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Systems and methods for medical diagnosis and biomarker identification using physiological sensors and machine learning
Predictive healthcare systems utilize the signal produced by physiological and, in some embodiments, environmental sensors to infer, computationally, a physiological parameter of the patient. The physiological sensors may include a vibro-acoustic sensor in contact with a patient over at least the frequency band 0.001 hz to 40 khz and a bio-electric sensor.

Methods and kits for labeling, detection and isolation of foxp3+ regulatory t cells, isolated population of foxp3+ regulatory t cells thus obtained and uses thereof
Disclosed is a method for labeling, detecting and/or isolating foxp3+ treg cells from a biological sample containing peripheral blood mononuclear cells (pbmc) or lymphocytes including the following steps of: (i) coupling the surface of pbmc or lymphocytes to a capture moiety which binds to the cell through a cell surface molecule and to interleukin-34 (il34), (ii) culturing the lymphocytes under conditions wherein il34 is secreted, released and specifically captured by the capture moiety, (iii) labeling the il34 expressing lymphocytes with a label moiety, and (iv) optionally detecting and/or isolating the il34 expressing lymphocytes which are foxp3+ treg cells. Also disclosed is an isolated population of foxp3+ treg cells obtainable by the method and uses thereof..
Centre Hospitalier Universitaire De Nantes


Biological fluids concentration assembly
A biological fluids concentration device, including a tube-in-tube assembly, is disclosed. The tube-in-tube assembly receives biologic fluids and may then be placed in the bucket of a centrifuge and spun to separate out the components of the biological fluid by their various densities.
Alliance Partners Llc


Pyridyl benzothiophenes as kinase inhibitors
This invention is directed to compounds, which are useful as protein kinase (pk) inhibitors and can be used to treat such diseases as cancer, blood vessel proliferative disorders, fibrotic disorders, mesangial cell proliferative disorders, metabolic diseases inflammatory disorders and neurodegenerative disorders.. .
Allergan, Inc.


Centrifuge
Centrifuges are useful to, among other things, remove red blood cells from whole blood and retain platelets and other factors in a reduced volume of plasma. Platelet rich plasma (prp) and or platelet poor plasma (ppp) can be obtained rapidly and is ready for immediate injection into the host.
Dsm Ip Assets, B.v.


Venous anatomy drug delivery balloon
Balloon catheters that deliver therapeutic agents are functional only for treatment of the arterial anatomy and result in inefficient dispersion of the therapeutic agent to the arterial tissue due to dispersion through the secondary balloon holes under high pressure. A method and drug delivery balloon device for efficient drug delivery to the targeted point of the anatomy comprising a first balloon wholly enveloped by a second balloon composed of a porous membrane that delivers the therapeutic agent to the targeted point upon the introduction of low pressure to the secondary balloon membrane.
Divergent Life Sciences Llc


Drug-eluting device for prophylaxis or treatment of a disease or pathology
The invention disclosed herein generally relates to particular intravascular drug-eluting delivery devices and methods for manufacture and use in either the prophylaxis or treatment of a disease or pathology. In one aspect, the drug eluting prosthesis is implanted into a patient's blood vessel upstream of a disease site..
Fluid Biotech Inc.


Substrate having an electron donating surface with metal particles comprising palladium on said surface
There is disclosed a substrate with an electron donating surface, characterized in having metal particles on said surface, said metal particles comprising palladium and at least one metal selected from the group consisting of gold, ruthenium, rhodium, osmium, iridium, and platinum, wherein the amount of said metal particles is from about 0.001 to about 8 μg/cm2. Examples of coated objects include contact lenses, pacemakers, pacemaker electrodes, stents, dental implants, rupture nets, rupture mesh, blood centrifuge equipment, surgical instruments, gloves, blood bags, artificial heart valves, central venous catheters, peripheral venous catheters, vascular ports, haemodialysis equipment, peritoneal dialysis equipment, plasmapheresis devices, inhalation drug delivery devices, vascular grafts, arterial grafts, cardiac assist devices, wound dressings, intermittent catheters, ecg electrodes, peripheral stents, bone replacing implants, orthopaedic implants, orthopaedic devices, tissue replacing implants, intraocular lenses, sutures, needles, drug delivery devices, endotracheal tubes, shunts, drains, suction devices, hearing aid devices, urethral medical devices, and artificial blood vessels..
Bactiguard Ab


Therapeutic pooled blood apoptotic cell preparations and uses thereof
Cell preparations comprising a pooled and enriched, mononuclear apoptotic cell population, and a method of preparing this cell preparation are described. The pooled mononuclear apoptotic cell preparation may be obtained from pooled, allogeneic white blood cell fractions that are pooled prior to or following induction of apoptosis.
Enlivex Therapeutics Ltd.


Implantable flow adjuster
An implantable flow adjuster (20) includes proximal and distal support rings (22, 24) which support a flow adjuster panel (26). The flow adjuster panel (26) divides the lumen through the device (20) into two sections, one of reducing cross sectional area and the other of increasing of increasing cross sectional area.
Cook Medical Technologies Llc


Method of removing a thrombus from a blood vessel

A method for mechanically capturing and removing a thrombus from a blood vessel includes advancing a guidewire into the thrombus. A self-expanding body is allowed to expand in the blood vessel, wherein the self-expanding body is fixed to a distal end portion of an elongate catheter.

Method of treating migraine headache using ultrasound and electrocautery or radiofrequency ablation

A method for treating headaches caused by a blood vessel irritating an associated nerve. The method is performed using a doppler ultrasound device and a treatment device (e.g., electrocautery or radiofrequency ablation).

Electronic providing blood sugar care service

An apparatus and a method for providing blood sugar care service are provided. The method includes obtaining blood sugar information of a user, when the blood sugar information is obtained for a predetermined time unit, generating a blood sugar profile based on the blood sugar information obtained during the predetermined time unit, comparing the generated blood sugar profile and a previously generated blood sugar profile, setting a blood sugar profile proximate to a normal blood sugar range as a target profile, and providing a state of blood sugar of the user based on the set target profile, thereby providing a customized blood sugar care state suitable to each user in consideration of the state of blood sugar of individuals..
Samsung Electronics Co., Ltd.

Blood glucose monitoring device and monitoring method thereof

Embodiments of the present disclosure provide a blood glucose monitoring device and a monitoring method thereof, which can reduce the influence of the oral environment on the measurement accuracy. The blood glucose monitoring device comprises: a housing; a micro-current stimulation module connected to two electrodes and generating a current, the two electrodes being located on a surface of the housing and the current stimulating the parotid gland of a user through the two electrodes to produce fresh saliva; a saliva glucose acquisition module configured to acquire a glucose concentration in the saliva; a control processing module configured to control the micro-current stimulation module to work and to obtain a blood glucose concentration value from the glucose concentration..
Boe Technology Group Co., Ltd.

Device for treatment of aneurysm

A device for treating a vascular aneurysm of a human or mammal patient, comprising an implantable member adapted to hold fluid, the implantable member being adapted to be placed against an outside of a blood vessel having the aneurysm, exercise a pressure on the aneurysm to prevent or reduce an expansion of the aneurysm, follow an outer contour of the aneurysm, and provide a pressure that is equal or less than the diastolic blood pressure of the human or mammal patient.. .

Cannula insertion detection

Sensors are disclosed that detect whether a cannula is properly inserted to its full depth in a subject's skin. The sensors may be used with a blood glucose monitor, or with a continuous insulin infusion pump, infusion set, or other system involving intermittent or continuous testing and/or drug delivery..
Becton, Dickinson And Company

Device for extraction of peaks from continuous intracranial pressure waveform and detection the same

The present invention relates to a device and a method for detecting a peak of an intracranial pressure (icp) waveform using a morphological feature of an arterial blood pressure waveform. A peak extracting method of an icp waveform using a morphological feature of an arterial blood pressure waveform according to an aspect of the present invention includes: extracting a pulse onset from a continuous icp waveform based on systolic peak from arterial blood pressure waveform; dividing individual icp waveforms in the continuous icp waveform based on the pulse onset; deriving a derivative value from each of the icp waveforms to extract a peak, a trough, and a flat; calculating latencies from the pulse onset extracted in each of the icp waveforms to the extracted peaks to cluster peaks with a similar time interval and generate a peak cluster; searching a notch from each of the icp waveforms based on the latency of a dicrotic notch of the arterial blood pressure waveform; and extracting p1, p2, and p3 peaks from each of the icp waveforms by referring to the searched notch of the icp..
Korea University Research And Business Foundation

An improved blood pressure measurement system

A blood pressure measurement system is able to measure actual blood pressures. More specifically, the blood pressure sensor or sphygmomanometer is able to detect high frequencies that exist only between systole and diastole, and thus identify aspects such as micro-pulses associated with the opening and closing of an artery to achieve accurate blood pressure readings..
A C Cossor & Son (holdings) Limited

Physiological sensor delivery device and method

An intravascular sensor delivery device for measuring a physiological parameter of a patient, such as blood pressure, within a vascular structure or passage. In some embodiments, the device can be used to measure the pressure gradient across a stenotic lesion or heart valve.
Acist Medical Systems, Inc.

Method, apparatus, and program for outputting index

A method for outputting an index for determining a condition of a blood vessel includes acquiring a diastolic blood pressure for each of upper and lower limbs of a living body, calculating a ratio of the diastolic blood pressure acquired in the acquiring step of the lower limb to the diastolic blood pressure acquired in the acquiring step of the upper limb, and outputting the ratio of the diastolic blood pressures calculated in the calculating step.. .
Nihon Kohden Corporation

Personalized pediatric nutrition products comprising human milk oligosaccharides

The present disclosure generally relates to personalized nutritional compositions for pediatric subjects, wherein the nutritional composition can include one of three distinct profiles of human milk oligosaccharides (hmos). The present disclosure also relates to methods for determining the composition of hmos present in or that would be present in the breast milk of the mother of a pediatric subject as determined by the mother's secretor status and/or lewis blood group, and providing to the pediatric subject a nutritional composition comprising an hmo profile most similar to the hmos present or that would be present in the breast milk of the subject's mother..
Mead Johnson Nutrition Company

Methods and devices for integrating analyte extraction, concentration and detection

Disclosed herein are devices and methods that use aqueous two phase systems and lateral flow assays to detect target analytes in a sample. These devices and methods may be used to diagnose a disease or condition in a biological sample, such as blood or serum.
The Regents Of The University Of California

Blood pump with separate mixed-flow and axial-flow impeller stages, components therefor and related methods

A rotordynamic pump for delivering continuous flow of fluids, such as blood, is provided. In one embodiment, the pump includes a stator housing having an inlet and an outlet.
Worldheart Corp.

Treatment of peripheral vascular disease using protein solutions

Methods of treating peripheral vascular disease comprising administering a protein solution site of a defect at least two proteins from the group il-1ra, stnf-ri, stnf-rii, igf-i, egf, hgf, pdgf-ab, pdgf-bb, vegf, tgf-β1, and sil-1rii. The solution may also comprise white blood cells, platelets, concentrated bone marrow aspirate, and combinations thereof..
Biomet Biologics,llc.

Aortic valve reconstruction training kit

A training kit is provided for practicing aortic valve reconstruction. The aortic valve reconstruction training kit is provided with a blood vessel model and multiple valve leaflet models, and the blood vessel model has a base-capped or base-uncapped cylindrical form having an opening formed on at least the top part thereof.
Japanese Organization For Medical Device Development, Inc.

Blood vessel sizing device

Medical devices and methods that provide for improved accuracy when positioning of a synthetic structure, such as a mems device or a stent, within a biological feature of a patient, such as a blood vessel, are disclosed. A blood vessel sizing device is configured for placement on the skin of a patient near a feature of interest (e.g.
Sizer Llc

Deploying and fixating an implant across an organ wall

Implant deployment device for delivering and deploying an implant. Includes: deployment device body for pushing implant in subject's blood vessel, across an interatrial septum and into subject's heart left atrium; and a handle operatively connected to deployment device and having controls assigned to selectively operate positioning of the deployment device, to facilitate determining compression extent of an implant body, and detaching of deployment device from the implant.
Vectorious Medical Technologies Ltd

Apparatus and determining blood flow velocity

Apparatus and method comprising an ultrasound transmitter, for placement at a first location on the body of a subject, to emit an ultrasound pulse; an ultrasound receiver, for placement at a second location on the body, to detect an emitted ultrasound pulse; and a controller in communication with the transmitter and receiver. The controller causes an ultrasound pulse to be emitted by the transmitter; receives a measurement signal from the receiver; determines, based on the received measurement signal, a time of arrival at the receiver, t1 s of a first part of the emitted ultrasound pulse; determines, based on the received measurement signal, a time of arrival at the receiver, t2, of a second part of the ultrasound pulse; and calculates, using t1 and t2, a flow velocity of blood in a blood vessel between the first location and the second location..
Koninklijke Philips N.v.

Medical image processing apparatus

According to one embodiment, a medical image processing apparatus includes first specifier, second specifier, determiner and display controller. First specifier collates an ischemic region calculated from a blood vessel visualized into a three-dimensional image in a plurality of phases with a dominating region of the blood vessel, and specifies a culprit vessel in the ischemic region.
Toshiba Medical Systems Corporation

User reminding method and apparatus, and terminal device

A user reminding method and apparatus, and a mobile terminal includes, obtaining, by a terminal device, a physical status of a user and a first blood pressure value of the user when a time difference between a current time and a preset reminding time is less than a first threshold; determining a first safety level based on the physical status and the first blood pressure value; and sending a first reminding signal in a manner corresponding to the first safety level.. .
Huawei Technologies Co., Ltd.

Sample handling system

A sample processing system is configured for analyzing, preprocessing, or carrying out other operations for a biological sample such as blood or urea. With the sample processing system, it is possible to store samples to be stored in a thermally insulated state or specimens required for accuracy control in the thermally insulated state for preventing evaporation or denaturing of the samples and specimens.
Hitachi High-technologies Corporation

Analyte detection and methods therefor

Disclosed are methods and systems for analyte detection in a sample and more particularly, a biological sample. Methods and systems particularly relate to differentiating and/or identifying cell types in biological samples, such as blood samples, by adding antibodies specific to predetermined cd antigens.
Orphidia Limited

Methods for complete blood count measurement

The disclosure relates to devices and methods for analyzing blood cells in a sample. In various embodiments, the present disclosure provides devices and methods of performing complete blood count (cbc) testing.
Cytochip Inc.

Lubricant regulating agent

The present invention makes the insertion perception during actual surgery to be equivalent to the insertion perception of a catheter into a blood vessel model when water is used as the circulating fluid. A lubricant regulating fluid primarily composed of water is mixed with an aqueous metal salt and a surfactant as a lubricant regulating agent of the lubricant regulating fluid.
Fain-biomedical Inc.

2-acylaminopropoanol-type glucosylceramide synthase inhibitors

Or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound represented by structural formula (i) or a pharmaceutically acceptable salt thereof.

Catheter for insertion into branched blood vessel

A branch blood vessel insertion catheter has a catheter body having a lumen penetrating therethrough from a distal end of the catheter body to a proximal end thereof to allow a guide wire to be inserted therethrough. The catheter body has an inner layer, a wire-wound reinforcing member provided on an outer surface of the inner layer, and an outer layer covering both the inner layer and the reinforcing member.
Terumo Clinical Supply Co., Ltd.

Infusion pump system and methods

Some embodiments an infusion pump system can be configured to modify alarm limit parameters as the user's insulin load increases or decreases. Moreover, in particular embodiments, the infusion pump system can be configured to provide a “missed bolus” or “missed meal” alarm in response to the user's blood glucose characteristics, the user's insulin load information, or the like..
Bigfoot Biomedical, Inc.

Dialysate free artificial kidney device

A device and method are described for the treatment of blood, which device may be used in conjunction with or in place of a failed kidney. The device includes an ultrafiltration unit to remove proteins, red and white blood cells and other high molecular weight components, a nanofiltration unit to remove glucose, at least one electrodeionization unit to transport ions from the blood stream, and a reverse osmosis unit to modulate the flow of water, to both the blood and urine streams.
Curion Research Corporation

Kits, formulations and solutions having enzymatically- permissive amounts of visualization agents and uses thereof

The invention relates to a proteolytic enzyme which is capable of forming fibrin when it reacts with fibrinogen, a fibrin-glue kit and a fibrin-glue formulation comprising an enzymatically-permissive concentration of a visualization agent and to their use in methods for prevention and/or reduction of adhesions and/or methods for promotion of blood coagulation sealing or filling body surfaces.. .
Omrix Biopharmaceuticals Ltd.

A treatment and compounds for use therein

The present invention relates generally to a method of therapeutically or prophylactically treating ischaemia-induced myocardial tissue damage, in particular ischaemia-reperfusion-induced myocardial tissue damage. More particularly, the present invention relates to a method of reducing the extent of ischaemia-induced myocardial tissue damage in a mammal by selectively upregulating fpr1-mediated erk signalling.
Monash University

Identification and use of very long chain dicarboxylic acids for disease diagnosis, chemoprevention, and treatment

A method for determining colorectal cancer risk includes obtaining a blood sample of the subject, isolating serum or edta plasma from the blood sample, analyzing the serum or edta plasma to determine plasma levels of very long chain dicarboxylic acid (vlcdca 28:4), comparing the determined plasmas level of vlcdca 28:4 of the subject with a predetermined range of plasma levels of vlcdca 28:4 of diagnosed subjects having colorectal cancer, and determining a colorectal cancer risk exists when the determined plasma level of vlcdca 28:4 is within the predetermined range of plasma levels of vlcdca.. .
Lincoln Memorial University

Methods for delivering and using a stent

Disclosed is a method, apparatus, and kit for assisting the expansion of a self-expanding stent, especially within highly curved or tortuous blood vessels. An elongated pusher having an expandable distal mesh portion can be positioned within a self-expanding stent, expanding during delivery to provide extra expansion force to the stent to ensure the stent properly expands..
Microvention, Inc.

Spiral electrode for neuromodulation therapy

Catheters having spiral electrodes and methods for their use in neuromodulation therapy. A therapeutic assembly is disposed at a distal portion of a neuromodulation catheter and is adapted to be located at a target location within a target blood vessel of a human patient.
Medtronic Ardian Luxembourg S.a.r.l.

Methods for facilitating revascularization of occlusion

This patent document discloses methods for facilitating revascularization of an occlusion in a blood vessel. A method can include engaging a first guide within a vessel wall adjacent to a distal cap of the occlusion and advancing the first guide, in a retrograde direction, to a subintimal position near a proximal cap of the occlusion.
Vascular Solutions, Inc.

Blood vessel analysis device and operating method thereof

A blood vessel analysis device includes a photoelectric detector, a processor and an ultrasonic detector. The photoelectric detector detects a blood vessel and generates a detecting signal.
National Kaohsiung University Of Applied Sciences

Micro-mechanical adjustment system for piezoelectric transducers

A system for detecting blood velocity within a blood vessel includes a transducer array including a plurality of transducers. Each of the transducers includes a carrier substrate; at least one spacer extending upwardly from substrate, a transducer element attached to spacer such that the piezoelectric transducer is spaced apart from the substrate, and setting electrodes positioned on the upper surface of the substrate under the piezoelectric transducer.
Robert Bosch Gmbh

Phased array for detecting artery location to measure blood velocity

A system for detecting artery location to measure blood velocity includes a first piezoelectric transducer array including a plurality of transducer elements, each of the transducer elements being supported on a first ceramic substrate, the first ceramic substrate having a planar lower surface configured to be placed on a surface of an area of skin of a user, the first ceramic substrate being configured to couple an ultrasonic signal emitted by the transducer elements to the skin. A phase control system is configured to supply each of the transducer elements with an electrical actuation signal, the electrical actuation signal being phase shifted for each of the transducer elements.
Robert Bosch Gmbh

Single piezoelectric transmitter and receiver to detect blood velocities

A system for detecting blood velocity within a blood vessel includes a piezoelectric transducer supported on a ceramic substrate. The ceramic substrate supports the piezoelectric transducer at a fixed angle of incidence that is greater than 0° and less than 90°.
Robert Bosch Gmbh

Medical information processing apparatus and medical information processing method

A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry acquires a first index value obtained based on fluid analysis that is performed based on an image including a blood vessel of a subject, the first index value being related to blood flow at each of positions in the blood vessel.
Toshiba Medical Systems Corporation

Medical information processing apparatus, x-ray ct apparatus, and medical information processing method

A medical information processing apparatus according to an embodiment includes processing circuitry. The processing circuitry obtains image data rendering a blood vessel of patient.
Toshiba Medical Systems Corporation

Illumination optics for a visible or infrared based viewing or imaging blood vessels

Synchronously with respect to camera frames or through user selection, switching on and off light sources which has the effect of 1) dynamically changing the overall angular distribution of light thus changing surface level reflectance; 2) revealing and through processing removing unwanted patterning caused by optical defects or contaminants on optical surfaces or surface hair; 3) moving illumination patterns to permit contrast enhancement in all areas of the surface.. .

Insulin pump based expert system

An apparatus comprising a pump configured to deliver insulin, an input configured to receive blood glucose data, a user interface, and a controller communicatively coupled to the pump, the input, and the user interface. The controller includes a blood glucose data module to compare the blood glucose data to a target blood glucose level for an insulin pump user.
Tandem Diabetes Care, Inc.

Wearable and unobtrusive multi-sensor array and pulse wave velocity imaging

Novel and advantageous systems, devices, and methods for pulse wave velocity (pwv) imaging that enable precise central blood pressure (bp) estimation are provided. A multi-sensor array can provide two-dimensional pwv, thereby achieving the pwv imaging and precise central bp estimation.
The Chinese University Of Hong Kong

Improvements in or relating to measurement of blood pressure

Disclosed is a blood pressure measurement device comprising a heat flow perfusion sensor in combination with occlusion means for restricting the flow of blood in a portion of a human or animal body.. .
Epitherm Limited

Biological signal processing device and blood pressure measurement system

An r-wave of a heartbeat signal accompanied by periodic fluctuation is detected to obtain the average value of an rr interval. Further, a waveform of a heart sound signal, which periodically fluctuates in synchronization with the heartbeat signal, is forcibly repositioned at an interval equivalent to the average value of the rr interval.
Ai Technology Inc.

Methods, systems and devices for measuring heart rate

A system and method of tracking activity includes a motion sensor, a light source and a light detector. The light detector is configured to capture an amount of the light that is reflected back to the light detector, at least a first portion of the light reflected back to the light detector is reflected from a blood vessel disposed under a skin adjacent to the housing.
Fitbit, Inc.

Blood pressure apparatus using active materials and related methods

Example blood pressure apparatus using active materials and related methods are described herein. An example apparatus includes a band to be worn around a limb of a user, an active material carried by the band and a controller to: (1) apply an activation signal to the active material to constrict blood flow in the limb, and (2) reduce the activation signal to allow blood flow in the limb..

System and angiography

The system comprises an optical fiber, a light emitting module, an ultrasound detector and an imaging system. The optical fiber has a first end and a second end.
Metal Industries Research & Development Centre

Blood pressure and cardiac monitoring system and method thereof

A blood pressure and cardiac monitoring system includes a sensing assembly, a processor, a memory, a communication interface, and any suitable computer implemented modules communicatively coupled to each other via a bus. The sensing assembly comprises of a first sensor (single or multi-axes) located at a first axis of a target generating a first time-dependent motion waveform representative of one or more contractile properties of the target's heart and a second sensor (single or multi-axes) located at a second axis of the target generating a second time dependent motion waveform representative of the target's blood flow.
Robert Bosch Gmbh

Method to recalibrate continuous glucose monitoring data on-line

In a method of recalibrating continuous glucose monitoring data from a user, operable on a digital processor, an indication from the user that the user has taken a meal is received (806). A self-monitored of blood glucose levels from the user (810) at two separate times during a day corresponding to when the user has taken a meal.
Universita Degli Studi Di Padova

Assays for detecting the presence or amount of an anti-drug antibody

Methods and kits for detecting antibodies (e.g., anti-drug antibodies). Such methods and kits permit the detection of, for example, anti-drug antibodies in human body fluids, such as blood, plasma and serum..
Genzyme Corporation

Method of differentiating stable angina pectoris from acute coronary syndrome and diagnostic kit thereof

This application discloses a method of differentiating stable angina pectoris from acute coronary syndrome, including: obtaining a blood plasma sample from a patient; measuring a relative concentration of at least one metabolic biomarker in the blood plasma sample, wherein the at least one metabolic biomarker is selected from the group consisting of malic acid, taurine, arachidonic acid, citramalic acid, methionine, and pentadecanoic acid; calculating a value according to the relative concentration of at least one metabolic biomarker; comparing the value with a predefined critical value, if the value is more than the predefined critical value, the patient has the acute coronary syndrome, otherwise, the patient has the stable angina pectoris. The method and a diagnostic kit thereof is capable of differential diagnosis of sa and acs and it can improve the diagnostic convenience and promote the diagnostic standardization..

Micro-array devices for capturing cells in blood and methods of their use

The present disclosure provides micro-array devices for capturing cells in blood and methods of their use. In some aspects, a method for counting cells in a blood sample is provided, the method comprising applying a blood sample onto a cnt device; allowing cells in the blood sample to differentially settle on the cnt device, and identifying and counting cells of preselected type in the blood sample..
University Of Louisville Research Foundation, Inc.

Blood sample testing apparatus and blood sample testing method

A blood sample testing apparatus may include: a blood-cell-count measurement unit that performs measurement of a blood sample stored in a sample container positioned in a first position; a smear preparation unit that prepares a smear of the blood sample stored in the sample container positioned in a second position; and a transport unit that transports the sample container from the first position to the second position and from the second position to the first position.. .
Sysmex Corporation

Apparatus and methods for managing blood pressure vital sign content in an electronic anesthesia record

A graphical user interface and methods for managing blood pressure vital sign content in an electronic anesthesia record on a multi-function gesture-sensitive device via gesture-based means. The graphical user interface and methods give an improved user interface and set of functions via novel functions unique to gesture sensitive interfaces..

Method for determining genetic condition of fetus

Provided is a method for determining a genetic condition of a fetus, the method including: an objective region selection step of selecting an objective region for determining the genetic condition, from regions on a human genome; a step of isolating a single cell from a maternal blood sample; a step of extracting genomic dna from the single cell; a step of performing pcr amplification on the objective region using a primer set designed so as to perform the pcr amplification on the objective region using genomic dna extracted from the single cell as a template; and a dna sequencing step of decoding a dna base sequence of a pcr amplification product of the objective region, in which the primer set designed so as to perform the pcr amplification on the objective region is designed through a method for designing a primer set used for the polymerase chain reaction, the method for designing a primer set including a first stage selection step based on a local alignment score and a second stage selection step based on a global alignment score.. .
Fujifilm Corporation

Maximizing dna yield of blood specimens collected in rapid clot tubes

The invention provides methods for isolating dna from a blood sample collected into tubes containing a rapid clot activator, which involves the use of a lysis buffer comprising an alcohol.. .
Abbott Molecular Inc.

Method of extraction of genomic dna for molecular diagnostics and application

Methods and systems for extracting dna from a sample are provided. A method includes: lysing red blood cells of the sample using a first solution; dissolving lipids of cellular membranes in the sample using a second solution; and releasing dna of the sample into a buffer using a third solution..
Pzm Diagnostics, Llc

Measurement unbound bilirubin in blood sample

Provided is a measurement method whereby the amount of unbound bilirubin (ub) can be exactly reflected whether a specimen contains a large amount of conjugated bilirubin or not. The measurement method for ub according to the present invention comprises decomposition step (i), decomposition stopping step (ii), contact step (iii) and detection step (iv).
National University Corporation Kobe University

Medicine injection and disease management systems, devices, and methods

One or more embodiments of the present disclosure may include an insulin delivery system that includes an insulin delivery device, a user interface that includes multiple user-selectable icons or buttons each representing different meal characteristics, memory to store one or more user-specific dosage parameter, and a processor in communication with the memory and adapted to receive blood glucose data. The processor may also be adapted to determine initial meal characteristics associated with each of the user-selectable icons or buttons based on at least one of the user-specific dosage parameters.
Bigfoot Biomedical, Inc.

Stent planning systems and methods using vessel representation

In part, the disclosure relates to determining a stent deployment location and other parameters using blood vessel data. Stent deployment can be planned such that the amount of blood flow restored from stenting relative to an unstented vessel increases one or more metrics.
Lightlab Imaging, Inc.

Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods

Catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present technology, for example, is directed to a treatment device having a multi-electrode array configured to be delivered to a renal blood vessel.
Medtronic Ardian Luxembourg S.a.r.l.

Artery medical apparatus and methods of use thereof

Methods and medical apparatus for deployment within an anatomical blood vessel. The medical apparatuses comprising: a first tubular wall, a second tubular wall, within the first tubular wall, and a constricting element configured to constrict a circumference of a portion of the second tubular wall; the combination of the first tubular wall, the second tubular wall and the constricting element forms a diametrical reducer..
Restore Medical Ltd

Blood flow reducer and method using the same

A blood flow reducer (20) for insertion in a blood vessel, the reducer (20) being adapted to be deformed from a first configuration to an expanded configuration, wherein, in the expanded configuration, the reducer (20) defines an axial lumen (40) for allowing blood flow therethrough, the axial lumen (40) having a smallest cross-section, the reducer (20) has a largest cross-section, and the smallest cross-section is comprised between 20% and 90% of the largest cross-section. In particular, the smallest cross-section is strictly comprised between 70% and 90% of the largest cross-section.
Institut National De La SantÉ Et De La Recherche MÉdicale

Large bore vascular closure system

A vascular closure system for sealing an opening in a blood vessel may include an introducer sheath extending through the opening, the introducer sheath having a lumen extending through the introducer sheath, wherein partial withdrawal of the introducer sheath from the opening everts tissue of the blood vessel at the opening, and a shaping sheath slidably disposed over the introducer sheath, the shaping sheath having a split distal portion configured to engage the everted tissue.. .
Boston Scientific Scimed, Inc.

Smart wearable device for health watch

A wearable device comprising a display dial configured to display various health parameters, a wristband assisting the device to wear on wrist, an eject-able tray comprising a micro-chip, a first spring coupled to the eject-able tray, at least one latch provided with a second spring to hold the eject-able tray within the device by compressing the first spring, and a health monitoring unit provided with multiple sensors to determine various health parameters, wherein compression of the second spring results in the latch to release the eject-able tray which in turn relaxes the compressed first spring to eject the micro-chip outside the device for collecting blood samples. The microchip comprises at least one micro-needle and an enzyme test strip for collecting and analyzing the blood samples.
Sensesemi Technologies Private Limited

Detecting apparatus based on image for blood glucose concentration and method thereof

The present invention provides a detecting apparatus based on image for detecting blood glucose concentration and method thereof. The detecting apparatus comprising a lighting device, an image capture device, a thermal imager and an operating device.
National Applied Research Laboratories

System and physiological parameter monitoring

A device (110), method and system (100) for calculating, estimating, or monitoring the blood pressure of a subject are disclosed. A first signal representing heart activity of a subject may be received.
Vita-course Technologies Co., Ltd.

System and blood pressure monitoring

A device (110), method and system (100) for calculating, estimating, or monitoring the blood pressure of a subject. At least one processor, when executing instructions, may perform one or more of the following operations.
Vita-course Technologies Co., Ltd.

Monitoring device and operating the same

A device for radiating pulsed light toward a thrombus in a blood vessel includes a light source configured to output monitoring light to be radiated into the blood vessel, a light detector configured to detect returned light of the monitoring light and output a detection signal, and a computer configured to acquire a time waveform, which is a change in an intensity of the returned light over time, based on the detection signal, wherein the computer is configured to obtain a parameter on the basis of the time waveform and evaluates a reaction in the blood vessel according to the radiation of the pulsed light on the basis of the parameter.. .
Hamamatsu Photonics K.k.

Method and system for registering ultrasound and computed tomography images

A method for registering ultrasound (us) and computed tomography (ct) images, comprising: receiving us and ct images representative of a body portion comprising blood vessels and an initial approximate transform; enhancing the blood vessels in the us and ct images, thereby obtaining an enhanced us and ct images; creating a point-set for a given one of the enhanced us and ct images; determining a final transform between the point-set and the other one of the enhanced us and ct images using the initial transform; applying the final transform to a given one of the us and ct images to align together a coordinate system of the us image and a coordinate system of the ct image, thereby obtaining a transformed image; and outputting the transformed image.. .
The University Of Western Ontario

Device for providing health information and advice to shoppers

A product assistant device may attach to a shopping cart or other baggage cart and provide information and guidance on products within a retail space. The assistant device may provide physiological information from sensors such as heart rate, blood pressure, or other non-invasively measured characteristics via a display.
Ach Food Companies, Inc.

Automatic analysis device and automatic analysis method

The automatic analysis device 100 is provided with: a specimen dispensing mechanism 101 that dispenses subject blood plasma and/or normal blood plasma to be added to correct the coagulation time of the subject blood plasma, into a plurality of specimen containers 103; reaction containers 104 that contain the subject blood plasma and/or the normal blood plasma; a reagent dispensing mechanism 106 that dispenses a reagent into the reaction containers 104; and a detecting unit 113 which applies light from a light source 115 to the subject blood plasma and/or the normal blood plasma to which the reagent is added in the reaction containers 104, and which measures the coagulation time on the basis of the obtained scattered light and/or transmitted light.. .
Hitachi High-technologies Corporation

Method for diagnosing diseases through oligomer analysis of abnormally aggregated proteins

The present invention relates to a method for diagnosing a disease using an analysis of oligomer of an abnormal aggregated protein includes: (1) preparing a body fluid sample including at least one of blood, blood plasma, blood serum, saliva, urine, tear, and mucus; (2) making a dilution of the body fluid sample; (3) using a biosensor to measure and detect an aggregated protein in the diluted body fluid sample; (4) analyzing a signal change of the biosensor caused by the dilution of the aggregated protein to determine a slope according to the dilution from the measurements; and (5) analyzing a proportion of the oligomer from the slope according to the dilution to make a diagnosis. The method uses a biosensor to measure the impedance and the protein concentration of blood and detects the slope according to the numerical value of the monomer and the oligomer to diagnose normal or abnormal protein aggregation or the associated diseases with more accuracy..
Korea Institute Of Science And Technology

Biomarker for diagnosis of extrahepatic bile duct carcinoma, intrahepatic bile duct carcinoma, or gallbladder carcinoma

When the concentration of ceacam1 in a blood sample collected from a test subject is detected using a kit for diagnosis comprising an antibody specifically binding to ceacam1 or a labeled product thereof, or the like and the ceacam1 concentration is higher than the concentration of ceacam1 in a blood sample derived from a non-carcinoma control subject or higher than a certain threshold value (cutoff value), data can be collected for diagnosing the test subject as having a high possibility of having extrahepatic bile duct carcinoma, intrahepatic bile duct carcinoma, or gallbladder carcinoma.. .

Electrical characteristic measurement device, electrical characteristic measurement method, blood condition analysis system, and electrical characteristic measurement program for causing computer to execute the method

A technology of measuring an electrical characteristic of a blood sample is provided that allows easy introduction, into an existing blood test system, a technique of obtaining information on a blood sample from an electrical characteristic of the blood sample. The technology provides a device for measuring an electrical characteristic of a blood sample, the device including: a mixing unit configured to mix a blood cell component and a plasma component on the basis of the composition ratio between the blood cell component and the plasma component in a blood sample; and a blood sample measurement unit configured to measure an electrical characteristic of a blood sample obtained by mixing by the mixing unit..
Sony Corporation

Analyte determination method and analyte meter

The presence of oxygen or red blood cells in a sample applied to an electrochemical test strip that makes use of a reduced mediator is corrected for by an additive correction factor that is determined as a function of the temperature of the sample and a measurement that reflects the oxygen carrying capacity of the sample. The measured oxygen carrying capacity can also be used to determine hematocrit and to distinguish between blood samples and control solutions applied to a test strip..
Agamatrix, Inc.

Process of separating blood plasma/serum from whole blood

The invention relates to whole blood filter media and a process of filtering whole blood samples using a filter medium comprising particles, wherein the blood cells are retained inside the filter, and wherein the plasma or serum is separated from the blood cells.. .
Mann+hummel Gmbh

Vascular access system with connector

A connector for fluidly coupling proximal and distal tubular segments of a fluid conduit is provided. In one embodiment, a system is provided for providing continuous flow of blood between two locations in a patient's cardiovascular system.
Merit Medical Systems, Inc.

Dietary supplements containing dehydrated strawberry

Compositions and processes are disclosed for a capsule, tablet, or pill comprised of powdered strawberries. Fresh strawberries are washed, de-calyxed, and then processed into a dry pulp.

Systems and methods for deriving and collecting platelet products

Systems and methods are provided for deriving a platelet product from a plurality of buffy coats. A plurality of buffy coats are separately collected, for example, using a conventional floor centrifuge.
Fenwal, Inc.

Methods for treating hemolytic diseases and sickle cell disease

The present disclosure generally relates to methods of treating hemolytic diseases such as sickle cell anemia using kinase inhibitors, for example, compounds that inhibit the spleen tyrosine kinase (syk). In some embodiments a method is presented to prevent thrombosis in blood vessels of patients with a hemolytic disease comprising the step of: administrating to a patient having at least one hemolytic disease a therapeutically effective amount of at least one syk inhibitor.
Purdue Research Foundation Office Of Technology Commercialization

Prosthetic heart valve

A prosthetic heart valve includes a valve frame (2), on which a plurality of valve leaflets (8) are fixed, and a fastening area for fastening in a blood vessel, which axially adjoins the valve frame (2). A stabilizing ring (14) is arranged in the fastening area.

Heart valve prosthesis

A heart valve prosthesis includes a downstream first axial end (6) and an upstream second axial end (8) and a stitching ring (10) extending in an arcuate manner for stitching in a blood vessel. The arcuate course of the stitching ring (10) is formed by three arcs (12) and three transition regions (14).

System and mapping the functional nerves innervating the wall of arteries, 3-d mapping and catheters for same

Disclosed herein are systems and methods for locating and identifying nerves innervating the wall of arteries such as the renal artery. The present invention identifies areas on vessel walls that are innervated with nerves; provides indication on whether energy is delivered accurately to a targeted nerve; and provides immediate post-procedural assessment of the effect of energy delivered to the nerve.
Symap Medical (suzhou), Limited

C-arm field generating removing material from blood vessel walls

Systems and methods for removing plaque from blood vessels by applying constant or time varying magnetic or electrical fields. In one embodiment a system includes winding configurations positioned about a central axis along which a body region may be placed.
Advanced Magnet Lab, Inc.

Method and system for monitoring blood pressure

A system for monitoring blood pressure includes a blood pressure cuff, a blood pressure measurement device removably connected to the blood pressure cuff, and a cuff verification module. The cuff verification module is executable on a processor to receive medical record information from a patient, determine an expected cuff size for the patient based on the medical record information, receive a detected cuff size for the blood pressure cuff, and verify that the detected cuff size is consistent with the expected cuff size..
General Electric Company

Blood pressure calculation method based on pulse return wave transmission time, and blood pressure monitor

A method for calculating blood pressure based on pulse return wave transmission time, and a blood pressure monitor have been provided. The method includes the following steps: s1: collecting and storing pulse waveform data at a fingertip; s2: processing said pulse waveform data to obtain a heart rate and parameters of a plurality of pulse periods, detecting time axis coordinates of a primary wave starting point spl1 of a pulse wave and a growth point spl2 of a return wave in each of said pulse periods, and calculating a corresponding pulse return wave transmission time rwtt: rwtt=spl2−spl1; s3: calculating the pulse return wave transmission time rwtt in each of said pulse periods to form a rwtt array; and s4: calculating systolic and diastolic pressures based on said rwtt array and the heart rate..
Hangzhou Nanochap Electronics Co., Ltd.

Blood pressure measurement data processing method and apparatus

A blood pressure measurement data processing method includes obtaining first calibration data of a user and pre-stored second calibration data of the user; determining, according to the first calibration data and the second calibration data, an optimal function used to represent a function relationship between a pulse wave transmission time and a blood pressure value of the user; obtaining a current pulse wave transmission time of the user; and calculating a current blood pressure value of the user according to the current pulse wave transmission time and the optimal function.. .
Huawei Technologies Co., Ltd.

Multi-model blood pressure estimation

One aspect of the subject matter described in this disclosure can be implemented in a device capable of use in estimating blood pressure. The device includes one or more arterial sensors configured to obtain arterial measurements at two or more elevations.
Qualcomm Incorporated

Wearable blood pressure monitoring system

An apparatus includes one or more memories storing computer readable code and processor(s). The processor(s), in response to loading and executing the computer readable code, cause the apparatus to perform operations including receiving electrocardiogram data from an electrocardiogram sensor.
International Business Machines Corporation

Wearable blood pressure monitoring system

An apparatus includes one or more memories storing computer readable code and processor(s). The processor(s), in response to loading and executing the computer readable code, cause the apparatus to perform operations including receiving electrocardiogram data from an electrocardiogram sensor.
International Business Machines Corporation

Renal therapy machine and system with blood pressure monitor

A renal therapy machine with a blood pressure monitor is disclosed. In an example, a renal therapy machine includes a dialysis fluid pump a control processor for controlling a treatment performed by the dialysis fluid pump, and a user interface in operable communication with the control processor.
Baxter Healthcare Sa

Method and establishing a blood pressure model and determining a blood pressure

The embodiments of the present disclosure disclose a method and apparatus for establishing a blood pressure model. The method comprises: acquiring pulse wave data, electrocardiographic data, blood pressure data and body mass indexes of a plurality of subjects to be examined; determining pulse wave transit time and pulse wave intensity ratios based on the pulse wave data and the electrocardiographic data; establishing a blood pressure model based on the blood pressure data, the pulse wave transit time, the pulse wave intensity ratios, and/or the body mass index..
Boe Technology Group Co., Ltd.

Method of detecting platelet activating antibodies that cause heparin-induced thrombocytopenia/thrombosis

The present invention provides a method of detecting platelet activation in a patient, the method comprising the steps of a) obtaining a blood sample from a patient suspected of having heparin-induced thrombocytopenia (hit); b) incubating an effective amount of platelet factor 4 (pf4) with a sample of platelets to yield a sample of pf4-treated platelets; c) contacting the patient blood sample with the pf4-treated platelets; and d) measuring the extent of platelet activation, wherein an increase in platelet activation compared with results obtained using a normal blood sample is indicative of the patient having hit.. .
Blood Center Research Foundation

Method for measuring glycemic index of human-consumed food

The glycemic index is determined based on the results of blood glucose concentration measurements by evaluating time Δt from the beginning of food-related increase of blood glucose concentration until the peak of glucose concentration is reached, after which maximum increase Δgmax of said glucose concentration is determined over the given period of time. Thereat, the glycemic index of food is defined as a ratio of maximum increase of blood glucose concentration Δgmax versus maximum increase of said glucose concentration in case of pure glucose intake in the amount equal to carbohydrate content of the consumed food, which is proportional to the product of Δgmax by Δt.
Healbe Corporation

Devices and methods for filtering blood plasma

The present invention provides systems, devices, kits, and methods for separating blood plasma from whole blood. In particular, the present invention provides systems, devices, and methods for separating a fixed volume of blood plasma from whole blood with minimal energy input..
Northwestern University

Electrical measurement method, electrical measurement device, and blood condition analysis system

Provided is a technique that allows high-accuracy electrical measurement without the influence of blood sedimentation in a case where various measurements or evaluations are performed using blood samples containing a blood cell component and a plasma component. Provided is an electrical measurement method for electrically measuring a blood sample including at least a blood cell component and a plasma component, the electrical measurement method including the step of adding a blood sedimentation inhibitor to the blood sample.
Sony Corporation

Vascularized skin models

A synthetic skin tissue is served by at least one synthetic blood vessel and includes a physiologically representative population of cells including fibroblasts and keratinocytes, wherein some keratinocytes are in a differentiated state.. .
The Government Of The United States Of America, As Represented By The Secretary Of The Navy

Tfpi inhibitors and methods of use

The invention provides peptides that bind tissue factor pathway inhibitor (tfpi), including tfpi-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a tfpi, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, and/or treat a blood coagulation disorder in a subject..
Baxalta Incorporated

Bioactive glass scaffolds, and making

A glass, glass-ceramic, or ceramic bead is described, with an internal porous scaffold microstructure that is surrounded by an amorphous shield. The shield serves to protect the internal porous microstructure of the shield while increasing the overall strength of the porous microstructure and improve the flowability of the beads either by themselves or in devices such as biologically degradable putty that would be used in bone or soft tissue augmentation or regeneration.
Mo Sci, Corp.

Endonuclease targeting blood coagulation factor viii gene and composition for treating hemophilia comprising same

The present invention provides a method for inducing an inversion of normal blood coagulation factor viii (f8) gene, a method for correcting an inversion of blood coagulation factor viii gene in which the inversion has occurred, and a hemophilia a patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the f8 gene, which is responsible for the majority of severe hemophilia a, and thereby may be effectively used for studying the development mechanism of hemophilia a and as a research tool for screening therapeutic agents.
Institute For Basic Science

Herbal supplement ''optimal cholesterol''

“optimal cholesterol” utilizes edible nature plant extracted by a variety of technology, it is one of the nature plant medicines which can treat atherosclerotic coronary heart disease, cerebral vascular disease and systemic vascular disease in the world. Its function is to soften the arterial blood vessels, and to treat arteriosclerosis, protect and repair the vascular endothelial cells; soft plaque, fibrous plaque and calcified plaque are removed during the process of preventing plaque rupture, bleeding, erosion and ulcer; regulate micro-circulation, enhance the ability of coronary artery blood supply, adjust heart rate, furthermore, there's none toxic side effects after long-term use..

Medical stent

In an embodiment, a stent is provided for use in blood vessels with blockage near or in a bifurcation. The stent includes a side aperture.
Rbkpark Llc

Aneurysm treatment method

A method for treating an aneurysm with at least one branch blood vessel branched from a diseased aorta comprises implanting an aortic stent graft and an auxiliary stent into a diseased blood vessel to isolate the aneurysm, wherein the auxiliary stent comprises a bifurcated stent graft, one end of the aortic stent graft is attached to the wall of a healthy blood vessel upstream of the aneurysm, and the auxiliary stent comprises a body portion and a branch portion communicated with the body portion, one end of the body portion is communicated with a healthy blood vessel downstream of the aneurysm, the other end of the body portion is communicated with the aortic stent graft, and the branch portion is suspended within the diseased blood vessel. A straight stent graft is advanced towards the branch portion from the location downstream of the bifurcated stent graft and deployed to communicate the branch portion and the branch blood vessel..
Lifetech Scientific (shenzhen) Co., Ltd.

Ultrasound catheter

A system and a method for disrupting an occlusion within a blood vessel is provided the system includes an elongated catheter body having a proximal portion, a distal portion, and a first lumen. The system further includes an ultrasound transmitter extending longitudinally through the first lumen of the catheter body and having a proximal end and a distal end.
Indiana University Research & Technology Corporation

Arterial wall compression stent

A compression stent for applying a localized high stress against a blood vessel wall to cause vessel wall compression and blockage of sympathetic and nerve signal transmission within the wall of a blood vessel. The compression stent can also sever nerves located in the vessel wall.

Biodegradable blood vessel occlusion and narrowing

A biodegradable blood vessel narrowing device, comprising: a biodegradable element; an anchoring element; wherein said anchoring element is anchored to a blood vessel wall and at least one external dimension of said biodegradable element is reduced upon biodegradation of said biodegradable element thereby pulling said blood vessel walls toward one another.. .
V.v.t. Med Ltd.

Ultrasonic diagnostic device

The present invention, relates to an ultrasonic diagnostic device that simultaneously displays an imt and the elastic indices of a blood vessel to determine, the risk for developing arteriosclerosis. The ultrasonic diagnostic device includes: an ultrasonic probe that transmits ultrasound to a body and receives ultrasonic echo to output a reception signal; image data generation mechanism that generates, based on the reception signal, image data representing an ultrasonic image on a blood vessel of the body; imt measurement mechanism that measures, based on the image data, an imt of the blood vessel; elastic index measurement mechanism that determines, based on the image data, a value representing an elastic index of the blood vessel; and a display that displays a two-dimensional coordinate system in which the imt is represented on a first coordinate axis and the value representing the elastic index of the blood vessel is represented on a second coordinate axis..
Fujifilm Corporation

Blood pressure measuring device and blood pressure measuring method using the same

There is provided a blood pressure measuring device comprising: a first heart rate measuring module configured to measure a first heart rate at a first location of an examinee's body; a second heart rate measuring module configured to measure a second heart rate at a second location of the examinee's body, wherein the first location is different from the second location, wherein a first spacing between the first location and a heart of the examinee is different from a second spacing between the second location and the heart of the examinee; and a blood pressure estimation module configured to estimate a blood pressure of the examinee based on the first and second heart rates measured by the first and second heart rate measuring modules.. .
Gwangju Institute Of Science And Technology

Non-invasive nanosensor system to determine analyte concentration in blood and/or bodily fluids.

The device is an ultra-low power, non-invasive in-vivo blood analyte sensor system incorporating multiple sensors including a carbon base and/or carbon base material coated with metallic nanoparticles and/or metallic nanoparticle nanoprobes, as a modified clark electrode sensor system, that detects hydrogen peroxide concentrations, ph, and/or glucose concentrations (and other analytes) in bodily secretions (e.g. Tears, saliva, sweat).

Blood pressure measuring device

Disclosed herein is a blood pressure measuring device including: a pressure measuring tool 110; a fastening member 120 configured to fasten the pressure measuring tool 110 in rest position onto a skin region covering an anastomotic region of a shunt blood vessel 201; and a control circuit 130 configured to receive an input signal from the pressure measuring tool 110 and to process the input signal to calculate a pressure inside the anastomotic region of the shunt blood vessel 201.. .
Nipro Corporation

Method and measuring blood pressure

According to an aspect, there is provided an apparatus for measuring the blood pressure, bp, of a user, the apparatus comprising a volume-clamp bp monitoring device that comprises a first pressure device for applying pressure to a first part of the body of the user, a first photoplethysmogram, ppg, sensor for obtaining a first ppg signal from the first part of the body of the user, and a control unit that is configured to analyse the first ppg signal and to control the pressure of the first pressure device; wherein the control unit is configured to adjust the pressure of the first pressure device to maintain the first ppg signal at a constant level and to determine the bp of the user from the pressure of the first pressure device; and a second sensor, separate from the first ppg sensor, for measuring a physiological characteristic of the user in a second part of the body of the user, wherein the second part of the body is separate from the first part of the body; wherein the apparatus is configured to analyse the measured physiological characteristic to determine a measure of the blood perfusion in the second part of the body of the user, and to determine whether to perform a recalibration of the volume-clamp bp monitoring device on the basis of changes in the blood perfusion.. .
Koninklijke Philips N.v.

Tube for blood pressure cuff and blood pressure cuff

A tube for a blood pressure cuff includes a hollow and long shape, and plural projection portions projecting toward a center of a regular polygon in correspondence with vertices of the regular polygon which inscribes in an outer circumference and has 5 or more angles, in a shape of an inner circumference in a cross section perpendicular to a longitudinal direction of the cuff tube.. .
Nihon Kohden Corporation

Device for acquiring physiological variables measured in a body

An eavesdropping arrangement for acquiring a measured physiological variable of an individual includes a receiver and a communication interface in a housing separate from the receiver. The communication interface is positioned along a communication link between a first sensor, which is configured to measure aortic blood pressure and to provide a signal representing measured aortic blood pressure, and a central monitoring device configured to monitor the measured aortic blood pressure.
St. Jude Medical Coordination Center Bvba

Ophthalmic imaging apparatus and ophthalmic image processing apparatus

An ophthalmic imaging apparatus of an embodiment includes a data acquisition unit, a blood vessel enhanced image forming unit, and a blood vessel gradient distribution determination unit. The data acquisition unit is configured to acquire a three dimensional data set of a fundus of a subject's eye using optical coherence tomography (oct).
Topcon Corporation

Systems and methods for risk assessment and treatment planning of arterio-venous malformation

A computer implemented method for assessing an arterio-venous malformation (avm) may include, for example, receiving a patient-specific model of a portion of an anatomy of a patient; using a computer processor to analyze the patient-specific model for identifying one or more blood vessels associated with the avm, in the patient-specific model; and estimating a risk of an undesirable outcome caused by the avm, by performing computer simulations of blood flow through the one or more blood vessels associated with the avm in the patient-specific model.. .
Heartflow, Inc.

Multi-step vessel segmentation and analysis

Multi-step vessel segmentation and analysis is provided. In various embodiments, a branch detection algorithm is applied to a medical image to determine a plurality of branches of a blood vessel appearing in the medical image.
International Business Machines Corporation

Diagnostics systems and methods

A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample.
Hemex Health, Inc.

Pressure sensor, acoustic microphone, blood pressure sensor, and touch panel

According to one embodiment, a pressure sensor includes a film part, and a sensing unit. A circumscribing rectangle circumscribing a configuration of a film surface of the film part has a first side, a second side, a third side connected to one end of the first side and one end of the second side, a fourth side connected to one other end of the first side and one other end of the second side, and a centroid of the circumscribing rectangle.
Kabushiki Kaisha Toshiba

Rotary blood pump with opposing spindle magnets, bore and drive windings

Various “contactless” bearing mechanisms including hydrodynamic and magnetic bearings are provided for a rotary pump as alternatives to mechanical contact bearings. In one embodiment, a pump apparatus includes a pump housing defining a pumping chamber.
Tc1 Llc

System for extended storage of red blood cells and methods of use

A system and methodology for the preservation of red blood cells is described in which red blood cells are oxygen or oxygen and carbon dioxide depleted, treated and are stored in an anaerobic environment to optimize preparation for transfusion. More particularly, a system and method for extended storage of red blood cells from collection to transfusion that optimizes red blood cells prior to transfusion is described..
New Health Sciences, Inc.

Implantable meshes for controlling the movement of fluids

Meshes for use to control the movement of bodily fluids, such as blood, are described herein. The mesh can be partially or completely biodegradable or non-biodegradable.
Arch Biosurgery, Inc.

Composite with the function of regulating blood glucose

A composite with the function of regulating blood glucose is formed into a tablet by clustering and mixing bitter gourd extract, olive extract, cinnamon extract, zinc gluconate, and chromium yeast. Animal experiment results clearly show that diabetic patients have significant improvements by taking a blood glucose regulating tablet with the compound recipe of the composite..

Automated retrievable hemorrhage control system

Some implementations of an endovascular device include a stent graft with an expandable tubular metallic frame and a covering material disposed on at least a portion of the metallic frame. The stent graft defines a lumen therethrough.
Board Of Regents Of The University Of Nebraska

Device for regulating blood flow

An implantable device for regulating blood flow through a blood vessel comprising an elongated support dimensioned and configured to be implanted in a blood vessel. The support includes a linking member linking axially spaced apart portions to one another.
Deep Vein Medical, Inc.

Vessel dissection and harvesting apparatus, systems and methods

Apparatus, systems, and methods for endoscopic dissection of blood vessels and control over cavity pressure within an endoscopic procedure are described herein. Apparatus, systems, and methods for harvesting of blood vessels are also described herein..
Mayo Foundation For Medical Education And Research

Modeling blood-brain barrier in vitro

Synthetic human blood vessels can be constructed using human brain derived endothelial cells and incorporated into a tissue model that contains astrocytes and other neurons and microglia. Multi-cell type microvessels incorporate cell types such as astrocytes and pericytes in order to construct a highly representative blood-brain barrier in vitro model with a functional lumen containing brain-derived microvascular endothelial cells and a polymer wall containing human astrocytes and/or pericytes..
The Government Of The United States Of America, As Represented By The Secretary Of The Navy

Simultaneous rotating separator, irrigator microcatheter for thrombectomy

The described invention provides several aspects designed to help mechanically break up a clot inside vessels and/or remove a clot via aspiration simultaneously. According to some embodiments, the devices are adapted to irrigate a blood vessel during thrombectomy; to macerate an obstruction during thrombectomy, to block blood flow in a blood vessel during aspiration of a thrombus; or to capture and remove distal emboli.

Atherectomy devices and methods

This document describes rotational atherectomy devices and systems for removing or reducing stenotic lesions in blood vessels by rotating an abrasive element within the vessel to partially or completely remove the stenotic lesion material.. .
Cardio Flow, Inc.

Rotating separator, irrigator microcatheter for thrombectomy

The described invention provides several aspects designed to help mechanically break up and/or lyse a clot inside vessels and/or remove a clot via aspiration. According to some embodiments, the devices are adapted to irrigate a blood vessel during thrombectomy; to macerate an obstruction during thrombectomy, to block blood flow in a blood vessel during aspiration of a thrombus; or to capture distal emboli..

Diagnostics systems and methods

A point-of-care diagnostic system that includes a cartridge and a reader. The cartridge can contain a patient sample, such as a blood sample.
Hemex Health, Inc.

Multispot monitoring for use in optical coherence tomography

Optical coherence tomography (herein “oct”) based analyte monitoring systems are disclosed. In one aspect, techniques are disclosed that can identify fluid flow in vivo (e.g., blood flow), which can act as a metric for gauging the extent of blood perfusion in tissue.
Masimo Corporation

Device and spectrum analysis and device for blood glucose measurement

A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra..
Samsung Electronics Co., Ltd.

System to diagnose and manage orthostatic intolerance

An apparatus includes a posture sensing circuit configured to detect a change in posture of a subject; a cardiac signal sensing circuit configured to generate a sensed cardiac signal, wherein the sensed cardiac signal includes heart rate information of the subject; a physiologic sensing circuit configured to generate a sensed physiologic signal, wherein the physiologic signal includes information related to blood pressure of the subject; a storage buffer; and a control circuit operatively coupled to the posture sensing circuit and the storage buffer. The control circuit is configured to initiate storage of the heart rate information and the information related to blood pressure in response to a detected change in posture of the subject..
Cardiac Pacemakers, Inc.

Photo-acoustic sensing apparatus and methods of operation thereof

A photo-acoustic sensing apparatus (100) for non-invasive measurement of blood parameters of a subject (102) comprises a photo-acoustic sensor (104) for sensing photo-acoustic signals (106) induced when a region of the subject is illuminated by a light source (108). A first sensor processing module (112) may derive blood oxygen saturation using sensed photo-acoustic signals (114).
Nanyang Technological University

Ophthalmic analysis apparatus and ophthalmic analysis method

An ophthalmic analysis apparatus for analyzing oct motion contrast (mc) image data of a subject's eye acquired using an oct apparatus for ophthalmology includes analysis process means for analyzing the oct mc image data, in which the analysis process means generates oct blood vessel change data including temporal change information in relation to a blood vessel region of the subject's eye based on first oct mc image data and second oct mc image data acquired at mutually different times.. .
Nidek Co., Ltd.

Hydrogel structure, blood vessel, internal organ model, practice tool for medical procedure, and manufacturing the hydrogel structure

A hydrogel structure includes a hollow tubular structure having an inner diameter of 1.0 mm or less, wherein the hydrogel structure has a transmission of 80 percent or more in a visible light range.. .

Network topology for insulin pump systems

In one implementation, an insulin delivery system using an on-body network includes an insulin delivery device that is adapted to administer dosages of insulin to a patient; a controller that is adapted to control operation of the insulin delivery device, to establish a first network connection in which the controller acts in a central role, and to establish a second network connection in which the controller acts in a peripheral role; one or more peripheral devices that are adapted to generate patient data related to blood glucose levels and to transmit the patient data wirelessly over the first network connection, the peripheral devices acting in a peripheral role over the first network connection; and a mobile application installed on a mobile computing device that is programmed to communicate with the controller over the second network connection, the mobile application communicating in a central role over the second network connection.. .
Bigfoot Biomedical, Inc.

Devices, systems, and methods for physiology monitoring

Software applications, devices, systems, and methods are provided for monitoring, recording, and tracking cardiac health related metrics using an associated computing device. The software applications may monitor, record, and track physiological data such as cardiac electrical activity, heart rate, and blood pressure.
Alivecor, Inc.

Controlled blood delivery to mixing chamber of a blood testing cartridge

Embodiments of a blood coagulation testing system can operate as an automated thromboelastometry system that is particularly useful, for example, at a point-of-care site. In some embodiments, the blood coagulation testing system includes a single-use cartridge component configured to measure and mix reagents with blood received from a blood sample reservoir.
C A Casyso Ag

Pump with external controlled compression and methods of pumping with external controlled compression

The present invention relates to pumps, particularly a compact, linear, positive displacement pump that can be used in several applications including medical and non-medical devices. In particular, the invention is related to linear, positive displacement compression blood pumps (either intracorporeal or extracorporeal) that provide systemic circulatory stability by maintaining a steady average blood pressure.
The Regents Of The University Of Colorado, A Body Corporate

Digital analysis of circulating tumor cells in blood samples

This disclosure relates to new assay methods for analysis of circulating tumor cells (ctcs) in blood samples for detection, e.g., early detection, and/or monitoring of disease, e.g., cancer. The methods provide ultra-high sensitivity and specificity, and include the use of microfluidic isolation of ctcs and digital detection of rna derived from the ctcs..
The General Hospital Corporation

Blood rna biomarkers of coronary artery disease

The present invention discloses a unique panel of gene transcripts down-regulated in patients with coronary artery disease (cad). Methods and compositions for detecting cad in patient blood samples are provided..
The George Washington University

Autologous somatic cell therapy, controllable preparation of therapeutic composition and procedure of adaptive treatment of ivf patient

A blood product containing peripheral blood mononuclear cells (pbmcs) in an amount of at least 4 million cells per milliliter and human chorionic gonadotropin (hcg in an amount of at least 150 international units (iu) per milliliter. A method of preparing the blood product, including applying hcg to a female patient, then obtaining pbmcs from the female patient, then adding hcg to the obtained pbmcs.
Progena Inc.

Treating vascular disease and complications thereof

Administration of an antibody that specifically binds il-1α is useful for reducing the chance or severity of a major adverse clinical event occurring in a mammalian subject having received or expected to receive surgical treatment for a stenosed blood vessel, and for reducing the change of restenosis occurring (or increasing the time until restenosis occurs) in a mammalian subject having received or expected to receive surgical treatment for a stenosed blood vessel.. .
Xbiotech, Inc.

Fibroblast growth factor (fgf) 1 mutants and methods of use to reduce blood glucose

The present disclosure provides fgf1 mutant proteins, which include an n-terminal deletion, point mutation(s), or combinations thereof. In some examples, the mutant fgf1 proteins have reduced mitogenic activity.
Salk Institute For Biological Studies

Saxatilin-fc fusion protein and use thereof

The present invention relates to a saxatilin derivative having an increased half life and a use thereof. The saxatilin derivative of the present invention has thrombolytic ability similar to that of saxatilin, which is the mother protein, a remarkably increased protein half life, and efficiently dissolves, for long period of time, blood clots already formed in blood vessels of an animal model with a fecl3-induced carotid by using the same.
Industry-academic Cooperation Foundation, Yonsei University

Apparatus and methods for treating hardened vascular lesions

An angioplasty catheter comprises a catheter body having a balloon or other radially expandable shell at its distal end. A non-axial external structure is carried over the shell and scores a stenosed region in a blood vessel when the balloon is inflated therein.
Angioscore, Inc.

Bioengineered allogeneic blood vessel

The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells.
Novahep Ab

Endonuclease targeting blood coagulation factor viii gene and composition for treating hemophilia comprising same

The present invention provides a method for inducing an inversion of normal blood coagulation factor viii (f8) gene, a method for correcting an inversion of blood coagulation factor viii gene in which the inversion has occurred, and a hemophilia a patient-derived induced pluripotent stem cell in which the inversion is corrected, constructed using the same. The method of the present invention effectively reproduces the inversion of intron 1 and intron 22 of the f8 gene, which is responsible for the majority of severe hemophilia a, and thereby may be effectively used for studying the development mechanism of hemophilia a and as a research tool for screening therapeutic agents.
Institute For Basic Science

Traditional chinese medicine composition for preventing and treating externally diabetes and a using the same

The invention discloses a traditional chinese medicine composition and a method thereof for preventing and treating externally diabetes, which is characterized in that the traditional chinese medicine composition is composed of astragalus membranaceus, salvia miltiorrhiza, stigma maydis, cortex lycii radicis, wolfberry, prunella vulgaris, mulberry leaf, cornus officinalis, lycopodium clavatum, the root of bidentate achyranthes, rhizoma chuanxiong, chinese atractylodes, yam, puerarin, fructus arctii, cassia twig; the method of use is to put a 40-50 g/ml medicine bags of the chinese herbal medicine powder or decoction into a foot pot, brew with boiling water, and then steam more than 10 minutes with the traditional chinese medicine steam after stirring evenly. When the water is cooled to 40-42° c., soaking feet once a day before going to bed, a course for foot soaking being 20 days; the contents of blood glucose and symptom of polydipsia, polyuria and polyphagia of the patients can be effectively reduced and disappeared by the foot bath in traditional chinese medicine, thus improving the immunity of the body and activating the autoimmunity as well as promoting the self-healing ability for the disease; and also such diseases as diabetic peripheral neuropathy (dpn), diabetic foot, diabetic nephropathy (dn), uremia caused by renal insufficiency resulted from diabetes can be prevented..

Composition for preventing or treating inflammatory diseases, comprising lactic acid bacteria-derived extracellular vesicles as active ingredients

Provided is a composition for preventing, ameliorating, or treating inflammatory diseases, the composition including, as active ingredients, lactic acid bacteria-derived extracellular vesicles isolated from culture fluid of lactic acid bacteria; and a method for diagnosing atopic dermatitis. The composition including the lactic acid bacteria-derived extracellular vesicles as active ingredients is expected to be usefully used in development of drugs, cosmetics, or health functional food for preventing, ameliorating, or treating inflammatory diseases such as atopic dermatitis, chronic rhinitis, chronic rhinosinusitis, asthma, chronic obstructive pulmonary disease, sepsis, etc.
Md Healthcare Inc.

Rheological blood replacement solution and uses thereof

The present invention relates to a polymer solution for use as a rheological blood substitute. The rheological blood replacement solution comprises in its basic composition a water-soluble cellulose polymer with a molecular weight of 100 kda or greater, polyethylene oxide and a solvent.
Universitätsmedizin Der Johannes Gutenberg- Universtät Mainz

Great vessel graft suturing aid

A stabilization tool supports a blood vessel for suturing during cardiovascular surgery. The support vessel may typically be part of an artificial graft used in replacing an aortic arch.
Terumo Cardiovascular Systems Corporation

Axial lengthening thrombus capture system

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (pe), deep vein thrombosis (dvt), cerebrovascular embolism, and other vascular occlusions.. .
Kp Medcure, Inc.

Vena cava filter with dual retrieval

An intravascular filter assembly has an expanded state for capturing thrombi in a patient's blood vessel, a first a collapsed state for removal from the patient's blood vessel in a first direction and a second collapsed state for removal from the patient's blood vessel in a second direction. A plurality of first struts extends from a first axial side of a fixed hub, and a plurality of second struts extends from the opposite axial side of the fixed hub.
Cook Medical Technologies Llc

Vascular closure device

A vascular closure system is configured to seal an incision in a vessel of the patient's body. The system includes a slider that is moved from an initial position to a deployed position (that is, towards the puncture of the patient body), until the proximal end of the slider exposes a reference marker on an inner tube.
Meril Life Sciences Pvt. Ltd.

Medical imaging device and medical image processing method

A method of processing a medical image includes acquiring a three-dimensional (3d) medical image indicating a blood vessel and a two-dimensional (2d) medical image indicating the blood vessel, determining a blood vessel area in the 3d medical image corresponding to a partial area of the blood vessel in the 2d medical image, and matching the blood vessel area with the partial area in the 2d medical image.. .
Seoul National University R&db Foundation

System and health monitoring including a user device and biosensor

A biosensor unit is coupled to a user device and may communicate with the user device over a short range wireless or wired interface. The biosensor unit includes an optical sensor used to obtain an oxygen saturation level, a heart rate and a respiration rate of a user.
Sanmina Corporation

Blood glucose monitoring device

A blood glucose monitoring device includes a container, blood glucose test strips and a glucometer. The container includes a body and a cap.

Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes at least one light source configured to strike a target area of a sample, at least one light detector, which includes a preamplifier having a feedback resistor, positioned to receive light from the at least one light source and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, and a processor configured to receive the output signal from the at least one light detector and based on the received output signal, calculate the attenuance attributable to blood in a sample present in the target area and eliminate effect of uncertainty caused by temperature dependent detector response of the at least one light detector, and based on the calculated attenuance, determine a blood glucose level associated with a sample..
St. Louis Medical Devices, Inc.

Body-worn system for measuring continuous non-invasive blood pressure (cnibp)

The present invention provides a technique for continuous measurement of blood pressure based on pulse transit time and which does not require any external calibration. This technique, referred to herein as the ‘composite method’, is carried out with a body-worn monitor that measures blood pressure and other vital signs, and wirelessly transmits them to a remote monitor.
Sotera Wireless, Inc.

Blood pressure estimation apparatus, blood pressure estimation method, and non-transitory computer-readable recording medium

A blood pressure estimation apparatus includes: a pulse wave measurement unit measuring a user's pulse wave signal; an electrocardiogram signal measurement unit measuring a user's electrocardiogram signal; and a processing circuit estimating a user's blood pressure value by using the pulse wave and electrocardiogram signals, wherein the processing circuit (a) acquires a pulse wave signal feature by using the pulse wave signal, (b) acquires an electrocardiogram signal feature by using the electrocardiogram signal, (c) acquires a pulse wave propagation time by using the pulse wave and electrocardiogram signals, (d) selects a blood pressure group indicating a relationship between a pulse wave propagation time and blood pressure of the user by using the pulse wave signal feature, electrocardiogram signal feature, and pulse wave propagation time, and (e) estimates the blood pressure value by using the blood pressure group, pulse wave signal feature, electrocardiogram signal feature, and pulse wave propagation time.. .
Panasonic Intellectual Property Management Co., Ltd.

Patient monitor for determining microcirculation state

As placement of a physiological monitoring sensor is typically at a sensor site located at an extremity of the body, the state of microcirculation, such as whether vessels are blocked or open, can have a significant effect on the readings at the sensor site. It is therefore desirable to provide a patient monitor and/or physiological monitoring sensor capable of distinguishing the microcirculation state of blood vessels.
Masimo Corporation

Method and device for computing optical hemodynamic blood pressure

Device for measuring blood pressure hemodynamically in blood vessels at one or more body locations comprising light source; at least three sensors including an array of at least three optical sensors, for receiving light and for obtaining a signal over time comprising temporal per pixel information for at least two wavelengths of light, and corresponding to a flow of blood within a blood vessel over time; a processing unit configured to receive the signal and generate a continuous dynamic blood pressure reading by using the temporal per pixel information for the at least two wavelengths of light to produce heart rate signals from the blood flow, and by applying a modified windkessel model on the signal such that the blood pressure also depends on a spatial temporal pressure resistance function over time that depends on a body location of the blood flow over time, the pressure resistance function representing elastance/stiffness.. .
Cnoga Medical Ltd.

Image processing apparatus and endoscope apparatus

An image processing apparatus including: an image acquisition device for observing a living body; a blood vessel recognition device that irradiates the living body with an exploration laser beam and that recognizes a blood vessel; an arithmetic operation unit that calculates a first laser spot position on a first frame acquired by the image acquisition device when the blood vessel is recognized and that adds a mark corresponding to the first laser spot to a position on a second frame corresponding to the first frame, the second frame being acquired at a time different from the time of the first frame; and a display unit for displaying, on an image acquired by the image acquisition device, a plurality of the marks added by the arithmetic operation unit as a result of the blood vessel being recognized at a plurality of different times.. .
Olympus Corporation

Photoacoustic apparatus

A photoacoustic apparatus is used that has: a detecting unit that detects photoacoustic waves generated by an object containing contrast agent in first blood vessels of circulating blood and in second blood vessels; and a signal processing unit that generates contrast agent distribution and acquires contrast agent concentration change in the circulating blood. The signal processing unit acquires the position of the first blood vessels on the basis of a time-series change of the contrast agent distribution and the contrast agent concentration change, and lowers the concentration at the position of the first blood vessels on the basis of the contrast agent distribution..
Canon Kabushiki Kaisha

Contactless measuring and continuously monitoring arterial blood pressure

A contactless system for measuring and continuously monitoring arterial blood pressure includes a light source configured to illuminate light having at least one predetermined wavelength at a predetermined area of a human subject having an artery therein. A detector responsive to reflected light from the predetermined area is configured to continuously acquire images of the artery in the predetermined area.
Vivonics, Inc.

Systems and methods for angiography and motion corrected averaging

Optical coherence tomography (oct) may be used to acquire cross-sectional or volumetric images of any specimen, including biological specimens such as the retina. Additional processing of the oct data may be performed to generate images of features of interest.

Categorization data manipulation using a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer

Methods, systems, apparatuses, and/or computer programs. Mass spectrometer test data (e.g.

Sample for use in electrical characteristic measurement, electrical characteristic measurement method, and electrical characteristic measurement device

A sample for use in electrical characteristic measurement is provided including erythrocytes incompletely fixed with a fixative, the fixed erythrocytes being such that an electrical characteristic of a mixture of the fixed erythrocytes and plasma components can change over time. An electrical characteristic measurement method is provided including measuring an electrical characteristic of the sample for use in electrical characteristic measurement over time before measuring an electrical characteristic of blood samples over time.

Circulating tumor cell diagnostics for biomarkers predictive of resistance to androgen receptor (ar) targeted therapies

The disclosure provides a method of predicting resistance to androgen receptor (ar) targeted therapy in a prostate cancer patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to identify circulating tumor cells (ctcs), and (b) based on said direct analysis further determining the presence of a biomarker signature that is predictive of resistance to ar targeted therapy in the prostate cancer patient, wherein the biomarker signature comprises ck+, ar+, nucleoli+ctcs in a subpopulation of said ctcs. The present disclosure also provides a method of predicting resistance to taxane-based chemotherapy in a prostate cancer patient comprising (a) performing a direct analysis comprising immunofluorescent staining and morphological characterization of nucleated cells in a blood sample obtained from the patient to identify circulating tumor cells (ctcs), and (b) based on said direct analysis further determining the presence of a biomarker signature that is predictive of resistance to taxane-based chemotherapy in the prostate cancer patient, wherein the biomarker signature comprises ck+, ar−, nucleoli+, small size in a subpopulation of said ctcs..
Epic Sciences, Inc.

Method to detect the onset and to monitor the recurrence of chronic graft versus host disease in tranplantation patients

The described invention comprises a method for detecting the onset or monitoring the recurrence of chronic graft versus host disease (cgvhd) in a transplantation patient. The method comprises isolating peripheral blood mononuclear cells (pbmcs) from the transplantation patient and analyzing the isolated pbmcs to detect a biomarker specific for a donor cell.
The Board Of Trustees Of The Leland Stanford Junior University

Method and kit for examining complement system

A method for examining a complement system of a subject, including: a reaction step of letting a scavenger receptor or a functional equivalent thereof, a pentraxin family protein or a functional equivalent thereof and a blood sample collected from the subject coexist in vitro; and a detection step of detecting complement activation amplifying reaction and/or complement activation late-phase reaction induced by interaction between the scavenger receptor or the functional equivalent thereof and the pentraxin family protein or the functional equivalent thereof from a reactant after the reaction step. Also provided are a kit for examining a complement system, and a method for testing a test substance for the ability to activate or suppress a complement system..
National University Corporation Asahikawa Medical University

Optical measurement counting and/or differentiating leucocytes

Optical device (200) for blood analysis is in particular designed for the counting and differentiation of leucocytes in an automatic blood analysis apparatus and includes a light source (201) of the electroluminescent diode type in order to illuminate a blood sample (311) circulating in an optical tank.. .
C2 Diagnostics

Methods and uses for diagnosis and treatment of prostate cancer

In an aspect, the invention provides methods and uses of pcat18 for diagnosing, prognosing, and treatment monitoring of prostate cancer (pca) in a subject. In another aspect, methods of treating pca in a subject by administering an inhibiting agent of pcat18 are provided.
British Columbia Cancer Agency Branch

Sustainable laundry sour compositions with iron control

Linen treatment compositions and linen processes are disclosed which help to prevent iron deposition from wash water, and/or redeposition after iron containing stain (such as blood) removal by alkaline detergents. The linen treatment composition is a combination of a hydroxycarboxylic acid and an acid source, which may be organic or inorganic.
Ecolab Usa Inc

Modified von willebrand factor having improved half-life

The invention relates to a modified vwf molecule for use in the treatment of a blood coagulation disorder.. .
Csl Behring Recombinant Facility Ag

Portal system-based bionic pancreas

Embodiments include methods and systems for maintaining glucose homeostasis. Systems can include a pump, a first reservoir including a homeostasis agent, an umbilical catheter capable of being advanced in the umbilical vein or in the falciform ligament, and a sensor.
International Business Machines Corporation

Intestinal microbe therapy, composition therefor and preparing the same

The present invention discloses a method for treating and/or preventing metabolic syndrome and related diseases thereof, by administering a microbe composition to an individual to achieve the modulation of blood glucose, inhibition of body weight gain, reduction of low density cholesterol in blood, and reduction of hepatic expression of inflammatory factors, thereby effectively treating and/or preventing metabolic syndrome or related diseases thereof.. .
Taichung Veterans General Hospital

Implant insertion system

The invention concerns a device for introducing an implant (1) into blood vessels or hollow organs of the human or animal body, comprising an implant (1), an insertion wire (14) and a release tube (13), wherein the implant (1) is deformable so that it adopts a shape with reduced diameter in a microcatheter (8) and at the site of the implantation it expands once the external constraint of the microcatheter (8) disappears, adapting to the diameter of the blood vessel or hollow organ, wherein a holding element (2) is arranged on the insertion wire (14) and the holding element (2) has at its periphery at least one, preferably a plurality of grooves (3) set into the holding element (2), running along the circumference of the holding element (2) and forming tracks in the form of curved lines, wherein the implant (1) has at the proximal end at least one, preferably a plurality of holding wires (5) extending in the proximal direction, which are fitted into the grooves (3), wherein the release tube (13) is pulled with a form fit over the holding element (2) and the holding wires (5) fitted into the grooves (3), so that the holding wires (5) are held in the grooves (3) by frictional locking and a releasing of the implant (1) occurs by pulling back the release tube (13) in the proximal direction. According to an alternative embodiment, the invention concerns a device for introducing an implant (1), wherein the release tube (13) protrudes into the proximal end of the implant (1), wherein an elastic contact surface is present between the inside of the implant (1) and the outside of the release tube (13), so that a frictional locking is generated between implant (1) and release tube (13), bringing about a lengthwise mobility of the implant (1) inside the microcatheter (8) by lengthwise movement of the release tube (13) distally or proximally..
Phenox Gmbh

Preventing non-target embolization

Devices, methods and kits for preventing or reducing non-target microparticles deposition and embolization, in conjunction with delivering microparticles (e.g., embolization material) via a blood vessel to a target bodily part. Applicable for entrapping infiltrated microparticles within heart right atrium.
Accurate Medical Therapeutics Ltd.

Intravascular flow diversion devices

Described herein are devices and methods for closing abnormal communications between one or more vessels or a vessel and an organ. The devices and methods described herein are configured to divert a flow of a body fluid such as, for example, blood or bile away from the abnormal conduit thereby promoting thrombosis and occlusion in the case of blood vessel to blood vessel communication or an aneurysm and/or decrease in size of and epithelization of the communication such as in the case of a fistula..
Spartan Micro, Inc.

Multi-mode inflatable limb occlusion devices and methods

Methods for adaptive cuff inflation for the purposes of occluding a limb of a subject include inflating a cuff to a pressure at or above limb occlusion pressure and periodically deflating the cuff to detect amplitude of oscillometric oscillations reaching or exceeding a predetermined threshold, whereby indicating that the cuff pressure has reached an updated systolic blood pressure. Selecting the cuff to be wide enough to define limb occlusion pressure at or below the systolic blood pressure assures that this maneuver does not compromise cessation of blood flow to the limb.
Lifecuff Technologies Inc.

Catheters with side openings for modifying and delivering suspensions to a subject

Microcatheters and methods for modifying and delivering suspended particles to target bodily parts (e.g., of the cardiovascular system). Embolization microcatheters and uses thereof in performing local embolization procedures, involving modifying flow characteristics (momentum) of suspensions during delivery.
Accurate Medical Therapeutics Ltd.

3d ultrasound image stitching

A computer-implemented method for combining two 3-dimensional ultrasound images of a patient's body part containing blood vessels into a single 3-dimensional ultrasound image of that body part with a greater field of view. Blood vessels within the body part are used for registration.
The University Of Western Ontario

Sleep tracking systems, methods, and devices

Provided are mechanisms and processes for tracking sleep. Devices may include an accelerometer configured to measure macro and micro sensitivity movement of head, movement of throb of vessels close to the ear, monitor changes in heart rate and pulse rate and blood pressure.

Biological fluid separation device and biological fluid separation and testing system

A biological fluid separation device that is adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid separation device is able to separate a plasma portion from a cellular portion.
Becton, Dickinson And Company

Biological fluid separation device and biological fluid separation and testing system

A biological fluid separation device that is adapted to receive a multi-component blood sample is disclosed. After collecting the blood sample, the biological fluid separation device is able to separate a plasma portion from a cellular portion.
Becton, Dickinson And Company

Enhanced lancing device with suction

A lancet device is formed of an outer housing that provides a source of vacuum. An inside, nested lancet device may provide lancet blade cocking, locking, and release functions.

System and identifying blood pressure zones during autoregulation monitoring

A monitor configured to monitor autoregulation includes a memory encoding one or more processor-executable routines and a processor configured to access and execute the one or more routines encoded by the memory. When executed, the routines cause the processor to receive one or more physiological signals from a patient, determine a measure indicative of an autoregulation status of the patient based on the one or more physiological signals, generate an autoregulation alarm indicative of an impaired autoregulation status when the measure exceeds a predetermined threshold for more than a predetermined period of time..
Covidien Lp

Molecular characterization of circulating tumor cells

The disclosed invention includes methods and kits for the removal of white blood cells from samples of immunomagnetically enriched rare cells by treating the sample with a leukocyte marker conjugated to a hapten which adheres to the white blood cells and treating the resulting product with a second medium that adheres to the hapten of the white blood cells that are labeled with the leukocyte marker conjugated to hapten and removing the labeled white blood cells.. .
Menarini Silicon Biosystems, Inc.

Method for evaluating coagulation ability of blood specimen, and reagent, reagent kit and device to be used therein

The present invention relates to a method for evaluating coagulability of a blood specimen obtained from a subject to whom a substance having a coagulation factor viii-substituting activity is administered. The present invention also relates to a reagent for blood coagulation analysis, a reagent kit for blood coagulation analysis, and an apparatus for blood coagulation analysis.
Sysmex Corporation

Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles.
Angle North America, Inc.

Biosensor system, sensor chip, and measuring analyte concentration in blood sample

The present invention provides a biosensor system that can prevent a measurement error caused by the temperature of the environment in use from occurring. A biosensor system 100 includes a measuring instrument 101 having an operation part 306, and a sensor chip 200 that is insertable into and removable from the measuring instrument 101 and into which a blood sample is introduced.
Panasonic Healthcare Holdings Co., Ltd.

Method for production of heparin and heparan sulfate

This present disclosure relates to a method of producing a proteoglycan having anticoagulant activity, comprising of and providing a cell transfected with a recombinant nucleic acid encoding a core protein having one or more glycosaminoglycan attachment sites; and incubating the cell under conditions to promote the production of a proteoglycan comprising the core protein linked to heparin and/or hs and optionally other glycosaminoglycan chains, and to heparin or heparan sulphate isolated from such proteoglycans that have significant anti-coagulant activity. The invention also relates to a recombinant proteoglycan comprising a core protein and heparin and/or heparan sulfate, to a cell capable of producing a proteoglycan comprising the core protein and heparin and/or heparan sulfate, and to a method of treating or preventing blood coagulation, or a condition associated with blood coagulation, using the recombinant proteoglycan comprising a core protein and heparin and/or heparan sulfate and/or the heparin and/or heparan sulfate isolated from such proteoglycans..
Newsouth Innovations Pty Limited

Substituted bridged urea analogs as sirtuin modulators

Provided herein are novel substituted bridged urea and related analogs and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
Glaxosmithkline Llc

Assembly with a guide wire and a fixator for attaching to a blood vessel

A fixator assembly comprising a fixator for fixing inside a blood vessel, the fixator being able to slide proximally along a guide wire. The assembly comprising means for preventing the fixator from moving distally of the preventing means.
Endovascular Development Ab

Method and system for closed-loop control of an artificial pancreas

Methods and systems for controlling an insulin pump in response to glucose measurements are responsive to a base insulin delivery profile and a temporary insulin delivery profile. These can be used, e.g., to control blood glucose level of a subject using a continuous glucose monitor and an insulin infusion pump.
Animas Corporation

Femoral arterial cannula capable of guiding bidirectional perfusion flow

The present invention relates to a cannula for femoral arterial bidirectional (a heart direction and a distal lower extremity direction) perfusion. The cannula, which has a cannula tube to be inserted into a blood vessel of the femoral artery, includes a perfusion guide channel formed as a concave part from a predetermined portion of an inner circumferential surface at an end of the cannula tube to the opposite end thereof in a length direction and further includes a through-hole provided at a boundary portion between the perfusion guide channel and the cannula tube in an end direction of the cannula tube, or includes a through-hole provided in a predetermined portion of to an inner circumferential surface of an end of the cannula tube and a guide cover provided at an upper portion of the through-hole to cover the upper portion of the through-hole and guide perfusion.
Samsung Life Public Welfare Foundation

Magnetic filtration devices and methods related thereto

In vivo and ex vivo positionable magnetic filtration devices are provided that magnetically filter one or more therapeutic agents conjugated to a magnetic particle in blood flowing in a blood vessel.. .
The Regents Of The University Of California

Adaptive peritoneal dialysis intra-session adjustments for overall session optimization

The invention relates to systems and methods for adjusting one or more dialysis parameters for delivering a peritoneal dialysis cycle to a patient based on patient or system parameters. The systems and methods include various sensors, flow paths, and processors to adjust the dialysis parameters used to deliver peritoneal dialysis therapy, for a specific peritoneal dialysis cycle.
Medtronic, Inc.

Compounds for improving the half-life of von willebrand factor

The invention relates to a compound, preferably an antibody, capable of binding to the receptor protein clec10a for use in the treatment of a blood coagulation disorder.. .
Csl Behring Recombinant Facility Ag





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