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Blood patents

      

This page is updated frequently with new Blood-related patent applications.

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new patent Molecular characterization of circulating tumor cells
The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.. .
Menarini Silicon Biosystems, Inc.


new patent Method for evaluating coagulation ability of blood specimen, and reagent, reagent kit and device to be used therein
The present invention relates to a method for evaluating coagulability of a blood specimen obtained from a subject to whom a substance having a coagulation factor viii-substituting activity is administered. The present invention also relates to a reagent for blood coagulation analysis, a reagent kit for blood coagulation analysis, and an apparatus for blood coagulation analysis.
Sysmex Corporation


new patent Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge
The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles.
Angle North America, Inc.


new patent Biosensor system, sensor chip, and measuring analyte concentration in blood sample
The present invention provides a biosensor system that can prevent a measurement error caused by the temperature of the environment in use from occurring. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 that is insertable into and removable from the measuring instrument 101 and into which a blood sample is introduced.
Panasonic Healthcare Holdings Co., Ltd.


new patent Method for production of heparin and heparan sulfate
This present disclosure relates to a method of producing a proteoglycan having anticoagulant activity, comprising of and providing a cell transfected with a recombinant nucleic acid encoding a core protein having one or more glycosaminoglycan attachment sites; and incubating the cell under conditions to promote the production of a proteoglycan comprising the core protein linked to heparin and/or hs and optionally other glycosaminoglycan chains, and to heparin or heparan sulphate isolated from such proteoglycans that have significant anti-coagulant activity. The invention also relates to a recombinant proteoglycan comprising a core protein and heparin and/or heparan sulfate, to a cell capable of producing a proteoglycan comprising the core protein and heparin and/or heparan sulfate, and to a method of treating or preventing blood coagulation, or a condition associated with blood coagulation, using the recombinant proteoglycan comprising a core protein and heparin and/or heparan sulfate and/or the heparin and/or heparan sulfate isolated from such proteoglycans..
Newsouth Innovations Pty Limited


new patent Substituted bridged urea analogs as sirtuin modulators
Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
Glaxosmithkline Llc


new patent Assembly with a guide wire and a fixator for attaching to a blood vessel
A fixator assembly comprising a fixator for fixing inside a blood vessel, the fixator being able to slide proximally along a guide wire. The assembly comprising means for preventing the fixator from moving distally of the preventing means.
Endovascular Development Ab


new patent Method and system for closed-loop control of an artificial pancreas
Methods and systems for controlling an insulin pump in response to glucose measurements are responsive to a base insulin delivery profile and a temporary insulin delivery profile. These can be used, e.g., to control blood glucose level of a subject using a continuous glucose monitor and an insulin infusion pump.
Animas Corporation


new patent Femoral arterial cannula capable of guiding bidirectional perfusion flow
The present invention relates to a cannula for femoral arterial bidirectional (a heart direction and a distal lower extremity direction) perfusion. The cannula, which has a cannula tube to be inserted into a blood vessel of the femoral artery, includes a perfusion guide channel formed as a concave part from a predetermined portion of an inner circumferential surface at an end of the cannula tube to the opposite end thereof in a length direction and further includes a through-hole provided at a boundary portion between the perfusion guide channel and the cannula tube in an end direction of the cannula tube, or includes a through-hole provided in a predetermined portion of to an inner circumferential surface of an end of the cannula tube and a guide cover provided at an upper portion of the through-hole to cover the upper portion of the through-hole and guide perfusion.
Samsung Life Public Welfare Foundation


new patent Magnetic filtration devices and methods related thereto
In vivo and ex vivo positionable magnetic filtration devices are provided that magnetically filter one or more therapeutic agents conjugated to a magnetic particle in blood flowing in a blood vessel.. .
The Regents Of The University Of California


new patent

Adaptive peritoneal dialysis intra-session adjustments for overall session optimization

The invention relates to systems and methods for adjusting one or more dialysis parameters for delivering a peritoneal dialysis cycle to a patient based on patient or system parameters. The systems and methods include various sensors, flow paths, and processors to adjust the dialysis parameters used to deliver peritoneal dialysis therapy, for a specific peritoneal dialysis cycle.
Medtronic, Inc.

new patent

Compounds for improving the half-life of von willebrand factor

The invention relates to a compound, preferably an antibody, capable of binding to the receptor protein clec10a for use in the treatment of a blood coagulation disorder.. .
Csl Behring Recombinant Facility Ag

new patent

Injectable microtissue systems, devices, and methods

Spheroid microtissues that can mimic native tissue-like structure and function, spheroid production methods that are high-throughput, suitable for efficient production, maintainable over long-term culture, and/or offer repeatable control over size distribution. Spheroids that have blood vessels, including spheroids with functional, blood-perfused vascular networks upon injection in vivo.
The Trustees Of Columbia University In The City Of New York

new patent

Treatment of retinopathy of prematurity (rop)

Disclosed herein are methods of treating retinopathy of prematurity (rop) in a premature and/or low birth weight infant in need thereof, comprising administering to the infant an effective amount of a compound represented by structural formula i, structural formula ia or structural formula ii described herein, or a pharmaceutically acceptable salt thereof. Also disclosed herein are methods of inhibiting the destruction of retinal blood vessels in a premature and/or low birth weight infant in need thereof, comprising administering to the infant an effective amount of a compound represented by structural formula i, structural formula ia or structural formula ii, or a pharmaceutically acceptable salt thereof.
The Cleveland Clinic Foundation

new patent

Perivascular drug delivery system

The present technology provide compositions that are drug delivery systems for the sustained release of anti-stenotic drugs for the treatment and prevention of occlusion of blood vessels, particularly after perivascular surgery. The compositions include a hydrogel, unimolecular micelles dispersed within the hydrogel, and an effective amount of anti-stenotic drug dispersed within the unimolecular micelle.
Wisconsin Alumni Research Foundation

new patent

Multi-element bioresorbable intravascular stent

A multi-element, bioresorbable, vascular stent may be used to maintain or enhance patency of a blood vessel. The stent may be used in peripheral blood vessels, which may be long and/or tortuous.
Efemoral Medical Llc

new patent

Methods and devices to remove thromboembolic material from blood vessels

A guard device for removal of thromboembolic material from a blood vessel includes a placement catheter having at least one axial lumen, a shield device having a pusher wire with an expandable braid assembly attached to its distal end and deliverable through the lumen of the placement catheter. The expandable braid assembly has a distal end with a distal tip at the distal end, where the distal tip prevents the distal end of the expandable braid assembly from fully expanding when deployed from the placement catheter.

new patent

Blood clot aspiration catheter

A blood clot aspiration catheter includes an aspiration/flushing lumen having a distal portion that is insertable into a blood vessel of a patient, an aspiration device configured to create an aspiration phase to aspirate clot and blood into the aspiration/flushing lumen and a flushing phase to flush non-clotted blood from the aspiration/flushing lumen, a one-way valve configured to allow clot and blood to flow through the aspiration/flushing lumen during the aspiration phase and to block flow during the flushing phase, and filter valves configured to filter non-clotted blood to be flushed from the aspiration/flushing lumen.. .

new patent

Surgical clamping devices

Clamping devices for occluding a blood vessel comprise a pair of jaws for receiving the blood vessel therebetween, one or more inflatable membranes within the jaws and at least one handle coupled to the pair of jaws via a hollow arm. The at least one handle comprises an actuator coupled to the one or more inflatable membranes via the hollow arm for inflating the one or more inflatable membranes to occlude the blood vessel..
Vascular Devices Pty. Ltd.

new patent

Medical-information processing apparatus and x-ray ct apparatus

A medical-information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry acquires medical image data that is obtained during imaging on the subject in a resting state in the time phase where the relationship between the volume of blood flow and the pressure in a blood vessel in the cardiac cycle of the subject indicates a proportional relationship.
Toshiba Medical Systems Corporation

new patent

Sensors for prosthetic heart devices

Prosthetic heart devices may be implanted into the heart with a sensor coupled to the device, the sensor being configured to measure physiological data, such as blood pressure, in the heart. Devices that may employ such sensors include prosthetic heart valves and occlusion devices, although sensor systems may be deployed in the heart separate from other implantable devices.
St. Jude Medical, Cardiology Division, Inc.

new patent

Biological signal detecting device, biological signal processing device, and blood pressure measuring system

A radio wave transmitted from an oscillation source through a first antenna is received each by a second antenna and a third antenna, and a synchronous detection is performed. Variation in impedance of a subject, i.e., variation in impedance of a human body, causes an effect equivalent to performing amplitude modulation with respect to an unmodulated radio wave, and gain fluctuation of a received radio wave caused due to the existence of the human body is cancelled out by a differential amplifier..
Ai Technology Inc.

new patent

System and measuring vital signs

A portable wearable computing device configured to continuously obtain data indicative of a patient's vital signs is disclosed. The portable wearable computing device includes a temperature sensor configured to obtain data indicative of body temperature of the patient.
Pelletric Llc

new patent

Body-worn pulse oximeter

The invention provides a body-worn system that continuously measures pulse oximetry and blood pressure, along with motion, posture, and activity level, from an ambulatory patient. The system features an oximetry probe that comfortably clips to the base of the patient's thumb, thereby freeing up their fingers for conventional activities in a hospital, such as reading and eating.
Sotera Wireless, Inc.

new patent

Apparatus and providing a control signal for a blood pressure measurement device

The present invention relates to an apparatus (18) for providing a control signal for a blood pressure measurement device, comprising: an input interface (24) for obtaining a health state parameter being indicative of a health state of a patient (12); a processing unit (28) for determining one or more operation settings of a blood pressure measurement device (14) based on the health state parameter, said one or more operation settings including a parameter that can be adjusted at the blood pressure measurement device (14) when conducting a blood pressure measurement with the device and that affects a precision of said blood pressure measurement and a patient comfort resulting from said blood pressure measurement; and a control interface (30) for providing a control signal for a blood pressure measurement device (14) to perform a blood pressure measurement based on said one or more operation settings. The present invention further relates to a corresponding method.
Koninklijke Philips N.v.

new patent

Biological information measuring apparatus and biological information measuring method

A biological information measuring apparatus according to an embodiment includes a calculating unit and a measuring unit. The calculating unit is configured to calculate information related to a pulse wave of a subject, on the basis of luminance information of a picture signal of the subject.
Tohoku University

Methods of obtaining geometry from images

In one aspect, a method of detecting at least on feature associated with a blood vessel in at least one image of at least one blood vessel using a matched filter adapted to respond to the at least one feature is provided. The method comprises applying a scale detection filter to selected voxels in the at least one image to determine a scale for the matched filter at each of the selected voxels, determining an orientation for the matched filter at each of the selected voxels, wherein determining the orientation is assisted by using the scale determined at each of the selected voxels, applying the matched filter at each of the selected voxels at the scale and the orientation determined at each of the selected voxels to obtain a filter response at each of the selected voxels, and analyzing the filter response at each of the selected voxels to determine if the respective voxel corresponds to the at least one feature..
Bio-tree Systems, Inc.

Methods for treating refractory anemia with ringed sideroblasts

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
Acceleron Pharma Inc.

Artificial lung and manufacturing artificial lung

An artificial lung is provided having a plurality of porous hollow fiber membranes for gas exchange, in which the hollow fiber membranes have outer surfaces, inner surfaces forming lumens, and opening portions through which the outer surfaces communicate with the inner surfaces, any one of the outer surfaces and the inner surfaces is coated with a colloidal solution of an antithrombotic material containing a polymer as a main component, and an average particle size of the colloid is at least 1.5 times a diameter of the opening portions of the hollow fiber membranes. An artificial lung is provided that can effectively suppress leakage of blood plasma components after blood circulation (blood plasma leakage)..
Terumo Kabushiki Kaisha

Methods for treating metabolic disorders using fgf

The method provides methods and compositions for treating metabolic disorders such as impaired glucose tolerance, elevated blood glucose, insulin resistance, dyslipidemia, obesity, and fatty liver.. .
Salk Institute For Biological Studies

Expandable scaffold with cutting elements mounted thereto

A medical device assembly for incising a stenosis in a blood vessel which includes an incising device, a tubular sheath, and a catheter having an inflatable balloon mounted thereon. The incising device includes a self-expanding scaffold having a plurality of cutting elements projecting radially outward therefrom, and an elongate member extending proximally from the self-expanding scaffold to be manipulated by a user.
Boston Scientific Scimed, Inc.

Evaluating arterial pressure, vasomotor activity and their response to diagnostic tests

Method and system for evaluating arterial pressure waves, vascular properties, as well as for diagnostic, physiological and pharmacological testing using various combinations of the following data acquisition and processing steps (some of the steps are optional): 1. Perturbing arterial pressure from its steady state.

System and non-invasive measurement of pressure inside a body including intravascular blood pressure

A device system and method for the non-invasive ultrasound measurement of the intravascular blood pressure is presented, wherein the blood pressure measurements are performed by means of the registration of the distances changes between the surface of the active piezoelectric transducer radiating an ultrasound beam into the localization area of the blood vessel or the heart chamber and the surface elements of the passive ultrasound beam reflector implanted into the blood vessel or the heart chamber. The invention is applicable to any medium transparent for ultrasound waves with the need to measure pressure changes of the liquid..
Pi-harvest Holding Ag

Signal analyzer system for monitoring bio-media, analysis of motion-induced signal modulation

According to one configuration, a system includes sensor hardware and signal processor resource to monitor and analyze bio-media (such as blood and/or other matter) of a person under test. During operation, the sensor hardware monitors the bio-media of the person under test and produces an output.
Analog Devices, Inc.

Cuffless blood pressure measurement using handheld device

A method for determining blood pressure is disclosed. The method comprises determining a plurality of heart sounds using a microphone of a handheld device and determining a pulse wave using a camera of the handheld device.

Blood glucose management

This disclosure provides equipment and processes for blood glucose management. Embodiments may comprise a lancet device that includes a base that supports a lancet and a cover.
Pops! Diabetes Care, Inc.

Dermatologically non-abrasive blood testing using an interferometry optical design

An apparatus, method and system for dermatologically noninvasive testing for blood sugar concentration using an interferometry optical design. The present apparatus, method and system are used to measure the optical properties of blood, without puncturing the skin or drawing blood samples.
The United States Of America As Represented By The Secretary Of The Navy

Fully automatic fecal occoult blood detecting analyzer

The present invention provides a fully automatic fecal occult blood detecting analyzer, which is used to detect a sample box (30). The sample box (30) includes a transparent sleeve and a feces collector and test strips provided in the transparent sleeve.
W.h.p.m. Bioresearch And Technology Co., Ltd.

Aptamers and sensing technology used for detection of glycated hemoglobin in whole blood

High affinity dna aptamers seq id#1-8 for hba1c and thb were successfully selected using selex after 11 rounds of selection. The tested aptamers bind to hba1c with dissociation constants in the nanomolar range with the highest affinity aptamer, seq id#6, exhibiting a kd of 2.8 nm.
Alfaisal University

Platelet test chip

Disclosed is a platelet-testing chip. The platelet-testing chip includes a plurality of sample chambers storing blood samples, stirrers provided in the sample chambers to apply shearing force to the blood samples, a plurality of waste sample chambers provided so as to correspond to the plurality of the sample chambers, microchannels, through which the sample chambers and the waste sample chambers corresponding to each other are independently connected to thus form paths through which the blood samples flow from the sample chambers to the corresponding waste sample chambers, and microbeads which are received in one or more of the plurality of the sample chambers and which are coated with a reagent for activating platelets on an outer surface thereof.
Korea University Research And Business Foundation

Blood-based gene detection of non-small cell lung cancer

The present invention provides a method for early detection of non-small cell lung cancer based on the abundance of rnas from blood samples as well as diagnostic tools such as kits and arrays suitable for such method.. .
Universitat Zu Koln

Method and apparatus relating to treatment of a blood sample for sequencing of circulating tumour cells

A method of detecting mutations in a ctc genome that uses a negative selection step to remove a proportion of non-ctcs from a blood sample. The negative selection step is followed by extraction of the dna from the remaining enriched ctcs and then by dilution of the dna to a very low concentration and preparing and sequencing two or more replicates of the final dilution..
Prokyma Technologies Limited

Methods for producing modified red blood cell compositions, compositions and uses thereof

The present invention encompasses methods for generating jak2-modified cultured red blood cells (modified crbcs) expressing a mutant janus kinase 2 peptide, jak2-modified crbcs as a composition of matter, and methods for using the generated jak2-modified crbcs.. .

Novel antibody binding to tfpi and composition comprising the same

The present invention relates to an antibody that binds specifically to a tissue factor pathway inhibitor (tfpi), a nucleic acid encoding the antibody, a vector comprising the nucleic acid, a host cell transformed with the vector, a method for producing the antibody, and a pharmaceutical composition for treating hemophilia, which comprises the antibody as an active ingredient. The antibody of the present invention, which binds specifically to tfpi, can activate the extrinsic pathway of blood coagulation by inhibiting tfpi.
Mogam Institute For Biomedical Research

Methods of detecting cancer

A method of detecting the presence of glioblastomas and/or recurrent glioblastomas in a subject in need thereof includes isolating cd14+ cells from a blood sample of the subject and determining the ratio of isolated cd14+ cells expressing low levels of hla-dr to isolated cd14+ cells expressing vnn2, wherein the subject has increased risk of glioblastomas or recurrent glioblastoma if the ratio of isolated cd14+ cells expressing low levels of hla-dr to isolated cd14+ cells expressing vnn2 is greater than about 2.. .
Case Western Reserve University

Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto

Pyrazole derivatives of formula ia and pharmaceutical compositions thereof that modulate the activity of the pgi2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (pah) and related disorders; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack; angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (sle); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (copd)..
Arena Pharmaceuticals, Inc.

Blood samples transport system

A method of transporting blood samples without using a capsule, in a tube system with an internal diameter that is greater than the external diameter of the applied blood samples and lesser than the lengths of the applied blood samples, the method including at least the following steps: •a: a blood sample (8) with an external diameter in the range Ø12 mm to Ø18 mm and with a length in the range from 80 mm to 110 mm is introduced in a tube system (1) that includes a dispatch station (3) and a receiver station (4), •a1: the physical dimensions of the blood sample (8) is checked and it is ensured that the blood sample (8) fits the tube system, •b: the blood sample (8) is dispatched from the dispatch station (3) by means of dispatching air.. .
Blak & Sørensen Aps

Axial flow pump with multi-grooved rotor

An axial-flow blood pump for pumping blood includes a substantially cylindrical outer enclosure. A tubular housing concentric with and located within the outer enclosure has at one end an inlet and at an opposite end an outlet.
Heartware, Inc.

Compositions and methods for regulating blood pressure

Both purinergic signaling through nucleotides such as atp and noradrenergic signaling through molecules such as norepinephrine regulate vascular tone and blood pressure. Pannexin1 (panx1), which forms large-pore, atp-releasing channels, is present in vascular smooth muscle cells in peripheral blood vessels and participates in noradrenergic responses.
University Of Virginia Patent Foundation

Methods and compositions for treatment of penile defects

Compositions for use in treating penile defects, including erectile dysfunction and peyronie's disease. Compositions include penile stem cells and isolated penile stem cells substantially free of red blood cells, additives such as amnion, amniotic fluid, extracellular matrix components, growth factors, anti-inflammatories, antioxidants, wound healing agents, and collagenases.

Use of biocompatible microdroplets for the treatment of atherosclerosis, heart disease and stroke

A pharmacologically acceptable emulsion of biocompatible solvent microdroplets is provided for treating atherosclerosis, heart disease and stroke. Intravenous administration of the biocompatible solvent microdroplets enables the microdroplets to bind and dissolve free cholesterol, cholesterol esters or other fatty compounds within the plaque.

Unitary endoscopic vessel harvesting devices

Unitary endoscopic vessel harvesting devices are disclosed. In some embodiments, such devices may comprise an elongated body having a proximal end and a distal end.
Saphena Medical, Inc.

Systems and methods for intravascular obstruction removal

Intraluminal devices and methods for removing an obstruction from a blood vessel using an intraluminal device are provided. The intraluminal device can include a flexible shaft and an expandable wire mesh structure extending from the flexible shaft, the wire mesh structure including at least one first expandable section having a first wire arrangement pattern and at least one second expandable section having a second wire arrangement pattern different from the first wire arrangement pattern.
Rapid Medical Ltd.

Apparatus for an adjustable radial and ulnar compression wristband

An adjustable radial and ulnar vascular compression wristband assists in achieving partial or full occlusion of a blood vessel when applied to a patient's wrist during or following a medical procedure. At least two adjustably inflatable non-adjacent balloons on the wristband apply preferential compression to portions of the circumference of the wrist, including in particular those portions overlying the ulnar and radial arteries..
Semler Technologies, Inc.

Embolization particulates for occluding a blood vessel

Injectable embolization particulates (e.g., particles, microstructures, beads) employed in embolization procedures, for facilitating blood vessel occlusion. Exemplary embolization particulates for occluding a blood vessel include a plurality of embolization beads, each bead having a plurality of outwardly protruding portions, wherein, upon a first one and a second one of the beads accumulating against a boundary of the blood vessel, protruding portions of the first bead are configured to intermesh with protruding portions of the second bead, so as to occlude the blood vessel.
Accurate Medical Therapeutics Ltd.

Early allergy detection, notification and management systems and methods

A watch-like early allergy detection, notification and management system is equipped with a motion detector as well as one or more physiological sensors to measure heart rate, skin color change, skin galvanic response, oxygen saturation and blood pressure to detect early symptoms of an allergic reaction. False alarms are reduced by simultaneously measuring ambient temperature and physical activity of the subject.

Blood sampling system and method

This disclosure relates to a system and method for drawing blood from a user by skin puncture instead of venous puncture and storing it for analysis. The system includes a receptacle configured to engage an area of skin of the user at a blood draw location and store blood drawn from the user; a lancet device disposed within the receptacle configured to puncture the skin of the user at the blood draw location; a vacuum device configured to reduce a pressure within the receptacle such that the skin at the blood draw location is drawn into the receptacle before the lancet device punctures the skin, and to enhance blood flow while blood is drawn from the user; and a housing configured to house the receptacle, the lancet device, and the vacuum device.
Invitae Corporation

Blood analyzer and blood analyzing method

Disclosed is a blood analyzer that includes: a sample preparation unit configured to mix a blood specimen and a fluorescent dye for staining nucleic acid to prepare a measurement sample; a light receiver configured to receive fluorescence and scattered light that are generated by light being applied to the measurement sample prepared by the sample preparation unit; and a controller programmed to determine whether or not infection with plasmodium has occurred, on the basis of a value representing variation of a distribution of first particles in a range where single-ring form of red blood cells appear, the range where single-ring form of red blood cells appear being identified according to fluorescence intensities and scattered light intensities obtained by processing of signals from the light receiver.. .
Sysmex Corporation

An extraction reagent of immunosuppressant drug for immunoassays

The disclosure provides a reagent for extracting immunosuppressant drugs from whole blood sample for immunoassay. The extraction reagent comprises protein denaturant, proteolytic enzyme, surfactant and ph buffer.
Shanghai Inzex Biotechnology Co.,ltd.

System for measuring total hemoglobin in blood and doing the same

A system can be used for determining a total hemoglobin concentration in a blood sample. The system has a strip that has a capillary channel having an entrance and a vent.

Endonuclease targeting blood coagulation factor viii gene and composition for treating hemophilia comprising same

The present invention provides a method for inducing an inversion of normal blood coagulation factor viii (f8) gene, a method for correcting an inversion of blood coagulation factor viii gene in which the inversion has occurred, and a hemophilia a patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the f8 gene, which is responsible for the majority of severe hemophilia a, and thereby may be effectively used for studying the development mechanism of hemophilia a and as a research tool for screening therapeutic agents.
Institute For Basic Science

Nutritional approach to the control of anemia, diabetes and other diseases or conditions and prevention of associated comorbid states with the use of ergothioneine

Nutritional products, compositions, pharmaceutical preparations and methods of use are disclosed for the prevention, suppression and treatment of anemia and/or diabetes and its various associated comorbidities. Uses of ergothioneine to neutralize free radicals and/or cytokines, reduce oxidative stress, prevent inflammation, stimulate red blood cell production with increased levels of hemoglobin, and/or stabilize iron in its normal 2+ charge for proper oxygen binding and carrying are further disclosed.
Entia Biosciences, Inc.

Naming of kh1 through kh55 good healthy cells synthesizes the kh1 through kh55 proteins

The present invention provides purified blood plasma products from fraction ii+iii containing proteins at concentrations useful for the treatment of various diseases and infections including hepatitis b virus. Methods of manufacture and treatment are also provided.
Rare Antibody Antigen Supply, Inc.

Modified blood clots

The present invention provides methods for preparing modified blood clots comprising removal of the cellular content of the blood clots. The invention further provides uses of the modified blood clots as therapeutic agents and as delivery vehicles for cells, bio-molecules and other agents..
Nayacure Therapeutics Ltd.

Proton-binding polymers for oral administration

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood ph in an animal, including a human..
Tricida, Inc.

Compositions comprising beta-hydroxybutyric acid and salt, and methods of using the same

β-hydroxybutyric acid in combination with β-hydroxybutyrate salts are useful to induce ketosis, achieving blood ketone levels of (0.5-6.0 mmol/l), with or without dietary restriction, and without inducing harmfully high mineral loads in the blood. The combination of β-hydroxybutyric acid and salt results in substantial improvements in metabolic biomarkers related to insulin resistance, diabetes, weight loss, and physical performance & endurance in a short period of time.
Savind, Inc.

Systems and methods for crossing and treating an occlusion

A system is provided for crossing an occlusion within a blood vessel or cylindrical body cavity. The system includes a guide catheter and a catheter device.
Xablecath Inc.

Method and clamping tissue layers and occluding tubular body structures

Apparatus and methods for occluding hollow body structures, such as blood vessels, and for attaching tissue layers together by providing implantable elements on opposite sides of the structure or tissue layers and drawing the implants together to occlude the body structure and/or bring the tissue layers together. The implants are deliverable in a low profile configuration and self-expand to an enlarged configuration.
Amserl Medical Corporation

Medical-image processing apparatus and medical-image diagnostic apparatus

A medical-image processing apparatus and a medical-image diagnostic apparatus according to an embodiment include an acquisition unit, a generation unit, an identification unit, and a display control unit. The acquisition unit acquires a medical image containing a blood vessel collected by the medical-image diagnostic apparatus.
Toshiba Medical Systems Corporation

Compact low-cost fiberless diffuse speckle contrast flow-oximeter

A low-cost compact fiberless diffuse speckle contrast flowmeter includes a small laser diode and a 2-dimensional imaging device such as a charge coupled device (ccd) or complementary metal oxide semiconductor (cmos) for directly contacting the tissue and measuring a parameter such as blood flow in a deep/thick volume of tissue (up to 10 mm depth). The small laser diode is fixed at a certain distance (0 to 20 mm) from the imaging device and directly contacts the tissue.
University Of Kentucky Research Foundation

Apparatus and estimating blood sugar based on heterogeneous spectrums

An apparatus and a method for determining blood sugar based on heterogeneous spectrums are provided. The blood sugar model generation apparatus includes a data obtainer configured to obtain blood sugar profile data of a user based on a first type spectrum-blood sugar profile relationship model, a second type spectrum measurer configured to measure training second type spectrum data for the skin of the user, and a processor configured to generate an individualized blood sugar model based on the obtained blood sugar profile data and the measured training second type spectrum data..
Korea University Research And Business Foundation

Intrinsic frequency analysis for left ventricle ejection fraction or stroke volume determination

Hardware and software methodology are described for non-invasively monitoring cardiac health. Hemodynamic waveforms variously acquired for a subject are analyzed to calculate or approximate intrinsic frequencies in two domains in two domains across the dicrotic notch.
California Institute Of Technology

Methods and tools for diagnosing insulin resistance and assessing health status using nmr relaxation times for water

The subject invention pertains to a method that involves at least three steps: (1) acquisition of a nmr data set or spin relaxation curve for plasma, serum or whole blood samples, or for tissues monitored from outside the body, (2) analysis of the nmr data or relaxation curve to extract the t2 and/or t1 relaxation times for water (or surrogates thereof), and (3) conversion of the water t2 and/or t1 values (or surrogates thereof) into a measure of someone's health status (referred to as a t2 or t1 health score depending on the value (t1 or t2 or both t1 and t2) associated with the score). The t1 and/or t2 health score utilizes a statistical database derived from previous studies of subjects ranging from normal, healthy individuals to those having varying degrees of hidden or non-hidden metabolic abnormalities, such as inflammation, insulin resistance, lipid abnormalities (dyslipidemia), oxidative stress, brain abnormalities, cognitive impairment or other disorders, and provides a measure of a subject's overall metabolic and brain health status..
University Of North Texas Health Science Center At Fort Worth

Method for evaluating blush in myocardial tissue

Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (roi) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the roi.
Novadaq Technologies Inc.

Tracking cardiac forces and arterial blood pressure using accelerometers

Modular, miniaturized cardiovascular sensors, systems, methods, and wearable devices for the non-obtrusive evaluation, monitoring, and high-fidelity mapping of cardiac mechanical and electromechanical forces and central arterial blood pressure are presented herein. The sensor manufacturing process is also presented.

Pressure sensing guidewire and methods for calculating fractional flow reserve

Medical devices and methods for making and using medical devices are disclosed. An example method may include a method for calculating fractional flow reserve including providing a pressure sensing guidewire, advancing the pressure sensing guidewire through a blood vessel to a first position distal of an intravascular occlusion, determining a distal pressure within the body lumen with the pressure sensing guidewire, proximally shifting the pressure sensing guidewire to a second position proximal of the occlusion, determining a proximal pressure within the body lumen with the pressure sensing guidewire, measuring an aortic pressure, and calculating a pressure drift.
Boston Scientific Scimed, Inc.

Physiological monitoring device, physiological monitoring method and non-transitory computer readable storage medium for implementing the physiological monitoring method

A physiological monitoring device, a physiological monitoring method and a non-transitory computer readable storage medium for implementing the physiological monitoring method are provided. The physiological monitoring device has a blood pressure sensing module, a motion sensing module and a processor.
Htc Corporation

Container for catheter simulator and heart model accommodated in said container

A container 10 for a catheter simulator comprising an accommodating unit 10a for accommodating a liquid, the accommodating unit 10a being defined by side walls 11 to 14 and a bottom face 15. On the side walls, there are formed connection units 11a and 11c capable of retaining any one of the heart models selected from a four-chamber heart model, a coronary artery model, and a tavi model, the heart model being installed in the accommodating unit 10a in a state of having the accommodating unit filled with a liquid; and installation parts 11d, 12a, and 13a for inserting a catheter from the outside of the container into simulated blood vessels of the heart model..
Fuyo Corporation

Medical image processing apparatus and medical image processing method

There is provided a medical image processing apparatus which includes a first extraction unit configured to extract coronary arteries depicted in images of a plurality of time phases relating to the heart, and to extract at least one stenosed part depicted in each coronary artery; a calculation unit configured to calculate a pressure gradient of each of the extracted coronary arteries, based on tissue blood flow volumes of the coronary arteries; a second extraction unit configured to extract an ischemic region depicted in the images; and a specifying unit configured to specify a responsible blood vessel of the ischemic region by referring to a dominance map, in which each of the extracted coronary arteries and a dominance territory are associated, for the extracted ischemic region, and to specify a responsible stenosis, based on the pressure gradient corresponding to a stenosed part in the specified responsible blood vessel.. .
Toshiba Medical Systems Corporation

Binding assay signal analysis

Methods for determining a sample concentration of target entities in a sample, for example, determining a concentration of target antigens or antibodies in a blood sample or other biological sample.. .
Biosurfit, S.a.

Microfluidics based fetal cell detection and isolation for non-invasive prenatal testing

Embodiments disclosed herein provides methods for isolation of fetal cells for non-invasive prenatal diagnosis, comprising: providing a maternal blood sample; applying the maternal blood sample to a filter integrated on a microfluidic device to thereby enrich the nucleated blood cells from the maternal blood sample; labeling the enriched nucleated blood cells, within the microfluidic device, with a fluorescent binding moiety or affinity molecule that specifically binds to a fetal cell-specific antigen or a non-fetal cell-specific antigen; and isolating the fetal cells. Embodiments disclosed herein provide integrated microfluidic devices for non-invasive isolation of fetal cells, comprising: a filter; a binding moiety or affinity molecule that specifically binds to a fetal cell-specific antigen or a non-fetal cell-specific antigen; and a microscopy-visualizable chamber..
Unimed Biotech (shanghai) Co., Ltd.

Mass exchange the use thereof

There is described a method of use of a mass exchanger. In the method the mass exchanger comprises: a first channel for accommodating flow of a liquid to be treated; and a second channel for accommodating flow of a treatment agent, the first and second channels have a permeable membrane provided between them, so as to allow transfer of selected species between the first channel and the second channel.
Haemair Limited

Proton-binding polymers for oral administration

Pharmaceutical compositions for and methods of treating an animal, including a human, and methods of preparing such compositions. The pharmaceutical compositions contain crosslinked amine polymers and may be used, for example, to treat diseases or other metabolic conditions in which removal of protons and/or chloride ions from the gastrointestinal tract would provide physiological benefits such as normalizing serum bicarbonate concentrations and the blood ph in an animal, including a human..
Tricida, Inc.

Device visualization through optical shape sensing of a guidewire

A medical device deployment system includes a main body (101) and a guidewire (103) capable of being passed through the main body and including a lumen. An optical shape sensing (oss) system (104) is configured to pass through the lumen in the guidewire.
Koninklijke Philips N.v.

Transparent pressure dressing enabling hemostasis of blood

A transparent pressure dressing device enables hemostasis of blood in a perforation of a blood vessel. The transparent pressure dressing device includes a rectangular plate shaped artificial hand component and one or more adhesive fins.

Systems and methods of monitoring autoregulation

A system for monitoring autoregulation includes an oxygen saturation sensor configured to obtain an oxygen saturation signal indicative of an oxygen saturation of a patient. The system also includes a controller having a processor configured to receive a blood pressure signal indicative of a blood pressure of the patient and the oxygen saturation signal, determine a change in the oxygen saturation signal and a change in the blood pressure signal over a period of time, and provide an indication that the patient's autoregulation is intact if the oxygen saturation changes by more than an oxygen saturation threshold and if the blood pressure changes by less than a blood pressure threshold during the period of time..
Covidien Lp

Blood typing instructional system

This teaching tool can include: a base having an a base opening, a b base opening, and a rh base opening; a set of antibody assemblies including; a blood cell model having an set of openings for receiving at least one of a set of antigen assemblies wherein when the a antigen head of the blood cell antigen assembly is received into the a assembly, a agglutinate is represented, wherein the b antigen head of the blood cell antigen assembly is received into the b assembly, b agglutinate is represented, and wherein the rh antigen head of the blood cell antigen assembly is received into the rh assembly, rh agglutinate is represented; and, a capillary representation defining a capillary cavity for comparison with a, b, or rh agglutinated representations to determine if the a, b or rh agglutinated can be received in the capillary representation.. .

Systems and methods for automated image classification and segmentation

Optical coherence tomography (oct) may be used to acquire cross-sectional or volumetric images of any specimen, including biological specimens such as the retina. Additional processing of the oct data may be performed to generate images of features of interest.

Image processing apparatus, image processing method, and program therefor

Provided is an image processing apparatus configured to process an image of a fundus of an eye, which is capable of simply and accurately measuring a distribution of cells that form a blood vessel wall of an eye. The image processing apparatus includes: an image acquiring unit configured to acquire an image of an eye; a vessel feature acquiring unit configured to acquire membrane candidate points that form an arbitrary wall of a blood vessel based on the acquired image; and a cell identifying unit configured to identify a cell that forms the wall of the blood vessel based on the membrane candidate points..
Canon Kabushiki Kaisha

Imaging blood cells

This document describes methods, systems and computer program products directed to imaging blood cells. The subject matter described in this document can be embodied in a method of classifying white blood cells (wbcs) in a biological sample on a substrate.
Roche Diagnostics Hematology, Inc.

Use of an anti-alpha-synuclein antibody to diagnose an elevated level of alpha-synuclein in the brain

This disclosure relates to the use of anti-α-synuclein antibody to diagnose an elevated level of α-synuclein in the brain. Specifically, the disclosure relates to the method of assessing the levels of α-synuclein in a blood plasma or csf following administration to the test subject of an anti-α-synuclein antibody or antigen-binding fragment thereof, which can bind α-synuclein with sufficient activity to alter the net efflux of α-synuclein from brain to blood, or from brain to csf..
Biogen International Neuroscience Gmbh

Biomarkers for inflammatory bowel disease

The present invention provides a method of assessing whether an individual is at high risk or low risk of inflammatory bowel disease (ibd) progression by determining the expression level of two or more genes in a whole blood sample. Also provided are methods for treating ibd in an individual who is determined to be at high risk or low risk for ibd progression, and kits for assessing whether an individual is at high risk or low risk for ibd progression.
Cambridge Enterprise Limited

Biomarkers for inflammatory bowel disease

The present invention provides a method of assessing whether an individual is at high risk or low risk of inflammatory bowel disease (ibd) progression by determining the expression level of two or more genes in a whole blood sample. Also provided are methods for treating ibd in an individual who is determined to be at high risk or low risk for ibd progression, and kits for assessing whether an individual is at high risk or low risk for ibd progression.
Cambridge Enterprise Limited

Method of identifying and treating a person having a predisposition to or afflicted with a cardiometabolic disease

The invention relates to method for identifying and selecting a subject with increased risk of developing a cardiometabolic disease and optionally, providing a personalized medicine method, which may involve sequencing at least part of a genome of one or more cells in a blood sample of the subject and identifying from said sequencing one or more mutations in one or more somatic mutations.. .
The Brigham And Women's Hospital, Inc.

Editing profiling of pde8a pre -mrna: use as specific biomarker of adars activities in human tissues to diagnose and to predict and assess therapeutic efficacy and/or efficiency or potential drug side effects

The present invention relates to the use of the editing profile of pde8a pre-mrna as a specific bio marker of adars activities in evolved primate, particularly in human tissues. The present invention also relates to an in vitro method for predicting in human an alteration of the mechanism of the adars catalysed pre-mrna editing of target genes, by analysing the pde8a pre-mrna editing profile in a peripheral tissue sample containing cells expressing said pde8a pre-mrna, such as blood sample.
Alcediag

Compositions and methods to promote erythropoiesis

Described herein are compositions and methods for enhancing erythropoiesis in an individual in need thereof. Specifically agents that decrease the expression of exosc10, such as inhibitory nucleic acid molecules, produce an increase in red blood cell production in the individual..
Wisconsin Alumni Research Foundation

Methods and biomarkers for detection and treatment of langerhans cell histiocytosis

The present invention relates to methods and biomarkers for detection and characterization of langerhans cell histiocytosis in biological samples (e.g., tissue samples, blood samples, plasma samples, cell samples, serum samples). In particular, the present invention provides compositions and methods for diagnosing a patient as having a langerhans cell histiocytosis by identifying mutations in the map2k1 gene or gene products..
The Regents Of The University Of Michigan

Factor viii proteins having ancestral sequences, expression vectors, and uses related thereto

This disclosure relates to recombinant or chimeric fviii proteins, variants, and vectors encoding the proteins containing one or more ancestral mutations. In certain embodiments, one or more protein domains comprise amino acid sequences that are derived from ancestrally reconstructed amino acid sequences.
Georgia Tech Research Corporation

Antagonists of actriib and uses for increasing red blood cell levels

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
Acceleron Pharma Inc.

Column-based device and retrieval of rare cells based on size, and uses thereof

A column-based device and method for retrieving cells of interest were enclosed. The said device comprises a column comprising (i) an inner wall defining an inner chamber with inlet and outlet openings, (ii) a perforated plug disposed adjacent to the outlet opening, (iii) a sleeve insert with a channel and disposed within the chamber and adjacent to the perforated plug, and (iv) a filtering means housed within sleeve insert sandwiched between two sealing means.
Agency For Science, Technology And Research

Devices, systems, and methods for inducing dermal blood vessel leakage

The present disclosure relates generally to devices, systems, and methods for diagnosis and treatment via laser-treated skin and, more particularly, to devices, systems, and methods for inducing leakage or rupture of one or more blood vessels comprising the dermis for various diagnostic and therapeutic applications. Other aspects of the present disclosure can include methods for detecting one or more target analytes in a dermis of a subject, methods for facilitating skin-to-blood delivery of agent in a subject, and methods for collecting a fluid sample from the dermis of a subject..
The General Hospital Corporation Dba Massachusetts General Hospital

Apparatus and methods for optimizing intra-cardiac pressures for improved exercise capacity

Systems and methods are provided for optimizing hemodynamics within a patient's heart, e.g., to improve the patient's exercise capacity. In one embodiment, a system is configured to be implanted in a patient's body to monitor and/or treat the patient that includes at least one sensor configured to provide sensor data that corresponds to a blood pressure within or near the patient's heart; at least one component designed to cause dyssynchrony of the right ventricle, and a controller configured for adjusting the function of the at least one component based at least in part on sensor data from the at least one sensor..
Cardioflow Technologies, Llc

Hyperoxygenation/hyperthermia treatment apparatus

The described invention is a hyperthermia and hyperoxygenation medical apparatus for treating diseases of the blood and purification of stored blood supplies. The invention comprises a hollow chamber through which blood is made to flow.

Coated vaso-occlusive treatment of aneurysms

A method is described herein for the treatment of intracranial aneurysms. The method comprises inserting into an aneurysm an embolism coil coated with a polymeric coating comprising a genipin, such as genipin or a derivative thereof, thereby increasing the stability of clots within the aneurysm.
Carnegie Mellon University

Optimised coding sequence and promoter

An optimized coding sequence of human blood clotting factor eight (viii) and a promoter may be used in vectors, such as raav, for introduction of factor viii, and/or other blood clotting factors and transgenes. Exemplary of these factors and transgenes arc alpha-1-antitrypsin, as well as those involved in the coagulation cascade, hepatocye biology, lysosomal storage, urea cycle disorders, and lipid storage diseases.
St. Jude Children's Research Hospital

Pathogen-inactivated red blood cell compositions

The present invention provides pathogen-inactivated red blood cell compositions.. .
Cerus Corporation

Intraluminal devices configured for directional expansion

Methods and devices useful, for example, in the field of angioplasty and stenting are disclosed. In some embodiments, the methods, devices and kits are configured for directional expansion inside a lumen, for example of a blood vessel obstructed by plaque.

Embolus blood clot filter removal system and method

A blood filter extraction system for extracting a blood filter from within a blood vessel. The system includes an extraction wire, or plurality of such wires, positioned within an elongated tubular member.
C.r. Bard, Inc.

Intravascular devices and delivery systems and uses thereof

In general, the invention features an intravascular device, a delivery system, and methods for filtering or deflecting emboli or other large objects from entering a protected secondary vessel or vessels the intravascular device of the invention may prevent passage of a particle in a blood vessel from passing through a filter supported by a frame, upper and lower stabilizers, and a wire. The wire may be used to stabilize the device upon its deployment and installation within a blood vessel.
Keystone Heart Ltd.

Systems and methods for aspirating from a body lumen

An aspiration device can be used to aspirate an obstruction from a blood vessel. The aspiration device is configured to allow controlled one-handed aspiration yet maintain a syringe plunger feel of vacuum.
Silk Road Medical, Inc.

Implantable damping devices for treating dementia and associated systems and methods of use

Devices, systems, and methods for reducing stress on a blood vessel are disclosed herein. A damping device configured in accordance with embodiments of the present technology can include an anchoring member coupled to a flexible, compliant damping member including a generally tubular sidewall having an outer surface, an inner surface defining a lumen configured to direct blood flow, a first end portion and a second end portion, and a damping region between the first and second end portions.
The Brain Protection Company Pty Ltd

Bio-absorbable wound closure device and method

A wound closure device comprises a first frame and a flexible tubular section connected to the first frame, the first frame implantable through a wound in a patient's skin into a lumen of a blood vessel with a portion of the tubular section extending out through the skin. The tubular section has a first portion and a second portion, a wall of the tubular section defining a coaxial inner bore.
Edwards Lifesciences Corporation

Systems and methods to determine surrogates of blood pressure

Embodiments of the present disclosure relate to systems and methods for determining a subject's blood pressure using one or more implantable medical devices (imds). In an embodiment, a medical system comprises: at least one implantable medical device configured to sense signals associated with heart sounds of a subject and a processing unit communicatively coupled to the at least one implantable medical device.
Cardiac Pacemakers, Inc.

Multi-function capillary tube syringe with retractable needle for arterial blood drawing

Implementations of a capillary tube syringe are provided. In some implementations, a capillary tube syringe comprises an elongated hollow outer tube having a proximal end and a distal end and a needle extending from the first end of the outer tube outside the outer tube and extending inside the outer tube.

Non-invasive blood glucose level measurement method and non-invasive blood glucose level measurement device

The non-invasive blood glucose level measurement device (1) is provided with a pulse waveform measurement unit (2) having fbg sensors (4) for measuring an acceleration pulse wave of a test subject; and a data-processing unit (3) for calculating the blood glucose level of the test subject at the point in time of measurement of the acceleration pulse wave, from waveform information of the measured acceleration pulse wave, on the basis of a predetermined correlation. The correlation is a calibration curve constructed by carrying out a pls regression analysis, using the blood glucose level measured by a non-invasive blood glucose method as the objective variable, and a simultaneously-measured acceleration pulse wave as the explanatory variable.
Shinshu University

Blood vessel extraction in two-dimensional thermography

What is disclosed is a system and method for isolating blood vessels in a thermographic image of a patient's breast or any other muscular region of the body. A thermographic image of a patient is received.
Niramai Health Analytix Pvt. Ltd.

Methods and systems for predicting bleeding risk and dose of plasminogen activator

The present disclosure provides a method and system for estimating the clinical responsiveness of a patient to a dose of a plasminogen activating agent to treat a thrombosis, comprising determining a concentration of α2-antiplasmin in a blood sample of the patient, determining a concentration of activated fibrinolysis inhibitor (“tafi”) in the blood sample, determining a concentration of plasminogen activator inhibitor 1 (“pai-1”) in the blood sample, computing a clot lysis time (“clt”) based on the concentrations of a2-antiplasmin, tafi and pai-1 using the equation clt=−2,813.6+31.1*a2-antiplasmin (percent activity)+31.1*tafi (percent activity)+1.49 pai-1 (ug/l), and determining that the patient is at increased risk of hemorrhage when the computed clt is less than a first predetermined cutoff time.. .
Indiana University Research And Technology Corporation

Nucleated red blood cell warning , and flow cytometer using the same

Disclosed are nucleated red blood cell warning devices and methods, and flow cytometers using the same. The devices, methods and flow cytometers can warn whether nucleated red blood cells exist in a blood sample.
Shenzhen Mindray Bio-medical Electronics., Ltd.

Method and material for separating leukocytes or mononuclear cells

An object of the present invention is to provide a separation system and a separation material for efficiently separating white blood cells or mononuclear cells from a biological fluid containing blood cell components. White blood cells or mononuclear cells can be efficiently separated by contacting a biological fluid containing blood cell components with a separation material having an average fiber diameter of at least 2.0 μm but not more than 6.0 μm and an air permeability coefficient m of at least 6.2 but not more than 35 to capture white blood cells on the separation material, and recovering the captured white blood cells or mononuclear cells using a detachment solution..
Kaneka Corporation

Hypothermic 3d bioprinting of living tissues supported by perfusable vasculature

The present disclosure provides compositions and methods for producing hydrogel matrix constructs. Methods of using hydrogel matrix constructs for tissue repair and regeneration and for the oxygenation of red blood cells are also disclosed..
William Marsh Rice University

Antibody substituting for function of blood coagulation factor viii

The present inventors produced a variety of bispecific antibodies that specifically bind to both f. Ix/f.
Chugai Seiyaku Kabushiki Kaisha

Needle and manufacturing method thereof

The present invention suppresses the formation of a pocket in a wall of a puncture route when a dull needle is moved forward along the puncture route. In order to achieve such aim, the invention provides a needle to be inserted into a puncture route extending from skin to a blood vessel under the skin to puncture the blood vessel, wherein: the needle is formed in a tubular shape and has an inclined end face at a tip of the needle, the inclined end face being inclined relative to an axis of the needle, a tip end of the inclined end face defining an unsharp edge; the needle has a flexibility of needle elastic modulus ne=1-900 nmm as defined by an equation to be set forth below; a material of the needle is a resin; and the needle is manufactured by injection molding using a ring-shaped gate..
Togo Medikit Co., Ltd.

Puncture assistance system

A puncture assistance system provides information on a collapse state of a blood vessel to be punctured, caused by pressing action of an ultrasonic probe, when ultrasonic images of the blood vessel are acquired. A puncture assistance system 10 includes: vascular diameter detecting means 18 for detecting a vascular diameter during acquisition of the ultrasonic images from an ultrasonic diagnostic device 11; puncture assistance information generating means 12 for generating puncture assistance information for determination of whether or not puncture is allowed to be performed based on a collapse state of a blood vessel b caused by pressing action of an ultrasonic probe 15 against skin s by comparing a current vascular diameter detected by the vascular diameter detecting means 18 with a standard vascular diameter stored in advance; and a monitor 19 that presents the puncture assistance information..
Kyushu University, National University Corporation

Methods and systems for extracting blood vessel

A method for extracting a blood vessel may include acquiring an image relating to a blood vessel, the image including multiple slices; determining a region of interest in the image; establishing a blood vessel model; and extracting the blood vessel from the region of interest based on the blood vessel model.. .
Shanghai United Imaging Healthcare Co., Ltd.

Bio-adaptable implantable sensor apparatus and methods

Biocompatible implantable sensor apparatus and methods of implantation and use. In one embodiment, the sensor apparatus is an oxygen-based glucose sensor having biocompatibility features that mitigate the host tissue response.
Glysens Incorporated

Blood pressure monitor

Technologies are generally described for systems, devices and methods relating to blood pressure monitors. Blood pressure monitors may include a processor and a structure effective to be in communication with the processor.
Empire Technology Development Llc

Assessing cardiovascular function using an optical sensor

This document describes assessing cardiovascular function using an optical sensor, such as through sensing relevant hemodynamics understood by pulse transit times, blood pressures, pulse-wave velocities, and, in more breadth, ballistocardiograms and pressure-volume loops. The techniques disclosed in this document use various optical sensors to sense hemodynamics, such as skin color and skin and other organ displacement.
Google Inc.

Assessing cardiovascular function using an optical sensor

This document describes assessing cardiovascular function using an optical sensor, such as through sensing relevant hemodynamics understood by pulse transit times, blood pressures, pulse-wave velocities, and, in more breadth, ballistocardiograms and pressure-volume loops. The techniques disclosed in this document use various optical sensors to sense hemodynamics, such as skin color and skin and other organ displacement.
Google Inc.

Image processing apparatus, image processing method, and program therefor

Provided is an image processing apparatus configured to process an image of a fundus of an eye to accurately measure thicknesses of membranes that form a blood vessel wall of an eye. The image processing apparatus includes: an image acquiring unit configured to acquire an image of an eye; a vessel feature acquiring unit configured to acquire membrane candidate points that form an arbitrary wall of a blood vessel based on the acquired image; a cell identifying unit configured to identify a cell that forms the wall of the blood vessel based on the membrane candidate points; and a measuring position acquiring unit configured to identify a measuring position regarding the wall of the blood vessel based on a position of the identified cell..
Canon Kabushiki Kaisha

System and authenticating a mobile transaction by verifying the presence of a real person

A system and method for verifying the presence of a live, real individual when performing a mobile payment transaction in a more convenient and accurate manner. The system includes a mobile computing device, the mobile computing device comprises at least one light source configured to emit light through a body part of a user of the mobile computing device; at least one light sensor configured to measure reflected light from the at least one light source reflected off of blood vessels within the user; and a camera configured to capture at least one image or vide of the user to obtain a measurement indicative of changes in blood volume based on the measured reflected light and at least one image or video of a payment instrument of the user..

Reconstitution solution for spray-dried plasma

The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying.
The Government Of The United States

Blood analysis systems and methods

blood typing systems and methods are provided. In one embodiment, the method may be achieved by applying a sample to a surface of a substrate having one or more binding agents immobilized thereon, wherein the one or more binding agents are capable of binding to one or more substances in the sample; substantially removing unbound material from at least a portion of the substrate having immobilized binding agent; and detecting substances bound to the one or more binding agents immobilized on the substrate; wherein the applying the sample to the surface of the substrate step is concurrent with the removing unbound material from at least a portion of the substrate step.
Bio-rad Innovations

Immunochromatographic test strip for detecting object in red blood cell-containing sample and immunochromatography using the test strip

A problem of the present invention is to provide an immunochromatographic test strip avoiding agglutination of colloidal gold while red blood cells in whole blood are agglutinated and then separated and removed in the case of using polybrene as a hemagglutinating agent and the colloidal gold conjugates as a detection reagent, and to provide immunochromatography using the test strip. To solve the problem, the present inventors reviewed the composition of the existing reagent itself from a completely different viewpoint rather than the selection of type or amount of polyanions, and as a result of extensive study on each element, the inventors surprisingly found that agglutination of colloidal gold may be suppressed by using a particular additive without neutralization by polyanions..
Sekisui Medical Co., Ltd.

Devices and methods for detection and quantification of immunological proteins, pathogenic and microbial agents and cells

The present invention provides a method and microfluidic immunoassay pscreen™ device for detecting and quantifying the concentration of an analyte in a liquid sample by using antigen-specific antibody-coated magnetic-responsive micro-beads. The methods and devices of the present invention have broad applications for point-of-care diagnostics by allowing quantification of a large variety of analytes, such as proteins, protein fragments, antigens, antibodies, antibody fragments, peptides, rna, rna fragments, functionalized magnetic micro-beads specific to cd4+, cd8+ cells, malaria-infected red blood cells, cancer cells, cancer biomarkers such as prostate specific antigen and other cancer biomarkers, viruses, bacteria, and other pathogenic agents, with the sensitivity, specificity and accuracy of bench-top laboratory-based assays..
Carnegie Mellon University

Method and system for counting white blood cells electrically

A system and method for quantifying white blood cells in a blood sample is described. The system includes a sample medium for depositing the same blood.
United Arab Emirates University

Method and device for determining the coagulation time of a blood sample, and reaction vessel

This determination method comprises the steps consisting of providing a reaction vessel (2) containing a blood sample (33) and a ferromagnetic ball (11) placed on a raceway (9) provided in the bottom of the reaction vessel (2), subjecting the ball (11) to a magnetic field so as to move the ball along the raceway (9) in an oscillatory motion, exposing the blood sample to an incident light beam (36), detecting a light beam (38) transmitted through the reaction vessel (2) and coming from the incident light beam (36) in such a way as to provide a measurement signal, carrying out a first processing of the measurement signal in such a way as to provide a first signal representative of the variation of at least one physical quantity representative of the movement of the ball (11), carrying out a second processing of the measurement signal in such a way as to provide a second signal representative of the variation of at least one optical property of the blood sample, determining a first value of the coagulation time of the blood sample from the first signal, and determining a second value of the coagulation time of the blood sample from the second signal.. .
Diagnostica Stago

Dissolved-oxygen sensor utilizing ionic oxygen motion

An apparatus includes an oxide layer having ion transport channels that facilitate the migration of oxygen ions from a first side to a second side of the layer. Specifically, molecular oxygen is decomposed into oxygen ions at the first side, and oxygen ions recombine into molecular oxygen at the second side.
International Business Machines Corporation

Hematology systems and methods

Aspects and embodiments of the instant disclosure provide a particle and/or intracellular organelle alignment agent for a particle analyzer used to analyze particles contained in a sample. An exemplary particle and/or intracellular organelle alignment agent includes an aqueous solution, a viscosity modifier, and/or a buffer.
Iris International, Inc.

Methods and kits for detecting cell-free pathogen-specific nucleic acids

The present invention relates to a method for detecting a target nucleic acid derived from a pathogen in a subject. The method comprises (a) amplifying the nucleic acid sequence of the target nucleic acid, which is obtained from a cell-free fraction of a blood sample from the subject, to produce a double stranded dna is produced, and (b) detecting the double stranded dna.
Occam Biolabs, Inc.

Embolization microcatheter

Microcatheter for delivering a substance (e.g., infusion agent including embolization material and/or contrast enhancing material) in a small blood vessel towards a target bodily part. Includes a single lumen surrounded by tubular wall having outer diameter and opened at both ends; tubular wall proximal portion is connectable to a pressure source and reservoir containing infusion agent, and tubular wall distal portion ends with a tip; the tubular wall distal portion includes an infusion agent flow disruption section configured to disrupt passage therethrough of incoming retrograded flow of infusion agent, during continuous delivery of infusion suspension from the reservoir to the tip.
Accurate Medical Therapeutics Ltd.

Endoluminal delivery of anesthesia

Described herein are methods and devices for selectively applying fluids (particularly anesthetics) to a target tissue from within a blood vessel while minimizing the amount of fluid applied to non-target tissue. The injection catheters described herein may include an elongate body, a directional injector, and one or more holdfasts for securing the catheter before extending the injector.
Silk Road Medical, Inc.

Closed-loop control of insulin infusion

Disclosed herein are devices, methods and systems for monitoring and detection of adverse events in a subject. In an embodiment, an insulin delivery device includes an insulin injection device in communication with a controller for controlling the insulin injection device.
Medicus Engineering Aps

Blood isolation and extraction thereof

A blood isolation and extraction method includes: providing a predetermined amount of blood; utilizing a platelet filter unit to filter the predetermined amount of blood to generate a filtered blood; utilizing a plasma separation unit to divide the filtered blood into a plasma layer and a blood cell layer for separating blood cells from blood plasma; and extracting the blood plasma from the plasma layer and the blood cells from the blood cell layer. In another embodiment, the blood isolation and extraction method further includes: providing a platelet-washing unit to wash the platelet filter unit with a solution to produce a platelet solution; and mixing the platelet solution with the blood plasma to produce a platelet and plasma mixed solution..
Neoasia Limited

Luminal vessel coating for arteriovenous fistula

This disclosure provides a method for improving maturation of an arteriovenous fistula (avf) in a patient in need of hemodialysis, which method entails applying a solution to the internal wall of a lumen of an avf; and restoring or initiating blood flow in the avf, wherein the solution comprises an effective amount of a synthetic proteoglycan comprises a glycan having from about 1 to about 80 collagen-binding peptide(s) bonded to the glycan. Also provided are methods for preparing a vascular graft for a bypass surgery, comprising contacting the internal wall of a section of a blood vessel with a solution comprising an effective amount of the synthetic proteoglycan..
Symic Ip, Llc

Tissue transplantation involving, and tissues modified by decellularization and recellularization of donor tissues for minimized or obviated rejection reactions

The method of tissue transplantation involving recellularizing of a donor organ with the utilization of the recipient's cytokines collected from the recipient's blood plasma at less than systemic pressure, and at the temperature greater than freezing and less than normal systemic temperature of the recipient's blood. Specifically, a method of harvesting a platelet-derived growth factors from platelet rich plasma (prp), the growth factors having increased weight..

Canine microbe preparations for increasing oxytocin

The inventions disclosed herein relate to the findings that l. Reuteri bacteria isolated from dog saliva is capable of modulating a subject's body weight.

Use of ellagic acid dihydrate in pharmaceutical formulations to regulate blood glucose levels

The present invention relates generally to pharmaceutical compositions and methods of use that include an ellagic acid dihydrate compound that assists in increasing glucose uptake.. .
Halo Life Science, Llc

Use of nanoparticles coated with red blood cell membranes to enable blood transfusion

The present invention relates to methods, combinations and pharmaceutical compositions for supplying a blood source from a donor source with a mis-matched blood type, or potentially a mis-matched blood type, to a recipient, using, inter alia, an effective amount of a nanoparticle comprising a) an inner core comprising a non-cellular material, and b) an outer surface comprising a cellular membrane derived from a red blood cell, the cellular membrane of the nanoparticle comprising a blood type antigen that exists on the red blood cell from the donor source, but is missing or potentially missing on red blood cells of the recipient.. .
Cellics Therapeutics, Inc.

Stent and kit of stents for adjustable interventional reduction of blood flow

A kit of stents and an adjustable multi-lumen stent for adjustable interventional reduction of blood flow in a blood vessel. The kit includes: a first reduction stent having in an expanded conformation at least one widened section and a narrowed section, the narrowed section defining a central lumen providing reduced fluid communication between an upstream end and a downstream end of the first reduction stent; at least one expandable dilatation stent having a tubular form insertable into and expandable in the central lumen of the first reduction stent to define an enlarged central lumen; at least one second reduction stent having a narrowed tubular section insertable into the central lumen of the first reduction stent or the central lumen of the dilatation stent to define an reduced central lumen, and having an anchoring element at its upstream end..
Intellistent Ag

Articles and methods for sample preparation

Articles and methods for preparing a surface for obtaining a patient sample, such as blood, are generally provided. In some embodiments, the methods involve wiping a surface of skin of a patient in preparation for obtaining a sample (e.g., a blood sample) from the patient.
Opko Diagnostics, Llc

Device for restricting blood flow to aneurysms

There is provided herein a non-occlusive blood restricting device for treating a vascular malformation, the blood restricting device consisting of a wire comprising a first section configured to be coiled into a first coil when deployed within the vascular malformation; wherein the first coil comprises a spiral or sequence of loops, the spiral or sequence of loops having a gradually decreasing diameter; and wherein the first coil is configured to line a neck and/or a wall of the vascular malformation so as to at least partially cover an orifice thereof, and a second section configured to be deployed within a blood vessel, adjacent the vascular malformation; wherein the second section is configured to form a second coil, circumferentially lining a wall of the blood vessel.. .
Endostream Medical Ltd.

Dynamic calibration of a blood pressure measurement device

Various embodiments enable calibrating a non-invasive blood pressure measurement device by determining multiple parameters defining a stress-strain relationship of an artery of a patient. The device may obtain output signals from a blood pressure sensor at two or more measurement elevations.
Qualcomm Incorporated

Tonometry based blood pressure measurements using a two-dimensional force sensor array

Representative methods, apparatus and systems are disclosed for blood pressure and other vital sign monitoring using arterial applanation tonometry, including ambulatory blood pressure and other vital sign monitoring. A representative system comprises a wearable apparatus.
Northwestern University

Assessing endothelial function and providing calibrated ufmd data using a blood pressure cuff

Methods and apparatus are provided for assessing endothelial function in a mammal. In certain embodiments the methods involve using a cuff to apply pressure to an artery in a subject to determine a plurality of baseline values for a parameter related to endothelial function as a function of applied pressure (pm); b) applying a stimulus to the subject; and applying external pressure pm to the artery to determine a plurality of stimulus-effected values for the parameter related to endothelial function as a function of applied pressure (pm); where the baseline values are determined from measurements made when said mammal is not substantially effected by said stimulus and differences in said baseline values and said stimulus-effected values provide a measure of endothelial function in said mammal..
The Regents Of The University Of California

Reconstitution solution for spray-dried plasma

The present invention relates to a reconstitution solution for spray dried plasma having a non-anticoagulant compound that does not bind calcium. When the reconstitution solution of the present invention is mixed with spray dry plasma, the reconstituted plasma mediates platelet adhesion and aggregation about the same as or greater than the starting plasma prior to spray drying.
Velico Medical, Inc.

Biomarker for diagnosing vascular diseases and the uses thereof

Provided are a composition for diagnosing vascular disease including an agent measuring a level of interleukin 12 receptor β2 protein in the blood, and a kit for diagnosing vascular disease including the same. Further, provided is a method for diagnosing vascular disease, the method including the step of measuring a level of interleukin 12 receptor β2 protein in a blood sample separated from an individual suspected of having vascular disease.
Wonmedical Corp.

Substituted bridged urea analogs as sirtuin modulators

The present invention relates to novel substituted bridged urea analog compounds of formula (i) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as sirtuin modulators useful for increasing lifespan of a cell, and in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.. .
Glaxosmithkline Intellectual Property (no.2) Limited

Apparatus for manufacturing thin-walled bodies of revolution

The technical solution relates to the field of processing polymers and can be used in various branches of the national economy for manufacturing hollow articles of the bodies-of-revolution type (tubes), and in particular for manufacturing semifinished biodegradable polymeric stents which are usable in medicine for replacing hollow organs, for example blood vessels. The apparatus for manufacturing thin-walled bodies of revolution comprises a heatable expander which is mounted rotatably about a longitudinal axis, and a feeder for supplying mouldable material, said feeder being mounted above the expander so as to be movable therealong, wherein the lower part of the feeder is heatable, the expander is hollow with a reflective internal surface, and the heater of the expander is in the form of a laser, the radiation of which is transported into the expander.
Limited Liability Company "biosten" (biosten Llc.)

Lysine delivery systems for blood coagulation

A blood coagulating device can include an absorbent body; and a hemostatic lysine composition associated with the body. The body can have a cylindrical or conical member having a first end having the hemostatic composition, the first end being configured for insertion into a nasal passageway.
Park City Bio, Llc

Interventional catheter system and methods

An interventional catheter is adapted for treating a blood vessel. In an embodiment, the catheter includes an elongate shaft sized for insertion in a blood vessel and a stent positioned on a distal region of the elongate shaft.
Silk Road Medical, Inc.

Intravenous catheter insertion and blood sample devices and use

A catheter insertion device includes a housing, a needle, a catheter, and a guide wire. The needle has a proximal end positioned in the housing and a distal end extending beyond a distal end of the housing.
Vascular Pathways, Inc.

Coating of a vascular endoprosthesis

The invention concerns a method for coating a vascular endoprosthesis, wherein the vascular endoprosthesis is at least partially wetted with a first solution of an active ingredient and the areas of the vascular endoprosthesis at least partially wetted with the first solution of the active ingredient are at least partially wetted with a liquid containing water and/or at least an alcohol. The additional wetting with a liquid containing water/alcohol imparts a different consistency to the active ingredient layer, specifically making it is less transparent and lacquer-like and more chalklike and opaque.
Aachen Scientific International Pte. Ltd.

Coated endovascular prostheses for aneurism treatment

The present technology relates generally to endovascular prostheses. More particularly, the disclosure relates to endovascular prostheses having an outer surface of a graft material thereof associated with a hydrogel composition, which may swell upon implantation within a blood vessel, thereby mediating various complications associated with endovascular procedures.
Medtronic Vascular, Inc.

Biocompatible implants comprising engineered endothelial cells

The present invention involves implants suitable for surgical implantation into subjects. In some embodiments the implants comprise a biocompatible scaffold material and blood vessels containing engineered endothelial cells—such as e4orf1+ engineered endothelial cells or engineered endothelial cells that express certain marker molecules.
Angiocrine Bioscience, Inc.

Methods and compositions for promoting glucose homeostasis

A method of reducing blood glucose in a subject has been developed. In preferred embodiments, the method involves administering to the subject a specific activator of endogenous mitogen-activated protein kinase kinase 6 (mkk3), mitogen-activated protein kinase kinase 6 (mkk4), mitogen-activated protein kinase kinase 6 (mkk6), p38 mitogen-activated protein kinase (p38mapk), mitogen-activated kinase-activated protein kinase 2 (mk2), or a combination thereof, in an effective amount to reduce blood glucose in a subject.
The Children's Medical Center Corporation

Blood pressure lowering composition containing as active ingredient exopolysaccharide produced by means of ceriporia lacerata

The present invention relates to a blood pressure lowering composition which contains as an active ingredient exopolysaccharide produced by means of ceriporia lacerata, a ceriporia lacerata mycelium culture medium comprising same, or dry powder or an extract of same. The composition can be used as an antihypertensive for preventing or treating hypertension or cerebral apoplexy or as a functional health food having antihypertensive effect..
Fugenbiopharma Co., Ltd.

Transluminal delivery of viruses for treatment of diseased tissue

Methods are provided for treatment of cancer in a subject's body by intraluminal delivery of oncolytic viruses through a balloon catheter or alternative mechanism inserted in a blood vessel or duct leading to a target site of the cancer tissue, or for somatic cell gene therapy of single defective gene-caused other diseases or disorders by similar intraluminal delivery of non-oncolytic viruses to a target site of affected tissue and cells of the disease or disorder, wherein during delivery of the oncolytic or non-oncolytic virus, the designated vessel or duct is selectively occluded at both ends of the target site by two spaced-apart inflated balloons of the catheter to block perfusion therethrough and allow control of the volume of virus delivered to the target site so as to increase concentration and pressure of the virus thereat sufficient to enable viral penetration of an endothelial barrier of the vessel or duct without compromise thereof and into diseased cells in the vicinity of the target site toward achieving a desired therapy.. .
Scicotec Gmbh

Non-anticoagulant sulfated or sulfonated polysaccharides

The present invention provides non-anticoagulant sulfated or sulfonated polysaccharides (nasps), which accelerate the blood clotting process. Also provided are pharmaceutical formulations comprising a nasp of the invention in conjunction with a pharmaceutically acceptable excipient and, in various embodiments, these formulations are unit dosage formulations.
Baxalta Gmbh

Methods and drug therapies for patency of occluded blood vessels following angioplasty

The present disclosure relates to a method of maintaining luminal patency of a blood vessel following vessel injury, the method including administering a composition comprising at least one lysyl oxidase inhibitor and d-penicillamine to a subject in need thereof compositions to support the methods are also provided.. .
Nephrogenesis, Llc

Modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto

The present invention relates to amide derivatives of formula (xiiia) and pharmaceutical compositions thereof that modulate the activity of the pgi2 receptor. Compounds of the present invention and pharmaceutical compositions thereof are directed to methods useful in the treatment of: pulmonary arterial hypertension (pah); idiopathic pah; familial pah; pah associated with a collagen vascular disease, a congenital heart disease, portal hypertension, hiv infection, ingestion of a drug or toxin, hereditary hemorrhagic telangiectasia, splenectomy, pulmonary veno-occlusive disease (pvod) or pulmonary capillary hemangiomatosis (pch); pah with significant venous or capillary involvement; platelet aggregation; coronary artery disease; myocardial infarction; transient ischemic attack, angina; stroke; ischemia-reperfusion injury; restenosis; atrial fibrillation; blood clot formation in an angioplasty or coronary bypass surgery individual or in an individual suffering from atrial fibrillation; atherosclerosis; atherothrombosis; asthma or a symptom thereof; a diabetic-related disorder such as diabetic peripheral neuropathy, diabetic nephropathy or diabetic retinopathy; glaucoma or other disease of the eye with abnormal intraocular pressure; hypertension; inflammation; psoriasis; psoriatic arthritis; rheumatoid arthritis; crohn's disease; transplant rejection; multiple sclerosis; systemic lupus erythematosus (sle); ulcerative colitis; ischemia-reperfusion injury; restenosis; atherosclerosis; acne; type 1 diabetes; type 2 diabetes; sepsis; and chronic obstructive pulmonary disorder (copd)..
Arena Pharmaceuticals, Inc.

Post-surgical obstruction treatment recovery and rehabilitation therapy

Medical pressure therapy can be used on a patient having undergone treatment to reopen an arterial obstruction, such as a stenosis or occlusion. The medical pressure therapy can establish and maintain persistently good distal runoff.
Otivio As

Intravascular implants and methods of using the same

An intravascular implant and methods of using the implant within the vasculature of the body, for example near a vascular aneurysm, are disclosed. A method of treating an aneurysm includes positioning a vascular graft comprising a tubular channel having a first end and a second end in a blood vessel, securing the vascular graft in place with an expandable anchoring member, and filling a seal cuff on the vascular graft, wherein the seal cuff extends radially outward beyond an exterior surface of the vascular graft, wherein the seal cuff comprises a first seal portion and a second seal portion and wherein the first seal portion is separated from the second seal portion by a first gap and a second gap along a circumference of the seal cuff..

Embolic protection device

An embolic protection device for use in a patient's blood vessel, such as the aorta, has an approximately cylindrical outer structure made of a filter mesh material and an approximately conical inner structure also made of a filter mesh material. On the downstream end of the embolic protection device, the wider end of the conical inner structure is joined to the cylindrical outer structure.
Emboline, Inc.

Filter delivery system

A filter delivery device for implanting a vessel filter within a blood vessel of a patient's body. The filter delivery device includes a mechanism for preventing hooks and/or legs on a vessel filter from entangling with each other while the vessel filter is loaded within the delivery device.
C.r. Bard, Inc.

Noninvasive protection from emboli

A system for diverting emboli within a patient can include a device that detects a presence of emboli in a first blood vessel of a patient. A compression member can be aligned, with a second blood vessel of the patient when a collar supporting the compression member is positioned at, least partially around a portion of the patient.
Zhadkevich Medical, Inc.

Microbubble signal based temporal-bone thickness compensation for sonothrombolysis

An ultrasonic intracranial sonothrombolysis pressure amplitude is pre-quantified by using an ultrasound-scanner control unit (110) having an increasing and/or decreasing mode and designed for: with respect to a current mode, interrogating a blockage site iteratively so as to progressively and respectively increase or decrease a pressure amplitude of ultrasound being emitted to the site at which bubbles (144) for oscillating that is caused by the emitted ultrasound are present; iteration to iteration, deriving, from echoes of the emitted ultrasound, a magnitude of an energy of a signal; and automatically identifying, for the quantifying, an iteration that, in comparison with a just-previous iteration, fails to increase the magnitude. The interrogating may span a region that contains or goes through: the obstruction; another part of the blood vessel; and bubble circulation within a neighboring vessel and a neighboring capillary (136).
Koninklijke Philips N.v.

Personal health data collection

The present application provides a personal hand-held monitor for the measurement of a subject's blood pressure and, optionally, one or more other vital signs, comprising a housing located on a personal hand-held computing device or a hand-held component of a computing system; a blood flow occlusion means located in the housing; a pressure sensor adapted to provide an electrical signal indicative of the pressure applied; a means for detecting the flow of blood in the body part of the subject when pressure is applied; and means for receiving electrical signals from the pressure sensor and the blood flow detecting means and for transmitting electrical signals indicative of the pressure and blood flow to the processor of the personal hand-held computing device or the computing system, wherein the processor of the personal hand-held computing device or computing system provide at least a measurement of the blood pressure of a subject. The processor is further adapted to carry out a process to measure a diastolic blood pressure value and a systolic blood pressure value..
Leman Micro Devices Sa

Method and system for estimation of stress of a person using photoplethysmography

A system and method for determining a stress level of a person is provided. The system creates a numerical solution to mathematical model of a blood pressure (bp) regulation, lumped mathematical model of a radial artery and partial differential equation (pde) model of the radial artery.
Tata Consultancy Services Limited

Method, apparatus and computer program for determining a blood pressure value

Method for determining a blood pressure value including the steps of: providing a pulsatility signal, determining a time-related feature and a normalized amplitude-related feature on the basis of the pulsatility signal; and calculating a blood pressure value on the basis of a blood pressure function depending on the time-related feature, the normalized amplitude-related feature and function parameters.. .
Csem Centre Suisse D'electronique Et De Microtechnique Sa - Recherche Et Développement

Diastolic blood pressure measurement calibration

Various embodiments include methods and devices for measuring blood pressure. Various embodiments may include receiving, from one or more arterial measurement sensors, a pulse waveform representing arterial pressure as a function of time for each pulse of a series of blood pressure pulses.
Qualcomm Incorporated

Implantable vital sign sensor

An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end..
Thomas Jefferson University

Blood-flow analysis device for blood-flow simulation, method therefor, and computer software program

The present method is a method for executing a computational fluid analysis on a blood flow at a blood vessel region to be analyzed, and displaying the analysis results, comprising the steps of: obtaining, by a computer, a vascular diameter (d) of an inlet and/or outlet of a blood vessel region to be analyzed from medical images which include said blood vessel region; obtaining, by the computer, an estimated flow rate (q) at the inlet and/or outlet based on the vascular diameter (d); and applying, by the computer, the estimated flow rate (q) to a blood flow characteristics pattern of said blood vessel region and outputting blood flow characteristics at the inlet and/or outlet of the analysis object site.. .
Ebm Corporation

Systems and methods for blood pressure measurement

A method of determining a blood pressure of a patient includes determining a plurality of pressure pulses, wherein each pressure pulse of the plurality of pressure pulses comprises a profile having a maximum profile height. The method also includes determining a pulse score associated with the plurality of pressure pulses, wherein the pulse score is determined based on the profiles of the pressure pulses and the maximum profile heights.
Welch Allyn, Inc.

Systems, devices, and methods for measuring blood pressure of a user

The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes.
Apple Inc.

Vascular pattern detection systems

In the examples provided herein, a vascular pattern recognition system integrated onto a portable card includes a vascular pattern detection system to obtain image data of blood vessels of a finger to be swiped across a detection area on the portable card, wherein the vascular pattern detection system includes a near infrared light source and an image sensor array. The vascular pattern recognition system also includes an image processor to process the image data to generate a scanned vascular pattern and compare the scanned vascular pattern to a pre-stored pattern stored on the portable card to authenticate the image data, and a security processor to generate a transaction code to authorize a transaction upon authentication of the image data..
Hewlett Packard Enterprise Development Lp

Morphological cell parameter-based red blood cell test method and digital holographic microscope used therein

The morphological cell parameter-based erythrocyte test method performs modeling of a 3d image for an erythrocyte to be tested and measures morphological parameters of the erythrocyte based on the 3d image. Therefore, time and effort consumed in measurement may be reduced, and accuracy of the measurement is excellent..

Method of measuring red blood cell membrane fluctuations based on dynamic cell parameters and digital holographic microscope used therefor

Disclosed is a method of measuring red blood cell membrane fluctuations based on dynamic cell parameters using a digital holographic microscope; the method including a step of modeling the three-dimensional images of red blood cells to be measured, and a step of measuring red blood cell membrane fluctuations based on the three-dimensional images. According to this method, since the three-dimensional images of red blood cells to be measured are modeled and red blood cell membrane fluctuations are measured based on the three-dimensional images, red blood cell membrane fluctuations can be measured more easily..
Industry-academic Cooperation Foundation, Chosun U Niversity

Factor v/va-targeting aptamer compositons and methods of using the same

Provided herein are factor v/factor va-targeting aptamer compositions and antidote compositions targeting such aptamer compositions. Methods for preventing blood clots using such compositions are also provided..
Duke University

Modulation of sh2b3 to improve red blood cell production from stem cells and/or progenitor cells

Disclosed herein are methods for producing red blood cells (rbcs) from a population of stem cells and/or progenitor cells. In at least one of the stem cells or progenitor cells, sh2b3 protein activity is decreased, sh2b3 mrna level is decreased, and/or sh2b3 protein level is decreased.
Children's Medical Center Corporation

Methods of using fibroblast growth factor (fgf) 1 with mutation in the heparin binding domain and methods to reduce blood glucose

The present disclosure provides fgf1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an n-terminal deletion, point mutation(s), or combinations thereof.
Salk Institute For Biological Studies

Fibroblast growth factor (fgf) 1 with mutation in the heparin binding domain and methods of use to reduce blood glucose

The present disclosure provides fgf1 mutant proteins having one or more mutations in the heparin binding domain. Such mutants may also have an n-terminal deletion, point mutation(s), or combinations thereof.
The Florida State University Research Foundation, Incorporated

Substituted bridged urea analogs as sirtuin modulators

The present invention relates to novel substituted bridged urea analog compounds of formula (i) or pharmaceutically acceptable salts thereof, corresponding pharmaceutical compositions, processes for making and use of such compounds, alone or in combination with other therapeutic agents, as sirtuin modulators useful for increasing lifespan of a cell, and for use in treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.. .
Glaxosmithkline Intellectual Property (no.2) Limited

Substituted bridged urea analogs as sirtuin modulators

The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
Glaxosmithkline Llc

Drainage devices and methods for use

Devices and methods for draining excess lymph fluid are disclosed. The device can be fixed to the blood vessel adjacent to the thoracic duct.
The Board Of Trustees Of The Leland Stanford Junior University

Systems and methods for therapeutic platelet depletion

Systems and methods are provided for depleting platelets from blood. The system includes a multi-stage blood separation chamber in which blood is separated into red blood cells and platelet-rich plasma.
Fenwal, Inc.

Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator

The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose, improving insulin sensitivity, enhancing phosphorylation of glucose, and improving the therapeutic effectiveness of metformin.
Vtv Therapeutics Llc

Systems and methods for treating a carotid artery

Systems and methods are adapted for treating the carotid artery. The systems include interventional catheters and blood vessel access devices that are adapted for transcervical insertion into the carotid artery.
Silk Road Medical, Inc.

Gauze pad holder for post-surgical intraoral use

A holder for safely securing a gauze pad for use in a post-surgical area in the intraoral cavity of a patient in order to allow a blood clot to form in safe, hygienic and sanitary conditions. The holder provides a holding cavity wherein the gauze pad is secured and held.

Catheter apparatuses for modulation of nerves in communication with the pulmonary system and associated systems and methods

Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft.
Medtronic Ardian Luxembourg

Ultrasound catheter for disrupting blood vessel obstructions

An ultrasonic catheter includes a body and an ultrasound transmission member disposed in the body. A head is coupled to the ultrasound transmission member, wherein a gap separates the head from a body distal end.
Flowcardia, Inc.

Intranasal occlusion device and methods of using the same

An intranasal occlusion device having an inflatable balloon within a sponge that is used to prevent drainage of fluid, such as blood and other fluids into the airway during sinus and nasal minor procedures or surgeries, and methods of using the device to occlude an intranasal cavity of a patient. The device provides for suction to remove the fluid and may facilitate office-based minor procedures or surgeries..
Northwestern University

Biological fluid separation device

A blood separation device adapted to receive a blood sample having a whole blood portion and a plasma portion is disclosed. The blood separation device includes a housing defining a first chamber, a second chamber, and a separation member disposed therebetween.
Becton, Dickinson And Company

Microscale plasma separator

The invention is directed to methods and devices for efficient separation of plasma irons whole blood which are suitable for point of care use in resource poor environments, in some embodiments, elements of such devices comprise (a) a sample collection receptacle (scr) with at least one port, the sample collection receptacle capable of holding a predetermined volume of a sample of undiluted whole blood drawn through a port; (b) a filter chamber having an inlet and an outlet, and containing at least one filter capable of separating plasma from blood cells as sample passes from an inlet side to an outlet side of the at least one filter whenever the filter chamber is placed in quid communication with a port of the sample collection receptacle; and (c) a manually driven pump operationally associated with the scr and filter chamber for (i) drawing a predetermined volume of sample into ore scr by a first user action and (ii) driving the predetermined volume at a substantially constant linear flow under a pressure not exceeding 2 psi from the scr through the filter chamber and the outlet of the filter chamber by a second user action.. .
Wainamics, Inc.

Blood pressure and arterial compliance estimation from arterial segments

A noninvasive method for monitoring the blood pressure and arterial compliance of a patient based on measurements of a flow velocity and a pulse wave velocity is described. An embodiment uses a photoplethysmograph and includes a method to monitor the dynamic behavior of the arterial blood flow, coupled with a hemodynamic mathematical model of the arterial blood flow motion in a fully nonlinear vessel.
Rochester Institute Of Technology

Managing insulin administration

A method includes obtaining blood glucose measurements and blood glucose times of a patient from a blood glucose meter and executing a patient management program configured to display on a screen a graphical user interface having a trend window of the blood glucose measurements on the time line. The patient management program is configured to receive, in the trend window magnifying inputs for a magnification window superimposed on a segment of the timeline to specify a date range for a magnified window.
Aseko, Inc.

Medmobile device

The medmobile device (mmd), is a medical device or circuit, software, application or app, software program, or platform, that enables a smart phone, tablet, laptop, computer, or any other mobile computer device, to take mobilized blood pressure readings, temperature readings, pulse readings, heart readings (ekg/ecg), and other vital sign readings, of a patient located outside of a heath care facility; and to monitor, track, store, process, the patient's data or information. This is accomplished by a special software app or program installed on a smart phone, tablet, computer, or any other mobile computer device, network, or platform.
Mcleanics Technology Corporation

Method for acquiring information on cause of prolongation of coagulation time, and device

The present invention relates to a method for acquiring information on a cause of prolongation of coagulation time. The present invention also relates to a device, a system and a computer program for analyzing blood coagulation..
Sysmex Corporation

Device, determining a fibrinogen level in a blood sample

The present invention relates to device (10) for determining a fibrinogen level (20) in a sample (22) comprising, a first input for obtaining an attenuance signal (24) over time indicative of a fibrin polymerization of said sample (22), a second input for obtaining a reactant concentration signal (28) over time indicative of a reactant concentration in said sample (22), wherein the reactant is any substance leading to the cleavage of fibrinogen to fibrin, a simulation unit (16) running a model (32) using the reactant concentration signal (28) as an input to provide a simulated attenuance signal (34) over time, and an evaluation unit (18) configured to infer the fibrinogen level (20) of said sample (22) by comparing the attenuance signal (24) over time with the simulated attenuance signal (34) over time.. .
Koninklijke Philips N.v.

Method and detecting vector-borne diseases in humans

Screening human subjects for vector-borne disease is provided and carried out using thymidine kinase 1 alone or in combination with c-reactive protein as biomarkers which are measured in a blood sample, and the measurements are used to compute an index that allows a practitioner to compare results from different subjects and between different populations of subjects, and the screening for vector-borne disease can also be used on subjects that are undergoing treatment to monitor the progress of an infection and the results of the treatment.. .
Veterinary Diagnostics Institute, Inc.

Whole blood measurement method associated to hematocrit (hct) and whole blood measurement circuit thereof

A whole blood measurement method associated to hematocrit (hct) and a whole blood measurement circuit thereof is applied in the detection of hct of a whole blood sample to be tested. Herein, a time to digital converting circuit (tdc) is used for counting charging time or discharging time of a fixed capacitor and a to-be-tested sample, and a capacitance difference that is related to hct is generated according to the charging time or the discharging time, so as to provide a reference for a whole blood feature test..
Holtek Semiconductor Inc.

Method and determining markers of health by analysis of blood

Biomarkers of high blood pressure are measured to identify high blood pressure of the subject based on one or more biomarkers. In many embodiments, the response of the biomarker to blood pressure occurs over the course of at least an hour, such that the high blood pressure identification is based on a cumulative effect of physiology of the subject over a period of time.
Nueon Inc.





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