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Brain

Brain-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Impact-driven traumatic brain injury testing apparatus
February 15, 2018 - N°20180047305

The present invention provides an apparatus and methods to quantitatively measure a physical perturbation to a human head model by a mechanical impact of a blunt trauma. The apparatus is configured to obtain a set of non-contact measurement data from the human head model upon the mechanical impact. A source of the mechanical impact is configured to vary in kinetic ...
Biguanide compound and use thereof
Immunomet Therapeutics Inc.
February 15, 2018 - N°20180044283

The present invention relates to a guanidine compound and a use thereof, and more specifically, to a guanidine derivative showing excellent effects of inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence; a preparation method thereof; and a pharmaceutical composition containing the same as an active ingredient. Compared to existing drugs, the guanidine derivative according to the present invention shows ...
Bacterially derived, intact minicells for delivery of therapeutic agents to brain tumors
Engeneic Molecular Delivery Pty Ltd
February 15, 2018 - N°20180043027

Systemic administration of intact, bacterially derived minicells results in rapid accumulation of the minicells in the microenvironment of a brain tumor, in therapeutically significant concentrations, without requiring endothelial endocytosis/transcytosis across the blood brain barrier or any other mechanism by which, pursuant to conventional approaches, nanoparticles have entered into that microenvironment. Accordingly, a wide variety of brain tumors, both primary ...
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Human cord blood as a source of neural tissue repair of the brain and spinal ...
Saneron Ccel Therapeutics, Inc.
February 15, 2018 - N°20180042968

The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to ...
Phosphodiesterase inhibitors to repair brain and/or retinal injury in human newborns
February 15, 2018 - N°20180042927

The present disclosure concerns the use of a phosphodiesterase inhibitor, such as, for example, sildenafil, to repair a brain and/or a retinal injury in a newborn. The phosphodiesterase inhibitor can be used in a premature or a term baby that has been exposed to hyperoxia or hypoxia which caused a brain and/or a retinal injury.
Method of treating a brain tumor
Beyondspring Pharmaceuticals, Inc.
February 15, 2018 - N°20180042921

Disclosed herein are methods of treating a brain tumor by administering plinabulin. Some embodiments relate to treatment of glioblastoma multiforme by administering plinabulin.
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Wireless wearable brain blood-oxygen monitoring system
Institute Of Automation Chinese Academy Of Sciences
February 15, 2018 - N°20180042537

The wireless wearable brain blood-oxygen monitoring system provided by the present application comprises a monitoring control device, a detection device, a fixing device and a flexible printed circuit board; said monitoring control device is used for processing a first optical signal to generate a digital signal and sending said digital signal to a portable mobile terminal; said detection device is ...
Intraoperative guidance system for tumor surgery
The Florida International University Board Of Trustees
February 15, 2018 - N°20180042485

The current invention pertains to a system and methods of identifying a site in a tissue of a patient as neoplastic or normal. The system comprises a source of electromagnetic signals; an optical probe which delivers the electromagnetic signals to a working end of the probe; a spectrometer which acquires diffuse reflectance electromagnetic signals returned from the site probed by ...
Method and apparatus for stimulating stereoscopic depth perception of stereoscopic data inside head mounted displays ...
February 08, 2018 - N°20180041749

Apparatuses and methods are provided that stimulate realistic 3d depth perception from 3d image data. The solution helps the brain perceive a more realistic depth by placing an object, which may or may not be transparent, in virtual 3d space such that the object appears close to the user inside the panoramic viewer in order to give the brain a ...
Apparatus for augmenting human vision
Wisconsin Alumni Research Foundation
February 08, 2018 - N°20180041737

The functional effect of having additional color-sensing cone types in the human eye is implemented by an encoding of some spectral information differently for the left and right eyes. This different encoding for identical features seen by the left and right eyes is interpreted as a perceptively different feature by the human brain, allowing additional spectral information to be conveyed ...
Brain actuated control utilizing visually evoked potentials
February 08, 2018 - N°20180039329

A brain-to-computer interface providing brain actuated control of hardware or software associated with said computer is effected by releasably attaching a plurality of high-impedance dry ag/ag—cl electrodes to selected locations on a human user's scalp; providing a low-noise, high-gain, instrumentation amplifier electrically associated with said plurality of electrodes; utilizing a high-resolution analog-to-digital (a/d) converter electrically associated ...
Diagnostic method for pediatric acute-onset neuropsychiatric syndrome (pans) and pediatric autoimmune neuropsychiatric disorder associated with ...
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
February 08, 2018 - N°20180038870

The present invention provides a panel of at least five clinical analyses or tests (using serum samples) to determine the risk of pediatric acute-onset neuropsychiatric syndrome (pans) and/or pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (pandas) in an individual. These include enzyme linked immunosorbent assays (elisas) to measure antibody titers against neuronal antigens present in the brain; the ...
Epcam aptamers and conjugates thereof
Deakin University
February 08, 2018 - N°20180037892

The present disclosure relates to an epcam aptamer or an epcam aptamer conjugate having bi-functional activity and to uses thereof. In particular, the present disclosure also relates to an aptamer conjugate which binds to the transferrin receptor (tfr) and epcam which is useful for treatment of brain tumours and/or brain metastasis.
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  • 775+ full patent PDF documents of Brain-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
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Prodrugs riluzole and their method of use
Biohaven Pharmaceutical Holding Company Ltd.
February 08, 2018 - N°20180037557

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic ...
N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and ...
Pimco 2664 Limited
February 08, 2018 - N°20180037544

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e. G., diseases) including, inflammation and/or joint destruction ...
High-resolution brain machine interface with magnetically-responsive array switches coupled to an internal antenna
Weinberg Medical Physics, Inc.
February 08, 2018 - N°20180036532

A neuronal tissue-machine interface apparatus includes an array of magnetically-responsive switches positioned in close proximity or contact to neuronal tissue of a human subject, wherein a magnetic environment of the plurality of magnetically-responsive switches varies along the array, and an antenna that is electrically connected to the array, wherein a subset of the magnetically-responsive switches respond to electromagnetic energy received ...
Delivery of polynucleotides using recombinant aav9
Nationwide Children's Hospital
February 08, 2018 - N°20180036431

The present invention relates to adeno-associated virus 9 methods and materials useful for systemically delivering polynucleotides across the blood brain barrier. Accordingly, the present invention also relates to methods and materials useful for systemically delivering polynucleotides to the central and peripheral nervous systems. The present invention also relates to adeno-associated virus type 9 methods and materials useful for intrathecal delivery of polynucleotides. ...
Methods for enhancing the delivery of molecules across the blood brain barrier
Lam Therapeutics, Inc.
February 08, 2018 - N°20180036420

The present invention relates to methods and compositions for enhancing the delivery of an agent across the blood brain barrier utilizing a composition comprising an inhibitor of pikfyve.
Composition for preventing, ameliorating, or treating neurological disease containing osmotin peptide as active ingredient
Industry-academic Cooperation Foundation Gyeongsang National University
February 08, 2018 - N°20180036365

A method of preventing or treating neurological disease includes administering to a subject in need thereof, a composition comprising an osmotin peptide selected from the group consisting of (a) an osmotin peptide having the amino acid sequence of seq id no: 1, and (b) an osmotin peptide having at least one amino acid residue substitution, deletion or insertion in the amino ...
Riluzole prodrugs and their use
Biohaven Pharmaceutical Holding Company Ltd.
February 08, 2018 - N°20180036290

Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic ...
A method of protecting against carbonyl stress induced ischemia-reperfusion injury in the diabetic brain via ...
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
February 08, 2018 - N°20180036270

A method for one of preventing and minimizing diabetes pathology in a mammal, comprising administering to the mammal an effective amount of n-acetylcysteine (nac).
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