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Autologous

Autologous-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170261508

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response ...
Cd123-specific chimeric antigen receptor redirected t cells and methods of their use
City Of Hope
September 14, 2017 - N°20170260277

A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q ...
Autologous pleurodesis methods and devices
Carefusion 2200, Inc.
September 14, 2017 - N°20170259038

System and components for inducing pleurodesis or other sclerosis or desired adhesion conditions to treat a patient, while minimizing likelihood of tissue damage from direct application of sclerosis-enhancing materials. A tube device is provided that is configured to elute sclerosis-enhancing material and/or other medicaments including autologous or otherwise patient compatible blood and/or blood component(s) via an assembly ...
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Systems and methods for preparing protein enhanced serums
Arthrex, Inc.
September 14, 2017 - N°20170258849

A system for preparing a serum includes a containment device, a cage positioned inside the containment device, a cap attachable to the containment device and configured to cover the cage, an inlet port configured to introduce an autologous fluid into the containment device, and an outlet port configured to remove a serum from the containment device.
Methods and compositions for treating ovarian failure
Augusta University Research Institute, Inc.
September 14, 2017 - N°20170258842

Methods and compositions for treating ovarian failure are provided. In one embodiment, the method includes administering stem cells into the ovary of a female subject in need of such treatment. The stem cells are preferably bone marrow derived stem cells (bmsc). In other embodiments, the stem cells are embryonic stem cells, adult stem cells, induced stem cells, induced pluripotent stem ...
Percutaneous aspirating cannula
Adimend Biosciences, Llc
September 14, 2017 - N°20170258459

The dual syringe with percutaneous cannula is a medical device for harvesting and transferring cells for autologous transplantation without the requirement of a surgical setting or ambulatory care. The dual syringe is a closed sterile system that allows for the harvesting syringe to harvest the cells/tissue from a first location of a patient which is then centrifuged to aggregate ...
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Systems, compositions, and methods for transplantation and treating conditions
Cytonics Corporation
August 31, 2017 - N°20170246372

Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (a2m) from whole blood and or recombinant a2m are provided. Also provided are methods of treating wounds with a2m. Methods for utilizing a2m in combination with other treatments (e. G., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or ...
Compositions and methods for treating b cell mediated autoimmune disorders
Opexa Therapeutics, Inc.
August 31, 2017 - N°20170246272

Provided herein are methods, kits, compositions and uses related to the treatment of a b cell mediated autoimmune disorder with a t cell vaccine comprising a therapeutically effective amount of t cells autologous to the patient and that react to an autoantigen or specific epitope(s) thereof associated with the b cell mediated autoimmune disorder, wherein the treatment is provided ...
Derivation of embryonic stem cells and embryo-derived cells
Astellas Institute For Regenerative Medicine
August 24, 2017 - N°20170240857

This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell ...
Autologous hiv-1 proteins for the treatment of latent hiv-1 infection
Case Western Reserve University
August 24, 2017 - N°20170239325

A method of reducing a latent hiv-specific memory-cd4+ t cell pool in a subject includes the steps of: preparing at least one hiv-1 protein coding sequence from a sample obtained from the subject, wherein the sample includes hiv-1 rna; introducing the at least one hiv-1 protein coding sequence into at least one expression construct using yeast homologous recombination; transfecting a ...
Compounds that expand hematopoietic stem cells
Novartis Ag
August 24, 2017 - N°20170239296

The present invention relates to compounds and compositions for expanding the number of cd34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (hscs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages ...
3d tissue-engineered bone marrow for personalized therapy and drug development
Washington University
August 17, 2017 - N°20170232146

A tissue-engineered bone marrow for personalized therapy of a patient is described. The tissue-engineered bone marrow includes an autologous fibrin scaffold and a plurality of patient-derived cells isolated from the patient's bone marrow. The autologous fibrin scaffold is made using fibrinogen isolated from the patient's bone marrow. The plurality of patient-derived cells may include cells associated with a hematological or ...
Multi-indication mrna cancer immunotherapy
Morphogenesis, Inc.
August 17, 2017 - N°20170232090

Synthetic bacterial messenger rna can be used to prepare autologous, allogenic or direct nucleic acid cancer vaccines. Cancer cells are transfected either in vitro or in vivo with mrna obtained from dna that encodes an immunogenic bacterial protein. An immune response to the cancer is generated from direct administration of the mrna in vivo or administration of vaccines prepared from ...
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Methods of isolating t cells having antigenic specificity for a cancer-specific mutation
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
August 10, 2017 - N°20170224800

Disclosed are methods of isolating t cells having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous apcs of the patient to ...
Dual syringe with percutaneous cannula
Adimend Biosciences, Llc
August 10, 2017 - N°20170224318

The dual syringe with percutaneous cannula is a medical device for harvesting and transferring cells for autologous transplantation without the requirement of a surgical setting or ambulatory care. The dual syringe is a closed sterile system that allows for the harvesting syringe to harvest the cells/tissue from a first location of a patient which is then centrifuged to aggregate ...
Methods of isolating t cell receptors having antigenic specificity for a cancer-specific mutation
The United State Of America, As Represented By The Secretary, Department Of Health And Human Service
August 03, 2017 - N°20170218042

Disclosed are methods of isolating a tcr having antigenic specificity for a mutated amino acid sequence encoded by a cancer-specific mutation, the method comprising: identifying one or more genes in the nucleic acid of a cancer cell of a patient, each gene containing a cancer-specific mutation that encodes a mutated amino acid sequence; inducing autologous apcs of the patient to ...
Methods for effectively and rapidly desensitizing allergic patients
Perosphere Inc.
July 27, 2017 - N°20170209567

Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system. In preferred embodiments, the compositions are administered to yield therapeutically effective levels of antigen within the lymph, where macrophages reside in the greatest ...
Derivation of embryonic stem cells
Astellas Institute For Regenerative Medicine
July 20, 2017 - N°20170204368

This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e. G., in conjunction with reproductive ...
Bioactive protein, use thereof and method for its production
Koppert B.v.
July 20, 2017 - N°20170204147

The present invention according to a firrst aspect relates to a trichoderma longibrachiatum strain comprising an autologous nucleotide sequence coding for a protein having at least 70% sequence similarity with the amino acid sequence of seq id no: 1 and its use for the treatment of a plant. Further aspects of the invention relate to a protein derived from said strain, methods ...
Personalized cancer vaccines and methods therefor
Washington University
July 20, 2017 - N°20170202939

Methods of cane r treatment based, on personalized vaccines are disclosed. Individual amino acid substitutions from tumors are revealed using whole genome sequencing, and identified as neoantigens silico. Peptide sequences are then tested in vitro for ability to bind hla molecules and to be presented to cd8+ t-cells. A vaccine is formed using neoantigen peptides and an adjuvant or dendritic ...
Method for producing autologous tolerogenic dendritic cells (toldcs) with specific antigens and their use in ...
Pontificia Universidad Catolica De Chile
July 13, 2017 - N°20170196950

The invention relates to a method for producing tolerogenic dendritic cells (toldcs) with specific antigens, comprising the steps of: (a) culturing precursors of dendritic cells in an animal-serum-free medium, using cytokines, il-4 and gm-csf, in order to differentiate same in dendritic cells; (b) producing apoptotic cells; (c) culturing the dendritic cells obtained in step (b) in the presence of compounds ...
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