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Bovine patents



      
           
This page is updated frequently with new Bovine-related patent applications. Subscribe to the Bovine RSS feed to automatically get the update: related Bovine RSS feeds. RSS updates for this page: Bovine RSS RSS


Date/App# patent app List of recent Bovine-related patents
08/21/14
20140234361
 Novel expression vectors and uses thereof patent thumbnailNovel expression vectors and uses thereof
A method for treating an hiv disease in a subject in need of said treatment, comprising administering to the subject a therapeutically effective amount of a dna vaccine comprising an expression vector and a pharmaceutically acceptable excipient, where the expression vector comprises: (a) a heterologous promoter operatively linked to a dna sequence encoding a nuclear-anchoring protein, where the nuclear-anchoring protein comprises: (i) a dna binding domain which binds to a specific dna binding sequence, and (ii) a functional domain of the bovine papilloma virus type 1 e2 protein, where the functional domain binds to a nuclear component; (b) a multimerized dna sequence that forms a binding site for the nuclear anchoring protein; and (c) at least one expression cassette comprising a dna sequence encoding a protein or peptide that stimulates an immune response specific to the protein or peptide; where the expression vector lacks an origin of replication functional in mammalian cells.. .
08/14/14
20140227267
 Bovine fusion antibodies patent thumbnailBovine fusion antibodies
Disclosed herein are immunoglobulin constructs comprising at least one immunoglobulin domain or fragment thereof; and a therapeutic polypeptide or derivative or variant thereof attached to or inserted into said immunoglobulin domain. Also provided are immunoglobulin constructs comprising a mammalian immunoglobulin heavy chain comprising at least a portion of a knob domain in the complementarity-determining region 3 (cdr3h) or fragment thereof; and a therapeutic polypeptide attached to or inserted into said knob domain of the cdr3h.
08/07/14
20140221636
 Bovine adeno-associated viral (baav) vector and uses thereof patent thumbnailBovine adeno-associated viral (baav) vector and uses thereof
The present invention provides a bovine adeno-associated virus (baav) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the baav vectors and particles..
07/31/14
20140212452
 Vaccination of animals to elicit a protective immune response against tick infestations and tick-borne pathogen transmission patent thumbnailVaccination of animals to elicit a protective immune response against tick infestations and tick-borne pathogen transmission
Two antigenic and immunogenic proteins of the cattle tick, rhipicephalus microplus, and the genes encoding these proteins, are effective for eliciting a protective immune response that controls and prevents infestations of bovines and other livestock by the tick. The proteins isolated from the cattle tick include an aquaporin protein and a tc5777 gut membrane protein.
07/24/14
20140205839
 Pure albumin and its method of preparation and detection patent thumbnailPure albumin and its method of preparation and detection
The subject of the present invention is a pure monomeric bovine serum albumin, a method of producing it characterised by the use column chromatography in resin and a method of identifying it using dynamic light scattering.. .
07/17/14
20140201857
 Hornless livestock patent thumbnailHornless livestock
Compositions and methods for making livestock with a polled allele are presented, including migrating a polled allele into a bovine species without changing other genes or chromosomal portions.. .
07/03/14
20140186456
 Tripartite bioactive composition providing anti-oxidant and anti-inflammatory effects with immune system and stem cell production enhancement patent thumbnailTripartite bioactive composition providing anti-oxidant and anti-inflammatory effects with immune system and stem cell production enhancement
The inventive tripartite composition is a combination of fucoidan, trans-resveratrol, and bovine colostrum in effective quantities, in the range of from 1:1.5:1.5 to 1:10:10 in weight percent. This composition provides antioxidant protection of cells against free radicals, strengthens the immune system, and enhances cellular function and stem cell population, thereby providing renewal and repair throughout the body.
06/19/14
20140171378
 Leucine-rich peptide compositions and methods for isolation patent thumbnailLeucine-rich peptide compositions and methods for isolation
Disclosed are compositions comprising isolated peptides having a leucine content of from about 12 to about 40 weight percent. Also disclosed is a method for isolating leucine-rich peptides from protein sources such as bovine whey and methods of use for these peptides to provide beneficial effects in a human and/or animal such as increasing blood flow, decreasing blood pressure, increasing muscle mass, improving cognitive function, improving cardiovascular function, etc..
06/19/14
20140170190
 Attenuated mannheimia haemolytica vaccines and methods of making and use patent thumbnailAttenuated mannheimia haemolytica vaccines and methods of making and use
The present invention provides attenuated m. Haemolitica strains that elicit an immune response in animal against m.
06/19/14
20140170177
 Food supplement having high immunological value, based on a protein matrix patent thumbnailFood supplement having high immunological value, based on a protein matrix
The invention relates to a food supplement having high immunological value, based on a protein matrix, i.e. A food compound with high immunological value, based on the mixture of four protein sources: i.
06/12/14
20140161935
Processed food
A processed food has an inoffensive or pleasant aroma. The aroma may be developed by including carbohydrate-rich protein sources and limiting non-nutritive acids, plasticizers, and/or artificial colorants.
06/05/14
20140155296
Methods and compositions for improved cattle longevity and milk production
A single nucleotide polymorphic site at position 10793 of the bovine pou1f1 gene is associated with improved longevity and milk product traits. Disclosed are nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods..
05/29/14
20140147834
Kit for detecting bovine leukemia virus(blv), and use thereof
A kit for detecting bovine leukemia virus (blv) according to the present invention includes: a first pcr primer being oligonucleotide including successive 20 bases or more in the base sequence denoted by seq id no: 1, the first pcr primer being oligonucleotide having 50 bases or less; and second pcr primer being including successive 20 bases or more in the base sequence denoted by seq id no: 2, the second pcr primer being oligonucleotide having 50 bases or less is included.. .
05/29/14
20140147488
Feed or food product composition
The present invention relates to a feed or food product composition which comprises a mixture of bovine colostrum, comprising bioactive components, and organic particulate matter having a size between 0.3 and 7 mm in diameter. The composition is especially adapted to deliver the mixture of bioactive bovine colostrum components to the digestive tract of a mammal..
05/29/14
20140147466
Recombinant low virulence bovine herpesvirus-1 (bohv-1) vaccine vectors
The present disclosure teaches generally in the field of vaccination and disease control in cattle and bovine animals. A recombinant bovine herpesvirus 1 (bohv-1) vaccine vector is provided for efficient control of one or more bovine pathogens such as those associated with bovine respiratory disease complex, such as bovine viral diarrhea virus (bvdv), and which ameliorates disease conditions caused thereby.
05/22/14
20140142369
Dairy cattle breeding for improved milk production traits in cattle
Nucleic acid molecules comprising a snp site at position 1296 of bovine uterine milk protein (utmp) coding sequence (seq id no: 1), which snp indicates a desirable productive life in a dairy cattle. Also disclosed are an array or a kit comprising the same, a method for detecting the snps, a method for progeny testing of cattle, and a method for selectively breeding of cattle..
05/15/14
20140134621
Compositions, methods, and systems for inferring bovine breed
Provided herein are methods to discover and use single nucleotide polymorphisms (snp) for identifying breed, or line and breed, or line composition of a bovine subject. The present invention further provides specific nucleic acid sequences, snps, and snp patterns that can be used for identifying breed or breed combinations for angus, holstein, limousin, brahman, hereford, simmental, gelbvieh, charolais and beefmaster breeds.
05/15/14
20140134144
Use of probiotic bacterial strains as a prophylactic tool against uterine infections in pregnant female ruminants
A method of treating uterine infections in a female bovine includes the step of, prior to parturition, intravaginally administering the female bovine with one or more bacterial strains such as lactobacillus sakei fua 3089, pediococcus acidilactici fua 3140, and pediococcus acidilactici fua 3138, effective for treating pathogenic microorganisms associated with postpartum infection of the uterus of female bovines.. .
04/17/14
20140105930
Bovine vaccines and methods
Methods for stimulating immune responses in a bovine animal susceptible to infection by leptospira hardjo-bovis are disclosed. In the methods, a composition of inactivated l.
04/10/14
20140100111
Seed coating hydrogels
A bio-degradeable seed coating composition for enhanced seed protection and propagation comprises a gelatin-based hydrogel formulation consisting of a naturally derived, hydrophilic protein in combination with a sulfated or non-sulfated polysaccharide. The protein is animal porcine or bovine derived while the polysaccharide is preferably a cellulose derivative such as sodium cellulose sulfate, dextran sulfate, sulfated chitosan, sulfated starch and mixtures thereof.
03/27/14
20140088175
Transduction of cells by adeno-associated virus vectors
The present invention provides methods of transcytosing barrier epithelial cells using adeno-associated virus-4 (aav4), adeno-associated virus-5 (aav5), adeno-associated virus-7 (aav7), bovine adeno-associated virus (baav), and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid across the barrier epithelia using the aav4, aav5, aav7, and baav vectors and particles..
03/27/14
20140087444
Proviral plasmids and production of recombinant adeno-associated virus
Proviral plasmids contain a modular gene expression cassette with one or a combination of (i) a wildtype 5′ aav2 itr sequence flanked by unique restriction sites that permit ready removal or replacement of said itr; (ii) a promoter flanked by unique restriction sites that permit ready removal or replacement of the entire promoter sequence; (iii) a polylinker sequence that permits insertion of a gene coding sequence without modification thereof, wherein the gene is operatively linked to, and under the regulatory control of, the aforementioned promoter; (iv) a bovine growth hormone polyadenylation sequence flanked by unique restriction sites that permit ready removal or replacement of said polya sequence; and (v) a wildtype 3′ aav2 itr sequence flanked by unique restriction sites that permit ready removal or replacement of the 3′ itr. These plasmids enable rapid manipulation of the components of the cassette, e.g., rapid mutation and/or replacement of any component, and thereby increase the efficiency of recombinant viral vector, e.g., raav, production..
03/27/14
20140087001
Pharmaceutical compositions and topical use thereof
The present invention relates to methods for the preparation of compositions comprising adipose tissue-derived secretions, for example those derived from bovine adipose tissue, and the use of such compositions in the preparation of a pharmaceutical composition for topical use. The invention also relates to the use of adipose tissue-derived secretions and pharmaceutical compositions thereof for the topical treatment of a non-inflammatory condition, for example the treatment of a skin condition, and for the stimulation of hair growth in a subject by topical application.
03/13/14
20140072670
Method for producing non-bovine chymosin and use hereof
A method of recombinantly producing a non-bovine pre-prochymosin, prochymosin or chymosin derived from ruminant species including deer species, buffalo species, antelope species, giraffe species, ovine species and caprine species; camefidae species such as came/us dromedarius; porcine species; or equ;dae species. The recombinant enzymes are used in milk coagulating compositions in cheese manufacturing based on cow's milk and milk from any animal species which are used in cheese manufacturing including camel's milk..
03/06/14
20140066514
Veterinary compositions for controlling ecto- and endoparasites in bovines, use of these compositions, use of igr substances associated with microminerals, method for controlling ecto- and endoparasites in bovines and kit
Veterinary compositions are described for controlling ecto- and endo-parasites in animals, such as bovine. The compositions contain an igr compound(s) or a benzoyl substituted urea(s) along with a mineral mix and at least one carrier..
03/06/14
20140065161
Treatment method for microbial infection
A treatment composition for treating or preventing bovine mastitis, the treatment composition characterised in that it includes at least two components which have an isoelectric point of or above substantially 6.8 and is extracted from milk, or a milk derived substance.. .
03/06/14
20140065127
Staphylococcus haemolyticus prophage phish2 endolysin is lytic for staphylococcus aureus
Methicillin-resistant (mrsa) and multi-drug resistant strains of staphylococcus aureus are becoming increasingly prevalent in both human and veterinary clinics. S.
03/06/14
20140065101
2'-branched nucleosides for treatment of viral infections
Or a pharmaceutically acceptable salt thereof, wherein r1 is defined herein, which is a 2′-branched nucleoside useful for the treatment or prevention of viral infections, particularly dengue virus, yellow fever virus, west nile virus, japanese encephalitis virus, tick-borne encephalitis virus, kunjin virus, murray valley encephalitis, st louis encephalitis, omsk hemorrhagic fever virus, bovine viral diarrhea virus, zika virus and hepatitis c virus.. .
02/20/14
20140050753
Polyionic papilloma virus-like particle (vlp) vaccines
The present invention relates to the field of vaccines. In particular, the present invention provides compositions and methods relating to virus-like particle (vlp) vaccines.
02/20/14
20140048018
Degradable animal chew toy and method of making same
A chew for a domestic animal comprises one or more sheets of a chewable bovine rawhide formed into a shape suitable for chewing by a domestic animal, wherein the one or more sheets has a mass loss of at least 45% as measured by the degradability standard test protocol. The bovine rawhide is made with a process that includes treatment with an enzyme.
02/13/14
20140045711
Single nucleotide polymorphisms associated with bull fertility
Single nucleotide polymorphic sites of the bovine map1b, ppp1r11, and ddx4 genes are associated with improved bull fertility as measured by e.g. Sire conception rates.
01/30/14
20140030778
Bacterial strain and process for the fermentative production of organic acids
The present invention relates to a novel bacterial strain designated dd1, which has the ability to produce organic acids, in particular succinic acid (sa), which was originally isolated from bovine rumen, and is capable of utilizing glycerol as a carbon source; and variant strains derived there from retaining said capability; as well as to methods of producing organic acids, in particular succinic acid by making use of said microorganism.. .
01/09/14
20140010865
Enhanced immune response in bovine species
The present invention relates to a method of immune activation which is effective for eliciting a non-antigen-specific immune response in a member of the bovine species. The method is particularly effective for protecting a member of the bovine species from infectious disease and treating animals inflicted with infectious disease..
12/19/13
20130337471
Cell identification with nanoparticles, compositions and methods related thereto
The present disclosure provides a method for identifying rare or low-abundant biological entities such as hodgkin's and reed-sternberg cells, circulating tumor cells in peripheral blood, circulating fetal cells, stem cells, somatic cells, hiv-infected t cells, bacteria or viruses in water, adenoviruses, enteroviruses, hepatitis a and e, dengue, swine flu, bovine diarrhea, and protozpa/helminthes. The method uses a suite of nanoparticle-conjugated agents to mark biological targets of interest for subsequent fluorescence imaging.
12/12/13
20130331898
Bioactive bone graft substitutes
Provided are synthetic bone graft substitutes that include bioactive glass and a carrier. Synthetic bone graft substitutes may include bioactive glass, glycerol and polyethylene glycol.
12/05/13
20130325111
Pre-assembled bioprosthetic valve and sealed conduit
A valved conduit including a bioprosthetic valve, such as a heart valve, and a tubular conduit sealed with a bioresorbable material. The bioprosthetic heart valve includes prosthetic tissue that has been treated such that the tissue may be stored dry for extended periods without degradation of functionality of the valve.
11/28/13
20130315947
Vaccination of animals to elicit a protective immune response against tick infestations and tick-borne pathogen transmission
Two antigenic and immunogenic proteins of the cattle tick, rhipicephalus microplus, and the genes encoding these proteins, are effective for eliciting a protective immune response that controls and prevents infestations of bovines and other livestock by the tick. The proteins isolated from the cattle tick include an aquaporin protein and a tc5777 gut membrane protein.
11/21/13
20130310929
Methods of conditioning sheet bioprosthetic tissue
Methods for the conditioning of bioprosthetic material employ bovine pericardial membrane. A laser directed at the fibrous surface of the membrane and moved relative thereto reduces the thickness of the membrane to a specific uniform thickness and smoothes the surface.
11/21/13
20130310372
Pharmaceutical transdermal compositions and method for treating inflammation in cattle
Novel transdermal preparations combining a non-steroidal anti-inflammatory drug (nsaid) selected from groups such as oxicams (for example, meloxicam), propionic acids (for example, ketoprofen) and anthranilic acids (for example, tolfenamic acid), are disclosed. Methods for using and administering such preparation in the treatment of inflammatory conditions in bovines are also disclosed..
11/07/13
20130295687
Novel method of isolation of tlr4 from cell lysates of mononuclear cells
A novel method of isolation of tlr4 from cell lysates of mononuclear cells is provided. The method includes: collecting bovine adult filarial parasites (setaria digitata); preparing aqueous extracts of setaria digitata (fag) to produce affinity purified filarial glycoprotein (agw); isolating human pbmcs from heparinised venous blood samples; subjecting the isolated human pbmcs to the step of incubation to produce pbmc lysates; coupling the said agw with cnbr activated sepharose; and loading the agw coupled with sepharose and pbmc lysates to an affinity purification column to isolate the receptor recognizing agw and detecting the reactivity of anti-receptor antibodies and anti-human tlr4 antibodies to the affinity purified receptor using peroxidase conjugated anti-rabbit igg (in solidphase assay)..
11/07/13
20130295167
Enhanced immune response in bovine species
The present invention relates to a method of immune activation which is effective for eliciting a non-antigen-specific immune response in a member of the bovine species. The method is particularly effective for protecting a member of the bovine species from infectious disease and treating animals inflicted with infectious disease..
11/07/13
20130291480
Engineered molded fiberboard panels
A fiberboard panel is formed from at least one corrugated sheet of molded cellulose fiber material formed from a mixture of at least two different cellulose fibers, one of the fibers comprising bovine processed fiber (bpf). The panel has opposite first and second faces and is formed with alternating ribs and grooves.
10/31/13
20130289403
Method and apparatus to reduce the number of sperm used in artificial insemination of cattle
The present artificial insemination instrument may include a single use, hollow, elongate, metal pipette and a single disposable syringe that is not toxic to bovine sperm. The apparatus is used with any type of diluent that is not toxic to bovine sperm.
10/24/13
20130281442
Compounds for treatment of bovine mastitis
Described herein are methods of treating mastitis in female mammals, e.g., cows, wherein the methods may include administering to mammals in need thereof compounds disclosed herein.. .
10/24/13
20130280353
Phytotherapic pharmaceutical combination of lippia salviifolia and lippia sidoides, phytotherapic pharmaceutical composition, process for preparing a phytotherapic pharmaceutical composition and veterinary uses thereof
Phytotherapic pharmaceutical forms with antimicrobial activity, comprising a mixture of essential oils of lippia salvifolia and lippia sidoides, appropriate for the treatment of mastitis, notably bovine mastitis, and to a process of preparation of said compositions and their veterinary uses.. .
10/24/13
20130280294
Bovine viral diarrhea virus type 1b vaccine compositions and methods
Disclosed are immunogenic compositions, and methods for their use in the formulation and administration of therapeutic and prophylactic pharmaceutical agents. In particular, the invention provides immunogenic compositions and methods for preventing, treating, managing, and/or ameliorating a viral or microbial infection, or one or more symptoms thereof, including, for example, those infections giving rise to shipping fever, bovine respiratory disease complex, and/or bovine viral diarrhea, particularly in susceptible or infected animals..
10/10/13
20130267770
Genetic testing for improved cattle fertility
Arrays of nucleic acid molecules, kits, methods of genotyping and marker assisted bovine breeding methods based on novel snps on genes of the bovine transforming growth factor-β (tgf-β) signaling pathway for improved bovine fertilization rate. The methods and compositions of the present invention are related to snps in the dna-binding protein inhibitor 3 (id3) gene, and in the bone morphogenetic protein 4 (bmp4) gene corresponding to position 2702 of seq id no: 2.
10/10/13
20130267008
Freezing medium composition for cryopreserving amniotic fluid-derived stem cells and a method for cryopreserving the same
Provided are to a freezing medium composition for cryopreserving amniotic fluid-derived stem cells, which has a lower concentration of me2so and eliminates fetal bovine serum and at the same time does not induce cryoinjury to fluid-derived stem cells and makes it possible to cryopreserve fluid-derived stem cells for a prolonged time using trehalose, sucrose and catalase, and a method for cryopreserving the same. According to the present invention, afscs can be cryopreserved with 1/4 the standard me2so concentration with the addition of disaccharides, antioxidants and caspase inhibitors.
10/10/13
20130266934
Compositions and methods for identifying and differentiating viral components of multivalent shipping fever vaccines
Disclosed are methods and compositions for identifying viral-specific polynucleotide sequences in a biological sample, and particularly in samples of veterinary origin. Also disclosed are oligonucleotide primer pairs, as well as labeled oligonucleotide detection probes useful in detecting the presence of one or more particular species, strains, types, or subtypes of one or more mammalian pathogens of viral origin, as well as systems, diagnostic kits and articles of manufacture comprising virus-specific primers and labeled detection probes, including those useful in identifying viral components of a multivalent vaccine, and quantitating the potency of particular attenuated, live viruses that comprise a livestock vaccine.
10/10/13
20130266686
Method for desalting animal tissue
The present invention relates to a method for desalting tissue originating from animals. In particular, the present invention provides a method for desalting mucosa tissue, notably mucosa tissue originating from bovine or porcine.
09/19/13
20130245100
Polynucleotide for use in treatment of influenza a virus induced diseases, encoding modified mx protein, said modified mx protein, and a transgenic animal expressing gene encoding modified mx protein
A method can be used for treating or reducing likelihood of an influenza a virus-induced disease in a mammal. The method includes administering a polynucleotide to the mammal.
09/19/13
20130243832
Poly(vinyl benzoate) nanoparticles for molecular delivery
The present invention comprises poly(vinyl benzoate) nanoparticle suspensions as molecular carriers. These nanoparticles can be formed by nanoprecipitation of poly(vinyl benzoate) in water using pluronic f68 as surfactant, to create spherical nanostructures measuring about 200-250 nm in diameter which are stable in phosphate buffer and blood serum, and only slowly degrade in the presence of esterases.
09/12/13
20130236957
Expression vector and methods of producing high levels of proteins
E) a bovine growth hormone polyadenylation sequence or a functional variant thereof.. .
08/29/13
20130224862
Coatings and culture media for promoting neurogenesis in adipose tissue derived stem cells
Provided herein are coatings for stem cell cultureware comprising poly-l-ornithine and bovine fibronectin and methods for preparing coated stem cultureware comprising contacting cultureware with poly-l-ornithine and contacting the cultureware with bovine fibronectin. Also provided are stem cell culture media comprising epidermal growth factor, beta-fibroblast growth factor and n2 supplement..
08/22/13
20130217018
Methods and systems for inferring bovine traits
Methods, compositions, and systems are provided for managing bovine subjects in order to maximize their individual potential performance and edible meat value, and to maximize profits obtained in marketing the bovine subjects. The methods and systems draw an inference of a trait of a bovine subject by determining the nucleotide occurrence of at least one bovine snp that is identified herein as being associated with the trait.
08/22/13
20130216578
Recombinant trypanosoma theileri parasite
The present invention relates to the field of the veterinary medicine of bovine animals. In particular the invention relates to a recombinant trypanosoma theileri parasite, preferably comprising a heterologous nucleic acid sequence that is capable of encoding a protein for instance an antigen, a cytokine, a hormone, an antimicrobial protein, or an antibody.
08/15/13
20130211186
Feeder-free method for culture of bovine and porcine spermatogonial stem cells
The present invention relates to the production and culture of undifferentiated spermatogonial stem cells that can be maintained long term and are feeder free. The resultant feeder-free populations can be used in any of a number of protocols including the generation of progeny bulls.
08/08/13
20130203871
Fuidi herd management schema
The invention is a herd management schema based upon the inventor's analysis of the natural history of bovine infection due to mycobacterium avium subspecies paratuberculosis (map) and related genomic variants and upon the ability of two distinct map elisa tests to sequentially or in parallel determine prior and current map infection and evidence of active mycobacterium replication. Interpretation of the test results are integrated into sequential directives designed to enhance productive retention of infected animals as well as identify animals not previously infected.
08/01/13
20130196356
Assay for prions
The invention relates to a method for detection of abnormal prp in a sample of blood or urine, said method comprising: (a) diluting the sample with buffer to comprise final concentrations of (i) 10 mm to 500 mm buffer agent; (ii) 1% to 10% w/v bovine serum albumin; and (iii) 1% to 8% w/v chaps; (b) adding steel particles and incubating to allow prp binding; (c) washing the steel particles to remove diluted sample; and (d) detecting abnormal prp captured on the steel particles using antibody capable of binding said abnormal prp. The invention also provides compositions and kits..
08/01/13
20130195892
Bvdv vaccine
The present invention relates to bvd virus and to its uses, to vaccines and combination vaccines comprising such a virus, their use as a medicament, their use in the treatment of bovine viral diarrhoea and to methods for the preparation of such vaccines.. .
08/01/13
20130195803
Bovine milk oligosaccharides
Oligosaccharides from bovine milk, whey and dairy products, and methods of producing bovine milk oligosaccharides are provided.. .
07/25/13
20130191098
Methods and systems for simulations of complex biological networks using gene expression indexing in computational models
A method has been developed for using genome-wide transcription profile (i.e., gene-expression level) values to derive a gene expression index used as a kinetic value for every biological reaction and process assigned to each and every gene. This kinetic value is used in computational biology programs, i.e., mathematical models integrating genome, transcriptome, proteome, reactome, fluxome, metabolome, physiome, and phenome, in any combination, for simulations or theoretical systematic analyses of all life forms.
07/11/13
20130177641
Compositions and methods for delivery of high-affinity oxygen binding agents to tumors
While tumor hypoxia is recognized as a key barrier to effective chemo and radiation therapy of solid tumor malignancies, and an important biological mediator of more aggressive tumor phenotype and behavior for over 50 years, prior attempts to improve tumor oxygenation have relied on increasing the total amount of oxygen bound to each molecule of natural hemoglobin (e.g. Through hyperbaric oxygen treatments), increasing the ease of release of oxygen from hemoglobin (through the introduction of exogenous allosteric small molecules), or increasing the total amount of oxygen in the body by injecting perfluorocarbon emulsions, or polymerized or pegylated compositions of natural human or bovine hemoglobin.
07/04/13
20130172262
Compound and method for treatment of alzheimer's disease and familial dementia
An isolated protein is provided for use in treatment of a condition selected from the group consisting of alzheimer's disease, familial danish dementia and familial british dementia in a mammal, including man. The isolated protein is selected from the group consisting of proteins comprising an amino acid sequence having at least 70% identity to residues 90-236 of bri2 from human; and proteins comprising an amino acid sequence having at least 70% identity to any one of the brichos domains of bri2 from human, chimpanzee, bovine, pig, mouse and rat..
07/04/13
20130172241
Method for processing prolamin-containing feed for a ruminant animal to potentiate milk production or conception
Composition and method for processing prolamin-containing feed source into a low-vitreous gelatinous feedstuff. The feedstuff is fed to ruminant animals for the purpose of potentiating either milk production and/or conception.


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Bovine topics: Nucleotide, Stem Cells, Polynucleotide, Antimicrobial, Growth Factor, Nucleic Acid, Insemination, Disposable Syringe, Artificial Insemination, Immunogenic, Prophylactic, Respiratory Disease, Respiratory, Essential Oil, Recombinant

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