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This page is updated frequently with new Brain-related patent applications.

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 Mobile terminal and control method therefor patent thumbnailMobile terminal and control method therefor
A mobile terminal and a control method therefor are disclosed. The mobile terminal according to one embodiment of the present invention comprises: a brainwave detection unit; a brain wave recognition unit; a display unit; and a control unit, wherein the control unit controls the display unit so as to display a first screen corresponding to a first application currently being executed, controls the brainwave detection unit so as to detect the brain wave, controls the brainwave recognition unit so as to recognize the detected brainwave, on the basis of the first application, and controls the display unit so as to display a second screen which differs from the first screen with respect to at least a part thereof, on the basis of the recognized result of the brainwave..
Lg Electronics Inc.


 Blood biomarker for early blood brain barrier disruption in ischemic stroke patent thumbnailBlood biomarker for early blood brain barrier disruption in ischemic stroke
Methods and apparatus for determining blood brain barrier (bbb)damage and treating patients who may have suffered from bbb damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood.
Stc.unm


 Fungal-specific metalloproteases and uses thereof patent thumbnailFungal-specific metalloproteases and uses thereof
The present invention relates to methods of reducing, delaying, preventing and/or inhibiting the progression of a cryptococcus infection into the central nervous system (cns) of a subject by inhibiting the activity of a m36 fungalysin metalloprotease (e.g., mpr1) secreted by the cryptococcus. The invention further provides methods of increasing, promoting and/or enhancing delivery of a therapeutic agent across the blood-brain-barrier, comprising systemically administering the therapeutic agent in conjunction with a m36 fungalysin metalloprotease (e.g., mpr1), or an enzymatically active fragment thereof..
The Regents Of The University Of California


 Hcbi, msbi, mssi and cmi sequences as an early marker for the future development of cancer and diseases of the cns and as a target for the treatment and prevention of these diseases patent thumbnailHcbi, msbi, mssi and cmi sequences as an early marker for the future development of cancer and diseases of the cns and as a target for the treatment and prevention of these diseases
Described are hcbi (healthy cattle blood isolate), msbi (multiple sclerosis brain isolate), mssi (multiple sclerosis serum isolate) and cmi (cow milk isolate) nucleotide sequences as well as probes and primers comprising part of said nucleotide sequences and antibodies against polypeptides encoded by said nucleotide sequences. Said compounds are useful as early markers for the future development of cancer and diseases of the cns (multiple sclerosis ms, prion-linked diseases, amyotrophic lateral sclerosis, transmissible spongiforme encephalitis, parkinson's disease, alzheimer disease) and should represent targets for treatment and prevention..
Deutsches Krebsforschungszentrum


 Peripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system patent thumbnailPeripherally restricted gaba positive allosteric modulators for the treatment of irritable bowel syndrome and other ailments of the peripheral nervous system
The present invention provides compounds and compositions which are positive allosteric modulators of gaba-a receptors that selectively target the peripheral nervous system and organs of the body, and which do not pass through the blood-brain barrier. The compounds and compositions of the present invention are useful for treatment of diseases or disorders which are mediated by gaba-a neuronal activity, such as, for example, visceral pain, gut motility, irritable bowel syndrome, functional abdominal pain, functional idiopathic diarrhea, inflammatory bowel diseases, drug induced pain, bile salt malabsorption, lactase or other carbohydrate intolerance..
Lieber Institute, Inc.


 Image-guided irrigating suction cannula for removal of intracerebral hemorrhage and other lesions patent thumbnailImage-guided irrigating suction cannula for removal of intracerebral hemorrhage and other lesions
A minimally invasive surgery device for image-guided removal of lesions in the brain by providing suction and irrigation through a small cranial opening. One particular use is for evacuation of intracerebral hemorrhage.
The Regents Of The University Of California


 Nanoparticle contrast agent for early diagnosis of alzheimer's disease by magnetic resonance imaging (mri) patent thumbnailNanoparticle contrast agent for early diagnosis of alzheimer's disease by magnetic resonance imaging (mri)
The disclosure herein relates to a novel nanoparticle that can cross the blood-brain barrier and form a bond with amyloid plaques and other related protein aggregates for detection by magnetic resonance imaging (mri). The compositions, methods of making, and methods of use set forth herein also provide a non-invasive means for diagnosing alzheimer's disease at an early stage..
The Chinese University Of Hong Kong


 Compositions and methods for the repair of myelin patent thumbnailCompositions and methods for the repair of myelin
Described are oxysterols, pharmaceutical compositions including the oxysterols, and methods of using the oxysterols and compositions for treating diseases and/or disorders related to myelin injury, such as neonatal brain injury, traumatic brain injury, spinal cord injury, cerebral palsy, seizures, cognitive delay, multiple sclerosis, stroke, autism, leukodystrophy, schizophrenia and bipolar disorder.. .
Duke University


 Preparation and application of flavonol as brain-targeting synergist patent thumbnailPreparation and application of flavonol as brain-targeting synergist
The present invention discloses a preparation and application of flavonol as a brain-targeting synergist. After long-term repeated studies, the inventors have found that some flavonol compounds, particularly kaempferide, rutin, troxerutin, myricetin, hesperidin, and hydroxy derivatives thereof, in particular their glycoside, ester, ether derivatives, can promote the drug molecules that have therapeutic or healthcare effect, such as ginsenoside, stilbene glucoside, resveratrol, levodopa, edaravone, vinpocetine, nicergoline, citicoline, oxiracetam, to enter brain tissues, to dramatically enhance drugs concentrations in the brain tissues and effective enhance the efficacy of drugs without increasing the plasma concentration..
Guangdong Pharmaceutical University


 Continuous administration of levodopa and/or dopa decarboxylase inhibitors and compositions for same patent thumbnailContinuous administration of levodopa and/or dopa decarboxylase inhibitors and compositions for same
Disclosed herein are for example, liquid aqueous compositions that include for example an ester or salt of levodopa, or an ester or salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, parkinson's disease, secondary parkinsonism, huntington's disease, parkinson's like syndrome, psp, msa, als, shy-drager syndrome, dystonia, and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of levodopa and/or carbidopa or ester and/or salt thereof.. .
Neuroderm, Ltd.


Frequency-multiplexed speech-sound stimuli for hierarchical neural characterization of speech processing

A system and method for generating frequency-multiplexed synthetic sound-speech stimuli and for detecting and analyzing electrical brain activity of a subject in response to the stimuli. Frequency-multiplexing of speech copora and synthetic sounds helps the composite sound to blend into a single auditory object.
The Regents Of The University Of California

Method and fixation, alignment, and/or saccadic measurements to identify and/or track brain function

A device can include a body having a top surface, an opposing bottom surface, a first face and an opposing second face. The first face can have an opening therein.
Rebiscan, Inc.

Identification, diagnosis, and treatment of neuropathologies, neurotoxicities, tumors, and brain and spinal cord injuries using electrodes with microvoltammetry

The present invention relates to devices and methods of use thereof for detection of biomolecules, in vitro, in vivo, or in situ. The invention relates to methods of diagnosing and/or treating a subject as having or being at risk of developing a disease or condition that is associated with abnormal levels of one or more biomolecules including, but not limited to, inter alia, epilepsy, diseases of the basal ganglia, athetoid, dystonic diseases, neoplasms, parkinson's disease, brain injuries, spinal cord injuries, and cancer.
New York University School Of Medicine

Helmet to reduce traumatic brain injuries

A protective helmet includes a plurality of fluid filled bladders, impact sensors, valves, and pumps wherein the helmet absorbs energy from an impact to protect a person wearing the helmet from traumatic brain injury. The bladders expel fluid in response to a triggering event such as energy from an impact detected as a pressure spike event and/or detected as an acceleration event.

Methods and detecting and handling split brain issues in a link aggregation group

Methods and apparatus for operating a virtual node in a lag that includes a first virtual node and a second virtual node are disclosed. The first virtual node includes at least a first fellow node and a second fellow node.
Telefonaktiebolaget Lm Ericsson (publ)

System for the distributed collection of brain health information

A system is provided for collecting medical data about a subject between visits to a health care professional. The system includes a medical records database that stores patient data for access by the health care professional and an interactive and distributed data collection system provided to a team of collaborators (doctors, parents, teachers, etc.) who are to collect data about the subject between visits to a health professional.
Cerora, Inc..

Method for a brain region location and shape prediction

A volumetric segmentation method is disclosed for brain region analysis, in particular but not limited to, regions of the basal ganglia such as the subthalamic nucleus (stn). This serves for visualization and localization within the sub-cortical region of the basal ganglia, as an example of prediction of a region of interest for deep brain stimulation procedures.
Surgical Information Sciences, Inc.

Method and system for supporting a medical brian mapping procedure

A data processing method performed by a computer for supporting a medical brain mapping procedure, comprising the steps of receiving a microscope image of a patient's cortex and superimposing stimulation response marks onto the microscope image, wherein a stimulation response mark indicates the patient's response to an electrical stimulation of the cortex by a stimulation probe at a position associated with the stimulation response mark.. .
Brainlab Ag

Metabolic biomarkers of autism

This invention provides methods and biomarkers for diagnosing autism by identifying cellular metabolites differentially produced in autistic patient samples versus non-autistic controls. Methods for identifying a unique profile of metabolites present of secreted in brain tissue, cerebrospinal fluid, plasma, or biofluids of autistic samples are described herein.
Stemina Biomarker Discovery, Inc.

5-ala for detection of brain tumors

The present disclosure relates to methods for detecting brain tumors and assessing the recurrence of such tumors by administering a pharmaceutical composition comprising 5-aminolevulinic acid (5-ala) and detecting the conversion of 5-ala to protoporphyrin ix (ppix) associated with brain-derived microparticles.. .
Pioma, Inc.

Conditionally active biological proteins

This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at some physiological conditions. For example, conditionally active biologic proteins are active in tumors, but virtually inactive at other body parts, or conditionally active antibodies cap able of crossing blood-brain-barrier..
Bioatla, Llc

Novel compositions useful in treating brain-related diseases or disorders and methods using same

The present invention provides compounds useful for treating or preventing a brain-related disease or disorder. The present invention further provides a method of treating or preventing a brain-related disease or disorder in a patient, comprising administering to the patient a pharmaceutical composition comprising at least one compound of the invention.
Drexel University

Device and low-noise magnetic neurostimulation

The present invention relates to a device and a method for the stimulation of nerve and muscle cells according to the principle of magnetic stimulation, wherein the invention has a significantly reduced sound emission for the same stimulus intensity when compared to the prior art. The sound emission in the form of a click noise, which, in the magnetic stimulation, determines on the one hand an important safety risk and on the other hand causes an undesired, uncontrollable sensory-auditory brain stimulation is reduced in the present invention by increasing the frequency of a substantial portion of the spectrum of the pulse, preferably up to or beyond the human hearing range.

Transcranial magnetic lesioning of the nervous system for relief of intractable pain

Intractable pain is a horrific cause of world-wide suffering. Nervous system excitation is a hallmark of intractable pain and lesioning of excited pathways and structures can produce sustained analgesia.

Method and system for treating patients with alzheimer disease

A method and system for treating patients with alzheimer disease includes steps and equipment operative for subjecting a patient suffering from alzheimer disease to a non-invasive action directed toward a patient's brain and causing a cavitation process in the patient's brain liquid in the vicinity of lesions and thereby destroying the latter.. .

Method and virtual reality-based mindfulness therapy

In one embodiment, there is a computer-implemented method for delivering therapy to a user, comprising: providing data representative of an initial sensory stimulus to a sensory stimulus device and causing the sensory stimulus device to provide the initial sensory stimulus to the user; receiving alpha wave biometric data of the user from a brain electrical activity sensor while the sensory stimulus device provides the initial sensory stimulus; determining whether the alpha wave biometric data meets sensory stimulus adjustment criteria; if the alpha wave biometric data meets sensory stimulus adjustment criteria, adjusting the sensory stimulus provided to the user by providing data representative of an adjusted sensory stimulus to the sensory stimulus device and causing the sensory stimulus device to provide the adjusted sensory stimulus; and if the alpha wave biometric data fails to meet sensory stimulus adjustment criteria, continue causing the sensory stimulus device to provide the initial sensory stimulus to the user.. .
Cigna Intellectual Property, Inc.

Controlled release delivery system for nasal applications and treatment

This invention relates to a gel formulation for nasal administration of a controlled release formulation of hormones to the systemic circulation and/or to the brain. The special lipophilic or partly lipophilic system of the invention leads to higher bioavailability of the active ingredient caused by sustained scrum levels in plasma but also leads to a more favorable serum level profile.
Mattern Pharma Ag

Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin

Compositions tor prevention or treatment of non-inflammatory neuronal damage from brain trauma and strokes are provided, and the compositions contain a therapeutically effective amount of a compound selected from the group consisting of menthol, linalool, icilin and combinations thereof. Methods for treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes are also provided, and the methods include administering such compositions..
Nestec S.a.

Compositions and methods for minimizing or reversing agonist-induced desensitization

Methods and compositions are provided for preventing or reversing loss of the therapeutic effect of a drug, where the loss is associated with the repeated administration of the drug to a patient. The method includes administering to the patient a dopamine receptor agonist or partial agonist or a drug that increases the extracellular level of dopamine by enhancing release of dopamine, decreasing the removal of dopamine from the extracellular space, enhancing the synthesis of dopamine within the brain, or decreasing metabolic degradation of dopamine; and also administering to the patient an opioid receptor antagonist in an ultra-low dose amount, wherein the ultra-low dose amount is effective to prevent or reverse loss of therapeutic effects associated with the repeated administration of the drug to the patient.
Pharmorx Therapeutics, Inc.

Compounds for treating brain cancer

For use in the treatment of a brain cancer selected from a mgmt positive astrocytic brain tumor, a metastatic brain cancer and primary cns lymphoma and a method of treating said brain cancers in a patient in need thereof comprising administering to the patient said compound of formula i or a pharmacologically acceptable salt thereof.. .

Improved embolic protection device and method

A catheter device is disclosed comprising; an elongate sheath (503) with a lumen and a distal end for positioning at a heart valve (6), an embolic protection device (200) for temporarily positioning in the aortic arch for deflection of embolic debris from the ascending aorta to the descending aorta, said embolic protection device is connectable to a transluminal delivery unit (130) extending proximally from a connection point (131), and having: a frame with a periphery, a blood permeable unit within said periphery for preventing embolic particles from passing therethrough with a blood flow downstream an aortic valve into side vessels of said aortic arch to the brain of a patient, and at least one tissue apposition sustaining unit (300, 350) extending from said catheter, into said aortic arch, and being attached to said embolic protection device at a sustaining point (502), for application of a stabilization force offset to said connection point at said embolic protection device, such as at said periphery, and for providing said stabilization force towards an inner wall of said aortic arch, away from said heart, and in a direction perpendicular to a longitudinal extension of said periphery, when said catheter device is positioned in said aortic arch, such that tissue apposition of said periphery to an inner wall of said aortic arch is supported by said force for improving stability and peripheral sealing. In addition related methods are disclosed..
Swat Medical Ab

Method for treating aortic arch diseases

In a method for treating an aortic arch disease, after an intraoperative stent is expanded in an aorta and at least one arch branch vessel, and before the vessel is exactly anastomosed with an incision, by blocking a thoracic aorta between the incision and an arch branch vessel closest to the incision, the intraoperative stent in the thoracic aorta is also blocked, so that blood is prevented from flowing from the incision, and a proximal orifice of the intraoperative stent, and the low body perfusion may be recovered in advance, thereby reducing the circulatory arrest time of the low body perfusion and reducing the time of ischemia of visceral organs and lower limbs of a patient. Meanwhile, the flow of a cerebral perfusion through the right axillary artery may be recovered to a normal flow in advance, and the time of ischemia of the brain of the patient is reduced..
Lifetech Scientific (shenzhen) Co., Ltd.

Eeg glasses (electroencephalographic eyewear)

This invention comprises eeg glasses (electroencephalographic eyewear) with a side section of an eyewear frame which spans forward and upward onto a portion of the person's forehead and then curves back downward to connect to the front section of the eyewear frame. These eeg glasses (electroencephalographic eyewear) further include a flexible protrusion which is attached to the side section and an electromagnetic energy sensor which collects data concerning electromagnetic brain activity, wherein the flexible protrusion holds the electromagnetic energy sensor..
Medibotics Llc

Brain-computer interface for facilitating direct selection of multiple-choice answers and the identification of state changes

Methods, systems, apparatus, and non-transitory computer readable media are disclosed utilizing brain-computer interfaces (bcis). Various embodiments are disclosed to allow a user to directly select multiple-choice answers, to provide motorized wheelchair controls, and to allow a user to play a game via the bci.
The Regents Of The University Of Michigan

System and methods for neurological monitoring and assisted diagnosis

Methods and systems for assessing brain activity and collecting information related to a subject's condition and brain electrical activity are provided. The methods and systems include collecting and transferring data related to the neurological state of a subject.
Brainscope Company, Inc.

Content evaluation system and content evaluation method using the system

A reliable content evaluation method and system are disclosed. The system includes a brainwave detector, a bio signal detector, a first controller, and a second controller.
Nhn Entertainment Corporation

Linear velocity imaging tomography

The invention describes a new imaging modality based on linear velocity imaging tomography; its applications include differentiating between malignant and benign tissues, the ability to correlate an ecg trace with actual disorders of the heart and imaging brain communications.. .

Apparatus for detecting and providing brain signals by use of electroencephalography

Apparatus for monitoring a brain signal, especially indicative of muscle fatigue, comprises at least three sensors sensing neuronal activity, wherein one sensor (11) comprises a reference electrode and the other sensors (15, 16) comprise sensing electrodes, wherein the reference sensor (11) serves as a common reference for the other sensors (15, 16). The reference sensor (11) is placed within the quadrangle defined by the four positions [f5-f1-c 1-c5] or on a corridor of 10 millimetres width along the line between fpz to oz, the first sensing sensor is placed within the quadrangle [c1-c2-p2-p1], and the second sensing sensor is placed within the quadrangle [ft7-fc3-cp3-tp7], with the proviso that the reference electrode is not positioned on the same position as is one of the two sensing sensors and wherein the positions of the sensors delimiting the quadrangles are defined according to the 10-10 electrode placement system of the american clinical neurophysiology society..
Squipe Gmbh

Helmet extension connected to shoulder pad to prevent brain and spine injuries

A helmet supported by a vertical extension, extending from the rear-center of the helmet to the rear-center of shoulder pads or shoulder harness. The fixed in-place helmet is supported above the wearer's head, without relying upon the wearer for support, and permits the wearer to move his head in all directions.

System and enabling a user to improve on behavioral traits that are required for achieving success

A system for enabling a user to improve on behavioral traits that are required for achieving success is provided. The system includes an activity module, which enables the user to engage in activities in a virtual environment, wherein the activities affect wirings of the brain, whose symptom is at least one positive behavioral trait that is required for success.
Dharma Life Sciences Llc

Govbrain™ method, apparatus, and computer software

An apparatus for, computer software for, and automated method of predicting security price fluctuations comprising identifying potentially relevant news and government information relating to the security, parsing the potentially relevant news and government information, determining relevance of the potentially relevant news and government information to the security, and predicting a price move strength and direction for the security based upon relevance.. .
Govbrain Inc.

Single sensor brain wave monitor

In one example a data processing platform comprising circuitry to receive an input from a single electroencephalography (eeg) sensor and a single reference sensor, detect an increase in brain wave activity in a predetermined frequency range, and in response to the increase in brain wave activity in the predetermined frequency range, to generate an alert signal. Other examples may be described..
Intel Corporation

Methylated peptides derived from tau protein and their antibodies for diagnosis and therapy of alzheimer's disease

In sporadic alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of alzheimer's disease, which has remained elusive.
University Of Maryland, Baltimore

Monoclonal antibodies that specifically block biological activity of a tumor antigen

This invention relates to novel monoclonal antibodies that specifically bind to the alpha-folate receptor. In some embodiments, the antibodies inhibit a biological activity of folate receptor-α (fr-α).
Morphotek, Inc.

Immunological targeting of pathological tau proteins

The present invention relates to methods and compositions for treating, preventing, and diagnosing alzheimer's disease or other tauopathies in a subject by administering an immunogenic tau peptide or an antibody recognizing the immunogenic tau epitope under conditions effective to treat, prevent, or diagnose alzheimer's disease or other tauopathies. Also disclosed are methods of promoting clearance of aggregates from the brain of the subject and of slowing progression of tau-pathology related behavioral phenotype in a subject..
New York University

N-hydroxy bicyclic hydantoin carbamates as tools for indetification of serine hydrolase targets

Provided herein are n-hydroxy bicyclic hydantoin carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of serine hydrolases.
The Scripps Research Institute

Delivery of therapeutic compounds to the brain and other tissues

The present invention relates to the intrathecal (it) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-l-iduronidase (rhidu) injections in mps i affected animals resulted in significant enzyme uptake, significant rh-iduronidase activity in brain and meninges and a decrease of glycosaminoglycan (gag) storage in cells of mps i subjects to that of normal subjects.
Biomarin Pharmaceutical Inc.

Non-human mammal model of human degenerative disorder, uses thereof, and treating human degenerative disorder

The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels..
University Of Rochester

Non-human mammal model of human degenerative disorder, uses thereof, and treating human degenerative disorder

The present application relates to a non-human mammal model of a human neurodegenerative disorder, methods of producing the non-human mammal model, and methods of using the non-human mammal model to identify agents suitable for treating a neurodegenerative disorder. The present application also relates to methods of treating neurodegenerative disorders and restoring normal brain interstitial potassium levels..
University Of Rochester

Administration of a thiol-based chemoprotectant compound

A method of administration of a thiol-based chemoprotectant agent including nac (n-acetylcysteine) and sts (sodium thiosulfate) that markedly affects biodistribution and protects against injury from diagnostic or therapeutic intra-arterial procedures. A method for treating or mitigating the side effects of cytotoxic cancer therapy for tumors located in the head or neck and brain tumors.
Government Of The United States Of America, D/b/a The Department Of Veterans Affairs

Novel therapeutics for brain cancer

Provided herein are novel compositions and methods to inhibit olig2 activity. The olig2 inhibitors and methods of using the same are useful, inter alia, for treating cancer.
The Regents Of The University Of California

Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions

The present invention relates to the treatment of trauma haemorrhage or trauma haemorrhage-induced organ injury and associated disorders (in particular stoke, burns and brain injury) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the treatment of myocardial infarction and coronary heart disease (and associated disorders) using the anti-malarial compound artemisinin and its derivatives.
Queen Mary University Of London

A using haptic device and brain-computer interface for rehabilitation

A method for calibrating and executing a rehabilitation exercise for a stroke-affected limb of a stroke patient is disclosed, the method comprising the steps of providing a haptic device for an able limb of the stroke patient to manipulate to perform a calibration action to result in a first position of the haptic device, and providing the haptic device for the stroke-affected limb to manipulate to perform the calibration action to result in a second position of the haptic device. The method further comprises the steps of moving the haptic device coupled with the stroke-affected limb from the second position towards the first position until a predetermined counterforce is detected, indicating an extreme position for the stroke-affected limb using the haptic device, and calibrating the haptic device with the extreme position such that during the rehabilitation exercise, the haptic device is prevented from moving beyond the extreme position..
Agency For Science, Technology And Research

Set for applying a flat, flexible two-dimensional thin-film strip into living tissue

A set is provided for applying a flat, flexible two-dimensional thin-film strip into living tissue, particularly into brain tissue. The set includes the thin-film strip itself to be applied and an application tool, which is removable and mechanically connectable to the thin-film strip by a coupling device.
Ernst Strüngmann Institut Gemeinnützige Gmbh

Method and monitoring consciousness

Disclosed is a method of monitoring consciousness, the method including sensing at least two brainwave signals, extracting respective phase signals from the sensed brainwave signals, calculating entropy based on a variety in a change in terms of a phase difference between the extracted phase signals, and assessing a state of consciousness based on the calculated entropy.. .
Postech Academy-industry Foundation

Sensorimotor discs for infants and babies

In one example, we describe a method and system for infant's development, which is a disc system, with various combinations and extensions. The brain is the only organ that constantly reorganizes itself based on experiences or lack thereof.

Enhancements for voip communications

Voip telephone systems and methods are provided for use in a noisy listening environment. The systems and methods provide high quality voice broadcast into the noisy listening environment through independent voice channels which makes it easier for the human brain to discern broadcast words from the background noise..
Cloud9 Technologies, Llc

Simulating a target coverage for deep brain stimulation

F) determining, based on the patient image data and the atlas data and the electrode position data and the stimulation field data, target coverage data describing a coverage of the target anatomical structure by the electric stimulation field.. .

Repopulating failed replicas through modified consensus recovery

Using a quorum of fully updated replicas to designate a leader replica. A quorum of fully updated replicas designate a leader replica through “prepared” messages, allowing for restoration of failed replicas without a split-brain condition..
International Business Machines Corporation

Neurotoxicity biomarkers for diagnosis and treatment of acute traumatic brain and spinal cord injury

Provided herein are compositions, methods and kits for determining the level of an ampar/kar peptides in a subject. The methods include obtaining a biological sample from the subject and determining a level of one or more ampar/kar peptides selected from the group consisting of glur1/glur6_7, glur2/glur6_7, glur3/glur6_7, glur1/glur6, glur2/glur7, and any combination thereof in the biological sample..
Grace Laboratories, Llc

Composition and using mir-302 precursors as anti-cancer drugs for treating human lung cancer

This invention generally relates to a composition and method of using mam-made small rnas, such as small interfering rnas (sirna), micrornas (mirna) and their hairpin-like precursors (pre-mirna), as tumor suppressing anti-cancer drugs for treating human tumors and cancers, in particular, but not limited, for treating skin (melanoma), blood (leukemia), prostate, breast, liver and lung cancers as well as various neoplastic tumors, such as brain tumors and teratocarcinomas that contain a variety of tumorous and cancerous cells derived from all three germ layers of tissues, including ectoderm, mesoderm and endoderm. More specifically, the present invention relates to the use of mir-302-like sirna (sir-302) and/or mir-302 precursors (pre-mir-302) for developing novel medicines and therapies against a variety of human cancers, in particular lung cancers..

Blood-brain barrier shuttles containing antibodies recognizing alpha-synuclein

Alzheimer's and parkinson's disease comorbidity, and pure autonomic failure, as well as multiple system atrophy (msa).. .

Method and constructs for the ph dependent passage of the blood-brain-barrier

Herein is reported a fusion polypeptide comprising i) at least one binding site, e.g. Which comprises an antibody heavy chain variable domain and an antibody light chain variable domain, and which binds to an internalizing cell surface receptor, and ii) at least one pharmaceutically active compound, whereby the ec50-value of the binding pair that binds to an internalizing cell surface receptor determined at ph 5.5 is higher than the ec50-value of the same binding pair determined at ph 7.4 and its use for delivering a pharmaceutically active compound across the blood-brain-barrier..
Roche Glycart Ag

Kv2.1 channel-derived peptides and methods of use

Peptides capable of interfering with the kv2.1-mediated apoptotic k+ current surge that leads to neuronal cell death are described. The disclosed peptides are derived from the c-terminal region of kv2.1, which mediates binding to the snare protein syntaxin.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Use of fluorinated derivatives of 4-aminopyridine in therapeutics and medical imaging

The present disclosure provides novel compounds, including compounds that bind to potassium channels, methods for their manufacture, and methods for their use, including their use to diagnose and/or assess traumatic brain injury and use to treat dymeylinating diseases, and/or in vivo imaging of the central neverous system, and to diagnose and/or assess the progression of ms or other diseases.. .
The University Of Chicago

Organosulfur compounds for the prevention and treatment of neurodegenerative diseases

Organosulfur compounds and compositions are disclosed which can be administered in order to provide protection from the formation of aldehyde-protein adducts, protein aggregates, and the resulting neuroinflammation. Various neurodegenerative diseases which are suitable for treatment using these compositions include alzheimer's disease, senile dementia, parkinson's disease, multiple sclerosis, lewy body disease, peripheral neuropathy, spinal cord injury, traumatic brain injury, stroke and cerebral ischemia..

System and enabling a user to overcome depression

A method and system are provided for enabling a user to overcome depression. The method includes enabling the user to engage in a first activity and a second activity.
Dharma Life Sciences Llc

Mouth protector material

This uniquely constructed mouth protector material is designed to minimize damage and protection deficiencies associated with conventional athletic mouthpieces includes elastomer impregnated carbon fiber and resilient thermoplastics for encompassing the teeth. Each mouth protector material includes a thickness of elastomer infused carbon fiber overlain by and fused to pliable thermoplastics instantly disintegrating, deflecting and dissipating destructive forces directed to the head and mouth of a wearer so as to minimize damage.

Nanoparticle-mediated ablation of glioblastoma and of other malignancies

We disclose methods of treating cranial neoplasm using nanoparticles that are administered to the patient's brain. Our nanoparticles are novel, designed and synthesized explicitly to ensure their preferential accumulation in all parts of most brains that have remained with latent glioblastoma cells immediately after any primary neurosurgical debulking, and little or no accumulation in other parts of the brain..
Nanoprobes, Inc.

Device and use of photodynamic therapy

An apparatus including a light source provides for intracranial treatment of a tissue region of a brain of a patient. The intracranial treatment apparatus comprises an outer shaft having a proximal end and a distal end for positioning within the tissue region of the brain.

Efficient delivery of phototherapy using an optical light fiber

An apparatus for efficient delivery of light to a target site in a human body wherein the apparatus includes a light source and at least one stent having a lumen defined longitudinally therethrough. The light source is disposed longitudinally within the lumen of the stent and/or on a surface of the stent.
Depuy Synthes Products, Llc

Transcranial current stimulation (tcs) apparatus

Provided is a transcranial current stimulation apparatus. A transcranial current stimulation apparatus according to one embodiment of the present invention, which is put on or attached to the head of a user to apply an electrical stimulation to the brain, comprises: a first anode which comes into contact with a first part of the head and through which a first current flows; and a first cathode which comes into contact with a second part of the head and has a different amount of current from the first current..
Y-brain Inc.

Audio inducing brainwave using binaural beat

Disclosed herein are an audio apparatus and method for inducing a brainwave using a binaural beat, including a frequency shift unit for receiving a first audio sound source signal and generating a second audio sound source signal by shifting some of the frequency band of the first audio sound source signal by a specific frequency, and an audio output unit connected to the frequency shift unit, for outputting first and second audio output signals corresponding to the first and the second audio sound source signals. Accordingly, a user can hear a music signal or an audio signal for learning without being aware of the distortion of a sound source and can change his or her brainwave state without resistance or monotonousness because a required brainwave state is changed by applying a binaural beat to a specific frequency band of an audio signal, in particular, a music signal..
Dlogixs Co., Ltd

Selective dendrimer delivery to brain tumors

A composition comprising poly(amidoamine) (pamam) hydroxyl-terminated dendrimers covalently linked to at least one therapeutic, prophylactic or diagnostic agent for the treatment or alleviation of one or more symptoms of a brain tumor have been developed. The dendrimers comprise one or more ethylene diamine-core poly(amidoamine) (pamam) hydroxyl-terminated generation-4, 5, 6, 7, 8, 9, or 10, most preferably generation 6 (g4-10-oh) dendrimers.
The Johns Hopkins University

Amidated dopamine neuron stimulating peptides for cns dopaminergic upregulation

The present invention relates to novel proteins, referred to herein as amidated glial cell line-derived neurotrophic factor (gdnf) peptides (or “amidated dopamine neuron stimulating peptides (adns peptides)”), that are useful for treating brain diseases and injuries that result in dopaminergic deficiencies.. .
University Of Kentucky Research Foundation

Har-nds-derived stem cells, separating same, and use thereof

The present invention relates to hyaluronic acid-rich node and duct system (har-nds)-derived stem cells, a method for separating the same, and a use thereof and, more specifically, to node and ductal stem cells (ndscs), which are adult stem cells having an ability to differentiate into har-nds-derived neural cells, and hematopoietic stem cells having an ability to differentiate into blood cells. The present invention is capable of separating, from har-nds, adult stem cells ndscs and hematopoietic stem cells, which are not easy to obtain from bone marrow, peripheral blood and umbilical cord blood (cord blood), as an alternative source, and thus can be usefully used for treatment of brain diseases, neurological diseases, chronic infectious diseases, cancers, autoimmune diseases, organ regeneration treatments and various intractable diseases..
Eutilex Co., Ltd

General anesthetics that are not neurotoxic

The present application discloses the unexpected result that a neuroactive steroid such as b260 can act as a general anesthetic and that it has no neurotoxic side effects such as impairing brain development.. .

Method for performing stereotactic brain surgery using 3d geometric modeling

A method for performing a stereotactic brain surgery. The method includes first interposing a left and a right anthropological baselines on a patient's face, each trago-orbital anthropological baseline connecting an orbitale point and an auricular point on a corresponding side of the patient's face.

Method and system for brain activity signal-based treatment and/or control of user devices

A method for characterizing a brain electrical signal comprising forming a temporo-spectral decomposition of the signal to form a plurality of time resolved frequency signal values, associating each instance of the signal value with a predetermined function approximating a neurological signal to form a table of coefficients collectively representative of the brain electrical signal.. .
University Health Network

Sensor, system, and holder arrangement for biosignal activity measurement

The disclosure relates to a sensor, a system, and a holder arrangement for biosignal activity measurement. One example embodiment includes a sensor module for brain activity measurement.
Stichting Imec Nederland

Method for predicting convergence disorders caused by concussion or other neuropathology

A method for predicting abnormal eye convergence in a human or animal subject may involve tracking eye movement of at least one eye of the subject to generate eye tracking data for the subject and using the eye tracking data to predict whether the subject has abnormal eye convergence. A method for diagnosing a brain injury in a human or animal subject may involve tracking eye movement of at least one eye of the subject to generate eye tracking data for the subject, using the eye tracking data to predict whether the subject has abnormal eye convergence, and predicting whether a brain injury has occurred in the subject, based on the prediction of whether the subject has abnormal eye convergence..
Hennepin Healthcare System, Inc.

Electroencephalography (eeg) camera control

Various techniques for performing camera control techniques based on brainwave data from an electroencephalography (eeg) headset are disclosed herein. In an example, a computing system operates to receive brainwave data representing brainwave activity, process the brainwave data, and transmit a command to a camera device based on the processed brainwave data.
Intel Corporation

Methods, systems, and mediums for identifying changes to the brain profile of an individual

The invention relates to computer-based methods, systems, and mediums for identifying a change to the cumulative characterization of certain brain performance data collected from an individual, wherein the collected brain performance data is directly related to how at least one of the individual's neuromotor or cognitive brain functions is performing, hereinafter such a cumulative characterization is referred to as the individual's “brain performance profile”. The computer-based methods, systems, and mediums of the present invention identify and monitor changes in an individual's brain performance profile by employing a computer system which is programmed and configured to perform at least the following tasks: to compute an individual's normal brain performance profile through the implementation of a test session taken at least two separate times; to compute the individual's current brain performance profile through the implementation of the test session taken at a time after their normal brain performance profile has been computed; and, to calculate whether a change to the individual's brain performance profile has occurred through a mathematical manipulation of their normal brain performance profile and their current brain performance profile..
Board Of Regents, University Of Texas System

Headset with contactless electric field sensors for facial expression and cognitive state detection

A head-mounted display (hmd) device includes a plurality of activity detection sensors coupled to a liner formed around a periphery of a hmd or a band attached to the hmd. The sensors attached to the liner are adopted for direct or indirect contact to an upper portion of a user's face, and the sensors coupled to the band are adopted for direct or indirect contact with a back side of the user's head.
Oculus Vr, Llc

Hybrid reality based i-bot navigation and control

A system and method for interaction, navigation and control of an autonomous robot. The system comprises of two electronic devices, which are compatible with all operating systems and also compatible with magnetic trigger of a virtual reality device.
Tata Consultancy Services Limited

Methods for diagnosing and treating neuroimmune-based psychiatric disorders

The methods of the present invention are useful for determining whether an individual has or is at risk of developing a neuroimmune-based psychiatric disorder by detecting the expression level of one or more cytokine receptors in a biological sample. The methods of the present invention are also useful for the in vivo imaging of brain tissue by detecting one or more imaging agents such as ligands (e.g., cytokines) that bind to one or more cytokine receptors.
The Regents Of The University Of California

Method for opening tight junctions

The present invention is directed to a method and use of rna interference (rnai) for the transient, reversible and controlled opening of the tight junctions of the blood brain barrier and/or the blood retinal barrier. This method may be used in the treatment of many diseases and disorders which require the opening of the blood brain barrier and/or blood retinal barrier.
The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabe

Antibodies against the rgm a protein and uses thereof

The subject invention relates to isolated proteins, particularly monoclonal antibodies, which bind and neutralize rgm a protein. Specifically, these antibodies have the ability to inhibit the binding of rgm a to its receptor and/or coreceptors.
Abbvie Inc.

Pharmaceutical composition containing verbenone derivative for treating or preventing neurodegenerative disease

The present invention relates to a pharmaceutical composition or a functional health food comprising a verbenone derivative and pharmaceutically acceptable salts thereof as active ingredients for treating or preventing a neurodegenerative disease. More specifically, the verbenone derivative according to the present invention reduces neuronal cell death and oxidative stress, and is highly effective in preventing ischemic brain damage and inflammatory cell migration in rats, thereby providing the pharmaceutical composition or the functional health food which is useful in treating neurodegenerative diseases..
Korea University Research And Business Foundation

Method and system for controlling neural activity in the brain

A method and system for controlling neural activity in the brain, including performing a source localization procedure and a neurostimulation procedure, and using the former as a monitor to provide for feedback control of the latter.. .
Electrical Geodesics, Inc.

Novel synthesis of potential ester prodrugs

Esters prodrugs that cross the blood brain barrier can be ideal drugs for treatment of diseases of the central nervous system because the cerebral spinal fluid contains an abundance of esterases. The prodrug can be hydrolyzed into an active drug and a metabolite such as cholesterol that is known to be non-toxic and is familiar to the central nervous system.

Composition of lipid-based nanoparticles for small molecules and macromolecules

Described herein are nanoparticles comprising a mixture of a steroid, a phospholipid composition, an α-tocopheryl compound, and a therapeutic agent wherein the α-tocopheryl compound is presented on the surface of the nanoparticle. In some embodiments, the nanoparticles are useful for delivering a peptide or a protein.
University Of North Texas Health Science Center

Device for changing course of vessel and treatment method using the same

The present invention relates to a device for changing a course of a vessel, a method of introducing the device, a method of changing a course of a vessel using the device, and a treatment method of brain-nervous system diseases, such as neurovascular compression syndrome, using the device. In treating a neurovascular compression syndrome, the present invention can reduce risks and side effects of the microsurgery (mvd), such as hearing loss or facial paralysis that may occur due to the microsurgery.
University Of Pittsburgh -- Of The Commonwealth System Of Higher Education

Systems, devices and methods for resuscitation

Methods, devices, systems of resuscitating a patient including accessing an arterial vessel positioning a catheter into the arterial vessel advancing the catheter through the arterial vessel to position it below a vessel supplying blood to a heart and a brain expanding an expandable portion of the catheter to prevent blood from flowing past the expanded portion and infusing a substance retrograde into the artery within the arterial section between the bean and the expanded portion of the catheter.. .

Systems and methods to improve perfusion pressure during endovascular intervention

The invention relates to systems and methods to improve perfusion flow and pressure during endovascular intervention. In particular, the invention relates to catheters that enable both antegrade and retrograde flow through the catheter during a recanalization procedure and specifically at the step in a procedure where a clot is being withdrawn.

Image processing apparatus

An image processing apparatus according to an embodiment includes processing circuitry. The processing circuitry is configured to obtain three-dimensional image data of a brain acquired by performing a magnetic resonance imaging process.
Toshiba Medical Systems Corporation

System, method, and applications of using the fundamental code unit and brain language

The present invention relates to a non-invasive system with diagnostic and treatment capacities that use a unified code that is intrinsic to physiological brain function. In an embodiment of the present invention, an approach to the treatment of disorders that supplements existing diagnostic and treatment methods with robust quantitative data analysis are presented.

Electrode headset grid and use thereof in the non-invasive brain stimulation and monitoring

The present invention provides an electrode headset grid adapted to fit on a head of a human subject, the grid comprising a plurality of conductive regions, electrically isolated from each other, wherein the conductive regions are configured to contact at least one electrode, and wherein the configuration of the conductive regions is configured to define an operating electrode unit. There is further provided an integrated system for brain electric stimulation and eeg monitoring, the system comprising the electrode headset grid and a plurality of electrodes.
Nibs Neuroscience Technologies Ltd.

High definition eeg

A method, apparatus and system for measuring electrical activity generated within a brain is disclosed. A headpiece having a first transistor is placed in contact with a head that contains the brain to bring the first transistor into electrical contact with the head.
International Business Machines Corporation

System for a brain-computer interface

The invention provides a two-step approach to providing a bci system. In a first step the invention provides a low-power implantable platform for amplifying and filtering the extracellular recording, performing analogue to digital conversion (adc) and detecting action potentials in real-time, which is connected to a remote device capable of performing the processor-intensive tasks of feature extraction and spike classification, thus generating a plurality of predetermined templates for each neuron to be used in a second processing step.
Imperial Innovations Limited

Intraoperative guidance system for tumor surgery

The current invention pertains to a system and methods of identifying a site in a tissue of a patient as neoplastic or normal. The system comprises a source of electromagnetic signals; an optical probe which delivers the electromagnetic signals to a working end of the probe; a spectrometer which acquires diffuse reflectance electromagnetic signals returned from the site probed by the optical probe.
The Florida International University Board Of Trustees

Link aggregation split-brain detection and recovery

Various embodiments are described herein that provide a network system comprising a set of peers within a link aggregation group (lag), the first set of peers including a first network element and a second network element and a status resolution server to connect to the set of peers within the link aggregation group, wherein one or more peers within the lag is to query the status resolution server to determine an operational status of a peer in the set of peers in response to detection of an apparent failure of the peer.. .
Arista Networks, Inc.

Optogenetic magnetic resonance imaging

Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules.
The Board Of Trustees Of The Leland Stanford Junior University

Methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury

The present invention, in some embodiments, generally relates to methods of determining a treatment protocol for and/or a prognosis of a patient's recovery from a brain injury. In some embodiments, the brain injury results from a hypoxic event.
Quanterix Corporation

Myelination of congenitally dysmyelinated forebrains using oligodendrocyte progenitor cells

One form of the present invention is directed to a method of remyelinating demyelinated axons by treating the demyelinated axons with oligodendrocyte progenitor cells under conditions which permit remyelination of the axons. Another aspect of the present invention relates to a method of treating a subject having a condition mediated by a loss of myelin or a loss of oligodendrocytes by administering to the subject oligodendrocyte progenitor cells under conditions effective to treat the condition mediated by a loss of myelin or a loss of oligodendrocytes.
Cornell Research Foundation, Inc.

Kits for neural conversion of human embryonic stem cells

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction of neural plate development in hescs for obtaining midbrain dopamine (da) neurons, motorneurons, and sensory neurons.
Memorial Sloan- Kettering Cancer Center

Modulation of activity of neurotrophins

The present invention relates to methods for modulating the activity of one or more neurotrophins, such as neural growth factor (ngf), brain derived neurotrophic factor (bdnf), neurotrophin-3, and neurotrophin-4 (nt-4), in an animal and methods for treatment of a disease or disorder in an individual by modulation of neurotrophin activity. The modulation is carried out by interfering with binding between a neurotrophin and a receptor of the vps10p-domain receptor family or modulating the expression of a receptor of the vps10p-domain receptor family.
H. Lundbeck A/s

Apparatuses and methods for securing deep brain stimulation leads

Various examples are provided for securing deep brain stimulation (dbs) leads. In one example, among others, a dbs cap for securing a dbs lead includes a base ring adapted to be mounted within a counterbore opening formed in the skull, a lead securing element that mounts to the base ring, and.
University Of Florida Research Foundation, Inc.

Use of a neurofilament peptide for targeting neural stem cells

The present invention shows that the isolated nfl-tbs40-63 peptide is highly specific for neural stem cells. It is therefore presented here for use in a method for detecting these cells in vitro or in vivo, for addressing chemical compounds or biological materials to said cells, or for treating neurodegenerative disorders or brain tumours..
Lnstitut National De Ia Sante Et De Ia Recherche Medicale (inserm)

Compositions comprising unsaturated fatty acids and nitric oxide releasing compounds and use thereof for enhancing cognitive and related functions

Compositions include one or more unsaturated fatty acids and one or more nitric oxide releasing compounds. Methods for using such compositions can enhance cognitive function, reduce or prevent a decline of social interaction, reduce or prevent age-related behavioral changes, increase trainability, maintain optimal brain function, facilitate learning and memory, reduce memory loss, retard brain aging, prevent or treat strokes, and/or prevent or treat dementia in an animal.
Nestec S.a.

Method for treating, stabilizing or slowing down brain glucose metabolism deficit

The invention pertains to the use of (i) one or more of uridine and cytidine, or salts, phosphates, acyl derivatives or esters thereof, and (ii) a lipid fraction comprising at least one of docosahexaenoic acid (22:6; dha), eicosapentaenoic acid (20:5; epa) and docosapentaenoic acid (22:5; dpa), or esters thereof in the manufacture of a composition for use in a method for treating, stabilizing or slowing down brain glucose metabolism deficit in a subject in need thereof.. .
N.v. Nutricia

Anti-depression compounds

This technology relates generally to compounds and methods for stimulating neurogenesis (e.g., post-natal neurogenesis, including post-natal hippocampal and hypothalamic neurogenesis) and/or protecting neuronal cell from cell death. Various compounds are disclosed herein.
Board Of Regents Of The University Of Texas System

Maternal chelation for embryo, fetal and infant benefit

This invention teaches the use of chelating agents to diagnose and treat metal toxins in a patient. Chelation agents are given to the mother for the benefit of the baby.

Edible compositions and methods for promoting alpha brain waves

The present invention provides edible compositions, kits and methods for improving brain function/activity, the composition including at least one alpha brain wave promoting factor including theanine, and at least one neurotransmitter-precursor.. .

Ocular micro tremor (omt) sensor, system and method

An ocular micro tremor (omt) sensor, system and method for measuring micromovements of an individual's eyeball having an amplitude of 40 micrometers or less to provide a variable voltage biosignal for measuring the individual's brain stem activity. The omt sensor includes a flexible piezo-active sensing element mounted at the individual's closed or opened eyelid so as to be deflected by the micromovements of the eyeball.
Brainstem Biometrics, Inc.

Motor task detection using electrophysiological signals

Systems and methods are disclosed to detect and/or classify electrophysiological signals as motor events. In some embodiments, a method may include: recording a first plurality of electrophysiological signals from a first plurality of probes inserted into the left hemisphere of the brain; recording a second plurality of electrophysiological signals from a second plurality of probes inserted into the right hemisphere of the brain; pre-processing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; bipolar re-referencing the first plurality of electrophysiological signals and the second plurality of electrophysiological signals; determining an optimal pair of electrophysiological signals from the bipolar re-referenced first plurality of electrophysiological signals and the bipolar re-referenced second plurality of electrophysiological signals; matching the optimal pair of electrophysiological signals with a template; and detecting motor events from the matching..
Colorado Seminary, Which Owns And Operates The University Of Denver

Continuous monitoring of blood glucose production and ongoing targeting of blood glucose production via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.

Device for positioning the head of an animal and use thereof

A device, system, or method to aid in conducting brain activity analysis on an animal. The device may include a headrest for receiving at least part of the head of the animal, and a tube connected to the headrest for passing a treat to the animal through the tube so the animal is trained to position his or her head on the headrest and to maintain his or her head on the headrest for the time it takes to carry out the brain activity analysis.

Autostereoscopic pixel emitting unit and autostereoscopic display device

An autostereoscopic pixel emitting unit and multi-view autostereoscopic display device comprised of the pixel emitting units; an optical package covers the sub-pixel unit and each sub-pixel unit contains at least a red, green and blue light-emitting unit; each optical package contains at least an optical guide area and a mixing light area; the image display surface formed by matrix configuration can lead the multi-view stereoscopic images to left and right eyes of different viewers, and form stereoscopic vision through perception of human brains. The autostereoscopic display unit is minimized so that the display device has multiple advantages such as free from panel optical lens size restriction, large-area display, plane or curved surface installation, without frame joint, simultaneous display or functional conversion of 2d/3d images, easy maintenance, safety, and environmental protection..
Aladm 3d Display Technology Co., Ltd.

Methods and kits for detecting brain injury

The disclosure provides methods of detecting and monitoring brain injury in a test subject comprising analyzing a blood sample from the test subject for increased levels of prpc. The disclosure also provides kits for measuring the amount of prpc in a blood sample..
University Of Saskatchewan

Shaped coils for transcranial magnetic stimulation

Described herein are shaped coil tms electromagnets formed by two bent magnetic coil loops joined at a vertex having an angle between the outer coil regions of the coils that is typically less than 120 degrees (e.g., between about 45 and about 70 degrees, 60 degrees, etc.). The vertex region shaped to optimize the magnetic field projected from the tms electromagnet.

Skull-mounted deep brain stimulator

An implantable pulse generator (ipg) operable as a deep brain stimulator (dbs) is disclosed which is mountable to the skull of a dbs patient, and which therefore is much closer to the site of intended therapy. The ipg includes an electronics section, a charging coil section, a connector block section configured to connect to the proximal end of implanted leads, and an electrode wire section connecting the connector block section to the electronics section.
Boston Scientific Neuromodulation Corporation

Brain stimulation system including multiple stimulation modes

A system for treating a patient comprises a stimulator for stimulating brain tissue, a controller for setting stimulation parameters and a diagnostic tool for measuring patient parameters and producing diagnostic data. The stimulation parameters comprise test stimulation parameters and treatment stimulation parameters.
Functional Neuromodulation Inc.

A device and a providing resuscitation or suspended state in cardiac arrest

Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient. The device includes an electrically controllable redistribution component attachable to the patient to provide redistribution of the cardiac output to increase supply to the brain and heart.
Neurescue Aps

Infant nutrition for improving fatty acid composition of brain membranes

The present invention relates to infant nutrition, in particular to infant nutrition comprising special lipid globules for improvement of the fatty acid composition in brain membranes.. .
N.v. Nutricia

Methods, compositions and devices for treatment of motor and depression symptoms associated with parkinson's disease

Disclosed is a method of treating parkinson's disease and/or depression, and motor symptoms, non motor symptoms and depression symptoms associated with parkinson's disease in a subject in need thereof, the method including administering to said subject a pharmaceutical composition comprising rasagiline or a pharmaceutically acceptable salt thereof, wherein the administering is effected by intranasal administration, and wherein a daily dose of the rasagiline or pharmaceutically acceptable salt thereof in the pharmaceutical composition is sufficient to inhibit monoamine oxidase (mao)-a and mao-b in a brain but insufficient to inhibit systemic mao-a and therefore does not potentiate sympathetic cardiovascular activity associated with tyramine rich food consuming. Also, disclosed is a pharmaceutical composition including rasagiline or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier, and a device configured for intranasal administration of a pharmaceutical composition including rasagiline or a pharmaceutically acceptable salt thereof to a subject..
N To B Ltd.

Selective recruitment and activation of fiber types in nerves for the control of undesirable brain state changes

We disclose methods and medical device systems for selectively recruiting a nerve fiber type within a cranial nerve, a peripheral nerve or a spinal root. Such a method may comprise applying a first pressure, a heating, and/or a cooling to a second location of the nerve, the pressure, heating, or cooling sufficient to substantially block at least one of activation or conduction in at least one fiber population through the second location of the nerve for a blocking time period; and applying an electrical signal to a first location during the blocking time period..

Planning, navigation and simulation systems and methods for minimally invasive therapy

Disclosed herein are planning, navigation and simulation systems and methods for minimally invasive therapy in which the planning method and system uses patient specific pre-operative images. The planning system allows for multiple paths to be developed from the pre-operative images, and scores the paths depending on desired surgical outcome of the surgery and the navigation systems allow for minimally invasive port based surgical procedures, as well as craniotomies in the particular case of brain surgery..

Automatic segmentation and quantitative parameterization of brain tumors in mri

Techniques, systems, and devices are described for implementing automatic segmentation and quantitative parameterization of mri images. For example, the disclosed method includes processing the mri image to correct any distortions; performing a preliminary segmentation of the mri image to assign a tissue label of a set of tissue labels to one or more preliminary volumes of voxels of the mri image; comparing each voxel of the mri image with the one or more preliminary volumes of voxels with an assigned tissue label and assigning each voxel of the mri image a probability of being associated with each tissue label of the set of tissue labels; and assigning each voxel of the mri image a tissue label according to its greatest probability among probabilities for each voxel being associated with the set of tissue labels..

Reverse correlation of physiological outcomes

Embodiments of the present invention provide systems and methods for performing analysis validity ranking of information. The method utilizes technology such as mri, ct, pet, spect, eeg, and meg to collect a user's cognitive event, to analyze the user's cognitive event via analytics, and to correlate the user's cognitive event with a ranking.

Mri method to quantify iron amount in tissues using diffusion magnetic resonance imaging

A method to quantify and map iron deposits in the brain with diffusion-weighted magnetic resonance imaging (mri) is based on the differential sensitivity of mono-polar (mpg) gradient pulse diffusion sequences and bipolar (bpg) sequences on the local magnetic field gradients induced by iron deposits and their cross-term with the diffusion-encoding gradients. The method comprises the steps of acquiring (12, 14) first mri images and second mri of a region of interest by using mpg and bpg sequences, providing (16) an attenuation model of the diffusion mri attenuated signal representative of the observed tissue, estimating (18, 20) a first apparent diffusion coefficient adcmpg and a second apparent diffusion coefficient adcbpg by fitting the mri images with the attenuation model, calculating (22) a an iron induced local gradient factor ξfe as (formula i) (i), and determining (24) the concentration [fe] and/or the amount of iron stored in the local zone of the tissue from the calculated iron induced local gradient factor ξfe.

Protein biomarkers for acute, subacute and chronic traumatic injuries of the central nervous system

Proteins that are differentially expressed or elevated in tissue and biofluids after central nervous system injuries are described. Elevated or reduced levels of the proteins, alone or in various combinations or ratios, can be used to assess severity of central nervous system injury (cns injury) including traumatic brain injury (tbi), traumatic spinal cord injury (sci) and chronic traumatic encephalopathy (cte).

Signature of longitudinal gene expression changes to diagnose brain injury

Described herein are compositions and methods relating to biomarkers used to diagnose brain injury in a subject who has experienced a head trauma. The biomarkers described herein can be used to diagnose, monitor the onset, monitor the progression, and assess the recovery of brain injury.

Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease

The invention provides unique therapeutic and diagnostic antibodies, as well as their fragments, portions, derivatives, and variants thereof, that bind regions of the tau protein that contribute to the initiation and propagation of pathological tau-tau interactions, as well as methods of making them. The invention also relates to methods of using those antibodies for diagnostics, prevention, and treatment of alzheimer's disease and related tauopathies.

Peptide-mediated non-covalent delivery of active agents across the blood-brain barrier

The peptides described herein can function as carrier peptides. These peptides can associate with (e.g., non-covalently bind) biologically active molecules or imaging agents to transport the biologically active molecules or imaging across the blood-brain barrier.

Tetracycline derivatives with reduced antibiotic activity and neuroprotective benefits

The present disclosure is directed to compositions and methods which utilize the tetracycline scaffold, preferably the scaffold of tetracycline or minocycline, and which significantly lack antibiotic activity. The compounds have neuroprotective attributes without interfering with the drugs capacity to pass through the blood brain barrier.

Marmelin analogs and methods of use in cancer treatment

A pharmaceutical composition can include: a marmelin analog compound, and a pharmaceutically acceptable carrier having the compound. The compound can be present in a therapeutically effective amount to treat or inhibit a disease state.

Leadless neurostimulator

The present disclosure describes a medical device to provide neurostimulation therapy to a patient's brain. The device can be surgically implanted and can remain in the patient until end of life.

Cholinergic deep brain stimulator

A cholinergic deep brain stimulator is provided that can be used to increase brain acetylcholine levels. This increase in acetylcholine levels improves cognition and may be used to remediate disorders in which cognitive loss is a prominent symptom including alzheimer's disease, vascular dementia, traumatic brain injury, or drug addiction..

Systems and methods for determining a trajectory for a brain stimulation lead

Systems and methods for treating a cognitive disease or disorder are provided. A treatment method comprises: selecting a target volume of brain tissue to be stimulated; identifying at least one avoidance volume of brain tissue; selecting a first stimulation lead comprising at least one stimulation element; identifying at least one proposed trajectory for placement of the first stimulation lead based on the target volume and the at least one avoidance volume; placing the first stimulation lead along a placement trajectory selected from the at least one proposed trajectory; attaching the first stimulation lead to a stimulator; and stimulating the target volume with the first stimulation lead at least one stimulation element to treat at least one of a cognitive disease or a cognitive disorder.

Method, system and automated termination of a therapy for an epileptic event upon a determination of effects of a therapy

A method comprising detecting an epileptic event in a patient; applying an electrical therapy to a first target area in at least one of a brain region or a cranial nerve of said patient in response to said detecting; receiving a body signal responsive to the electrical therapy, wherein said body signal is selected from an autonomic signal, a neurologic signal, a metabolic signal, an endocrine signal, or a tissue stress marker signal; determining whether said body signal indicates that said electrical therapy has an efficacious effect; and terminating the application of said electrical therapy if the response indicates that the electrical therapy has an efficacious effect. An apparatus capable of performing the method.

Methods and systems for providing stimuli to the brain

Visual and auditory stimuli are provided to a patient to treat various neurological disorders or conditions and/or to provide improved mental or physical performance. The visual and auditory stimuli are provided by a wearable headset or sleep mask that may be comfortably worn by a user, such as in bed to induce sleep.

Systems and methods for preventing, mitigating, and/or treating dementia

The present disclosure provides systems and methods for at least one of preventing, reducing, and treating a level of or change in at least one of amyloid-β (aβ) peptide, c-terminal fragment-β (β-ctf), β-secretase (bace1), γ-secretase, neuroinflammation, and/or dementia (e.g., alzheimer's disease or age-related decline) in a subject by inducing synchronized gamma oscillations in the brain of the subject using, for example, a stimulus-emitting device to emit a stimulus (e.g., light, sound, and/or haptic) at a frequency (e.g., about 40 hz) that synchronously activates in vivo a specific cell type (e.g., fast-spiking-parvalbumin (fs-pv) immunoreactive interneurons) and/or brain region (e.g., a sensory cortex and/or hippocampus) of the subject.. .

Pharmaceutical formulations of nitrite and uses thereof

The present invention relates to pharmaceutical compositions of nitrites such as inorganic nitrites, or any pharmaceutically acceptable salts, solvates, or prodrugs thereof, and the medical use of these compositions. The pharmaceutical compositions, which can be formulated for oral administration, can provide immediate release or extended release of the nitrite ion (no2−).

Method and system for trackerless image guided soft tissue surgery and applications of same

Methods and systems for performing trackerless image guided soft tissue surgery. For a patient in need of brain surgery, pre-operative preparation for a patient is performed by generating a three-dimensional textured point cloud (tpc) for the patient's scalp surface, and registering the first three-dimensional tpc to a magnetic resonance (mr) model of the brain.

Methods and kits for repairing fractured bones and joints by chemical or biological agents

A method for repairing a fractured bone or a joint of a patient by chemical and/or biological agents, includes the steps of, determining an exact section of the fractured bone or the joint to be repaired, selectively delivering a quantity of an anesthetizing composition into skin surrounding the exact section in order for at least a portion of the anesthetizing composition to be absorbed by one or more tissues in vicinity of one or more nerves responsible for transmitting pain impulses from the exact section to brain of the patient in order to thereby selectively and remotely anesthetize at least a portion of the exact section, supervising the exact section in real-time and delivering one or more chemical and/or biological agents into the exact section, and, applying one or more bandages and/or one or more braces on the exact section for proper alignment and fusion.. .

Monitoring the body using microwaves

An apparatus for determining characteristics of pulsatility of the brain (5) comprises: an ultra-wideband microwave transceiver (1) arranged to generate ultra-wideband microwave pulses (6); a transmitting means (3) arranged to transmit the ultra-wideband microwave pulses; and a receiving means (3) arranged to receive a signal corresponding to detection of the pulses. A method of determining characteristics of pulsatility of a first part of the brain comprises: transmitting ultra-wideband microwave pulses into the first part of the brain; receiving a signal corresponding to detection of the pulses; and processing the signal..

Rehabilitation system and method

The present invention relates to a rehabilitation system (10) for a patient (24) suffering from a damaged muscle and/or nerve, said system (10) comprising: a brain activity sensor (14) for measuring a patient's brain activity related to controlling the damaged muscle and/or nerve; —a muscle sensor (18) for measuring a muscular activity of the damaged muscle and/or a neural activity of the damaged nerve; a display (22) for displaying a representation (34) of an affected body part of the patient (24); and a control unit (20) for determining an intended movement of the affected body part in which the damaged muscle and/or nerve is arranged, and for controlling the display (22) to display a representation (36) of the intended movement, wherein the control unit (20) is configured to determine the intended movement based on the patient's brain activity measured by the brain activity sensor (14) and based on the muscular and/or neural activity of the damaged muscle and/or nerve measured by the muscle sensor (18).. .

Eeg headsets with precise and consistent electrode positioning

This document discloses eeg headset designs that address shortcomings in prior art headsets and also provides headset solutions for new and useful applications utilizing eeg headsets. One such application is brain computer interface (bci) applications, and more specifically, a bci application for stroke therapy in which the headset is utilized to obtain ipsilateral brain signals.

Optical measurement system and optical brain function measurement method

This optical measurement system 100 is provided with a plurality of optical measurement units 1 and a control device 2 that controls the optical measurement unit. The control device includes a communication unit 24 that obtains specific state information 30 on whether or not the optical measurement unit is in a measurable state by communication for each of a plurality of optical measurement units, a display unit 25 that collectively displays the obtained state information for each of the plurality of optical measurement units, and a control unit 21 that controls a plurality of optical measurement units so that a simultaneous measurement is performed..

Apparatus and detecting lesion in brain magnetic resonance image, and computer-readable recording medium for implementing the method

Disclosed is an apparatus and method for detecting a brain lesion in a magnetic resonance (mr) image, and computer-readable recording medium for implementing the method. The apparatus includes an image area selector for receiving an mr image and creating an image of a brain portion (brain portion image) in which the brain portion is selectively presented; and an image processor for receiving the brain portion image and performing contrast adjustment on the brain portion image to obtain an image for diagnosis in which an area with a suspected lesion is emphasized..

System on chip (soc) based on neural processor or microprocessor

System on chips (socs) based a microprocessor or a neural processor (e.g., brain-inspired processor) electrically coupled with electronic memory devices and/or optically coupled with an optical memory device, along with embodiment(s) of building block (an element) of the microprocessor/neural processor, electronic memory device and optical memory device are disclosed. It should be noted that a microprocessor can be replaced by a graphical processor..

Method for segmenting and predicting tissue regions in patients with acute cerebral ischemia

A segmentation/prediction method is described for differentiating between infarct, penumbra and healthy regions in a tomographic (e.g. Mri or ct) image dataset of the brain of a stroke patient under examination.
UniversitÄt Bern

Preventing split-brain scenario in a high-availability cluster

As disclosed herein a method, executed by a computer, includes determining, by a processor, that a first node of a ha cluster is unable to communicate with a second node of the ha cluster, and initiating, by a processor, by the first node, a handshake operation with a connected client, wherein the handshake operation comprises requesting that the client determine a status of the second node and receiving, from the client, a response indicating the status of the second node. The method further includes accepting, by a processor, new requests in response to determining that the second node is unavailable, and requesting, by a processor, restoration of communications between the first node and the second node in response to determining that the second node is available.
International Business Machines Corporation

Indicia-reading systems having an interface with a user's nervous system

Indicia-reading systems that interface with a user's nervous system include a device with electrodes capable of detecting electromagnetic signals produced in the brain or skeletal muscles of a user. The systems also include a computer with a processor and memory.
Hand Held Products, Inc.

Use of epo-derived peptide fragments for the treatment of inflammatory diseases

The described invention provides compositions having epo-derived peptides, and methods and kits for administering the epo-derived peptide to a subject suffering from a neurodegenerative disease or an inflammatory disease of the brain or spinal cord. The epo-derived peptide delays the onset and/or progression of a neurodegenerative disease, limits cognitive impairment in, and prolongs the survival of, subjects suffering from a neurodegenerative disease or an inflammatory disease of the brain or spinal cord..

Method and providing transcranial magnetic stimulation (tms) to a patient

Wherein the number of magnet assemblies mounted on the head mount, their individual positioning on the head mount, and their selective provision of a rapidly changing magnetic field is selected so as to allow the spatial, strength and temporal characteristics of the magnetic field to be custom tailored for each patient, whereby to provide patient-specific tms therapy, to assist in diagnosis or to map out brain function in neuroscience research. In one preferred form of the invention, each of the magnet assemblies comprises a magnet for selectively providing a rapidly changing magnetic field of at least 500-600 tesla/second corresponding to a magnet movement speed of no less than 400 hertz..

Point-and-click programming for deep brain stimulation using real-time monopolar review trendlines

A system and method for selecting leadwire stimulation parameters includes a processor iteratively performing, for each of a plurality of values for a particular stimulation parameter, each value corresponding to a respective current field: (a) shifting the current field longitudinally and/or rotationally to a respective plurality of locations about the leadwire; and (b) for each of the respective plurality of locations, obtaining clinical effect information regarding a respective stimulation of the patient tissue produced by the respective current field at the respective location; and displaying a graph plotting the clinical effect information against values for the particular stimulation parameter and locations about the leadwire, and/or based on the obtained clinical effect information, identifying an optimal combination of a selected value for the particular stimulation parameter and selected location about the leadwire at which to perform a stimulation using the selected value.. .
Boston Scientific Neuromodulation Corporation

Method and preventing or terminating epileptic seizures

A method and apparatus for preventing or terminating seizures, by stimulating a brain with at least two implanted electrodes, each implanted in a different one of at least two regions of the brain, with a frequency to emulate and/or disrupt neuronal synchrony. Upon detecting a potential or actual seizure occurrence, the frequency is electrically applied to the brain upon the detection to preempt or terminate the potential or actual seizure occurrence..

Treatment of autoimmune diseases with deep brain stimulation

Techniques using electrical stimulation for treating an autoimmune disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation.
Aleva Neurotherapeutics

Method for treating neurotrauma

For use in the prevention or treatment of neurotrauma, traumatic brain injury, cerebral palsy and spinal cord injury.. .

Brainwave actuated apparatus

A brainwave actuated apparatus has a brainwave sensor for outputting a brainwave signal, an effector responsive to an input signal, and a controller operatively connected to an output of said brainwave sensor and a control input to said effector. The controller is adapted to determine characteristics of a brainwave signal output by said brainwave sensor and based on said characteristics, derive a control signal to output to said effector..
Interaxon Inc.

Non-invasive detection of spreading depolarization using scalp electroencephalography

Non-invasive electroencephalogram (eeg)-based methods for detecting a spreading depolarization secondary to a brain injury in a patient who exhibits high-amplitude delta activity in at least one channel of a scalp eeg of an injured brain hemisphere of the patient include (a) recording a baseline scalp eeg pattern in the patient at a channel exhibiting high amplitude delta activity; (b) recording a continuous scalp eeg pattern in the patient across a time frame at the at least one channel; and (c) detecting a spreading depolarization during the time frame by observing at least one feature indicative of a spreading depolarization in the continuous scalp eeg recording pattern relative to the baseline scalp eeg pattern at the at least one channel. Scalp eeg recordings are time-compressed prior to analysis.
University Of Cincinnati

Health assessment via eye movement biometrics

Methods and systems for assessing a health state of a person via eye movement-driven biometric systems are provided. Examples of the health states that it would be possible to detect with such a system are but not limited to brain injuries (e.g., concussions), dementia, parkinson's disease, post-traumatic stress syndrome, schizophrenia, fatigue, cybersickness, autism, bipolar disorder and other health conditions that manifest themselves in abnormal behavior of the human visual system.
Texas State University

Display device for practice of keyboard instrument diagramed with black keys as markers

In the present invention, images of a keyboard can be efficiently input into a learner's brain by using a display device in which two kinds of parallel black keys on a keyboard instrument are diagrammed as marker figures which are a substantially n-shaped figure and a substantially m-shaped figure, and the positions of pressed keys are plotted onto the marker figures. The display device can be configured using, for example, printed matter (e.g., a sheet or a card), a font set, an electronic display, and a three-dimensional object, and is provided as a sheet for writing music, performance or practice sheet music, learning cards, or a three-dimensional mimic keyboard.

System for identifying, associating, searching and presenting documents based on time sequentialization

The present invention discloses a system for identifying, associating, searching and presenting documents based on time sequentialization, which builds a computer-based knowledge management system for a professional field and improves the learning efficiency and utilization of professional field knowledge. The technical solution of the present invention includes finding a series of documents having an inter-document logical relationship with a group of specific keywords from massive documents in a keyword search manner, and naming a relation graph among the specific series of documents with a group of keywords strongly correlated therewith, and presenting the inter-document relation graph in time sequence in accordance with evolved versions; combining into one set a plurality of inter-document relation graphs of which the names have a group of like term keywords and which have specific logical relationships among one another, and naming the same with the group of like term keywords in a certain logic order.

Continuous monitoring of blood lactate and ongoing targeting of blood lactate via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides a deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.
Run Them Sweet Llc

Methods for neural conversion of human embryonic stem cells

The present invention relates generally to the field of cell biology of stem cells, more specifically the directed differentiation of pluripotent or multipotent stem cells, including human embryonic stem cells (hesc), somatic stem cells, and induced human pluripotent stem cells (hipsc) using novel culture conditions. Specifically, methods are provided for obtaining neural tissue, floor plate cells, and placode including induction of neural plate development in hescs for obtaining midbrain dopamine (da) neurons, motorneurons, and sensory neurons.
Memorial Sloan Kettering Cancer Center

Neuronal stimulator with micron resolution

An apparatus and method for stimulating one or more cells within a subject's brain by one or more magnetizable particles under the influence of at least one coil, wherein the coil is located outside the body of the subject, and is used to visualize and move the one or more magnetizable particles and to visualize the subject's underlying anatomy containing the one or more cells.. .
Weinberg Medical Physics, Inc.

2-phenylimidazo[1,2-a]pyrimidines as imaging agents

The compounds are suitable as imaging tool, which will improve diagnosis by identifying potential patients with excess of tau aggregates in the brain, which may be likely to develop alzheimer's disease.. .

Blood brain barrier shuttle

A blood brain barrier shuttle comprising a brain effector entity and a brain targeting peptide.. .
Hoffmann-la Roche Inc.

Methods of treating anorexia nervosa by intranasal administration of insulin

The present system is directed in several embodiments to a method of administration of a therapeutic composition for treatment of anorexia nervosa, safely and without significantly affecting the blood glucose or blood insulin levels of the patient. The method includes administering one or more therapeutic compositions comprising an effective amount of insulin directly to the subject patient's cns, with no to minimal systemic exposure.
Healthpartners Institute

Gcsf for use in the treatment of neurogenic immune suppression and/or prevention of related medical complications

The present invention relates to granulocyte colony-stimulating factor (gcsf) for use in the treatment of neurogenic immune depression syndrome, for use in the prevention of mortality after brain injury and for use in the prevention of brain inflammation after brain injury.. .
Fraunhofer-gesellschaft Zur Förderung Der Angewandten Forschung E.v.

Pluripotent stem cell for treatment of cerebral infarction

An object of the present invention is to provide a novel medical application to regenerative medicine that uses pluripotent stem cells (muse cells). The present invention provides a cell preparation for treating cerebral infarction and sequelae associated therewith that contains ssea-3-positive pluripotent stem cells isolated from mesenchymal tissue in the body or cultured mesenchymal cells.
Tohoku University

System and improved blood circulation and maintaining mitochondrial energy production

The disclosure relates to compositions, methods and systems for improving blood circulation and/or for the treatment of acute poor circulation of the liver, kidneys, heart, brain, and other organs utilizing highly concentrated tocotrienols/tocotrienol derivatives. The compositions, methods and systems of the disclosure may also be applicable in the treatment of chronic tissue hypoxemia, organ damage as a result of cell death, dementia, ulceration of the skin, and other such internal organ/brain/skin failure..

Threonate compounds and methods of use thereof

Provided herein is a method of using threonate to alter cellular physiology, such as neuronal physiology. A method of the present disclosure may include providing to a medium comprising a cell, a threonate-containing compound, or a precursor thereof, to increase the concentration of threonate in the medium, where the increased concentration of threonate is sufficient to increase the concentration of magnesium in the cell.
Neurocentria, Inc.

Apparatus for providing and maintaining access to a surgical site

The invention relates to an apparatus for providing and maintaining access to a surgical site, particularly a surgical site that needs to be accessed through delicate tissue such as brain tissue. The invention relates particularly to an apparatus that uses an expandable member or trochar.
Oxford University Innovation Limited

Method and device for functional imaging of the brain

Method for functional imaging of the brain, comprising the following steps: (a) a brain is imaged by ultrasound imaging in order to obtain a vascular image to be studied (ivo), (b) the vascular image to he studied (ivo) is compared automatically, by shape recognition, with a cerebral vascular atlas (av), and the vascular image to be studied (ivo) is thus located in the cerebral vascular atlas (av), (c) a cerebral functional atlas (af) corresponding to said cerebral vascular atlas (av) and comprising cerebral functional zones (1c) located in this cerebral vascular atlas (av) is used in such a way as to identify cerebral functional zones (1e) on the vascular image to be studied (ivo).. .
Universite Paris Diderot-paris

Imaging-based biomarker for characterizing the structure or function of human or animal brain tissue and related uses and methods

The invention relates to novel imaging-based biomarkers for characterizing the structure or function of a human or animal brain. These biomarkers can be a weighted confluency sum score (wcss) or a percent shielding by brain lesions (sbbl).
Jung Diagnostics Gmbh

Continuous diode laser stimulated raman gain/loss vibrational microscope

There is a need for a compact instrument and microscope that maps the vibration fingerprints of biomolecules and chemicals in a sample such as brain, breast, cervix, and arteries. One can use spontaneous raman scattering to accomplish this; however, the problem is low scattering efficiency to 10−5.

Differentiation of fluid volume change

A method for detecting evidence of a stroke in a patient may involve securing a volumetric integral phase-shift spectroscopy (vips) device to the patient's head, transmitting a first signal from a first transmitter of the vips device through a left hemisphere of the patient's brain to a receiver of the vips device, transmitting a second signal from a second transmitter of the vips device through a right hemisphere of the patient's brain to the receiver, and detecting the evidence of the stroke, with the vips device.. .
Cerebrotech Medical Systems, Inc.

Systems and methods to determine media effectiveness

Example systems and methods to determine media effectiveness are disclosed. An example system includes a synchronizer to time shift first neuro-response data gathered from an audience member exposed to media a first amount to align the first neuro-response data with second neuro-response data simultaneously gathered from the audience member to form aligned data, the first neuro-response data representing a first response to a first sensory component of the media and the second neuro-response data representing a second response to a second sensory component of media.
The Nielsen Company (us), Llc

Super cmos devices on a microelectronics system

This application is directed to a low cost ic solution that provides super cmos microelectronics macros. Hereinafter, scmos refers to super cmos and schottky cmos.
Schottky Lsi, Inc.

System and enabling a user to overcome anxiety

A method and system are provided for enabling a user to overcome anxiety. The method includes enabling the user to engage in a first activity, a second activity and a third activity.
Dharma Life Sciences Llc

System and enabling a user to overcome low self-esteem

A method and system are provided for enabling a user to overcome low self-esteem. The method includes enabling the user to engage in a first activity, a second activity and a third activity.
Dharma Life Sciences Llc

System and enabling a user to overcome weak behavioral traits

A system for enabling a user to overcome weak behavioral traits is provided. The system includes an activity module configured to enable the user to engage in at least a first and a second activity in a virtual environment.
Dharma Life Sciences Llc

Management apparatus, method, and computer readable medium

A computer implemented method includes reproducing first content activating a first site of a user brain, the first content being associated with a learning target item to be learned by the user, reproducing second content activating a second site of the user brain, the second content being associated with the learning target item, presenting a question about the learning target item after the first content and the second content are reproduced, and presenting a correct answer to the question.. .
Dancing Einstein Co., Ltd.

Failure logic modeling method for a high-speed railway train operation control on-board system

The present invention provides a failure logic modeling method for a high-speed railway train operation control on-board system, including the following steps: determining the functional relationship between the structure and the parts of the train control on-board system; analyzing the failures of the parts based on known failures of the train control on-board system in combination with brainstorming; establishing an fmea table to generalize the failures of the parts; editing and simulating the failures by using a modeling tool. By adopting the present invention, the failure modes analyzed are more systematic, and the failure logic modeling can be carried out from a global perspective more easily, the whole process can be better targeted meanwhile, the security analysis complexity of the train control system will be effectively reduced and the development period of the train control system will be shortened..
Beijing Jiaotong University

System for identifying, associating, searching and presenting documents based on relation combination

The present invention discloses a system for identifying, associating, searching and presenting documents based on relation combination, which builds a computer system-based knowledge management system in a professional field and improves the learning efficiency and utilization of professional knowledge. The technical solution includes finding a series of documents having an inter-document logical relationship with a group of specific keywords from massive documents in a keyword search manner, and naming a relation graph among the specific series of documents with a group of keywords strongly correlated therewith; combining, into one set, a plurality of inter-document relation graphs of which the names have a group of like term keywords and which have specific logical relationships among one another, and naming the same with the group of like term keywords in a certain logic order.

Brain-computer interface headset

Users of brain-computer interface (bci) systems wear an electroencephalography (eeg) headset that places multiple electrodes in contact with the scalp of the user. The eeg headsets provided herein provide user convenience and eeg accuracy.
Neurolutions, Inc.

Pharmaceutical use of fam19a5 involved in regulating gliogenesis

The present invention relates to the pharmaceutical use of fam19a5 involved in regulating gliogenesis, and more specifically, to the use of fam19a5 in the prevention, diagnosis, or treatment of central nervous system injuries, degenerative brain diseases, or central nervous system diseases, fam19a5 being spread in the neural stem cells in vertebrates and regulating gliogenesis.. .
Neuracle Science Co., Ltd.

Simulator system for different liquid flavors

The invention refers to a system for achieving the sensation of drinking a particular drink, known as the target, when in fact another drink, such as water, is being drunk. The invention consists of a glass which contains not only water but also a small amount of the target drink, in order to provide the true smell and image of the desired drink, as well as an electronic system for generating a series of signals which, by means of electrodes, stimulate the user's tongue, the effect of which is to act on a series of nerve cells, providing the brain with a signal as similar as possible to that which the real drink provides to the taste buds of the user.

Systems and methods for neuro-eeg synchronization therapy

Described are methods, devices, and systems for a novel, inexpensive, easy to use therapy for a number of disorders. Described are methods and devices to treat disorders that involves no medication.
Neosync, Inc.

Deep transcranial magnetic stimulation apparatus and method

A coil configuration and method for transcranial magnetic stimulation enabling stimulation of deep regions of the brain without excessively stimulating the cortex is provided. The coil configuration utilizes at least one coil to produce an off-plane magnetic field to enhance the magnetic field from a top tms coil.
Iowa State University Research Foundation, Inc.

Electrical substance clearance from the brain for treatment of alzheimer's disease

Apparatus is provided that includes a parenchymal electrode, configured to be implanted in brain parenchyma of a subject identified as at risk of or suffering from alzheimer's disease; and a ventricular electrode, configured to be implanted in a ventricular system of a brain of the subject. Control circuitry is configured to drive the parenchymal and the ventricular electrodes to clear a substance from the brain parenchyma into the ventricular system.
Rainbow Medical Ltd.

Programming adjustment for brain network treatment

The present invention involves methods and systems for treatment of brain disorders using neuromodulation of brain networks. Implantation occurs by selecting sites which modulate the network in selected manners, or are modulated by a stimulus in a particular manner that is relevant to treatment of the network.

Pyrrolo[2,3-c]pyridines as imaging agents for neurofibrillary

The present invention is directed to pyrrolopyridine compounds of formula (i) or their pharmaceutically acceptable salts, which may be suitable for imaging tau aggregates, b-sheet aggregates, beta-amyloid aggregates or alpha-synuclein aggregates, and hence are useful in binding and imaging tau aggregates in alzheimer's patients. More specifically, this invention relates to a method of using the compounds of this invention as tracers in positron emission tomography (pet) imaging to study tau deposits in brain in vivo to allow diagnosis of alzheimer's disease and other neurodegenerative diseases characterized by tau pathology.
Merck Sharp & Dohme Corp.

Method of making a liquid composition

Methods of making liquid compositions that can be used, for example, to improve human health, and in particular brain health are provided. The l-theanine is solubilized in water prior to the addition of other ingredients, such as acetyl-l-carnitine, choline bitartrate, inositol, n-acetyl l-tyrosine and pyrroloquinoline quinone (pqq).
Braingear Enterprises, Inc.

Method for treating cognitive impairment associated with neurodegenerative disorders

A method for treating alzheimer's disease (ad) by administering an efficacious amount of artemisone. It is hypothesized that the treatment counters ad by inhibiting the production of the amyloid protein which has been implicated as a contributing factor to the onset of ad and the associated ad dementia and memory loss.

Medicament for preventing and/or treating stress diseases

The present invention relates to a medicament for preventing and/or treating stress diseases, said medicament being characterized in that (1s)-2-acetyl-1-(4-chloro-2-methoxyphenyl)-5-fluoro-1,2,3,9-tetrahydrospiro[β-carboline-4,1′-cyclopropane] is administered at such a specific dose that a brain tspo occupancy requiring for expressing the pharmacological effects of the medicament can be obtained.. .
Ono Pharmaceutical Co., Ltd.

Compounds and pharmaceutical combinations for the treatment of neurodegenerative and ischemic brain diseases

The present invention describes peptides comprising phycocyanobilin (pcb), as well as the medical use of said peptides and that of pcb, due to the neuroprotector and/or neuroregenerative effects identified for them. Furthermore, pharmaceutical combinations of said peptides and of pcb with proteins or other peptides with synergic effect justify their use for ischemic or neurodegenerative cns disease treatment..
Centro De Ingenieria Genetica Y Biotecnologia

Vibratory massage device

Implementations of a vibratory massage device used for the treatment and/or relief of pain are provided. In some implementations, the vibratory massage device may comprise a flexible band having three vibration motors enclosed within individual housings and two power sources secured thereon, a switch for selectively energizing the vibration motors, and a removable sleeve.

Recessed burr hole covers and methods for using the same

A burr hole cover is configured to be recessed in a burr hole formed in a patient and includes a base and a cap provided with complementary features to allow a portion of a medical device, such as a brain lead, to be situated in the burr hole cover and then secured by rotation of the cap relative to the base. The features include channels on the base and matching cut-outs on the cap, and slots and locking pockets on the base that are configured to be aligned with locking tabs and locking protrusions on the cap.
Neuropace, Inc.

Thermoablation probe

A thermoablation probe for performing an interstitial thermal therapy (itt) procedure on a brain lesion generally includes a rigid sheath and a flexible treatment device telescopically slidable within the sheath. The treatment device has a substantially continuous covering and a shape-memory wire enveloped by the covering..
Board Of Trustees Of Southern Illinois University

Brain-controlled body movement assistance devices and methods

Methods, devices, systems, and apparatus, including computer programs encoded on a computer storage medium, for brain-controlled body movement assistance devices. In one aspect, a device includes a brain-controlled body movement assistance device with a brain-computer interface (bci) component adapted to be mounted to a user, a body movement assistance component operably connected to the bci component and adapted to be worn by the user, and a feedback mechanism provided in connection with at least one of the bci component and the body movement assistance component, the feedback mechanism being configured to output information relating to a usage session of the brain-controlled body movement assistance device..
Neurolutions, Inc.

System and electric brain stimulator

The invention provides a method for electric brain stimulator. In the beginning, obtaining a brain functional amplitude modulation spectrum, wherein the brain functional amplitude modulation spectrum is a relationship between carrier frequency and amplitude-frequency on different brain sites.
National Central University





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