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This page is updated frequently with new Autologous-related patent applications. Subscribe to the Autologous RSS feed to automatically get the update: related Autologous RSS feeds. RSS updates for this page: Autologous RSS RSS


Fetal blood recovery systems and methods

Fetal blood recovery systems and methods

Date/App# patent app List of recent Autologous-related patents
12/18/14
20140369985
 Removal of tumor cells from intraoperative autologous blood salvage patent thumbnailRemoval of tumor cells from intraoperative autologous blood salvage
The invention relates to a method performed ex vivo for removal of tumor cells from intraoperatively collected blood salvage, to antibodies and scaffold proteins which mimic antibodies for use in said ex vivo method, to the use of said ex vivo method for removal of tumor cells from intraoperatively collected blood salvage followed by reintroducing the so obtained purified blood salvage or of concentrates of erythrocytes purified by said method to a patient from whom said intra-operatively collected blood was obtained, as well as to blood salvage or a concentrate of erythrocytes, both obtainable by said method for reinfusion to said patient.. .
12/18/14
20140369955
 Methods for autologous stem cell transplantation patent thumbnailMethods for autologous stem cell transplantation
Materials and methods for obtaining populations of lymphocytes and administering the population of lymphocytes to a subject are disclosed herein. In particular, disclosed herein are materials and methods for obtaining lymphocyte populations that contain at least about 0.5×109 nk cells per kilogram weight of the subject from which the cells are harvested..
12/11/14
20140364833
 Fetal blood recovery systems and methods patent thumbnailFetal blood recovery systems and methods
Methods and devices can be used to harvest fetal blood from a placenta. In some instances, the blood is used in laboratory testing so that no such blood is drawn from an infant for such testing.
12/04/14
20140356952
 Derivation of embryonic stem cells and embryo-derived cells patent thumbnailDerivation of embryonic stem cells and embryo-derived cells
This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes.
12/04/14
20140356318
 Adoptive cell therapy with specific regulatory lymphocytes patent thumbnailAdoptive cell therapy with specific regulatory lymphocytes
The present invention comprises a method of treatment of an autoimmune disease involving a specific tolerance induction (“sti”) event, wherein the method includes: collecting a first sample from the patient prior to the sti event; detecting an sti event or performing a procedure that correlates in time to an sti event; collecting a second sample from the patient after the sti event; preparing lymphocytes from the first and second samples; preparing and sequencing dna or cdna from the prepared lymphocytes; identifying sequences of prevalent t or b cell receptors (“prevalent receptor sequences”) among the lymphocytes of the second sample; selecting a regulatory lymphocyte that carries at least one prevalent receptor sequence, which selected regulatory lymphocyte (i) expresses at least one prevalent receptor sequence or (ii) is generated from an autologous or allogeneic naïve lymphocyte, which naïve lymphocyte is engineered and induced to become a regulatory lymphocyte that expresses at least one prevalent receptor sequence; culturing the selected regulatory lymphocyte, thereby generating daughter cells of said regulatory lymphocyte; and administering the daughter cells to the patient.. .
11/27/14
20140348801
 Treatment of vocal cords with autologous dermal fibroblast formulation patent thumbnailTreatment of vocal cords with autologous dermal fibroblast formulation
Dosage units consist of an autologous cell therapy product composed of fibroblasts grown for each individual to be treated for augmentation or regeneration of vocal cords. The suspension of autologous fibroblasts, grown from a biopsy of each individual's own buccal mucosa or skin using current good manufacturing practices (cgmp) and standard tissue culture procedures, is supplied in vials containing cryopreserved fibroblasts or precursors thereof, having a purity of at least 98% fibroblasts and a viability of at least 85%, for administration of from one to six ml, preferably two ml administered three tunes approximately three to six weeks apart, of cells at a concentration of from 1.0-2.0×107 cells/ml..
11/20/14
20140343662
 Method and device for producing a bioartificial tissue construct patent thumbnailMethod and device for producing a bioartificial tissue construct
The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also he obtained in a relatively short time from autologous materials..
11/20/14
20140341862
 Method for producing a biological tissue construct and use of specifically obtained autologous cells patent thumbnailMethod for producing a biological tissue construct and use of specifically obtained autologous cells
The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (epc) which have not been passaged multiple times and have a content of eoec (early outgrowth endothelial progenitor cells) and loec (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz.
11/20/14
20140341861
 Rapid infusion of autologous bone marrow derived stem cells patent thumbnailRapid infusion of autologous bone marrow derived stem cells
The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
11/13/14
20140336443
 Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use patent thumbnailMethod of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use
This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
11/13/14
20140335055
Regenerative autologous cell therapies and methods of use
The present novel technology relates to an autologous cell therapy that comprises a pre-determined amount of a processed bone marrow cellular matrix with a pre-determined amount of pre-mixture, where the pre-mixture includes quantities of anticoagulant solution, dextrose and phosphate buffered saline, and methods for production. The present novel technology further relates to a method of using the composition to reduce discogenic pain in humans..
10/30/14
20140319081
Systems and methods of manufacturing autologous serum products
Methods, systems and kits for production of autologous blood products are provided. Such methods, systems and kits comprise a blood collection set, a serum dilution set, and an aliquot set.
10/23/14
20140314869
Isolating and therapeutic use of perivascular medicinal cells
Disclosed are perivascular medicinal cells (pvmcs), methods of isolating pvmcs, and a composition comprising pvmcs having medicinal capabilities. Specifically, the disclosure provides a method of isolating pvmcs from an umbilical cord blood vessel or from bone.
10/16/14
20140308745
Bone marrow-derived mesenchymal stem cells as a source of neural progenitors
Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodendroglial and neuronal cell types..
10/09/14
20140302605
Method of obtaining a population of cells
A method of obtaining stromal progenitor cells (spc) from subcutaneous adipose tissue by incubation of a very small volume of the subcutaneous adipose tissue in an enzyme solution produces spc that are usable in medical applications based on autologous spc even on individuals having a body mass index lower than 18.5.. .
10/09/14
20140302052
Combination therapy to enhance nk cell mediated cytotoxicity
The function of natural killer (nk) cells is regulated by inhibitory and activating signals delivered by cell surface receptors, 1-7f9 is a fully human monoclonal antibody (mab) directed against kir2dl1 and k1r2dl2/3 receptors that blocks its interaction with its hla-c ligands breaking nk cell tolerance to autologous tumor ceils. Lεnalidomide has been shown to increase nk cell cytotoxicity in vitro.
10/09/14
20140301987
Structure for tissue regeneration and a production method therefor
The present invention relates to a structure for tissue regeneration and to a production method therefor. The structure for tissue regeneration according to the present invention allows autologous tissue to be used, makes stable transplantation possible and can be produced without additional materials such as biopolymers.
10/09/14
20140301985
Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated.
09/25/14
20140288661
Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal
Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue..
09/25/14
20140287020
Surgical device for skin therapy or testing
A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin.
09/25/14
20140286870
Rapid infusion of autologous bone marrow derived stem cells
The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
09/25/14
20140286869
Rapid infusion of autologous bone marrow derived stem cells
The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
09/18/14
20140274788
Leukemia stem cell markers
The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (aml) comprising (1) measuring the expression level of human leukemic stem cell (lsc) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an lsc-targeting therapeutic agent for aml capable of suppressing the expression of a gene selected from among lsc marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for aml patients, comprising obtaining an lsc-purged sample with at least 1 kind of lsc marker as an index; and a method of preventing or treating aml.. .
09/18/14
20140271587
Treatment of inflammatory respiratory disease using biological solutions
Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (copd) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cbma), optionally combining the protein solution and cbma to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof.
09/18/14
20140271582
Cd123-specific chimeric antigen receptor redirected t cells and methods of their use
A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q substitution; a costimulatory signaling domain; and a t cell receptor (tcr) zeta chain signaling domain.
09/18/14
20140271356
Cpb system with dual function blood reservoir
The venous reservoir is omitted from an extracorporeal blood circuit system by substituting a blood reservoir in parallel with the arterial pump. The reservoir has an inlet connected to the outlet of the pump and an outlet connected to the inlet of the pump.
09/11/14
20140257481
Breast reconstruction device and methods
A novel human breast implant and method for using the same comprising a bioabsorbable implant into which native, autologous vascularized tissue and autologous fat is placed and propagated within a patient's chest as a breast implant.. .
09/04/14
20140249071
Enhanced anabolic cytokine production and delivery system
Techniques and devices for removing (filtering out) unwanted/inhibitory components (for example, products, byproducts and/or cell output such as inhibitory catabolic proteins) from a composition (for example, autologous fluid or serum) containing such unwanted/inhibitory components. The devices include at least one construct designed to contain a composition (for example, autologous fluid or serum) containing inhibitory/unwanted components (products, byproducts and/or output of cells such as inhibitory catabolic proteins).
09/04/14
20140248331
Polyhydroxyalkanoate medical textiles and fibers
Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate.
09/04/14
20140246802
Polyhydroxyalkanoate medical textiles and fibers
Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or nomopolymers of 4-hydroxybutyrate.
08/28/14
20140242125
Muscle tissue regeneration using muscle fiber fragments
The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle.
08/28/14
20140242118
Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy
In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments, the method involves autologous tumor cell vaccination prior to autologous hematopoietic and immune cell transplantation.
08/14/14
20140228812
Method for reducing tumors and transforming cancer cells
This invention is related to a phenol-quinone therapy that shrinks tumors and transforms cancer cells. The therapy include four phases.
08/14/14
20140227339
Regenerative tissue grafts and methods of making same
A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (mpcs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. Mpcs can be harvested from debrided muscle tissue following orthopaedic trauma.
08/07/14
20140220682
Isolation, expansion and use of autologous pluripotent stem cells
The present invention relates to methods of isolating and culturing autologous pluripotent stem (aps) cells. The present invention also provides isolated aps cells, populations of aps cells and cultures of aps cells.
08/07/14
20140219980
Treatment for mitochondrial neurogastrointestinal encephalomyopathy (mngie)
The invention provides a method of treating mitochondrial neurogastrointestinal encephalomyopathy (mngie) in a patient, comprising administering to the patient autologous erythrocytes that contain thymidine phosphorylase and are free of animal proteins other than proteins derived from the patient. The erythrocytes generally contain a low amount of endotoxin..
07/31/14
20140212391
Vaginal laxity therapy utilizing cell-based bulking compositions
The invention provides methods for the treatment of vaginal laxity which include delivering a cell-containing composition to the vagina. The composition can include fat tissue to provide a bulking effect to reduce the size of the vaginal opening.
07/24/14
20140207105
Methods for effectively and rapidly desensitizing allergic patients
Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system.
07/24/14
20140205676
Method of tissue repair using a composite material
A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a young's modulus of at least 10 gpa. A calcium comprising salt is disposed in at least some of the pores.
07/24/14
20140205514
Blood separating vessel for extracting autologous platelets, and apparatus for extracting autologous platelets
Provided is a blood separating vessel for extracting autologous platelets, and an apparatus for extracting autologous platelets. The blood separating vessel for extracting autologous platelets comprises: a main body defining an internal space divided into an upper fluid chamber and a lower fluid chamber; an upper cover disposed to seal an upper portion of the upper fluid chamber; a lower cover disposed to seal a lower portion of the lower fluid chamber, the lower cover being coupled such that an outer peripheral surface of the lower cover is elevatable in a state of being in close contact along an inner peripheral surface of the lower fluid chamber by an external force applied upward; and a fluid collection part dividing the internal space into the upper fluid chamber and the lower fluid chamber and including a fluid passage protruding upward to communicate the upper fluid chamber with the lower fluid chamber..
07/10/14
20140194881
Drill, drill cover, and surgical instrument for collecting autologous bone employing same
A drill and drill cover and autogenous bone collector using the same are provided. The autogenous bone collector comprises s shaft unit connected to a driving device and a cutting unit which revolves and collects bone paticles of a patient.
06/26/14
20140178346
Cellular compositions for tissue engineering
Cell compositions for tissue engineering are provided which contain a population of autologous, minimally passaged dermal fibroblasts in combination with a tissue engineering matrix or scaffold, or material forming a matrix or scaffold. In one embodiment, the population of fibroblasts is genetically engineered to secrete a therapeutic protein in an amount effective to induce tissue growth or tissue repair when the cell composition is transplanted into a subject in need thereof.
06/19/14
20140170176
Treatment method for relapsing-remitting multiple sclerosis
Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded cd4+cd25+foxp3+cd127low t reg cells when the patient is in remission. Also disclosed is a method of inhibiting the activity of autoimmune, autologous cytotoxic t and b cells in a patient suffering from relapsing-remitting multiple sclerosis, comprising administering a therapeutically effective amount of autologous cd4+cd25+foxp3+cd127low t reg cells to the patient..
06/12/14
20140162355
Formulations containing and kit for using adipose-derived stem cells and use thereof
Methods and kits for producing cellular fractions enriched in adipose derived stem cells. Methods are provided where adipose tissue obtained from liposuction is enzymatically treated using a solution containing collagenase and divalent cations prior to the application of traditional methods of stromal-vascular fraction isolation.
05/22/14
20140142718
Flexible tissue matrix and methods for joint repair
A synthetic, flexible tissue matrix and methods for repairing hyaline cartilage defects in a joint using the flexible tissue matrix are described. The flexible tissue matrix includes a high molecular weight polycaprolactone polymer entangled with a polysaccharide such as hyaluronic acid.
05/22/14
20140141047
Selection of platelet rich plasma components via mineral binding
Mineral coated devices and methods for delivering an autologous biological molecule using the mineral coated devices are disclosed. The mineral coated devices allow for the isolation and delivery of a biological molecule obtained from the same subject to avoid the safety concerns of current biological therapies obtained by recombinant methods and purification from animal sources.
05/15/14
20140135925
Breast reconstruction device and methods
A novel human breast implant and method for using the same comprising a bioabsorbable implant into which native, autologous vascularized tissue and autologous fat is placed and propagated within a patient's chest as a breast implant.. .
05/08/14
20140127171
Treatment of chronic post-traumatic encephalopathy
Methods of treating chronic post-traumatic encephalopathy (pte) using regenerative approaches is described. In one embodiment, molecules with capability of stimulating endogenous neural stem cells is provided.
04/24/14
20140114070
Compounds that expand hematopoietic stem cells
The present invention relates to compounds and compositions for expanding the number of cd34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (hscs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense..
04/24/14
20140112894
Autologous cells on a support matrix for tissue repair
The present invention relates to a method for the effective treatment of tissue defects and for tissue regeneration. The method includes seeding autologous cells on a support matrix and implanting the cell-seeded support matrix into a site of transplantation.
04/24/14
20140112891
Autologous human adult pluripotent very small embryonic-like (hvsel) stem cell regeneration of bone and cartilage
The invention provides methods and compositions for the repair or regeneration of osteochondral tissue. The methods and compositions provide an effective amount of isolated differentiable human very small embryonic like stem cells (hvsels) sufficient for regeneration or repair of an osteochondral tissue.
04/17/14
20140107699
Active loaded fixation devices
The present disclosure relates to methods for producing, including intra-operatively obtaining, a fixation device, and fixation devices produced thereby, containing an autologous cell concentrate from a physiological solution, wherein the cell concentrate is isolated without the need for centrifugation.. .
04/10/14
20140101786
Generation of autologous t-cells in mice
The invention provides an animal model and methods of generating large numbers of diverse, functional, naïve t cells in mice using bone marrow cells from adult donors.. .
04/10/14
20140099383
Topical dermal formulations
An autologous topical formulation containing conditioned medium obtained from culture of autologous fibroblasts has been developed. Unlike other topical formulations, it is autologous since it is derived solely from cells obtained by the person who is to use the formulation.
04/10/14
20140099287
Plasma protein concentrate for cell delivery in regenerative applications
The invention is directed to concentrating autologously-derived plasma, using the concentrated plasma fluid to dilute the patient's cells and applying the combination of concentrated fluid with cells at a site of pathology or mixing the combination of concentrated fluid with cells with a particulate material like a bone void filler prior to placing the mixture at a site of pathology.. .
04/03/14
20140093482
Methods and apparatuses for isolating and preparing stem cells
The present invention relates to a method of preparing a population of stem cells for autologous implantation to a subject. The cells are activated by irradiating the cells with one or more wavelengths of yellow and red and/or green light.
03/27/14
20140087469
System and process for genetic and epigenetic treatment
Transplantation of total or partial organs or tissues from one person to another creates severe immunologic problems and does not obtain a genetic rejuvenation, for example, of half the biological age of the donor's selected tissue. The invention permits, without a return to an embryonic stage, to develop an autologous and genetic rejuvenated (agr) tissue that can be grafted without graft rejection in the donor's body.
03/27/14
20140087002
Autologous lymph node transfer in combination with vegf-c or vegf-d growth factor therapy to treat lymphedema and to improve reconstructive surgery
Materials and methods are provided to improve survival of lymph nodes and integration of lymph nodes into a lymphatic network, following lymph node transplantation. The treatment or prevention of lymphedema is also addressed.
03/13/14
20140071787
Method and apparatus to create autologous clotting serum
A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall.
03/06/14
20140065629
Methods of treating diseases
In one example, the present invention comprises deliberate tumor insult and sequencing of the t cell repertoire before and after the insult in order to detect and sequence the tcr alpha and beta loci of highly expanded t cell clonotypes. In some examples, this information is used in turn to create autologous genetically engineered t cells with tcr sequences that target the individual's tumor..
03/06/14
20140065098
Method to augment immune system in response to disease or injury
In one example, the present invention comprises a deliberate insult or the recognition that an insult has occurred in a patient, which insult induces an immune recognition event. The t cell repertoire is catalogued from samples of the patient's lymphocytes from before and after the insult in order to detect and sequence the tcr alpha and beta loci of highly expanded t cell clonotypes.
03/06/14
20140065096
Cancer therapy by ex vivo activated autologous immune cells
Disclosed are therapeutic methods for ex-vivo activation of immune cells from a cancer patient for the purpose of inducing tumor regression and/or suppressing metastasis and/or tumor recurrence. In one embodiment mononuclear cells of a patient are isolated from peripheral blood and activated by a combination of innate immune system activators together with means allowing for t cell activation..
02/27/14
20140056842
Cellular therapeutic approaches to traumatic brain and spinal cord injury
The described invention provides cellular therapeutic approaches for treating a vascular insufficiency following a traumatic injury to head or spine that results in an injury to brain, spinal cord, or both by administering a therapeutic amount of an isolated, nonexpanded population of autologous mononuclear cells comprising a subpopulation of cd34+ cells, which further contains a subpopulation of potent sdf-1 mobile cd34+/cxcr-4 cells that have cxcr-4-mediated chemotactic activity.. .


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Autologous topics: Autologous, Stem Cells, Differentiation, Fibroblast, Cell Therapy, Transplant, Cell Differentiation, Tissue Engineering, Myeloid Leukemia, Gene Expression, Acute Myeloid Leukemia, Complication, Umbilical Cord, Premature Birth, Premature Infant

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This listing is a sample listing of patent applications related to Autologous for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Autologous with additional patents listed. Browse our RSS directory or Search for other possible listings.
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