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|| List of recent Bowel-related patents
| Genotoxicity as a biomarker for inflammation|
The invention provides a method for detection of inflammatory disease in a subject that comprises assaying a test sample of peripheral blood from the subject for a marker of dna damage. An elevated amount of marker present in the test sample compared to control sample is indicative of inflammatory disease activity, including sub-clinical inflammation.
| Humanized antibodies against light and uses thereof|
The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the light polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g.
| Organic compounds|
The present invention relates to human thymic stromal lymphopoietin (htslp) antibodies and especially those which neutralize htslp activity. It further relates to methods for using anti-htslp antibody molecules in diagnosis or treatment of htslp related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and hodgkin's lymphoma..
|Compositions and methods for treatment of irritable bowel syndrome with 5-aminosalicylate|
Embodiments are directed to compositions and related methods for treating gastrointestinal disorders with a granulated mesalamine formulation. In some embodiments, the gastrointestinal disorder being treated is irritable bowel syndrome (ibs).
|Disialyllacto-n-tetraose (dslnt) or variants, isomers, analogs and derivatives thereof to prevent or inhibit bowel disease|
The invention provides formulations comprising isolated disialyllacto-n-tetraose (dslnt) or variants, isomers, analogs and derivatives thereof.. .
|Anti-light antibody therapy for inflammatory bowel disease|
The present invention provides safe therapeutic doses of an antagonist of human light (lymphotoxin-like, exhibits inducible expression and competes with herpes virus glycoprotein d for herpes virus entry mediator (hvem), a receptor expressed by t lymphocytes), as well as methods of monitoring whether a therapeutic dose of an anti-light antagonist is safe.. .
|Odor barrier film|
A multilayer film for ostomy and bowel management applications includes a barrier layer comprising at least about 90% wt. Nylon 6/69.
|5-ht3 receptor modulators, methods of making, and use thereof|
Novel 5-ht3 receptor modulators are disclosed. These compounds are used in the treatment of various disorders, including chemotherapy-induced nausea and vomiting, post-operative nausea and vomiting, and irritable bowel syndrome.
|Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders|
The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase.
|Antibodies that bind and block triggering receptor expressed on myeloid cells-1 (trem-1)|
The invention relates to antibodies that are capable of specifically binding trem-1 and preventing the activation of trem-1, a protein expressed on monocytes, macrophages and neutrophils. Such antibodies find utility in the treatment of individuals with an inflammatory disease, such as rheumatoid arthritis and inflammatory bowel disease..
|Tetra-substituted ndga derivatives via ether bonds and carbamate bonds and their synthesis and pharmaceutical use|
Disclosed are nordihydroguaiaretic acid derivative compounds including various end groups bonded by a carbon atom or heteroatom though a side chain bonded to the respective hydroxy residue o groups by an ether bond or a carbamate bond, pharmaceutical compositions, methods of making them, and methods of using them and kits including them for the treatment of diseases and disorders, in particular, diseases resulting from or associated with a virus infection, such as hiv infection, hpv infection, or hsv infection, an inflammatory disease, such as various types of arthritis and inflammatory bowel diseases, a metabolic disease, such as diabetes, a vascular disease, such as hypertension and macular degeneration, or a proliferative disease, such as diverse types of cancers.. .
|Methods for diagnosis and prognosis of inflammatory bowel disease using cytokine profiles|
The present invention relates to the field of inflammatory bowel disease. More specifically, the present invention relates to the use of cytokines to detect, diagnose, and assess inflammatory bowel disease.
|Method for treating inflammation|
A method for treating il-20 induced inflammation. An antagonist to il-20 is administered to treat inflammation and associated diseases.
|Obesity treatment tools and methods|
Various obesity treatment tools and methods are described herein, as well as treatments for other gastric-related diseases, e.g., gerd. Treatment includes reducing the size of the stomach pouch to limit the caloric intake as well as to provide an earlier feeling of satiety.
|Pterostilbene and curcumin combination for treatment of oxidative stress and inflammation|
A pharmaceutical composition is provided comprising a therapeutically effective amount of pterostilbene, a therapeutically effective amount of curcumin, and a pharmaceutically acceptable carrier. The embodiments of the pharmaceutical compositions can have lipid lowering properties, or alternatively can have properties that can treat oxidative stress, by decreasing inflammation or inflammatory processes contributing to digestive disorders or cancer.
|Method for prevention or treatment of intractable inflammatory bowel disease|
An object of the present invention is to provide methods for preventing or treating a steroid-resistant or steroid-dependent inflammatory bowel disease. The object can be achieved by a method for preventing or treating a steroid-resistant or steroid-dependent inflammatory bowel disease in a patient in need of the prevention or treatment of the inflammatory bowel disease, comprises administering an effective amount of adrenomedullin, a modified product thereof having an activity of suppressing steroid-resistant or steroid-dependent inflammation, or a salt thereof having an activity of suppressing steroid-resistant or steroid-dependent inflammation, to the patient..
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