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|| List of recent Bowel-related patents
| Mirna biomarkers for ulcerative colitis|
Methods for diagnosing inflammatory bowel disease and ulcerative colitis using mirna biomarkers for these diseases are provided. Differential expression of the mirna biomarkers in blood fractions, e.g., platelets, of diseased individuals as compared to expression levels in normal individuals indicates the presence of ibd or ulcerative colitis.
| Treatments for gastrointestinal disorders|
The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including irritable bowel syndrome and constipation.. .
Ironwood Pharmaceuticals, Inc.
|Tl1a model of inflammation fibrosis and autoimmunity|
This invention relates transgenic animals that overexpress tl1a in a tissue specific manner to model inflammatory bowel disease (ibd), such as colitis, crohn's disease and ulcerative colitis, fibrosis, and related inflammatory diseases and conditions. Tl1a transgenic animals constitutively express both tl1a and gfp in lymphoid and myeloid cell lineages, allowing convenient identification and sorting of immune cells involved in ibd disease progression, such as t-cells, antigen presenting cells (apc), and dendritic cells (dc).
Cedars-sinai Medical Center
|Formulation for treatment of irritable bowel disease|
The present invention relates to an effective formulation for the treatment or the prevention of irritable bowel syndrome, a method for treating irritable bowel syndrome, and processes for preparing such formulations.. .
Aboca S.p.a. Societa' Agricola
|Integral child training toilet|
An integral training potty comprised of a child safety seat and waste collection apparatus, allowing a small child to evacuate his or her bowel or bladder. The waste collection apparatus being removable, without disturbing or removing the seated child.
An enema includes a liquid in a dispenser having a bottle, a nozzle attached to the bottle, and a valve. The valve may be a membrane having a slit and a thickness of at most 0.90 mm.
C.b. Fleet Company, Incorporated
|Treatment of inflammatory bowel disease|
Wherein x, y, b, r2, r3, r4, r5, r6 and n have the meanings found herein.. .
|Method for treating intestinal diseases presenting at least one inflammatory component|
The present disclosure relates to methods for treating intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease or diverticular disease and/or maintaining remission of intestinal diseases presenting at least one inflammatory component such as inflammatory bowel disease (ibd) or diverticular disease using budesonide mmx compositions.. .
Cosmo Technologies Limited
|Slowly fermentable soluble dietary fiber|
The embodiments described herein provide a method for improving bowel health by increasing short chain fatty acid concentration in the colon of a mammal including administering to the mammal a composition having from about 0.1 grams to about 50 grams of a treated bran product. After administration, the treated bran product results in an increased short chain fatty acid production during fermentation in the colon as compared to untreated bran fermented in the colon..
Purdue Research Foundation
|Method for prevention of colectomy|
The present invention relates to methods of preventing or reducing the need of colectomy. In particular, the present invention relates to an oligonucleotide, for use in the treatment of an inflammatory bowel disease, such as ulcerative colitis (uc) or crohn's disease, in a subject that is refractory or responds insufficiently or is intolerant to anti-inflammatory therapy, wherein said oligonucleotide is repetitively administered as a single exposure..
Index Pharmaceuticals Ab
Self-stabilized encapsulated imaging system
Wireless capsule endoscope technology has been used to image portions of the gastrointestinal (gi) tract, particularly the small bowel. However in other gi organs, especially those having larger-lumens, the capsule may become destabilized and tumble, precluding meaningful interpretation of the acquired images.
Uti Limited Partnership
Treatment of th17 mediated inflammatory diseases
The present invention provides methods and means to reduce inflammation associated with irf-4, ap-1 and th17 mediated diseases. In particular, the invention provides methods and means to treat multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease, and psoriasis and related conditions..
Disclosed are methods for conducting diagnostic tests for the detection of the inflammatory bowel diseases, such as crohn's disease and ulcerative colitis. Also described are methods for monitoring a patient by administering tests of the present invention.
Meso Scale Technologies, Llc
Systems and methods for selectively stimulating components in, on, or near the pudendal nerve or its branches to achieve selectively physiological responses
Systems and methods selectively stimulate components of the pudendal nerve away from the sacral root to evoke desired physiologic responses in persona who lack the ability to otherwise produce these responses—e.g., maintain continence and/or produce micturition, and/or provide male/female sexuality responses, and/or provide bowel responses. The systems and methods use a multiple electrode array, or individual electrodes, placed on, in, or near the pudendal nerve.
Case Western Reserve University
The invention relates to compounds acting as selective antagonists of transient receptor potential cation channel subfamily m member 8 (trpm8), and having formula (i). Said compounds are useful in the treatment of diseases associated with activity of trpm8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exhacerbated respiratory disorders and urological disorders..
Azathioprine oral suspensions and methods of use
Compositions of azathioprine oral suspensions are disclosed. Disclosed azathioprine oral suspensions may be used to administer azathioprine to subjects such as children and geriatric patients that may have difficulty in swallowing solid dosage forms.
Professional Compounding Centers Of America
Novel triazinedione derivatives as gabab receptor modulators
The present invention provides novel compounds of formula i wherein w1, w2, w3, w4, w5, b, x1, x2, x3, x4, x5, e and l are as defined herein; invention compounds are gamma amino butyrique acid receptor-subtype b (“gabab”) positive allosteric modulators (enhancers), which are useful to provide methods of treating or preventing diseases or disorders, including treatment of anxiety, depression, epilepsy, schizophrenia, cognitive disorders, spasticity and skeletal muscle rigidity, spinal cord injury, multiple sclerosis, amyotrophic lateral sclerosis, cerebral palsy, neuropathic pain and craving associated with cocaine and nicotine, panic disorder, posttraumatic stress disorders, urge urinary incontinence, gastroesophageal reflux disease, transient lower oesophageal sphincter relaxations, functional gastrointestinal disorders and irritable bowel syndrome.. .
Addex Pharma S.a.
Treatment of inflammatory bowel disease with 6-mercaptopurine
Methods of administering a delayed release 6-mercaptopurine pharmaceutical composition to patients suffering from inflammatory bowel disease which provide for release of the 6-mercaptopurine after passage of the pharmaceutical composition through the stomach are disclosed. The methods result in significant clinical improvement despite leading to very little systemic absorption of 6-mercaptopurine and also result in very few undesirable side effects..
Teva Pharmaceutical Industries, Ltd.
Chymosin for the prevention and treatment of gastrointestinal disorders
The present invention is directed to medical or dietary treatments comprising administration of a zymogen such as chymosin or other rennins. Embodiments of the invention are directed to treating infant colic, heartburn, gastro-esophageal reflux (ger), gastro-esophageal reflux disease (gerd), irritable bowel syndrome, and recurrent abdominal pain.
Bathroom laptop device
A device for assisting with bowel movements. The device comprises a rectangular, generally flat portion.
Method of making monomethyl fumarate
Methods of making monomethyl fumarate, which can then also be used in methods of making prodrugs of monomethyl fumarate, are disclosed. Monomethyl fumarate and prodrugs of monomethyl fumarate are useful for treating neurodegenerative, inflammatory, and autoimmune diseases including multiple sclerosis, psoriasis, irritable bowel disorder, ulcerative colitis, arthritis, chronic obstructive pulmonary disease, asthma, parkinson's disease, huntington's disease, and amyotrophic lateral sclerosis..
Novel enteric combination therapy
There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, ibd-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, parkinson's disease, ms, alzheimer's disease, motor neurone disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers' diarrhoea, chronic idiopathic nausea, ibd-associated constipation and diarrhoea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, parkinson's disease, ms, alzheimer's disease, motor neurone disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment..
Therapeutic agent for inflammatory bowel disease
The present invention provides a therapeutic and/or prophylactic agent for inflammatory bowel disease and an nf-kb activation inhibitor, each of which comprises chitin nanofibers or chitosan nanofibers.. .
Method for treatment of disorders of the gastrointestinal system
There are provided novel synthetic stool preparations comprising bacteria isolated from a fecal sample from a healthy donor. The synthetic stool preparations are used for treating disorders of the gastrointestinal tract, including dysbiosis, clostridium difficile infection and recurrent clostridium difficile infection, prevention of recurrence of clostridium difficile infection, treatment of crohn's disease, ulcerative colitis, irritable bowel syndrome, inflammatory bowel disease, and diverticular disease, and treatment of food poisoning such as salmonella.
Spiroindoline derivatives as gonadotropin- releasing hormone receptor antagonists
Spiroindoline derivatives, process for their preparation and pharmaceutical compositions thereof, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially sex-hormone-related diseases in both men and women, in particularly those selected from the group of endometriosis, uterine fibroids, polycystic ovarian disease, hirsutism, precocious puberty, gonadal steroid-dependent neoplasia such as cancers of the prostate, breast and ovary, gonadotrope pituitary adenomas, sleep apnea, irritable bowel syndrome, premenstrual syndrome, benign prostatic hypertrophy, contraception and infertility (e.g., assisted reproductive therapy such as in vitro fertilization). The present application relates in particular to spiroindoline derivatives as gonadotropin-releasing hormone (gnrh) receptor antagonists..
Amine polymers for use as bile acid sequestrants
The present invention provides crosslinked amine polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritus, irritable bowel syndrome-diarrhea (ibs-d), bile acid malabsorption, and the like..
Apparatus and use in analyzing a patient's bowel
An apparatus and method are provided for use in studying a patient's bowel which combines recording and analysis of physiologic parameters and patient sensory perception. A pain input detector, a pain transducer, and a processor are provided.
Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof
And the pharmaceutical use thereof. Medicaments which comprise compounds of this type are suitable for the prevention or treatment of diverse disorders such as, for example, of respiratory disorders, cystic fibrosis disorders, acute or chronic renal disorders or bowel disorders..
Treatments for gastrointestinal disorders
The present invention provides pharmaceutical compositions and methods of treating lower gastrointestinal disorders, including inflammatory bowel disease (ibd), diverticulitis, colon cancer, an inflammatory disorder, obesity, congestive heart failure, benign prostatic hyperplasia (bph), pain, salt retention or fluid retention.. .
Uses of 4'-desferrithiocin analogs
Macular degeneration, closed head injury, stroke, irritable bowel disease, and reperfusion injury are all associated with biological injury due to reactive oxygen species, probably due to focal iron overload in many instances. The present invention provides methods and pharmaceutical compositions for treating these diseases and conditions using desferrithiocin analogs of formula (i).
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Bowel topics: Bowel Disease, Inflammatory Bowel Disease, Irritable Bowel Syndrome, Inflammation, Mercaptopurine, Probiotics, Abdominal Pain, Discomfort, Bowel Movement, Gastrointestinal, Ulcerative Colitis, Rheumatoid Arthritis, Jejunal Tube, Spring Mechanism, Small Bowel
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