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new patent Insulin-like growth factor 1 receptor -specific antibodies and uses thereof
The blood-brain barrier (bbb) prevents transport of molecules larger than 500 daltons from blood to brain. Receptor-mediated transcytosis (rmt) facilitates transport across the bbb of specific molecules that bind receptors on brain endothelial cells that form the bbb.
National Research Council Of Canada


new patent Insulin-like growth factor 1 receptor -specific antibodies and uses thereof
The blood-brain barrier (bbb) prevents transport of molecules larger than 500 dal tons from blood to brain. Receptor-mediated transcytosis (rmt) facilitates transport across the bbb of specific molecules that bind receptors on brain endothelial cells that form the bbb.
National Research Council Of Canada


new patent Targeted therapeutics
The present invention relates to compositions, methods and kits for delivery of active agents (x) to cells or tissues that express proteoglycans. More specifically, the present invention relates to conjugates comprising (hb-linker)n-xm-(linker-hb)o, where hb is a heparin binding protein, x is an active agent such as a therapeutic protein (including a functional fragment or variant thereof), or a therapeutic small molecule, linker is a linker entity and m is an integer of at least 1, and n+o is an integer of at least 1.
The Brigham And Women's Hospital, Inc.


new patent System with an electromagentic field generator with coils for treating tumors and a treating tissue
Treatment apparatus includes a plurality of coils configured to generate time-varying magnetic fields that induce electric fields within a subject. In one example, electric field strengths of at least 1 v/cm are produced in brain tissues exhibiting glioblastoma multiforme (gbm).
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv


new patent Site specific deep brain stimulation for enhancement of memory
The various embodiments described herein include methods, devices, and systems for enhancement of memory. In one aspect, a method includes: (1) implanting intracranial electrodes in a patient, wherein the electrodes are placed selectively at a specific brain site; (2) determining a threshold for eliciting an after-discharge threshold of the patient, and (3) stimulating the electrodes with current set below the after-discharge threshold while the patient is in a particular phase of sleep so as to enhance memory of the patient..
The Regents Of The University Of California


new patent Methods of use for therapeutics targeting the pathogen porphyromonas gingivalis
The invention relates to compositions, formulations, vaccines and antibodies for the prevention and/or treatment of aging and brain disorders, including alzheimer's disease, diabetes, cardiovascular disease, retinal disorders and arthritis. The invention also provides methods of treatment of aging disorders, brain disorders, including alzheimer's disease, diabetes, cardiovascular disease, retinal disorders, and arthritis by administering compositions, formulations, vaccines and antibodies described in the specification.
Cortexyme, Inc.


new patent Brain specific exosome based diagnostics and extracorporeal therapies
Disclosed are methods, compositions, devices, and kits for the isolation of brain-specific exosomes. Specifically, methods, compositions, devices, and unbound kits comprising an isolated brain-specific extracellular vesicle or exosome joined to a first binding agent that is specific for tau, β-amyloid, sloo β, neuron-specific enolase, glycoprotein a2b5, cd133, nq01, synaptophysin, neuronal nuclei, mab 1569, polysialic acid-neural cell adhesion molecule (psa-ncam), or neurogenic differentiation 1 (neurod or beta2), or glycosylated or phosphorylated forms of these molecules, are provided..
Exosome Sciences, Inc.


new patent Task-less optical mapping of brain function using resting state functional connectivity
A method for utilizing an optical system for taskless mapping of brain function includes determining a time series of dynamic light measurements for a plurality of spatially distributed source-detector pairs, receiving the dynamic light measurements over a period of time using the source-detector pairs without dependence on either a task or a change in physiological condition, generating a plurality of temporal correlations between regions of a brain for the light measurements based on the time series of the spatially distributed source-detector pairs and the received dynamic light measurements, producing at least one map of a respective strength of each of a plurality of temporal correlations, producing overlapping source-detector pairs measurements using diffuse optical tomography (dot) geometries, reconstructing data representative of the dynamic light measurements into an image space using at least one dot algorithm, and co-registering dot voxel images obtained by the reconstruction to anatomical information.. .
Washington University


new patent Smart pillow manufacturing the same
The present invention relates to a smart pillow system and a manufacturing method therefor. The smart pillow system detects brain wave information of a sleeper who sleeps on a pillow, notifies a smart phone of the brain wave information, receives the most suitable music or acoustic sound for the sleeper's sound sleep from the smart phone on the basis of the sleeper's brain wave information, and provides the received music or acoustic sound to the sleeper through the pillow.
Gioclavis Co. Ltd.


Cpr patient training mannequin
A cpr patient training mannequin. The cpr patient training mannequin provides for training and teaching individuals in proper cpr technique.

Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein tdp-43

The invention relates to antibodies, antibody fragments and binding agents that specifically recognize tdp-43 associated with frontotemporal dementia (ftd), but not tdp-43 associated with amyotrophic lateral sclerosis (als) or tdp-43 associated with healthy human brain tissue, and antibodies, antibody fragments and binding agents that specifically recognize tdp-43 associated with als, but not tdp-43 associated ftd or tdp-43 associated with healthy human brain tissue.. .
Arizona Board Of Regents On Behalf Of Arizona State University

Anti-metalloprotease antibody for diagnosis and treatment of cancers

Expression of proteolytically active, high molecular weight adam protease is relatively increased in tumour cells that also express the putative tumour stem cell marker cd133. An antibody or antibody fragment such as 8c7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight adam10 protease to thereby detect tumour cells and also as a therapeutic agent for treating cancers, tumours and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumour, renal tumour, prostate cancer, sarcoma and/or melanoma..
Ludwig Institute For Cancer Research Ltd

Method and means to improve the effects of electrical cell and neuron stimulation with random stimulation in both location and time

An electric stimulator for brain, heart, skin and internal organs in animals and plants where the electrodes are distributed on a supporting structure. The supporting structure may be adapted for brain, heart, skin or other internal organs, as for dbs, heart pacemaker, tens, etc.

Peptide-mediated delivery of active agents across the blood-brain barrier

Provided herein are methods for transporting an infectious agent (e.g., a virus) across the blood-brain barrier (bbb). For example, the methods provided herein can be used to make a non-human animal model of an infectious brain disease.
Mayo Foundation For Medical Education And Research

Method of treating or inhibiting the development of brain inflammation and sepsis

A leukotriene c4 and d4 antagonist is used to treat or inhibit brain inflammation and sepsis by acting to inhibit increased capillary permeability and white blood cell extravasation. Potential candidate compounds can be screened in a non-human mammal before or after administration of an inflammation inducing agent into the subarachnoid space by determining their ability to inhibit increased capillary permeability and white blood cell extravasation..
Inflammation Research Center Company Ltd.

Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas

This disclosure concerns the discovery of the use of fenoterol and (r,r)- and (r,s)-fenoterol analogues for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2-adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analogue or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject..
Sri International

Use of cannabinoids in the treatment of epilepsy

The present invention relates to the use of cannabidiol (cbd) in the treatment of focal seizures. In one embodiment the patients suffering from focal seizures are children and young adults.
Gw Research Limited

Nasal foam via cribriform plate for medication delivery to the brain and/or body and for nasal moisturization and hygiene

Methods and compositions for delivering medicine and other substances to the brain and the body via the cribriform plate using foamable compositions are described. Methods and compositions for improving nasal hygiene and moisturizing the nasal cavity using foamable compositions are also described..

Emotion evaluation

In one embodiment, one or more computer-readable non-transitory storage media embody software that is operable when executed to determine, based on cardiac-activity data, a shift in sympathovagal balance (svb) during the period of time; obtain an emotional-state characteristic the emotional-state characteristic being based on brain-wave activity data; and determine, based on the svb shift and the emotional-state characteristic, an estimate of an emotional state of the user during the period of time.. .
Samsung Electronics Company, Ltd.

Cognitive function evaluation apparatus, method, system and program

Provided are a cognitive function evaluation apparatus, a cognitive function evaluation method and system, and a program that can be implemented for non-handicapped persons and persons with severe motor impairment. The apparatus according to the present invention is an apparatus for evaluating cognitive function provided with a processing unit that analyzes and processes a brain wave caused by a plurality of stimulus events including a target and a non-target; estimates a stimulus event selected as the target from the plurality of stimulus events; determines a discrimination score or decoding accuracy; and evaluates cognitive function on the basis of a value of one or more of the discrimination score, the decoding accuracy, any of time courses, and decoding speed.
National Institute Of Advanced Industrial Science And Technology

Compressive plenoptic microscopy

A system and method for quantitative functional neuroimaging through thick brain tissue in live animals. A computational imaging method is disclosed that uses plenoptic image acquisition including a first initialization step that identifies individual neurons by their optical signature and provides a reliable estimate of their position in space and a second stimulation-based image processing step that used acquired calibration data to quickly quantify activity in each identified neuron at video frame-rate..
The Regents Of The University Of California

Innate immune proteins as biomarkers for cns injury

The present invention provides novel markers of the severity of a central nervous system injury, such as spinal cord injury or traumatic brain injury, in a patient. In particular, protein components of inflammasomes in the cerebrospinal fluid that can be used to assess the serverity of central nervous system injury in a patient are disclosed.
University Of Miami

Use of vhh antibodies for the preparation of peptide vectors for delivering a substance of interest and their applications

Use of a variable fragment (vhh antibody) of a camelid single-chain antibody for the preparation of a peptide vector for delivering a substance of interest across the blood-brain barrier or into a cell.. .
Centre National De La Recherche Scientifique (cnrs)

Vh4 antibodies against gray matter neuron and astrocyte

Monoclonal antibodies exhibiting an vh4 signature associated with multiple sclerosis (ms) and clinically isolated syndrome have been produced and sequenced. These antibodies antibodies recognize neuronal nuclei and/or astrocytes in both mouse and human gray matter (gm) brain tissue and thus are useful in binding assays for such.
The Board Of Regents Of The University Of Texas System

Programming systems for deep brain stimulator system

The present technology provides a medical stimulation system having a clinical programmer configured to operate on a computational and memory device having a wireless communication device. The technology also provides a neurostimulator configured to wirelessly communicate with the clinical programmer.
Deep Brain Innovations Llc

Brain portal

The brain portal is a device that allows for easy access to the brain for treatments that require multiple visits inside the brain case to alleviate the need for multiple craniotomies. Such treatments could involve multiple injections of medicines that have to be given over a period of days or weeks.

System and measuring efficacy of cancer therapeutics

The field of this invention is measuring efficacy of cancer treatments. In particular the fields of this invention include studies of drug efficacy, use of animals in medical studies, use of animals in vivariums, and use of rodents, particularly mice.
Mousera, Inc

Device and personalized medicine

The field of this invention is personalized medicine. A tissue sample is taken from a patient, optionally amplified, and injected into animals, such as mice in a vivarium.
Mousera, Inc

Arginine silicate inositol for improving cognitive function

The present disclosure relates to the use of inositol-stabilized arginine (“asi”) for improving cognition. For example, in some implementations, methods include administering an amount of asi effective to improve cognition in humans.
Jds Therapeutics, Llc

Small molecule trail gene induction by normal and tumor cells as an anticancer therapy

Methods and compositions relating to tic10 are described according to aspects of the present invention. The compositions and methods have utility in treating disease, particularly cancer in a subject in need thereof, including a human subject as well as subjects of other species.
The Penn State Research Foundation

Device and spatiotemporal reconstruction of a moving vascular pulse wave in the brain and other organs

The brain appears to have organized cardiac frequency angiographic phenomena with such coherence as to qualify as vascular pulse waves. Separate arterial and venous vascular pulse waves may be resolved.

Rapid, reproducible, non-invasive predictor of cadaveric donor liver graft utilization

A method for rapid, non-invasive assessment of liver function in a brain-dead donor, prior to procurement is presented. Quantitative assessment of liver function can be measured in brain-dead donors in the local donor service area prior to organ procurement by measuring indocyanine green plasma disappearance rates (icg-pdr).
The Regents Of The University Of California

Sideline test to detect concussions that affect visual, proprioceptive, or vestibular brain functions

A method for testing a subject to detect a reduction in cerebral function presumably resulting from mild traumatic brain injury, that affects visual, proprioceptive, and vestibular brain functions includes: providing a user interface, input device, and portable computer into the hands of the test subject suspected of having mild traumatic brain injury; providing an icon on the user interface visible to the subject; rotating the subject holding the computer a predetermined number of revolutions, at a predetermined rate of rotation, to engage the vestibular system of the subject prior to testing; aligning, by the subject, the icon on the screen of the user interface in alignment with a test administrator; maintaining the alignment of the icon on the screen and the test administrator throughout the rotations; and conducting a real-time test for mild traumatic brain injury utilizing the user interface, the user input device, and the associated computer.. .

System and automatic classification of animal behaviors

The field of this invention is classifying animal behaviors. In particular the fields of this invention include using animals in vivariums, such as rodents, particularly mice.
Mousera, Inc

Methods for detecting, diagnosing and treating traumatic brain injury

The present invention relates to methods for detecting, diagnosing and/or treating traumatic brain injury by detecting in a biological sample from a patient the levels of one or more of the metabolites: methionine sulfoxide, pc aa c 34:4, atp, amp, nad+, adp, imp, spermidine, lysopc a c20:3, c18:1, and proline. In some embodiments, the method also includes diagnosing the patient with traumatic brain injury when the one or more metabolites in the biological sample is at a different level than a statistically validated threshold for the one or more metabolites, and ct, mri, or pet indicates traumatic brain injury to the brain of the patient.
William Beaumont Hospital

Novel immunotherapy against several tumors including neuronal and brain tumors

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel immunotherapy against several tumors including neuronal and brain tumors

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel immunotherapy against several tumors including neuronal and brain tumors

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel immunotherapy against several tumors including neuronal and brain tumors

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel immunotherapy against several tumors including neuronal and brain tumors

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh

Novel immunotherapy against several tumors including neuronal and brain tumors

The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer.
Immatics Biotechnologies Gmbh





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This listing is a sample listing of patent applications related to Brain for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Brain with additional patents listed. Browse our RSS directory or Search for other possible listings.


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