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 Modifying the modality of a computing device based upon a user's brain activity patent thumbnailModifying the modality of a computing device based upon a user's brain activity
Technologies are described herein for modifying the modality of a computing device based upon a user's brain activity. A machine learning classifier is trained using data that identifies a modality for operating a computing device and data identifying brain activity of a user of the computing device.

 Modifying a user interface based upon a user's brain activity and gaze patent thumbnailModifying a user interface based upon a user's brain activity and gaze
Technologies are described herein for modifying a user interface (“ui”) provided by a computing device based upon a user's brain activity and gaze. A machine learning classifier is trained using data that identifies the state of a ui provided by a computing device, data identifying brain activity of a user of the computing device, and data identifying the location of the user's gaze.

 Magnetic resonance imaging of neuro-electro-magnetic oscillations patent thumbnailMagnetic resonance imaging of neuro-electro-magnetic oscillations
In vivo methods of non-invasively imaging neuro-electro-magnetic oscillations (nemo) are carried out by electronically transmitting a pulse sequence to a subject. The pulse sequence has a first excitation pulse, typically applied along an x-axis, followed by a spin-lock pulse applied along a different axis, typically a y-axis, and having a defined frequency, followed by a second rf excitation pulse.
Duke University


 Method and system for providing electrical stimulation to a user patent thumbnailMethod and system for providing electrical stimulation to a user
A method for providing electrical stimulation to a user as a user performs a set of tasks during a time window, the method comprising: providing an electrical stimulation treatment, characterized by a stimulation parameter and a set of portions, to a brain region of the user in association with the time window; for each task of the set of tasks: receiving a signal stream characterizing a neurological state of the user; from the signal stream, identifying a neurological signature characterizing the neurological state associated with the task; and modulating the electrical stimulation treatment provided to the brain region of the user based upon the neurological signature, wherein modulating comprises delivering a portion of the set of portions of the electrical stimulation treatment to the brain region of the user, while maintaining an aggregate amount of the stimulation parameter of the treatment provided during the time window below a maximum limit.. .
Halo Neuro, Inc.


 Therapeutic multi-peptides t specific immune therapy for treatment of brain metastasis patent thumbnailTherapeutic multi-peptides t specific immune therapy for treatment of brain metastasis
The present invention relates to a peptide vaccine composition ose-2101 for treatment of brain metastasis in hla-a2 positive patients.. .
Ose Immunotherapeutics


 Compounds for use in the prevention or treatment of cancer patent thumbnailCompounds for use in the prevention or treatment of cancer
The invention relates to the field of prevention and treatment of cancer, in particular suppression of tumor manifestation. The invention also relates to compounds for use in this field.
Fujimoto Co. Ltd.


 System that measures different states of a subject patent thumbnailSystem that measures different states of a subject
An analysis system analyzes a state of a person and includes a terminal configured to be worn on the person's body. The terminal includes an acceleration sensor, a storage unit, and a processing unit.
Hitachi, Ltd.


 Device and  measuring blood oxygen level and/or detecting brain hematoma patent thumbnailDevice and measuring blood oxygen level and/or detecting brain hematoma
A device for measuring brain oxygen level of a subject, including a probe (210) and a detecting means (220), which are respectively coupled to a processor (230). According to the example, the probe (210) includes three light sources (215a, 215b, 215c) that simultaneously emit the first, second, and third nir wavelengths across the brain of the subject.
Mackay Memorial Hospital


 Method for locating tracts of electrical brain activity patent thumbnailMethod for locating tracts of electrical brain activity
A method and apparatus for locating tracts of electrical brain activity. A source localization procedure may be performed including solving the inverse problem subject to one or more constraints resulting from a tractographic procedure, and a tractographic procedure may be performed that includes obtaining a probabilistic assessment of tract connectivity that takes account of the results of a source localization procedure..
Electrical Geodesics, Inc.


 Customization of help information based on eeg data patent thumbnailCustomization of help information based on eeg data
A method (100) is implemented by a computing device for helping a particular user use a user interface (ui). Electroencephalography (eeg) data is obtained (102) that indicates brain activity of a particular user during a period in which that user views the ui and/or interprets help information that describes how to use the ui.

Digital command prompting device

The digital command prompting device is an aid is to help all people, especially those who have special needs particularly individuals who have diminished or diminishing function of their brain. The device is predominately mobile but can also be stationary and can be programmed by receiving and selecting pre-set commands to operate and assist a user with their daily living standards or needs.

Method of diagnosing and treating brain endothelial inflammation related disease

The presently claimed invention relates to materials and methods for diagnosing a chronic inflammatory disease in a patient comprising testing a biological sample from the patient for a level of a first neurovascular biomarker of lymphatic activation and diagnosing the patient as having the chronic inflammatory disease if the tested level of the first neurovascular biomarker of lymphatic activation is less than a first normal level.. .

Devices and methods of low frequency magnetic stimulation therapy

Described herein, in certain embodiments, are devices and methods for modulating the electrical activity of a brain in a targeted manner using a weak magnetic field, generally field with a strength of less than about 100 gauss. The magnetic field is varied over time in a periodic manner, generally with a frequency tuned to specifically affect one of the intrinsic frequencies of the brain, optionally the alpha frequency.

Transcranial control of procedural memory reconsolidation for skill acquisition

Described is a system for the therapeutic modification of human behavior and, more specifically, a system for the transcranial control of procedural memory reconsolidation for the purposes of enhanced skill acquisition. During operation the system records a practice pattern.

System and training and assessment

Described is a system for training and assessment. In operation, the system classifies a subject's baseline brain state and behavioral performance.

Sleep inducing device and sleep management system including same

A sleep inducing device and a sleep management system including the same are provided. The sleep inducing device comprises: a housing unit that includes a frame of which the shape can be changed; a sensor unit that is disposed on one surface of the housing unit and includes a brain-wave measurement sensor that measures a user's brain wave; an output unit that includes a first output unit and a second output unit, wherein the first output unit is located on one side of the housing unit to output a sound or light with a first frequency, and the second output unit is located on an opposite side of the housing unit to output a sound or light with a second frequency that is different from the first frequency; and a control unit that calculates the user's sleep pattern on the basis of the brain wave signal measured by the sensor unit and changes the output signal of the output unit such that the sleep pattern approaches a predetermined value..

Method for treating a brain tumour

A method of treating a brain tumour such as glioblastoma in a mammal is provided comprising administering to the mammal a drd4 antagonist.. .

Method for improving interstitial flow

Provided is a prophylactic and/or therapeutic drug for mild cognitive impairment, which can improve interstitial flow in cerebral blood vessel and the like to achieve sufficient clearance of harmful proteins accumulated in the brain. The prophylactic and/or therapeutic drug includes 6-[4-(1-cyclohexyl-1h-tetrazole-5-yl)butoxy]3,4-dihydrocarbostyril or a salt thereof as an active ingredient.

Methods of preventing and treating cerebral amyloid angiopathy (caa) with an edaravone medicament

The present invention belongs to pharmaceutical field, specifically, relates to use of edaravone in the preparation of a medicament for preventing and treating cerebral amyloid angiopathy (caa). By administering edaravone, the present invention could scavenge the deposited amyloid (aβ) in the brain and prevent the intracerebral aβ deposition..

Electromagnetic guiding tube for elongated medical implants

The present invention relates to a guiding tube for placing medical implants within body tissue, comprising an elongated, dimensionally stable tubular body encompassing an inner channel adapted to receive a medical implant, wherein the tubular body comprises at least one electromagnetic element, which is configured to exert an electromagnetic force on at least one magnetic element of the medical implant inserted into the inner channel. The present invention further relates to a corresponding medical implant for being placed within body tissue, particularly a stimulation lead, specifically a deep brain stimulation lead comprising at least one directional electrode, having an elongated body portion that is adapted to be inserted into an inner channel enclosed by a tubular body of a guiding tube, wherein at least one magnetic element provided on or in the body portion.

Methods for detecting and treating pain using brain activity

Disclosed are methods for detecting pain in a subject, such as a mammal (e.g., a human), using brain activity, e.g., as determined by electroencephalography. The methods are useful for treating or reducing the likelihood of pain in a subject by determining power amplitude from the power spectral density of the waveforms and, e.g., administering a therapeutic agent to the subject.

Sleep stage detection

Therapy delivery to a patient may be controlled based on a determined sleep stage of the patient. In examples, the sleep stage may be determined based on a frequency characteristic of a biosignal indicative of brain activity of the patient.

Method and processing electroencephalogram (eeg) signals

A method of processing eec signals received from a plurality electrodes. The method comprises processing the eec signals to determine a modulation index value for each electrode, determining one or more electrodes that have a modulation index value above a threshold level observed during ictal activity, and using the determined one or more electrodes, to identify one or more possible regions of interest corresponding to seizure zones of a subject's brain..

Electroencephalograph, brain wave measurement method, brain wave measurement system

The object is to acquire electroencephalogram of high resolution with fewer number of electrodes than usual. An electroencephalogram measurement apparatus comprising: a plurality of electrodes 110 attached on the scalp of a subject for acquisition of electroencephalogram signals of the subject; and an electroencephalogram generation unit 150 for generating an electroencephalograms at locations of the scalp where the electrodes are attached and electroencephalograms at locations of the scalp where the electrodes are not attached..

Non-contact body and head based monitoring of brain electrical activity

Apparatus and methods for monitoring electrical activity within the brain of a person (“brainwaves”) employing electrodes or other sensors placed proximate to portions of the body below the head to develop raw signals without physically touching the body and penetrating hair and clothing. Additionally, apparatus and methods for monitoring electrical activity within the brain of a person (“brainwaves”) employing non-contacting sensors placed proximate to portions of the head to develop raw signals.

Methods, computer-readable media, and systems for measuring brain activity

One aspect of the invention provides a method including: obtaining neural activity data for a first subject and a second subject during verbal interaction between the first subject and the second subject; and calculating coherence between the neural activity data for the first subject and the neural activity data for the second subject. Another aspect of the invention provides a non-transitory, tangible computer-readable medium comprising computer-readable program instructions for implementing the one or more of the methods described herein..

Systems, methods, and devices for detection and diagnosis of brain trauma, mental impairment, or physical disability

Systems, devices, and methods are disclosed which may be used to detect and determine the extent of brain trauma, mental impairment, physical disability, or other brain dysfunction by tracking one or more ocular responses.. .

Mems valve actuator system and method

A micro-electro-mechanical (mems) exhaust valve-based impact attenuating fluid filled cell for use in cushioning impact and decelerating of a wearer's body portion (e.g. Head, shoulder, torso, etc.) after an impact.

Systems and methods for enhancing a signal-to-noise ratio

Provided are methods and apparatus for enhancing a signal-to-noise ratio. In an example, provided is an apparatus configured to modify audio to better match the way the human brain processes audio by modifying the audio to a form which takes advantage of human echolocation capabilities.
Signal/noise Solutions L.l.c.

Planning, navigation and simulation systems and methods for minimally invasive therapy

Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery..
Synaptive Medical (barbados) Inc.

Evaluation apparatus and evaluation method

An evaluation apparatus comprises a brain wave acquiring unit that acquires a brain wave signal from each of a plurality of subjects; an intensity data generating unit that generates intensity data that represents an intensity of a signal component in a predetermined frequency band or a relation between intensities of signal components in a plurality of frequency bands; a correlation data generating unit that acquires pairs of two subjects for all combinations, calculates a cross-correlation coefficient for the intensity data at each point in time for the respective pairs, and generates, correlation data in the time-series form; and an output unit that generates evaluation data that numerically represents a degree of synchronization of brain wave fluctuation based on the correlation data.. .
Centan Inc.

Diagnostic method

A method of detecting the presence, or monitoring the severity of a condition characterised by the presence of fragments of a marker protein in the brain of a patient. The method comprises: (i) providing a sample comprising macrophages obtained from the patient; and (ii) detecting the presence of the marker protein or fragments thereof in the macrophages.
Inven2 As

Methods for treating neural cell swelling

A composition comprising a novel ca2+-activated, [atp]i-sensitive nonspecific cation (ncca-atp) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [ca]i.
The United States Of America As Represented By The Department Of Veterans Affairs

High throughput sequencing

The invention relates to a high throughput method for determining telomere length of mammalian chromosomal dna; primers for use in said method; a kit comprising said primers; use of said method to diagnose or prognose or to determine the risk of developing a telomere shortening disease such as cancer, ageing, neurological disorders including alzheimer's disease, parkinson's disease and other dementias, brain infarction, heart disease, chronic hiv infection, chronic hepatitis, skin diseases, chronic inflammatory bowel disease including ulcerative colitis, anaemia, atherosclerosis, barrett's oesophagus and cancers including pre-cancerous conditions, infertility, telomere syndromes including dyskeratosis congenita, aplastic anaemia, idiopathic pulmonary fibrosis, familial myelodysplastic syndrome-acute myeloid leukaemia, hoyeraal-hreiderasson syndrome, revesz syndrome, coats plus syndrome, bone marrow failure, and cryptogenic liver cirrhosis. Additionally, the invention also has application in assessing an individual's suitability to be a transplantation donor, for example a bone marrow donor..

B-lamella blocking peptide used for preventing and/or treating alzheimer's disease

Provided in the present invention are a β-sheet breaker peptide used for preventing and/or treating alzheimer's disease, and the use thereof for preventing and/or treating alzheimer's disease. The amino acid sequence of the β-sheet breaker peptide is his-lys-gln-leu-pro-phe-tyr-glu-glu-asp (seq id no:1).
Tianjin Medical University

Pro-neurogenic compounds

Compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death are disclosed herein. In vivo activity tests suggest that these compounds may have therapeutic benefits in neuropsychiatric and/or neurodegenerative diseases such as schizophrenia, major depression, bipolar disorder, normal aging, epilepsy, traumatic brain injury, post-traumatic stress disorder, parkinson's disease, alzheimer's disease, down syndrome, spinocerebellar ataxia, amyotrophic lateral sclerosis, huntington's disease, stroke, radiation therapy, chronic stress, abuse of a neuro-active drug, retinal degeneration, spinal cord injury, peripheral nerve injury, physiological weight loss associated with various conditions, as well as cognitive decline associated with normal aging, chemotherapy, and the like..
Board Of Regents Of The University Of Texas System

Composition and treating metabolic disorders

Bromocriptine citrate administered to a vertebrate, animal or human, can be used for any purpose including, e.g., the long-term modification and regulation of metabolic disorders, including prediabetes, obesity, insulin resistance, hyperinsulinemia, hyperglycemia and type 2 diabetes mellitus (t2dm) and/or, e.g., the treatment of other medical disorder(s) including immune or endocrine disorders or diseases. Bromocriptine citrate is administered over a limited or extended period at a time of day dependent on re-establishing the normal circadian rhythm of central dopaminergic activity of healthy members of a similar species and sex.
Veroscience Llc

Heteroaryl compounds comprising nitrogen and use thereof

The compounds according to the present invention exhibit a remarkable effect on inhibiting proliferation of cancer cells and metastasis and recurrence of cancer with a reduced dose compared to that of existing drugs. Accordingly, the compounds can be effectively used for treating various types of cancer, such as uterine cancer, breast cancer, gastric cancer, brain cancer, rectal cancer, colorectal cancer, lung cancer, skin cancer, blood cancer, pancreatic cancer, renal cancer, prostate cancer, bladder cancer, and liver cancer, and for inhibiting proliferation of cancer cells and metastasis of cancer..

Brain stimulation response profiling

Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses.
Medtronic, Inc.

Adaptive cognitive prosthetic and applications thereof

An adaptive cognitive prosthetic that learns to replace neural function that was lost due to a brain injury or disease is described herein. In some embodiments, an adaptive cognitive prosthetic comprises a processing unit for converting input data from an input assembly into a cognitive variable and selecting a stimulation pattern for conveying the cognitive variable.
The Trustees Of Princeton University

Systems and methods for network based neurostimulation of cognitive processes

This invention relates generally to systems and methods for multifocal direct brain stimulation to enhance cognitive processing, such as but not limited to stimulation-induced modulation of memory.. .
The Board Of Regents Of The University Of Texas System

Adjunctive therapy delivery using a dbs lead

Various aspects of the present disclosure are directed toward apparatuses, systems and methods for treating an ischemic brain injury. Certain aspects include delivering the treatment substrate to a therapy region in a patient's brain.
Boston Scientific Neuromodulation Corporation

Systems and methods for preventing, mitigating, and/or treating dementia

The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-β (aβ) peptide, c-terminal fragment-β (β-ctf), β-secretase (bace1), γ-secretase, neuroinflammation, and/or dementia (e.g., alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (fs-pv) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.. .

Systems for brain stimulation during sleep and methods of use thereof

The present invention relates to systems for brain stimulation during sleep and methods for increasing vividness of a subject's dreams or for directing the subject matter of a subject's dreams. The system comprises a brain stimulation module and at least one of a brain energy source and/or a hypnotic source.
Able Cerebral, Llc

Angiopep and derivatives thereof for imaging amyloids

The present application relates to the molecular labeling and in vivo imaging of amyloids. Specifically, the present application relates to a polypeptide-based method/vector for targeting amyloids.
University Of Science And Technology Of China

Regenerating functional neurons for treatment of disease and injury in the nervous system

Methods for producing new neurons in the brain in vivo are provided according to aspects of the present invention which include introducing neurod1 into a glial cell, particularly into a reactive astrocyte or ng2 cell, thereby “converting” the reactive glial cell to a neuron. Methods of producing a neuronal phenotype in a glial cell are provided according to aspects of the present invention which include expressing exogenous neurod1 in the glial cell, wherein expressing exogenous neurod1 includes delivering an expression vector, such as a viral expression vector, including a nucleic acid encoding the exogenous neurod1 to the glial cell..
The Penn State Research Foundation

Ang-(1-7) derivative oligopeptides for the treatment of pain and other indications

The present invention provides oligopeptides, in particular, ang-(1-7) derivatives, and methods for using and producing the same. In one particular embodiment, oligopeptides of the invention have higher blood-brain barrier penetration and/or in vivo half-life compared to the native ang-(1-7), thereby allowing oligopeptides of the invention to be used in a wide variety of clinical applications including in treatment of cognitive dysfunction and/or impairment, pain, and traumatic brain injury..
Arizona Board Of Regents On Behalf Of The University Of Arizona

Sglt-2 inhibitors for treating metabolic disorders in patients with renal impairment or chronic kidney disease

The present invention relates to certain sglt-2 inhibitors, such as ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof, for treating and/or preventing metabolic disorders, such as type 1 or type 2 diabetes mellitus or pre-diabetes, in patients with renal impairment or chronic kidney disease (ckd). The present invention also relates to methods for preventing neuronal damage following the incidence of ischemic stroke and close-head traumatic brain injury in animals comprising the step of administering to an animal, in need of such treatment, a therapeutically effective amount of ertugliflozin or a co-crystal or a pharmaceutically acceptable salt thereof..
Pfizer Inc.

Uses of chlorogenic acid in the preparation of medicaments for treatment of mesoglioma

The present invention provides uses of chlorogenic acid in the preparation of medicaments for treatment of mesoglioma. Chlorogenic acid according to the present invention has an inhibitory action against mesoglioma, and can inhibit the growth of brain tumor stem cells, thus can partly substitute chemoradiation.
Sichuan Jiuzhang Biological Science And Technology Co., Ltd

Baclofen formulations and methods for making same

Methods for preparing sterilized baclofen solutions include adjusting the ph to below a desired ph, and steam sterilizing the solution with adjusted ph, which results in the solution having the desired ph. Such solutions may also have low concentrations of 4-cpp.
Saol International Limited

Reducing brain injury by limiting brain motion during sudden deceleration or acceleration of the head

A brain injury reduction system provides a protective measure that temporarily or decreases venous drainage out of the intracranial compartment during or immediately before and during a sudden change in acceleration of an individual's head. Specifically, a wearable helmet or other wearable structure of the brain injury reduction system detects an impending collision and determines whether a protective measure is needed.
Slomo Technologies, Llc

Methods and systems for controlling body parts and devices using ipsilateral motor cortex and motor related cortex

A system for controlling a body part includes a number of sensing devices that sense signals from a hemisphere of a brain. A signal translating unit translates the signals into a command signal for controlling the body part, which is on a same side of the body as the hemisphere of the brain.
Washington University

Onboard system, vehicle control device, and program product for vehicle control device

An onboard system equipped to a vehicle includes a vehicle control device controlling a switching of a driving mode of the vehicle between a manual driving and a self-driving, and a brain activity sensor capable of detecting an activated portion of a brain of a driver of the vehicle. The vehicle control device determines whether a degree of uneasiness felt by the driver exceeds a threshold or not based on a detection result detected by the brain activity sensor before the switching of the driving mode.
Denso Corporation

Protective cap

A protective cap for protecting a brain within a head from concussions and brain injuries commonly associated with sports or assault is provided. The protective cap comprises a cap having an outer surface and an inner surface.

Arbitration processing method after cluster brain split, quorum storage apparatus, and system

The present disclosure discloses an arbitration processing solution when brain split occurs in cluster. The solution includes: receiving, by the quorum storage apparatus, first master quorum node preemption requests within a first master quorum node preemption detection period sent by the at least two quorum nodes when brain split occurs in the cluster; sending, by the quorum storage apparatus, a first master quorum node preemption success response message to the initial master quorum node when the first master quorum node preemption request sent by the initial master quorum node is received; where the first master quorum node preemption success response message indicates the initial master quorum node succeeds in master quorum node preemption..

Methods and systems for assessing psychological characteristics

A method for assessing a pre-cognitive emotional response from a test subject, using responses obtained during the first moments of brain activity after presentation of a stimulus, includes exposing the test subject to a visual stimulus for between approximately 500 milliseconds and approximately 1 second, and receiving an input from the subject while the subject is exposed to the visual stimulus or within approximately 300 milliseconds after the subject is first exposed to the stimulus. The method further includes storing, in response to receiving the input, a user response that identifies one of a plurality of emotional reactions that is associated with the visual stimulus.

Vitelline membrane as a model of the blood brain barrier

The vitelline membrane of an egg is a novel, inexpensive and useful model of the human blood brain barrier (bbb). Fd&c blue #1, fd&c red #40, fd&c red #3, quinine and fluorescein do not cross the vitelline membrane and do not cross the human bbb.

Novel compounds as rearranged during transfection (ret) inhibitors

This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .

Multivalent compounds for use in the treatment and prevention of brain damage

Wherein r1-r11, l, z, y, and z are as defined in the claims. The invention also relates to said compounds for use as a medicament and particularly in the treatment of traumatic brain injury..

Bioelectrical modulation using rotating or spatially-selective electromagnetic fields

Described here are bioelectric modulation systems and methods for generating rotating or spatially-selective electromagnetic fields. A modulation system includes a multichannel electrode with independently controllable electrode channels that can be operated to generate rotating electromagnetic fields that stimulate cells regardless of their orientation, or to generate spatially-selective electromagnetic fields that preferentially stimulate cells oriented along a particular direction.

Electrical substance clearance from the brain for treatment of alzheimer's disease

Apparatus is provided that includes a parenchymal electrode, configured to be implanted in brain parenchyma of a subject identified as at risk of or suffering from alzheimer's disease; and a ventricular electrode, configured to be implanted in a ventricular system of a brain of the subject. Control circuitry is configured to drive the parenchymal and the ventricular electrodes to clear a substance from the brain parenchyma into the ventricular system.

System and automated quantitative assessment, optimization and logging of the effects of a therapy

A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject's brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method..

Implantable device for the brain

The present invention consists of an implantable device with at least one package that houses electronics that receives input data or signals, and optionally, power, from an external system through at least one coil attached to the at least one package, processes the input data and delivers electrical pulses to neural tissue through at least one array of multiple electrodes that is/are attached to the at least one package. The invention, or components thereof, is/are intended to be installed in the head, or on or in the cranium, or on the dura, or on or in the brain..

Anti-tau antibody and uses thereof

The present invention relates to tau-specific antibodies, fragments thereof, and uses thereof. More specifically, the present invention relates to tau-specific antibodies, fragments thereof, and conjugates thereof with conjugated to a superparamagnetic nanoparticle.

Brain permeant peptidomimetic beta-secretase 1 inhibitors for the treatment or prophylaxis of neurological disorders or conditions

The present application presents novel peptidomimetic substituted hydroxyethylene compounds, which are inhibitors of beta amyloid cleavage enzyme, capable to permeate the brain and to achieve therapeutic concentrations in the target organ, the brain. These compounds are incorporated in pharmaceutical compositions and applied in the treatment or prophylaxis of neurological disorders or conditions and also other disorders or conditions including down's syndrome and diabetes..

Pharmaceutical composition for treating cerebral atrophy associated disease

The present invention provides a pharmaceutical composition to treat cerebral atrophy associated disease. Said pharmaceutical composition comprising adipose-derived stem cells, can reverse the function of excitatory synapses in dementia patients and improve the function of memory storage area in brain..

Pharmaceutical compositions comprising levodopa amide and uses thereof

The present invention discloses various aqueous pharmaceutical compositions comprising a levodopa amide compound, or a salt thereof, which are stable for at least 24 hours at room temperature, and use thereof in treatment of diseases or disorders characterized by neurodegeneration and/or reduced levels of brain dopamine, e.g., parkinson's disease.. .

System and method to facilitate analysis of brain injuries and disorders

In an example embodiment, this disclosure provides a computer system that includes a processor configured to compute, based on test performance data of a user, at least one performance variable characterizing balance and postural stability, and at least one performance variable characterizing vestibulo-ocular reflex (vor). For each performance variable, processor can compute a respective score based on the respective performance variable and based on a set of performance metrics.

Method and system for managing pain

A method of managing pain using neurophysiological data acquired from the brain of a subject is disclosed. The method comprises: identifying activity-related features in the data; parceling the data according to the activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain; comparing at least some of the defined capsules to at least one reference capsule; and assessing the likelihood that the subject is experiencing pain responsively to the comparison..

Arbitration processing method after cluster brain split, quorum storage apparatus, and system

The present disclosure discloses an arbitration processing solution when brain split occurs in cluster. The solution includes: receiving, by a quorum storage apparatus within a first refresh packet detection period, first master quorum node preemption requests sent by at least two quorum nodes in the cluster; sending, by the quorum storage apparatus, a first master quorum node preemption success response message to the initial master quorum node indicating that the initial master quorum node succeeds in master quorum node preemption when the first master quorum node preemption requests received within the first refresh packet detection period comprise the master quorum node preemption request sent by the initial master quorum node..
Huawei Technologies Co.,ltd.

Electronically analyzing user activity on a graphical user interface

Systems and methods that help ensure that content on a webpage is read and understood by analyzing user activity on a graphical user interface are described. As a user views and interacts with a webpage, activity of the user is monitored.
Paypal, Inc.

Methods of detecting breast cancer brain metastasis with genomic and epigenomic biomarkers

The present invention provides a method of diagnosing a breast cancer central nervous system (cns) metastasis in a subject, comprising determining the expression level of at least one biomarker in a subject-derived brain or breast tissue comparing the subject-derived expression level with a normal control level obtained from normal brain or breast cells; and correlating an increase or decrease of the subject-derived expression level as compared to the normal control level to a diagnosis of a breast cancer cns metastasis. The present invention also provides a method for the treatment of a breast cancer cns metastasis in a subject comprising administering to the subject an inhibitor of an overexpressed gene associated with cns metastasis..
The Translational Genomics Research Institute

Method for selectively inhibiting acat1 in the treatment of neurodegenerative diseases

The present invention features methods for stimulating clearance of misfolded or aggregated proteins or peptides in microglia or neurons, and treating neurodegenerative diseases associated with such pathology in brain by selectively inhibiting the expression or activity of acyl-coa: cholesterol acyltransferase 1, but not acyl-coa: cholesterol acyltransferase 2.. .
Trustees Of Dartmouth College

Ultrasound deep brain stimulation method and system

An ultrasound deep brain stimulation method and system, the ultrasound deep brain stimulation method comprises: medically imaging a head of an animal or a human being, to generate image data; creating a head 3d digital model according to the image data; creating a 3d digital model of an ultrasound transducer array according to structure, density and acoustic parameters information of the ultrasound transducer array; generating a first ultrasound transmitting sequence according to the head 3d digital model, the 3d digital model of the ultrasound transducer array, structure, density and acoustic parameters of the skull and brain tissues, and structure, density and acoustic parameters of the ultrasound transducer array; and controlling the ultrasound transducer array to transmit ultrasound waves in accordance with the first ultrasound transmitting sequence, to implement ultrasound deep brain stimulation to the brain nucleus to be stimulated. By the use of the present invention, ultrasound can noninvasively passes through the skull to be focused in a deep brain region.
Shenzhen Institutes Of Advanced Technology Chinese Academy Of Sciences

Use of transcranial magnetic stimulation to modulate permeability of the blood-brain barrier

Transcranial magnetic stimulation (tms) is used to modulate permeability of the blood brain barrier in a transient, safe and non-invasive manner. A conventional or deep tms coil may be placed on a head in a vicinity of a tumor, for example.
Brainsway, Ltd.

System and brain stimulation for improvement of motor symptoms in parkinson's disease and other movement disorders

An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms in parkinson's disease (pd) and other movement disorders.
The Johns Hopkins University

Materials and methods for the delivery of a nanocarrier to the brain

Materials and methods for magnetically guided delivery of nanoparticles across the blood brain barrier (bbb) in the central nervous system (cns) are provided. The method can comprise injecting a subject with an aqueous solution comprising magneto-electro nanoparticles and applying a static magnetic field directed toward the subject brain, thereby inducing a stimulus response of the nanoparticles in a controlled manner.
The Florida International University Board Of Trustees

Estrogen therapy for brain gray matter atrophy and associated disability

Provided are methods for slowing, halting, and reversing gray matter atrophy and progression of disability in certain neurodegenerative diseases, including multiple sclerosis, using estrogen, alone or in combination with another agent.. .
The Regents Of The University Of California

Stable micelle and/or liposome compositions and uses thereof

Pharmaceutical compositions comprising stabilized self-assembling amphiphilic molecular structure (sams) having average diameters of 120 nm or less with a low zeta potential of less than 30 mv to be used for total parenteral nutrition (tpn) or total parenteral alimentation (tpa), increase blood pressure, renal dialysis, transport and release hydrophobic gases, exchange transfusion to replace blood, extracorporeal membrane oxygenation (ecmo), open constricted or blocked blood vessels, treat septic shock and irreversible shock due to sepsis and/or severe blood loss irreversible septic shock, treat dilutional coagulopathy of severe blood loss and bleeding with loss of clotting factors, and replace lost volume in childhood diseases that cause hypovolemia or severe hypovolemia, treat traumatic brain injury, burns, diagnosis of diseases and methods of making and using said compositions.. .
Vivacelle Bio, Inc.

Method for storing data of photoelectrically synchronous brain activity recording

A method for storing data of photoelectrically synchronous brain activity recording, said method comprising: generating data when a photoelectrically synchronous brain activity detection system is operating; generating from said data a data storage file comprising a basic information data segment, a near-infrared spectrum data segment and a brain electrical activity data segment, and sequentially storing said data segments into a .neg file in binary form according to the above order. The method can store comprehensive test information, flexibly configure the near-infrared and brain electrical measurement information, and realize synchronous storage of near-infrared data and brain electrical data and maintain file version compatibility..
Institute Of Automation Chinese Academy Of Sciences

Arrangements for supporting an animal under investigation while monitoring one or more brain processes

Mobile platforms and air table arrangements for supporting an animal under investigation include a mobile platform and an underlying air table platform that defines a perforated upper surface and a plurality of apertures in fluid communication with a source of air under pressure. The mobile platform is adapted to glide over the perforated upper surface and includes a base defining an upwardly facing surface and a downwardly facing surface, at least one sidewall circumscribing the upwardly facing surface, and at least one partition wall dimensioned and arranged to divide the downwardly facing surface into a plurality of downwardly facing open compartments.

Method for simulating brain stimulation, corresponding device and computer program

A method is provided for simulating a brain stimulation, delivering an estimation of a target spatial zone of stimulation. The method includes at least one iteration of the following acts: selection, from among at least two available values, of a value, referred to as a selected value, to be assigned to a pre-determined score; and identification, within an anatomo-clinical atlas belonging to a set of anatomo-clinical atlases, of a spatial zone capable of delivering a value close to said selected value to be assigned to said pre-determined score.
Institut National De Sante Et De Recherche Medical

Methods of diagnosing proliferative disorders

The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. Gliomas).
University Of Central Lancashire

Sprr1a as a genetic target for treating neurodegenerative diseases

This invention relates to the prevention and treatment of neurodegenerative diseases by administering compositions that increase the activity of a small proline-rich repeat 1 a protein (sprr1a), or derivative thereof to the brain. Specifically, the compositions may comprise a nucleic acid molecule encoding a sprr1a protein or a biologically-active portion thereof.
Board Of Trustees Of Michigan State University

Methods for efficient derivation of human motor neurons from diverse spinal regions

Described herein are chemically defined, adherent culture protocols for generating functional motor neurons characteristic of diverse hindbrain and spinal cord regions, with high efficiency.. .
Wisconsin Alumni Research Foundation

Methods for differentiation of human pluripotent stem cells to brain microvascular endothelial cells

Methods for generating functional brain microvascular endothelial cells (bmecs) under chemically defined, serum-free conditions are provided. In particular, efficient and cost-effective methods for generating functional bmecs under chemically defined culture conditions are provided.
Wisconsin Alumni Research Foundation

Methods for enhancing permeability to blood-brain barrier, and uses thereof

Disclosed herein is a method of facilitating the delivery of an agent across blood-brain barrier (bbb) of a subject. The method includes administering to the subject in sequence or concomitantly, an effective amount of a growth factor selected from the group consisting of, vascular endothelial growth factor (vegf), insulin-like growth factor i (igf-1), igf-ii, a portion thereof and a combination thereof; and an agent that is any of a therapeutic agent or an imaging agent.
Academia Sinica

Nanobodies suitable for neuron regeneration therapy

The invention is in the domain of delivery of molecules to brain cells across the blood-brain barrier. The invention relates to a novel polypeptide-based carrier that allows the efficient delivery of an effector peptide, to neuron cells across the blood-brain barrier, and to methods for the production and testing of such carrier, including a model for testing the capacity of such molecule to cross the blood-brain barrier and/or the toxicity of molecules on the blood brain barrier and/or the capacity of molecules that have crossed to target human brain cells (e/g.
Institut Pasteur

Antibodies, pharmaceutical compositions and methods

Pharmaceutical composition comprising antibodies or antigen binding fragments thereof that bind to stage-specific embryonic antigen 4 (ssea-4) are disclosed herein, as well as methods of use thereof. Methods of use include, without limitation, cancer therapies and diagnostics.
Obi Pharma, Inc.

Compounds and methods for kinase modulation, and indications therefor

In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of fms, kit, flt3, trka, trkb and trkc kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of fms, kit, flt3, trka, trkb and trkc, including rheumatoid arthritis, osteoarthritis, osteoporosis, peri-prosthetic osteolysis, systemic sclerosis, demyelinating disorders, multiple sclerosis, charcot marie tooth syndrome, amyotrophic lateral sclerosis, alzheimer's disease, parkinson's disease, global ischemia, ulcerative colitis, crohn's disease, immune thrombocytopenic purpura, atherosclerosis, systemic lupus erythematosis, myelopreparation for autologous transplantation, transplant rejection, glomerulonephritis, interstitial nephritis, lupus nephritis, tubular necrosis, diabetic nephropathy, renal hypertrophy, type i diabetes, acute pain, inflammatory pain, neuropathic pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, prostate cancer, pancreatic cancer, lung cancer, ovarian cancer, gliomas, glioblastoma, neurofibromatosis, osteolytic bone metastases, brain metastases, gastrointestinal stromal tumors, and giant cell tumors..

Method and system for determining settings for deep brain stimulation

A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding v-field. The brain stimulation probe comprises multiple stimulation electrodes.
Neuronexus Technologies, Inc.

Systems and methods for patient rehabilitation using brain stimulation

Systems and methods are provided for stimulating the brain of a patient to treat a medical condition. In some aspects, a method includes positioning a stimulating device comprising electrical contacts configured to electrically stimulate locations associated with a patient's brain, and initiating a rehabilitation process to include the patient performing a task.
The General Hospital Corporation

Optical stimulation implant

An implantable medical device for providing phototherapy to a patient's brain is disclosed. The device includes a housing containing a light source for providing phototherapy to a patient.
Boston Scientific Neuromodulation Corporation

Skull-mounted optical implant

A skull-mountable medical device is disclosed. The device includes a housing containing a light source for providing phototherapy to a patient.
Boston Scientific Neuromodulation Corporation

Personalized auditory-somatosensory stimulation to treat tinnitus

Timed stimulation of both somatosensory system and auditory system is controlled, in such a manner, that an individual's brain activity is altered through spike-timing dependent plasticity, thereby reducing or removing tinnitus.. .
The Regents Of The University Of Michigan

Lactoferrin-conjugated nanoparticle complex and use thereof

The present invention relates to a lactoferrin-conjugated nanoparticle complex and a novel use thereof. In the nanoparticle complex according to the present invention, lactoferrin or polyethylene glycol-lactoferrin is bound to metal nanoparticles, and according to this construction, it can be confirmed that the metal nanoparticles are not only efficiently targeted to the brain tumor tissues, but also the stability of the metal nanoparticles can be maintained even in the in vivo conditions, and thus it is expected in the treatment of brain tumors to be treatable to targets by approaching more fundamentally..
Industry-university Cooperation Foundation Hanyang University

Conjugates including an antibody moiety, a polypeptide that traverses the blood-brain barrier, and a cytotoxin

The present invention relates to antibody-polypeptide-cytotoxin conjugates and methods of making, packaging, and using the conjugates. The polypeptide can be a kunitz-type protease inhibitor or a derivative thereof that facilitates transport of the conjugate across the blood-brain barrier and/or into cancer cells outside the cns, and the antibody moiety selectively binds a target within the cns or in peripheral tumors to direct the cytotoxic agent to that target (e.g., a tumor or cancer cell).
Angiochem Inc.

A neural substrate for sugar preference

This invention concerns a composition and a method of modulating the craving and/or desire for natural sugar in a subject comprising: agonizing or stimulating or antagonizing or silencing a selective group of neurons in the cadual nucleus of the solitary tract (cnst) of the brain in the subject, whether directly or via the gut or gut-brain axis.. .
The Trustees Of Columbia University In The City Of New York

Methods of treating mild brain injury

The present disclosure provides methods for treating mild brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a compound comprising a ghrelin or ghrelin variant. This invention provides for methods for treating a mild brain injury or concussion in a patient wherein said method comprises administering to the subject in need thereof suffering from said mild brain injury or concussion an effective amount of a ghrelin variant or a composition comprising a ghrelin variant so as to treat said mild brain injury or concussion..
Oxeia Biopharmaceuticals, Inc.

Use of nitrite salts for the treatment of cardiovascular conditions

It has been surprisingly discovered that administration of nitrite to subjects causes a reduction in blood pressure and an increase in blood flow to tissues. The effect is particularly beneficial, for example, to tissues in regions of low oxygen tension.
Wake Forest University

Use of 4-aminopyridine to improve neuro-cognitive and/or neuro-psychiatric impairment in patients with demyelinating and other nervous system conditions

Disclosed herein are methods and compositions related to use of aminopyridines, such as 4-aminopyridine, to improve the neuro-cognitive impairments and related neuro-psychiatric impairments of patients with a demyelinating condition such as ms, traumatic brain injury, cerebral palsy, post-radiation encephalopathy.. .
Acorda Therapeutics, Inc.

Methods for treating brain injury

The treatment options for treating blast-induced and noise-induced traumatic brain injury and tinnitus are limited. Thus, the current invention provides methods for treating traumatic brain injury and tinnitus.
Oklahoma Medical Research Foundation

Sensor-based condition monitor

A sensor-based system that measures at least one parameter relating to an individual and provides feedback to the individual when any of the measured parameters exceed a threshold value for that parameter. In some instances, the system can be used to monitor an individual recovering from a condition, for example, mild traumatic brain injury.
Cognitive Health Llc

Methods and magnetic imaging devices to inventory human brain cortical function

Techniques are described for determining cognitive impairment, an example of which includes accessing a set of epochs of magnetoencephalography (meg) data of responses of a brain of a test patient to a plurality of auditory stimulus events; processing the set of epochs to identify parameter values one or more of which is based on information from the individual epochs without averaging or otherwise collapsing the epoch data. The parameter values are input into a model that is trained based on the parameters to determine whether the test patient is cognitively impaired..
Brain F.i.t. Imaging, Llc

Brain activity estimation device

A brain activity estimation device includes a facial skin temperature acquisition element and a brain activity estimation element. The acquisition element detects a skin temperature of at least part of a human face, and acquires facial skin temperature data including detected temperature data and location data of a detection region in a time series manner.
Tokyo Institute Of Technology

Non-invasive blood flow measurement

A system for determining blood flow to and from the brain of a patient includes a plurality of magnetic elements configured to be positioned adjacent to the neck of the patient and apply at least one magnetic field to the neck of the patient. The system includes a plurality of electrodes configured to be in electrical contact with the neck of the patient, the electrodes configured to detect a voltage induced across the neck of the patient responsive to the applied magnetic field and blood flow through the neck of the patient.
Zoll Medical Corporation

Protective headwear to reduce risk of injury

A helmet configured to protect a human head against mild traumatic brain injury upon impact includes an outer shell and a liner consisting of fluid fillable flexible fluid chambers fluidly connected to each other by fluid connections. The fluid chambers being spaced around the circumference of the helmet and configured to fill a space between the head and the outer shell when the helmet is positioned on the head.

Mechanical-waves dispersing protective headgear apparatus

The present invention provides an apparatus to disperse and attenuate mechanical waves which travel through a human brain upon direct and indirect blunt head trauma. The apparatus comprises a pressurizable and ventable outer balloon shell encasing an inner hard shell.

Wearable device and application system

The present invention provides a wearable device and an application system. The wearable device is configured to be worn by a wearer and includes: a brain wave collection unit configured to collect a brain wave of the wearer; a determination unit configured to obtain an instruction according to the brain wave collected by the brain wave collection unit and send the instruction to a sending unit; and the sending unit configured to send control information to an application device according to the instruction sent from the determination unit.
Boe Technology Group Co., Ltd.

Methods and compositions for personalized medicine by point-of-care devices for brain natriuretic peptide

Methods, devices, reagent, systems and kits for the detection, diagnosis of ovarian cancer as well as for the monitoring of ovarian cancer progression and for monitoring the progress of ovarian cancer treatments using bnp as a biomarker.. .
Autotelic Llc

Method of analysis allowing avoidance of surgery

A multi-gene-based assay for analysis of the following: (a) oncogene expression; (b) dna methylation of tumor suppressor genes; (c) non-coding rna expression (microrna profiling); and (d) long non-coding rna expression in cancer samples is disclosed. The assay method and device for conducting the assay are applicable to diagnosis, prognosis, and treatment of various cancers such as lung, breast, colorectal, prostate, liver, bladder; kidney, cervix, pancreatic, gastric, brain, oral, endometrium, and ovary.
Miodx

Regulation of autonomic control of bladder voiding after a complete spinal cord injury

In various embodiments methods and devices are provided for regulating bladder function in a subject after a spinal cord and/or brain injury. In certain embodiments the methods comprise applying a pattern of electrical stimulation to the lumbosacral spinal cord at a frequency and intensity sufficient to initiate micturition and/or to improve the amount of bladder emptying.
The Regents Of The University Of California

Electroosmotic tissue treatment

A method is provided that includes implanting a first electrode at a first site in a brain of a subject suffering from hydrocephalus, and a second electrode at a second site in the subject. The hydrocephalus is treated by electroosmotically driving fluid out of the first site, by applying a treatment voltage between the first and the second electrodes..
Rainbow Medical Ltd.

System and administering, monitoring and controlling biomimetic sleep

Systems and methods for inducing natural sleep in a subject is provided. In some aspects, the method includes inducing a first sleep state; monitoring a first plurality of characteristics of a brain of the subject to verify the subject is in the first sleep state; inducing a second sleep state after the subject has been in the first sleep state for a predetermined amount of time; and monitoring a second plurality of characteristics of the brain of the subject to verify the subject is in the second sleep state..
The General Hospital Corporation

Composition comprising dual ionic ph-sensitive copolymer for delivering sdf-1 topically to the brain and the use thereof

The present invention relates to a composition for topically delivering sdf-1 into the brain, in which the composition comprises a dual ionic ph-sensitive copolymer and a nerve regeneration and protective factor. In the present invention, when a dual ionic ph-sensitive copolymer containing sdf-1 as a nerve regeneration and protective factor is applied to a patient suffering from ischemic stroke as a drug carrier, it induces the effective delivery of the treatment factor to a topical lesion site, and moreover, the risk factors for adverse effects may be cancelled out, so that it can be effectively used as a novel therapeutic agent for ischemic brain diseases..
Research & Business Foundation Sungkyunkwan University

Pulse dosing regimen and methods of treatment

A novel dosing regimen for erlotinib or a pharmaceutically acceptable salt thereof is described herein. The dosing regimen demonstrates impressive control of central nervous system disease, which is better than that reported with standard dose erlotinib.
Osi Pharmaceuticals Llc

Mao-b inhibitors and rehabilitation

Methods of rehabilitation of neurological disorders, including neurological deficits associated with neurotraumas, such as stroke and traumatic brain injury, and with muscle disorders, that includes administering to a subject a mao-b inhibitor.. .
Dart Neuroscience (cayman) Ltd.

Taxane analogs for the treatment of brain cancer

Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at g2-m interface during mitosis but is not a substrate for mdr protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer..
Tapestry Pharmaceuticals, Inc.

Device with compositions for delivery to the lungs, the oral mucosa and the brain

The present invention provides a passive inhaler for use in treating a number of diseases. The inventor has shown that the compositions comprised in the inhaler can be delivered to the lungs and to the brain in pharmacological relevant dosages, to treat a number of diseases in the lungs and the brain.
Janing Holding Aps

Cranioplasty plate

A cranial plate is provided for use after a craniectomy. The plate is mounted to the skull and protects the brain exposed in the skull opening.
University Of Iowa Research Foundation

Medical image display processing method, medical image display processing device, and program

A diagnosis support device, which is suitable for comparing different diseases, is provided, along with others. In the diagnosis support device, the input of an mri brain image of a subject is received, and a shrinkage score, which represents the degree of shrinkage of the brain, is calculated based on the mri brain image.
Dai Nippon Printing Co., Ltd.

Systems and methods for discovery and characterization of neuroactive drugs

Systems and methods for discovery and characterization of neuroactive drugs are provided. In some aspects, a method for evaluating an effectiveness of a drug administered to a subject includes receiving neurophysiological data acquired from a subject under an administration of a drug, and analyzing the neurophysiological data to generate signatures indicative of brain states induced by the drug.
The General Hospital Corporation

Systems and methods for using eye movements to determine traumatic brain injury

Systems and methods for detecting a traumatic brain injury (tbi). The system comprises a sensing arrangement and a control unit.
Dignity Health

Brain exhibit or model, and using or deploying same

An inflatable exhibit of a brain may include an inflatable infrastructure that is a three-dimensional at least partial representation of the brain. A walk-through passageway may be defined, at least in part, by the inflatable infrastructure, and may extend through at least a portion of the inflatable infrastructure.

Simulation creates a novel dual task paradigm ("divided attention") with enhanced fidelity with dynamic environments for injury reduction, performance enhancement, and rehabilitation

Known dt paradigms fail to replicate the challenges of actual sports; nor do they generate certain fundamental analytics/metrics regarding sports performance under realistic conditions. Simulation creates a novel dt paradigm to detect and manage conditions that may predispose active subjects to increased risk of overtraining, as well movement asymmetries that may expose one to increased risks of brain or orthopedic injuries..

Method and teaching science concepts

A method and apparatus enable a teacher to teach science to a young student using the student's existing life experience acquired knowledge and skill set. A sensory physical activity relating to a concept to be taught is designed for the student to witness and perform in order to provide a sensory experience that is embedded in the brain, the student thereby learning the concept which later can be used to learn a scientific principle.
Knowing Science Llc

Brain matching

This invention, which focuses on personality and aptitude matching by psychophysiologic response to stimuli, is referred to as brain matching. In general terms, this invention starts by selecting highly specialized skill sets and top performer group for each skill set.

Detection of traumatic brain injury

The present invention provides minimally invasive methods of detecting, diagnosing, and assessing neuronal damage associated with traumatic brain injury (tbi) or chronic traumatic encephalopathy (cte). Specific species of micrornas (mirna), small, noncoding rna molecules that play gene regulatory functions, are correlated with cellular damage and oxidative stress following tbi or cte, allowing for rapid, minimally-invasive diagnosis and assessment of brain injury.

Plant lectins as carriers of associated drug substances into animal and human cells

The current invention involves the use of protein lectins produced by plants including the non-toxic carbohydrate binding subunits (b subunits) of plant “ab toxins” (ptb lectins) as delivery vehicles for mobilizing associated drug substances for delivery to animal and human cells. The resulting protein fusions or conjugates retain lectin carbohydrate specificity for binding to cells and cellular trafficking activity so as to deliver an associated drug compound to the site of disease manifestation.
Biostrategies Lc

Natural and synthetic compounds for treating cancer and other diseases

This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
Pacific Arrow Limited

Low frequency neurostimulator for the treatment of neurological disorders

A system for treating neurological conditions by low-frequency time varying electrical stimulation includes an electrical device for applying such low-frequency energy, in a range below approximately 10 hz, to the patient's brain tissue. An implantable embodiment applies direct electrical stimulation to electrodes implanted in or on the patient's brain, while a non-invasive embodiment causes a magnetic field to induce electrical currents in the patient's brain..
Neuropace, Inc.

Compositions, methods, and systems for the synthesis and use of imaging agents

The present invention relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein.
Lantheus Medical Imaging, Inc.

Synthetically functionalized living cells for targeted drug delivery

Uniform, functional polymer patches can be attached to a fraction of the surface area of living individual cells. These surface-modified cells can cross the blood-brain barrier while remaining viable after attachment of the functional patch.
University Of North Carolina Chapel Hill

Pharmaceutical composition comprising modified hemoglobin-based therapeutic agent for cancer targeting treatment and diagnostic imaging

The present invention provides a pharmaceutical composition containing hemoglobin-based therapeutic agent for treating cancer. The hemoglobin moiety can target cancer cells and the therapeutic moiety (i.e.
Vision Global Holdings Ltd.

Methods of treating traumatic brain injury

The present disclosure provides methods for treating traumatic brain injury and other neurological disorders in a subject in need thereof, comprising administering to the subject an effective amount of a composition comprising ghrelin or a ghrelin variant. This invention provides for methods for treating a severe or moderate traumatic brain injury in a patient wherein said method comprises administering to the subject suffering from said severe or moderate traumatic brain injury a therapeutic effective amount of ghrelin or a ghrelin variant or a composition comprising ghrelin or a ghrelin variant so as to treat said severe or moderate traumatic brain injury..
Oxeia Biopharmaceuticals, Inc.

Composition, formulations and methods of making and using botanicals and natural compounds for the promotion of healthy brain aging

The present disclosure provides compositions and formulations comprising botanicals and natural compounds for the promotion of healthy brain aging in adults, especially adult women, and for prevention of age associated neurodegenerative changes resulting in cognitive, memory and executive dysfunction including modulation of the age related predisposition to mild cognitive impairment, alzheimer's disease, hormonal and other dementia related conditions. The present disclosure also provides methods of using the compositions and formulations in treating and preventing neurodegenerative changes resulting in cognitive, memory and executive dysfunction..
The Brain Health Project, Inc.

Topical regional neuro-affective therapy in mammals with cannabinoids

A method of treating a disease state or condition in mammals other than humans via topical brainstem afferent stimulation therapy via the administration of a cannabinoid drug(s) to the back of the neck region and/or spine to provide regional neuro-affective therapy is disclosed. In certain preferred embodiments, the cannabinoid drug(s) are not psychoactive or substantially not psychoactive.
Afgin Pharma, Llc

Spatially selective interventional neuroparticle with magnetoelectric material

An apparatus and method stimulate or sense neurons or groups of neurons in a subject, e.g., a human or animal brain, with positional dependence. This utility is provided in part by utilizing individually-addressable radio-frequency identification (rfid) coils so that locations of those coils in the brain would be monitored and known..
Weinberg Medical Physics, Inc.

Clot evacuation and visualization devices and methods of use

An integrated clot evacuation device having visualization for use in neurosurgical applications, particularly for the evacuation of clots formed as a result of intracranial hemorrhage (ich). The device may further include an integrated camera and light for visualizing the interior of the brain and the clot itself.
Trice Medical, Inc.

Subcortical (thalamic) automated seizure detection for contingent therapy delivery systems and methods

A thalamic medical device system enables automated detection of epileptic seizures and optionally providing contingent thalamic stimulation triggered by automated seizure detection. The thalamic medical device system includes an implantable medical device connected to an electrode assembly and a lead.

Photobiological measurement apparatus

A photobiological measurement apparatus 1 may include a second received light quantity information calculation unit 33 for calculating measurement data relating to cerebral activity, a data display controller for displaying the measurement data for a specified area of a subject's brain, is characterized: is being provided with a reference light-receiving probe 14, which is disposed at a position separated by a first setting distance r1 from the light-transmitting prober 12 that is shorter than a second setting distance r2, and a first received light quantity information calculating unit 32, which calculates skin blood flow data relating to the skin blood flow using first received light quantity information Δa1 from the light transmitting probe 12 to the reference light-receiving probe 14, and in displaying the skin blood flow data at a specified position of the subject's scalp by indicating the measurement position on the subject's scalp and displaying the skin blood data.. .
Shimadzu Corporation

Method and interacting information between smart terminal and wearable device

A method and an apparatus for interacting information between a smart terminal and a wearable device are provided. The method includes: acquiring first control information containing behavior information of a tester; acquiring second control information containing brain wave information of the tester; comparing the first control information with the second control information to obtain a comparison result; and executing the first control information when the comparison result indicates that the first control information is consistent with the second control information.
Zte Corporation

Method and examining brain injury due to impact

An impact test system includes a head model having a head exterior component; a skull component; a brain component; a fluid component; an interior cavity surface; and a translucent cover, wherein the head model is coupled with a mount, the brain component and fluid components are configured within the interior cavity, and wherein the translucent cover is configured over a portion of the brain component and fluid component. A mount is configured to a least partially restrain the head model.
Villanova University

Low affinity blood brain barrier receptor antibodies and uses thereof

The present invention relates to antibodies that bind blood brain barrier receptors (bbb-r) and methods of using the same.. .
Genentech, Inc.

Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease

The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of alzheimer's disease and related tauopathies.
Axon Neuroscience Se

Gamma-diketones as wnt/beta -catenin signaling pathway activators

The present disclosure provides γ-diketones or analogs thereof, that activate wnt/β-catenin signaling and thus treat or prevent diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries or spine injuries, brain atrophy/neurological disorders related to the differentiation and development of the central nervous system, including parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; otic disorders like cochlear hair cell loss; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, such as hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .
Samumed, Llc

Brainwave virtual reality apparatus and method

New human bio-sensors in a virtual reality headset can be worn comfortably for extended periods of time, detecting brain, nerve, ocular, muscle or other bio-signals. Recording raw data, amplification, digital conversion, filtering, support subsequent manipulation by iteratively creating multiple interpretation maps.

Method for transiently disrupting a region of the blood-brain barrier of a human

The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (bbb) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (us) beam with a pressure level higher than 1 mpa and a resonance frequency ranging from 0.5 to 1.5 mhz..
Universite Pierre Et Marie Curie (paris 6)

Systems and methods for pain treatment using spinal nerve magnetic stimulation

Described are methods, devices, and systems for a novel, easy-to-use treatment for pain that does not involve medication. Methods and devices herein use repetitive magnetic fields that desensitize the spinal nerve, thereby affecting transmission of pain signals from the treatment location to the brain..
Kosivana Holdings Limited

Wireless midfield systems and methods

Implantable devices and/or sensors can be wirelessly powered by controlling and propagating electromagnetic waves in a patient's tissue. Such implantable devices/sensors can be implanted at target locations in a patient, to stimulate areas such as the heart, brain, spinal cord, or muscle tissue, and/or to sense biological, physiological, chemical attributes of the blood, tissue, and other patient parameters.
The Board Of Trustees Of The Leland Stanford Junior University

Device and effective invasive neurostimulation by means of varying stimulus sequences

A device is provided for stimulating neurons that includes an implantable stimulation unit that generates stimuli in multiple stimulation elements. The stimulation unit generates the stimuli to stimulate a neuron population in the brain and/or spinal cord of a patient using the stimulation elements.
Forschungszentrum Juelich Gmbh

Systems and methods for disrupting neuronal oscillation using deep brain stimulation

The present disclosure provides systems and methods for disrupting neuronal oscillations. A neurostimulation system includes a stimulation lead comprising at least one contact, and an implantable pulse generator (ipg) communicatively coupled to the stimulation lead and configured to cause stimulation to be applied to a patient using no more than two contacts of the stimulation lead by causing a first burst of stimulation to be delivered, and causing a second burst of stimulation to be delivered within a neuronal refractory period that follows the first burst of stimulation..
Pacesetter, Inc.

Medical therapy target definition

In some examples, a system may include a plurality of electrodes, electrical stimulation circuitry, and a controller. The controller may be configured to select one or more parameters of therapy to be delivered to a brain of a patient and to control the electrical stimulation circuitry to deliver the therapy to the brain of the patient based on the selected parameters and via a first one or more electrodes of the plurality of electrodes.
Medtronic, Inc.

Injectable neurosteroid formulations containing nanoparticles

Where the variables r1-r9 and x are defined herein and at least one surface stabilizer. The surface stabilizer can be a polymeric surface stabilizer such as hydroxyethyl starch, dextran, or povidone.

Angiotensin in treating brain conditions

The present invention provides, among other things, methods and compositions for treating brain conditions. In some embodiments, the methods include administering to a subject suffering from or susceptible to a brain condition an angiotensin (1-7) peptide via either an intravenous or subcutaneous route of administration..
Tarix Pharmaceuticals Ltd.

Methods for treating brain metastasis

The present invention relates to methods for treating brain metastasis by inhibiting gap junction functionality. It is based, at least in part, on the discovery that cancer cells expressing protocadherin 7 and connexin 43 form gap junctions with astrocytes that promote the growth of brain metastases, and that inhibition of protocadherin 7 and/or connexin 43 expression in cancer cells reduce progression of brain metastases.
Memorial Sloan-kettering Cancer Center

Self-micellizing fatty acids and fatty acid ester compositions and their use in the treatment of disease states

Described herein are compositions including at least one omega-3 fatty acid (either in the triglyceride, ester or free fatty acid ester form) and at least one surface active agent; wherein the compositions form micelles when in contact with an aqueous medium. Also provided are methods of administering to a subject a composition including at least one omega-3 fatty acid (either in the triglyceride, ester or free fatty acid ester form) and at least one surface active agent, wherein the compositions form micelles when in contact with an aqueous medium, and the bioavailability of the omega-3 fatty acid is substantially independent of a food effect.
Sancilio & Company, Inc.

Glutamine enriched nutritional composition for preterm infants

The present invention relates to the use of nutritional compositions enriched in glutamine to improve structural and functional brain development in preterm and/or low birth weight infants.. .
N.v. Nutricia

Nanovectors for penetrating brain tumor tissues to conduct gene therapy

A method of selectively targeting a cell with a therapeutic agent, the method comprising: targeting a cell with a nanospear, puncturing the cell with said nanospear; releasing a therapeutic agent from said nanospear, wherein said therapeutic agent enters said cell, thereby effecting the efficacy of said cell.. .
University Of Houston System

Elevation timing head up cpr

A method for performing cardiopulmonary resuscitation (cpr) includes elevating the head, heart and shoulders of an individual from a starting elevation angle to a final elevation angle greater than zero degrees relative to horizontal while performing cpr by repeatedly compressing the chest. The method includes elevating the brain within a time period selected to be slow enough to permit a sufficient amount of blood to flow to the brain throughout the elevation time period.

Optimal dosages for low energy shock wave treatment of vital organs

The treatment of various sensitive organs with low energy acoustic shockwaves has been proposed. However, the prior art is lacking in guidance as to what constitutes an efficacious minimum dosage or a safe maximum dosage for various target organs and tissues.
The Regents Of The University Of California

Virpet - combination of virtual reality and pet brain imaging

Various methods, systems and apparatus are provided for brain imaging during virtual reality stimulation. In one example, among others, a system for virtual ambulatory environment brain imaging includes a mobile brain imager configured to obtain positron emission tomography (pet) scans of a subject in motion, and a virtual reality (vr) system configured to provide one or more stimuli to the subject during the pet scans.
West Virginia University

Method and prediction of epileptic seizures

A system for predicting epileptic seizures includes sensors operable to record a wearer's brain activity. The sensors electronically communicate with a processor configured to receive and store output eeg oscillations and activities.
University Of Windsor

Coated biosensor and preserving biosensor during implantation into the brain or other tissues

Provided herein is a coated biosensor and a method of preserving a coated biosensor to protect it during implantation into the brain or other tissues by coating the biosensor with a protective coating.. .
Diagnostic Biochips, Inc.

Early detection of neurodegenerative disease

Embodiments of the present systems and methods may provide a non-invasive system to measure and integrate behavioral and cognitive features enabling early detection and progression tracking of degenerative disease. For example, a method of detecting neurodegenerative disease may comprise measuring functioning of at least one of the motor system, cognitive function, and brain activity of a subject during everyday life and analyzing the gathered at least one motor system data, cognitive function data, and brain activity data of the subject..

Neuroanalytic, neurodiagnostic, and therapeutic tools

Embodiments may provide multimodal diagnostic systems and methods for detecting neurological disorders, such as alzheimer's disease (ad), parkinson's disease (pd), depression, ptsd, schizophrenia, dementia and many others. For example, a system for monitoring brain activity may comprise a plurality of sensors, each adapted to monitor a physical or physiological parameter and output a signal representing the monitored physical or physiological parameter, wherein the plurality of sensors includes at least one sensor configured to monitor a brain activity parameter, a data collection device adapted to receive the plurality of signals from the plurality of sensors and to process the signals to form digital data representing the monitored physical or physiological parameters, and a data processing device adapted to process digital data representing the monitored physical or physiological parameters to determine presence of a neurological disorder or condition..

Leveraging on local and global textures of brain tissues for robust automatic brain tumor detection

A method for performing cellular classification includes generating a plurality of local dense scale invariant feature transform (sift) features based on a set of input images and converting the plurality of local dense sift features into a multi-dimensional code using a feature coding process. A first classification component is used to generate first output confidence values based on the multi-dimensional code and a plurality of global local binary pattern histogram (lbp-h) features are generated based on the set of input images.
Siemens Healthcare Gmbh

Apparatus for improving vision acuity in points of interest of the visual field

Eyewear for enhancing the contrast sensitivity of the human vision system through the use of lenses subdivided in areas of different light filtration properties arranged in specialized patterns, called multi-filters patterns, are provided. Of the multiple filtration areas, or filters, that compose each multi-filters patterns, one or more filters heavily reduces or totally block light arriving from some areas of the visual field of the eyes , while other filters lightly reduce or totally allow light from other areas of the same visual field.

Methods and kits for detecting and diagnosing neurotrauma

Methods and kits for detecting and diagnosing neurotrauma (e.g., traumatic brain injury, stroke, or spinal cord injury) are provided. These methods rely on the determination of lysophosphatidic acid (lpa) and/or lpa metabolite levels in patient samples following suspected injury..

Method for producing cerebellar progenitor tissue

The present invention provides a method for producing a human cell aggregate containing a midbrain-hindbrain boundary neural progenitor tissue, including subjecting an aggregate of human pluripotent stem cells to suspension culturing in a serum-free medium containing insulin, and treating, in the suspension culturing, the aggregate of human pluripotent stem cells or a human cell aggregate derived therefrom with a rock inhibitor, a tgfβ signal inhibitor, and a first fibroblast growth factor. Furthermore, the human cell aggregate containing the midbrain-hindbrain boundary neural progenitor tissue is subjected to suspension culturing in a serum-free medium to induce formation of a neuroepithelial structure by neural progenitor in the neural progenitor tissue, whereby the human cell aggregate containing the cerebellar plate tissue can be obtained..
Sumitomo Chemical Company, Limited

Modulation of leukocyte activity in treatment of neuroinflammatory degenerative disease

Methods for treating and reducing the progression of neurodegenerative diseases, including, without limitation alzheimer's disease, are provided. The methods of the invention reduce or deplete neutrophil/myeloid cells in the region of the brain by blocking neutrophil/myeloid cell adhesion and interaction with the vascular endothelium, by blocking infiltration of neutrophil/myeloid cells into the brain, by reducing motility of neutrophil/myeloid cells in the parenchyma, by blocking aβ-induced activation and adhesion of neutrophil/myeloid cells, and/or by blocking aβ-induced integrin activation, degranulation and/or ros release in neutrophil/myeloid cells..
Leuvas Therapeutics

Novel chromone oxime derivative and its use as allosteric modulator of metabotropic glutamate receptors

The present invention provides a novel chromone oxime derivative of formula (i), which is a modulator of nervous system receptors sensitive to glutamate and, furthermore, presents an advantageously high brain penetration upon oral administration. The invention also relates to a pharmaceutical composition containing this compound, and to its use for the treatment or prevention of conditions associated with altered glutamatergic signalling and/or functions, or conditions which can be affected by alteration of glutamate level or signalling, particularly acute and chronic neurological and/or psychiatric disorders..
Prexton Therapeutics Sa

Audio tone programmed hygienic and therapeutic sleep and wake eye mask having remotely controlled sunrise and sunset multimodes

An eye mask for use to wake up and/or to go to sleep provides ease of cleaning or replacement without damaging electrical or optical components; different user selectable sunrise and sunset illumination modes respectively having blue-shifted and red-shifted spectra simulating natural sunrises and sunsets to assimilate the sleep/wake cycle to the natural rhythms of day and night; sunset and/or sunrise illumination modes that oscillate with fixed period or sequentially changing periods that correspond to brainwave frequencies that respectively facilitate going to sleep and/or waking and synergistically co-operate with corresponding sunset or sunrise light fields to help the user to fall into restful sleep or to awake refreshed and alert; and audio tone programming of illumination mode and treatment time and/or duration of therapy by a remote tone control generator.. .
Headwaters Research & Development Inc

Apparatus and methods for improving health outcomes of preterm infants

Adverse effects of pain in a premature infant, especially a very or extremely premature infant may be ameliorated by exposing the infant to stimuli comprising one or more of vertical oscillating motion simulating breathing, skin contact with an interface that mimics human skin and exposure to sounds and/or vibrations that simulate heartbeats. A device including a movable platform provides such stimuli within a neonatal intensive care incubator.
British Columbia Cancer Agency Branch

Systems and methods for attracting and trapping brain cancer cells

Described herein are systems and methods for attracting and trapping cancer cells at a specific site where focal radiation and/or surgical resection and/or chemotherapeutics can eliminate them.. .
Geisinger Health System

Brain and neural treatments comprising peptides and other compositions

The present invention generally relates to compositions and methods for treatment of subjects in need of muscle growth, muscle repair, improved muscular and neuromuscular control, and treatments for neuromuscular and neurological disorders, including brain disorders. In some cases, the composition may include nitric oxide and/or peptides such as thyrotropin-releasing hormone (trh) and/or gnrh (gonadotropin-releasing hormone).
Transdermal Biotechnology, Inc.

Method for treating parkinson disease, neurodegenerative disorders, and autoimmune diseases

The embodiments herein relate to a therapeutic method for the treatment of parkinson disease, other neurodegerative disorders, and autoimmune diseases. The method includes providing sodium thiosulfate through any method of administration (orally, intravenously, through inhalation, intravesically, vaginally, rectal route, sublingually, ophthalmically, or topically) and is given with one or more pharmaceutically acceptable carriers or excipients.

Dnp and dnp prodrug treatment of neuromuscular, neurodegenerative, autoimmune, developmental, traumatic brain injury, concussion, dry eye disease, hearing loss and/or metabolic diseases

A composition and method of treatment of neuromuscular, neuromuscular degenerative, neurodegenerative, autoimmune, developmental, traumatic, hearing loss related, and/or metabolic diseases, including spinal muscular atrophy (sma) syndrome (sma1, sma2, sma3, and sma4, also called type i, ii, iii and iv), traumatic brain injury (tbi), concussion, keratoconjunctivitis sicca (dry eye disease), glaucoma, sjogren's syndrome, rheumatoid arthritis, post-lasik surgery, anti-depressants use, wolfram syndrome, and wolcott-rallison syndrome. The composition is selected from the group consisting of 2,3-dnp, 2,4-dnp, 2,5-dnp, 2,6-dnp, 3,4-dnp, or 3,5-dnp, bipartite 2,3-dinitrophenol, 2,4-dinitrophenol, 2,5-dinitrophenol, 2,6-dinitrophenol, 3,4-dinitrophenol, or 3,5-dinitrophenol (2,3-dnp, 2,4-dnp, 2,5-dnp, 2,6-dnp, 3,4-dnp, or 3,5-dnp) prodrugs; gemini prodrugs, bioprecursor molecules, and combinations thereof.
The Board Of Trustees Of The University Of Arkansas Acting For And On Behalf Of The Universit

Detection of disease conditions and comorbidities

A new computational approach may provide improved detection of disease conditions and comorbidities, such as ptsd, parkinson's, alzheimer's, depression, etc. For example, in an embodiment, a computer-implemented method for detecting a disease condition may comprise receiving a plurality of data streams, each data stream representing a measurement of a brain activity comprising physical and chemical phenomena and performing pattern analysis on the plurality of data streams to detect at least one fundamental code unit of a brain code corresponding to a disease condition based on a combination of the plurality of data streams..

Method for improved seizure detection

A method for improved seizure detection includes capturing neural data for a first set of brain regions; calculating inter-region correlations between pairs of the first set of brain regions from the neural data; detecting a period of hyposynchrony from the inter-region correlations; after detecting the period of hyposynchrony, detecting a period of hypersynchrony from the inter-region correlations; and based on a transition from the period of hyposynchrony to the period of hypersynchrony, detecting a first seizure.. .
Sbb Research Group Llc

Brain dysfunction evaluation system, brain dysfunction evaluation method, and program

A system for evaluating the degree of brain dysfunction of a subject, such as a decline in cognitive function, calculates a difference in movement functions between both hands in a coordination movement. The system includes a storage device for storing time-series data on a finger movement task of each of both hands of a test subject acquired by a movement sensor; a data processing device for analyzing the time-series data stored in the storage device; and a display device for displaying an analysis result analyzed by the data processing device.
Hitachi Maxell, Ltd.

Concussive reduction helmet attachment(s) translational axial rotation control and bracing system (tarcbs).

A concussive reduction helmet attachment system which reduces the total area available for acceleration of the head in all axis, specifically designed to provide a measured reduction in accelerative force at the critical moment within the blow. A helmet attachment that reduces the factors that contribute to mechanical transfer of energy to the brain thereby reducing potential traumatic brain injury, concussions and neck compression.

Brain stimulation system and uses thereof

The present disclosure provides devices, systems and methods for enhancing the cognitive activity/ability of a user by providing a watch-only stimulation session with visual features configured to induce stimulation to different brain areas, thereby stimulating a predefined path within the brain of the user.. .
Wize-i Ltd

Methods, systems, and compositions for cell-derived/vesicle-based microrna delivery

Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected micrornas, including but not limited to, mir-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian brain or neurologic injuries and diseases, including in human beings..
Henry Ford Health System

Blood-brain barrier disrupting agents and uses thereof

The present invention relates to blood-brain barrier disrupting agents containing a modified serum albumin comprising serum albumin. The present invention further relates to pharmaceutical compositions comprising said agents and use thereof for the treatment of brain diseases and disorders..
Yeda Research And Development Co. Ltd.

Neuroactive steroids, compositions, and uses thereof

Described herein are steroids of formula (i): and pharmaceutically acceptable salts thereof; wherein r1, r2a, r2b, r3, r4, r5a, r5b, r6, and z are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus..
Sage Therapeutics, Inc.

Devices and methods for optimized neuromodulation and their application

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce long-term potentiation (ltp) or long-term depression (ltd). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts.

Variable frequency stimulation therapy method

The disclosure relates to an electrical stimulation therapy method. The method includes applying a variable frequency stimulation pulse to target nerve tissue of the patient suffering from dysfunction of a nerve circuit in the brain selected from the group consisting of motor circuit, associative circuit and limbic circuit, wherein the variable frequency stimulation pulse comprises at least two kinds of electrical stimulation pulse trains at different frequencies; and each of the at least two kinds of alternate electrical stimulation pulse trains in each of the plurality of pulse train periods has a duration in a range from about 0.1 seconds to about 60 minutes.
Tsinghua University

Multi-electrode array for spinal cord epidural stimulation

In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.. .
The Regents Of The University Of California

Methods of fabricating a multi-electrode array for spinal cord epidural stimulation

In certain embodiments an electrode array for epidural stimulation of the spinal cord is provided where the array comprises a plurality of electrodes disposed on a flexible polymer substrate; said electrodes being electrically connected to one or more lead wires and/or connection points on an electrical connector; where the electrodes of said array are bonded to said polymer so that the electrodes can carry an electrical stimulation signal having a voltage, frequency, and current sufficient to provide epidural stimulation of a spinal cord and/or brain in vivo or in a physiological saline solution, without separation of all or a part of an electrode from the polymer substrate.. .
The Regents Of The University Of California

Polyol-based osmotic polydixylitol polymer gene transporter and use thereof

The present invention relates to polydixylitol polymer based gene transporter (pdxyp) and a preparation method thereof. Further, the present invention relates to a nucleic acid delivery complex where the nucleic acids for treatment are conjugated to the gene transporter and a pharmaceutical composition for gene therapy including the complex as an active ingredient.
Seoul National University R&db Foundation

Longevity enhancement induced by repetitive injections of botulinum toxin (centurion effect)

Described herein is a novel application involving the use of therapeutic or cosmetic formulations of botulinum toxin involving an increase and enhancement of longevity in human subjects. The inventors are physicians who have used this agent for the past 30 years for many indications and has treated a large number of patients for periods of 20-30 years, many over the age of 60 at therapy initiation for medical and aesthetic conditions.

19-nor c3, 3-disubstituted c21-n-pyrazolyl steroids and methods of use thereof

And pharmaceutically acceptable salts thereof; wherein , r1, r2, r3a, r3b, r4a, r4b, r5, r6, and r7 are as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of cns-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus..

B- and y -diketones and y -hydroxyketones as wnt/ b -catenin signaling pathway activators

Which activates wnt/β-catenin signaling and thus treats or prevents diseases related to signal transduction, such as osteoporosis and osteoarthropathy; osteogenesis imperfecta, bone defects, bone fractures, periodontal disease, otosclerosis, wound healing, craniofacial defects, oncolytic bone disease, traumatic brain injuries related to the differentiation and development of the central nervous system, comprising parkinson's disease, strokes, ischemic cerebral disease, epilepsy, alzheimer's disease, depression, bipolar disorder, schizophrenia; eye diseases such as age related macular degeneration, diabetic macular edema or retinitis pigmentosa and diseases related to differentiation and growth of stem cell, comprising hair loss, hematopoiesis related diseases and tissue regeneration related diseases.. .

Beta-substituted gamma-amino acids and analogs as chemotherapeutic agents

β-substituted γ-amino acids, β-substituted γ-amino acid derivatives, and β-substituted γ-amino acid analogs and (bio)isosteres and their use as chemotherapeutic agents are disclosed. The β-substituted γ-amino acid derivatives and β-substituted γ-amino acid analogs and (bio)isosteres are selective lat1/4f2hc substrates, capable of passing through the blood-brain barrier, and exhibit rapid uptake and retention in tumors expressing the lat1/4f2hc transporter.
Quadriga Biosciences, Inc.





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