or surgical resection and/or chemotherapeutics can eliminate them.. .
Geisinger Health System

Brain and neural treatments comprising peptides and other compositions

The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth, muscle repair, improved muscular and neuromuscular control, and treatments for neuromuscular and neurological disorders, including brain disorders. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (trh) and/or gnrh (gonadotropin-releasing hormone).
Transdermal Biotechnology, Inc.

Method for treating parkinson disease, neurodegenerative disorders, and autoimmune diseases

The embodiments herein relate to a therapeutic method for the treatment of parkinson disease, other neurodegerative disorders, and autoimmune diseases. The method includes providing sodium thiosulfate through any method of administration (orally, intravenously, through inhalation, intravesically, vaginally, rectal route, sublingually, ophthalmically, or topically) and is given with one or more pharmaceutically acceptable carriers or excipients.

Dnp and dnp prodrug treatment of neuromuscular, neurodegenerative, autoimmune, developmental, traumatic brain injury, concussion, dry eye disease, hearing loss and/or metabolic diseases

A composition and method of treatment of neuromuscular, neuromuscular degenerative, neurodegenerative, autoimmune, developmental, traumatic, hearing loss related, and/or metabolic diseases, including spinal muscular atrophy (sma) syndrome (sma1, sma2, sma3, and sma4, also called type i, ii, iii and iv), traumatic brain injury (tbi), concussion, keratoconjunctivitis sicca (dry eye disease), glaucoma, sjogren's syndrome, rheumatoid arthritis, post-lasik surgery, anti-depressants use, wolfram syndrome, and wolcott-rallison syndrome. The composition is selected from the group consisting of 2,3-dnp, 2,4-dnp, 2,5-dnp, 2,6-dnp, 3,4-dnp, or 3,5-dnp, bipartite 2,3-dinitrophenol, 2,4-dinitrophenol, 2,5-dinitrophenol, 2,6-dinitrophenol, 3,4-dinitrophenol, or 3,5-dinitrophenol (2,3-dnp, 2,4-dnp, 2,5-dnp, 2,6-dnp, 3,4-dnp, or 3,5-dnp) prodrugs; gemini prodrugs, bioprecursor molecules, and combinations thereof.
The Board Of Trustees Of The University Of Arkansas Acting For And On Behalf Of The Universit

Detection of disease conditions and comorbidities

A new computational approach may provide improved detection of disease conditions and comorbidities, such as ptsd, parkinson's, alzheimer's, depression, etc. For example, in an embodiment, a computer-implemented method for detecting a disease condition may comprise receiving a plurality of data streams, each data stream representing a measurement of a brain activity comprising physical and chemical phenomena and performing pattern analysis on the plurality of data streams to detect at least one fundamental code unit of a brain code corresponding to a disease condition based on a combination of the plurality of data streams..

Method for improved seizure detection

A method for improved seizure detection includes capturing neural data for a first set of brain regions; calculating inter-region correlations between pairs of the first set of brain regions from the neural data; detecting a period of hyposynchrony from the inter-region correlations; after detecting the period of hyposynchrony, detecting a period of hypersynchrony from the inter-region correlations; and based on a transition from the period of hyposynchrony to the period of hypersynchrony, detecting a first seizure.. .
Sbb Research Group Llc

Brain dysfunction evaluation system, brain dysfunction evaluation method, and program

A system for evaluating the degree of brain dysfunction of a subject, such as a decline in cognitive function, calculates a difference in movement functions between both hands in a coordination movement. The system includes a storage device for storing time-series data on a finger movement task of each of both hands of a test subject acquired by a movement sensor; a data processing device for analyzing the time-series data stored in the storage device; and a display device for displaying an analysis result analyzed by the data processing device.
Hitachi Maxell, Ltd.

Concussive reduction helmet attachment(s) translational axial rotation control and bracing system (tarcbs).

A concussive reduction helmet attachment system which reduces the total area available for acceleration of the head in all axis, specifically designed to provide a measured reduction in accelerative force at the critical moment within the blow. A helmet attachment that reduces the factors that contribute to mechanical transfer of energy to the brain thereby reducing potential traumatic brain injury, concussions and neck compression.

Brain stimulation system and uses thereof

The present disclosure provides devices, systems and methods for enhancing the cognitive activity/ability of a user by providing a watch-only stimulation session with visual features configured to induce stimulation to different brain areas, thereby stimulating a predefined path within the brain of the user.. .
Wize-i Ltd

Methods, systems, and compositions for cell-derived/vesicle-based microrna delivery

Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected micrornas, including but not limited to, mir-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian brain or neurologic injuries and diseases, including in human beings..
Henry Ford Health System

Blood-brain barrier disrupting agents and uses thereof

The present invention relates to blood-brain barrier disrupting agents containing a modified serum albumin comprising serum albumin. The present invention further relates to pharmaceutical compositions comprising said agents and use thereof for the treatment of brain diseases and disorders..
Yeda Research And Development Co. Ltd.

Neuroactive steroids, compositions, and uses thereof

Described herein are steroids of formula (i): and pharmaceutically acceptable salts thereof; wherein r1, r2a, r2b, r3, r4, r5a, r5b, r6, and z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus..
Sage Therapeutics, Inc.

Devices and methods for optimized neuromodulation and their application

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce long-term potentiation (ltp) or long-term depression (ltd). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts.

Variable frequency stimulation therapy method

The disclosure relates to an electrical stimulation therapy method. The method includes applying a variable frequency stimulation pulse to target nerve tissue of the patient suffering from dysfunction of a nerve circuit in the brain selected from the group consisting of motor circuit, associative circuit and limbic circuit, wherein the variable frequency stimulation pulse comprises at least two kinds of electrical stimulation pulse trains at different frequencies; and each of the at least two kinds of alternate electrical stimulation pulse trains in each of the plurality of pulse train periods has a duration in a range from about 0.1 seconds to about 60 minutes.
Tsinghua University

Multi-electrode array for spinal cord epidural stimulation

In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.. .
The Regents Of The University Of California

Methods of fabricating a multi-electrode array for spinal cord epidural stimulation

In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.. .
The Regents Of The University Of California

Polyol-based osmotic polydixylitol polymer gene transporter and use thereof

The present invention relates to polydixylitol polymer based gene transporter (pdxyp) and a preparation method thereof. Further, the present invention relates to a nucleic acid delivery complex where the nucleic acids for treatment are conjugated to the gene transporter and a pharmaceutical composition for gene therapy including the complex as an active ingredient.
Seoul National University R&db Foundation

Longevity enhancement induced by repetitive injections of botulinum toxin (centurion effect)

Described herein is a novel application involving the use of therapeutic or cosmetic formulations of botulinum toxin involving an increase and enhancement of longevity in human subjects. The inventors are physicians who have used this agent for the past 30 years for many indications and has treated a large number of patients for periods of 20-30 years, many over the age of 60 at therapy initiation for medical and aesthetic conditions.

19-nor c3, 3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof

And pharmaceutically acceptable salts thereof; wherein , r1, r2, r3a, r3b, r4a, r4b, r5, r6, and r7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus..

B- and y -diketones and y -hydroxyketones as wnt/ b -catenin signaling pathway activators

Which activates wnt/β-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .

Beta-substituted gamma-amino acids and analogs as chemotherapeutic agents

β-substituted γ-amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres are selective lat1/4f2hc substrates, capable of passing through the blood-brain barrier, and exhibit rapid uptake and retention in tumors expressing the lat1/4f2hc transporter.
Quadriga Biosciences, Inc.

Brain activity measurement device, program, and method

The present invention relates to a brain activity measurement device comprising: a signal acquisition part configured to acquire a signal from a brain of the subject, using three sensors attached to different locations on the surface of the head of a subject; a data extraction part configured to extract, from each of the three signals acquired from respective ones of the sensors, a deep-brain potential signal having a specific frequency band arising from an activity of a deep brain region, and acquire data from the extracted deep-brain potential signal with a sampling period; a correlation value calculation part configured to calculate a correlation value indicative of a correlative relationship among the deep-brain potential signals acquired from each respective sensors, based on a phase relationship among three pieces of time-series data each extracted from the respective sensors by the data extraction part; and an index value calculation part configured to analyze the deep-brain potential signals from the deep brain region, based on the calculated correlation value, to calculate an index value for determining a brain function.. .

Left and right brain recognition

The present application provides a left and right brain recognition method and device, and relates to the field of wearable devices. The method comprises: in response to that a user listens to an audio content meeting a predetermined condition, acquiring first brain electrical information of a first hemisphere of the user; and recognizing that the first hemisphere is a left brain or a right brain according to the first brain electrical information and reference information.
Beijing Zhigu Tech Co., Ltd.

Training device, training method, and program

A training device, which is used to cause a user to be trained to operate an extra part based on a measurement result of user's brain activity, notifies the user of information indicating a degree of activation of a brain area corresponding to the extra part, as information indicating the state of the brain activity of the user who imagines trying to operate the extra part.. .
Seiko Epson Corporation

Coercion resistant authentication system based on neurophysiological responses to music

The present invention discloses a method and system for authentication that is coercion resistant by using music that invokes reproducible neurological responses uniquely to a user in order to authenticate the user. The neurological responses may include neurochemical activities inside the brain and brain waves.
Cal Poly Pomona Foundation, Inc.

Training device, corresponding area specifying method, and program

A training device, which is used to cause a user to be trained to operate an extra part based on a measurement result of user's brain activity, causes the user to view an image in which the extra part is operating.. .
Seiko Epson Corporation

Biomarkers for diagnosis and management of neuro-immunological diseases

Biomarkers associated with neuroimmunological disease are described. The disclosed biomarkers are secreted proteins identified in cerebral spinal fluid (csf) samples of patients with neurological disease.
Montana State University

Presence of phosphorylated tau protein in the skin of neurodegenerative disease and scis, scc, and bcc

The presence of misfolded proteins in the brain is the hallmark of neurodegenerative diseases. Protein aggregates could have systemic expression and might be found in several tissues including the skin.

Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury

Processes and materials are provided for the detection, diagnosis, or determination of the severity of a neurological injury or condition, including traumatic brain injury, multiple-organ injury, stroke, alzeimer's disease, parkinson disease and chronic traumatic encephalopathy (cte). The processes and materials include biomarkers detected or measured in a biological sample such as whole blood, serum, plasma, or csf.
Banyan Biomarkers, Inc.

New in vitro blood-brain barrier model

The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g.
Institut National De La Sante Et De La Recherche Medicale

Splice modulating oligonucleotides and methods of use thereof

A splice modulating oligonucleotide (smo), is provided having a sequence designed to modulate the splicing of a scn8a pre-mrna, wherein the smo sequence specifically binds to a sequence in the scn8a pre-mrna. Certain embodiments of the invention provide methods of using the smos described herein, including methods of treating or preventing epilepsy or a dravet spectrum disorder in subject (e.g., a mammal, e.g., a human), including the administration of an smo or composition described herein to the subject.
Lifesplice Pharma Llc

Generating gabaergic neurons in brains

This document provides methods and materials for generating gabaergic neurons in brains. For example, methods and materials for using nucleic acid encoding a neurod1 polypeptide and nucleic acid encoding a dlx2 polypeptide to trigger glial cells (e.g., ng2 glial cells or astrocytes) within the brain (e.g., striatum) into forming gabaergic neurons (e.g., neurons resembling medium spiny neurons such as darpp32-positive gabaergic neurons) that are functionally integrated into the brain of a living mammal (e.g., a human) are provided..
The Penn State Research Foundation

Method of reducing injury to mammalian cells

A method of inhibiting the binding between n-methyl-d-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the nmda receptor or neuronal protein interaction domain that effect said inhibition of the nmda receptor-neuronal protein interaction.
Nono, Inc.

Treatment of bdnf-related disorders using laquinimod

This application provides for a method of increasing brain-derived neurotrophic factor (bdnf) serum level in a human subject comprising periodically administering to the subject an amount of laquinimod or pharmaceutically acceptable salt thereof effective to increase bdnf serum level in the human subject. The method can further comprise periodically administering to the subject an amount of a second bdnf-increasing agent.
Teva Pharmaceutical Industries, Ltd.

Method of analyzing the brain activity of a subject

The invention concerns a method of analysing the brain activity of a patient performing a given task or in response to an external stimulus, by comparison of standardized data with data in a database, by means of fuzzy logic algorithms.. .
Assistance Publique - Hopitaux De Paris

Impact sensing wearable device and method

A mouth guard, or wearable device, senses impact forces, calculates risk factors for injury, and displays status of risk and potential injury. A mouth guard may be used to identify, treat and prevent exacerbating brain injury.
Merrigon, Llc

Multimodal brain sensing lead

A medical lead with at least a distal portion thereof implantable in the brain of a patient is described, together with methods and systems for using the lead. The lead is provided with at least two sensing modalities (e.g., two or more sensing modalities for measurements of field potential measurements, neuronal single unit activity, neuronal multi unit activity, optical blood volume, optical blood oxygenation, voltammetry and rheoencephalography).
Neuropace, Inc.

Apparatus and brain computer interface

The present disclosure discloses an apparatus for a brain computer interface (bci) including a feature extraction filter trainer for training a feature extraction filter which minimizes an influence of a background brain wave while maximizing a difference between intended brain waves; and a classifier trainer for training a classifier for classifying the intended brain waves by using a feature vector obtained by filtering the intended brain wave at the feature extraction filter. With the apparatus, only the background brain wave is additionally measured, such that previous intended brain wave data can be reused and the brain wave can be classified more quickly and accurately..
Gwangju Institute Of Science And Technology

Training system for a user to troubleshoot problems in an hvac process

A training system is disclosed here for a user to troubleshoot problems in an hvac process by comparing hvac components with human body parts. The training system comprises a self-diagnostic thermostat configured to facilitate a user to compare components in the hvac process to human body parts.

Method of multivariate molecule analysis

A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) dna methylation of tumor suppressor genes; (c) non-coding rna expression (microrna profiling); and (d) long non-coding rna expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary.
Miodx

Cyclic polypeptides for the treatment of heart failure

Or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein x1, x3, x4, x7, x8, x9, x10, x11, x12 and x13 are defined herein. The polypeptides are agonist of the apj receptor.

19-nor neuroactive steroids and methods of use thereof

And pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus..

Cancer therapeutics

This invention relates to compounds that bind to wild-type cbfβ and inhibit cbfβ binding to runx proteins. The potent compounds of the invention inhibit this protein-protein interaction at low micromolar concentrations, using allosteric mechanism to achieve inhibition, displace wild-type cbfβ from runx1 in cells, change occupancy of runx1 on target genes, and alter gene expression of runx1 target genes.
University Of Virginia Patent Foundation

Dendrimer compositions and use in treatment of neurological and cns disorders

A dendrimer formation, such as a pamam dendrimer or a multiarm peg polymeric formulation has been developed for systemic administration to the brain or central nervous system. In the preferred embodiment, the dendrimers are in the form of dendrimer nanoparticles comprising poly(amidoamine) (pamam) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for treatment of one or more symptoms of neurodegenerative, neurodevelopmental or neurological disorders such as rett syndrome or autism spectrum disorders, d6 generation dendrimers provide significantly enhanced uptake into areas of brain injury, providing a means for diagnosis as well, as drug delivery..
Kennedy Krieger Institute, Inc.

Elevated intracranial pressure treatment

Provided is an incretin, or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof, for use in a method of reducing elevated intracranial pressure (icp) in a subject. Methods of reducing elevated icp in a subject may comprise administering an incretin, or analogue thereof, an incretin receptor agonist, an incretin enhancer, or any combination thereof to the subject.
The University Of Birmingham

Method for evaluating nuclear medicine image of head

To provide a technique for evaluating a nuclear medicine brain image, the technique being hardly affected by the difference in the setting of reference regions. An embodiment of the present invention generally includes: setting a reference region on a region corresponding to the scalp in the nuclear medicine brain image; calculating information on a pixel value in the set reference region; and normalizing, using the information, a pixel value of each pixel included in the nuclear medicine brain image or a value obtained from the pixel value, and outputting the normalized value..
Nihon Medi-physics Co., Ltd.

Drug efficacy evaluation assisting system, and drug efficacy evaluation assist information presenting method

Provided herein is a technique for effectively and quantitatively evaluating the symptom improving effect of a treatment given to a subject (patient). The invention provides a technique for diagnosing, evaluating, monitoring, and predicting drug efficacy in individuals (patients) with possible mental disorders such as adhd, autism, and depression.
Jichi Medical University

Controller-based diagnosis and treatment of acquired brain injury and dysfunction

A controller-based apparatus for diagnosis and treatment of a subject with acquired brain injury and dysfunction. Various embodiments of the invention described herein recognize that different body postures affect the autonomic nervous system differently, and therefore various external stimuli may have different therapeutic efficacies when a patient or subject is in each body posture.

Super-pixel detection for wearable diffuse optical tomography

A system includes a wearable head apparatus and an electronic console. The head apparatus is configured to receive resultant light from the head of a subject.
Washington University

Apparatus and a therapeutic and educational exercise for brain development and rehabilitation

The invention relates to a means for targeting and stimulating specific areas of neurodevelopment in the brain. The invention provides a series of three types of cues that enable a user to learn and subsequently perform specific bodily movements and unassisted sounds that are precisely paired to promote growth in certain targeted areas of the brain.

Stimuli-based authentication

A method for stimuli-based authentication includes presenting one or more stimuli to a person. The method includes measuring a brainwave response of the person to the one or more stimuli, and authenticating the person based on the measured brainwave response..
Lenovo Enterprise Solutions (singapore) Pte. Lte.

Method for controlling the displaying of text for aiding reading on a display device, and apparatus adapted for carrying out the method, computer program, and computer readable storage medium

This invention aims to support the reader in the task of reading text on a display device (21). In each case an area in the text to which the gaze is directed (view areas/focus area of the eyes) is highlighted, respectively.
Thomason Licensig

Method for improving memory using ccny inhibitor

The present invention may reveal a ccny-oriented molecular mechanism with respect to learning and memory, help understand causes of brain diseases associated with memory problems, and ultimately be applied in the treatment and diagnosis of brain memory disorders such as dementia.. .

Systems, methods and devices for paired plasticity

Systems, methods and devices for paired training include timing controls so that training and neural stimulation can be provided simultaneously. Paired trainings may include therapies, rehabilitation and performance enhancement training.
The Board Of Regents, The University Of Texas System

Neural interface system

The neural interface system of the preferred embodiments includes an electrode array having a plurality of electrode sites and a carrier that supports the electrode array. The electrode array is coupled to the carrier such that the electrode sites are arranged both circumferentially around the carrier and axially along the carrier.
Medtronic Bakken Research Center B.v.

Reproducible placement of abi electrodes

A method is described for determining an optimal placement location for an auditory brainstem implant (abi) electrode array. A cochlear implant (ci) electrode array is inserted into a patient cochlea, and the abi electrode array is initially placed at an initial placement location on a patient brainstem.
Med-el Elektromedizinische Geraete Gmbh

Electrical stimulation device

An electrical stimulation device is provided. The electrical stimulation device according to one embodiment of the present inventive concept is worn on the head so as to apply electrical stimulation to the brain, and comprises: a frame to be worn on the head; an electrode structure including an electrode part formed of a conductive member and a cover unit formed of an insulating member covering at least a part of the electrode part, and of which one end is connected to the frame; and a patch detachable from the electrode structure and making contact with the head when attached to the electrode structure..
Y-brain Inc.

Methods for treating brain malfunctions

Methods of treating a brain malfunction include obtaining a subject diagnosed with a brain malfunction and reducing eeg frequency of brainwaves in the subject by applying at least one eeg-slowing stimulus to the subject, whereby production of β-amyloid protein in the brain of the subject is reduced and progression of the brain malfunction is halted or slowed.. .

Benzazepin-1-ol-derived pet ligands with high in vivo nmda specificity

The present invention is directed to benzazepin-1-ol-derived compounds for use in the diagnosis of nmda receptor-associated diseases or disorders by positron emission tomography (pet). The invention also relates to a method for the diagnosis of nmda-receptor-associated diseases or disorders by administering to a patient in need of such diagnosis a radioactively labelled compound of the invention in an amount effective for pet imaging of nmda receptors, recording at least one pet scan, and diagnosing an nmda-receptor-associated disease or disorder from an abnormal nmda receptor expression pattern on the pet scan.
University Of Zurich

Methods for diagnosing and treating alzheimer's disease

Methods for diagnosing and treating alzheimer's disease are provided. In particular, methods of restoring blood-brain barrier integrity and/or promoting vascular reversion in a person suffering from alzheimer's disease by administering an anti-angiogenic agent or an agent that is capable of restoring tight junction integrity.

Method for using supplemental vascular endothelial growth factor (vegf) or analog to prevent oxygen induced arrest of vessel growth and disease sequela of premature infant birth

Disclosed herein is a method for administering systemic (e.g., by intravenous injection) supplemental vascular endothelial growth factor (vegf) to premature infants to prevent the disease sequelae and complications including but not limited to retinopathy of prematurity (rop) and/or paraventricular leukomalacia (pvl) and/or bronchopulmonary dysplasia (bpd) associated with premature births. The vegf is administered to the premature infant to produce a physiologic serum vegf level that is substantially similar to the vegf level found in a normally developing fetus in the utero.

Methods for treating nervous system injury and disease

The invention is directed to methods for treating nervous system injury and disease, in particular traumatic brain injury and degenerative nervous system disease. Such methods utilize novel compositions, including but not limited to trophic factor-secreting extraembryonic cells (herein referred to as tse cells), including, but not limited to, amnion-derived multipotent progenitor cells (herein referred to as amp cells) and conditioned media derived therefrom (herein referred to as amnion-derived cellular cytokine solution or accs), each alone or in combination with each other and/or other agents..
Noveome Biotherapeutics, Inc.

Small molecule trail gene induction by normal and tumor cells as an anticancer therapy and tumor cells as an anticancer therapy

Methods and compositions relating to tic10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species.
The Penn State Research Foundation

Intransal delivery of curcumin

The present invention is directed to the intranasal delivery of curcumin adapted so as to target the brain.. .
Depuy Synthes Products, Inc.

Dentally-based concussion sensing system for enhanced detection of brain injuries

A system and related devices for continuous and real-time monitoring and detection of head impact and corresponding trauma. The system may include a passive sensor mounted to a subject's tooth using dental hardware or adhesive so as to harness the firm coupling between the subject's tooth and cranium.
University Of Virginia Patent Foundation

Method and system for brain activity detection

Disclosed are a method and system for brain activity detection. The method is: performing multi-channel synchronous collections of brain electrical signals and cerebral cortex blood oxygen signals simultaneously, and ensuring synchronicity of the collected signals among channels, and collecting said brain electrical signals and said cerebral cortex blood oxygen signals of all locations at the same time.
Institute Of Automation Chinese Academy Of Sciences

Brain mapping system and method thereof

A brain mapping system includes a brain signal acquisition device for collecting brain signals corresponding to different locations of the brain, a stimulator for generating a stimulus based upon a pseudorandom sequence, and a processor for segmenting the brain signals into a plurality of epochs and correlating features extracted from the epochs with the pseudorandom sequence to generate correlation functions, wherein a brain map is constructed by the correlation functions.. .

Knockout mouse, screening substance for suppressing mesial temporal lobe epilepsy, and selecting technique for suppressing mesial temporal lobe epilepsy

Provided are a knockout mouse, a method for screening a substance for suppressing mesial temporal lobe epilepsy, and a method for selecting a technique for suppressing mesial temporal lobe epilepsy. A knockout mouse 30 or more days of age that has lost the function of the girdin gene in at least the nervous tissues and exhibits the phenotypes of (1), (2), and (3) below.
National University Corporation Nagoya University

Biologically compatible mobile communication device

The embodiments of the present disclosure provide positions of one or more speakers and microphones that permit a user to orient the antenna and heat generating elements of a mobile communication device in a location that reduces exposure to rf and/or thermal energy or radiation, including orientations where the antenna of the mobile communication device is positioned further away from a brain of a user than an antenna of a conventional mobile communication device.. .
Geelux Holdings, Ltd.

Biomarkers and methods relating to alzheimer's disease

Alzheimer's disease, the most common cause of dementia in older individuals, is a debilitating neurodegenerative disease for which there is currently no cure. In the past, ad could only be definitively diagnosed by brain biopsy or upon autopsy after a patient died.
King's College London

Mir-96-5p inhibitor and a screening the inhibitor

The present invention provides novel medical means to facilitate glutathione (gsh) synthesis in the brain. These means are mir-96-5p inhibitor increasing gsh expression in the brain and a pharmaceutical composition comprising the mir-96-5p inhibitor and having a preventive and/or therapeutic performance to a disease caused by decrease of gsh amount or depression of gsh activity..
Teikyo University

Methods to produce a human plasma-derived igg preparation enriched in brain disease-related natural iggs

The present invention provides, among other aspects, methods for the manufacture of plasma-derived immunoglobulin g compositions highly enriched for anti-brain disease related protein antibodies (e.g., anti-aβ, anti-rage, and anti-α-synuclein antibodies). Advantageously, the methods provided do not affect the manufacturing processes or capabilities for producing plasma-derived igg therapeutics.
Baxalta Gmbh

Quinazoline scaffold based compounds, pharmaceutical compositions and methods of use thereof

The present invention relates to novel heterocyclic compounds based on a quinazoline scaffold, which bind effectively to the mitochondrial translocator protein (tspo), and counteract cell death processes. These compounds can also stimulate neuronal differentiation.
Technion Research & Development Foundation Ltd.

N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (copd); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as behçet's disease.
Pimco 2664 Limited

Device and blue light modulation of brain inflammation

A device and method are provided for modulating brain inflammation. The device includes a light source positionable at a location adjacent a portion of brain for modulating the inflammation thereof the light source has a first off condition and second on condition wherein the light source generates light having a wavelength in the range of 450-495 nanometers (nm).
Wisconsin Alumni Research Foundation

Brain stimulation tool configuration

A method of configuring a local brain stimulation tool is disclosed. The method comprises: obtaining a reference brain network activity (bna) pattern, and a bna pattern describing a neurophysiological state of the subject, each of the bna patterns having a plurality of nodes and each node representing a brain location and at least one brain wave frequency.
Elminda Ltd.

Methods and stimulation of biological tissue

In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure.
Massachusetts Institute Of Technology

Method and treating restless legs syndrome

Apparatuses and methods are disclosed that may be used to treat one or more restless leg syndrome (rls) symptoms of a patient. One example method may include generating first and second stimulation waveforms using a waveform generator; electrically stimulating at least a portion of a sacral region of the patient, based on the first and second stimulation waveforms, using a number of electrodes; damping or interfering with electrical signals transmitted from the patient's brain to the patient's legs via a femoral nerve of the patient using the electrical stimulation; and reducing the one or more symptoms of rls based on damping or interfering with the electrical signals transmitted from the patient's brain..
Invicta Medical, Inc.

Methods of treating mucopolysaccharidosis iiib (mpsiiib)

Methods for treating the central nervous system (cns) in a human patient with mucopolysaccharidosis (mps) mb who has an intact blood brain barrier, comprising intravenous administration of recombinant naglu.. .
Alexion Pharmaceuticals, Inc.

Nanoparticle modification of human adipose-derived mesenchymal stem cells for treating brain cancer and other neurological diseases

The presently disclosed subject matter provides compositions, methods, and kits for transfecting adipose-derived mesenchymal stem cells (amscs) in freshly extracted adipose tissue using nanoparticles comprising biodegradable polymers self-assembled with nucleic acid molecules. The presently disclosed subject matter also provides methods for treating a neurological disease in a patient in need thereof, the method comprising administering the amscs transfected with the nucleic acid molecules to the patient, wherein the nucleic acid molecules encode one or more bioactive molecules functional in the treatment of a neurological disease, particularly wherein the neurological disease is a brain tumor..
The Johns Hopkins University

Method of treating a cns disorder using a water-soluble histone deacetylase inhibitor

A method of treating a cns disorder. The method comprises providing a water-soluble histone deacetylase inhibitor, and administering the water-soluble histone deactylase inhibitor directly into a brain via convection enhanced delivery..
Renishaw Plc

Therapeutic nanoparticles for accumulation in the brain

Nanoparticles containing a mitochondrial that are capable of crossing the blood-brain barrier and that have a targeting moiety, an antioxidant and an anti-inflammatory agent may be useful for treatment of traumatic brain injury.. .
University Of Georgia Research Foundation, Inc.

Brain shift compensation for catheter trajectory planning

The present invention relates to compensating for brain shift in catheter trajectory planning. First brain shift information is determined from an initial brain image dataset, an initial planning dataset, a patient orientation dataset, and first burr hole dataset.
Brainlab Ag

Modifications to access ports for minimally invasive neuro surgery

An access port or retractor tube provides access through tissue to a surgical site or field, such as at the brain or spine, in a minimally invasive manner. The access port permits a user to clearly view and access the surgical field, including areas medial thereto, in a minimally invasive manner by dilating or separating tissue rather than cutting tissue.

System and etecting slow waves

The present disclosure pertains to a system configured to detect slow waves in a subject during a sleep session. The system generates output signals conveying information related to brain activity of the subject.
Koninklijke Philips N.v.

Electrophysiology measurement and training and remote databased and data analysis measurement method and system

A method and system provides for electrophysiological data analysis in a networked processing environment. The method and system includes receiving, via a networked connection, electrophysiological data of a patient and electronically performing, via at least one network processing device, a data analysis on the electrophysiological data.
Evoke Neuroscience, Inc.

Method and system for identification of source of chronic pain and treatment

A method for identifying and treating a neural pathway associated with chronic pain via nerve stimulation and brain wave monitoring of a mammalian brain includes positioning a probe to stimulate a target nerve, wherein the target nerve is suspected of being a source of chronic pain; delivering a first nerve stimulation from the probe to the target nerve, wherein the first nerve stimulation is sufficient to elicit a chronic pain response in the brain; and monitoring for evoked potential activity in the brain as a result of the first nerve stimulation. The method can also include delivering second and third nerve stimulations to confirm the correct identification of the neural pathway and to treat the chronic pain, respectively.
Avent, Inc.

Wearable device and control method therefor

A wearable device according to an embodiment of the present disclosure of the present inventive concept, which is worn on a user's head to apply an electrical stimulation to a brain or measure brain waves from the brain, comprises: a wearing identification unit for identifying a worn state of the wearable device using a first sensor module detecting the worn state of the wearable device of a user; an electrode unit for applying an electrical stimulation to a user's brain or measuring brain waves from the user's brain; and a control unit for controlling the electrode unit to start the electrical stimulation or a brain wave measurement on the basis of the identification result by the wearing identification unit.. .
Y-brain Inc.

Antenna configuration for mobile communication device

The embodiments of the present disclosure provide positions of an antenna of a mobile communication device in a location that places the antenna at a spaced distance from a user and/or the brain of the user to reduce the amount of rf energy that impinges on the brain of the user when the mobile communication device is in use and held near the face of a user.. .
Geelux Holdings, Ltd.

Method for gestational age estimation and embryonic mutant detection

A method to characterize shape variations in brain ventricles during embryonic growth in mammals, the method including extracting a brain ventricle skeleton from one or more images, calculating a volume profile for the skeleton using the extracted images, partitioning the brain ventricle based on the volume profile along the skeleton, the brain ventricle being partitioned into two lateral ventricles and a main ventricle, the main ventricle being further partitioned into three sub regions, determining volume vectors of the two lateral ventricles and the three sub regions, computing a means square error between the determined computed volume vectors and a pretrained mean volume vector of embryos during different gestational stages, and classifying the embryo to the gestational stage having the lowest mean square error. A method to characterize mutant detection in mammals, the method including acquiring one or more images, computing a volume profile directly along a path of the detected skeleton from the one or more images, aligning the volume profile against a standard profile, and evaluating the volume profile against the standard profile to detect a mutation..
New York University

Lcmv-gp-vsv-pseudotyped vectors and tumor-infiltrating virus-producing cells for the therapy of tumors

The invention relates to recombinant vsv viruses and viral vectors which produce a glycoprotein gp of the lymphocyte choriomeningitis virus (lcmv) instead of the g protein of the vsv, to virus producing cells which produce lcmv-gp-pseudotyped vsv virions, and to the use of said vectors and cells in the therapy of solid tumors, especially brain tumors.. .
Viratherapeutics Gmbh

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Recombinant adeno-associated vectors for targeted treatment

Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope

Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf

The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of brain derived neurotrophic factor (bdnf), in particular, by targeting natural antisense polynucleotides of brain derived neurotrophic factor (bdnf). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of bdnf..
Curna, Inc.

Neurovascular unit(nvu)-on-a-chip and fabricating the same

Provided are a neurovascular unit (nvu)-on-a-chip and a method of fabricating the same, which 3-dimensionally integrates various human brain cells in a microfluidic platform by using a brain cell co-culture technique so as to simulate a similar environment to the human brain in vitro. The nvu-on-a-chip includes an extracellular matrix (ecm) simulation material (70) in a gel state; and at least one channel (75) which passes through the ecm simulation material (70) and perfuses a culture medium, in which the ecm simulation material (70) contains a plurality of types of human brain cells on an outer side of the channel (75), a brain microvessel endothelial cell lining (91) is formed on an inner side of the channel (75), and the plurality of types of human brain cells and the brain microvessel endothelial cell lining (91) contact each other through the channel (75) to simulate a blood brain barrier (bbb) of a human brain and a neurovascular unit (nvu) of the human brain including the bbb..
Korea Institute Of Science And Technology

System and controlling robot by brain electrical signals

A system for controlling a robot by brain electrical signal, includes a screen, an electronic signal detection device, and a host computer. The screen shows a plurality of icons thereon, and the plurality of icons flashes at different frequencies.
Hon Hai Precision Industry Co., Ltd.

Deep brain electrode placement and stimulation based on brown adipose tissue temperature

Systems and methods for deep brain electrode placement and deep brain stimulation (dbs) for treatment of conditions such as obesity are disclosed. In one example approach, during placement of a deep brain stimulating electrode in a target region of the brain of a patient, a temperature of brown adipose tissue (bat) may be monitored, e.g., via a supraclavicular temperature sensor implanted in the patient, and used to identify an optimal location of electrode stimulation which causes an increase in bat temperature.
Oregon Health & Science University

Composition for enhancing memory and learning function and/or cognitive function

Compositions, foods, and medicaments for enhancing memory and learning function and/or cognitive function are provided. Compositions, foods, and medicaments for improving brain function and particularly enhancing memory and learning function and/or cognitive function can be provided by including a peptide including an amino acid sequence set forth in any one of seq id nos 1 to 16 as an active ingredient..
Kirin Kabushiki Kaisha

Methods and compositions for treating pathologies associated with bdnf signaling

A method of treating non-neurodegenerative pathologies associated with derangement in brain-derived neurotrophic factor signaling in the brain stem includes administering to the subject an amount of at least one ampakine effective to increase brain-derived neurotrophic factor nodose sensory neurons of the subject.. .
Case Western Reserve University

Multifunctional polymeric nanoparticle for diagnosis or treatment of cerebral diseases and a preparation method thereof

The present invention relates to a drug delivery system (dds) for crossing the blood-brain barrier (bbb) formed by self-assembly of an amphiphilic block copolymer, comprising a self-assembled structure having an average diameter of 5 nm to 20 nm of a core-shell structure comprising a hydrophobic core and a hydrophilic shell; and a hydrophobic drug supported in the hydrophobic core of the self-assembled structure, a pharmaceutical composition for preventing or treating cerebral diseases comprising the drug delivery system as an active ingredient, and a preparation method of the drug delivery system.. .
Korea Institute Of Science And Technology

Accommodating intraocular lens

An accommodating intraocular lens (aiol) is disclosed herein, that is comprised of a flexible optic and a flexible haptic rim that conforms to the human eye capsule. The spherical or custom shape of the optic is engineered to be maintained during accommodation through the mechanical/optic design of the implant and the interaction between the implant and the naturally occurring position and actuating forces applied through ciliary muscles/zonules/and capsule as the brain senses the need to increase the diopter change or magnification when an object of fixation approaches the eye.

Diagnosis of affective disorders using magnetic resonance spectroscopy neuroimaging

A method for facilitating diagnosis of an affective disorder in a person can include (a) acquiring 1h spectroscopic data to obtain an indicator of total choline (tcho) and creatine (cr) in an area, e.g., the anterior cingulate cortex, of the person's brain; and (b) determining, by a processor and based on the indicator, at least one of (i) a likely diagnosis of bipolar disorder or major depressive disorder, or (ii) a probability of bipolar disorder or major depressive disorder, in the person.. .
University Of Utah Research Foundation

Method and teaching and cognitive enhancement

The present invention is a teaching and learning tool built on the principle that the human sense of touch makes a significant contribution in the visualization of objects. Sighted individuals can produce visual images inside the brain (commonly referred to as the “mind's eye”) via the sense of touch, where we use our minds, rather than our eyes, to visualize concrete objects allowing us to “get a picture” of that object.

Image processing apparatus, image processing method, and computer program product

An image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain a value of an index related to a predetermined disease for each of a plurality of sites included in a brain of a patient, on the basis of a plurality of pieces of medical image data obtained by imaging the brain of the patient at each of a plurality of points in time.
Toshiba Medical Systems Corporation

P97-ids fusion proteins

Provided are fusion proteins between p97 (melanotransferrin) and iduronate-2-sulfatase (ids), and related compositions and methods of use thereof, for instance, to facilitate delivery of ids across the blood-brain barrier (bbb) and/or improve its tissue penetration in cns and/or peripheral tissues, and thereby treat and/or diagnose hunter syndrome (mucopolysaccharidosis type ii; mps ii) and related lysosomal storage disorders, including those having a central nervous system (cns) component.. .
Bioasis Technologies, Inc.

Apigenin analogs, compositions, and methods related thereto

Certain embodiments are directed to apigenin analogues or derivatives. In certain aspects, the derivatives are developed as cystathionine-beta-synthase (cbs) inhibitors.
The Board Of Regents Of The University Of Texas System

Compositions, methods, and systems for the synthesis and use of imaging agents

The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof.
Lantheus Medical Imaging, Inc.

Method of treating cancer using selective estrogen receptor modulators

Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (serm). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a serm..
Duke University

Methods for treating brain injury

The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus.
Oklahoma Medical Research Foundation

System and brain state classification

A method for creating brain-machine interface based on received and filtered brain signals from a subject, classifying the filtered signals to classes of brain states, detecting one brain state from the classified brain states and executing by a machine a command that corresponds to the detected state.. .
Technion Research And Development Foundation Ltd.

Brain computer interface using broadband evoked potentials

Method for processing a brain wave signal (4) obtained from a person using a brain wave detector (5). One or more stimuli are applied to the person in which each of the one or more stimuli comprises a pseudo random noise component modulating the stimulus intensity.
Stichting Katholieke Universiteit

Depression brain computer interface for the quantitative assessment of mood state and for biofeedback for mood alteration

A brain computer interface (bci) system includes an electroencephalogram (eeg) headset and a computing device communicatively coupled to the eeg headset. The computing device includes a memory, a processor and a display device.
Washington University

Mobile terminal and control method therefor

A mobile terminal and a control method therefor are disclosed. The mobile terminal according to one embodiment of the present invention comprises: a brainwave detection unit; a brain wave recognition unit; a display unit; and a control unit, wherein the control unit controls the display unit so as to display a first screen corresponding to a first application currently being executed, controls the brainwave detection unit so as to detect the brain wave, controls the brainwave recognition unit so as to recognize the detected brainwave, on the basis of the first application, and controls the display unit so as to display a second screen which differs from the first screen with respect to at least a part thereof, on the basis of the recognized result of the brainwave..
Lg Electronics Inc.

Blood biomarker for early blood brain barrier disruption in ischemic stroke

Methods and apparatus for determining blood brain barrier (bbb)damage and treating patients who may have suffered from bbb damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood.
Stc.unm

Fungal-specific metalloproteases and uses thereof

The present invention relates to methods of reducing, delaying, preventing and/or inhibiting the progression of a cryptococcus infection into the central nervous system (cns) of a subject by inhibiting the activity of a m36 fungalysin metalloprotease (e.g., mpr1) secreted by the cryptococcus. The invention further provides methods of increasing, promoting and/or enhancing delivery of a therapeutic agent across the blood-brain-barrier, comprising systemically administering the therapeutic agent in conjunction with a m36 fungalysin metalloprotease (e.g., mpr1), or an enzymatically active fragment thereof..
The Regents Of The University Of California

Hcbi, msbi, mssi and cmi sequences as an early marker for the future development of cancer and diseases of the cns and as a target for the treatment and prevention of these diseases

Described are hcbi (healthy cattle blood isolate), msbi (multiple sclerosis brain isolate), mssi (multiple sclerosis serum isolate) and cmi (cow milk isolate) nucleotide sequences as well as probes and primers comprising part of said nucleotide sequences and antibodies against polypeptides encoded by said nucleotide sequences. Said compounds are useful as early markers for the future development of cancer and diseases of the cns (multiple sclerosis ms, prion-linked diseases, amyotrophic lateral sclerosis, transmissible spongiforme encephalitis, parkinson's disease, alzheimer disease) and should represent targets for treatment and prevention..
Deutsches Krebsforschungszentrum

Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system

The present invention provides compounds and compositions which are positive allosteric modulators of gaba-a receptors that selectively target the peripheral nervous system and organs of the body, and which do not pass through the blood-brain barrier. The compounds and compositions of the present invention are useful for treatment of diseases or disorders which are mediated by gaba-a neuronal activity, such as, for example, visceral pain, gut motility, irritable bowel syndrome, functional abdominal pain, functional idiopathic diarrhea, inflammatory bowel diseases, drug induced pain, bile salt malabsorption, lactase or other carbohydrate intolerance..
Lieber Institute, Inc.

Image-guided irrigating suction cannula for removal of intracerebral hemorrhage and other lesions

A minimally invasive surgery device for image-guided removal of lesions in the brain by providing suction and irrigation through a small cranial opening. One particular use is for evacuation of intracerebral hemorrhage.
The Regents Of The University Of California

Nanoparticle contrast agent for early diagnosis of alzheimer's disease by magnetic resonance imaging (mri)

The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (mri). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing alzheimer's disease at an early stage..
The Chinese University Of Hong Kong

Compositions and methods for the repair of myelin

Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.. .
Duke University

Preparation and application of flavonol as brain-targeting synergist

The present invention discloses a preparation and application of flavonol as a brain-targeting synergist. After long-term repeated studies, the inventors have found that some flavonol compounds, particularly kaempferide, rutin, troxerutin, myricetin, hesperidin, and hydroxy derivatives thereof, in particular their glycoside, ester, ether derivatives, can promote the drug molecules that have therapeutic or healthcare effect, such as ginsenoside, stilbene glucoside, resveratrol, levodopa, edaravone, vinpocetine, nicergoline, citicoline, oxiracetam, to enter brain tissues, to dramatically enhance drugs concentrations in the brain tissues and effective enhance the efficacy of drugs without increasing the plasma concentration..
Guangdong Pharmaceutical University

Continuous administration of levodopa and/or dopa decarboxylase inhibitors and compositions for same

Disclosed herein are for example, liquid aqueous compositions that include for example an ester or salt of levodopa, or an ester or salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, parkinson's disease, secondary parkinsonism, huntington's disease, parkinson's like syndrome, psp, msa, als, shy-drager syndrome, dystonia, and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of levodopa and/or carbidopa or ester and/or salt thereof.. .
Neuroderm, Ltd.

Frequency-multiplexed speech-sound stimuli for hierarchical neural characterization of speech processing

A system and method for generating frequency-multiplexed synthetic sound-speech stimuli and for detecting and analyzing electrical brain activity of a subject in response to the stimuli. Frequency-multiplexing of speech copora and synthetic sounds helps the composite sound to blend into a single auditory object.
The Regents Of The University Of California

Method and fixation, alignment, and/or saccadic measurements to identify and/or track brain function

A device can include a body having a top surface, an opposing bottom surface, a first face and an opposing second face. The first face can have an opening therein.
Rebiscan, Inc.

Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using electrodes with microvoltammetry

The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, parkinson's disease, brain injuries, spinal cord injuries, and cancer.
New York University School Of Medicine

Helmet to reduce traumatic brain injuries

A protective helmet includes a plurality of fluid filled bladders, impact sensors, valves, and pumps wherein the helmet absorbs energy from an impact to protect a person wearing the helmet from traumatic brain injury. The bladders expel fluid in response to a triggering event such as energy from an impact detected as a pressure spike event and/or detected as an acceleration event.

Methods and detecting and handling split brain issues in a link aggregation group

Methods and apparatus for operating a virtual node in a lag that includes a first virtual node and a second virtual node are disclosed. The first virtual node includes at least a first fellow node and a second fellow node.
Telefonaktiebolaget Lm Ericsson (publ)

System for the distributed collection of brain health information

A system is provided for collecting medical data about a subject between visits to a health care professional. The system includes a medical records database that stores patient data for access by the health care professional and an interactive and distributed data collection system provided to a team of collaborators (doctors, parents, teachers, etc.) who are to collect data about the subject between visits to a health professional.
Cerora, Inc..

Method for a brain region location and shape prediction

A volumetric segmentation method is disclosed for brain region analysis, in particular but not limited to, regions of the basal ganglia such as the subthalamic nucleus (stn). This serves for visualization and localization within the sub-cortical region of the basal ganglia, as an example of prediction of a region of interest for deep brain stimulation procedures.
Surgical Information Sciences, Inc.

Method and system for supporting a medical brian mapping procedure

A data processing method performed by a computer for supporting a medical brain mapping procedure, comprising the steps of receiving a microscope image of a patient's cortex and superimposing stimulation response marks onto the microscope image, wherein a stimulation response mark indicates the patient's response to an electrical stimulation of the cortex by a stimulation probe at a position associated with the stimulation response mark.. .
Brainlab Ag

Metabolic biomarkers of autism

This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein.
Stemina Biomarker Discovery, Inc.

5-ala for detection of brain tumors

The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ala) and detecting the conversion of 5-ala to protoporphyrin ix (ppix) associated with brain-derived microparticles.. .
Pioma, Inc.

Conditionally active biological proteins

This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at some physiological conditions. For example, conditionally active biologic proteins are active in tumors, but virtually inactive at other body parts, or conditionally active antibodies cap able of crossing blood-brain-barrier..
Bioatla, Llc

Novel compositions useful in treating brain-related diseases or disorders and methods using same

The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
Drexel University

Device and low-noise magnetic neurostimulation

The present invention relates to a device and a method for the stimulation of nerve and muscle cells according to the principle of magnetic stimulation, wherein the invention has a significantly reduced sound emission for the same stimulus intensity when compared to the prior art. The sound emission in the form of a click noise, which, in the magnetic stimulation, determines on the one hand an important safety risk and on the other hand causes an undesired, uncontrollable sensory-auditory brain stimulation is reduced in the present invention by increasing the frequency of a substantial portion of the spectrum of the pulse, preferably up to or beyond the human hearing range.

Transcranial magnetic lesioning of the nervous system for relief of intractable pain

Intractable pain is a horrific cause of world-wide suffering. Nervous system excitation is a hallmark of intractable pain and lesioning of excited pathways and structures can produce sustained analgesia.

Method and system for treating patients with alzheimer disease

A method and system for treating patients with alzheimer disease includes steps and equipment operative for subjecting a patient suffering from alzheimer disease to a non-invasive action directed toward a patient's brain and causing a cavitation process in the patient's brain liquid in the vicinity of lesions and thereby destroying the latter.. .

Method and virtual reality-based mindfulness therapy

In one embodiment, there is a computer-implemented method for delivering therapy to a user, comprising: providing data representative of an initial sensory stimulus to a sensory stimulus device and causing the sensory stimulus device to provide the initial sensory stimulus to the user; receiving alpha wave biometric data of the user from a brain electrical activity sensor while the sensory stimulus device provides the initial sensory stimulus; determining whether the alpha wave biometric data meets sensory stimulus adjustment criteria; if the alpha wave biometric data meets sensory stimulus adjustment criteria, adjusting the sensory stimulus provided to the user by providing data representative of an adjusted sensory stimulus to the sensory stimulus device and causing the sensory stimulus device to provide the adjusted sensory stimulus; and if the alpha wave biometric data fails to meet sensory stimulus adjustment criteria, continue causing the sensory stimulus device to provide the initial sensory stimulus to the user.. .
Cigna Intellectual Property, Inc.

Controlled release delivery system for nasal applications and treatment

This invention relates to a gel formulation for nasal administration of a controlled release formulation of hormones to the systemic circulation and/or to the brain. The special lipophilic or partly lipophilic system of the invention leads to higher bioavailability of the active ingredient caused by sustained scrum levels in plasma but also leads to a more favorable serum level profile.
Mattern Pharma Ag

Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin

Compositions tor prevention or treatment of non-inflammatory neuronal damage from brain trauma and strokes are provided, and the compositions contain a therapeutically effective amount of a compound selected from the group consisting of menthol, linalool, icilin and combinations thereof. Methods for treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes are also provided, and the methods include administering such compositions..
Nestec S.a.

Compositions and methods for minimizing or reversing agonist-induced desensitization

Methods and compositions are provided for preventing or reversing loss of the therapeutic effect of a drug, where the loss is associated with the repeated administration of the drug to a patient. The method includes administering to the patient a dopamine receptor agonist or partial agonist or a drug that increases the extracellular level of dopamine by enhancing release of dopamine, decreasing the removal of dopamine from the extracellular space, enhancing the synthesis of dopamine within the brain, or decreasing metabolic degradation of dopamine; and also administering to the patient an opioid receptor antagonist in an ultra-low dose amount, wherein the ultra-low dose amount is effective to prevent or reverse loss of therapeutic effects associated with the repeated administration of the drug to the patient.
Pharmorx Therapeutics, Inc.

Compounds for treating brain cancer

For use in the treatment of a brain cancer selected from a mgmt positive astrocytic brain tumor, a metastatic brain cancer and primary cns lymphoma and a method of treating said brain cancers in a patient in need thereof comprising administering to the patient said compound of formula i or a pharmacologically acceptable salt thereof.. .

Improved embolic protection device and method

A catheter device is disclosed comprising; an elongate sheath (503) with a lumen and a distal end for positioning at a heart valve (6), an embolic protection device (200) for temporarily positioning in the aortic arch for deflection of embolic debris from the ascending aorta to the descending aorta, said embolic protection device is connectable to a transluminal delivery unit (130) extending proximally from a connection point (131), and having: a frame with a periphery, a blood permeable unit within said periphery for preventing embolic particles from passing therethrough with a blood flow downstream an aortic valve into side vessels of said aortic arch to the brain of a patient, and at least one tissue apposition sustaining unit (300, 350) extending from said catheter, into said aortic arch, and being attached to said embolic protection device at a sustaining point (502), for application of a stabilization force offset to said connection point at said embolic protection device, such as at said periphery, and for providing said stabilization force towards an inner wall of said aortic arch, away from said heart, and in a direction perpendicular to a longitudinal extension of said periphery, when said catheter device is positioned in said aortic arch, such that tissue apposition of said periphery to an inner wall of said aortic arch is supported by said force for improving stability and peripheral sealing. In addition related methods are disclosed..
Swat Medical Ab

Method for treating aortic arch diseases

In a method for treating an aortic arch disease, after an intraoperative stent is expanded in an aorta and at least one arch branch vessel, and before the vessel is exactly anastomosed with an incision, by blocking a thoracic aorta between the incision and an arch branch vessel closest to the incision, the intraoperative stent in the thoracic aorta is also blocked, so that blood is prevented from flowing from the incision, and a proximal orifice of the intraoperative stent, and the low body perfusion may be recovered in advance, thereby reducing the circulatory arrest time of the low body perfusion and reducing the time of ischemia of visceral organs and lower limbs of a patient. Meanwhile, the flow of a cerebral perfusion through the right axillary artery may be recovered to a normal flow in advance, and the time of ischemia of the brain of the patient is reduced..
Lifetech Scientific (shenzhen) Co., Ltd.

Eeg glasses (electroencephalographic eyewear)

This invention comprises eeg glasses (electroencephalographic eyewear) with a side section of an eyewear frame which spans forward and upward onto a portion of the person's forehead and then curves back downward to connect to the front section of the eyewear frame. These eeg glasses (electroencephalographic eyewear) further include a flexible protrusion which is attached to the side section and an electromagnetic energy sensor which collects data concerning electromagnetic brain activity, wherein the flexible protrusion holds the electromagnetic energy sensor..
Medibotics Llc

Brain-computer interface for facilitating direct selection of multiple-choice answers and the identification of state changes

Methods, systems, apparatus, and non-transitory computer readable media are disclosed utilizing brain-computer interfaces (bcis). Various embodiments are disclosed to allow a user to directly select multiple-choice answers, to provide motorized wheelchair controls, and to allow a user to play a game via the bci.
The Regents Of The University Of Michigan

System and methods for neurological monitoring and assisted diagnosis

Methods and systems for assessing brain activity and collecting information related to a subject's condition and brain electrical activity are provided. The methods and systems include collecting and transferring data related to the neurological state of a subject.
Brainscope Company, Inc.

Content evaluation system and content evaluation method using the system

A reliable content evaluation method and system are disclosed. The system includes a brainwave detector, a bio signal detector, a first controller, and a second controller.
Nhn Entertainment Corporation

Linear velocity imaging tomography

The invention describes a new imaging modality based on linear velocity imaging tomography; its applications include differentiating between malignant and benign tissues, the ability to correlate an ecg trace with actual disorders of the heart and imaging brain communications.. .

Apparatus for detecting and providing brain signals by use of electroencephalography

Apparatus for monitoring a brain signal, especially indicative of muscle fatigue, comprises at least three sensors sensing neuronal activity, wherein one sensor (11) comprises a reference electrode and the other sensors (15, 16) comprise sensing electrodes, wherein the reference sensor (11) serves as a common reference for the other sensors (15, 16). The reference sensor (11) is placed within the quadrangle defined by the four positions [f5-f1-c 1-c5] or on a corridor of 10 millimetres width along the line between fpz to oz, the first sensing sensor is placed within the quadrangle [c1-c2-p2-p1], and the second sensing sensor is placed within the quadrangle [ft7-fc3-cp3-tp7], with the proviso that the reference electrode is not positioned on the same position as is one of the two sensing sensors and wherein the positions of the sensors delimiting the quadrangles are defined according to the 10-10 electrode placement system of the american clinical neurophysiology society..
Squipe Gmbh

Helmet extension connected to shoulder pad to prevent brain and spine injuries

A helmet supported by a vertical extension, extending from the rear-center of the helmet to the rear-center of shoulder pads or shoulder harness. The fixed in-place helmet is supported above the wearer's head, without relying upon the wearer for support, and permits the wearer to move his head in all directions.





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