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 Optimizing messages sent to diabetic patients in an interactive system based on estimated hba1c levels patent thumbnailOptimizing messages sent to diabetic patients in an interactive system based on estimated hba1c levels
Disclosed is a system of education, monitoring and advising on glucose testing, diet, exercise and drug administration using a device which is carried by the patient and which is capable of: blood glucose testing, displaying messages advising the patient to initiate blood glucose testing, and of recording the results of the test; of displaying advice or further queries based on analysis of the results, and displaying messages relating to advice, education and/or further queries based on the analysis. The messages are optimized based on their effectiveness in bringing about a favorable response in the patient's blood glucose level, estimated hba1c level, or based on other clinical endpoints..
Livongo Heatlh, Inc.


 Insulin management patent thumbnailInsulin management
A method of managing insulin includes receiving blood glucose measurements on a computing device from a glucometer. The blood glucose measurements are separated by a time interval.
Aseko, Inc.


 Devices and methods for analyzing a blood coagulation property patent thumbnailDevices and methods for analyzing a blood coagulation property
A device (10) and method for analyzing blood coagulation in a blood sample. The device (10) includes a housing (12) having an analytical membrane (14) partially enclosed in a housing.
University Of Cincinnati


 Blood analyzer, blood analyzing method, and non-transitory computer-readable storage medium patent thumbnailBlood analyzer, blood analyzing method, and non-transitory computer-readable storage medium
Disclosed is a blood analyzer including a specimen preparation unit that prepares a measurement specimen by mixing a hemolytic agent that hemolyzes red blood cells, a staining dye that dyes nucleic acids, and a blood specimen; a detector that detects intensity of side scattered light and intensity of fluorescence generated with application of light from the measurement specimen prepared by the specimen preparation unit; and an analysis unit that discriminates white blood cells from giant platelets based on the intensity of side scattered light and the intensity of fluorescence detected by the detector, and counts the white blood cells.. .
Sysmex Corporation


 Analyte measurement method and system patent thumbnailAnalyte measurement method and system
Described and illustrated herein are systems and exemplary methods of operating an analyte measurement system having a meter and a test strip. In one embodiment, the method may be achieved by applying a first test voltage between a reference electrode and a second working electrode and applying a second test voltage between the reference electrode and a first working electrode; measuring a first test current, a second test current, a third test current and a fourth test current at the second working electrode after a blood sample containing an analyte is applied to the test strip; measuring a fifth test current at the first working electrode; estimating a hematocrit-corrected analyte concentration from the first, second, third, fourth and fifth test currents; and annunciating the hematocrit-corrected analyte concentration..
Lifescan Scotland Limited


 Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples patent thumbnailCompositions and methods for detecting and quantifying nucleic acid sequences in blood samples
The invention is directed to compositions and methods for rapidly detecting, amplifying, and quantitating one or more pathogen-specific nucleic acids in a biological sample, and in particular, samples obtained from patients with sepsis. The invention also provides diagnostic kits containing specific amplification primers, and labeled detection probes that specifically bind to the amplification products obtained therefrom.
Longhorn Vaccines And Diagnostics, Llc


 Diagnostic for sepsis patent thumbnailDiagnostic for sepsis
A method of diagnosing severe sepsis prior to definitive clinical diagnosis. A pattern of gene expression that correlates strongly with a future diagnosis of severe sepsis and organ failure was identified in patients who had their blood drawn at first clinical presentation.

 Recombinant adeno-associated vectors for targeted treatment patent thumbnailRecombinant adeno-associated vectors for targeted treatment
Novel adeno-associated virus (aav) vectors in nucleotide and amino acid forms and uses thereof are provided. The isolates show specific tropism for certain target tissues, such as blood stem cells, liver, heart and joint tissue, and may be used to transduce stem cells for introduction of genes of interest into the target tissues.
City Of Hope


 Method for preparing human plasma proteins patent thumbnailMethod for preparing human plasma proteins
The invention relates to a method for preparing plasma protein concentrate from blood plasma by means of multicolumn chromatography.. .
Laboratoire Francais Du Fractionnement Et Des Biotechnologies


 Nucleic acid sample preparation patent thumbnailNucleic acid sample preparation
The present invention includes methods, devices and systems for isolating a nucleic acid from a fluid comprising cells. In various aspects, the methods, devices and systems may allow for a rapid procedure that requires a minimal amount of material and/or results in high purity nucleic acid isolated from complex fluids such as blood or environmental samples..
Biological Dynamics, Inc.


Use of modified vasoactive intestinal peptides in the treatment of hypertension

The present invention is based on the discovery that a vip having a binding preference for vpac2 can provide long-acting blood pressure control synergistically with concomitant anti-hypertensive therapies. Accordingly, methods and compositions useful for the treatment and/or amelioration of hypertension are provided..
Phasebio Pharmaceuticals, Inc.

Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—free-b-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions mediated by the cox-2 and 5-lo pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (cox-2) and 5-lipoxygenase (5-lo) enzymes, and reducing cox-2 mrna production.
Unigen, Inc.

Balloon catheters and delivering stents using such catheters

Apparatus and methods are provided for treating lesions within a blood vessel include a two-layer angioplasty balloon designed for the simultaneous deployment of multiple balloon-expanded stents. The high-compliance (elastic) outer balloon secures stent position.

Apparatus and procedure for trapping embolic debris

A collapsible and deployable filter for blocking debris and passing blood in a blood vessel in a patient's body, the filter including; a framework of a flexible material, constructed to have a radially compressed state, in which the framework is radially compressed by radial deforming forces, and a radially expanded state to obdurate an artery; and a flexible filter material secured to said framework and having pores dimensioned to prevent the passage of debris therethrough while allowing the passage of blood. The filter has, in the radially expanded state of the framework, a generally conical or frustoconical form with a large diameter end, a small diameter end opposite to the large diameter end, and a side surface extending between the ends.

Medical device comprising a hydrophilic curved flexible tip for the treatment of varicose veins

The invention relates to a medical device intended to be inserted into the lumen of a cavity of the human or animal body or in the lumen of a blood vessel. The invention is characterised in that said device comprises a probe (5) suitable for delivering a treatment by the endovenous route, and, at the terminal end thereof, a hooked flexible tip (1), wherein the angle α formed between the extension of the end portion of the probe (5) and the extension of the end portion of the tip (1) is strictly less than +90°, said tip comprising means (3) for delivering a treatment.

Systems and methods for percutaneous intravascular access and guidewire placement

A device for allowing passage of a guidewire from a primary blood vessel to an adjacent secondary blood vessel includes a main body having a primary lumen and a secondary lumen, and a piercing member disposed in the secondary lumen, and configured to be moved distally out of the secondary lumen, and to pierce through tissue while being distally moved. A third lumen located within the piercing member is configured to allow placement of a guidewire from the primary blood vessel to the adjacent secondary blood vessel.
Avenu Medical, Inc.

Clot retrieval device for removing clot from a blood vessel

A clot removal device for removing clot from a body vessel comprises an expandable structure and an elongate member. The expandable structure has a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration.
Neuravi Limited

Biological fluid collection device and biological fluid separation and testing system

A biological fluid collection device that is adapted to receive a blood sample having a cellular portion and a plasma portion is disclosed. After collecting the blood sample, the biological fluid collection device is able to transfer the blood sample to a point-of-care testing device or a biological fluid separation and testing device.
Becton, Dickinson And Company

System and blood pressure measurement, computer program product using the method, and computer-readable recording medium thereof

The present invention provides a system and method for blood pressure measurement, a computer program product using the method, and a computer-readable recording medium thereof. The present invention uses a sensor to measure an electrophysiological signal and establishes a personalized cardiovascular model through a numerical method, and re-establishes the personalized cardiovascular model through an optimization algorithm.
National Chiao Tung University

Method and monitoring patient status

A method and apparatus for monitoring the status of a patient on the basis of a plurality of vital signs measurements such as heart rate, breathing rate, blood pressure, temperature, oxygen saturation etc. At each time point a set of such vital signs measurements is compared to two statistical models, one being a population-based statistical model representing the probability distribution of measurements from a large number of individuals, and the second is a patient-specific statistical model based on measurements from the particular patient being monitored.
Obs Medical Limited

Image processing apparatus, image processing method, and storage medium

An image processing apparatus according to an embodiment includes a processing circuitry. The processing circuitry is configured to obtain images in a time series including images of a blood vessel of a subject and correlation information indicating a correlational relationship between physical indices of the blood vessel and function indices of the blood vessel related to vascular hemodynamics, calculate blood vessel morphology indices in a time series indicating morphology of the blood vessel of the subject, on a basis of the images in the time series, and identify a function index of the blood vessel of the subject, by using a physical index of the blood vessel of the subject obtained from the blood vessel morphology indices, on a basis of the correlation information..
Toshiba Medical Systems Corporation

Insulin management

A method of administering insulin includes receiving blood glucose measurements of a patient at a data processing device from a glucometer. The blood glucose measurements are separated by a time interval.
Aseko, Inc.

Sensor, electronic device, microphone, blood pressure sensor, and touch panel

According to one embodiment, a sensor includes a deformable film portion, a first sensing element and a second sensing element. The first sensing element is fixed to the film portion, and includes a first magnetic layer of a first material, a first opposing magnetic layer, and a first intermediate layer.
Kabushiki Kaisha Toshiba

Pressure sensor, microphone, ultrasonic sensor, blood pressure sensor, and touch panel

A pressure sensor of an embodiment includes a support portion, a transformable membrane part and a sensor portion. The membrane part includes an end portion supported by the support portion, and a first area and a second area.
Kabushiki Kaisha Toshiba

Method and reagent for enrichment of circulating tumor dna

The present invention provides a method and a reagent for enrichment of circulating tumor dna, the method comprising the steps of mixing a water phase and an oil phase and shaking the mixture to prepare an emulsion pcr reaction system, and performing emulsion pcr amplification, wherein the water phase comprises peripheral blood plasma dna as template dna, a forward primer and a reverse primer, dntps, a pcr buffer and a dna polymerase, the peripheral blood plasma dna having adapter sequences connected to both ends thereof, and the forward primer and the reverse primer being complementary to the adapter sequences at the two ends respectively; separating the water phase from the oil phase following the emulsion pcr amplification to obtain a pcr amplification product in the water phase; and capturing circulating tumor dna in the pcr amplification product in the water phase by using a probe sequence that specifically binds to the circulating tumor dna. The method of the present invention is capable of performing single-molecule high-fidelity ultramicro parallel amplification and effectively capturing peripheral blood plasma ctdna to provide adequate amount of ctdna to be used for subsequent sequencing detection..
Haplox Biotechnology(shenzhen) Co., Ltd.

Apelin analogues

The invention relates to a peptide analogue comprising at least residues 2-13 of seq id no: 1 and further comprising at least a substitution or modification at residue 13 of seq id no: 1. The invention also relates to a pharmaceutical composition comprising the peptide analogue of the present invention and methods of treatment of diabetes, stimulating insulin release and moderating blood glucose excursions comprising administering the peptide analogue of the present invention to a patient in need thereof..
University Of Ulster

Annular antenna

Apparatus and methods are described for use with a blood vessel of a subject. An annular antenna is placed inside the blood vessel such that radial expansion of the antenna is limited by a circumference of the blood vessel.
Enopace Biomedical Ltd.

Neuromodulation treating acute heart failure syndromes

The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a swan-ganz catheter positionable within a pulmonary artery, such that the swan-ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy.

Iv anticoagulant treatment systems and methods

An intravenous delivery system may have a plurality of components with interior surfaces that cooperate to define a fluid pathway through which fluid flows into a body of a patient. One or more anticoagulant coatings may reside on one or more of the interior surfaces to restrict blood clot formation in the fluid pathway.
Becton, Dickinson And Company

Treatment of diabetes using g-csf

E. Exposing the patient to a stem cell proliferation agent for a third treatment period; whereby the patient's blood glucose level begins trending lower subsequent to initiation of treatment and continues to trend lower after active treatment has ended..

Lactococcus lactis strains

New lactococcus lactis strains, nrrl b-50571 and nrrl b-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower ldl-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation..
Centro De Investigación En Alimentación Y Desarrollo, A.c. (ciad)

Lactococcus lactis strains

New lactococcus lactis strains, nrrl b-50571 and nrrl b-50572, and a bacterial preparation containing the same, have the ability to produce bioactive peptides that reduce blood pressure, lower ldl-cholesterol (bad cholesterol) and present antioxidant properties for better cardiovascular health. These biologically active peptides may be produced within the food for the production of a food product, such as a functional food, or they may be produced from protein sources and subsequently added to a food as part of the formulation or as part of a food supplement or a pharmaceutical preparation..
Centro De Investigación En Alimentacion Y Desarrollo, A.c. (ciad)

Systems and methods for manipulating medical devices

A method for treating a patient having thrombus includes providing a manipulation device including a housing configured to be supported by the hand of a user and having a distal and proximal end, a drive system disposed within the housing, and configured to rotate a rotation member, an engagement member coupled to the rotation member and configured to be removably coupled to an elongate medical device, an activation member carried by the housing such that it can be operated by at least a portion of the hand of the user when the housing is supported by the hand of the user, the drive system configured to apply motive force to the engagement member, securing an elongate member to the engagement member, introducing at least the distal end of the elongate member into a blood vessel adjacent a thrombus, operating the activation member to cause at least some rotation of the rotation member, which in turn causes at least some rotation of the distal end of the elongate member at or near the thrombus, and aspirating at least some of the thrombus with an aspiration catheter.. .
Vesatek, Llc

Injectable valve and other flow control elements

Flow control elements can be injectably delivered through a needle (e.g., a fine hypodermic needle) or other tube and deployed into a blood vessel, percutaneously or laparoscopically, to effect the directional blood flow within the vessel. The valve (or other blood flow or occlusion control element) is delivered from outside the blood vessel directly to the chosen site within the blood vessel.
Amsel Medical Corporation

Ablation targeting nerves in or near the inferior vena cava and/or abdominal aorta for treatment of hypertension

A method for the treatment of a patient for the purpose of lowering blood pressure and/or treating other medical conditions such as cardiac arrhythmias. A catheter having an ablation element is placed inside the body of a patient and is directed to a targeted location either on in the abdominal aorta where the right or left renal arteries branch from the aorta at or near the superior junction or ostia or on the inside of the inferior vena cava near the junction with the right renal vein or in the left renal vein at a position spatially near where the left renal artery branches from the abdominal aorta.
Biosense Webster (israel), Ltd.

Noninvasive blood sugar measurement device

The noninvasive blood sugar measurement device contains a device body, a sensor, a processing module, and an error reduction module. The sensor is configured on a side of the device body for detecting a glucose level in perspiration.
Goldensunda Technology Co., Ltd.

Pressure sensing guidewires

Medical devices and methods for making and using medical devices are disclosed. An example medical device may include a medical device for measuring blood pressure.
Boston Scientific Scimed, Inc.

Systems and methods for failure detection of endovascular stents

A system including a stent further including a plurality of conductive struts disposed within a non-conductive body. The stent is configured to exclude an aneurysm within a blood vessel of a person.

Blood and biological sample collection device and method

Specially designed collection strips and their processing. By using specially designed collection strips, having a backer and one or more absorbent pads, in conjunction with a unique processing method, the processes of analyzing biological samples such as blood, or the like, may be done efficiency with the elimination of cross contamination risk.
Sedia Biosciences Corporation

Method and/or system for determining blood glucose reference sample times

Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor..
Medtronic Minimed, Inc.

Method and device for continuous blood pressure monitoring and estimation

A method and device is provided for the continuous estimation of the blood pressure using a noninvasive technique. The method involves sensing of the displacement signal generated by the palpation of the radial artery.
Tata Consultancy Services Limited

Implantable vital sign sensor

An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end..
Thomas Jefferson University

Implantable vital sign sensor

An implantable vital sign sensor including a housing including a first portion, the first portion defining a first open end, a second open end opposite the first end, and a lumen there through, the first portion being sized to be implanted substantially entirely within the blood vessel wall of the patient. A sensor module configured to measure a blood vessel blood pressure waveform is included, the sensor module having a proximal portion and a distal portion, the distal portion being insertable within the lumen and the proximal portion extending outward from the first open end..
Thomas Jefferson University

Systems and methods for contactless arterial pressure estimator

Methods, apparatuses, devices and systems for measuring the arterial blood pressure in humans and mammals by estimating the time varying arterial diameter using electromagnetic fields in the microwave spectrum (for example), are disclosed. Embodiments may be suitable for wearable devices, and for use by medical practitioners..
Sensifree Ltd.





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