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 Novel compounds as rearranged during transfection (ret) inhibitors patent thumbnailnew patent Novel compounds as rearranged during transfection (ret) inhibitors
This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ret dysfunction or where modulation of ret activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (ibs) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, von hippel-lindau syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased ret kinase activity.. .
Glaxosmithkline Intellectual Property Development Limited


 Biomarkers patent thumbnailBiomarkers
The present invention relates to a method for diagnosing inflammatory bowel disease (ibd), the method comprising determining the concentration of at least one ibd-specific biomarker in a sample of the colonic mucocellular layer obtained from a subject.. .
Diagnodus Limited


 Triple endorectal ballooning system for prostate cancer radiotherapy patent thumbnailTriple endorectal ballooning system for prostate cancer radiotherapy
A triple endorectal ballooning (terb) system for prostate cancer radiotherapy may include a first balloon unit, a second balloon unit, a third balloon unit, a central passageway and a cover. The first balloon unit may include a first balloon and a first passageway connected to the first, balloon.
Yonsei University Wonju Industry-academic Cooperation Foundation


 Bowel cleansing composition with improved taste patent thumbnailBowel cleansing composition with improved taste
The present invention provides compositions and methods for facilitating cleansing of the gastrointestinal tract of a patient prior to a diagnostic, surgical or therapeutic procedure. The composition can improve patient compliance, and thus, efficacy of the preparation.
Gavis Pharmaceuticals


 Monoacylglycerols for use in the treatment of malabsorption having a mechanical basis patent thumbnailMonoacylglycerols for use in the treatment of malabsorption having a mechanical basis
Compositions comprising monoacylglycerols (mag), such as sn-1(3) mag, are administered to an individual having or at risk of malabsorption having a mechanical basis, such as malabsorption associated with a biliary fistula, a biliary obstruction, or short bowel syndrome from bowel surgery (resection) or bariatric surgery. Preferably the compositions are administered concurrently with fat-soluble nutrients.
Nestec S.a.


 System and  controlling neural and muscular function patent thumbnailSystem and controlling neural and muscular function
A system and method for controlling neural and muscular function is disclosed in which opsins are introduced into a neural circuit such that the control of optical signals transmitted to the opsins results in the control of neural and muscular functions. Specifically disclosed is the control of the bladder, bowel, and sexual functions of a human..

 Methods, systems and kits of fecal ngal rapid immunochromatographic test patent thumbnailMethods, systems and kits of fecal ngal rapid immunochromatographic test
Disclosed are methods, systems and kits for rapid measurement of fecal ngal levels. The present invention provides a rapid measurement system with fecal sample collection, analyte extraction and immunochromatographic measurement of ngal levels, which can be used for diagnosing and monitoring gastrointestinal inflammation diseases such as chronic inflammatory bowel disease.
Epitope Diagnostics, Inc.


 Methods for distinguishing inflammatory bowel diseases using microbial community signatures patent thumbnailMethods for distinguishing inflammatory bowel diseases using microbial community signatures
Means for identification and comparative analysis of sequence features in metagenomic whole-genome shotgun (wgs) sequence data associated with particular disease states in a subject is disclosed, along with diagnostic methods for distinguishing between different types of inflammatory bowel disease in a subject based on the microbial community signature of the subject.. .
University Of Maryland, Baltimore


 Novel dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders. patent thumbnailNovel dihydropyrimidinoisoquinolinones and pharmaceutical compositions thereof for the treatment of inflammatory disorders.
The present invention relates to novel compounds according to formula i that antagonize gpr84, a g-protein-coupled receptor that is involved in inflammatory conditions, and methods for the production of these novel compounds, pharmaceutical compositions comprising these compounds, and methods for the prevention and/or treatment of inflammatory conditions (for example inflammatory bowel diseases (ibd), rheumatoid arthritis, vasculitis, lung diseases (e.g. Chronic obstructive pulmonary disease (copd) and lung interstitial diseases (e.g.

 Quinine compounds, and optical isomers, preparation method and medical use thereof patent thumbnailQuinine compounds, and optical isomers, preparation method and medical use thereof
The present invention discloses a class of quinine compounds and pharmaceutically acceptable salts, solvates, prodrugs or optical isomers thereof. Also disclosed in the present invention are that the above compounds have a selective antagonistic effect on the receptor subtypes of m1 and m3, but have no significant effect on m2 receptor subtype, and the above compounds are characterized by rapid action, long-lasting efficacy, and low toxic and side-effects when used to treat rhinitis, post-cold rhinitis, chronic trachitis, airway hyperresponsiveness, asthma, chronic obstructive pulmonary diseases, cough, urinary incontinence, frequent urination, unstable bladder syndrome, bladder spasms, bladder inflammation and gastrointestinal diseases such as irritable bowel syndrome, spastic colitis, as well as duodenal and gastric ulcers..
Beijing Fswelcome Technology Development Co., Ltd


Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders


The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase.
Synergy Pharmaceuticals, Inc.


Compositions and methods comprising a defined microbiome and methods of use thereof


The invention features the use of a defined microbial consortia for the replacement of a gut microbiome associated with disease. In particular, the invention provides for the treatment of hyperammonemia, clostridium difficile colitis, hepatic encephalopathy associated with cirrhosis, and inflammatory bowel disease..
The Trustees Of The University Of Pennsylvania


Method, composition and package for bowel cleansing


The present invention provides a highly palatable colon cleansing formulation that utilizes a low chloride electrolyte-replenishing base solution. When formulated with polyethylene glycol and a selected sugar alcohol, the formulation offers the advantages of superior palatability without undesirable concomitant side effects or a decrease in cleansing efficacy..
Braintree Laboratories, Inc.


Fumarate compounds, pharmaceutical compositions thereof, and methods of use


Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, parkinson's disease, huntington's disease, and amyotrophic lateral sclerosis are disclosed.. .

Compositions and methods to image and quantify inflammation


Compositions and methods for assessing inflammation in a subject. The preset disclosure provides compositions for labeling leukocytes with a 19f-containing perfluoropolyether molecule ex vivo.
Celsense, Inc.


Anti-inflammatory proteins and methods of use


A method and composition for reducing or alleviating inflammation in a subject is provided, including administering to the subject a therapeutically effective amount; of one or more isolated proteins respectively comprising an amino acid sequence set forth in seq id nos:1-31, or a biologically active fragment or variant thereof or combinations of these to thereby reduce or alleviate inflammation. Inflammation may be associated with a disease is a disease of the digestive tract such as chronic gastritis or an inflammatory bowel disease such as crohn's disease or ulcerative colitis, or a disease of the respiratory system, such as asthma, emphysema, chronic bronchitis, and chronic obstructive pulmonary disease..
James Cook University


Composition and methods for treating intestinal hyperpermeability


The present invention provides methods, compositions, and kits for treating intestinal hyperpermeability in a subject in need thereof, including conditions such as hyperglycemia and underlying diseases such as diabetes, autism, fibromyalgia, inflammatory bowel disease (ibd), graft versus host disease (gvhd), hiv/aids, multiple organ dysfunction syndrome, irritable bowel syndrome (ibs), celiac disease, eczema, psoriasis, acute pancreatitis, parkinson's disease, depression, chronic fatigue syndrome, asthma, multiple sclerosis, arthritis, ankylosing spondylitis, nonalcoholic fatty liver disease, alcoholic cirrhosis, environmental enteropathy, or kwashiorkor.. .

Amorphous magnesium-substituted calcium phosphate compositions and their uses


Amorphous magnesium-substituted calcium, phosphate compositions and their medical uses are described, in particular for use in delivering cargo materials, such as cargo molecules or cargo nanoparticles contained in pores of the amorphous magnesium-substituted calcium phosphate to cells of the immune system, for example as therapeutic approaches for the treatment of inflammatory bowel diseases, and in particular crohn's disease, autoimmune diseases, allergy and for therapeutic vaccination.. .
Medical Research Council


Tolerogenic dendritic cells to treat inflammatory bowel disease


Methods are disclosed herein for treating or preventing an inflammatory bowel disease in a subject. These methods include administering to a subject an effective amount of tolerogenic dendritic cells, wherein the tolerogenic dendritic cells comprise at least one of an antisense compound specific for cd40, and antisense compound specific for cd80 and an antisense compound specific for cd86..
University Of Pittsburgh - Of The Commonwealth System Of Higher Education


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Modified anti-inflammatory proteins and use


A modified ac-tmp-2 protein lacks one or a plurality of acidic c-terminal amino acids normally present in a full-length or wild-type ac-tmp-2 protein and may also lack one or a plurality of n-terminal amino acids while retaining the amino acid sequence c—s—c at or near the n-terminus. The modified ac-tmp-2 protein may be useful in method and composition for reducing or alleviating inflammation in a subject.
James Cook University


Fumarate compounds, pharmaceutical compositions thereof, and methods of use


Fumarate compounds, pharmaceutical compositions comprising the fumarate compounds, and methods of using fumarate compounds and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, parkinson's disease, huntington's disease, and amyotrophic lateral sclerosis are disclosed.. .

Method for producing amniotic mesenchymal stromal cell composition, cryopreserving the same, and therapeutic agent


An object of the present invention is to provide a method for producing a mesenchymal stromal cell composition, comprising conveniently and aseptically separating high-purity amnion-derived mscs by performing enzyme treatment only once. According to the present invention, the following are provided: a method for producing a mesenchymal stromal cell composition, comprising: performing enzyme treatment of an amnion with collagenase and thermolysis and/or dispase; and filtering the enzyme-treated amnion through a mesh; a method for producing a cryopreserved mesenchymal stromal cell composition; and a therapeutic agent comprising as an active ingredient the mesenchymal stromal cell composition for a disease selected from graft-versus-host disease, inflammatory bowel disease, systemic lupus erythematosus, liver cirrhosis, or radiation enteritis..
Kaneka Corporation


Systems and methods for diagnosis, risk assessment, and/or virtual treatment assessment of visceral ischemia


Systems and methods are disclosed for diagnosis, risk assessment, and/or virtual treatment assessment of visceral ischemia and related disorders. One method includes receiving a patient-specific anatomic model of a patient's visceral vasculature, including visceral vasculature of the patient's visceral organs and bowel; determining a location in the patient-specific anatomic model of the patient's visceral vasculature; determining, for the location in the patient-specific anatomic model, a blood flow characteristic of blood flow through the location in the patient-specific anatomic model of the patient's visceral vasculature; determining a tissue region of the patient's bowel proximate the location in the patient-specific anatomic model of the patient's visceral vasculature; and generating an assessment of blood supply adequacy to the tissue region of the patient's bowel or generating a risk score for risk of disease for the patient's bowel, based on the determined blood flow characteristic and an expected blood flow characteristic associated with the tissue region of the patient's bowel..
Heartflow, Inc.


Antisense compositions and methods of making and using same


The present invention provides pharmaceutical formulations for oral administration of antisense oligonucleotides, such as antisense oligonucleotides against smad7. The pharmaceutical formulations can be used to treat crohn's disease, ulcera-five colitis and chronic inflammatory bowel disease..
Nogra Pharma Limited


Probiotic compositions for use in the treatment of bowel diseases


The present disclosure is directed to methods of administering and compositions comprising lactobacillus plantarum cect 7478, lactobacillus plantarum cect 7485, and pediococcus acidilactici cect 7483 or a mutant or variant thereof. The compositions and methods are useful in the probiotic treatment of bowel diseases or conditions such as inflammatory bowel disease, irritable bowel syndrome, and abdominal distension and bloating..
Ab-biotics S.a.


Systems and methods for diagnosis, risk assessment, and/or virtual treatment assessment of visceral ischemia


Systems and methods are disclosed for diagnosis, risk assessment, and/or virtual treatment assessment of visceral ischemia and related disorders. One method includes receiving a patient-specific anatomic model of a patient's visceral vasculature, including visceral vasculature of the patient's visceral organs and bowel; determining a location in the patient-specific anatomic model of the patient's visceral vasculature; determining, for the location in the patient-specific anatomic model, a blood flow characteristic of blood flow through the location in the patient-specific anatomic model of the patient's visceral vasculature; determining a tissue region of the patient's bowel proximate the location in the patient-specific anatomic model of the patient's visceral vasculature; and generating an assessment of blood supply adequacy to the tissue region of the patient's bowel or generating a risk score for risk of disease for the patient's bowel, based on the determined blood flow characteristic and an expected blood flow characteristic associated with the tissue region of the patient's bowel..
Heartflow, Inc.


Halter bib athletic garment


A halter bib athletic garment is described herein. A halter bib athletic garment may be removed or lowered without removing a jersey by simply pulling a halter strap over the head of a wearer.
Bell Sports, Inc.


Treatments for disorders using guanylate cyclase c agonists


The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (ibd), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (bph), pain, salt retention or fluid retention.. .
Ironwood Pharmaceuticals, Inc


Systems, devices and methods for anti-tl1a therapy


The present invention relates to biomarker genes for diagnosing and treating diseases. Provided herein are systems and methods of diagnosing a disease in a patient based on the patient's expression levels of biomarker genes.
Cedars-sinai Medical Center


Lactoferrin for the treatment of ibd associated with bacterial invasion


The present invention relates to a substance and an oral formulation for modified release dosage for use in the treatment of inflammatory bowel disease due to escherichia coli invasion.. .
Giellepi S.p.a.


Treatment of constipation-predominant irritable bowel syndrome


The invention provides methods for treating a patient with constipation-predominant irritable bowel syndrome by administering a therapeutically effective dose of linaclotide.. .
Forest Laboratories Holdings Limited


Methods and compositions for bowel cleansing before a medical procedure


Described are kits, food compositions and methods for cleaning the bowel, e.g., in preparation for a medical procedure, e.g., a diagnostic or treatment procedure, such as an endoscopic or surgical procedure, or radiologic imaging such as ct colography.. .
The General Hospital Corporation


Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use


The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “apsac compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (copd), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc..
Pimco 2664 Limited


Compositions and methods for treatment and prophylaxis of gastrointestinal diseases


Methods and compositions for treating inflammatory bowel disease, irritable bowel syndrome, and travelers' diarrhea involve the use of targeted antibiotics in combination with probiotic formulations. The probiotics mitigate many of the deleterious side effects associated with antibiotic use and permit the antibiotic to be administered at a higher dose and for a longer duration than would otherwise be possible in the absence of the probiotic.

Il4 conjugated to antibodies against extracellular matrix components


A conjugate comprising interleukin-4 (il4) and a specific binding member is disclosed. The specific binding member preferably binds an extra-cellular matrix component associated with neoplastic growth and/or angiogenesis, and the conjugate may be used for targeting il4 to tissues in vivo.
Philogen S.p.a.


Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders


The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorder, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase.
Synergy Pharmaceuticals, Inc.


Oral rehydration solution


Provided herein are oral rehydration compositions useful for treating a dehydrated subject. Exemplary compositions provided herein are oral rehydration compositions customized for use with children, athletes, and subjects having short bowel syndrome.
Mayo Foundation For Medical Education And Research


Organ retractor


A medical device of the present invention includes one or more anchors and an elongated member. Advantageously, the elongated member may be coupled to the anchors.

Bowel sound analysis method and system


A bowel sound analysis method and system utilizes an audio collection apparatus to continuously monitor an abdominal cavity of an examinee and collect a bowel sound signal of an intestinal tract inside the abdominal cavity, converts the bowel sound signal into a digital signal, then removes noise from the digital signal by using higher-order statistics (hos) and captures a high-complexity feature from the digital signal by using fractal dimension algorithm, and subsequently defines the high-complexity feature as an intestinal motility signal. The refore, according to the intestinal motility signal, a time point when intestinal motility occurs in the intestinal tract inside the abdominal cavity of the examinee can be learned, and bowel sound features such as the amplitude, frequency, and period of the intestinal motility signal may further be analyzed to determine a health condition of the intestinal tract..
Chimei Medical Center


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Apparatus and fixing and shortening bowel at the time of endoscopy


Disclosed are a device and method for fixing and shortening the bowel at the time of endoscopy. The device and method can improve the shortening efficiency of the bowel when compared with the existing endoscope surgery, reduce the inspection time, and mitigate patient inconvenience.



Bowel topics:
  • Bowel Disease
  • Inflammatory Bowel Disease
  • Irritable Bowel Syndrome
  • Inflammation
  • Mercaptopurine
  • Probiotics
  • Abdominal Pain
  • Discomfort
  • Bowel Movement
  • Gastrointestinal
  • Ulcerative Colitis
  • Rheumatoid Arthritis
  • Jejunal Tube
  • Spring Mechanism
  • Small Bowel


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    This listing is a sample listing of patent applications related to Bowel for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Bowel with additional patents listed. Browse our RSS directory or Search for other possible listings.


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