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Autologous

Autologous-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Systems and methods for autologous biological therapeutics
Greyledge Technologies, Llc
April 12, 2018 - N°20180100133

An autologous cell concentrating system and method are disclosed. The system has a blood separation component, a first vessel, a second vessel, a first valve, a second valve, and a concentration and flow logic and control component. The concentration and flow logic and control component is configured to: determine a first volume of a target cell-poor fraction in the first ...
Composition and methods of genome editing of b-cells
Dana-farber Cancer Institute, Inc.
April 05, 2018 - N°20180094243

The present invention provides methods compositions and methods of preparing autologous b-cells that secrete a monoclonal of interest useful in immunotherapy.
Multifunctional composite skin or wound dressing as regenerative skin substitute
March 29, 2018 - N°20180085486

With its unique composite network structure of micro-cavities and microfilaments, a material can mimic the skin barrier function: capable of shielding contamination, moisture absorption, moisture retention, breathability, pliability and adhesion. It is capable of absorbing wound exudates to facilitate rapid, non-invasive autolytic debridement and bi-directional regulation to ensure sufficient drainage, but also targetedly and compartmentally retaining exudates in the dressing ...
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Cell maintainer for autologous cell therapy production
Thrive Bioscience, Inc.
March 22, 2018 - N°20180079999

In some aspects, the invention relates to automated cell culture incubators and their methods of use. In one aspect, the disclosure provides cell culture incubators having an airlock chamber, a storage chamber and/or an internal chamber. In some aspects, the disclosure provides methods for producing autologous mammalian cell cultures.
Furin-knockdown and gm-csf-augmented (fang) cancer vaccine
Gradalis, Inc.
March 15, 2018 - N°20180073038

Compositions and methods for cancer treatment are disclosed herein. More specifically, the present invention describes an autologous cancer vaccine genetically modified for furin knockdown and gm-csf expression. The vaccine described herein attenuates the immunosuppressive activity of tgf-β through the use of bi-functional shrnas to knock down the expression of furin in cancer cells, and to augment tumor antigen ...
Autologous cell multidimensional molding apparatus
3d Global Biotech Inc.
March 15, 2018 - N°20180072973

The present invention discloses an autologous cell multidimensional molding apparatus, which can customize an artificial implant by using an autologous cell. The autologous cell multidimensional molding apparatus comprises a barotropic room, an autologous cell culturing module, a supplying module, a multi-axis molding module, and an implant saving module. The autologous cell culturing module cultivates the autologous cells and sends the ...
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Methods to accelerate wound healing in diabetic subjects
Joslin Diabetes Center, Inc.
March 08, 2018 - N°20180066327

Methods of accelerating wound healing in diabetic subjects using autologous cell grafts treated to specifically inhibit protein kinase c delta (pkc6), as well as cells and compositions for use in these methods. Provided herein are methods for preparing cells for application to a wound in a diabetic subject. The methods include incubating the cells in the presence of an effective ...
Methods for isolating and proliferating autologous cancer antigen-specific cd8+ t cells
National Cancer Center
March 01, 2018 - N°20180057793

Provided is a method for isolating and proliferating autologous cancer antigen-specific cd8+t cells, and more particularly, a method for selecting an epitope recognized by cd8+ t cells from autologous cancer antigens present in blood of individual cancer patients; and isolating autologous cancer antigen-specific cd8+ t cells by using a peptide of the selected epitope, and a method of massively ...
Autologous somatic cell therapy, method of controllable preparation of therapeutic composition and procedure of adaptive ...
Progena Inc.
March 01, 2018 - N°20180057792

A blood product containing peripheral blood mononuclear cells (pbmcs) in an amount of at least 4 million cells per milliliter and human chorionic gonadotropin (hcg in an amount of at least 150 international units (iu) per milliliter. A method of preparing the blood product, including applying hcg to a female patient, then obtaining pbmcs from the female patient, then adding hcg to ...
Ex vivo liquid biopsy
Helomics Corporation
February 22, 2018 - N°20180052168

Embodiments disclosed herein provide in vitro methods for use in the culture and biochemical analysis of normal or malignant cells in autologous, allogeneic, and xenogeneic fluids and the biomarkers secreted from those cells over time and in response to various changing conditions. The methods disclosed herein provide a clinical diagnostic and research platform that provides for the study of fundamental ...
Surgical wound healing composition and method of applying the same
February 22, 2018 - N°20180050066

Compositions and methods are disclosed for improving the healing of surgical wounds, and specifically for improving the survival rate, color retention rate, density, and scarring rate of a hair follicular graft following a hair transplantation surgery. The composition may be a suspension for injection proximal to the surgical graft recipient site, with the suspension comprising 0. 4-0. 5 ml of a suspension ...
Systems and methods to reduce injury in the heart
Cardiac Pacemakers, Inc.
February 15, 2018 - N°20180043071

This document discusses, among other things, systems and methods to reduce ischemic or metabolic injury to a patient's heart. A system to reduce ischemic or metabolic injury to a patient's heart may include a pulse generator for generating electrical pulses or shock, a pacing lead with at least one pacing electrode configured to deliver electrical pulses received from the pulse ...
Human cord blood as a source of neural tissue repair of the brain and spinal ...
Saneron Ccel Therapeutics, Inc.
February 15, 2018 - N°20180042968

The present invention relates to the use of umbilical cord blood cells from a donor or patient to provide neural cells which may be used in transplantation. The isolated cells according to the present invention may be used to effect autologous and allogeneic transplantation and repair of neural tissue, in particular, tissue of the brain and spinal cord and to ...
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Method for harvesting and transplanting cells
Adimend Biosciences, Llc
February 15, 2018 - N°20180042589

The dual syringe with percutaneous cannula is a medical device for harvesting and transferring cells for autologous transplantation without the requirement of a surgical setting or ambulatory care. The dual syringe is a closed sterile system that allows for the harvesting syringe to harvest the cells/tissue from a first location of a patient which is then centrifuged to aggregate ...
Methods and compositions based on diphtheria toxin-interleukin-3 conjugates
Scott & White Memorial Hospital
January 25, 2018 - N°20180022788

The present invention provides methods for inhibiting interleukin-3 receptor-expressing cells, and, in particular, inhibiting the growth of such cells by using a diphtheria toxin-human interleukin-3 conjugate (dt-il3) that is toxic to cells expressing the interleukin-3 receptor. In preferred embodiments, the dt-il3 conjugate is a fusion protein comprising amino acids 1-388 of diphtheria toxin fused via a peptide linker to full-length, ...
System for generating high concentration factors for low cell density suspensions
Flodesign Sonics, Inc.
January 18, 2018 - N°20180016570

Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as t ...
Bone repairing material and method for producing thereof
3d Global Biotech Inc.
January 18, 2018 - N°20180015206

A bone repairing material comprises a composition including an α-calcium sulfate hemihydrate and an autologous bone powder, wherein the bone repairing material contains 20˜60 weight percent of the autologous bone powder and 40˜80 weight percent of the α-calcium sulfate hemihydrate. The bone repairing material has a particle size in the range of 50˜1,000 &#...
Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal
Zimmer Trabecular Metal Technology, Inc.
January 11, 2018 - N°20180008747

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant ...
Autologous tumor vaccines and methods
Vaccinogen, Inc.
January 11, 2018 - N°20180008686

Autologous anti-cancer vaccines and methods of manufacture and treatment are provided, including expansion of individual patient-derived tumor cells in an immune-compromised animal(s) to attain, quantitatively and qualitatively, sufficient material for efficacious vaccine production and utilization, to elicit an immune response against micrometastases and/or recurrence in the individual patient following tumor excision.
Vaginal laxity therapy utilizing cell-based bulking compositions
Ams Research Corporation
January 11, 2018 - N°20180008647

The invention provides methods for the treatment of vaginal laxity which include delivering a cell-containing composition to the vagina. The composition can include fat tissue to provide a bulking effect to reduce the size of the vaginal opening. The cells can provide healing and revascularization of the vaginal treatment area to sustain the bulking provided by the fat. The invention ...
Methods for isolation of platelets
Anthrogenesis Corporation
December 28, 2017 - N°20170369845

Provided herein are methods for the isolation of platelets, for example, isolation of platelets from umbilical cord blood. In certain embodiments, presented herein are methods for preparation of platelet rich plasma. In one aspect, provided herein are methods for isolation of platelets from blood. In certain embodiments, presented herein are methods for isolation of platelets from cord blood, e. G., ...
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