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|| List of recent Bowel-related patents
| Methods for compositions for the treatment of irritable bowel syndrome|
A method for a prevention and/or treatment of irritable bowel syndrome or amelioration of a symptom thereof in a subject, comprises administering to said subject an effective amount of a compound of formula i:. .
| Methods for treating vascular leak syndrome|
Disclosed are methods for treating vascular leak syndrome. Further disclosed are methods for treating vascular leakage due to inflammatory diseases, inter alia, sepsis, lupus, irritable bowel disease.
| Pharmaceutical compositions for extended release of azo-bonded 5-aminosalicylic acid compositions|
Gastric retentive dosage forms for sustained release of an azo-bonded prodrug of 5-aminosalicylic acid (5-asa) are described which may allow once- or twice-daily dosing for both acute and long-term treatment of inflammatory bowel disorders. Methods of treatment using the dosage forms and methods of making the dosage forms are also described..
| Multiparticulate l-menthol formulations and related methods|
A multiparticulate formulation includes a plurality of individual spheroidal enteric coated cores containing l-menthol from an at least 80% pure l-menthol source. A subcoat is beneath the enteric coat.
|Process for the synthesis of substituted gamma lactams|
The present invention provides synthetic processes for the preparation of a variety of well-defined substituted gamma lactams. The compounds that can be prepared by the process of the invention are useful for treating a variety of conditions.
|Tetrahydroisoquinolin-1-one derivative or salt thereof|
To provide a pharmaceutical, in particular a compound which can be used as a therapeutic agent for irritable bowel syndrome (ibs). It was found that a tetrahydroisoquinolin-1-one derivative having an amide group at the 4-position or a pharmaceutically acceptable salt thereof has an excellent bombesin 2 (bb2) receptor antagonistic action.
|Therapeutic polyamine compositions and their synthesis|
This invention relates to a process of synthesis and composition of open chain (ring), closed ring, linear branched and or substituted polyamines, polyamine derived tyrosine phosphatase inhibitors and ppar partial agonists/partial antagonists via a series of substitution reactions and optimizing the bioavailability and biological activities of the compounds. Polyamines prevent the toxicity of neurotoxins and diabetogenic toxins including paraquat, methyphenyl pyridine radical, rotenone, diazoxide, streptozotocin and alloxan.
|Percutaneous implant and ostomy method|
A percutaneous ostomy implant for implantation into the abdominal wall of a patient is provided, which includes a connecting member for mounting an external detachable device thereto; a first tubular ingrowth member depending from the connecting member; and a second tubular ingrowth member depending from the connecting member and being radially outwardly spaced from the first tubular ingrowth member. The first tubular ingrowth member is configured and dimensioned to receive a bowel segment within it to allow the stoma and serosal tissue of that bowel segment to infiltrate the first tubular ingrowth member.
|Morpholinoalkyl fumarate compounds, pharmaceutical compositions, and methods of use|
Morpholinoalkyl fumarates, pharmaceutical compositions comprising the morpholinoalkyl fumarates, and methods of using morpholinoalkyl fumarates and pharmaceutical compositions for treating neurodegenerative, inflammatory, and autoimmune disorders including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, parkinson's disease, huntington's disease, and amyotrophic lateral sclerosis are disclosed.. .
|Methods for diagnosing irritable bowel syndrome|
The present invention provides methods, systems, and code for accurately classifying whether a sample from an individual is associated with irritable bowel syndrome (ibs). In particular, the present invention is useful for classifying a sample from an individual as an ibs sample using a statistical algorithm and/or empirical data.
|Method for detecting methylation of colorectal cancer specific methylation marker gene for colorectal cancer diagnosis|
The present invention relates to a method for detecting methylation of the bowel-cancer-specific methylation marker gpm6a (nm_201591, glycoprotein m6a) gene in order to diagnose bowel cancer, and more specifically relates to a method for providing information for diagnosing bowel cancer by detecting the methylation of a bowel-cancer-specific marker gene that is specifically methylated in bowel cancer cells. The method for detecting methylation and a diagnostic composition, kit and nucleic-acid chip according to the present invention can be used to advantage in diagnosing bowel cancer more accurately and quickly than by normal methods as they permit bowel cancer to be diagnosed at the initial genetic transformation step and so allow early diagnosis..
|Food ingredients produced from high amylose wheat|
Provided are food and drink ingredients produced from wheat grain which has a low level (2-30%) of total starch branching enzyme ii activity and an amylose content in the starch of at least 50% (w/w), and processes for producing and using the ingredients. Also provided are foods produced from the ingredients which may be used in humans to improve one or more parameters of metabolic health, bowel health or cardiovascular health..
Therapeutic peptides having guanylyl cyclase c agonist activity are disclosed. The therapeutic peptides are analogues of the e.
|Method and kit for bowel preparation|
The present invention provides methods and taste-modifying kits for facilitating cleansing of the gastrointestinal tract of a patient prior to a diagnostic, surgical or therapeutic procedure. The methods and taste-modifying kits can improve patient compliance, and thus, efficacy of the preparation.
|Nutritional compositions including branched chain fatty acids for improving gut barrier function|
Nutritional compositions for improving, treating and/or preventing various medical conditions and methods of using same are provided. Such medical conditions include infection, sepsis, malabsorption, allergy, inflammatory bowel disease, and diarrhea among others.
|Bowel packing device having a tether|
A kit for packing the bowels of a subject. The kit comprises an elastomeric bowel packing device manually positioned within the subject to retain the bowels of the subject in an operational displaced position and to provide a surgical operational space; and an elongate tether having a distal end coupled to the device via an attachment arrangement..
|Screening methods and pharmaceutical compositions for the treatment of inflammatory bowel diseases|
The present invention relates to screening methods and pharmaceutical compositions for the treatment of inflammatory bowel disease. More particularly, the present invention relates to a method for screening a plurality of test substances useful for the prevention or treatment of an inflammatory bowel disease comprising the steps consisting of (a) testing each of the test substances for its ability to restore the integrated stress response and (b) and positively selecting the test substances capable of restoring said integrated stress response.
|Dosage form containing oxycodone and naloxone|
The present invention concerns a dosage form comprising oxycodone and naloxone which is characterized by specific in vivo parameters such as tmax, cmax, auct value, mean bowel function score and/or duration of analgesic efficacy.. .
|Heterocyclic compounds and their uses|
Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (sle), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity. The present invention also enables methods for treating cancers that are mediated, dependent on or associated with pi 105 activity, including but not restricted to leukemias, such as acute myeloid leukaemia (aml) myelo-dysplastic syndrome (mds) myelo-proliferative diseases (mpd) chronic myeloid leukemia (cml) t-cell acute lymphoblastic leukaemia (t-all) b-cell acute lymphoblastic leukaemia (b-all) non hodgkins lymphoma (nhl) b-cell lymphoma and solid tumors, such as breast cancer..
|Gallium compounds and methods of use to treat inflammatory bowel disease|
Provided are formulations and methods for treating inflammatory bowel disease, including crohn's disease, ulcerative colitis, and johne's disease. The formulations provided comprise pharmaceutically acceptable gallium compounds; the methods provided comprise means of using such formulations in the treatment of inflammatory bowel disease and closely related disorders..
|Bowel packing device having a support structure|
An elastomeric device for packing the bowels of a subject comprising: a central portion and one or more flaps collectively manually positionable within the subject to retain the bowels of the subject in an operational, displaced position and to provide a surgical operational space; and a support structure disposed in at least one of the central portion and the flaps configured to provide rigidity to the device.. .
|Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders|
The invention provides novel guanylate cyclase-c agonist peptides and their use in the treatment of human diseases including gastrointestinal disorders, inflammation or cancer (e.g., a gastrointestinal cancer). The peptides can be administered either alone or in combination with an inhibitor of cgmp-dependent phosphodiesterase.
|Anti-il 13 human antibodies|
The present invention relates to human anti-il-13 binding molecules, particularly antibodies, and to methods for using anti-il-13 antibody molecules in diagnosis or treatment of il-13 related disorders, such as asthma, atopic dermatitis, allergic rhinitis, fibrosis, inflammatory bowel disease and hodgkin's lymphoma.. .
|Substituted fused tricyclic compounds, compositions and medicinal applications thereof|
The present invention relates to substituted fused tricyclic compounds of formula (i) or (ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by jak activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by jak activity.
|Role of ifng methylation in inflammatory bowel disease|
The invention relates to method of diagnosing susceptibility to inflammatory bowel disease (ibd) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in ifng dna methylation. In one embodiment, the present invention provides a method of diagnosing susceptibility to inflammatory bowel disease (ibd) in an individual by obtaining a sample from the individual, assaying the sample to determine the presence or absence of one or more risk genetic variants and/or an increase in ifng dna methylation relative to a normal subject, and diagnosing susceptibility to inflammatory bowel disease based on the presence of one or more risk genetic variants and/or an increase in ifng dna methylation relative to a normal subject.
|Methods of diagnosing and treating intestinal granulomas and low bone density in inflammatory bowel disease|
The present invention relates to methods of diagnosing inflammatory bowel disease (ibd) in an individual by determining the presence of at least one risk genetic variant and/or at least one risk serological marker. In one embodiment, the presence of at least one risk genetic variant is indicative of granuloma.
|Gene array technique for predicting response in inflammatory bowel diseases|
Disclosed are methods for classifying individuals having or suspected of having an inflammatory bowel disease, such as crohn's disease or ulcerative colitis, as ‘responders’ or ‘non-responders’ to first-line treatment, generally comprising the steps of a) obtaining a biological sample from the individual, b) isolating mrna from the biological sample c) determining a gene expression profile from the biological sample; and d) comparing the gene expression profile of the individual to a reference gene expression profile or other suitable control such that changes in expression can be used to stratify individuals and predict efficacy of first-line therapy. A gene expression system is further provided for carrying out these methods..
|Methods of diagnosing ulcerative colitis and crohn's disease|
The present invention relates to methods of prognosing inflammatory bowel disease (ibd) in an individual by determining the presence of at least one risk genetic variant and/or at least one risk serological marker. In one embodiment, the presence of risk serological marker anca is indicative of an aggressive form of ulcerative colitis.
|Methods and compositions for determining responsiveness to treatment with a tnf-alpha inhibitor|
The present invention is directed to methods and compositions useful for predicting the efficacy of a tnfα inhibitor for treating an inflammatory bowel disease (ibd). The invention includes, in one embodiment, determining the level of expression of tnfα by delivering a labeled anti-tnfα antibody on to the cells of the intestinal mucosa of a subject having ibd, whereby the tnfα level of expression can be used to predict whether the subject will be responsive or not to the antibody therapy.
|Novel compounds, isomer thereof, or pharmaceutically acceptable salts thereof as vanilloid receptor antagonist; and pharmaceutical compositions containing the same|
The present disclosure provides a pharmaceutical composition for preventing or treating a disease such as pain, migraine, arthralgia, neuralgia, neuropathies, nerve injury, skin disorder, urinary bladder hypersensitiveness, irritable bowel syndrome, fecal urgency, a respiratory disorder, irritation of skin, eye or mucous membrane, stomach-duodenal ulcer, inflammatory diseases, ear disease, heart disease and so on.. .
|Arylsulfonyl pyrazoline carboxamidine derivatives as 5-ht6 antagonists|
This invention concerns arylsulfonyl pyrazoline carboxamidine derivatives as antagonists of 5-ht6 receptors, to methods for the preparation of these compounds and to novel intermediates useful for their synthesis. The invention also relates to the uses of such compounds and compositions, particularly their use in administering them to patients to achieve a therapeutic effect in parkinson's disease, huntington's chorea, schizophrenia, anxiety, depression, manic depression, psychoses, epilepsy, obsessive compulsive disorders, mood disorders, migraine, alzheimer's disease, age related cognitive decline, mild cognitive impairment, sleep disorders, eating disorders, anorexia, bulimia, binge eating disorders, panic attacks, akathisia, attention deficit hyperactivity disorder, attention deficit disorder, withdrawal from abuse of cocaine, ethanol, nicotine or benzodiazepines, pain, disorders associated with spinal trauma or head injury, hydrocephalus, functional bowel disorder, irritable bowel syndrome, obesity and type-2 diabetes.
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Bowel topics: Bowel Disease, Inflammatory Bowel Disease, Irritable Bowel Syndrome, Inflammation, Mercaptopurine, Probiotics, Abdominal Pain, Discomfort, Bowel Movement, Gastrointestinal, Ulcerative Colitis, Rheumatoid Arthritis, Jejunal Tube, Spring Mechanism, Small Bowel
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