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Bioactive patents



      
           
This page is updated frequently with new Bioactive-related patent applications. Subscribe to the Bioactive RSS feed to automatically get the update: related Bioactive RSS feeds. RSS updates for this page: Bioactive RSS RSS


Inhalable pharmaceutical compositions

Date/App# patent app List of recent Bioactive-related patents
08/28/14
20140242036
 Process for potentiating the production of lingzhi mushroom (ganoderma lucidum) substances and antifungal activity thereof patent thumbnailnew patent Process for potentiating the production of lingzhi mushroom (ganoderma lucidum) substances and antifungal activity thereof
The instant invention refers to a novel process for potentiating the production of substances with antifungal activity obtained from ganoderma lucidum, using a technological device for the differential, qualitative and quantitative expression of proteins and other bioactive molecules, selected from the group consisting of polysaccharides, triterpenoids, fatty acids and ganoderic acids. The compositions containing said substances showed antifungal activity and mycelium growth and fungi ascospore germination inhibiting activity, amongst them mycosphaerella fijiensis, primary pathogenic agent causing black sigatoka disease in banana and plantain crop fields..
08/28/14
20140242013
 Herbal composition for skin-whitening and anti-skin-aging, method of preparation and the use thereof patent thumbnailnew patent Herbal composition for skin-whitening and anti-skin-aging, method of preparation and the use thereof
This invention provides a chinese medicinal formula comprising atractylodis macrocephalae rhizoma, glycyrrhizae radix et rhizoma, angelicae sinensis radix, paeoniae radix alba and poria for skin care. It further relates to a method for preparing bioactive fraction of this formula and to the applications of the bioactive fraction in skin-whitening and anti-skin-aging..
08/28/14
20140242009
 Bioactive compositions from theacea plants and processes for their production and use patent thumbnailnew patent Bioactive compositions from theacea plants and processes for their production and use
The present invention relates to isolated bioactive compositions containing bioactive fractions derived from theacea plants. The present invention also relates to bioactive topical formulations containing the bioactive compositions.
08/28/14
20140239525
 Inhalable pharmaceutical compositions patent thumbnailnew patent Inhalable pharmaceutical compositions
Inhalable pharmaceutical compositions can include an aqueous dispersion of particles including a hydrophobic bioactive agent (e.g., coqio) suitable for continuous aerosolization. Due to their chemical composition and methods of manufacture, the pharmaceutical compositions exhibit distinctive physicochemical properties that provide advantageous aerosol transmission and output..
08/21/14
20140236310
 Sacroiliac joint immobilization patent thumbnailSacroiliac joint immobilization
Improved tools and procedures relate to the immobilization of the sacroiliac joint for the treatment of pain associated with the joint. Kits comprise, for example, a guide element and an immobilization element of a biocompatible material with a size and shape suitable for placement within the sacroiliac joint.
08/21/14
20140236048
 External autonomic modulation patent thumbnailExternal autonomic modulation
In some embodiments, nerves surrounding arteries or leading to organs are targeted with energy sources to correct or modulate physiologic processes. In some embodiments, different types of energy sources are utilized singly or combined with one another.
08/21/14
20140235799
 Method for preparation of a controlled release system patent thumbnailMethod for preparation of a controlled release system
The present invention relates to a method for the preparation of a controlled release system and especially to a method for entrapment of compounds in polymer carriers for controlled release of active ingredients, preferably bioactive ingredients, such as drugs. This method results in a system for controlled release of active ingredients and especially for controlled drug delivery.
08/21/14
20140235542
 Modular, bioactive peptides for binding native bone and improving bone graft osteoinductivity patent thumbnailModular, bioactive peptides for binding native bone and improving bone graft osteoinductivity
A modular peptide design strategy wherein the modular peptide has two functional units separated by a spacer portion is disclosed. More particularly, the design strategy combines a bone-binding portion and a biomolecule-derived portion.
08/21/14
20140234428
 Topical dermal delivery  compositions using self assembling nanoparticles  with cetylated components patent thumbnailTopical dermal delivery compositions using self assembling nanoparticles with cetylated components
The invention, a transdermal delivery method, relates to penetration-enhancing pharmaceutical compositions comprising a novel, stable mixture of cetylated esters, cetyl or stearyl alcohols, polar solvents and surfactants, which, under appropriate conditions, combine into amphiphilic nanoparticles within a stabilized liquid dispersion for use in delivery of medicinal agents through the skin. The term cetosomes is used to describe these particles in order to differentiate them from other nanoparticles, such as niosomes, cerasomes, polymeric micelles, dendrimers, liposomes, lipoids, solid lipid nanoparticles and other particles.
08/21/14
20140231291
 Combination products including bioactive glass and collagen and kits including the same patent thumbnailCombination products including bioactive glass and collagen and kits including the same
The present invention relates to combination products including bioactive glass and collagen as well as kits comprising the same.. .
08/14/14
20140228933
Methods for modifying vascular vessel walls
This invention relates in one aspect to the treatment of a vascular vessel with a biomaterial. The biomaterial can be a remodelable material that strengthens and/or supports the vessel walls.
08/14/14
20140228867
Implantable devices having swellable grip members
The present disclosure relates to implantable medical devices including swellable tissue gripping elements and methods of forming such devices. The implantable medical device may comprise a biocompatible substrate having a surface comprising at least one swellable grip member.
08/14/14
20140227782
Thermosensitive, bioactive biopolymer and associated method of cell harvesting
The present invention relates to a biopolymer and a cell-harvesting scaffold comprising same, as well as the associated cell-harvesting method that allows said harvesting to be performed in a simple and effective manner by reducing the culture temperature. The present invention also relates to a method for synthesising said biopolymer..
08/14/14
20140227365
Ph buffered bioactive glass, and its preparation process and use
The present invention relates to a ph buffered bioactive glass, and its preparation process and use. The ph buffered bioactive glass comprises sio2, cao, na2o, and p2o5, and further comprises solid acidic particles or a tris buffer solution.
08/14/14
20140227364
Methods of manufacturing bioactive gels from extracellular matrix material
The present invention is directed to methods of manufacturing bioactive gels from ecm material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ecm material can be created by digesting particularized ecm material in an alkaline environment and neutralizing to provide bioactive gels..
08/14/14
20140227362
Methods of manufacturing bioactive gels from extracellular matrix material
The present invention is directed to methods of manufacturing bioactive gels from ecm material, i.e., gels which retain bioactivity, and can serve as scaffolds for preclinical and clinical tissue engineering and regenerative medicine approaches to tissue reconstruction. The manufacturing methods take advantage of a new recognition that bioactive gels from ecm material can be created by digesting particularized ecm material in an alkaline environment and neutralizing to provide bioactive gels..
08/14/14
20140227359
Diketopiperazine salts for drug delivery and related methods
Drug delivery systems have been developed based on the formation of diketopiperazine carboxylate salts and microparticles containing the same. The systems may further comprise a bioactive agent.
08/07/14
20140221922
Absorbable crystalline polyether-ester-urethane-based bioactive luminal liner compositions
Bioactive hydroforming luminal liner compositions are formed of an absorbable crystalline amphiphilic polyether-ester-urethane dissolved in a liquid derivative of a polyether glycol that undergoes transformation into a tissue-adhering, resilient interior cover or liner for the controlled release of its bioactive payload at clinically compromised conduits in humans as in the case of bacteria- and yeast-infected vaginal canals, esophagi, and arteries following angioplasty.. .
08/07/14
20140221569
Decorated macromolecular scaffolds
The present invention relates to a method for preparing decorated macromolecular scaffolds. The method of the invention is useful for the generation of bioactive nanoparticles for use in clinical applications.
08/07/14
20140221426
Selective metabolic approach to increasing oral bioavailability of phenylephrine and other phenolic bioactivities
Presystemic metabolism in intestine of bioactives such as phenylephrine is avoided by administering a subject (human or animal) the bioactive (e.g., phenylephrine) in combination with one or more inhibitors of sulfation (e.g., sulfotransferase enzymes aka sults). This can also be enhanced be co-administering inhibitors of monoamine oxidases aka, maos, and uridine diphosphate glucoronysl transferases, aka ugts.
08/07/14
20140220093
Cationic polymers for antimicrobial applications and delivery of bioactive materials
Wherein w′ is a positive number greater than or equal to 3, i′ is a dendritic polyester core covalently linked to w′ independent peripheral linear cationic polymer chains p′. Each of the chains p′ comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group.
08/07/14
20140219935
Topical bioadhesive formulations
The present invention relates to topical bioadhesive formulations comprising low viscosity, non-liquid crystalline, mixtures of: a) at least one neutral diacyl lipid and/or at least one tocopherol; b) at least one phospholipid; c) at least one biocompatible, oxygen containing, low viscosity organic solvent; wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament..
08/07/14
20140219922
Use of scintillator-based nanoparticles for in vivo control of light-sensitive bioactive molecules
The method for remote, non-invasive in vivo control of the activation of light-sensitive bioactive molecules for the purpose of research or therapy is based on delivering to the required site of the body of nanoparticles along with said light-sensitive bioactive molecules. Nanoparticles' core is made from scintillator material that absorbs x-ray and in response emits visible light; they have biocompatible protective coating and surface targeting agents enabling accumulation at the required site(s) within the body.
07/31/14
20140214173
Dynamic bioactive nanofiber scaffolding
A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material.
07/31/14
20140212469
Surface functional bioactive glass scaffold for bone regeneration
A bioactive glass scaffold treated to modify the surface of the bioactive glass scaffold for regenerating new bone tissue is disclosed. In some embodiments, the bioactive glass scaffold may include pores in a grid-like structure to promote the ingrowth of bone tissue, and the modified surface layer may include a hydroxyapatite-like surface.
07/31/14
20140212468
Preparation method of an implant comprising drug delivery layer and implant composition for living donor transplantation comprising the same
The present invention relates to a preparation method of implant comprising drug delivery layer and implant composition for living donor transplantation comprising the same, and more specifically, a preparation method of implant comprising drug delivery layer comprising preparing chitosan-bioactive glass composite solution; preparing drug-containing complex coating composition by adding drug in the chitosan-bioactive glass composite solution; and preparing drug delivery layer by electrophoresis of the complex coating composition on the surface of implant, and implant composition for living donor transplantation comprising the same. The implant composition according to the present invention is able to deliver the drug, and therefore to prevent inflammation, which may occur after the surgery, as well as to promote recovery depending on the type of drugs contained.
07/31/14
20140212465
Treatment and prevention of dental pathology in humans and non-human animals
The present invention relates to methods and compositions for inhibiting, treating, and preventing dental diseases in human and non-human animals, particularly domesticated companion animals. More particularly, the present invention relates to the unexpected discovery that the combination of micron-sized particulate bioactive glass and a topical bisphosphonate yields a composition that is capable of treating and/or preventing dental problems such as periodontal disease, tooth decay and tooth resorption in animals, particularly small mammals such as cats..
07/31/14
20140212419
Ester-based insulin prodrugs
Prodrug formulations of bioactive polypeptides are provided wherein the bioactive polypeptide has been modified by the linkage of a dipeptide to the bioactive polypeptide through an ester linkage. The prodrugs disclosed herein in some embodiments have extended half lives of at least 1.5 hours (e.g., at least 10 hours), and more typically greater than 20 hours and less than 70 hours, and are converted to the active form at physiological conditions through a non-enzymatic reaction driven by chemical instability..
07/24/14
20140207048
Optimized bio-synchronous bioactive agent delivery system
Optimized bio-synchronous drug delivery begins with establishing a bio-synchronous treatment protocol that incorporates individual temporal and innate biological characteristics into a pharmacological treatment plan. The bio-synchronous treatment protocol is thereafter initiated using bioactive agent delivery device.
07/24/14
20140207047
Transdermal drug delivery system and method
A bioactive agent delivery device having a plurality of reservoirs wherein each reservoir houses a solvent provides a means for separable and segregated delivery of bioactive agent(s) to a patient. The device can include a plurality of absorbent materials wherein each absorbent material is pretreated with a bioactive agent and a delivery mechanism operable to deliver to any of the plurality of absorbent materials a controlled portion of solvent from any of a plurality of reservoirs.
07/24/14
20140206692
Oral formulations of kinase inhibitors
The invention is directed to formulations of bioactive compounds of limited water solubility, inhibitors of focal adhesion kinase (fak) of the 2,4-diaminopyridine class, adapted for oral administration to patients. The formulations are self-emulsifying in the gastrointestinal tract of the patients, providing enhanced absorption and bioavailability of the bioactive compounds as dispersions or emulsions in an oil base.
07/24/14
20140206061
Bioactive carbon nanotube composite functionalized with b-sheet polypeptide block copolymer, and preparation method thereof
The present invention relates to a bioactive carbon nanotube composite functionalized with a β-sheet polypeptide block copolymer by combination self-assembly, which shows excellent water dispersion, and has biological activity so as to be used as stimulus-responsive and adaptable biomaterials or in the manufacture of cnt-based electronic biosensor devices. In addition, the bioactive carbon nanotube composite can be used as a composition for delivery of a biological active material into cells.
07/17/14
20140200678
Biomaterials with microsphere gradients and core and shell microspheres
Methods can prepare tissue engineering scaffolds that include a plurality of biocompatible core/shell microspheres linked together to form a three-dimensional matrix. The matrix can include a plurality of pores for growing cells.
07/17/14
20140200676
Delivery systems containing bioactive materials
A delivery system comprising a covering containing at least a first substance for release to a surgical site is provided. The covering includes an elongated containment portion having at least one compartment, wherein the covering includes an elongated containment having a first end and a second end.
07/17/14
20140199712
Compositions and methods for capture of cellular targets of bioactive agents
The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith..
07/17/14
20140199360
Controlled covalent attachment of bioactive bacteriophage for regulating biofilm development
Medical devices that are resistant to biofilm development and methods of the manufacture of biofilm resistant medical devices are provided. One or more bacteriophages are tethered to the surface of a medical device or a hydrogen-type coating on the surface of the device by covalent bonding while maintaining bacteriophage infective or lytic activity.
07/17/14
20140199269
Chromobacterium bioactive compositions and metabolites
Provided are bioactive compounds and metabolites derived from chromobacterium species culture responsible for controlling pests, compositions containing these compounds, methods for obtaining these compounds and methods of using these compounds and compositions for controlling pests.. .
07/17/14
20140196631
Visual assays for coatings incorporating bioactive enzymes for catalytic functions
Disclosed herein are materials such as a coating, comprising a lipolytic enzyme or organophosphrous compound degrading enzyme. Also disclosed herein are methods of visually detecting enzyme activity in a coating by contacting the coating with a substrate of an enzyme and a visual indicator that changes appearance upon production of a product of enzyme activity on a tack-free coating surface..
07/10/14
20140194701
Gateway platform for biological monitoring and delivery of therapeutic compounds
The invention relates to methods and devices for remote or distributed continuous monitoring of physiologically relevant states. The invention provides for methods to automatically detect deviations or other states in physiological parameters and automatically alert a measured subject, user or other authorized party.
07/10/14
20140194604
Process for the synthesis of ketones from internal alkenes
The present invention is directed to methods for oxidizing internal olefins to ketones. In various embodiments, each method comprising contacting an organic substrate, having an initial internal olefin, with a mixture of (a) a biscationic palladium salt; and (b) an oxidizing agent; dissolved or dispersed in a solvent system to form a reaction mixture, said solvent system comprising at least one c2-6 carbon nitrile and optionally at least one secondary alkyl amide, said method conducted under conditions sufficient to convert at least 50 mol % of the initial internal olefin to a ketone, said ketone positioned on a carbon of the initial internal olefin.
07/10/14
20140194325
Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer
The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith..
07/10/14
20140194307
Recognition of cellular target binding by a bioactive agent using intracellular bioluminescence resonance energy transfer
The present invention provides compositions and methods for detection and analysis of intracellular binding of a bioactive agent to a cellular target. In particular, provided herein are bioactive agents tethered to fluorophores, cellular targets fused to bioluminescent reporters, or portions, components, or subunits of bioluminescent reporters, and methods of detecting and analyzing the interaction of bioactive agents with cellular targets therewith..
07/10/14
20140193499
Bioactive glass composition, its applications and respective preparation methods
The present invention relates to development of bioactive glass/glass-ceramic composition that are able to promote a fast deposition layer of carbonated hydroxyapatite upon immersion in simulated body fluid (sbf) for time periods as short as one hour. Such composition might include fluorides, and a variety of oxides (or their precursor compounds), such as na2o—ag2o—sro—cao—mgo—zno—p2o5—sio2—bi2o3—b2o3—caf2, be prepared by the melt route or by the sol-gel process, with the specific composition and the preparation route selected according to the intended functionalities, which can present controlled biodegradation rate and bactericidal activity.
07/10/14
20140193468
Methods for preparation of neo-cartilage constructs
The invention generally relates to systems (i.e. Constructs) for repairing cartilage and methods for preparing the same that introduce a bioactive agent into a culture medium, suspension, scaffold, solution incorporated into the pores of the scaffold, or combinations thereof.
07/10/14
20140193347
Lipid depot formulations
Wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The preformulations are suitable for generating parenteral, non-parenteral and topical depot compositions for sustained release of active agents.
07/10/14
20140193335
Devices and methods for the treatment of cancer
The invention relates to the treatment of cancer. In particular the invention relates to an internal therapeutic product comprising: (i) an anti-cancer component selected from one or both of: a radionucleotide, a cytotoxic drug; and (ii) a silicon component selected from one or more of: resorbable silicon, biocompatible silicon, bioactive silicon, porous silicon, polycrystalline silicon, amorphous silicon, and bulk crystalline silicon, the internal therapeutic product being for the treatment of cancer..
07/03/14
20140188250
Modifiable medical grafts and related methods and apparatuses
Described are medical graft materials and devices which can be usefully modified with liquid additives such as cell suspensions, bioactive agents, or combinations of these. Also described are methods for making and using these medical graft materials and devices..
07/03/14
20140187614
Amino lipids, their synthesis and uses thereof
The present invention provides new amino lipids and a convenient method for synthesising these compounds. These (cationic) amino lipids have good properties as transfection agents.
07/03/14
20140187487
Affinity-based controlled release system
Prolonged or extended release of bioactive protein is achieved using an affinity-based approach which exploits the specific binding of src homology 3 (sh3) domain with short proline-rich peptides. Specifically, methylcellulose was modified with sh3-binding peptides (mc-peptide) with either a weak affinity or strong affinity for sh3.
07/03/14
20140187486
Peripheral administration of proteins including tgf-beta superfamily members for treatment of systemic disorders and disease
The present invention is directed to methods and compositions for accomplishing systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily via a peripheral mode of administration. According to the invention, an exemplary bioactive agent is bmp-7.
07/03/14
20140187473
Compositions and methods for minimally-invasive systemic delivery of proteins including tgf-beta superfamily members
The present invention is directed to methods and compositions for systemic delivery of minimally-soluble bioactive agents such as, but not limited to, proteins of the tgf-β superfamily. According to the invention, an exemplary bioactive agent is bmp-7.
07/03/14
20140186952
Scaffold-free tissue constructs
A tissue construct comprising includes a self-assembled, scaffold-free, high-density cell aggregate. The cell aggregate includes a plurality of cells and a plurality of biocompatible and degradable nanoparticles and/or microparticles that are incorporated within the cell aggregate.
07/03/14
20140186456
Tripartite bioactive composition providing anti-oxidant and anti-inflammatory effects with immune system and stem cell production enhancement
The inventive tripartite composition is a combination of fucoidan, trans-resveratrol, and bovine colostrum in effective quantities, in the range of from 1:1.5:1.5 to 1:10:10 in weight percent. This composition provides antioxidant protection of cells against free radicals, strengthens the immune system, and enhances cellular function and stem cell population, thereby providing renewal and repair throughout the body.
07/03/14
20140186429
Recombinant protein, pharmaceutical composition containing the same, and method of biosynthesizing
The present invention provides a method of biosynthesizing a recombinant protein containing the biologically active peptide, the pharmaceutical composition containing the recombinant protein as well as the preparation of the recombinant protein. Simply speaking the consecutively multiple copies of the bioactive peptide are replaced in the amino acid sequence of a recombinant protein (so called peptide-protein).
07/03/14
20140186339
Compositions and methods for treating ocular diseases and conditions
The present invention relates to compositions and methods for prevention and treatment of ocular diseases and conditions, particularly glaucoma and ocular hypertension. The compositions and methods of the invention utilize immune-derived moieties that are specifically reactive against the bioactive lipid, sphingosine-1-phosphate, and its variants, which moieties are capable of decreasing the effective concentration of bioactive lipid being targeted.
07/03/14
20140186322
Volatile distillate by-product of mint oil that promotes absorption and/or bioavailability of compounds of bio-medical and nutritional interest
Disclosed is an adjuvant for improving the bioavailability of bioactive compositions. The adjuvant is prepared from a byproduct of mint flavor production.
07/03/14
20140186279
Topical bioadhesive formulations
Wherein at least one bioactive agent is dissolved or dispersed in the low viscosity mixture and wherein the pre-formulation forms, or is capable of forming, at least one liquid crystalline phase structure upon contact with an aqueous fluid. The invention additionally relates to a method of delivery of an active agent comprising administration of a preformulation of the invention, a method of treatment comprising administration of a preformulation of the invention and the use of a preformulation of the invention in a method for the manufacture of a medicament..
07/03/14
20140183090
Bioactive packaging
Provided herein are packaging materials that include a bioactive material, as well as methods of using and methods of making such bioactive packaging material.. .
06/26/14
20140180434
Dynamic bioactive nanofiber scaffolding
A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material.
06/26/14
20140180399
Mesh enclosed tissue constructs
Described is a heart valve leaflet manufactured from a mesh material. The mesh material may have an ability to capture circulatory/stationary/migratory cells of the body to become biologically active.
06/26/14
20140180398
Bioabsorbable medical devices and methods of use thereof
One aspect provides implantable medical devices including a bioabsorbable structure having a surface and having a coating layer on at least a portion of the surface. In certain embodiments, the coating layer includes a releasable bioactive and provides for a controlled absorption of the bioabsorbable structure upon implantation in a human or veterinary patient.
06/26/14
20140180395
Bioactive spiral coil coating
An endovascular spiral coil coating and methods of making and using the same.. .
06/26/14
20140180330
Multi-lumen central access vena cava filter apparatus and method of using same
A combined multi-lumen central access catheter and an embolic filter including ports proximal and distal the filter for fluid infusion and/or pressure sensing and infusion ports in the catheter to permit infusion of bioactive agents, flushing agents and/or contrast agents. The embolic filter may be removably coupled to the multi-lumen catheter for temporary placement and retrieval under recommended indications..
06/26/14
20140179941
Synthesis and surface functionalization of particles
Provided are methods of controlling the shape and surface chemistry of nanoparticles, particularly ferrite nanoparticles. Methods for preparing non-spherical ferrite nanoparticles, including nanocubes, nanobars, nanoplates, and nanoflowers, are described.
06/26/14
20140179902
Technetium- and rhenium-bis(heteroaryl) complexes and methods of use thereof
Complexes of heterocyclic radionuclides are prepared based upon ligands having substituted pyridyl and imidazolyl groups. The ligands are bifunctional, having amino acid residues that may act as a linker to a bioactive molecule, and a tridentate chelator that may complex the radionuclide.
06/26/14
20140179708
Multifunctional bioactive compounds
The invention relates to novel multifunctional bioactive compounds, pharmaceutical compositions comprising these compounds and methods of using these compounds, in particular as therapeutic agents.. .
06/26/14
20140178563
Coated medical device
A coated medical device (10) including a structure (12) adapted for introduction into a passage or vessel of a patient. The structure is formed of preferably a non-porous base material (14) having a bioactive material layer (18) disposed thereon.
06/26/14
20140178453
Devices and methods for the regeneration of bony defects
This invention relates to methods for producing a composite bone graft material that can regenerate bony defects in the body. The invention further relates to methods that allow for the production of bioactive glass particles used in the composite that have been surface treated to allow for the production of a highly porous composite that can hold significant amounts of body fluid or other molecules that will aid in the regenerative process.
06/26/14
20140175330
Delivery methods and composition relating to bioactice polyelectrolyte acids from humified organic materials
Improved methods for the separation and isolation of bioactive polyelectrolytes, such as humic acid, fulvic acid, ulmic acid, and humin, from any one or a combination of naturally occurring or synthetically produced humified organic matter (hom) are described. The methods involve the application of an electromagnetic field to an aqueous slurry of the hom to thereby separate one or more bioactive polyelectrolyte fractions from the remaining of the hom.


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Bioactive topics: Polypeptide, Aqueous Solution, Distributed, Therapeutics, Steoporosis, Intravenous, Osteoporosis, Side Effects, Computer Program, Biopolymer, Sacroiliac Joint, Immobilization, Condensation, Antimicrobial Resistance, Aluminum Phosphate

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