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Autologous

Autologous-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW System for generating high concentration factors for low cell density suspensions
Flodesign Sonics, Inc.
January 18, 2018 - N°20180016570

Acoustophoretic devices and methods for concentrating targeted biological cells in a reduced volume using multi-dimensional acoustic standing waves are disclosed. The methods include flowing a mixture of a host fluid and the biological cells through an acoustophoretic device. The acoustophoretic devices include an inlet, an outlet, and a flow chamber having an ultrasonic transducer-reflector pair. Biological cells, such as t ...
NEW Bone repairing material and method for producing thereof
3d Global Biotech Inc.
January 18, 2018 - N°20180015206

A bone repairing material comprises a composition including an α-calcium sulfate hemihydrate and an autologous bone powder, wherein the bone repairing material contains 20˜60 weight percent of the autologous bone powder and 40˜80 weight percent of the α-calcium sulfate hemihydrate. The bone repairing material has a particle size in the range of 50˜1,000 &#...
Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal
Zimmer Trabecular Metal Technology, Inc.
January 11, 2018 - N°20180008747

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant ...
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Vaginal laxity therapy utilizing cell-based bulking compositions
Ams Research Corporation
January 11, 2018 - N°20180008647

The invention provides methods for the treatment of vaginal laxity which include delivering a cell-containing composition to the vagina. The composition can include fat tissue to provide a bulking effect to reduce the size of the vaginal opening. The cells can provide healing and revascularization of the vaginal treatment area to sustain the bulking provided by the fat. The invention ...
Methods for isolation of platelets
Anthrogenesis Corporation
December 28, 2017 - N°20170369845

Provided herein are methods for the isolation of platelets, for example, isolation of platelets from umbilical cord blood. In certain embodiments, presented herein are methods for preparation of platelet rich plasma. In one aspect, provided herein are methods for isolation of platelets from blood. In certain embodiments, presented herein are methods for isolation of platelets from cord blood, e. G., ...
Methods of measuring potential for therapeutic potency and defining dosages for autologous cell therapies
Biocardia, Inc.
December 21, 2017 - N°20170363623

Autologous bone marrow cells (bmc) are transplanted to a heterologous site in a patient after a sample of the patient's bmc has been tested and found to have a phenotypic profile which meets minimum criteria for transplantation. The phenotypic profile may be obtained by screening a sample of bone marrow cells (bmc) from the patient for the phenotypic profile, such ...
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Antivenom compositions and uses thereof
Snakepharm Enterprises, Llc
November 30, 2017 - N°20170340679

Disclosed herein are compositions and methods for treating a victim of a venomous snakebite. Antivenom compositions are prepared from snake plasma or from snake eggs. The antivenom compositions are able to neutralize a snake venom from an autologous snake. The antivenom compositions can be administered to a snakebite victim to treat or prevent the pathological effects of a venomous snakebite.
Method of preparing autologous cells and methods of use for therapy
Biocardia, Inc.
November 16, 2017 - N°20170327790

A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium which can be used in a clinical setting, and a business method for performing such expansions in the future as a service for patients. A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium including a diagnostic kit for the ...
Protein-coupled red blood cell compositions and methods of their use
Augusta University Research Institute, Inc.
November 16, 2017 - N°20170326213

Methods and compositions for using n-hydroxysuccinimide and n-hydroxysulfosuccinimide to covalently couple protein(s) to the surface of red blood cells universally, rapidly and conveniently are provided. In one embodiment, the compositions promote immune tolerance in a subject. One embodiment provides autologous or allogenic red blood cells having whole protein(s) of interests conjugated to proteins on or within the plasma ...
Composite polymeric nanofibers for skin regeneration
Augusta University Research Institute, Inc.
November 09, 2017 - N°20170319744

A method for preparing a skin regeneration scaffold is disclosed. The method may include preparing a polymer solution by dissolving a biopolymer in a solvent, and subjecting the polymer solution to a template-assisted extrusion process with a nanoporous material as a template in order to produce polymer nanofibers. Furthermore, the method includes fabricating a multilayer composite nanofibrous scaffold using the ...
Artificial antigen-presenting cells and methods for producing and using the same
Indiana University Research And Technology Corporation
October 26, 2017 - N°20170304462

Described herein are biomimetic janus particles useful as artificial antigen presenting cells capable of activating t cells in vitro. “bull's eye” ligand patterns mimicking either the native or reverse organization of the t cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating t cells in vitro using biomimetic janus ...
Method and composition for producing enhanced anti-inflammatory/ anti-catabolic and regenerative agents from autologous physiological fluid
Indiana University Research And Technology Corporation
October 19, 2017 - N°20170296583

Described are methods of producing an autologous composition useful for treatment of damaged and/or injured connective tissues, chronic tendinosis, chronic muscle tears and/or chronic degenerative joint conditions and skin inflammatory disorders in a mammal. The method comprises preparing an anti-inflammatory/anti-catabolic component of the autologous composition comprising il-1ra and timps. An anti-inflammatory/anti-catabolic component is prepared comprising: ...
Method and apparatus for restoring articular cartilage
Indiana University Research And Technology Corporation
October 19, 2017 - N°20170296156

The present invention comprises the provision and use of new and improved arthroscopic instrumentation for (i) harvesting a tissue biopsy from a non-critical section of a joint, and (ii) sizing and seating an autologous graft at an implant site.
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Predicting allergic reactions
Alcyomics Ltd
October 05, 2017 - N°20170285001

This present invention provides a method of predicting immunogenicity and hypersensitivity or allergic reactions to chemical compounds, therapeutics, cosmetics and other chemical compositions. The method uses an in vitro assay employing autologous blood derived cells and an autologous cultured skin biopsy and is of particular utility in the identification and prediction of skin sensitizers that cause allergic contact dermatitis.
Compounds and methods for kinase modulation, and indications therefor
Alcyomics Ltd
October 05, 2017 - N°20170283423

In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of fms, kit, flt3, trka, trkb and trkc kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of fms, ...
Method for preparing a biological tissue construct and use of autologous cells obtained specifically
Medizinische Hochschule Hannover (mhh)
September 28, 2017 - N°20170274021

The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (epc) which have not been passaged multiple times and have a content of eoec (early outgrowth endothelial progenitor cells) and loec (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz. Myoblasts, myofibroblasts, smooth muscle cells or the progenitors thereof, are, in ...
Glycolipid containing compositions for use in the treatment of tumours
Agalimmune Limited (gb/gb)
September 21, 2017 - N°20170266214

The invention relates to pharmaceutical compositions comprising α-gal boel for use in treating patients with tumors. The invention also relates to methods of treating tumours using said compositions. The invention discloses that following intratumoral injection of α-gal boel, binding of the natural anti-gal antibody to de novo expressed tumoural α-gal epitopes induces inflammation resulting ...
Treatment for chronic myocardial infarct
Biocardia, Inc.
September 21, 2017 - N°20170266107

A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (abm) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (mi) patients. The treatment is safe and improves ejection fraction (ef).
Method for digital archiving and manufacturing of dental prosthetics and prosthesis, and teaching and training ...
Eped Inc.
September 21, 2017 - N°20170265972

A method for digital archiving and manufacturing of dental prosthetics and a prosthesis, and teaching and training for same are provided. The method mainly includes the following steps: preoperative scanning: creating a first digital model file; optical positioning and turning treatment: creating a second digital model file from a turning process; physical model calculation: creating reversely an autologous crown model ...
Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170261508

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response ...
Cd123-specific chimeric antigen receptor redirected t cells and methods of their use
City Of Hope
September 14, 2017 - N°20170260277

A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q ...
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