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 Apparatus and  brain training patent thumbnailApparatus and brain training
An apparatus and method for brain training, including at least one first vibratory stimulation unit configured to generate vibratory stimuli with the user's skull; at least one second vibratory stimulation unit configured to generate vibratory stimuli with the user's body movement senses; at least one brain wave detecting unit configured to detect the brain wave of the user; and a controlling unit configured to connect with and control the visual stimulation unit, the first vibratory stimulation unit, the second vibratory stimulation unit and the brain wave detecting unit. By using the apparatus, the user can trigger active different parts area of brain to respond to the stimulations in a non-invasive way to improve the metabolism of brain tissue and help the neurons-to-neurons communication, which would be used in different occasions to improve the learning ability of users..

 Cluster mapping based on measured neural activity and physiological data patent thumbnailCluster mapping based on measured neural activity and physiological data
Techniques are described for determining recommended tourist based on the real time collection and analysis of biological information regarding users. Sensors in proximity to a user may collect neural activity data (e.g., brain wave data) and physiological data (e.g., blood pressure, heart rate, blood sugar level, etc.).
Accenture Global Services Limited


 Apparatus and  implantable bidirectional wireless neural recording and stimulation patent thumbnailApparatus and implantable bidirectional wireless neural recording and stimulation
A device and method is described for electronic human prosthetics, and specifically a skull- and/or spine implantable bi-directional neural-communication/brain-machine interface (bbmi) device where the input, output and on-board computing are combined into a single unit to form a compact neuro-prosthetics device. This invention is also directed to a fully implantable wireless spinal electronic recording and stimulation system using the bbmi in a human.
The San Diego University Research Foundation


 Methods of modulating inflammasome activity to treat inflammatory conditions patent thumbnailMethods of modulating inflammasome activity to treat inflammatory conditions
Compositions and methods for reducing inflammation in the central nervous system (cns) of a mammal that has been subjected to a stroke, traumatic injury to the cns such as traumatic brain injury (tbi), spinal cord injury (sci), or having an autoimmune or cns disease have been developed. The compositions and methods described herein include antibodies that specifically bind to at least one component (e.g., asc, nalp1) in a mammalian inflammasome (e.g., the nalp1 inflammasome) and have use as treatments for sci, tbi, stroke, and autoimmune and cns diseases in a mammal.
University Of Miami


 Neuroprotective composition and  use patent thumbnailNeuroprotective composition and use
A therapeutic composition for treating brain injury comprising a polyarginine peptide of from 5 to 9 arginines, and further comprising 1 or more terminal cysteines. The composition is administered in therapeutically effective dosages prophylactically or as soon as possible post-injury in treating neuronal injury..
Wayne State University


 Control of spike-timing dependent brain network plasticity via multi-coil transcranial magnetic stimulation patent thumbnailControl of spike-timing dependent brain network plasticity via multi-coil transcranial magnetic stimulation
brain stimulation methods and devices in which at least two separate magnetic pulse sources with interposed space between them are placed over two distinct brain regions. The coils are pulsed at between 1 and 100 milliseconds apart (e.g., between 5 ms and 40 ms), thereby producing neuroplastic effects upon a third brain region that is network-connected to said first and second regions..
Rio Grande Neuroscences, Inc.


 Frequency stimulator patent thumbnailFrequency stimulator
In some cases, a frequency stimulator that can control a dosage of impulses of various low frequencies of electromagnetic waves, uses a cell phone, a tablet, a laptop, and/or any other suitable devices that produce frequencies and can supply an inductive coil that is installed in a headband of the frequency stimulator in a way to produce a low frequency electromagnetic field with the basic purpose of achieving a positive response to the frequency of the human brain that responds to a programed frequency and adjusts to it, thus creating various states of consciousness in the human head. In some cases, the power source is connected to the headband in which there is the induction coil.

 Humanized anti-tau(ps422) antibody brain shuttles and use thereof patent thumbnailHumanized anti-tau(ps422) antibody brain shuttles and use thereof
Herein is reported a non-covalent complex of a haptenylated antibody that specifically binds to human tau(ps422) and an anti-blood brain barrier receptor/hapten bispecific antibody.. .
Hoffmann-la Roche Inc.


 Methods of treating traumatic brain injury and sequelae patent thumbnailMethods of treating traumatic brain injury and sequelae
Methods and compositions are presented for treating traumatic brain injury and complications of traumatic brain injury, including pulmonary complications and cerebral edema.. .
Cantex Pharmaceuticals, Inc.


 Osmotic enhancement of drug/therapeutic delivery to the brain following infusion or injection into the cerebrospinal fluid patent thumbnailOsmotic enhancement of drug/therapeutic delivery to the brain following infusion or injection into the cerebrospinal fluid
A method of enhancing therapeutic/drug transport to the perivascular space of the brain of a patient is disclosed. In one embodiment, the method comprises the step of introducing a therapeutic/drug and an osmolyte of the present invention into a patient's cerebrospinal fluid (csf), wherein the osmolyte is introduced to the csf at a concentration of between 0.5 and 12.9 m (dependent on the solubility upper limit of the osmolyte), and wherein the therapeutic/drug delivery to the perivascular spaces of cerebral blood vessels and parenchyma of the central nervous system is facilitated by the presence of the osmolyte..
Wisconsin Alumni Research Foundation


Assembly, esophagus catheter and controlling a temperature of at least a part of a person, in particular the brain of the person

The present invention relates to an assembly for controlling a temperature of at least a part of a person, comprising an esophagus catheter to be inserted into the esophagus of the person for controlling the temperature. The esophagus catheter extends along a longitudinal axis and comprises a proximal heat exchanger defining a first flow direction having a first axial component relative to the longitudinal axis, and a distal heat exchanger defining a second flow direction having a second axial component relative to the longitudinal axis.
Gelanus B.v.

Method and system for assessing learning experience of a person

A method and system is provided for assessing the learning experience of the person by monitoring the mental state of the person. The method involves measuring the brain signal, skin conductance using gsr device, and heart rate variability using the pulse oximeter.
Tata Consultancy Services Limited

Systems and methods for programming and operating deep brain stimulation arrays

Systems, methods and apparatus for determining and/or programming stimulation settings for a pulse generator capable of steering current to a deep brain stimulation array are disclosed. Individual patient brain geometry and lead specific geometry data can be used to generate a maximum activation function curve.
Regents Of The University Of Minnesota

Methods and associated neural prosthetic devices for bridging brain areas to improve function

Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites.
Case Western Reserve University

Receptor imaging systems and related methods

A method includes administering to a subject (i) a pharmacological agent that binds to receptors in a subject, and (ii) a radiotracer to alter a functional state and occupancy of the receptors in the subject. The method also includes acquiring imaging data of brain tissue in the subject comprising the receptors.
The General Hospital Corporation

Treatment of glioma by anti-angiogenic active immunization for direct tumor inhibition and augmentation of chemotherapy, immunotherapy and radiotherapy efficacy

Disclosed are compositions of matter, therapeutic protocols, and immunization means to induce an active immune response to vasculature feeding glioma or other brain neoplasia. In one embodiment the invention provides administration of placental derived endothelial cells at concentrations of 10 million to 50 million administered in a manner to stimulate immunity toward blood vessels supplying glioma or other brain neoplastic malignancies.
Batu Biologics, Inc.

Multimodal transcranial brain optical imaging

A method of transcranial brain optical imaging including obtaining a laser speckle (ls) image of cranial blood vessels of a subject, obtaining a dynamic fluorescence (df) image of the cranial blood vessels of the subject, and combining the ls image and the df image producing a combined color image which displays both structure of the cranial blood vessels and perfusion of blood along the cranial blood vessels. Related apparatus and methods are also described..
Ministry Of Health On Behalf Of The Jerusalem Mental Health Center

Compositions and methods for analyzing collateral density

The present invention provides a retinal predictor index (rpi), composed of discrete geometric and fractal descriptors of the branch-patterning of the outer retinal circulation, as a biomarker for differences in the extent (number and diameter) of collateral blood vessels in brain, heart, lower extremities and other tissues.. .
The University Of North Carolina At Chapel Hill

Devices and methods for providing focal cooling to the brain and spinal cord

Systems and methods for systems and methods for focal cooling of the brain and spinal cord are disclosed. Some embodiments may be directed to a neuroprotection system that includes a cerebrospinal fluid processing platform.
Minnetronix, Inc.

Cell structure for brain damage treatment, production method thereof, and brain damage treatment agent

An object of the present invention is to provide a cell structure for brain damage treatment which does not contain glutaraldehyde and in which it is possible to exhibit a sufficient effect of treating brain damage, a production method thereof, and a brain damage treatment agent. According to the present invention, there is provided a cell structure for brain damage treatment which contains biocompatible macromolecular blocks and at least one kind of cell and in which a plurality of the biocompatible macromolecular blocks are disposed in gaps between a plurality of the cells, in which the tap density of the biocompatible macromolecular block is 10 mg/cm3 to 500 mg/cm3 or a value obtained by dividing a square root of a cross-sectional area in a two-dimensional cross-sectional image of the biocompatible macromolecular block by a peripheral length is 0.01 to 0.13..
Fujifilm Corporation

Galactoside inhibitors for new uses

Provided is a method for treatment or prevention of α-synucleinopathies in a mammalian subject, the method comprising administering a therapeutically effective amount of at least one composition to the subject, wherein the composition comprises a molecule for pharmacological modulation of galectin activity in a mammalian brain.. .
Galecto Biotech Ab

Intelligent wheel chair control method based on brain computer interface and automatic driving technology

Pid path tracking algorithm; and calculating a reference angular velocity and linear velocity by means of the pid path tracking algorithm and transmitting them to a pid motion controller, converting odometry data from encoders into current angular and linear velocities as a feedback of the pid motion controller, and controlling the driving of the wheel chair in real time to the destination. The intelligent wheel chair control method greatly relieves the mental burden of a user, can adapt to changes in the environment, and improves the self-care ability of patients with severe paralysis..

Apparatus and measuring biologic parameters

Support structures for positioning sensors on a physiologic tunnel for measuring physical, chemical and biological parameters of the body and to produce an action according to the measured value of the parameters. The support structure includes a sensor fitted on the support structures using a special geometry for acquiring continuous and undisturbed data on the physiology of the body.
Geelux Holdings, Ltd.

Biological brain age calculation device and calculation method therefor

A biological brain age is calculated by measuring a brain cortex thickness of each region in a brain mri image of a person to be examined, and comparing the measured brain cortex thickness with normal control group information. A device for calculating the biological brain includes an image information input unit to input an mri brain image of a person to be examined, a brain age calculation control unit to control a biological brain age calculation operation of the person to be examined based on the mri brain image, a brain thickness measuring unit to measure a brain cortex thickness of each region in the mri brain image, and a brain age calculating unit to match the measured brain cortex thickness with a normal range of brain thickness of each age, and calculate a biological brain age of the person to be examined..
Industry-academic Cooperation Foundation, Yonsei University

Signal processing methods

We describe a method of processing an eeg and/or meg signal to generate image data representing a 3d current distribution, j, within the brain, the method comprising: capturing a plurality of electric and/or magnetic measurements from the exterior of the head; solving an integral equation for a part of said current distribution to generate said image data representing said 3d current distribution, wherein said integral equation comprises an integral of a first function representing said part of said current distribution and of a second function (∇τvs (r, τ)) representing the geometry and conductivity of the head independent of said current distribution; wherein said solving comprises: modelling the head as at least two regions separated by at least one internal boundary, and solving a set of partial differential equations, one for each said internal region, each partial differential equation comprising a geometry-conductivity function (w(r, τ)) representing the geometry and conductivity of the respective region, wherein said solving is subject to a boundary condition that either i) the gradients of the functions across the or each said internal boundary are smooth when conductivity is taken into account, or ii) a normal component of the electric field of said part of said current distribution is continuous across the or each said internal boundary, and wherein said geometry-conductivity function for an outermost said region of said head defines said second function (∇tvs (r, τ)). .
Cambridge Enterprise Limited

Preventing data corruption due to pre-existing split brain

Various methods, systems, and processes to prevent data corruption caused by a pre-existing split brain condition in a cluster are presented. In response to determining that a node is no longer part of a sub-cluster, another node in the sub-cluster is designated as a racer node.
Symantec Corporation

Methods and devices for providing enhanced visual acuity

The specification describes an enhanced reality visual interface in the form of smart eyeglasses that view, process, and project desired visual information to a user's field of view. High resolution picture elements or super-pixels are used to create an enhanced image for a user, based on the user's actual visual acuity and the desired enhanced image.
Supereye, Inc.

Product identification using electroencephalography

An eeg pos system has an eeg device that detects electrical signals representing brain waves. A database of brain wave profiles represents a plurality of items to be identified.
Hand Held Products, Inc.

Treatment of neurotrauma using antibodies to lysophosphatidic acid

Methods are provided for treating neurotrauma, for example, traumatic brain injury (tbi), using antibodies and antibody fragments that bind lysophosphatidic acid (lpa). Such treatment may result in functional locomotor recovery in subjects so treated, as well as reducing the size of a brain infarct in subjects having or suspected of having sustained neurotrauma such a tbi..

Nanoparticle compositions and methods of making and using the same

Water soluble graphene oxide nanoparticles (go) are provided having graphene sheets containing carboxylic and hydroxyl groups. The diameter of the go when present in a closed form ranges from about 40 nm to 120 nm.
Cromoz, Inc.

Transnasal delivery of low level light via the sphenoidal sinus to irradiate the substantia nigra

A transnasal delivery method for treating or preventing parkinson's disease using photobiomodulation. An optical system is provided including a light source and an optical fiber.
Depuy Synthes Products, Llc

System for variably configurable, adaptable electrode arrays and effectuating software

Electrical non-invasive brain stimulation (nibs) delivers weak electrical currents to the brain via electrodes that are affixed to the scalp. Nibs can excite or inhibit the brain in areas that are impacted by that electrical current during and for a short time following stimulation.
Rio Grande Neurosciences, Inc.

Life maintenance mode, a brain inhibition therapy and a personal health information platform

A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advices and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming service.. .

Engineering synthethic brain penetrating gene vectors

A synthetic gene delivery platform with a dense surface coating of hydrophilic and neutrally charged peg, capable of rapid diffusion and widespread distribution in brain tissue, and highly effective gene delivery to target cells therein has been developed. Nanoparticles including nucleic acids, are formed of a blend of biocompatible hydrophilic cationic polymers and they hydrophilic cationic polymer conjugated to hydrophilic neutrally charged polymers such as polyethylene glycol.
The Johns Hopkins University

Gene therapy for neurodegenerative disorders

Compositions and methods for treating disorders affecting motor function, such as motor function affected by disease or injury to the brain and/or spinal cord, are disclosed.. .
Genzyme Corporation

Composition for treating inflammatory brain disease comprising stem cell-derived exosome as an active ingredient

The present invention relates to a composition for treating inflammatory brain diseases, which includes stem cell-derived exosomes as an active ingredient. The stem cell-derived exosomes according to the present invention can be usefully applied to the treatment of inflammatory brain diseases, because the exosomes have outstanding therapeutic effects, including inhibiting cell death due to inflammation in nerve cells, increasing the survival rate in an inflammatory-brain-disease animal model, and substantially reducing brain damage and inflammatory cytokine levels due to inflammatory reactions such as edema..
Samsung Life Public Welfare Foundation

Bone-conductive arousal induction apparatus

The present invention provides an apparatus and methods to deliver audible acoustic sound to the brain through bone conduction and to terminate snoring and sleep apnea. The apparatus comprises a control module and a device that measures signs of the snoring and the sleep apnea and generates the audible acoustic sound to arouse a subject.

Life maintenance mode, a brain inhibition therapy and a personal health information platform

A life maintenance mode named as the third type of life maintenance mode, includes decomposing inspection items of clinical diagnosis into a series of individual automatically measured and computed indicators of life condition data, popularized into people's daily life and work to be practiced continuously producing continuous diagnosis and inspection analysis report and trend; performing active control of the change of the life condition data by senior independent consciousness of cerebral cortex with the automatically measured and computed life condition data to serve as a quantitative traction device for treatment, rehabilitation, and health and longevity; predict and prevent the occurrence and development of diseases on the basis of the produced inspection analysis report and trend; automatically sending messages to remind a patient to check the treatment behaviors on the basis of doctor's advices and prescriptions in the track record of medical treatment, and providing an automatic no-response alarming service.. .

Formulas comprising optimised amino acid profiles

The present invention relates to infant formulas and follow-on formulas containing optimised amino acid profiles, in particular optimised amounts and/or ratios of phenylalanine. The formulas may contain intact proteins, hydrolysed proteins, protein fractions, free amino acids and/or a combination thereof selected based on their ability to provide the formula with an optimised amino acid profile.
N.v. Nutricia

Storing, indexing and recalling data based on brain activity

In a method for storing and recalling stored data, data to be stored is received and a first brain activity information from a user is received. The first brain activity is hashed to generate a first brain activity information hash value.
International Business Machines Corporation

Stereo 3d head mounted display applied as a low vision aid

Embodiments of this invention generally relate to three dimensional head mounted displays (hmd) with stereo cameras that could be used as a vision platform for applications that modify the camera images to benefit people who suffer from eye diseases, brain trauma, and brain diseases. Embodiments take images from stereo cameras that are integrated into a head mounted display.
D.r.i. Systems Llc





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