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Bowel

Bowel-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Novel compounds as rearranged during transfection (ret) inhibitors
Glaxosmithkline Intellectual Property Development Limited
April 12, 2018 - N°20180099976

This invention relates to novel compounds which are inhibitors of the rearranged during transfection (ret) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and/or secretion and/or abdominal disorders or diseases and/or treatment related to diseases related to ...
Compositions and methods for treating irritable bowel syndrome and related disorders
Crestovo Holdings Llc
April 12, 2018 - N°20180099011

The present disclosure is in the field of pharmaceutical compositions suitable for the treatment of diseases in mammals. The disclosure provides novel compositions comprising non-pathogenic fecal microbes for treating irritable bowel syndrome and related diseases. The disclosure also provides methods for treating a subject with the compositions disclosed herein.
Tissue-engineered bowel constructs
Wake Forest University Health Sciences
April 05, 2018 - N°20180093016

Methods are disclosed for forming tissue engineered, tubular bowel constructs from intestinal circular smooth muscle cells and enteric neural progenitor cells. The intestinal smooth muscle cells and neural progenitor cells can be seeded on a mold with a surface texture that induces longitudinal alignment of the intestinal smooth muscle cells and co-cultured until an innervated aligned smooth muscle sheet is ...
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Human milk permeate compositions and methods of making and using same
Prolacta Bioscience, Inc.
April 05, 2018 - N°20180092374

This disclosure features human milk permeates and compositions containing the same obtained from fractionated whole human milk. The oligosaccharide rich permeate and permeate compositions of the present invention are useful as nutritional supplements for pre-term and full term infants, for establishing or maintaining gut flora and for treating the symptoms of inflammatory bowel disease.
Integrin beta7 antagonists and methods of treating crohn's disease
Genentech, Inc.
March 29, 2018 - N°20180086833

Methods of treating gastrointestinal inflammatory disorders such as inflammatory bowel diseases including crohn's disease are provided. Also provided are methods of administering and dosing integrin beta7 antagonists, such as anti-integrin beta7 antibodies. In addition, methods of administrating and dosing such integrin beta7 antagonists to induce remission or to induce and maintain remission of crohn's disease are provided.
Anti-inflammatory peptides and methods for treating inflammatory diseases
Institut National De La Recherche Agronomique (inra)
March 29, 2018 - N°20180085429

A method for preventing or treating an inflammatory disease, such as inflammatory bowel disease and crohn disease, is presented. The method includes administering to a patient a polypeptide having the amino acid sequence of seq id no: 1, a conservative derivative or a fragment thereof, a nucleic acid sequence encoding said polypeptide, a vector comprising said nucleic acid sequence or a ...
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Bowel Patent Applications
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inventor
  • 226+ full patent PDF documents of Bowel-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
Protagonist Therapeutics, Inc.
March 22, 2018 - N°20180079783

The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease.
Oral peptide inhibitors of interleukin-23 receptor and their use to treat inflammatory bowel diseases
Protagonist Therapeutics, Inc.
March 22, 2018 - N°20180079782

The present invention provides novel peptide inhibitors of the interleukin-23 receptor, and related compositions and methods of using these peptide inhibitors to treat or prevent a variety of diseases and disorders, including inflammatory bowel disease.
Immunomodulating tumor necrosis factor receptor 25 (tnfr25) agonists, antagonists, and immunotoxins
University Of Miami
March 22, 2018 - N°20180078611

This document provides novel compositions and methods utilizing immunomodulating agents that can stimulate or indirectly augment the immune system, or can have an immunosuppressive effect. Tnfr25 agonists disclosed herein have an anti-inflammatory and healing effect. They can be used, e. G., to treat disease caused by asthma and chronic inflammation, such as inflammatory bowel diseases including ulcerative colitis and crohn's ...
Exosomes sourced from granulocytic myeloid-derived suppressor cells and application thereof
Jiangsu University
March 22, 2018 - N°20180078581

Provided are exosomes sourced from a granulocyte myeloid-derived suppressor cell and an application thereof. The exosomes are named as g-mdsc exo. Also provided is a use of the exosomes in preparing a drug used for suppressing autoimmune diseases. The g-mdsc exo can effectively suppress proliferation of cd4+t cells in vitro, promote induced proliferation of t regulatory (treg) cells, alleviate ...
Diaminopyrimidine derivatives and processes for the preparation thereof
Yuhan Corporation
March 15, 2018 - N°20180072705

The present invention provides a diaminopyrimidine derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same, and a use thereof. The diaminopyrimidine derivative or its pharmaceutically acceptable salt functions as a 5-ht4 receptor agonist, and therefore can be usefully applied for preventing or treating dysfunction in gastrointestinal motility, one of the gastrointestinal ...
Compositions and methods for treating microbiota-related psychotropic conditions and diseases
March 15, 2018 - N°20180071268

In alternative embodiments, the invention provides compositions and methods for treating, ameliorating and preventing various disorders and conditions in manunals, including genetically-predisposed and chronic disorders, where the microbial or bacterial flora of the bowel is at least one causative or symptom-producing factor, for example, where the microbial or bacterial flora of the bowel manufactures neurotoxins or neurotoxic agents that enter ...
Use of ferric citrate in the treatment of iron-deficiency anemia
Keryx Biopharmaceuticals, Inc.
March 15, 2018 - N°20180071243

Described herein are methods for treating patients with iron-deficiency anemia (ida), comprising administering ferric citrate to such patients. In certain aspects, the patients treated for iron-deficiency anemia have a gastrointestinal disorder, such as inflammatory bowel disease, inflammatory bowel syndrome, crohn's disease, microscopic colitis (such as collagenous or lymphocytic colitis), or chemically-induced colitis (e. G., nsaid (nonsteroidal anti-inflammatory drug)-induced colitis). ...
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Bowel Patent Applications
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For professional research & prior art discovery
inventor
  • 226+ full patent PDF documents of Bowel-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Antibodies and methods for wnt pathway-related diseases
Novartis Ag
March 08, 2018 - N°20180066067

The transmembrane e3 ubiquitin ligases znrf3 and rnf43 are negative regulators of β-catenin and the wnt signaling pathway in eukaryotic cells. The activity of znrf3 can be modulated by antibody binding to its extracellular domain, thus causing an increase in wnt signaling. The znrf3 antagonizing antibodies can be used to treat diseases with low wnt signaling, such as ...
Increasing the half-life of a full-length or a functional fragment of variant anti-human tnf-alpha antibody
Dnx Biotech, Llc
March 08, 2018 - N°20180066049

Tumor necrosis factor-α (tnfα) promotes an inflammatory response resulting in many clinical problems associated with autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa, and refractory asthma. Dysregulation of tnf production is implicated in a variety of human diseases including alzheimer's disease, cancer, major depression, and inflammatory bowel disease. These disorders ...
Compounds targeting proteins, compositions, methods, and uses thereof
Biotheryx, Inc.
March 08, 2018 - N°20180065952

The present invention provides modulators of protein function, to restore protein homeostasis, including cytokine, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of protein-mediated diseases, disorders, ...
Site specific curcumin-polymer molecular complexes and methods of treating colon diseases and inflammation
South Dakota Board Of Regents
March 08, 2018 - N°20180064821

Methods and materials relating to a medicament preparation comprising a curcuminoid component, such as curcumin, and a polymer component having a backbone comprising polymethacrylate or methyl methacrylate provided as a curcuminoid-polymer complex, which enhances the solubility, stability and bioavailability of the curcumin component and are useful for the treatment of various inflammatory diseases and conditions when delivered to the gastro-intestinal ...
Hydromorphone and naloxone for treatment of pain and opioid bowel dysfunction syndrome
Euro-celtique S.a.
March 08, 2018 - N°20180064705

The present invention relates to prolonged release pharmaceutical dosage forms comprising hydromorphone or a pharmaceutically acceptable salt thereof and naloxone or a pharmaceutically acceptable salt thereof for use in the treatment of pain.
Anti-il-25 antibodies and uses thereof
Regeneron Pharmaceuticals, Inc.
March 01, 2018 - N°20180057583

The present invention provides antibodies that bind to human interleukin-25 (il-25) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human il-25 with high affinity. In certain embodiments, the invention includes antibodies that bind human il-25 and block il-25-mediated cell signaling. The antibodies of the invention may be fully human, non-naturally occurring ...
Methods of treating inflammatory bowel disease with ifn-gamma therapy
Cedars-sinai Medical Center
February 22, 2018 - N°20180051078

The present invention describes methods for treating inflammatory disorders of the gastrointestinal tract, including but not limited to inflammatory bowel disease (ibd), crohn's disease (cd), ulcerative colitis (uc) and/or medically refractory ulcerative colitis (mr-uc) using anti-ifng therapy. The present invention also describes a process for patient risk stratification.
Novel vista-ig constructs and the use of vista-ig for treatment of autoimmune, allergic and inflammatory ...
King's College London
February 22, 2018 - N°20180051070

The present invention relates to a fusion proteins comprising regulatory t cell protein, vista (v-domain immunoglobulin suppressor of t cell activation (pd-l3) and an immunoglobulin protein (ig), preferably also containing a flexible linker intervening the vista and ig fc polypeptide. The invention also provides the use of vista polypeptides, multimeric vista polypeptides, vista-conjugates (e. G., vista-ig), and vista antagonists for ...
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