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Autologous patents



      
           
This page is updated frequently with new Autologous-related patent applications. Subscribe to the Autologous RSS feed to automatically get the update: related Autologous RSS feeds. RSS updates for this page: Autologous RSS RSS


Compounds and methods for kinase modulation, and indications therefor

Plexxikon

Compounds and methods for kinase modulation, and indications therefor

Compounds and methods for kinase modulation, and indications therefor

Biocardia

Treatment for chronic myocardial infarct

Date/App# patent app List of recent Autologous-related patents
07/02/15
20150183793
 Compounds and methods for kinase modulation, and indications therefor patent thumbnailnew patent Compounds and methods for kinase modulation, and indications therefor
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of fms, kit, flt3, trka, trkb and trkc kinase protein.
06/25/15
20150174221
 Systems, compositions, and methods for transplantation patent thumbnailSystems, compositions, and methods for transplantation
Systems and methods for purification and concentration of autologous alpha-2-macroglobulin (a2m) from whole blood are provided. Also provided are diagnostic methods for identifying sites in the synovial joints, spine, tendons or ligaments for treatment of pain, degeneration, or inflammation with autologous a2m.
Cytonics Corporation
06/18/15
20150166547
 Compounds and methods for kinase modulation, and indications therefor patent thumbnailCompounds and methods for kinase modulation, and indications therefor
Compounds and salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof and uses thereof are described. In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on at least one of fms protein kinase or kit protein kinase.
Plexxikon Inc.
06/18/15
20150164786
 Treatment for chronic myocardial infarct patent thumbnailTreatment for chronic myocardial infarct
A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (abm) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (mi) patients. The treatment is safe and improves ejection fraction (ef)..
Biocardia, Inc.
06/18/15
20150164486
 Method and  restoring articular cartilage patent thumbnailMethod and restoring articular cartilage
The present invention comprises the provision and use of new and improved arthroscopic instrumentation for (i) harvesting a tissue biopsy from a non-critical section of a joint, and (ii) sizing and seating an autologous graft at an implant site.. .
Prochon Biotech Ltd.
06/11/15
20150157781
 Fluid concentrator, autologous concentrated body fluids, and uses thereof patent thumbnailFluid concentrator, autologous concentrated body fluids, and uses thereof
The present invention provides devices and methods for concentrating a fluid and for treating a patient with the concentrated fluid. The concentrator apparatus includes a main housing (12) defining a separation chamber (14), a filter housing (48) containing a filter (46) comprising a filter element, a piping (44) for moving concentrated fluid from the separation chamber to the filter, and ports (32) for pressurizing the concentrated fluid past the filter element of the filter.
Circle Biologics, Llc
05/28/15
20150148912
 Improved absorbable patch, in reinforced pga, for the replacement of a portion of bladder wall following partial cystectomy patent thumbnailImproved absorbable patch, in reinforced pga, for the replacement of a portion of bladder wall following partial cystectomy
A patch (1) for the replacement of a portion of bladder wall, following partial cystectomy, comprises a textile (2) derived from a pga yarn and provided with a star-shaped support frame, flexible and harmonic, formed by a plurality of radial strips (3) manufactured by injection of a pga/pla copolymer, the patch (1) being suitable for making autologous fibrous capsule cells, generated by the process of tissue reconstruction, grow thereon after its insertion inside the patient.. .
05/28/15
20150148901
 Apparatus and  breast reconstruction and augmentation using an autologous platelet-rich fibrin matrix patent thumbnailApparatus and breast reconstruction and augmentation using an autologous platelet-rich fibrin matrix
Described herein are systems and methods for soft tissue reconstruction and augmentation using a platelet-rich fibrin matrix. In one embodiment the system of the present invention includes a blood collection apparatus capable of drawing blood from a patient, a matrix preparation container configured to hold a patient's blood while the blood is separated and coagulated to form a platelet-rich fibrin matrix therein, and a matrix delivery device configured to receive the matrix preparation container therein and compress and force the platelet-rich fibrin matrix out of the matrix preparation container and into the patient.
05/21/15
20150140035
 Autologous biological cancer vaccine patent thumbnailAutologous biological cancer vaccine
The present disclosure relates to an autologous biological cancer vaccine and to a method for preparing the same. The vaccine of the present application is a biological vaccine obtained from overexpressed proteins in the serum of cancer patients, proteins to which have been added immunological adjuvants such as an attenuated virus dna and amino acids in order to cause an immune response, blocking tumor cells.
Universidad Manuela Beltran
05/14/15
20150132267
 Fibroblast mixtures and methods of making and using the same patent thumbnailFibroblast mixtures and methods of making and using the same
The present disclosure provides a non-autologous product that is a mixture of two or more cells or tissue cultures of fibroblast, or extracts from cultures, or media cultures, isolated from separate individuals, either homogeneous or heterogeneous. The cells or factors are blended together in a product that imparts desired characteristics to the skin of a recipient who is not a source of the mixture.
04/30/15
20150118199

Methods of measuring potential for therapeutic potency and defining dosages for autologous cell therapies


autologous bone marrow cells (bmc) are transplanted to a heterologous site in a patient after a sample of the patient's bmc has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (bmc) from the patient for the phenotypic profile, such as a cd profile, the phenotype profile may be assessed to determine the likelihood that the bmc will be suitable for transplantation to the heterologous tissue site without enriching particular phenotypic population(s) of the bmc..
Biocardia, Inc.
04/30/15
20150118198

Bone marrow-derived mesenchymal stem cells as a source of neural progenitors


Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodengroglial and neuronal cell types..
Multiple Sclerosis Research Center Of New York
04/23/15
20150110751

Stem cells as an individualized maternal therapy for prevention of prematurity


The present invention relates to the field of premature birth. More specifically, the present invention provides methods and compositions useful for preventing premature birth.
Kennedy Krieger Institute, Inc.
04/23/15
20150110750

Methods for using autologous fibroblasts to alter skin identity


The present invention relates to the field of autologous fibroblasts. More specifically, the present invention provides methods and compositions comprising autologous fibroblasts and uses thereof to alter skin identity.
The Government Of The United States Of America, As Represented By The Secretary Of The Army
04/09/15
20150098924

Method for ex-vivo purging in autologous transplantation


The present invention concerns a new method for ex-vivo purging of cells in autologous transplantation, wherein the sample of taken cells is treated with a sufficient amount of a multimeric form of the soluble portion of fasl to kill malignant cells without substantially affecting viability of cells to be transplanted. Autologous stem cell transplantation (asct) following high-dose chemotherapy with or without radiotherapy has become the standard therapy for the majority of patients with large-cell lymphomas, multiple myeloma, and refractory/recidivating hodgkin's disease.
Topotarget Switzerland Sa
04/02/15
20150094532

Visualization devices, systems, and methods for informing intravascular procedures on blood vessel valves


The present technology relates generally to devices and methods for intravascular evaluation of blood vessels. Many embodiments of the technology relate to the intravascular evaluation of blood vessels before, during and after creation of autologous valves.
Intervene, Inc.
04/02/15
20150093416

Autologous tumor vaccines and methods


autologous anti-cancer vaccines and methods of manufacture and treatment are provided, including expansion of individual patient-derived tumor cells in an immune-compromised animal(s) to attain, quantitatively and qualitatively, sufficient material for efficacious vaccine production and utilization, to elicit an immune response against micrometastases and/or recurrence in the individual patient following tumor excision.. .
Vaccinogen, Inc.
03/19/15
20150079194

Systems, compositions, and methods for transplantation and treating conditions


Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (a2m) from whole blood and or recombinant a2m are provided. Also provided are methods of treating wounds with a2m.
Cytonics Corporation
03/12/15
20150073444

Polyhydroxyalkanoate medical textiles and fibers


Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate.
Tepha, Inc.
03/05/15
20150064145

Bone marrow-derived mesenchymal stem cells as a source of neural progenitors


Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodengroglial and neuronal cell types..
Multiple Sclerosis Research Center Of New York
03/05/15
20150060363

Device and processing and producing autologous platelet-rich plasma


A system and method are provided, including an integrated single-use kit, for processing whole blood to produce platelet rich plasma. A two stage spinning membrane separator, has a first stage for receiving whole blood and separating substantially all red blood cells from plasma and platelets, and a second stage for further separating platelet rich plasma from plasma.
Fenwal Inc.
02/26/15
20150057751

Acellular dermal graft


An acellular dermal graft is provided. The acellular dermal graft may be useful in minimizing side effects caused after transplantation since an environment favorable for formation of new blood vessels and proliferation of autologous tissues is provided by forming a multi-penetration structure in an acellular dermal tissue, removing a basement membrane layer and/or subjecting corners to slope cutting, and transplantation is stably performed within a short transplantation time due to improved extensibility and flexibility of tissues.
L&c Bio Co., Ltd.
02/12/15
20150045907

Absorbable cap for bladder enlargement in patients with low compliance or for the replacement of a vast portion of bladder following bilharzia


A description is given of a domed cap (100) for the enlargement of an atrophied bladder (200), in biocompatible and absorbable material including a textile (1) made with yarns or with monofilaments deriving from pga fibres, characterised in that the textile (1) is supported by a star-shaped frame with domed profile, formed by a plurality of radial strips (3) manufactured by injection of a pga/pla copolymer, the cap (100) being suitable for growing thereon autologous fibrous capsule cells, generated by the process of tissue reconstruction, after its insertion inside the patient.. .
02/05/15
20150037387

Biomatrix composition and methods of biomatrix seeding


Apparatus and methods are described for generating autologous tissue grafts, the apparatus including a point of care svf isolation unit that includes a tissue digestion chamber in fluid communication with a lipid separating chamber, whereby svf cells are isolated without centrifugation; and a cell seeding chamber in fluid communication with the svf isolation unit, said cell seeding chamber adapted to support a cell scaffold. Methods and materials for cell seeding, including through the provision of micro rough scaffold surfaces, are also provided..
Ingeneron, Inc.
02/05/15
20150037347

Method of treating a pathological syndrome and a pharmaceutical agent


Pharmaceutical agent for treating a pathological syndrome contains activated form of ultra-low doses of monoclonal, polyclonal or natural antibodies to an antigen, wherein said activated form is prepared by means of repeated consecutive dilution and external treatment, predominantly based on homeopathic technology, and said antigen is a substance or a drug acting as a direct cause of the pathological syndrome or involved in regulation of mechanisms of its formation. At that, activated forms of ultra-low doses of antibodies are raised against antigens of exogenous or endogenous origin, against autologous antigens, fetal antigens; anti-idiotypic antibodies are used too..
02/05/15
20150037303

Cells, compositions, and treatment methods for stimulation of hematopoiesis


The invention discloses novel methods, compositions of matter, and kits for the treatment of disorders affecting the hematopoietic system. Patients are administered an autologous cellular mixture derived from adipose stromal vascular fraction, said cellular mixture comprising endothelial cells, endothelial progenitor cells, t regulatory cells, monocytes, and hematopoietic stem cells.
Regen Biopharma, Inc
01/29/15
20150030657

Smooth muscle cell constructs


The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.. .
Tengion, Inc.
01/29/15
20150030578

Method for producing activated autologous platelet rich and platelet poor plasma and methods of use


A method and kit to produce activated autologous platelet rich and platelet poor plasma (aaprpp) and methods of use to treat pain. The method to produce aaprpp generally comprising (1) obtaining whole blood from patient; (2) centrifuging whole blood in a collection tube; (3) extracting platelet rich and platelet poor plasma mixture from collection tube; and (4) transferring platelet rich and platelet poor plasma mixture to an activation tube containing at least one platelet aggregator and at least one platelet activator to obtain a resulting platelet concentration.
01/22/15
20150025311

Small single-port arthroscopic lavage, directed tissue drying, biocompatible tissue scaffold and autologous regenerated cell placement delivery system


A system for performing arthroscopic lavage, directed tissue drying, and the accurate placement of a biocompatible tissue scaffold for the adherence of autologous regenerated cells through a small single port of entry into a joint compartment. The system is comprised of a handpiece having valves for irrigation and suctioning and a dual valve swivel cannula attached to the handpiece.
01/22/15
20150025223

System and producing interleukin receptor antagonist (ira)


The present invention relates to a system and method for producing high levels of autologous il-1ra cytokine, comprising: a blood collection vessel (1), a cover (4), a portion of separation gel (2), an anticoagulant portion (3), a plasma collection syringe comprising a sharp needle (9), a buffy coat collection syringe (11) and an incubation tube with cover (15). The vessel is adapted such that, when containing the whole blood (5), and centrifuged after treatment, yields separation fractions comprising, a first fraction of rbcs sediment (6), a second fraction of said gel (2), a third fraction comprising wbcs, platelets and), and fourth fraction of plasma solution (8)..
Estar Technologies Ltd
01/15/15
20150017723

Process of expanding t cells


The present disclosure relates to a novel process for expanding t cells, such as autologous t cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients.. .
Baylor College Of Medicine
01/15/15
20150017220

Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair


A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the present invention do not require long-term incubation or cultivation in vitro prior to use in in vivo applications.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
01/01/15
20150004245

Composition for promoting increase in subcutaneous tissue and subcutaneous adipose tissue


In particular, a composition for breast augmentation that includes a composition promoting an increase in subcutaneous tissue, wherein the promoting composition aims at accumulating and increasing adipose tissue under the skin of a breast by generating and increasing the adipose tissue around a mammary gland and enables recovery of autologous tissue and recovery of appearance by a safe and natural process, and a method for breast augmentation are provided. A composition promoting an increase in subcutaneous tissue that contains autologous plasma and a basic fibroblast growth factor (b-fgf), in particular, a composition for breast augmentation is provided.
12/25/14
20140379083

Tubular bioengineered smooth muscle structures


Methods of generating tubular, bioengineered, smooth muscle structures are disclosed as well as bioengineered tissue for tubular organ repair or replacement. The methods can include the steps of obtaining smooth muscle cells; culturing the muscle cells to form a smooth muscle cell construct of directionally oriented smooth muscle cells; disposing the smooth muscle cell construct around a tubular scaffold; and culturing construct and scaffold in a growth media until a smooth muscle cell structure is achieved.
Wake Forest University Health Sciences
12/25/14
20140377865

Derivation of embryonic stem cells


This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as ivf..
Advanced Cell Technology, Inc.
12/18/14
20140369985

Removal of tumor cells from intraoperative autologous blood salvage


The invention relates to a method performed ex vivo for removal of tumor cells from intraoperatively collected blood salvage, to antibodies and scaffold proteins which mimic antibodies for use in said ex vivo method, to the use of said ex vivo method for removal of tumor cells from intraoperatively collected blood salvage followed by reintroducing the so obtained purified blood salvage or of concentrates of erythrocytes purified by said method to a patient from whom said intra-operatively collected blood was obtained, as well as to blood salvage or a concentrate of erythrocytes, both obtainable by said method for reinfusion to said patient.. .
Trion Pharma Gmbh
12/18/14
20140369955

Methods for autologous stem cell transplantation


Materials and methods for obtaining populations of lymphocytes and administering the population of lymphocytes to a subject are disclosed herein. In particular, disclosed herein are materials and methods for obtaining lymphocyte populations that contain at least about 0.5×109 nk cells per kilogram weight of the subject from which the cells are harvested..
Mayo Foundation For Medical Education And Research
12/11/14
20140364833

Fetal blood recovery systems and methods


Methods and devices can be used to harvest fetal blood from a placenta. In some instances, the blood is used in laboratory testing so that no such blood is drawn from an infant for such testing.
12/04/14
20140356952

Derivation of embryonic stem cells and embryo-derived cells


This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes.
12/04/14
20140356318

Adoptive cell therapy with specific regulatory lymphocytes


The present invention comprises a method of treatment of an autoimmune disease involving a specific tolerance induction (“sti”) event, wherein the method includes: collecting a first sample from the patient prior to the sti event; detecting an sti event or performing a procedure that correlates in time to an sti event; collecting a second sample from the patient after the sti event; preparing lymphocytes from the first and second samples; preparing and sequencing dna or cdna from the prepared lymphocytes; identifying sequences of prevalent t or b cell receptors (“prevalent receptor sequences”) among the lymphocytes of the second sample; selecting a regulatory lymphocyte that carries at least one prevalent receptor sequence, which selected regulatory lymphocyte (i) expresses at least one prevalent receptor sequence or (ii) is generated from an autologous or allogeneic naïve lymphocyte, which naïve lymphocyte is engineered and induced to become a regulatory lymphocyte that expresses at least one prevalent receptor sequence; culturing the selected regulatory lymphocyte, thereby generating daughter cells of said regulatory lymphocyte; and administering the daughter cells to the patient.. .
11/27/14
20140348801

Treatment of vocal cords with autologous dermal fibroblast formulation


Dosage units consist of an autologous cell therapy product composed of fibroblasts grown for each individual to be treated for augmentation or regeneration of vocal cords. The suspension of autologous fibroblasts, grown from a biopsy of each individual's own buccal mucosa or skin using current good manufacturing practices (cgmp) and standard tissue culture procedures, is supplied in vials containing cryopreserved fibroblasts or precursors thereof, having a purity of at least 98% fibroblasts and a viability of at least 85%, for administration of from one to six ml, preferably two ml administered three tunes approximately three to six weeks apart, of cells at a concentration of from 1.0-2.0×107 cells/ml..
11/20/14
20140343662

Method and device for producing a bioartificial tissue construct


The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also he obtained in a relatively short time from autologous materials..
11/20/14
20140341862

Method for producing a biological tissue construct and use of specifically obtained autologous cells


The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (epc) which have not been passaged multiple times and have a content of eoec (early outgrowth endothelial progenitor cells) and loec (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz.
11/20/14
20140341861

Rapid infusion of autologous bone marrow derived stem cells


The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
11/13/14
20140336443

Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use


This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
11/13/14
20140335055

Regenerative autologous cell therapies and methods of use


The present novel technology relates to an autologous cell therapy that comprises a pre-determined amount of a processed bone marrow cellular matrix with a pre-determined amount of pre-mixture, where the pre-mixture includes quantities of anticoagulant solution, dextrose and phosphate buffered saline, and methods for production. The present novel technology further relates to a method of using the composition to reduce discogenic pain in humans..
10/30/14
20140319081

Systems and methods of manufacturing autologous serum products


Methods, systems and kits for production of autologous blood products are provided. Such methods, systems and kits comprise a blood collection set, a serum dilution set, and an aliquot set.
10/23/14
20140314869

Isolating and therapeutic use of perivascular medicinal cells


Disclosed are perivascular medicinal cells (pvmcs), methods of isolating pvmcs, and a composition comprising pvmcs having medicinal capabilities. Specifically, the disclosure provides a method of isolating pvmcs from an umbilical cord blood vessel or from bone.
10/16/14
20140308745

Bone marrow-derived mesenchymal stem cells as a source of neural progenitors


Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodendroglial and neuronal cell types..
10/09/14
20140302605

Method of obtaining a population of cells


A method of obtaining stromal progenitor cells (spc) from subcutaneous adipose tissue by incubation of a very small volume of the subcutaneous adipose tissue in an enzyme solution produces spc that are usable in medical applications based on autologous spc even on individuals having a body mass index lower than 18.5.. .
10/09/14
20140302052

Combination therapy to enhance nk cell mediated cytotoxicity


The function of natural killer (nk) cells is regulated by inhibitory and activating signals delivered by cell surface receptors, 1-7f9 is a fully human monoclonal antibody (mab) directed against kir2dl1 and k1r2dl2/3 receptors that blocks its interaction with its hla-c ligands breaking nk cell tolerance to autologous tumor ceils. Lεnalidomide has been shown to increase nk cell cytotoxicity in vitro.
10/09/14
20140301987

Structure for tissue regeneration and a production method therefor


The present invention relates to a structure for tissue regeneration and to a production method therefor. The structure for tissue regeneration according to the present invention allows autologous tissue to be used, makes stable transplantation possible and can be produced without additional materials such as biopolymers.
10/09/14
20140301985

Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree


A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated.
09/25/14
20140288661

Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal


Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue..
09/25/14
20140287020

Surgical device for skin therapy or testing


A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin.
09/25/14
20140286870

Rapid infusion of autologous bone marrow derived stem cells


The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
09/25/14
20140286869

Rapid infusion of autologous bone marrow derived stem cells


The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
09/18/14
20140274788

Leukemia stem cell markers


The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (aml) comprising (1) measuring the expression level of human leukemic stem cell (lsc) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an lsc-targeting therapeutic agent for aml capable of suppressing the expression of a gene selected from among lsc marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for aml patients, comprising obtaining an lsc-purged sample with at least 1 kind of lsc marker as an index; and a method of preventing or treating aml.. .
09/18/14
20140271587

Treatment of inflammatory respiratory disease using biological solutions


Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (copd) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cbma), optionally combining the protein solution and cbma to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof.
09/18/14
20140271582

Cd123-specific chimeric antigen receptor redirected t cells and methods of their use


A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q substitution; a costimulatory signaling domain; and a t cell receptor (tcr) zeta chain signaling domain.
09/18/14
20140271356

Cpb system with dual function blood reservoir


The venous reservoir is omitted from an extracorporeal blood circuit system by substituting a blood reservoir in parallel with the arterial pump. The reservoir has an inlet connected to the outlet of the pump and an outlet connected to the inlet of the pump.


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Autologous topics: Autologous, Stem Cells, Differentiation, Fibroblast, Cell Therapy, Transplant, Cell Differentiation, Tissue Engineering, Myeloid Leukemia, Gene Expression, Acute Myeloid Leukemia, Complication, Umbilical Cord, Premature Birth, Premature Infant

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