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Brain patents

      

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Automatic 3d brain tumor segmentation and classification
A fully automatic brain tumor segmentation and classification method and system improve the healthcare experience with machine intelligence. The automatic brain tumor segmentation and classification method and system utilize whole tumor segmentation and multi-class tumor segmentation to provide accurate analysis..
Sony Corporation


Novel compounds as rearranged during transfection (ret) inhibitors
This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .
Glaxosmithkline Intellectual Property Development Limited


Implantable medical device for providing chronic condition therapy and acute condition therapy using vagus nerve stimulation
Disclosed herein are methods, systems, and apparatus for treating a medical condition in a patient using an implantable medical device (imd). The imd is capable of generating a first electrical signal for treating a medical condition, for example epilepsy.
Cyberonics, Inc.


Organic compounds
The present invention relates to novel pyridinoxy phenylpropanamines, their pharmaceutical compositions and methods of use. In addition, the present invention relates to therapeutic methods that penetrate the blood-brain barrier and regulate the norepinephrine and serotonin transporters (“net/sert”)..
Intra-cellular Therapies, Inc.


Therapeutic agents containing cannabis flavonoid derivatives targeting kinases, sirtuins and oncogenic agents for the treatment of cancers
An embodiment of the invention provides a cannabis-based flavonoid pharmaceutical composition including any one or more selected, from among the group of apigenin, cannflavin. A.
Flavocure Biotech Llc


Item of headwear for cooling the head
Headwear for cooling the neurocranium region of a user's head and thereby the user's brain. In particular, the headwear provides selective cooling to specific areas of the parietal region, the frontal region, the temporal region and the occipital region of the cranium associated with the drainage system of the brain following a traumatic injury..

Brain connectivity analysis system and brain connectivity analysis method
Provided is a technique for comprehensively understanding the relationship between brain regions. A brain connectivity analysis system herein includes a memory configured to have stored therein a connectivity analysis program for analyzing the connectivity; and a processor configured to read the connectivity analysis program from the memory and analyze the connectivity.
Hitachi, Ltd.


System and temporal and spatial detection of seizure onset
Many electrodes are positioned inside a skull for obtaining several electric voltage variation wave information. A processing unit computes subtract operation between two neighboring electrical voltage variation wave information respectively and then can obtain electrical voltage difference waves.
Chung Shan Medical University Hospital


Brain-protecting helmet lining apparatus and method
A brain-protecting helmet lining apparatus and method providing pad liners made of a viscoelastic material which deforms in a time-dependent and nonlinear way, and has a capability of storing strain energy when deformed, while dissipating some energy through hysteresis, where, in use, the viscoelastic material will deform, under slight pressure applied consistently, to closely fit the user's head and prevent unwanted movement of the head within the helmet, but upon the application of strain over a short pulse of time from a blow or checked momentum, the viscoelastic material will resist deformation which would loosen the fit to the user's head, and will store and partially dissipate the strain energy, protecting the head and brain of the user.. .

Method and system for automated brain tumor diagnosis using image classification
A method and system for classifying tissue endomicroscopy images are disclosed. Local feature descriptors are extracted from an endomicroscopy image.
Siemens Aktiengesellschaft


Methods of in vitro differentiation of midbrain dopamine (mda) neurons

The presently disclosed subject matter provides for in vitro methods of inducing differentiation of human stem cells into midbrain dopamine neurons, and precursors thereof, and cells generated by such methods. The presently disclosed subject matter also provides for uses of such cells for treating neurodegenerative disorders..
Memorial Sloan-kettering Cancer Center

Progesterone phosphate analogs and uses related thereto

This disclosure relates to progesterone phophate derivatives and uses related thereto. In certain embodiments, the disclosure relates to compounds disclosed herein and uses for managing inflammation such as those resulting from traumatic brain injury or stroke..
Emory University

Biological co-processor (bcp)

Embodiments may provide a general-purpose, relatively inexpensive, ai-driven implant that is able to adapt to and modulate any given neuron, circuit, or region in the brain, as well as individual cells of any type of tissue. For example, in an embodiment, a method for interacting with living tissue may comprise attaching a device to a body of a person or animal, the device comprising plurality of carbon fibers in contact with the living tissue, receiving by the carbon fibers signals from the living tissue, processing the received signals by the device, and transmitting the processed signals..

Devices, delivering coffee-derived volatiles

Devices, systems and methods are provided for delivering coffee-derived volatiles to a user, particularly for the treatment of addiction. The coffee volatiles are selected and delivered by devices and systems which allow for concentrated delivery to the olfactory system of the user in a controlled manner.

Endoscope handle with a rigid surgical suction for endoscopic micro-neurosurgery of the brain

A handle for endoscope for two handed micro neurosurgery of the brain comprising adjustable rigid surgical suction, channel for endoscope, surgical suction control hole.. .

Novel methods of use of tetrahydroberberine (thb)

Tetrahydroberberine (thb), isolated from the chinese herb “corydalis ambigua”, exhibits a variety of pharmacological effects, although mechanisms of action are unclear or entirely unknown. Described herein are novel methods of using tetrahydroberberine (thb), thb analogs or derivatives, tetrahydroprotoberberines (thpb).
Dignity Health

Unitary multilumen cranial bolt

A unitary multilumen cranial bolt for use in multimodal monitoring of a plurality of physiological parameters in brain tissue incorporates a plurality of lumens, each lumen directing a catheter borne sensor through a bore hole in the cranium and into brain tissue of a patient. The lumens are configured to cause the catheters to splay outward as they enter the cranial cavity and reach their intended depth of penetration.
Thermal Technologies, Inc.

Suggest activities according to the dominant nostril

brain activity, and in particular which hemisphere is relatively more effective, is correlated with the dominant nostril (i.e., the nostril through which most of the air is exhaled when breathing through the nose). Since each side of the brain plays a different role in different types of activities, it may be better to conduct certain activities when a certain nostril is dominant.
Facense Ltd.

Method for estimating perceptual semantic content by analysis of brain activity

A perceptual semantic content estimation method includes: (a) inputting, to data processing means, brain activity induced in a subject by a training stimulation and detected as an output of a brain activity detection means and an annotation of a perceptual content; (b) associating a sematic space representation of the training stimulation and the output of the brain activity detection means in a stored semantic space and storing the association in a training result information storage means; (c) inputting, to the data processing means, an output when the brain activity detection means detects brain activity induced by a novel stimulation, and obtaining a probability distribution in the semantic space which represents perceptual semantic contents for the output of the novel stimulation-induced brain activity by the brain activity detection means on the basis of the association; and (d) estimating a highly probable perceptual semantic content on the basis of the probability distribution.. .
National Institute Of Information And Communications Technology

Method for determining the perceptiveness of a subject

The perceptive faculties of a subject are determined by way of a brain-computer interface 20. At least two mutually distinguishable types of stimuli sa, sb which are applicable to a subject are prescribed.

Identify the dominant nostril using thermal measurements

brain activity, and in particular which hemisphere is relatively more effective, is correlated with the dominant nostril (i.e., the nostril through which most of the air is exhaled when breathing through the nose). Thus, identifying which of the nostrils is dominant may have various applications.
Facense Ltd.

Image classification by brain computer interface

A method of classifying an image is disclosed. The method comprises: applying a computer vision procedure to the image to detect therein candidate image regions suspected as being occupied by a target; presenting to an observer each candidate image region as a visual stimulus, while collecting neurophysiological signals from a brain of the observer; processing the neurophysiological signals to identify a neurophysiological event indicative of a detection of the target by the observer; and determining an existence of the target in the image is based, at least in part, on the identification of the neurophysiological event..
Innereye Ltd.

Methods for inducing neurogenesis

A method for inducing neurogenesis in the brain of a mammal includes administering a light treatment from an led light source.. .
The Litebook Company Ltd.

Brain stimulation programming

A programming system allows a user to program therapy parameter values for therapy delivered by a medical device by specifying a desired therapeutic outcome. In an example, the programming system presents a model of a brain network associated with a patient condition to the user.
Medtronic, Inc.

Adaptive deep brain stimulation using frequency sub-bands

Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes.
Medtronic, Inc.

Adaptive deep brain stimulation using movement desynchronization

Techniques are disclosed for delivering electrical stimulation therapy to a patient. In one example, a medical system delivers electrical stimulation therapy to a tissue of the patient via electrodes.
Medtronic, Inc.

Skull implanted electrode assembly for brain stimulation

A skull-implantable electrode assembly for delivering pulses of electric current to a patient's brain, comprising an electrode housed in an insulated conduit and threaded through an electrically-conductive cannulated skull screw. Details of the exterior construction are discussed, as well as electrode arrangements and methods of treating a medical ailment of a patient..
King Abdullah International Medical Research Center

Adaptive deep brain stimulation using homeostatic window

Techniques are disclosed for defining a homeostatic window for controlling delivery of electrical stimulation therapy to a patient. In one example, a method includes generating and delivering electrical stimulation therapy to tissue of a patient via electrodes.
Medtronic, Inc.

Compositions for mitigating head trauma

Compositions and methods and provided for preventing or mitigating the effects of traumatic brain injuries, such as concussions. The compositions comprises between 100-11500 mg docosahexaenoic acid (dha), 100-3000 mg curcumin, and 100-3000 mg of resveratrol.

Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity

Chemical syntheses and medical uses of novel inhibitors of the uptake of monoamine neurotransmitters and pharmaceutically acceptable salts and prodrugs thereof, for the treatment and/or management of psychotropic disorders, anxiety disorder, generalized anxiety disorder, depression, post-traumatic stress disorder, obsessive-compulsive disorder, panic disorder, hot flashes, senile dementia, migraine, hepatopulmonary syndrome, chronic pain, nociceptive pain, neuropathic pain, painful diabetic retinopathy, bipolar depression, obstructive sleep apnea, psychiatric disorders, premenstrual dysphoric disorder, social phobia, social anxiety disorder, urinary incontinence, anorexia, bulimia nervosa, obesity, ischemia, head injury, calcium overload in brain cells, drug dependence, and/or premature ejaculation are described.. .
Auspex Pharmaceuticals, Inc.

Access sheath for brain surgery

A surgical sheath system for performing surgery of the head includes a flexible tubular braided sheath which is radially expandable. An expansion tube is insertable into the sheath to radially expand the sheath.
Spiway Llc

Robotic guide for brain biopsy

Various robotic guides for a biopsy surgical tool are disclosed, of which one includes a main shaft, an end-effector mounted on a distal end of the main shaft, a roll/yaw actuating mechanism, a translational actuating mechanism, and a pitch actuating mechanism. Optionally, the roll/yaw actuating mechanism includes a first actuating mechanism and a second actuating mechanism.
Parseh Intelligent Surgical System

Automated detection of spreading depolarizations

Computer-implemented methods and automated systems for real-time detection of spreading depolarizations in a brain injured patient, based an algorithm of (a) providing a reference data base of spreading depolarization waveform templates generated from eeg recordings of confirmed spreading depolarizations (sd) in a reference brain-injured patient cohort; (b) recording an eeg of the brain injured patient to generate recorded eeg waveforms; (c) detecting a slow potential change present in a recorded eeg waveform by applying a power spectral density estimate to the recorded waveform; (d) comparing a detected spc to a reference database of sd waveform template to identify a candidate sd; and (e) rejecting a candidate sd as a false positive based on overall signal power and amplitude analysis and identifying a non-rejected candidate sd as a detected sd.. .
University Of Cincinnati

System and automatic prediction and prevention of migraine and/or epilepsy

The present invention relates to the field of detecting/preventing migraine attacks. In particular, a system and method for detecting and preventing a migraine episode in a user are provided.
Koninklijke Philips N.v.

Method and information retrieval

This disclosure relates to methods and apparatus for generating criteria for information retrieval tasks. A quantifying unit is trained through machine learning to assign relevance values to functional brain imaging potentials measured from a person.
Helsingin Yliopisto

Preventing split-brain scenario in a high-availability cluster

As disclosed herein is a tool for preventing split-brain scenario, including determining, by a processor, that a first node of a ha cluster is unable to communicate with a second node of the ha cluster, and initiating, by a processor, by the first node, a handshake operation with a connected client, wherein the handshake operation comprises requesting that the client determine a status of the second node and receiving, from the client, a response indicating the status of the second node. Further, accepting, by a processor, new requests in response to determining that the second node is unavailable, and requesting, by a processor, restoration of communications between the first node and the second node in response to determining that the second node is available..
International Business Machines Corporation

Preventing split-brain scenario in a high-availability cluster

As disclosed herein is a tool for preventing split-brain scenario, including determining, by a processor, that a first node of a ha cluster is unable to communicate with a second node of the ha cluster, and initiating, by a processor, by the first node, a handshake operation with a connected client, wherein the handshake operation comprises requesting that the client determine a status of the second node and receiving, from the client, a response indicating the status of the second node. Further, accepting, by a processor, new requests in response to determining that the second node is unavailable, and requesting, by a processor, restoration of communications between the first node and the second node in response to determining that the second node is available..
International Business Machines Corporation

Wearable electronic, multi-sensory, human/machine, human/human interfaces

A wearable haptic humaxi/machine interface (hhmi) receives electrical activity from muscles and nerves of a user. An electrical signal is determined having characteristics based on the received electrical activity.

Hybrid computer interface system

A hybrid system is used to perform screen object manipulation and or external device control. In a first portion of the hybrid system a single camera is used to provide the tracking of a user's pupil.

Regulatory brain specific ctyoplasmic rnas (bc rnas) and methods of use thereof in diagnosis and treatment of neuropsychiatric lupus

Compositions and methods for diagnosing an increased risk of npsle are provided.. .
The Research Foundation For State University Of New York

Time-varying magnetic field therapy using multistable latching mechanisms

The invention provides wearable devices for effecting transcranial magnetic stimulation to be used by patients who have suffered brain injuries. Permanent magnets are shifted or rotated to deliver a time-varying magnetic field, preferably about the locus of the injury.
Rhode Island Board Of Education, State Of Rhode Island And Providence Plantations

System and neurostimulation

A brain stimulation method and system are provided, wherein neuronal signals of a patient are continuously sensed by at least one sensor device and based on the sensed signals, stimulation signals are applied to the patient by at least one stimulation device, wherein the sensed signals are transmitted to a body-external, portable processing device wherein the sensed signals are evaluated, and based on the evaluated signals stimulation control signals are generated and transmitted to the stimulation device where based on the stimulation control signals the stimulation signals are generated.. .
C/o Cortec Gmbh

Visual prosthesis employing virtual neural electrode arrays

The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain.
Precision Neuro Technologies Llc

Providing sensory stimulation based on slow wave periodicity

The present disclosure pertains to a system configured to provide sensory stimulation to a subject (12) during a sleep session. The system includes one or more sensory stimulators (16) configured to provide sensory stimulation to the subject; one or more sensors (18) configured to generate output signals conveying information related to brain activity of the subject; and one or more processors (20) configured to detect individual slow waves in the subject; control the one or more sensory stimulators to provide sensory stimulation to the subject based on the detected individual slow waves; predict a timing for occurrence of a predicted slow wave based on the previously detected individual slow waves; and responsive to not detecting the predicted slow wave at the predicted timing control the one or more sensory stimulators to provide sensory stimulation at the predicted timing for occurrence of the predicted slow wave..
Koninklijke Philips N.v.

Method for lowering thyrotropin levels in adults

The inventor has discovered that a particular dosage of alpha glycerylphosphoryl choline administered to adult males results in a reduction of thyrotropin serum. Thytotropin levels are depressed with increased dopamine levels in the brain, and cdp-choline has been shown to increase dopamine and dopamine receptor density in the cns.
University Of Louisiana At Lafayette

Medicinal agent and beverage/food for preventing cerebral dysfunction and improvidng same

Provided is method for improving depression of a patient by administering to a patient suffering from depression an effective dose of sepiapterin or a pharmaceutically acceptable salt of sepiapterin in an amount from 0.1 to 100 mg/kg of body weight per day. The sepiapterin or salt of sepiapterin entering the patient's bloodstream and passing the patient's blood-brain barrier to enter a neuron, and the sepiapterin or salt of sepiapterin converting to tetrahydrobiopterin in a neuron of the brain and the tetrahydrobiopterin facilitating biosynthesis of an aromatic monoamine in the patient's brain to provide an elevated level of an aromatic monoamine in the patient's brain to improve depression of the patient.

Calculation of perfusion parameters in medical imaging

A method of determining a residue function in brain tissue, from medical images acquired after introducing contrast agent into the blood, correcting for contrast agent leakage into the tissue, comprising: a) providing time signals indicating contrast agent concentration for leaking voxels, a time signal indicating average contrast agent concentration for non-leaking voxels, and an artery input function, all derived from the images; b) fitting the leaking voxel signals to a model time signal with a free parameter for leakage rate, the model assuming that the concentration of contrast agent perfusing through a leaking voxel has a same shape as a function of time as the average contrast agent concentration for non-leaking voxels; c) using the best fit leakage rate parameter to make a correction for leakage to the leaking voxel signals; and d) deconvolving the corrected signals from the artery input function, to find the residue function.. .
Algotec Systems Ltd.

Wearable brain sensors

A wearable apparatus for wearing on a head of a user, the apparatus has a band assembly comprising an outer band member comprising outer band ends joined by a curved outer band portion of a curve generally shaped to correspond to the users forehead; a flexible inner band member comprising inner band ends joined by a curved inner band portion of a curve generally shaped to correspond to the user's forehead, the inner band member is attached to the outer band member at least by each inner band end respectively attached to a respective one of the outer band ends; at least one brainwave sensor disposed inwardly along the curved inner band portion to provide a flexible conductive surface; and a deformable attachment that connects the flexible inner band member to the outer band, the deformable attachment allowing the inner band to conform to the user's forehead shape, the deformable attachment having a biasing component to urge the at the at least one brainwave sensor towards the user's forehead when worn by the user.. .
Interaxon Inc.

Stress detection method and apparatus

Embodiments of the present disclosure provide techniques and configurations for an apparatus for stress event detection. In some embodiments, the apparatus may be a wearable device and may include at least one first sensor disposed on the wearable apparatus to generate a first sensor signal indicative of a brain activity of a user, at least one second sensor disposed on the wearable apparatus to generate a second sensor signal indicative of a heart rate of the user, and at least one third sensor disposed on the wearable apparatus to generate a third sensor signal indicative of a respiration rate of the user.
Intel Corporation

Method and monitoring an organ of a patient

An apparatus for determining tissue versus fluid components of an organ include a detector that generates a detector signal based on electrical signals derived from tissue and fluid. The apparatus includes a signal processor in communication with the detector which subtracts in real time a tissue component from the detector signal and produces a fluid volume signal.
Board Of Regents, The University Of Texas System

Head-mounted electrode array

A headset for defecting brain electrical activity may include a flexible substrate having first and second ends each configured to engage an ear of a subject and dimensioned to fit across the forehead of a subject. The headset may also include a plurality of electrodes disposed on the substrate and configured to contact the subject when the headset is positioned on the subject.
Brainscope Company, Inc

Brain activity detection system, devices and methods utilizing the same

brain activity detection technologies are disclosed. In some embodiments the technologies include a brain activity detection system that includes a sensor block including that includes at least one reference electrode and at least one sense electrode.
Intel Corporation

Label-free single and multi-photon fluorescence spectroscopy to detect brain disorders and disease: alzheimer, parkinson and autism from brain tissue, cells, spinal fluid and body fluids

A label free single or multi-photon optical spectroscopy for measuring the differences between the levels of fluorophores from tryptophan, collagen, reduced nicotinamide adenine dinucleotide (nadh), and flavins exist in brain samples from a of alzheimer's disease (ad) and in normal (n) brain samples with label-free fluorescence spectroscopy. Relative quantities of these molecules are shown by the spectral profiles of the ad and n brain samples at excitation wavelengths 266 nm, 300 nm, and 400 nm.

Systems, methods, and devices having stretchable integrated circuitry for sensing and delivering therapy

System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a the brain, or the surface of the heart.
Mc10, Inc.

3d imaging

A three-dimensional (3d) imaging method and device, generating a 3d image by only one imaging apparatus. The imaging apparatus is configured to perform the following three functions: converting source light to linear polarized light (s11), transforming, by faraday effect, the linear polarized light into mixed polarized light comprising two polarized lights having different polarization directions (s12), and displaying, according to the mixed polarized light, an image (s13).
Guangzhou Uc Network Technology Co., Ltd.

Metabolomics profiling of central nervous system injury

A method of diagnosing central nervous system injuries such as acquired brain injury (abi) and/or acquired spinal cord injury (asi), including mild tbi (concussion or blast wave), mild asi (contusion, stretch or partial cord transection), non-tbi brain injury and/or non-tsi spinal cord injury in a subject (animal or human). The method includes (a) obtaining a biological test sample from the subject, identifying metabolites in the subject's sample using metabolomics thereby obtaining a subject's metabolite matrix and generating a subject's profile using the patient's metabolite matrix; and (b) using multivariate statistical analysis and machine learning to compare the subject's profile with predetermined set of profiles of cns injuries and a predetermined set of profiles of controls to determine if the subject has a cns injury..
London Health Sciences Centre Research Inc.

Recombinant protein-based the delivery of silencer rna to target the brain

The present invention relates to the design and development of recombinant protein for the delivery of silencer rna complex to mediate rna interference since it represents a novel therapeutic approach to modulate several neurodegenerative disease-related genes across the blood-brain barrier (bbb). To overcome challenges due to this barrier for biologics and other biological complex, the present invention describes a method wherein peptide having sequence gggghlnilstlwkyrc represented by seq id no.
Council Of Scientific & Industrial Research

System and operating remote controlled toys using brainwaves

A system and method for controlling a remote control assembly with precision using signals detected by low-cost brainwave sensors. A brainwave detection unit senses brainwaves and produces corresponding data signals.

Coil use in transcranial magnetic stimulation increasing current generated by induced electric field

A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided in which the coil apparatus includes a coil arranged to oppose a surface of a head of a human to generate a current by an induced electric field in a magnetic stimulation-target region in a brain by electromagnetic induction, and to stimulate neurons. The coil apparatus includes the coil configured by winding a conductive wire along a predetermined reference surface; and a magnetic body arranged between the head and the coil to oppose the coil, and arranged at a position at an opposite side of the head.
Osaka University

Magnetic stimulation coils and ferromagnetic components for reduced surface stimulation and improved treatment depth

A tms device may include treatment coils and ferromagnetic components that are configured to be disposed proximate to corresponding ones of the treatment coils. The treatment coils and ferromagnetic components of the tms device may cooperatively generate a magnetic field that exhibits one or more characteristics that differ from those of a magnetic field that is generated by the treatment coils alone.
Neuronetics, Inc.

Wireless midfield systems and methods

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University

Identification of compromised components in a medical system

In some examples of selecting a target therapy delivery site for treating a patient condition, a relatively high frequency electrical stimulation signal is delivered to at least two areas within a first region (e.g., an anterior nucleus of the thalamus) of a brain of a patient, and changes in brain activity (e.g., as indicated by bioelectrical brain signals) within a second region (e.g., a hippocampus) of the brain of the patient in response to the delivered stimulation are determined. The target therapy delivery site, an electrode combination, or both, may be selected based on the changes in brain activity..
Medtronic, Inc.

Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrilary tangles

Or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (pet) imaging to study tau deposits in brain in vivo to allow diagnosis of alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.

Intranasal administration of guanidinylated aminoglycosides

This disclosure relates to intranasal administration of conjugates comprising guanidinylated aminoglycosides (“guanidinoglycosides”) and a polypeptide (e.g., an enzyme, antibody, or polypeptide growth factor). For example, such administration methods are useful for delivering a polypeptide to the brain and/or cerebrospinal fluid.
The Regents Of The University Of California

Methods of treating cognitive impairments or dysfunction

The present disclosure provides methods for treating one or more of cognitive deficits or cognitive impairments associated with or caused by mild brain injuries, chemotherapy treatment, chemotherapy medication, post-chemotherapy cognitive impairment (pcci), chemo brain, and other disorders arising from cognitive dysfunction in a subject by administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant.. .
Oxeia Biopharmaceuticals, Inc.

Brain, spinal, and nerve injury treatment

A treatment for brain, spinal and nerve injury comprising use of a substance p receptor antagonist optionally in combination with a magnesium compound. There is also provided a formulation for use in this treatment comprising a substance p receptor antagonist and a magnesium compound..
Eustralis Pharmaceuticals Limited

Compositions and methods for treating microbiota-related psychotropic conditions and diseases

In alternative embodiments, the invention provides compositions and methods for treating, ameliorating and preventing various disorders and conditions in manunals, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor, for example, where the microbial or bacterial flora of the bowel manufactures neurotoxins or neurotoxic agents that enter the body through the gastrointestinal (01) tract, e.g. The colon, and reach the systemic space, e.g., by neural streaming or via the circulation, to reach the central nervous system (cns), including the brain, the peripheral nervous system (pns), and other nervous systems.

Catheter with jet impingement cooled thermoelectric module

Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about −15° c. To about −30° c.
Berger Thermal Research Ltd.

Helmet omnidirectional energy management systems

An embodiment of a safety helmet for protecting the human head against repetitive impacts, moderate impacts and severe impacts so as to significantly reduce the likelihood of both translational and rotational brain injury and concussions includes an outer shell, an outer liner disposed within and coupled to the outer shell, and an inner liner disposed within and coupled in spaced opposition to the outer liner by a plurality of isolation dampers for omnidirectional movement of the inner liner relative to the outer liner and the outer shell.. .
6d Helmets, Llc

Blood brain barrier models and methods to generate and use the same

The present disclosure generally relates to a process to prepare a cell culture system that mimics the structure of blood brain barrier (bbb) and are useful to study the functions thereof. In particular, the present invention relates to a direct-contact coculture and triculture systems prepared by plating bmecs on a pre-formed lawn of coculture of astrocytes and pericytes on the apical surface of a culture-chamber to achieve a truly direct contact triculture model for bbb.
Purdue Research Foundation

Dna-methylation based classifying tumor species

The present invention pertains to methods for classifying tumorous diseases based on their specific genomic dna methylation profile. The invention provides a method that allows for a classification of a tumor sample obtained from a patient by analysing a multitude, preferably genome wide, collection of cpg positions by comparison to a classification rule derived from a set of methylation data acquired from pre-classified tumor species.
Ruprecht-karls-universität Heidelberg

Widespread gene delivery to motor neurons using peripheral injection of aav vectors

The present invention relates to compositions and methods, in particular to methods based on systemic injection of raav, for delivering genes to cells of the central nervous system in mammals, such as brain neurons or glial cells, and in particular to motor neurons or glial cells of the spinal cord the invention also relates to methods of treating motor neuron disorders in mammals by expression of therapeutic genes. The invention stems from the unexpected discovery that peripheral injection of aav vectors leads to a bypass of the blood brain barrier and a massive infection of motor neurons.
Centre National De La Recherche Scientifique

1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives and 1,1,1-trifluoro-4-hydroxybutan-2-yl carbamate derivatives as magl inhibitors

And pharmaceutically acceptable salts thereof; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds or salts, and their uses for treating magl-mediated diseases and disorders including, e.g., pain, an inflammatory disorder, traumatic brain injury, depression, anxiety, alzheimer's disease, a metabolic disorder, stroke, or cancer.. .

Ultrasonic stimulation device using guide framework

A guide framework for positioning an ultrasonic transducer which emits a focused ultrasound to a target point in carrying out surgery to apply ultrasonic stimulation to a subject's brain, includes a body in a shape of a mask that is laid on the subject's face, and a positioning hole formed through an inner surface and an outer surface of the mask body, the positioning hole into which the ultrasonic transducer is inserted, wherein the inner surface of the mask body is formed to conform a facial contour of the subject, and when the guide framework is laid on the subject's face and the ultrasonic transducer is disposed at the positioning hole, the position of the target point is naturally disposed at a preset stimulation site of the brain. An ultrasonic stimulation device includes an ultrasonic transducer and the guide framework for positioning the ultrasonic transducer..
Korea Institute Of Science And Technology

Central base coils for deep transcranial magnetic stimulation

A transcranial magnetic stimulation coil which is location-specific for medial brain regions or lateral brain regions is designed with multiple spaced apart stimulating elements having current flow in a first direction, and multiple return elements having current flow in a second direction which is opposite the first direction. The multiple stimulating elements are distributed around a central axis of the coil..
Brainsway Ltd.

Method of correlating brain activity

The present invention includes systems and methods of using real-time neurofeedback to improve the correspondence between first-person experience and specific brain activation patterns in a manner that minimally affects the experience itself. The present invention provides meditators the ability to enhance their control over their own brain activity, such as posterior cingulate cortex (pcc) activation.
Yale University

Compositions of medicinal plants for reducing the effects of aging, prevention and treatment of age-related neurodegenerative diseases, and treatment of anxiety and sleep disorders

Compositions comprising extracts prepared from mixtures of the herbal plants radix bupleurum chinense dc (“b”), rhizoma corydalis yanhusuo wt wang (“y”), caulis polygonum multiflorum thunb (“p”) and flos albizia julibrissin durazz (“a”) are provided. The byp, bya, bpa, by, bp, yp and bypa extracts significantly decreased one or more of the effects of accelerated aging in mice exposed to d-galactose, including spatial memory deficit, and elevated oxidative stress marker malondialdehyde and pro-inflammatory cytokines tnf-alpha and il-6 in the brain, indicating efficacy in reducing the damage of aging, and preventing and treating alzheimer's disease and/or parkinson's disease.
Pharmacogenetics Limited

Nutritional composition with human milk oligosaccharides and uses thereof

The present disclosure generally relates to pediatric nutritional compositions including a human milk oligosaccharide or a precursor thereof. Further, the nutritional compositions may include a prebiotic mixture of galacto-oligosaccharide and/or polydextrose, a probiotic, such as lactobacillus rhamnosus gg, and human milk oligosaccharides.
Mead Johnson Nutrition Company

Small molecule therapeutic compounds that reduce the incidence of intracerebral hemorrhage and brain microhemorrhages

The described invention relates to small molecule therapeutic compounds capable of reducing the incidence of intracerebral hemorrhage and brain microhemorrhages identified using zebrafish and mouse models of intracerebral hemorrhage and brain microhemorrhages.. .
St. Michaels Hospital

Modeling blood-brain barrier in vitro

Synthetic human blood vessels can be constructed using human brain derived endothelial cells and incorporated into a tissue model that contains astrocytes and other neurons and microglia. Multi-cell type microvessels incorporate cell types such as astrocytes and pericytes in order to construct a highly representative blood-brain barrier in vitro model with a functional lumen containing brain-derived microvascular endothelial cells and a polymer wall containing human astrocytes and/or pericytes..
The Government Of The United States Of America, As Represented By The Secretary Of The Navy

Methods of protecting against brain injury

The present disclosure provides methods of maintaining brain function, memory function and reducing the prevalence of mild traumatic brain injury in an individual at risk of experiencing a mild traumatic brain injury. The present disclosure also provides methods for administering various human dietary supplements to individuals at risk of experiencing a mild traumatic brain injury..
Natural Alternatives International, Inc.

Composition comprising siallyllactose for use in enhancing learning skills and memory function

This invention relates to the use of a nutritional composition comprising sialylated oligosaccharides for enhancing cognitive development and learning skills in mammals. The nutritional composition comprises 3′-siallylactose (3′-sl) and 6′-siallylactose (6′-sl) in a weight ratio between 10:1 and 1:10 and is specifically for use in enhancing learning skills and/or enhancing memory function in an individual by increasing the sialic acid (neu5ac) concentration in the brain of said individual..
Nestec S.a.

Development of spinal cord on a microfluidic chip

The invention relates to culturing brain endothelial cells, and optionally astrocytes and neurons in a fluidic device under conditions whereby the cells mimic the structure and function of the blood brain barrier. Culture of such cells in a microfluidic device, whether alone or in combination with other cells, drives maturation and/or differentiation further than existing systems..
Cedars-sinai Medical Center

Blood brain barrier transport molecules and uses thereof

The disclosure provides transporter molecules capable of carrying agents of interest across the blood brain barrier. Also provided are polynucleotides encoding transporter molecules, methods making transporter molecules, and methods of using transporter molecules, e.g., for the diagnosis, prevention, or treatment of central nervous system diseases, disorders, or injuries..
Medimmune Limited

Dicam-specific antibodies and uses thereof

Novel antibodies directed against dual ig domain containing cell adhesion molecule (dicam) are described. These anti-dicam antibodies are capable of detecting dicam by western blot and/or flow cytometry, blocking the interaction between dicam and its ligand αvβ3 integrin, and/or blocking the migration of inflammatory cytokine-secreting th17 lymphocytes across the blood brain barrier.
Centre Hospitalier De L'université De Montréal

Ang (1-7) derivative oligopeptides and methods for using and producing the same

The present invention provides oligopeptides, in particular, ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/of impairment..
Arizona Board Of Regents On Behalf Of The University Of Arizona

Inhibitors of dual leucine zipper (dlk) kinase for the treatment of disease

Disclosed herein are compounds which inhibit the kinase activity of dual leucine zipper (dlk) kinase (map3k12), pharmaceutical compositions, and methods of treatment of dlk-mediated diseases, such as neurological diseases that result from traumatic injury to central nervous system and peripheral nervous system neurons (e.g. Stroke, traumatic brain injury, spinal cord injury), or that result from a chronic neurodegenerative condition (e.g.
Board Of Regents, The University Of Texas System

Skull implanted magnet assembly for brain stimulation

A skull-implantable magnet assembly for delivering a static magnetic field to a patient's brain, comprising a rod-shaped magnet housed within a skull screw, removably attached to a casing housing at least one flat magnet, is described. Details of the exterior construction are discussed, as well as magnet arrangements and methods of treating a brain tumor or neurological ailment of a patient..
King Abdullah International Medical Research Center

Therapy device with current titration

An ect system capable of focusing the electrical signals on a specific portion of the patient's brain is provided. The ect system includes a means of applying unidirectional electrical signals and asymmetric electrodes for focusing the signals on the patient.
Mecta Corporation

Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord

The invention provides an expression system for producing caveolin-1 in neuronal cells or neural stem cells comprising a neuron-specific regulatory element and a nucleic acid sequence encoding caveolin-1.. .
The Regents Of The University Of California

Regulation of brain biogenic amines associated with depression by a formulation from botanical source

Provided herein are anti depressant and anxiolytic herbal formulations including: 225-450 mg of nyctanthes arbortristis, 250-550 mg ocimum tenuiflorum, 200-450 mg hippophae salcifolia, and optionally additives selected from minerals, vitamins, salt, filler and binder. Also provided are methods of making such formulations and methods of using such formulations for treating or improving brain function..

Treatment for ischemic stroke

Granulocyte colony-stimulating factor (g-csf; a stem cell enhancer and facilitator), detc-meso (a glutamate receptor partial antagonist and anti-excitotoxicity agent), and sulindac (a potent anti-oxidant and anti-inflammatory agent) each can protect brain tissue exposed to a cerebral ischemia/reperfusion injury, and minimize the size of infarcts that develop as a result of the injury. When administered in combination, these agents are effective at protecting brain tissue and minimizing the size of an infarct resulting from the injury at much lower concentrations compared to using a single agent..
Chs Pharma, Inc.

System and assessing electrical activity using an iterative sparse technique

Three-dimensional electrical source imaging of electrical activity in a biological system (e.g., brain or heart) may involve sensor array recording, at multiple locations, of signals (e.g. Electrical or magnetic signals) of electrical activity.
Regents Of The University Of Minnesota

Transmission transmitting brain parameter sensor data

The result is a transmission apparatus which is designed for use in a domestic patient environment.. .

Method for training and development of craft skills

A method of learning is provided that is dedicated to advancing the expertise of participants in a workforce by utilizing advanced cognitive processes that deepen mastery of complex subject matter. The method is designed to deliver brain-based, customized learning activities that utilize multiple senses and educational touch points.
Society Of Cable Telecommunications Engineers, Inc.

Volition and visual enhancing processes embedded in wearable device

The interaction of human functions and internet data assisted by a wearable computational device that allows direct volition manifestation over internet links on offer employing eye tracking web navigation technology is a brain empowering revolution. A wearable computational device that incorporates a video camera that feeds life video of our surroundings back to the user of this device has resolved the natural human limitation to multitask while on the move.

Apparatus and detecting brain fingerprint using causal connectivity of brainwave

When a brain fingerprint is detected, a predetermined visual stimuli is output on a screen of a display, causal connectivity formed by unique eeg signals of a subject between two or more brain regions from among a predetermined plurality of brain regions is detected on the basis of the eeg signals of the subject who selectively attends to a part corresponding to a letter or symbol conceived by the subject from among the visual stimuli output on the screen of the display, an activation pattern of causal connectivity between brain regions is recognized on the basis of the detected causal connectivity, and the subject is identified by using the recognized unique activation pattern of causal connectivity between brain regions as a brain fingerprint.. .
Korea University Research And Business Foundation

Systems and methods for monitoring of blood lactate and targeting of blood lactate via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Methods for differentiating pluripotent cells

Methods are provided, in some aspects, for differentiating pluripotent cells into midbrain dopaminergic (da) neurons using a mono-smad inhibition or inhibition of smad signaling with only one smad inhibitor. In some embodiments, mono-smad inhibition utilizes a single inhibitor of bone morphogenic protein (bmp) for differentiating pluripotent cells into midbrain da neurons..
Cellular Dynamics International, Inc.

19-nor neuroactive steroids and methods of use thereof

Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to formula (1): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, and status epilepticus..
Sage Therapeutics, Inc.

Composition and treating metabolic disorders

Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of metabolic disorders, including prediabetes, obesity, insulin resistance, hyperinsulinemia, hyperglycemia and type 2 diabetes mellitus (t2dm) and/or, e.g., the treatment of other medical disorder(s) including immune or endocrine disorders or diseases. Bromocriptine citrate is administered over a limited or extended period at a time of day dependent on re-establishing the normal circadian rhythm of central dopaminergic activity of healthy members of a similar species and sex.
Veroscience Llc

Immunotherapy compositions and methods for treatment of tauopathy and transgenic mouse

This disclosure describes, in one aspect, immunogens effective for treating and/or diagnosing tauopathy, and immunotherapeutic compositions and methods involving those immunogens. Generally, the immunogen includes an antigen presentation component and a microtubule-associated tau protein (mapt) component linked to at least a portion of the antigen presentation component.
Stc. Unm

Topical regional neuro-affective therapy with caryophyllene

A method of treating a disease state or condition in humans via topical brainstem afferent stimulation therapy via the administration of caryophyllene to the back of the neck of a human patient to provide regional neuro-affective therapy is disclosed. In certain embodiments, the drugs are incorporated into a pharmaceutically acceptable topical carrier, e.g., a cream, gel, lotion or foam..
Afgin Pharma, Llc

System and noninvasive identification of cognitive and behavioral goals

A brain machine interface system for use with an electroencephalogram to identify a behavioral intent of a person is disclosed. The system includes an electroencephalogram configured to sense electromagnetic signals generated by a brain of a person.
Teledyne Scientific & Imaging, Llc

Stroke catheter for use in revascularization procedures and using same

A method of removing vascular blockage includes providing a catheter system, comprising an outer catheter, a bypass catheter, and a guidewire. In the catheter system, the bypass catheter is slidably disposed within the outer catheter.

Sleep tracking systems, methods, and devices

Provided are mechanisms and processes for tracking sleep. Devices may include an accelerometer configured to measure macro and micro sensitivity movement of head, movement of throb of vessels close to the ear, monitor changes in heart rate and pulse rate and blood pressure.

Diagnostic brain injury based on emg frequency power spectra analysis

A method and a device for diagnosing brain injury (e.g. Concussion) based on analysis of electromyogram (emg) signals and presence of neurological modulation impairment of motor activity are described.

Dynamic display customizing a controller in a display system

A method, or corresponding dynamic display system, for customizing a controller of a display system includes presenting a visual stimulus to a subject at at least one known location relative to the subject's eye gaze; measuring brain activity of the subject's left and right brain hemispheres in response to the subject's viewing of the stimulus; processing the measured brain activity to determine a frequency-dependent metric of the measured brain activity; assessing independent cognitive capacities of the subject's left and right brain hemispheres based on the frequency-dependent metric; and adjusting a function of the controller in the display system according to the assessed independent capacities, such as by adjusting the function to change a stimulus load in a visual hemifield according to the brain activity in the contralateral brain hemisphere. Example applications include head-up display (hud), augmented reality (ar) or virtual reality (vr) display systems, and brain injury assessment systems..
Massachusetts Institute Of Technology

Shear-thickening fluid cowl for cervical spine protection

The described invention, shear-thickening fluid cowl for cervical spine protection, is a hollow hood connected to the wearer's helmet and rear body-armor plate. It is composed of baffles and shear-thickening fluid.

Generation of an inducible pericyte-specific cre mouse model

Pericytes are mural cells of brain capillaries that degenerate in multiple neurological disorders. Pericytes regulate neurovascular functions, but their role in the adult brain and disease is still poorly understood because of the lack of adequate pericyte-specific experimental models.
University Of Southern California

Impact-driven traumatic brain injury testing apparatus

The present invention provides an apparatus and methods to quantitatively measure a physical perturbation to a human head model by a mechanical impact of a blunt trauma. The apparatus is configured to obtain a set of non-contact measurement data from the human head model upon the mechanical impact.

Biguanide compound and use thereof

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence even with small doses, and may thus be effectively used in preventing or treating various cancers such as uterine cancer, breast cancer, stomach cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, liver cancer, etc., inhibiting cancer cell proliferation and cancer metastasis..
Immunomet Therapeutics Inc.

Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors

Systemic administration of intact, bacterially derived minicells results in rapid accumulation of the minicells in the microenvironment of a brain tumor, in therapeutically significant concentrations, without requiring endothelial endocytosis/transcytosis across the blood brain barrier or any other mechanism by which, pursuant to conventional approaches, nanoparticles have entered into that microenvironment. Accordingly, a wide variety of brain tumors, both primary and metastatic, can be treated by administering systemically a therapeutically effective amount of a composition comprised of a plurality of such minicells, each minicell being a vehicle for an active agent against the tumor, such as a radionuclide, a functional nucleic acid or a plasmid encoding one, or a chemotherapeutic agent..
Engeneic Molecular Delivery Pty Ltd

Recombinant glut1 adeno-associated viral vector constructs and related methods for restoring glut1 expression

The present invention relates to recombinant glut1 adeno-associated viral vector (raav) constructs and related methods for restoring glut1 expression in glut1 deficient mammals. In certain embodiments, the raav further comprises a chicken β-actin promoter wherein the raav is capable of crossing the blood-brain barrier (bbb).
University Of Massachusetts

Human cord blood as a source of neural tissue repair of the brain and spinal cord

The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to treat neurodegenerative diseases of the brain and spinal cord..
Saneron Ccel Therapeutics, Inc.

Phosphodiesterase inhibitors to repair brain and/or retinal injury in human newborns

The present disclosure concerns the use of a phosphodiesterase inhibitor, such as, for example, sildenafil, to repair a brain and/or a retinal injury in a newborn. The phosphodiesterase inhibitor can be used in a premature or a term baby that has been exposed to hyperoxia or hypoxia which caused a brain and/or a retinal injury..

Method of treating a brain tumor

Disclosed herein are methods of treating a brain tumor by administering plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by administering plinabulin..
Beyondspring Pharmaceuticals, Inc.

System and intraoperative characterization of brain function using input from a touch panel device

Systems and methods are provided for performing an intraoperative assessment of brain function based on input that is obtained using a touch panel device, in response to a task, and in the presence of an intervention that is applied to a selected region of the brain. The intervention may be stimulation of the selected region of the brain, such as direct cortical stimulation.
Providence St Joseph's And St Michael's Healthcare

Wireless wearable brain blood-oxygen monitoring system

The wireless wearable brain blood-oxygen monitoring system provided by the present application comprises a monitoring control device, a detection device, a fixing device and a flexible printed circuit board; said monitoring control device is used for processing a first optical signal to generate a digital signal and sending said digital signal to a portable mobile terminal; said detection device is used for receiving the first optical signal sent by said monitoring control device, and calculating a degree of blood-oxygen saturation in a detected area according to an incident light intensity and an emergent light intensity of the first optical signal; said flexible printed circuit board is used for fixing a photoelectric conversion means in said detection device; said fixing device is used for fitting said monitoring control device and said detection device to the forehead. The present application can make the brain blood-oxygen monitoring system to monitor in real time and can make it portable..
Institute Of Automation Chinese Academy Of Sciences

Intraoperative guidance system for tumor surgery

The current invention pertains to a system and methods of identifying a site in a tissue of a patient as neoplastic or normal. The system comprises a source of electromagnetic signals; an optical probe which delivers the electromagnetic signals to a working end of the probe; a spectrometer which acquires diffuse reflectance electromagnetic signals returned from the site probed by the optical probe.
The Florida International University Board Of Trustees

Method and stimulating stereoscopic depth perception of stereoscopic data inside head mounted displays when viewing panoramic immersive stereoscopic content

Apparatuses and methods are provided that stimulate realistic 3d depth perception from 3d image data. The solution helps the brain perceive a more realistic depth by placing an object, which may or may not be transparent, in virtual 3d space such that the object appears close to the user inside the panoramic viewer in order to give the brain a close point to reference in 3d space where it might normally struggle to perceive depth at the border of two opposing perceptions of 3d depth for the brain..

Apparatus for augmenting human vision

The functional effect of having additional color-sensing cone types in the human eye is implemented by an encoding of some spectral information differently for the left and right eyes. This different encoding for identical features seen by the left and right eyes is interpreted as a perceptively different feature by the human brain, allowing additional spectral information to be conveyed through the limited tristimulus sensitivity of the human eye..
Wisconsin Alumni Research Foundation

Brain actuated control utilizing visually evoked potentials

A brain-to-computer interface providing brain actuated control of hardware or software associated with said computer is effected by releasably attaching a plurality of high-impedance dry ag/ag—cl electrodes to selected locations on a human user's scalp; providing a low-noise, high-gain, instrumentation amplifier electrically associated with said plurality of electrodes; utilizing a high-resolution analog-to-digital (a/d) converter electrically associated with said instrumentation amplifier and said computer to digitize electroencephalographic signals detected by said plurality of electrodes; and, analyzing said digitized electroencephalographic signals utilizing a computer algorithm to detect steady-state evoked potentials in response to visual stimuli for use in providing control inputs to said hardware or software.. .

Diagnostic pediatric acute-onset neuropsychiatric syndrome (pans) and pediatric autoimmune neuropsychiatric disorder associated with streptococci infection (pandas)

The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (pans) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (pandas) in an individual. These include enzyme linked immunosorbent assays (elisas) to measure antibody titers against neuronal antigens present in the brain; the neuronal antigens include lysoganglioside, tubulin, dopamine receptor d1, dopamine receptor d2, serotonin receptor 5ht2a, and serotonin receptor 5ht2c.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv

Epcam aptamers and conjugates thereof

The present disclosure relates to an epcam aptamer or an epcam aptamer conjugate having bi-functional activity and to uses thereof. In particular, the present disclosure also relates to an aptamer conjugate which binds to the transferrin receptor (tfr) and epcam which is useful for treatment of brain tumours and/or brain metastasis..
Deakin University

Vaccines for preventing meningococcal infections

The present invention stems from the finding that the interaction between the β2 adrenoceptor (β2ap) and type iv pilus-associated proteins initiates a process leading to the opening of the blood brain barrier. The invention therefore pertains to a vaccine for preventing the spreading of meningococci into the meningeal space, wherein said vaccine allows the production of antibodies inhibiting the interaction between the type iv pilus-associated proteins and the β2ap..
Universite Paris Descartes

Prodrugs riluzole and their use

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process..
Biohaven Pharmaceutical Holding Company Ltd.

N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and their therapeutic use

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e.g., diseases) including, inflammation and/or joint destruction and/or bone loss; disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; inflammatory and autoimmune disorders, for example, rheumatoid arthritis; psoriasis; psoriatic arthritis; chronic obstructive pulmonary disease (copd); asthma; atherosclerosis; inflammatory bowel disease; ankylosing spondylitis; multiple sclerosis; systemic lupus erythematosus; sjogren's syndrome; a disorder associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, or paget's disease; cancer, such as a haematological malignancy, such as multiple myeloma, leukemia, or lymphoma, or a solid tumour cancer, such as bladder cancer, breast cancer (female and/or male), colon cancer, renal cell carcinoma, kidney cancer, lung cancer, pancreatic cancer, gastric cancer, prostate cancer, brain cancer, skin cancer, thyroid cancer, basal cell ameloblastoma, or melanoma; a disorder associated with fibrosis, such as systemic sclerosis or scleroderma; or a rare vasculitide, such as behçet's disease.
Pimco 2664 Limited

High-resolution brain machine interface with magnetically-responsive array switches coupled to an internal antenna

A neuronal tissue-machine interface apparatus includes an array of magnetically-responsive switches positioned in close proximity or contact to neuronal tissue of a human subject, wherein a magnetic environment of the plurality of magnetically-responsive switches varies along the array, and an antenna that is electrically connected to the array, wherein a subset of the magnetically-responsive switches respond to electromagnetic energy received by the antenna, and wherein the response of the subset of the magnetically-responsive switches includes modulation of an electrical current conducted by the subset of the magnetically-responsive switches.. .
Weinberg Medical Physics, Inc.

Delivery of polynucleotides using recombinant aav9

The present invention relates to adeno-associated virus 9 methods and materials useful for systemically delivering polynucleotides across the blood brain barrier. Accordingly, the present invention also relates to methods and materials useful for systemically delivering polynucleotides to the central and peripheral nervous systems.
Nationwide Children's Hospital

Methods for enhancing the delivery of molecules across the blood brain barrier

The present invention relates to methods and compositions for enhancing the delivery of an agent across the blood brain barrier utilizing a composition comprising an inhibitor of pikfyve.. .
Lam Therapeutics, Inc.

Composition for preventing, ameliorating, or treating neurological disease containing osmotin peptide as active ingredient

A method of preventing or treating neurological disease includes administering to a subject in need thereof, a composition comprising an osmotin peptide selected from the group consisting of (a) an osmotin peptide having the amino acid sequence of seq id no: 1, and (b) an osmotin peptide having at least one amino acid residue substitution, deletion or insertion in the amino acid sequence of seq id no: 1. When a subject is treated with the osmotin peptide, nerve cells show no increase in growth rate, have little cytotoxicity, and suppress cell death, and when the osmotin peptide is administered to an animal model, the osmotin peptide infiltrated into the hippocampus of the brain and the hypothalamus of the brain, which is the deep part of the brain.
Industry-academic Cooperation Foundation Gyeongsang National University

Riluzole prodrugs and their use

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process..
Biohaven Pharmaceutical Holding Company Ltd.

A protecting against carbonyl stress induced ischemia-reperfusion injury in the diabetic brain via administration of n-acetylcysteine

A method for one of preventing and minimizing diabetes pathology in a mammal, comprising administering to the mammal an effective amount of n-acetylcysteine (nac).. .
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College

Systems and methods for in vivo detection of electrophysiological and electrochemical signals

Systems and methods for measuring electrophysiological and electrochemical signals in a portion of a body of a subject are provided. The structure includes an array of electrochemical sensors made of miniaturized multi-layer graphene, an array of electrophysiological electrodes, an integrated front-end readout circuit, and narrow silicon shafts with metal spines.
New York University

Physiological phantoms incorporating feedback sensors and sensing materials

Disclosed herein are physiological phantoms incorporating sensors and sensor materials integrated with a tissue phantom of an anatomical part. The sensors and sensor materials include small diameter optical fibers containing bragg gratings, thermochromic materials, electrical strain gauges, flexible strain gauges, shape sensing cables, electrochromic materials and etc.

A novel nervous system-specific transmembrane proteasome complex that modulates neuronal signaling through extracellular signaling via brain activity peptides

The inventors surprisingly found that neural stimulation caused the synthesis and degradation of proteins into peptides which were then secreted into the cell media within minutes of stimulation by a novel neural-specific and membrane bound proteasome (neuronal membrane proteasome or nmp) that is transmembrane in nature. These secreted, activity-induced, proteasomal peptides (snapps) range in size from about 500 daltons to about 3000 daltons.
The Johns Hopkins University

Detecting dementia and alzheimer's disease associated biomarkers stabilized on solid support materials

Embodiments of the invention provides a method for detecting one or more biomarkers derived from a body fluid, comprising performing one or more assays for the biomarkers from a sample of the body fluid, whereby the sample is previously preserved on a solid support; wherein a change in the biomarkers provides an indication of a biological event in the brain. The invention also provides related methods for identifying a person as being at risk of dementia or alzheimer's disease, monitoring a person for the onset or progression of dementia or alzheimer's disease, evaluating the effectiveness of a potential pharmaceutical agent..
Ge Healthcare Uk Limited

Identification of a 5-gene expression signature predicting clinical outcome of patients with brain tumors

High-grade gliomas are the most common brain tumors in humans and are essentially incurable. The defining hallmark of these high-grade gliomas is the presence within the tumor mass of highly tumorigenic cellular subpopulations that fuel tumor aggressiveness.
The Trustees Of Columbia University In The City Of New York

Method for improving learning

The invention is directed to a method for improving learning and/or memory (e.g., auditory, visual, somatosensory or motor) in adults and children of an age which is beyond the early critical period for learning, said method comprising inhibiting (i) ecto-5′-nucleotidase (nt5e, aka cd73) or (ii) a1 adenosine receptor (a1r, aka adora1) expression or function in the brain. The invention is also directed to a method for treating learning and memory defects and neurological diseases associated with an abnormal auditory, visual, or somatosensory perception by inhibiting nt5e or a1r expression or function in the brain..
St. Jude Children's Research Hospital, Inc.

Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines

A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.. .
Boston Scientific Neuromodulation Corporation

Systems and methods for selective memory enhancement and/or disruption

Systems and methods are disclosed for selectively reinforcing or weakening memory associations. At least one current generator provides an electrical current including a plurality of oscillating pulses with at least one predetermined frequency.

Implantable intraventricular sampling and infusion access device

In some embodiments, a device may include an intraventricular access device and an infusion device. The intraventricular access device may include more than one catheter and a container.
Cerebral Therapeutics Llc

Peptides for assisting delivery across the blood brain barrier

The present invention provides compositions and methods useful for delivering agents to target cells or tissues, for example nerve cells and other cells in the central nervous system. The compositions and methods are useful for delivering agents across the blood-brain barrier.
Children's Medical Center Corporation

Rvg derived peptides

The invention relates to short rvg derived peptides for use in delivering therapeutic agents across the blood brain barrier and to target cells, for example those cells in the central nervous system. The invention provides method and compositions to treat diseases, such as neurodegenerative diseases, with therapeutic agents associated with targeting peptides..
United Arab Emirates University

Method for prolonging and enhancing anti-tumor vaccine response

A method for treating a tumor includes administering (i) a vaccine that contains stage-specific embryonic antigen 4 conjugated to a carrier, (ii) an antibody that binds specifically to ssea-4, and (iii) immune cells expressing a chimeric antigen receptor that specifically binds to ssea-4. The tumor, which expresses ssea-4, can be a breast, colon, gastrointestinal, kidney, lung, liver, ovarian, pancreatic, rectal, stomach, testicular, thymic, cervical, prostate, bladder, skin, nasopharyngeal, esophageal, oral, head and neck, bone, cartilage, muscle, lymph node, bone marrow, or brain tumor..

Methods of treating mild brain injury and post-traumatic stress disorder

The present disclosure provides methods for treating post-traumatic stress disorder (ptsd) and other neurological disorders in a subject, comprising administering to the subject an effective amount of a composition comprising ghrelin.. .
The Regents Of The University Of California

Method of inhibiting microglial cell migration and treating traumatic brain injury

Disclosed herein is a method of inhibiting microglial cell migration in the brain of a mammalian subject in need thereof, including subjects suffering from the symptoms of traumatic brain injury (tbi) and subjects suffering from a hematoma in the brain comprising administering an effective amount streptolysin o (slo) wherein microglial migration is inhibited providing therapeutic benefits to subjects suffering from diseases characterized by microglial cell migration and activation.. .
Beech Tree Labs, Inc.

Cns delivery of mrna and uses thereof

The present invention provides, among other things, methods and compositions for effective delivery of messenger rna (mrna) to the central nervous system (cns). In particular, the present invention provides methods and compositions for administering intrathecally to a subject in need of delivery a composition comprising an mrna encoding a protein, encapsulated within a liposome, such that the administering of the composition results in the intracellular delivery of mrna in neurons in the brain and/or spinal cord.
Translate Bio, Inc.

Brain-functional near infrared spectroscopy device and measurement method

Provided is a multi-channel brain-functional near infrared spectroscopy device capable of easily levelling detector noise. The following control is performed: setting transmittances of all of optical attenuators to 1, setting intensities of all of light sources to a maximum light intensity within a safe irradiation range; determining the effective illumination intensity of each light source probe i as well as a minimum effective illumination intensity and a maximum effective illumination intensity thereof; changing the transmittance ai of each optical attenuator i on the light source probe side to [the minimum effective illumination intensity/effective illumination intensity of each light source probe i], thereby levelling the effective illumination intensity; and increasing the intensities of all of the light sources by w=[the maximum effective illumination intensity/the minimum effective incident efficiency] times, and determining the effective detection rate of each detector probe j as well as the minimum effective detection rate thereof; and performing control so as to level the effective detection rate by changing the transmittance aj of each optical attenuator j on the detector probe side to [the minimum effective detection rate/effective detection rate of each detector probe j], thereby equalizing detector noise among all the channels k..
National Institute Of Advanced Industrial Science And Technology

Device to reduce traumatic brain injury

A device for reducing traumatic brain injury comprises a first sensor, a first linkage element, and a processing element. The first sensor is coupled to a head component and configured to measure an acceleration of a user's head and to generate a sequence of real-time measured samples.

Neurofeedback headgear for monitoring brain activity

A neurofeedback headgear is provided. The neurofeedback headgear comprises a head receiving portion, a brim portion, an eeg sensor assembly and an emitter.
Neuroservo Inc.

Interactive helmet system and method

An interactive helmet system and method for reducing brain injuries may provide a helmet and at least one inflatable air pouch. The at least one inflatable air pouch may remain in an active position and may pressurize or further inflate in response to an impact with a surface.
Joshua R&d Technologies, Llc

Systems and methods for monitoring of fractional gluconeogenesis and targeting of fractional gluconeogenesis via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Systems and methods for monitoring of blood lactate and targeting of blood lactate via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Method and system for analysing sound

The present invention relates to a method and system for analysing audio (eg. Music) tracks.
X-system Limited

Quantifying mass effect deformation with structural radiomics in brain tumor patients

Methods and apparatus quantify mass effect deformation in diagnostic images of patients demonstrating glioblastoma multiforme (gbm). One example apparatus includes an image acquisition circuit that acquires an image of a region of tissue demonstrating gbm pathology, a delineation circuit that segments a tumor region from the image, a pre-processing circuit that generates a pre-processed image by pre-processing the segmented image, a registration circuit that registers the pre-processed image with a template image of a healthy brain, a deformation quantification circuit that computes a set of differences between a position of a brain sub-structure represented in the registered image relative to the position of the brain sub-structure represented in the template image.
Case Western Reserve University

Automatic 3d brain tumor segmentation and classification

A fully automatic brain tumor segmentation and classification method and system improve the healthcare experience with machine intelligence. The automatic brain tumor segmentation and classification method and system utilize whole tumor segmentation and multi-class tumor segmentation to provide accurate analysis..
Sony Corporation

A novel person identification and personality assessment based on eeg signal

The present invention relates a novel system and method for person identification and personality assessment based on electroencephalography (eeg) signal. More particularly, this invention relates to a novel method of eeg recording and processing to map the inherent and unique properties of brain in the form of highly specific brain signature to be used as means for person identification and personality assessment..

Methods and compositions for diagnosing brain injury or neurodegeneration

Methods and compositions for diagnosing brain injury, neurodegeneration; or a predisposition thereto, in a subject are provided. Particularly, the present invention relates to specific antigen antibody reactivities useful in diagnosing brain injury, neurodegeneration or a predisposition thereto, in a subject..
Immunarray Usa, Inc.

Method for selection of agents influencing intestinal motility disorders and pain

A method is provided for evaluating agents for the treatment of different intestinal motility disorders, using distinct methodological parts related to musculature and nerves of the gi tract which communicate with the brain. In particular, the present invention provides a method for the selection of an agent effective for the treatment of an intestinal motility disorder, wherein said method comprises: a) a step of spatiotemporal (st) mapping carried out on a gastrointestinal segment to analyse the effect of said agent on gastrointestinal motility; and b) a step of ex vivo nerve bundle recording carried out on a gastrointestinal segment to analyse the effect of said agent on mesenteric afferent nerve firing.
Biogaia Ab

Modulators of the p70s6 kinase for use in the treatment of brain disorders and triple-negative breast cancer

And wherein, in each substituent consisting of or containing c1-4 hydrocarbyl, the c1-4 hydrocarbyl is selected from c1-4 alkyl, c2-4 alkenyl, c2-4 alkynyl, cyclopropyl, cyclobutyl and cyclopropylmethyl.. .

Compounds for stabilizing ryanodine receptors from aberrant levels of calcium release

Disclosed herein are methods and compositions comprising compounds capable of normalizing neuronal calcium dyshomeostasis. Also disclosed are methods comprising these compounds for treating neuronal or neurological disorders, including alzheimer's disease, parkinson's disease, huntington's disease, fronto-temporal dementia, pick's disease, chronic traumatic encepholopathy, traumatic brain injury, stroke, cerebellar ataxia, multiple sclerosis, down syndrome, and aging-related cns disorders..
Rosalind Franklin University Of Medicine And Science

Novel methods, compounds, and compositions for anesthesia

Methods of treatment useful in the inducement or maintenance of anesthesia in a subject are provided. The methods comprise administering to a subject in need of anesthesia a compound disclosed herein.
The United States Government As Represented By The Department Of Veterans Affairs

Method and improving cognitive performance

A method for delivering electrical stimulation to alter a cognitive state of a user, the method comprising: monitoring a brain signal from the user via one or more intracranial electrodes implanted in the brain of the user while the user is presented with a stimulus; comparing the brain signal to a testing phase biomarker, wherein the testing phase biomarker is derived from a cognitive test performed on a contributor during a testing phase; delivering electrical stimulation to a brain of the user based on the comparing step to steer the brain of the user towards a high performance cognitive state.. .
The Trustees Of The University Of Pennsylvania

Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes

The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering front a lysosomal storage disease a p97 conjugated with art enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.. .
Bioasis Technologies, Inc.

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Jenkem Technology Co., Ltd. (tianjin)

Low molecular weight polyethylene glycol drug conjugates having improved drug biological activity

Provided are polyethylene glycol drug conjugates of general formula (i), (ii) or (iii) and pharmaceutical compositions and a use thereof. The conjugates are formed by combining low molecular weight polyethylene glycol with 2-4 drug molecules.
Jenkem Technology Co., Ltd. (tianjin)

Compositions for enhancing brain activity

C) a synergistic combination of (a) and (b).. .

Production of midbrain dopaminergic neurons and methods for the use thereof

Methods are provided for efficient production of midbrain dopaminergic (da) neurons. In some aspects, methods involve differentiation and selection of da neurons for a transgenic pluripotent cell population (e.g., cells comprising a selectable marker gene).
Cellular Dynamics International, Inc.

Bolaamphiphilic compounds, compositions and uses thereof

Where hg1, hg2 and l1 are as defined herein. Provided bolaamphilphilic compounds and the pharmaceutical compositions thereof are useful for delivering biologically active drugs into animal or human brain..

Compounds and methods for treating neurological and cardiovascular conditions

The present invention relates to compounds and methods of use thereof for treatment of certain disorders and conditions, for example brain injuries such as stroke or traumatic brain injuries.. .
The Board Of Regents Of The University Of Texas Sy

Methods of treating apoptosis and altering programmed cell death

In one aspect, a method of altering programmed cell death includes administering to an individual in need thereof a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof. In other aspects, isomyosmine is administered to treat a wound, hemochromatosis, traumatic brain injury, or disorders associated with chronic oxidative stress.
Mymd Pharmaceuticals, Inc.

Mebendazole polymorph for treatement and prevention of tumors

Mebendazole is an antiparasitic drug with over 40 years of safe use. Recently mebendazole was repurposed for glioblastoma therapy.
The Johns Hopkins University

Tissue-orientation-based simulation of deep brain stimulation

The present invention relates to a medical data processing method for determining an orientation of nerve fibres relative to a non-physiological electric field, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring patient medical image data describing a patient medical image of an anatomical body part of a patient's body, the anatomical body part including nerve tissue comprising white matter nerve fibres; b) acquiring diffusion image data describing a diffusion-enhanced image of the anatomical body part; c) acquiring atlas data describing a spatial distribution of grey value-based tissue classes in a model body part representing a model of the anatomical body part; d) determining, based on the patient image data and the diffusion image data and the atlas data, fibre orientation data describing an orientation of the white matter nerve fibres; e) acquiring electric field orientation data describing an orientation of the non-physiological electric field which is an electric field simulated around a simulated electrode virtually placed in a predetermined spatial relationship relative to the anatomical body part; f) determining, based on the fibre orientation data and the electric field orientation data, relative orientation data describing a relative orientation between the orientation of the white matter nerve fibres and the orientation of the electric field.. .
Brainlab Ag

Methods and tools for diagnosing insulin resistance and assessing health status using nmr relaxation times for water

The subject invention pertains to a method that involves at least three steps: (1) acquisition of a nmr data set or spin relaxation curve for plasma, serum or whole blood samples, or for tissues monitored from outside the body, (2) analysis of the nmr data or relaxation curve to extract the t2 and/or t1 relaxation times for water (or surrogates thereof), and (3) conversion of the water t2 and/or t1 values (or surrogates thereof) into a measure of someone's health status (referred to as a t2 or t1 health score depending on the value (t1 or t2 or both t1 and t2) associated with the score). The t1 and/or t2 health score utilizes a statistical database derived from previous studies of subjects ranging from normal, healthy individuals to those having varying degrees of hidden or non-hidden metabolic abnormalities, such as inflammation, insulin resistance, lipid abnormalities (dyslipidemia), oxidative stress, brain abnormalities, cognitive impairment or other disorders, and provides a measure of a subject's overall metabolic and brain health status..
University Of North Texas Health Science Center At Fort Worth

Headgear with displaceable sensors for electrophysiology measurement and training

A method and system provides for headgear usable for electrophysiological data collection and analysis and neurostimulation/neuromodulation or brain computer interface for clinical, peak performance, or neurogaming and neuromodulation applications. The headgear utilizes dry sensor technology as well as connection points for adjustable placement of the bi-directional sensors for the recoding of electrophysiology from the user and delivery of current to the sensors intended to improve or alter electrophysiology parameters.
Evoke Neuroscience, Inc.

Auto-calibration of probabilistic tracking parameters for dti fibre tractography and compilation of tract probability comparison scales

1. A medical data processing method of determining information describing the probable position of a neural fibre in a patient's brain, the method comprising the following steps which are constituted to be executed by a computer: a) acquiring patient-specific medical image data describing the brain of the patient; b) acquiring atlas data defining an image-based model of a human brain; c) determining, based on the patient-specific medical image data and the atlas data, seed region data describing seed regions (a, b) in the patient-specific medical image data in which the ends of neural fibres of the patient's brain may be located; d) determining, based on the patient-specific medical image data and the seed region data, neural fibre tract data describing a plurality of potential tracts (t1, t2, t3) which a specific neural fibre may take through the patient's brain; e) determining, based on the atlas data and the neural fibre tract data, a figure of merit for each one of the potential tracts (t1, t2, t3)..
Brainlab Ag

Method and constructing a neuroscience-inspired artificial neural network with visualization of neural pathways

A method and apparatus for constructing one of a neuroscience-inspired artificial neural network and a neural network array comprises one of a neuroscience-inspired dynamic architecture, a dynamic artificial neural network array and a neural network array of electrodes associated with neural tissue such as a brain, the method and apparatus having a special purpose display processor. The special purpose display processor outputs a display over a period of selected reference time units to demonstrate a neural pathway from, for example, one or a plurality of input neurons through intermediate destination neurons to an output neuron in three-dimensional space.
University Of Tennessee Research Foundation

Bk channel-modulating peptides and their use

The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance ca2+ activated k+ (bk) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to the brain of a subject through the blood-brain barrier.. .
Board Of Regents, The University Of Texas System

Method, system and non-invasive neurostimulation therapy of the brain

The present invention is a portable non-invasive system, apparatus and method for performing light therapy or photobiomodulation upon the brain tissues through the skull and/or nostrils of a living mammalian subject for the medical purpose of stimulating the brain in-vivo. The present invention utilizes the transcranial and/or intranasal pathways as points of anatomic access and follows established principles for the conceptual approach that irradiation of the brain tissue with low level light energy of certain fixed parameters would achieve major therapeutic effects in-vivo..

Optogenetic control of endothelial cells

The invention features methods for regulating vascular properties by controlling the membrane properties of endothelial cells using optogenetics and light. The invention features methods to transport therapeutics across the vascular barrier into tissues such as the brain and the lung, with high spatial and temporal precision, and for controlling vascular properties such as vascular tone, arterial diameter, and vascular growth..
Massachusetts Institute Of Technology

Neurostimulation using ac and/or dc stimulation pulses

Neurostimulation is performed using electrical ac and/or dc stimulation pulses. brain and/or spinal cord stimulation of a patient is achieved using an implanted neurostimulation device.
Precisis Ag

Catheter and guide tube for intracerebral application

A catheter for use in neurosurgery, and a method of positioning neurosurgical apparatus. The catheter has a fine tube arranged for insertion into the brain parenchyma of a patient with an external diameter of not more than 1.0 mm.
Renishaw (ireland) Limited

Engineered receptor/ligand system for delivery of therapeutic agents

Provided herein are compositions and methods related to targeted delivery of a therapeutic or diagnostic agent to a subject utilizing an engineered receptor-ligand system, such as an engineered dockerin-cohesin system. As described herein, previously-developed targeted delivery systems for delivering therapeutic and diagnostic agents to a tissue of interest have drawbacks that have not been addressed to date.
University Of Florida Research Foundation, Inc.

Pharmaceutical composition for inhibiting growth of cancer stem cells, containing aldehyde inhibitor and biguanide-based compound

The present invention relates to a pharmaceutical composition for inhibiting growth of cancer stem cells, containing an aldehyde inhibitor and a biguanide-based compound. The pharmaceutical composition according to the present invention contains a combination of an aldehyde inhibitor and a biguanide-based compound, which can effectively inhibit the growth of cancer stem cells such as neurospheres and can also inhibit the proliferation, invasion and metastasis of cancer cells, thereby preventing and/or treating cancer such as brain cancer..
National Cancer Center

Robot for minimally invasive neurosurgery

A robotic device for performing intracranial procedures, comprising a baseplate for mounting on the subject's skull and a rotatable base element rotating on the baseplate. The rotatable base element has a central opening through which a cannulated needle can protrude such that it can rotate around an axis perpendicular to the baseplate.
Technion Research & Development Foundation Ltd.

Early diagnosis and treatment of alzheimer disease and mild cognitive impairment

Methods, systems and devices for detecting and treating cognitive impairment conditions by inducing stimulation to a predetermined region of the brain and measuring neural activity response to the stimulation and evaluating a neuroplasticity of neural-structures in a predetermined brain region, then stimulating the predetermined brain region to treat the cognitive impairment condition.. .
Nibs Neuroscience Technologies Ltd.

System and method to assess risk of changes to brain white matter based on head impact dose equivalent number

A system to assess risk of changes to brain white matter includes a sensor system adapted to measure an energy of each impact to an individual belonging to a sub-population that causes a repetitive head impact (rhi). A head impact dose equivalent number (hiden) process calculates a hiden for a most recent rhi event based on the energy of the most recent rhi event, a time of the most recent rhi, and all previously recorded rhi events available in a non-volatile memory.
University Of Rochester

Wearable physiological monitoring device

The present invention discloses a wearable physiological monitoring device for providing brain activity information and deciding a breathing guiding signal in a neurofeedback section, for being a basis for a user to perform a self-regulation about brain function. The device includes a wearable structure for mounting plural eeg electrodes and/or optical sensor on the head and/or an ear of the user so as to obtain information about brain activity and respiratory behavior..

Hearing assistance system comprising an eeg-recording and analysis system

A hearing assistance system comprises an input unit for providing electric input sound signals ui, each representing sound signals ui from a multitude nu of sound sources si, an electroencephalography (eeg) system for recording activity of the auditory system of the user's brain and providing a multitude ny of eeg signals yj, and a source selection processing unit receiving said electric input sound signals ui and said eeg signals yj, and in dependence thereof configured to provide a source selection signal Ŝx indicative of the sound source sx that the user currently pays attention to using a selective algorithm that determines a sparse model to select the most relevant eeg electrodes and time intervals based on minimizing a cost function measuring the correlation between the individual sound sources and the eeg signals, and to determine the source selection signal Ŝx based on the cost functions obtained for said multitude of sound sources.. .
Oticon A/s

Methods for improved measurements of brain volume and changes in brain volume

Methods of the disclosure may include obtaining a first set of medical images at a first time point and a second set of medical images at a second time point, each set including at least two medical images. First and second algorithms may be used to calculate, respectively, first and third brain volume (bv) values at the first time point based on two or more images from the first set of medical images and second and fourth bv values at the second time point based on two or more images from the second set of medical images.
Biogen Ma Inc.

Method and system for providing a brain computer interface

A method for providing a brain computer interface that includes detecting a neural signal of a user in response to a calibration session having a time-locked component and a spontaneous component; generating a user-specific calibration model based on the neural signal; prompting the user to undergo a verification session, the verification session having a time-locked component and a spontaneous component; detecting a neural signal contemporaneously with delivery of the verification session; generating an output of the user-specific calibration model from the neural signal; based upon a comparison operation between processed outputs, determining an authentication status of the user; and performing an authenticated action.. .
Arctop, Inc.

Methods and apparatuses for determining head movement

The present application discloses various methods and apparatuses for determining a head movement, wherein a method for determining a head movement disclosed comprises: acquiring, in response to a head movement of a human body, brain electricity detection information of a human body; and determining the head movement corresponding to the brain electricity detection information. The present application provides a new solution for head movement recognition, by which accuracy of head movement recognition is improved..
Beijing Zhigu Rui Tuo Tech Co., Ltd.

Use of an anti-alpha-synuclein antibody to diagnose an elevated level of alpha-synuclein in the brain

This disclosure relates to the use of anti-α-synuclein antibody to diagnose an elevated level of α-synuclein in the brain. Specifically, the disclosure relates to the method of assessing the levels of α-synuclein in a blood plasma or csf following administration to the test subject of an anti-α-synuclein antibody or antigen-binding fragment thereof, which can bind α-synuclein with sufficient activity to alter the net efflux of α-synuclein from brain to blood, or from brain to csf..
Biogen International Neuroscience Gmbh

Monoclonal antibody for the diagnosis, treatment and/or prevention of brain tumors and brain lesions

The invention relates to the use of the monoclonal antibody nilo1 for the diagnosis, treatment and/or prevention of brain tumors and lesions. Particularly, the invention relates to methods for the diagnosis of brain tumors and brain lesions in which cells marked with said antibody, or with immunologically active fragments thereof, are detected.
Consejo Superior De Investigaciones Cientificas (csic)





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