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Blood patents

      

This page is updated frequently with new Blood-related patent applications.

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 Method for non-invasive prenatal testing using parental mosaicism data patent thumbnailnew patent Method for non-invasive prenatal testing using parental mosaicism data
Provided herein are methods for determining the ploidy state of one or more chromosome in a developing fetus. The subject methods provide for increase accuracy by utilizing information about the mosaicism level of one or more chromosomes of interest in the mother of fetus.
Natera, Inc.


 Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129xe mri patent thumbnailnew patent Systems and methods for assessing pulmonary gas transfer using hyperpolarized 129xe mri
Methods and systems for assessing pulmonary gas exchange and/or alveolar-capillary barrier status include obtaining at least one mri image and/or image data of 129xe dissolved in the red blood cells (rbc) in the gas exchange regions of the lungs of a patient. The image is sufficiently sensitive to allow a clinician or image recognition program to assess at least one of pulmonary gas exchange, barrier thickness or barrier function based on the 129xe mri rbc image..
Duke University


 Method patent thumbnailnew patent Method
A method is provided, comprising feeding a cat a foodstuff comprising a protein to fat ratio of 1:0.27 to 1:0.63 on a gram:gram as fed or dry matter basis, and measuring the level of glucose-dependent insulinotropic polypeptide (gip) in a blood sample from the cat before and after feeding the foodstuff. A reduction in gip levels and/or maintaining low levels of gip post-prandially is indicative of a foodstuff useful in preventing accumulation of and/or reducing body fat in a cat and therefore controlling the body weight of a cat..
Mars, Incorporated


 Glycated protein assay patent thumbnailnew patent Glycated protein assay
Methods, devices, and reagents are described for performing assays for hemoglobin ale, glycated albumin, and other glycated proteins. The methods involve a ratio determination between glycated protein and non-gtycated protein.
Bio-rad Laboratories, Inc.


 Markers and therapeutic indicators for glioblastoma multiforme (gbm) patent thumbnailnew patent Markers and therapeutic indicators for glioblastoma multiforme (gbm)
A signature of proteins occurring in glioblastoma multiforme (gbm) tissue comprised of 33 cell surface proteins (gbmsig) that distinguish subjects with gbm from healthy controls with more than 98% accuracy is described. In addition, four of the members of this signature are particularly useful as blood-borne markers of gbm.
Institute For Systems Biology


 Systems and methods for a versatile electrochemical test strip that may include one or more assays for different analytes in the same test strip patent thumbnailnew patent Systems and methods for a versatile electrochemical test strip that may include one or more assays for different analytes in the same test strip
A test strip for electrochemical testing of a blood analyte includes a plurality of test sites for the electrochemical testing of analytes on a single test strip. Each test site includes a first receiving port, the first receiving port for receiving a blood sample, the first receiving port at a first end of the test strip.
Polymer Technology Systems, Inc.


 Biochemical analysis of pbmc patent thumbnailnew patent Biochemical analysis of pbmc
A method is provided comprising, obtaining an infrared (ir) spectrum of a peripheral blood mononuclear cells (pbmc) sample by analyzing the sample by infrared spectroscopy; and based on the infrared spectrum, generating an output indicative of the presence of a solid tumor or a pre-malignant condition. Other embodiments are also provided..
Todos Medical Ltd.


 Blood collector with capillary structure patent thumbnailnew patent Blood collector with capillary structure
System and method of determining an amount of an analyte in a blood sample using a cartridge and blood collector are disclosed. The blood collector has a mounting surface, a capillary structure with a curved portion, and a capillary inlet.
Roche Diagnostics Operations, Inc.


 Methods for assessing liver pathologies patent thumbnailnew patent Methods for assessing liver pathologies
The present invention provides a new method for detecting or monitoring a liver disease in a subject that has no indication of any liver pathologies, by measuring the amount of concentration of albumin mrna in an acellular blood sample from the subject, and then comparing the amount or concentration of albumin mrna with a standard control.. .
The Chinese University Of Hong Kong


 Rapid, low-sample-volume cholesterol and triglyceride assays patent thumbnailnew patent Rapid, low-sample-volume cholesterol and triglyceride assays
Reagents, assays, methods, kits, devices, and systems for rapid measurement of cholesterol and cholesterol sub-fractions from a blood sample are provided. Total cholesterol, low density lipoprotein cholesterol, and high density lipoprotein cholesterol can be measured in a single assay using kinetic measurements, under conditions in which cholesterol sub-species are converted to a detectable product at distinct rates.
Theranos, Inc.


new patent

Method for detecting a plasmodium infection

The invention relates to a method for detecting a plasmodium infection in a patient blood sample, wherein a differential analysis of the polymorphonuclear neutrophil granulocytes in the sample is performed, and the distribution of the cell volume and the cell density, the number of thrombocytes in the sample, and the distribution of the cell density of the thrombocytes in the sample is determined.. .
Siemens Healthcare Diagnostics Products Gmbh

new patent

Methods and creating particle derivatives of hdl with reduced lipid content

The present invention is directed to systems, apparatus and methods for creating derivatives of at least one form of hdl without substantially affecting ldl. These derivatives of hdl are particles with reduced lipid content, particularly reduced cholesterol content.
Hdl Therapeutics

new patent

Tfpi inhibitors and methods of use

The invention provides peptides that bind tissue factor pathway inhibitor (tfpi), including tfpi-inhibitory peptides, and compositions thereof. Peptide complexes also are provided.
Baxalta Incorporated

new patent

Medical systems, devices and methods

There is disclosed a medical system comprising one or more sensors associated with one or more actuators. Various embodiments describe sensors and/or actuators, logic circuits, user interfaces, association schemes, communication schemes, security schemes, cryptographic schemes, medical management rules, social mechanisms, energy management schemes, time and/or space schemes, body analytes and/or biomarkers, blood glucose and/or interstitial glucose sensors, drug delivery devices, continuous glucose monitoring devices, as well as flash glucose monitoring devices.

new patent

Modular blood treatment systems, units, and methods

A portable adapter is provided that can include a closure system configured to control the flow of blood and/or dialysate between the adapter and a blood treatment apparatus. Modular systems are also provided that include the portable adapter engaged with various units such as a portable blood processing module, a non-portable base module, and/or a remote module.
Fresenius Medical Care Holdings, Inc.

new patent

Methods of sustaining dietary ketosis and its effects on lipid profile

The ketogenic diet (kd) has therapeutic implications in many disease states. It was hypothesized ketone precursor supplementation would elevate blood ketone levels to therapeutic ranges (2-7 mm) without need for dietary restriction.
University Of South Florida

new patent

Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same

Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles.
Celonova Biosciences Germany Gmbh

new patent

Medical containers and system components with non-dehp plasticizers for storing red blood cell products, plasma and platelets

A container for blood or a blood component is provided, the container comprising one or more container walls defining an interior chamber, the container walls comprising one or more layers, the layers comprising or consisting of a composition comprising one or more polymeric materials and at least one extractable agent selected from the group consisting of a terephthalate ester, a cyclohexane dicarboxylic acid ester, a citrate ester, and a polyol ester, wherein the container further comprises one or more additional components, wherein the container comprises less than about 3% (w/w) of di-2-ethylhexyl phthalate (dehp), preferably wherein the container comprises less than about 3% (w/w) of phthalates. Thereby, improved blood products are provided in which the dehp or overall phthalate content is reduced..
Fresenius Hemocare Netherlands B.v.

new patent

Intraluminal devices configured for directional expansion

Methods and devices useful, for example, in the field of angioplasty and stenting are disclosed. In some embodiments, the methods, devices and kits are configured for directional expansion inside a lumen, for example of a blood vessel obstructed by plaque.

new patent

Electrochemical protection of conducting circuit in the body of a patient

The preferred embodiment provides apparatus for ablating a vessel by generating heat within a vessel to cause blood clotting to occlude the vessel. The apparatus includes an electrically resistive element at the distal end of the apparatus, the resistive element being uncoated and therefore in bare form.
Cook Medical Technologies Llc

new patent

Direct stream hydrodynamic catheter system

A direct stream hydrodynamic catheter system is provided for the removal of thrombus, lesions and the like including provisions for the infusion of drugs, lysing fluids and the like into a blood vessel. Physician controlled powered direct fluid jet streams emanate from a fluid jet emanatory in the form of robust radially directed fluid jet streams to impinge upon and ablate difficult and strong thrombus and lesions within a blood vessel.
Boston Scientific Limited

new patent

Aneursym occlusion system and method

An aneurysm occlusion system includes a device positionable within a cerebral blood vessel covering a neck of an aneurysm on the blood vessel. The device includes an expandable tubular element having a lumen surrounded by a sidewall including a plurality of gaps.
Penumbra, Inc.

new patent

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

new patent

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

new patent

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

new patent

Multi-functional smart mobility aid devices and methods of use

Embodiments of a smart mobility aid device may have sensors to collect, monitor, analyze and represent data including but not limited to activity tracking, biometrics and safety and emergency features. The activity tracking include number of steps, miles, and activity speed, user pressure on a device, activity types and analysis.

new patent

Method and apparatus of calculating blood pressure

Provided is a method and apparatus to measure pulse wave information of a user. The method and apparatus obtain a basic blood pressure of the user estimated based on body information of a user.
Samsung Electronics Co., Ltd.

new patent

Method for measuring cardiovascular and respiratory parameters based on multi-wavelength photoplethysmography

Accurate and effective methods for measuring cardiovascular and respiratory parameters are provided. The method for deriving a depth-specific photoplethysmography (ppg) signal from multi-wavelength ppg signals includes choosing light wavelength combinations, calibrating a multi-layer light-tissue interaction model referring to a physiological signal, and generating the depth-specific ppg signal from the multi-wavelength ppg signals based on the calibrated light-tissue interaction model.
The Chinese University Of Hong Kong

new patent

Blood pressure estimation device, blood pressure estimation method, blood pressure measurement device, and recording medium

Disclosed are a blood pressure estimation device and the like which make it possible to estimate blood pressure with a high degree of accuracy. A blood pressure estimation device (101) has: a pulse wave calculation unit (102) for, on the basis of a pressure signal in a specific period and a pulse wave signal (2001) measured on the basis of the pressure of the pressure signal in the specific period, calculating a plurality of times at which a pulse signal satisfies prescribed conditions, a period representing the difference between the times, and a pressure value of the pressure signal during the period, and also calculating pulse wave information associating the period and the pressure value; and a blood pressure estimation unit (103) for estimating the blood pressure of the pulse wave signal (2001) on the basis of the pulse wave information..
Nec Corporation

new patent

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

new patent

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

new patent

Wearable apparatus, detection of cardiac arrest and alerting emergency response

The disclosure provides wearable cardiac arrest detection and alerting device that incorporates a non-invasive sensor based on optical and/or electrical signals transmitted into and received from human tissue containing blood vessels, and that transcutaneously quantifies the wearer's heart rate. The heart-rate quantification enables the detection of the absence of any heart beat by the wearable detection and alerting device indicative of the occurrence of a cardiac arrest, wherein the heart is no longer achieving effective blood circulation in the individual wearing the device.
Eggers & Associates, Inc.

new patent

Neck-worn physiological monitor

The invention provides a neck-worn sensor that is a single, body-worn system that measures the following parameters from an ambulatory patient: heart rate, pulse rate, pulse oximetry, respiratory rate, temperature, thoracic fluid levels, stroke volume, cardiac output, and a parameter sensitive to blood pressure called pulse transit time. From stroke volume, a first algorithm employing a linear model can estimate the patient's pulse pressure.
Tosense, Inc.

new patent

Medical-image processing apparatus, controlling the same, and storage medium

An information processing apparatus includes an acquisition unit, a specification unit, a determination unit, a generation unit, and a display control unit. The acquisition unit acquires a three-dimensional image containing at least a tubular structure.
Canon Kabushiki Kaisha

Kinesthetic sensors for determining angular displacements

A kinesthetic sensor measure angular displacement of body parts of users by measuring a density of substances contained in a conduit of the kinesthetic sensor. For example, the kinesthetic sensor measures the density of substance including in a conduit by transmitting a signal into the conduit and measuring the signal after the signal passes through the conduit and one or more substances included in the conduit.
Oculus Vr, Llc

Crossmatching blood samples

The present invention provides novel methods for the detection of antibodies, in particular, blood group antibodies. The methods of this invention may be applied to pre-transfusion blood compatibility testing for the detection of incompatibility between donor units (comprising donor red blood cells (erythrocytes)) and a recipient..
Qbd (qs-ip) Limited

Smartphone compatible on-chip biodetection using integrated optical component and microfluidic channel with nanopillar array

Methods, apparatuses, and computer program products are provided where fluid, such as a blood sample, is entered into a microfluidic channel in a microchip where the microfluidic channel possesses a micro/nanopillar array for sorting molecules by size. When the fluid passes through the micro/nanopillar array it is separated into particles of interest or particles not of interest or both.
International Business Machines Corporation

Method and system for rapid malaria detection

The invention described herein relates to a method of detecting malaria comprising the steps of: (i) delivering an evanescent ir beam through said atr substrate in contact with a patient blood sample; (ii) detecting ir radiation transmitted from the atr substrate to produce a signal characteristic for one or more lipids in the sample, and (iii) processing said signal and a set of reference library spectra of lipids associated with malaria parasites in order to detect matches and quantify said one or more lipids in the sample. In contrast to the prior art, the present invention relies on detecting lipids instead of hemozoin..
University Of Melbourne

Method for predicting congenital heart defect

Particular aspects of the invention confirm significant differences in methylation of cytosine bases in many loci throughout the genome in cases of congenital heart defect (chd) compared to normal cases without chd. Additional aspects provide novel methods for the prediction of congenital heart defects that can be applied to embryos, fetuses, newborns and different stages of postnatal life including childhood and any time in later postnatal life, is disclosed.
Bioscreening And Diagnostics Llc

Cancer-targeted il-12 immunotherapy

The invention is directed to cancer immunotherapy. The invention is specifically directed to the induction of innate or adaptive antitumor immunity initiated by the administration of targeted il-12 molecules preferably in conjunction with il-2 and/or il-7 to a cancer patient, who suffers from cancer of the muscle, bone, nerves, cartilage, tendons, blood vessels, etc., preferably from sarcoma.
Merck Patent Gmbh

Peptides for promoting angiogenesis and use thereof

The present invention relates to a peptide promoting angiogenesis and novel use thereof. More particularly, the invention relates to peptides promoting angiogenesis, and the use of the peptide for promoting angiogenesis and preventing or treating angiogenesis-related disease.
Samsung Life Public Welfare Foundation

Particle suction capture mechanism and unstopping device equipped with particle suction capture mechanism

A device for unstopping a stopped specimen vessel that contains a liquid specimen such as blood is equipped with a mechanism which sucks and captures particles floating around the opening of the specimen vessel and prevents contamination of the specimen. The unstopping device grips a vessel and the stopper of the opening of the vessel, and removes the stopper from the opening of the vessel by changing the relative distance between the vessel-gripping mechanism and the unstopping mechanism.
Hitachi High-technologies Corporation

Apparatus for the separation of plasma

The invention relates to an apparatus for separating blood and at the same time an apparatus (1) for absorbing blood (19) and separating components such as blood plasma, as a sample liquid (2), having a feed device (13) for receiving the blood (2), a separating device (15) for separating blood components as the sample liquid (2), a channel (3) which takes up the sample liquid (2) preferably exclusively by capillary forces and a fill device for filling the channel (3) with sample liquid (2) in an inlet or feed region (18) of the channel (3), wherein the separating device (15), particularly a membrane, is domed, more particularly convexly shaped and projects with the apex of the convex shape into the filling device in the direction of filling.. .
Boehringer Ingelheim Microparts Gmbh

Gas removal systems and methods

An air removal device for an intravenous fluid system includes a housing with an inlet for fluid communication with a fluid source, a fluid outlet for fluid communication with a blood vessel of a patient, and an air outlet. The air removal device further includes a disrupting element disposed within the housing in a flow path between the inlet and the fluid outlet, and an air chamber in fluid communication with the air outlet.

Devices and methods for controlling blood perfusion pressure

Devices and methods for controlling blood perfusion pressure. In an exemplary device for controlling blood perfusion pressure within a vessel of the present disclosure, the device comprises an elongated body having a lumen, a proximal end configured for placement in a first area having a first blood pressure, and a distal end configured for placement in a second area having a second blood pressure, partial occluder positioned within the lumen of the elongated body between the proximal end and the distal end, the partial occluder configured so not to fully occlude a blood vessel, wherein the partial occluder is configured to equalize the first blood pressure at the first area with the second blood pressure at the second area..
Cvdevices, Llc

System and delivering protease inhibitors

The disclosed invention provides a system and method of artificially retarding fibrin-based blood clot degradation via the sustained release of a protease inhibitor, such as, for example, aprotinin or tranexamic acid (“ta”). The sustained release of the protease inhibitor is accomplished through incorporation within a biodegradable polymer microsphere to produce a protease inhibitor formulation.
Bordoloi Biotech, Llc

Methods of implanting a prosthesis

A method of implanting a prosthesis in a patient at a treatment site within a blood vessel includes advancing an outer catheter of a prosthesis delivery system in the patient distal to the treatment site, the outer catheter defining an inside diameter and advancing an inner sheath, having greater flexibility than the outer catheter and an outside diameter that is greater than the inside diameter of the outer catheter, and a guidewire lumen of the delivery system from the outer catheter to the treatment site along a guidewire while the outer catheter remains stationary relative to the patient, whereby advancing the inner sheath delivers the prosthesis to the treatment site. The inner sheath is retracted to deploy the prosthesis from within the inner sheath and at the treatment site after which the delivery system from the patient..
Bolton Medical, Inc.

Devices, systems, and methods for reshaping a heart valve annulus

Anchors for securing an implant within a body organ and/or reshaping a body organ are provided herein. Anchors are configured for deployment in a body lumen or vasculature of the patient that are curved or conformable to accommodate anatomy of the patient.
Mvrx, Inc.

Curette for pituitary adenoma surgery

A curette for pituitary adenoma surgery may include a curette having a tubular blade portion. A first cutting edge is formed at a first end of the blade portion, and a protective shell is formed at an outer periphery of the first cutting edge.
Department Of Electrical Engineering, National Changhua University Of Education

Embolectomy devices and methods for treatment of acute ischemic stroke condition

Clot engagement element comprising bundle of unwoven fibers can be assembled to form an acute stroke treatment device. The device has the capability of forming a three dimensional filtration matrix comprising effective pores with a distribution of sizes.
Mivi Neuroscience, Inc.

Image processor, ultrasound diagnostic device including same, and image processing method

An image processor including image processing circuitry including: a blood flow image obtainer that obtains a blood flow image in which a blood flow area is mapped, the blood flow area indicating blood flow in the examination subject; a tomographic image obtainer that obtains a tomographic image including an image of a body tissue inside the examination subject; a characteristic obtainer that obtains, based on the blood flow image and the tomographic image, a combination of a first characteristic being a characteristic of the blood flow area itself and a second characteristic indicating a relationship between the blood flow area and the image of a body tissue in the tomographic image; and a blood flow evaluator that evaluates a likelihood of the blood flow area indicating a new blood vessel, based on the combination of the first characteristic and the second characteristic of the blood flow area.. .
Konica Minolta, Inc.

Measuring respiration rate with multi-band plethysmography

A photoplethysmogram (ppg) signal may be obtained from a pulse oximeter, which employs a light emitter and a light sensor to measure the perfusion of blood to the skin of a user, and multiple wavelengths of light may be employed. For various wavelengths, relatively long wavelengths may interrogate relatively deep blood vessels in comparison to relatively short wavelengths, which may interrogate relatively shallow blood vessels.
Apple Inc.

Manual computer interface with integral glucose monitor system

A glucose monitor computer mouse for enabling blood sugar testing from a coupled computer and automatically storing results on the coupled computer. The glucose monitor computer mouse includes both a computer mouse assembly, defining a conventional computer pointing device, and an integrated blood glucose meter which provides blood sugar readings from disposable testing strips like conventional blood glucose meters.

Information obtaining apparatus, image capturing apparatus, and obtaining information

An information obtaining apparatus capable of obtaining information about a blood vessel with high accuracy includes a first unit configured to obtain three or more image data pieces different in imaging conditions, a second unit configured to obtain a first index value of a first region and a second index value of a second region, a third unit configured to select a pair of the image data pieces from the three or more image data pieces using the first index value and the second index value of the image data, and a fourth unit configured to obtain information about a blood vessel using the selected pair of the image data pieces.. .
Canon Kabushiki Kaisha

Blood pressure sensor

The disclosure relates to a system for monitoring at least one physiological parameter. The system comprises a measuring apparatus having a sensor unit for detecting the at least one physiological parameter and having a transmission device, and a reading apparatus for receiving data relating to the at least one physiological parameter.
Infineon Technologies Ag

Providing image support to a practitioner

A three-dimensional subtraction angiography image data set including a target region of the patient is acquired. A region of interest is selected.

Systems, methods, and biomarkers for determining the metabolic state of red blood cells and platelets

Disclosed herein are methods, biomarkers, systems, compositions and kits for determining the phase or metabolic state (e.g. First phase, second phase, or third phase) of a red blood cell (rbc) sample or for determining the phase or metabolic state (e.g., first phase or second phase) of a platelet (plt) cell sample.
University Of Iceland, Center For Systems Biology

Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles.
Angle North America, Inc.

Determining viability for resuscitation

Portable automated systems and methods can be used to perform field testing of patient blood chemistry to determine whether biological death has occurred in a clinically dead patient, and therefore whether the patient is a viable candidate for resuscitation efforts. A blood sample is received in a detector, which analyzes the blood sample to generate a signal representing at least one blood chemistry parameter of the blood sample and transmits a signal representing the at least one blood chemistry parameter to a processor.

Determining conditions in centrifuged blood using measured pressure

A method for determining a condition in a blood sample includes: providing a sample of blood; providing a metering probe having a pump for aspirating and dispensing; inserting the metering probe a selected distance into the blood sample; measuring the pressure between the sample and pump during sample aspiration or sample dispense; comparing the measured pressure with a reference value; and signaling the presence or absence of the condition. A method for confirming or detecting the presence of a selected layer of blood component in a centrifuged blood sample includes: measuring a pressure of a suspected selected layer in a metering probe during aspiration or dispense; comparing the measured pressure with a reference value, wherein if the measured pressure and the reference value are substantially identical then the selected layer of the blood component is confirmed.
Ortho-clinical Diagnostics, Inc.

Methods for segregating particles using an apparatus with a size-discriminating separation element having an elongate leading edge

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles.
Angle North America, Inc.

Cancer cell growth inhibition and killing device using blue light led

Provided is a cancer cell growth inhibition and killing device using a blue light led. The present invention comprises: a bed part which has a top plate on which the body is laid to stand by; a main body part provided with a treatment space, which has a predetermined size and on which the bed part is disposed, and having a chamber which is divided by the treatment space and a transparent plate formed of a light-transmitting material to thus form a treatment light generation space; and a treatment light generation unit which generates a treatment light having a wavelength band of a predetermined size when power is applied so that the treatment light can penetrate the subcutaneous tissue of the body and thereby stimulate and kill cancer cells moving along blood vessels, and which is provided in the chamber so as to irradiate the treatment space with the treatment light after the treatment light has penetrated though the transparent plate..
Industrial Cooperation Foundation Chonbuk National University

Catheter guidance through a calcified aortic valve

A method of treating a patient with a calcified aortic valve includes introducing a guide wire into a blood vessel. The guide wire is advanced through the aorta to the aortic valve and then through the aortic valve.
Direct Flow Medical, Inc.

Systems for anticoagulating blood

Systems are provided for anticoagulating blood. Whole blood is drawn from a donor into a system at a draw flow rate.
Fenwal, Inc.

Novel indocyanine compound, synthesis method and purification method thereof, diagnostic composition using the indocyanine compound, and device for measuring biokinetics and device for visualizing circulation using the diagnostic composition

The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition.
National University Corporation Nagoya University

Tfpi inhibitors and methods of use

The invention provides peptides that bind tissue factor pathway inhibitor (tfpi), including tfpi-inhibitory peptides, and compositions thereof. The peptides may be used to inhibit a tfpi, enhance thrombin formation in a clotting factor-deficient subject, increase blood clot formation in a subject, treat a blood coagulation disorder in a subject, purify tfpi, an identify a tfpi-binding compound..
Baxalta Incorporated

Medicinal composition of amaranth extract origin having enriched nitrate content and a preparing the same

An extract of amaranth, having enriched nitrate content, l-arginine, flavonoids, saponins, alkaloids, carbohydrates, proteins, potassium, and with negligible amount of oxalic acid or oxalate content. The extract of amaranth can be prepared from fresh or dried leaves and stem of amaranth.
Arjuna Natural Extracts, Ltd.

Devices and methods for injectable vascular sclerofoams using a carrier matrix and uses thereof

The invention relates in particular to an injectable sclerosant drug foam comprising: (i) a matrix; (ii) at least one fluid; (iii) at least one sclerosant drug; (iv) a medical gas or medical gas mixture acceptable for intravenous use, (v) wherein said matrix has physical properties, which are comparable to denatured blood, wherein the denatured blood is obtainable from a fresh human venous whole blood sample of 1 ml volume, which is heated in a cylindrical polyethylene container with 3 mm inner diameter and 3.4 mm outer diameter for about 0.5 min. To about 10 min.
Swiss Vx Venentherapie Und Forschung Gmbh

Intravascular delivery of nanoparticle compositions and uses thereof

The present invention provides methods of delivering a composition comprising nanoparticles that comprise a macrolide and an albumin by directly injecting the nanoparticle composition into the blood vessel wall or the tissue surrounding the blood vessel wall. The methods can be used for inhibiting negative remodeling or vascular fibrosis in the blood vessel and are useful for treating various diseases..
Abraxis Bioscience, Llc

Devices and methods for pressure-responsive reshaping of blood vessels

A device for controlling blood flow through a vein is provided. The device includes a device body configured for implantation in or around the vein.
Sano V Pte Ltd

Apparatus and regulating tissue welder jaws

A surgical apparatus and methods for severing and welding tissue, in particular blood vessels. The apparatus includes an elongated shaft having a pair of relatively movable jaws at a distal end thereof.
Maquet Cardiovascular Llc

Intravascular catheter having an expandable incising portion and abrasive surfaces

An intravascular device is provided having a catheter tube and an expandable portion including a plurality of struts capable of being moved between an open and a closed position. An incising element and an abrasive surface are provided on at least one of the struts.

Method and system for cuff-less blood pressure (bp) measurement of a subject

Embodiments herein disclose a method and system for cuff-less blood pressure (bp) measurement of a subject. The method includes measuring, by one or more sensors, a local pulse wave velocity (pwv) and/or blood pulse waveforms of an arterial wall of the subject.
Healthcare Technology Innovation Centre

Contrast assisted intravascular ultrasound imaging

A method of imaging a blood vessel includes delivering a bubble-based contrast agent within the vessel and positioning at least one ultrasound device in the vicinity of the bubble-based contrast agent within the vessel. A first burst of low-frequency ultrasound energy can be delivered to excite the bubble-based contrast agent into oscillation within the vessel, and a second burst of high-frequency ultrasound energy can be delivered at the excited bubble-based contrast agent.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Simultaneous bi-lateral blood pressure system with position indicator

A simultaneous bi-lateral blood pressure system with position indicator has a dual input blood pressure monitor that allows a left and right blood pressure cuff to be plugged and to obtain left and right readings simultaneously. A position indicator attaches to a comfortable adjustable collar that attaches to a patient's neck and is retractably positioned to indicate the position of the reading to be taken.

Method and measuring hematocrit

The present disclosure provides a method and apparatus for measuring hematocrit of blood. The method includes measuring resistance data of a target blood sample; calculating a hematocrit estimation parameter for measuring hematocrit of the target blood sample using the resistance data; and determining a hematocrit estimation value using the hematocrit estimation parameter.
Gwangju Institute Science And Technology

Systems and methods for noninvasive blood glucose and other analyte detection and measurement using collision computing

In a noninvasive system for detection/measurement of glucose and other analytes in a medium such as tissue, spectra from the medium are deconstructed into features. Conditioned features, which contain frequency components specific to glucose or the other analytes, are derived from one or more features by modulating a carrier kernel with the feature.
Zyomed Corp.

Non-invasive blood glucose measuring device and measuring method using the same

A non-invasive blood glucose measuring device and a measuring method using the same are provided. The non-invasive blood glucose measuring device includes a signal emitting module, a delay component, a wave mixing component and a signal processor.
Industrial Technology Research Institute

Systems and methods for non-invasive blood pressure measurement

Systems and methods for non-invasive blood pressure measurement are disclosed. In some embodiments, a system comprises a wearable member configured to generate first and second signals, and a blood pressure calculation system.
Echo Labs, Inc.

Flow rate control apparatus and blood pressure monitor

A flow rate control apparatus includes a flow rate detection unit that detects the flow rate of a fluid flowing through a solenoid valve, a correlation storage unit that stores a correlation between a flow start point voltage at which the fluid starts to flow through a sample solenoid valve, which has substantially the same characteristic as the solenoid valve, and a limit voltage at which the sample solenoid valve is fully open, and a control unit that, when starting control of the flow rate of the fluid, changes the driving voltage of the solenoid valve, obtains the driving voltage at a time when the start of flowing of the fluid is detected as the flow start point voltage, and uses the correlation for the sample solenoid valve to set the driving voltage of the solenoid valve within a range between the flow start point voltage and the limit voltage.. .
Omron Healthcare Co., Ltd.

Continuous monitoring of blood glucose production and ongoing targeting of blood glucose production via nutritional support

Systems, techniques and methods for estimating the metabolic state or flux, e.g., the body energy state (“bes”) of a patient, are disclosed. The bes provides deep insight into the nutritional needs of the patient, thus allowing for a sort of exquisite glycemic control with regard to the patient.

Method and system for identifying bleeding

A method for identifying bleeding in a patient, comprising: receiving a four-dimensional data set comprising vascular voxels, each of the voxels representing a three-dimensional location of a time-varying signal; identifying the vascular voxels in the data set by comparing each time-varying signal of each voxel in the data set to a variance threshold; identifying, within the vascular voxels in the data set, blood vessel site voxels by comparing each time-varying signal of the vascular voxels to a model arterial and venous signals; generating clusters of voxels in the data set; separating the clusters of voxels into a subset of blood vessel site clusters and a subset of remaining clusters; identifying, within the subset of remaining clusters, one or more clusters that are spatially growing over time to determine one or more active bleed sites in the patient; and generating an alert if one or more active bleed sites are determined.. .
Ottawa Hospital Research Institute

Integration of a point-of-care blood analyzer into a prehospital telemedicine system

A prehospital telemedicine system comprises a physiologic monitor; an electronic patient care reporting system (epcr) system; and a point-of-care blood analyzer communicatively coupled to the physiologic monitor and the epcr system. The point-of-care blood analyzer is configured to perform an analysis of a blood sample based on an indication of a need for a specific blood analysis provided by one of the physiologic monitor and the epcr system, and to automatically transmit a result of the analysis to a remote data receiving system.
Physio-control, Inc.

Methods and kits for detecting brain injury

The disclosure provides methods of detecting and monitoring brain injury in a test subject comprising analyzing a blood sample from the test subject for increased levels of prpc. The disclosure also provides kits for measuring the amount of prpc in a blood sample..
University Of Saskatchewan

Erythrocyte aggregation and leukocyte isolation

A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component.
General Electric Company

Blood coagulation testing apparatus

A blood coagulation testing apparatus for determining compatibility between donor's blood and patient's blood before blood transfusion. The blood coagulation testing apparatus includes: a cylindrical main body connected at one end thereof to a supply tube for delivering donor's blood and connected at the other end thereof to a blood transfer tube for introduction of patient's blood, wherein the main body is divided into two sections by a barrier film extending in a longitudinal direction of the main body such that blood is introduced into the main body through two paths, wherein the donor's blood and the patient's blood are introduced into one of the two sections through one end of the main body and the other end of the main body, respectively, and wherein the barrier film is formed on a surface thereof with a blood coagulation indicator for checking coagulation..
Gwangju Institute Of Science And Technology

Test device for analyzing body fluids

A test instrument for analyzing body fluids such as blood or urine. The instrument includes a wound test tape which can be transported from a storage space into a waste space by advancing the tap.
Roche Diabetes Care, Inc.

Thin film-laminated film

The present invention provides the following thin film-laminated film that has high chemical stability even at low costs and that can preferably be used as an electrode film of a strip for a blood sugar level sensor. The thin film-laminated film including a film substrate, and a titanium thin film and a carbon thin film laminated in this order on at least one surface of the film substrate.
Toyobo Co., Ltd.

Method for expanding adult stem cells from whole blood

A method for expanding adult stem cells from blood is provided. The method includes growing and de-programming adult blood stem cells of a blood sample which has been obtained by in vitro treatment of the blood sample with macrophage colony stimulating factor (mcsf), and ozonization of the blood sample..
Thankstem S.r.l.

Hydrazine compound as blood coagulation factor xa inhibitor

Provided is a compound of formula (i) or a pharmaceutically acceptable salt thereof, wherein x is selected from a 3-9 membered carbon ring or a ring which is formed by 3-9 membered carbocyclic ring fused with benzo ring, and a 4-10 membered heterocyclic ring or a ring which is formed by 4-10 membered heterocyclic ring fused with benzo ring; y and z are independently selected from 4-9 membered saturated heterocyclic rings respectively; r1-3 are independently selected from h, f, cl, br, i, cn, oh, sh, nh2, cho, cooh respectively, or selected from the group, optionally substituted by r01, consisting of c1-10 alkyl, c1-10 heteroalkyl, c3-10 cyclohydrocarbyl, c3-10 heterocyclohydrocarbyl, c1-10 alkyl substituted by c3-10 cyclohydrocarbyl or c3-10 heterocyclohydrocarbyl, and c1-10 heteroalkyl substituted by c3-10 cyclohydrocarbyl or c3-10 heterocyclohydrocarbyl. The compound can be used as an anticoagulant for treating and preventing thrombotic disorders, and can meet the real needs of selectivity and a potent inhibitor for coagulation xa..
North China Pharmaceutical Company., Ltd.

Angioplasty device

Provided is a catheter system for intraluminal passages, including blood vessels, which includes a guidewire incorporating a work element, and an inflatable balloon enveloping the work element. The work element includes a lesion-smoothing member, which in a work configuration projects radially from a longitudinal axis of the balloon.

Methods and inserting multi-lumen split-tip catheters into a blood vessel

A method of performing a medical procedure, includes providing a catheter including a first lumen in fluid communication with a first distal opening and a second lumen in fluid communication with a second distal opening, advancing a distal end of a first intra-catheter stiffener element through the first lumen and out of the first distal opening, coupling the first intra-catheter stiffener element to the catheter, advancing a distal end of a second intra-catheter stiffener element through the second lumen and out of the second distal opening, coupling the second intra-catheter stiffener element to the catheter, and advancing the catheter into a patient.. .
Bard Access Systems, Inc.

Bone marrow aspirate enhanced bone graft

A method of preparing a bone graft. An osteoconductive matrix is placed in a receptacle.
Fortus Medical, Inc.

Hemostatic devices

Hemostatic devices for promoting blood clotting can include a substrate (e.g., gauze, textile, sponge, sponge matrix, one or more fibers, etc.), a hemostatic material disposed thereon such as kaolin clay, and a binder material such as crosslinked calcium alginate with a high guluronate monomer molar percentage disposed on the substrate to substantially retain the hemostatic material. When the device is used to treat a bleeding wound, at least a portion of the clay material comes into contact with blood to accelerate clotting.
Z-medica, Llc

Intranasal benzodiazepine pharmaceutical compositions

The present invention generally relates to intranasal pharmaceutical compositions comprising a benzodiazepine and methods of use thereof that can provide a therapeutic effect without a decrease in blood pressure and/or pulse after administration of the pharmaceutical composition.. .
Sk Biopharmaceuticals Co., Ltd.

Method and invasive device tracking using organ timing signal generated from mps sensors

Apparatus for generating an organ timing signal relating to an inspected organ within the body of a patient, including a medical positioning system, and a processor coupled with the medical positioning system, the medical positioning system including at least one reference electromagnetic transducer placed at a reference location, at least one inner electromagnetic transducer attached to a surgical tool inserted in a blood vessel in the vicinity of the inspected organ, and a medical positioning system processor coupled with the reference electromagnetic transducer and the inner electromagnetic transducer, the medical positioning system processor determining the three-dimensional position of the inner electromagnetic transducer, by processing transmitted electromagnetic signals transmitted from one of the reference electromagnetic transducer and the inner electromagnetic transducer with detected electromagnetic signals detected by the other of the reference electromagnetic transducer and the inner electromagnetic transducer, the medical positioning system processor further generating medical positioning system data sets, each of the medical positioning system data sets including a collection of three-dimensional position coordinate readings demonstrating the motion trajectory of the surgical tool over time, the processor generating the organ timing signal from the medical positioning system data sets by detecting and identifying periodic motion frequencies in the medical positioning system data sets, and filtering the periodic motion frequencies from the medical positioning system data sets.. .
Mediguide Ltd.

Methods and systems for delivering substances into luminal walls

Angioplasty and other dilatation devices are provided with scoring elements which incorporate a drug to be delivered to a body lumen, typically a blood vessel. The scoring elements have drugs and other active substances coated over a portion thereof or incorporated within internal structure of the element so that the drug is released into the luminal wall closely associated diseased regions of the body lumen as the scoring structure is radially expanded into the wall..
Angioscore, Inc.

A automatic blood flow control, automatic blood flow control system and a tourniquet

The subject of the invention is a method for automatic control of blood from the damaged vessel to be used in a dressing system provided with a tourniquet, a bandage and the first compression element. The method comprises the stage of applying pressure exceeding the systolic blood pressure of the patient via the compression element to a lesion site, so that the blood stops flowing through the damaged vessel, then the stage of reducing the pressure.
Instytut Kardiologii Im. Prymasa Tysiaclecia

Apparatus for estimating blood component level using spectrum analysis

An apparatus for estimating a blood component level, such as a blood neutral fat level or blood sugar level, is provided. The apparatus may include: a light source configured to emit a light toward a skin; a spectrometer configured to spectrally disperse the light reflected from the skin; a detector configured to detect a spectrum of the spectrally dispersed light to extract spectrum data for each wavelength; and a controller configured to apply the extracted spectrum data and a reference blood component level corresponding to the spectrum data to a first level estimation model to estimate a target blood component level.
Samsung Electronics Co., Ltd.

Biological-information detecting apparatus, seat with backrest, and cardiopulmonary-function monitoring apparatus

A biological-information detecting apparatus includes a first blood-flow measuring device provided at a seat surface of a seat, the first blood-flow measuring device measuring a condition of a blood flow of a popliteal artery of a measurement subject seated in the seat, a second blood-flow measuring device provided at a back of the seat, the second blood-flow measuring device measuring a condition of a blood flow of a thoracic aorta of the measurement subject, and a blood-pressure calculation device determining a pulse-wave propagation velocity and a degree of arteriosclerosis from blood flow data acquired by the first blood-flow measuring device and blood flow data acquired by the second blood-flow measuring device and calculating blood pressures of the popliteal artery and the thoracic aorta of the measurement subject based on the pulse-wave propagation velocity and the degree of arteriosclerosis.. .
University Of Tsukuba

Mapping and quantifying blood stasis and thrombus risk in the heart

The present disclosure provides methods for in-vivo assessment of the location and extent of blood flow stasis regions inside a cardiac chamber or blood vessel and systems for performing the methods. The disclosure provides methods for assessing risk of intracardiac or intravascular thrombus or of embolism originating in a cardiac chamber or vessel, and methods for assessing the need for and/or optimization of cardiac resynchronization therapy..
Fundación Para La Investigación Biomédica Del Hospital Gregorio Marañó

Alarm system that processes both motion and vital signs using specific heuristic rules and thresholds

The invention provides a body-worn monitor that measures a patient's vital signs (e.g. blood pressure, spo2, heart rate, respiratory rate, and temperature) while simultaneously characterizing their activity state (e.g.

Method for sorting nucleated red blood cell

A method for sorting nucleated red blood cells, the method includes: selecting a candidate cell of nucleated red blood cells in accordance with shapes of cells; setting a search range including the candidate cell and selecting a white blood cell within the search range; defining that the candidate cell is a nucleated red blood cell through comparison of spectral characteristics of hemoglobin between the candidate cell and the white blood cell; and sorting the nucleated red blood cells into mother-derived nucleated red blood cells or fetus-derived nucleated red blood cells through comparison of an allele contained in the nucleated red blood cell after the defining of the nucleated red blood cell with an allele contained in a white blood cell which has not been selected in the selecting of the candidate cell or in the white blood cell selected in the selecting of the white blood cell.. .

Resonant frequency hemostasis analyzer

A device for blood hemostasis analysis is disclosed. A blood sample is displaced to reach a resonant state.

Method for sorting nucleated red blood cell

Provided is a method for sorting nucleated red blood cells in which fetus-derived nucleated red blood cells are sorted out from maternal blood. The method includes a nucleated red blood cell specification step of specifying nucleated red blood cells to be sorted out; a reference red blood cell selection step of setting a search range including the nucleated red blood cells and selecting red blood cells having no nucleus within the search range as reference red blood cells; and a sorting step of sorting the nucleated red blood cells into mother-derived nucleated red blood cells and fetus-derived nucleated red blood cells in accordance with spectral characteristics attributable to oxygen affinity of hemoglobin of the nucleated red blood cells and the reference red blood cells..

Diagnostic devices and methods

A diagnostic device is provided that comprises a light source for transmitting a light beam through a blood sample to a light detector, and a permanent magnet, wherein one of the permanent magnet and blood sample is automatically movable relative to the other between a “high” magnetic state position and a “low” magnetic state position, such that a substantially high magnetic field is applied to the blood sample causing any hemozoin in the blood sample to tend toward perpendicular orientation to the substantially magnetic field and the suppression, or enhancement of light based on its polarization, and a zero-to-near-zero magnetic field is applied to the blood sample causing the randomization of any hemozoin in the blood sample and a baseline amount of light to pass through the blood sample in the “low” magnetic state position.. .

Method for inspecting chromosome of fetus

A method for inspecting a chromosome of a fetus includes: a collection step of obtaining maternal blood from a pregnant mother; a concentration step of concentrating nucleated red blood cells in the maternal blood; a sorting step of sorting the nucleated red blood cells in the maternal blood, in which the nucleated red blood cells are concentrated through the concentration step, into mother-derived nucleated red blood cells and fetus-derived nucleated red blood cells in accordance with the shapes of nuclei and spectral characteristics at wavelengths included in a light wavelength region of 400 to 650 nm; an amplification step of amplifying a nucleic acid of a chromosome of the nucleated red blood cells; a definition step of defining an amount of the amplified product of the nucleated red blood cells; and a determination step of determining presence or absence of a numerical abnormality of the fetus-derived chromosome.. .

Single spin process for blood plasma separation and plasma composition including preservative

A screening method for the identification of a characteristic of a target nucleic acid in a whole blood sample, including positioning a composition comprising whole blood and at least one preservative agent within a centrifuge, centrifugating the composition to isolate a plasma that includes at least one target nucleic acid for further analysis and analyzing the at least one target nucleic acid to identify a characteristic about the at least one target nucleic acid, and a composition including the plasma, the preservative agent, and any other ingredient, which is produced by the method.. .

Antibody substituting for function of blood coagulation factor viii

The present inventors produced a variety of bispecific antibodies that specifically bind to both f. Ix/f.

Medical device and providing information for glycemic control

A medical device for providing information for glycemic control is provided, wherein the device comprises storage means arranged to store data, receiving means arranged to receive blood glucose value data and security data, data processing means arranged to execute a first processing function for modifying data retrieved from the storage means and to execute a second processing function for providing information for glycemic control based on the blood glucose value data and data retrieved from the storage means, validating means arranged to validate the received security data and to provide validation data corresponding to the validation of the received security data, and safety means arranged to control an execution of at least a predetermined function out of the first and second processing functions based on the validation data.. .

Dual lumen retrograde catheter and hub attachment

Disclosed is a dual lumen retrograde catheter and hub attachment for dialysis. The catheter includes a venous lumen and an arterial lumen that are attached to a proximal hub having at least one luer extension extending therefrom.

Cellular micromotors and uses thereof

Living cells, such as red blood cells (rbcs) modified with functional micromotors with the aid of ultrasound propulsion and magnetic guidance. Iron oxide nanoparticles are loaded into the rbcs, where their asymmetric distribution within the cells results in a net magnetization, thus enabling magnetic alignment and guidance under acoustic propulsion.

Calcitonin mimetics for treating diseases and disorders

Calcitonin mimetic peptides having an amino acid sequence in accordance with seq id no:8 or seq id no:53, each of which may be carboxylated at its n-terminal or otherwise modified to reduce the positive charge of the first amino acid and independently of that may be amidated at its c-terminal, and in each of which the 1 and 7 position cysteine residues may together be replaced by α-aminosuberic acid (asu) are useful as medicaments for treating diabetes (type i and/or type ii), excess bodyweight, excessive food consumption, metabolic syndrome, rheumatoid arthritis, non-alcoholic fatty liver disease, osteoporosis, or osteoarthritis, poorly regulated blood glucose levels, poorly regulated response to glucose tolerance tests, or poorly regulated of food intake.. .

Inhalation of nitric oxide for treating respiratory diseases

A method of treating a human subject which is effected by intermittent inhalation of gaseous nitric oxide at a concentration of at least 160 ppm is disclosed. The method can be utilized for treating a human subject suffering from, or prone to suffer from, a disease or disorder that is manifested in the respiratory tract, or from a disease or disorder that can be treated via the respiratory tract.

Coating composition and medical device

A coating composition for drug-eluting medical devices, which enables a medical device to be delivered to a target tissue for the purpose of treating an affected blood vessel part such as restenosis, without easy separation of a drug from the medical device during the delivery process is provided. The coating composition for drug-eluting medical devices contains a water-insoluble drug and at least one selected from the group consisting of ester compounds of amino acids, which have a hydropathy index of the amino acid of zero or less than zero, and salts thereof.

Intravascular device for hemiarch repair and associated method

Vascular devices and methods for addressing pathologies in the hemiarch of the aorta are provided. The device includes a main body (110) and a secondary body (120).

Catheter with omni-directional optical lesion evaluation

A catheter is adapted to ablate tissue and provide lesion qualitative information on a real time basis, having an ablation tip section with a generally omni-directional light diffusion chamber with one openings to allow light energy in the chamber to radiate the tissue and return to the chamber. The chamber is irrigated at a positive pressure differential to continuously flush the opening with fluid.

Improved atherectomy device

An atherectomy device comprising a rotatably motor-driven flexible hollow shaft that is coaxial with a longitudinal axis of the guidewire; an annular distal end of the hollow shaft having a diameter that is only slightly larger than the diameter of the guidewire and configured with cutting surfaces for piercing hardened atherosclerotic plaque! a tubular sleeve secured to a first peripheral surface of the hollow shaft and configured with cutting surfaces for enlarging an opening formed in the plaque; and an asymmetric cutting unit extending between the sleeve and a second peripheral surface of the hollow shaft, to enable eccentric rotation of the hollow shaft for cutting and removing additional occlusive material from the blood vessel to open a chronic total occlusion. In one embodiment, the cutting unit is a helical strand unit having a polygonal cross section with a first side that atraumatically contacts a blood vessel wall..

Axial lengthening thrombus capture system

Systems and methods can remove material of interest, including blood clots, from a body region, including but not limited to the circulatory system for the treatment of pulmonary embolism (pe), deep vein thrombosis (dvt), cerebrovascular embolism, and other vascular occlusions.. .

Micrograft for the treatment of intracranial aneurysms and use

A device for occluding a vasculature of a patient including a micrograft having an absorbent polymeric structure with a lumen of transporting blood. The micrograft has a series of peaks and valleys formed by crimping.

Intravascular imaging and guide catheter detection methods and systems

In part, the disclosure relates to computer-based methods, devices, and systems suitable for detecting a delivery catheter using intravascular data. In one embodiment, the delivery catheter is used to position the intravascular data collection probe.

Determination and application of glucose sensor reliability indicator and/or metric

Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor..

Performance reports associated with continuous sensor data from multiple analysis time periods

A method of providing performance reports to persons associated with the monitoring of an analyte level, such as blood glucose concentrations in a host, is provided. The performance reports can indicate a measure of an analyte variability of the host over a first analysis time period compared to a measure of analyte variability of the host over one or more other analysis time periods.

Blood glucose management system

A biological property testing device includes a base comprising a primary surface extending in a base plane, and a first lancet station supported by the base. A first test strip channel provided in the base can have a main channel portion extending generally parallel with the base plane, and an angled channel portion that forms an angle with the main channel portion between 5 degrees and 90 degrees.

Method and system for non-invasive optical blood glucose detection utilizing spectral data analysis

Systems and methods are disclosed for non-invasively measuring blood glucose levels in a biological sample based on spectral data. This includes utilizing at least one light source configured to strike a target area of a sample, utilizing at least one light filter positioned to receive light transmitted through the target area of the sample from the at least one light source, utilizing at least one light detector positioned to receive light from the at least one light source and filtered by the at least one light filter, and to generate an output signal, having a time dependent current, which is indicative of the power of light detected, receiving the output signal from the at least one light detector with a processor, calculating the attenuance attributable to blood with a ratio factor based on the received output signal, and determining a blood glucose level based on the calculated attenuance..

Emergency medical alert wearable

An emergency medical alert wearable. The wearable includes sensors that are configured to monitor various physiological parameters of the wearer, including blood pressure and heart rate.

Blood pressure measurement cuff and attachment method thereof

A blood pressure measurement cuff includes a belt-shaped body and a ring having a temporary fastening structure that allows a region continuous with the outer circumferential end of the belt-shaped body to be pulled through the ring away from the measurement site during attachment and suppresses a case in which the region continuous with the outer circumferential end of the belt-shaped body is pulled back through the ring by elastic force of the measurement site. The temporary fastening structure includes a sleeve member fitted around a second side of the ring for pivoting around the second side.

Biological measurement apparatus and biological measurement method

A biological measurement apparatus includes a first detecting section including a first infrared sensor radiating an infrared ray on an arm, receiving the infrared ray reflected from the arm, and outputting light intensity data and a first force sensor detecting a contact force between the first infrared sensor and the arm, a second detecting section including a second infrared sensor and a second force sensor, a holding section holding the first detecting section and the second detecting section such that the first and second infrared sensors contact the arm, a pressing-force determining section comparing the force with a determination value and determining whether the force is within a predetermined range, and a component-concentration calculating section calculating a blood sugar level using the light intensity data when the pressing-force determining section determines that the contact force is within the predetermined range.. .

Portable blood glucose measurement device

A portable blood glucose measurement device is provided. The device includes, in an externally exposed way, a temperature measurement medium of which the temperature quickly changes according to outside temperature changes provided on one side surface of a case.
I-sens, Inc.

Blood coagulation system analysis device, and method and program for analysis of blood coagulation system

The blood coagulation system is observed as a temporal change in permittivity before the viscoelasticity manifestation timing (timing at which blood starts to clot from the viewpoint of viscoelasticity (in greater detail, timing at which active polymerization of fibrin monomers starts)). A permittivity of blood which is positioned between a pair of electrodes is measured at predetermined time intervals after the anticoagulant effect acting on the blood is ended, and from the measurement result, a degree of the action of the blood coagulation system is analyzed..

Biological component information measurement device

In the present invention, without decreasing measurement accuracy, a biological component information measurement device can have a miniaturized device structure. In a biological component information measurement device (100), a sample container (104) accommodates a measurement target (105) such as blood, cultured cells, or urine, and a light from a light source (101) is separated into spectral components using a rotating diffraction grating (110) and caused to be incident on the measurement target (105).
Mitsumi Electric Co., Ltd.

Physiogenomic predicting drug metabolism reserve for antidepressants and stimulants

Disclosed herein are compositions and methods relevant to a novel drug metabolism reserve physiotype to determine the metabolic capacity of a human individual. The drug metabolism reserve physiotype allows the determination of the innate metabolic capacity of the patient relevant to antidepressant and stimulant treatment and can be predicted and diagnosed simply from a blood sample.
Genomas, Inc.

Nucleic acid sample preparation

The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples..
Biological Dynamics, Inc.

Compositions and methods for treating diabetes

Compositions containing an fkbp 11 peptide (i.e., fkbp11 polypeptide, a variant or a fragment thereof), a fusion protein containing an fkbp11 peptide, or a nucleic acid encoding an fkbp 11 peptide are disclosed. Also disclosed are methods of reducing blood glucose levels, improving glucose tolerance, decreasing hepatic gluconeogenic activity and/or improving insulin sensitivity in a subject, by administering a composition containing an fkbp 11 peptide or a fusion protein containing an fkbp11 peptide.
The Children's Medical Center Corporation

Methods and compositions for treating ineffective erythropoiesis

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and/or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.. .
Acceleron Pharma Inc.

Microfluidic device

Described herein are particular embodiments relating to a microfluidic device that may be utilized for cell sensing, counting, and/or sorting. Particular aspects relate to a microfabricated device that is capable of differentiating single cell types from dense cell populations.
California Institute Of Technology

Vascular access device and use thereof

The present invention generally relates to device and system for facilitating vascular access into a vessel of a patient and to a method of using such a device or system. In one embodiment, the vessel is a vein and the device is used to facilitate obtaining a blood sample..
Cook Medical Technologies Llc

Blood treatment cassette with film valve and inelastical spacer as well as blood treatment apparatus

A blood treatment cassette having a cassette body, designed as a hard part, and a film, wherein the film is connected with the hard part and covers the hard part at least partially, wherein the hard part comprises at least one valve base of a valve and wherein the valve is embodied to take, in addition to a first, open position of the valve in which the valve base and the section of the film that is arranged above it do not touch each other, a second, closed position of the valve when applying force on the section of the film in which the valve base and the section of the film touch each other.. .
Fresenius Medical Care Deutschland Gmbh

Flexible biological fluid filters

Filter assemblies are processing biological fluid, such as blood or a blood component containing leukocytes. The filter assemblies include a flexible housing with first and second walls.
Fenwal, Inc.

Thioredoxin or thioredoxin derivatives or peptides for the treatment of high blood pressure

The present invention provides methods and compositions for the treatment of cardiovascular disorders comprising: a therapeutically effective amount of thioredoxin-1 or a thioredoxin-1 derivative in a pharmaceutical carrier to ameliorate one or more symptom of a cardiovascular disorder.. .
Texas Tech University System

Water extracts of cinnamon and radix astragali

This invention relates to methods and compositions for providing improved insulin-sensitivity and/or enhanced insulin-like action, which leads to improved glucose uptake and utilization. This invention also relates to methods and compositions for lowering ldl, lowering triglycerides, increasing hdl, and lowering high blood pressure in a subject.

Composition for regulating blood sugar

The present invention provides a composition for regulating blood sugar. The composition comprises at least one yellow pigment extracted from a red mold product, wherein the said yellow pigment is monascin, ankaflavin, or combination of monascin and ankaflavin.
Sunway Biotech Co., Ltd

Sensory stimulation or monitoring the back of neck

Described herein are wearable sensory stimulation and monitoring devices that can be worn around the back of the neck along and in contact with the spine. Apparatuses described herein stimulate one or more senses including auditory, tactile or olfactory.
Copa Animal Health, Llc

Devices and methods for control of blood pressure

Apparatus and methods are described, including identifying a subject as suffering from hypertension. In response to the identifying (a) a radius of curvature of a first set of at least three regions of an arterial wall of the subject is increased at a given longitudinal location, while (b) allowing the first set of regions of the arterial wall to pulsate.
Vascular Dynamics, Inc.

Coated tracheostomy tube and stoma stent or cannula

The present invention relates to devices used in the management of bodily airways including tracheostomy tubes, laryngectomy tubes, bronchial stents, bronchial y-tubes, bronchial ty-tubes, and nasal stents. The devices may comprise a protective coating to prevent the accumulation of mucus, crusting and granulation on or around airway management devices, as well as prevent adhesion to tissues which can cause bleeding upon removal, and prevent build-up of blood, or blood clots, to the stent..
E. Benson Hood Laboratories

Coaptive surgical sealing tool

A coaptive surgical sealing tool may be similar to an ordinary hemostat with long (50, 60, 70 or 80 mm) thin jaws for sliding into the liver parenchyma, without tearing the larger blood vessels. The jaws are spring loaded and are designed for uniform compression, and to avoid closing too quickly.
City Of Hope

Shock wave electrodes

Disclosed herein shock wave catheters comprising one or more shock wave electrodes for cracking calcifications located within blood vessels. In some variations, a shock wave catheter has first and second shock wave electrodes each circumferentially disposed over the outer surface of the catheter.
Shockwave Medical, Inc.

Sheath delivering a closure device

An apparatus for delivering a clip includes an introducer sheath including an outer surface extending between its proximal and distal ends. A clip is carried on the outer surface, e.g., on a carrier assembly that is slidable along the outer surface from the proximal end towards the distal end.
Integrated Vascular Systems, Inc.

Disease prediction model construction apparatus and method, and disease prediction apparatus

A disease prediction model construction apparatus is provided. The disease prediction model construction apparatus may include a spectral data acquisition unit that emits near-infrared rays toward a skin of a subject to acquire near-infrared spectral data and a prediction model construction unit that constructs a disease prediction model based on a time-blood glucose graph generated from the acquired near-infrared spectral data..
Samsung Electronics Co., Ltd.

Gigahertz frequency fringing near-field cardiovascular sensor

A near-field sensor method and device for obtaining cardiovascular information is disclosed. A transmission-line aperture arrangement configured to guide electromagnetic waves and emit near-field fringing energy, is placed near the skin.

Strain sensing element, pressure sensor, microphone, blood pressure sensor, and touch panel

According to one embodiment, a strain sensing element provided on a deformable substrate includes: a first magnetic layer; a second magnetic layer; a spacer layer; and a bias layer. Magnetization of the second magnetic layer changes according to deformation of the substrate.
Kabushiki Kaisha Toshiba

Blood pressure estimation method and blood pressure measurement device

A blood pressure measurement device (1) is provided with a pulse wave measurement unit (20) for measuring the pulse wave of a subject using an fbg sensor (10), and a blood pressure value calculation unit (30) for calculating a blood pressure value from waveform date of the measured pulse wave. The blood pressure calculation unit (30) uses a calibration model representing the correlation between measured waveform date of a previously measured pulse wave, and a measured blood pressure value measured by an automatic blood pressure gauge at each measurement point in time of the measured waveform date to estimate the blood pressure value of the subject from the measured waveform date of the pulse wave.
Shinshu University

Magnetic resonance imaging apparatus and blood flow drawing method

To obtain an image having high ability of imaging a blood vessel in each cardiac time phase when performing imaging through a cine-pc method, an mri apparatus includes a magnetic resonance imaging unit that collects a magnetic resonance signal; a control unit that controls the magnetic resonance imaging unit as per a pulse sequence; and a signal processing unit that prepares an image of a test target by using the magnetic resonance signal collected by the magnetic resonance imaging unit, and time phase information related to a motion of the test target. The control unit has an imaging sequence which serves as the pulse sequence, which includes applying of a flow encoding pulse, and in which an echo signal is acquired for each time phase.
Hitachi, Ltd.

Method for acquiring t2* and vascular images from magnetic resonance imaging system

According to the present invention, accurate t2* and vascular images are concurrently acquired by acquiring a t2* image without a flow compensation and a t2* image with a flow compensation and subtracting the two images to reconstitute an image showing the flow phenomenon. Furthermore, an accurate t2* image can be acquired by using the readout gradient without the flow compensation and also the accurate t2* and vascular images can be concurrently acquired.
Gil Medical Center

Blood pressure monitor coordinated with a cardiovascular health condition monitoring module

A blood pressure monitor equipped with a cardiovascular health condition monitoring module includes: a blood pressure measurement device measuring a user's blood pressure signal; a host including a blood pressure monitor microprocessor that processes blood pressure correlated signal; a control panel equipped to the host and configured to control blood pressure measured by the blood pressure monitor and heart rhythm analysis; a first display device displaying blood pressure result; and a second display device displaying heart rhythm analysis from the cardiovascular health condition monitoring module.. .
Acme Portable Machines, Inc.

System and estimating arterial pulse wave velocity

A method for determining an arterial pulse wave velocity representative of a health condition of a blood vessel includes receiving an image data set comprising a plurality of images of a subject, from an imaging modality. The method also involves determining a blood vessel region in an image from the plurality of images.
General Electric Company

Analyzing digital holographic microscopy data for hematology applications

A method for analyzing digital holographic microscopy (dhm) data for hematology applications includes receiving a plurality of dhm images acquired using a digital holographic microscopy system. One or more connected components are identified in each of the plurality of dhm images and one or more training white blood cell images are generated from the one or more connected components.
Siemens Healthcare Diagnostics Inc.

Fast method to analyse blood samples for the identification of hemoglobin variants using electron transfer dissociation

A method of screening or testing a sample is disclosed that comprises ionising a native human hemoglobin sample to generate parent or precursor ions, subjecting the parent or precursor ions to electron transfer dissociation fragmentation so as to generate a plurality of fragment ions, mass analysing the fragment ions and determining whether or not the fragment ions include fragment ions which are indicative of a variant of hemoglobin.. .
Micromass Uk Limited

Test strip for holding reagents to determine blood glucose level

This invention relates to a test strip for holding reagents to determine blood glucose level, said strip comprising a) a plasma separator membrane which is a composite membrane for separation of plasma from whole blood, said plasma separator membrane containing an enzyme mix specific to the analyte, said analyte being glucose, a substrate which reacts specifically with one of the products of the enzymatic reaction of the analyte with the enzyme mix, b) a reaction membrane containing an enhancer mix of metallic ions, which enhances the color developed due to the enzymatic reaction.. .
Birla Institute Of Technology And Sciences

Breath acetone monitor and detecting breath acetone

A breath acetone meter is provided. The blood glucose meter includes a receiver comprising a first polymer and a second plurality of layers arranged in an alternating arrangement.
Western New England University

Method and detecting undesired measurement conditions

The invention relates to a method and apparatus for detecting undesired measurement conditions in a sample container. The method comprises measuring a fluorescent property of the sample container comprising a sample substrate with impregnated blood sample and incubation buffer to which the blood sample is to be eluted, and determining, based on temporal and/or spectral characteristics of the fluorescent property, whether the fluorescent property is characteristic to a sample container comprising a sample substrate and incubation buffer under said undesired measurement conditions or to a sample container suitable for optical measurement of analyte contained in the sample.
Wallac Oy

Method for diluted plasma separation using container for blood dilution and storage containing gelling agent for plasma separation

A method for separating plasma in a minute amount of a blood sample diluted with a blood dilution buffer is provided. When a blood dilution buffer is added to a minute amount of blood (about 20 to 100 μl) so as to assay the biological blood components in the resulting diluted plasma, it is necessary to separately store and transfer the diluted blood cell component and the diluted plasma component.
Leisure, Inc.

Methods for predicting acute rejection in heart recipients

The present invention relates to method for predicting acute rejection in heart recipients. In particular, the present invention relates to a method for predicting acute rejection in a heart recipient comprising the steps consisting of i) determining the expression level (eli) of at least one mirnai selected from the group consisting of mir-155, mir-10a, mir-92a and mir-31 in a blood sample obtained from the heart recipient, ii) comparing the expression level (eli) determined at step i) with a predetermined reference level (elri) and iii) and concluding that the recipient has a high risk of developing acute rejection when the level the expression level (eli) determined at step i) is different (higher or lower) than the predetermined reference level (elri)..
Assistance Publique-hopitaux De Paris (aphp)

Compositions and methods of preparation

Methods of preparing platelet-rich plasma (prp) compositions are disclosed which include adding cd34+ cells to the prp composition. In addition, the concentration of stromal-derived factor-1 (sdf-1) in the prp composition may be adjusted to a pre-determined value.

Human antibodies to the glucagon receptor

The present invention provides antibodies that bind to the human glucagon receptor, designated gcgr and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human gcgr.
Regeneron Pharmaceuticals, Inc.

Method for improving the oxygen-releasing ability of hemoglobin to organs or peripheral tissues in human bodies and a medication thereof

A method for improving the oxygen-releasing ability of hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes to organs or peripheral tissues in human bodies is disclosed by administering a compound of phthalides to a subject in need thereof. The compound of phthalides is characterized by a phthalide functional group which is represented as formula i, and forms at least one hydrogen bond with αarg141 of hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes, stabilizing the α1/α2 interface of hemoglobin, further stabilizing the oxygenated hemoglobin, hemoglobin variants, recombinant hemoglobin or hemoglobin-based blood substitutes in the low oxygen affinity “t” state and facilitating the oxygen release to the organs or the peripheral tissues.
National Sun Yat-sen University

Metal filter and concentrating cancer cells

A metal filter includes a plurality of through holes. An opening shape of each of the plurality of through holes is a rectangle or rounded-rectangle and a length of a short side of the rectangle or a rounded rectangle is 5 to 15 μm.
Hitachi Chemical Company, Ltd.

Blood control catheter valve employing actuator with flexible retention arms

The present invention extends to a blood control catheter valve for use in a catheter adapter. The blood control catheter value employs an actuator for bypassing a septum to open the blood control catheter valve.
Becton, Dickinson And Company

Specially designed magnesium-aluminum alloys and medical uses thereof in a hemodynamic environment

The present invention relates generally to specially designed magnesium-aluminum (“mg—al”) alloys and medical uses thereof in a hemodynamic environment, and, more particularly to devices for sealing an opening formed through biological tissue (such as blood vessels) made from such specially designed magnesium-aluminum alloys.. .
Transluminal Technologies, Llc

In situ tissue engineering

The present disclosure relates to in situ tissue engineering, more specifically in situ vascular tissue engineering with the aim of providing a tissue structure which can be used e.g. As a substitute blood vessel or as a blood vessel functioning as cannulation site in hemodialysis.
Universiteit Maastricht

Sealant formulation and uses thereof

The present invention relates to a sealant formulation comprising a blend containing fibrinogen and an exogenous activator of a member of a mammalian blood clotting cascade.. .
Ethicon, Inc.

Methods of treating anorexia nervosa by intranasal administration of insulin

The present system is directed in several embodiments to a method of administration of a therapeutic composition for treatment of anorexia nervosa, safely and without significantly affecting the blood glucose or blood insulin levels of the patient. The method includes administering one or more therapeutic compositions comprising an effective amount of insulin directly to the subject patient's cns, with no to minimal systemic exposure.
Healthpartners Institute

Non-aqueous glucagon formulations

The compositions can be used to treat subjects with very low blood sugar (severe hypoglycemia) that can happen in subjects who have diabetes and use insulin.. .

Nutritional supplements affecting mood state

Nutritional supplement compositions for mood enhancement are disclosed. A nutritional supplement composition can include one or more of plant material from pine bark, plant material from a species of the genus ephedra, caffeine, green tea, octopamine, quercetin, trimethylglycine, yohimbine, and niacin.

Stent

The present invention provides a stent that can obtain sufficient strength while an inner side of the stent is easily endothelialized and moreover, can prevent occlusion of a branch blood vessel. Specifically, a stent body capable of diameter expansion is provided.
The School Corporation Kansai University

Measurement system

A measurement system may comprise a sensor wire and a transceiver unit. The sensor wire may comprise an insertable portion configured to be inserted in a blood vessel of a patient's body and two sensors disposed within the insertable portion at a distal end of the sensor wire.
St. Jude Medical Coordination Center Bvba

Intravascular arterial to venous anastomosis and tissue welding catheter

A catheter-based device tracks over a guidewire which has been placed from a first blood vessel into a second blood vessel. The distal tip of the catheter is advanced into the second vessel while a proximal member remains in the first vessel.
Avenu Medical, Inc.

Vascular re-entry device

An ultrasonic device having a tri-axial configuration including an ultrasound transmission member, a dilator, and a sheath is disclosed. The ultrasound device may be used in a procedure to treat an occluded blood vessel.
C.r. Bard, Inc.

Sutureless anastomosis device

A sutureless anastomosis device is provided herein comprising an outer tube defining an outer lumen and an inner tube formed of a compliant material defining an inner lumen. The inner tube is disposed within the outer lumen.
The Regents Of The University Of California

Heart rate monitor system and determining a warming-up status of a user

Heart rate monitor system and method of determining a warming-up status of a user a heart rate monitor system is provided which comprises an optical heart rate sensor (100) configured to measure or determine a heart rate of a user and to output an output signal (101). The heart rate monitor system furthermore comprises an analyzing unit (200) configured to analyze an output signal (101) from the heart rate sensor (100) and to determine a warming up status of a user based on the analyzed output signal (101) from the optical heart rate sensor (100), wherein the analyzing unit (200) comprises a signal analyzer (210) configured to analyze at least one of an ac component of the output signal (101), a dc component of the output signal (101), and a pulse morphology of the output signal (101) and a warm-up detector unit (220) configured to detect a warm-up status of the user based on a detected blood perfusion according to signal characteristics of the ac component, the dc component or the pulse morphology of the output signal (101)..
Koninklijke Philips N.v.

Smart phone having functions of diagnosing and treating illness

Smart phones capable of detecting electrical impedances of and providing electronic pulse stimuli to acupuncture points located on a human body are disclosed. An example smart phone is equipped with a hardware diagnosis module and a hardware treatment module that function based on the principle of holography of protruding parts of the human body, in addition to having regular smart phone functions.

Analytical system for examining a body fluid and the operation of an analytical system

An analytical system for examining a body fluid and a method of operation of an analytical system, typically for blood sugar tests, including an exchangeable magazine (18) as a consumable, which includes a plurality of magazine units (24) that are each provided with at least one analytical aid (32, 34) and with a transport element (28), a hand-held device (12) having a magazine guide (16) for receiving the magazine (18), a transport mechanism (48) that engages on the transport elements so as to transport the magazine in steps in the magazine guide, including a positioning mechanism (50) for positioning an active magazine unit in a predefined functional position, wherein retaining means (52, 54) of the positioning mechanism can be brought into engagement with transport elements of the magazine.. .
Roche Diabetes Care, Inc.

Continuous analyte monitor data recording device operable in a blinded mode

A system is provided for monitoring analyte in a host, including a continuous analyte sensor that produces a data stream indicative of a host's analyte concentration and a device that receives and records data from the data stream from the continuous analyte sensor. In one embodiment, the device includes a single point analyte monitor, from which it obtains an analyte value, and is configured to display only single point analyte measurement values, and not any analyte measurement values associated with data received from the continuous analyte sensor.
Dexcom, Inc.

Use as rodenticides of compounds that inhibit blood coagulation

The invention relates to a use, a method and a poison in which a thrombin inhibitor, a thrombin receptor antagonist, a factor xa inhibitor, a pai (plasminogen activator inhibitor), a p2y12 adp receptor antagonist or a gpiib/iiia receptor antagonist are used as rodenticide.. .

Data backfilling for continuous glucose monitoring

Methods and apparatus, including computer program products, are provided for backfilling. In some example embodiments, there is provided a method that includes receiving, at a receiver, backfill data representative of sensor data stored, at a continuous blood glucose sensor and transmitter assembly, due to a loss of a wireless link between the receiver and the continuous blood glucose sensor and transmitter assembly; generating, at the receiver, at least one of a notification or a graphically distinct indicator for presentation at a display of the receiver, the at least one of the notification or the graphically distinct indicator enabling the backfill data to be graphically distinguished, when presented at the display, from non-backfill data; and generating, at the receiver, a view including the backfill data, the non-backfill data, and the generated at least one of the notification or the graphically distinct indicator.
Dexcom, Inc.

Integrated physical activity level (i-pal) measurement and tracking in adolescents and older teenagers

Described are systems that include at least one sub-system to track, measure, monitor and reward adolescents and young adults for performing daily physical activities, which include before-school, in-school, after-school, sports and activities of daily living. The system offers adolescents the opportunity to track their integrated physical activity level (i-pal) scores over their adolescent years.

Data backfilling for continuous glucose monitoring

Methods and apparatus, including computer program products, are provided for backfilling. In some example embodiments, there is provided a method that includes receiving, at a receiver, backfill data representative of sensor data stored, at a continuous blood glucose sensor and transmitter assembly, due to a loss of a wireless link between the receiver and the continuous blood glucose sensor and transmitter assembly; generating, at the receiver, at least one of a notification or a graphically distinct indicator for presentation at a display of the receiver, the at least one of the notification or the graphically distinct indicator enabling the backfill data to be graphically distinguished, when presented at the display, from non-backfill data; and generating, at the receiver, a view including the backfill data, the non-backfill data, and the generated at least one of the notification or the graphically distinct indicator.
Dexcom, Inc.

Data backfilling for continuous glucose monitoring

Methods and apparatus, including computer program products, are provided for backfilling. In some example embodiments, there is provided a method that includes receiving, at a receiver, backfill data representative of sensor data stored, at a continuous blood glucose sensor and transmitter assembly, due to a loss of a wireless link between the receiver and the continuous blood glucose sensor and transmitter assembly; generating, at the receiver, at least one of a notification or a graphically distinct indicator for presentation at a display of the receiver, the at least one of the notification or the graphically distinct indicator enabling the backfill data to be graphically distinguished, when presented at the display, from non-backfill data; and generating, at the receiver, a view including the backfill data, the non-backfill data, and the generated at least one of the notification or the graphically distinct indicator.
Dexcom, Inc.

Device and detecting blood group antigens by means of an incomplete antibody

The invention relates to a device for determining a cellular-bound analyte in a liquid sample, comprising a separation matrix with at least one indicator zone. The invention is characterized in that the indicator zone comprises a first antibody directed against the cellular-bound analyte or a fragment thereof and a binding element directed against the first antibody, the first antibody being an incomplete antibody.
Grifols Diagnostic Solutions Inc

Circulating kim-1 levels for detection of pathologies associated with injury to, or cancer of, the kidney

The present invention is directed to kim-1 polypeptide as a plasma acute and chronic kidney injury and renal cell carcinoma biomarker, and methods and kits comprising the use of agents specific to kim-1 for facilitating and enhancing the diagnosis of kidney injury or carcinoma. The present invention is based on the discovery that measuring kim-1 levels in the blood is more accurate and reliable than measuring kim-1 levels in the urine for the diagnosis of subjects with proximal kidney tubule injury or kidney cancer.
The Brigham And Women's Hospital, Inc.

Optical thromboelastography systems and methods

Hand-held optical thromboelastographic sensor and method of using the same for simultaneous assessment of multiple parameters of blood coagulation at a point-of-care. The sensor includes an optical system registering laser speckle intensities associated with portions of a blood sample delivered through a fluid switch to analysis chambers of a cartridge of the sensor, and data-processing circuitry programmed to derive the multiple parameters from speckle intensity.
The General Hospital Corporation

Ppar modulators

The present application relates to amorfrutin analogs and uses as ppar modulators for the treatment of metabolic syndrome, obesity, hyperlipidemia, elevated fasting blood glucose, elevated blood pressure, low hdl cholesterol, type 2 diabetes, cardiovascular disease, a neurodegenerative disease, malaria or irritable bowel syndrome.. .
FundaÇao Universidade De BrasÍlia

Transvascular nerve stimulation apparatus and methods

Electrode structures for transvascular nerve stimulation combine electrodes with an electrically-insulating backing layer. The backing layer increases the electrical impedance of electrical paths through blood in a lumen of a blood vessel and consequently increases the flow of electrical current through surrounding tissues.
Simon Fraser University

Rapid delivery and/or receiving of fluids

The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from beneath the skin. In one aspect, the present invention is generally directed to devices and methods for receiving or extracting blood from a subject, e.g., from the skin and/or from beneath the skin, using devices containing a fluid transporter (for example, one or more microneedles), and a storage chamber having an internal pressure less than atmospheric pressure prior to receiving blood.
Seventh Sense Biosystems, Inc,

Clinical and/or consumer techniques and devices

The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject.
Seventh Sense Biosystems, Inc.





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