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Autologous patents



      
           
This page is updated frequently with new Autologous-related patent applications. Subscribe to the Autologous RSS feed to automatically get the update: related Autologous RSS feeds. RSS updates for this page: Autologous RSS RSS


Date/App# patent app List of recent Autologous-related patents
01/29/15
20150030657
 Smooth muscle cell constructs patent thumbnailnew patent Smooth muscle cell constructs
The present invention relates to the regeneration, reconstruction, augmentation or replacement of luminal organs or tissue structures in a subject in need using scaffolds seeded with autologous or non-autologous cell populations that are or are not derived from the corresponding organ or tissue structure that is the subject of the regeneration, reconstruction, augmentation or replacement.. .
Tengion, Inc.
01/29/15
20150030578
 Method for producing activated autologous platelet rich and platelet poor plasma and methods of use patent thumbnailnew patent Method for producing activated autologous platelet rich and platelet poor plasma and methods of use
A method and kit to produce activated autologous platelet rich and platelet poor plasma (aaprpp) and methods of use to treat pain. The method to produce aaprpp generally comprising (1) obtaining whole blood from patient; (2) centrifuging whole blood in a collection tube; (3) extracting platelet rich and platelet poor plasma mixture from collection tube; and (4) transferring platelet rich and platelet poor plasma mixture to an activation tube containing at least one platelet aggregator and at least one platelet activator to obtain a resulting platelet concentration.
01/22/15
20150025311
 Small single-port arthroscopic lavage, directed tissue drying, biocompatible tissue scaffold and autologous regenerated cell placement delivery system patent thumbnailSmall single-port arthroscopic lavage, directed tissue drying, biocompatible tissue scaffold and autologous regenerated cell placement delivery system
A system for performing arthroscopic lavage, directed tissue drying, and the accurate placement of a biocompatible tissue scaffold for the adherence of autologous regenerated cells through a small single port of entry into a joint compartment. The system is comprised of a handpiece having valves for irrigation and suctioning and a dual valve swivel cannula attached to the handpiece.
01/22/15
20150025223
 System and  producing interleukin receptor antagonist (ira) patent thumbnailSystem and producing interleukin receptor antagonist (ira)
The present invention relates to a system and method for producing high levels of autologous il-1ra cytokine, comprising: a blood collection vessel (1), a cover (4), a portion of separation gel (2), an anticoagulant portion (3), a plasma collection syringe comprising a sharp needle (9), a buffy coat collection syringe (11) and an incubation tube with cover (15). The vessel is adapted such that, when containing the whole blood (5), and centrifuged after treatment, yields separation fractions comprising, a first fraction of rbcs sediment (6), a second fraction of said gel (2), a third fraction comprising wbcs, platelets and), and fourth fraction of plasma solution (8)..
Estar Technologies Ltd
01/15/15
20150017723
 Process of expanding t cells patent thumbnailProcess of expanding t cells
The present disclosure relates to a novel process for expanding t cells, such as autologous t cells, cell populations therefrom, pharmaceutical compositions comprising the said cell populations and use of the cells and compositions for treatment, particular the treatment or prophylaxis of virus infection and/or cancer, for example in immune compromised or immune competent human patients.. .
Baylor College Of Medicine
01/15/15
20150017220
 Rapid preparation of stem cell matrices for use in tissue and organ treatment and repair patent thumbnailRapid preparation of stem cell matrices for use in tissue and organ treatment and repair
A rapid method for preparing stem cell and physiologically acceptable matrix compositions for use in tissue and organ repair is described. Compared with previous tissue engineering materials, the stem cell-matrix compositions of the present invention do not require long-term incubation or cultivation in vitro prior to use in in vivo applications.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
01/01/15
20150004245
 Composition for promoting increase in subcutaneous tissue and subcutaneous adipose tissue patent thumbnailComposition for promoting increase in subcutaneous tissue and subcutaneous adipose tissue
In particular, a composition for breast augmentation that includes a composition promoting an increase in subcutaneous tissue, wherein the promoting composition aims at accumulating and increasing adipose tissue under the skin of a breast by generating and increasing the adipose tissue around a mammary gland and enables recovery of autologous tissue and recovery of appearance by a safe and natural process, and a method for breast augmentation are provided. A composition promoting an increase in subcutaneous tissue that contains autologous plasma and a basic fibroblast growth factor (b-fgf), in particular, a composition for breast augmentation is provided.
12/25/14
20140379083
 Tubular bioengineered smooth muscle structures patent thumbnailTubular bioengineered smooth muscle structures
Methods of generating tubular, bioengineered, smooth muscle structures are disclosed as well as bioengineered tissue for tubular organ repair or replacement. The methods can include the steps of obtaining smooth muscle cells; culturing the muscle cells to form a smooth muscle cell construct of directionally oriented smooth muscle cells; disposing the smooth muscle cell construct around a tubular scaffold; and culturing construct and scaffold in a growth media until a smooth muscle cell structure is achieved.
Wake Forest University Health Sciences
12/25/14
20140377865
 Derivation of embryonic stem cells patent thumbnailDerivation of embryonic stem cells
This present invention provides novel methods for deriving embryonic stem cells, those cells and cell lines, and the use of the cells for therapeutic and research purposes without the destruction of the embryo. It also relates to novel methods of establishing and storing an autologous stem cell line prior to implantation of an embryo, e.g., in conjunction with reproductive therapies such as ivf..
Advanced Cell Technology, Inc.
12/18/14
20140369985
 Removal of tumor cells from intraoperative autologous blood salvage patent thumbnailRemoval of tumor cells from intraoperative autologous blood salvage
The invention relates to a method performed ex vivo for removal of tumor cells from intraoperatively collected blood salvage, to antibodies and scaffold proteins which mimic antibodies for use in said ex vivo method, to the use of said ex vivo method for removal of tumor cells from intraoperatively collected blood salvage followed by reintroducing the so obtained purified blood salvage or of concentrates of erythrocytes purified by said method to a patient from whom said intra-operatively collected blood was obtained, as well as to blood salvage or a concentrate of erythrocytes, both obtainable by said method for reinfusion to said patient.. .
Trion Pharma Gmbh
12/18/14
20140369955

Methods for autologous stem cell transplantation


Materials and methods for obtaining populations of lymphocytes and administering the population of lymphocytes to a subject are disclosed herein. In particular, disclosed herein are materials and methods for obtaining lymphocyte populations that contain at least about 0.5×109 nk cells per kilogram weight of the subject from which the cells are harvested..
Mayo Foundation For Medical Education And Research
12/11/14
20140364833

Fetal blood recovery systems and methods


Methods and devices can be used to harvest fetal blood from a placenta. In some instances, the blood is used in laboratory testing so that no such blood is drawn from an infant for such testing.
12/04/14
20140356952

Derivation of embryonic stem cells and embryo-derived cells


This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes.
12/04/14
20140356318

Adoptive cell therapy with specific regulatory lymphocytes


The present invention comprises a method of treatment of an autoimmune disease involving a specific tolerance induction (“sti”) event, wherein the method includes: collecting a first sample from the patient prior to the sti event; detecting an sti event or performing a procedure that correlates in time to an sti event; collecting a second sample from the patient after the sti event; preparing lymphocytes from the first and second samples; preparing and sequencing dna or cdna from the prepared lymphocytes; identifying sequences of prevalent t or b cell receptors (“prevalent receptor sequences”) among the lymphocytes of the second sample; selecting a regulatory lymphocyte that carries at least one prevalent receptor sequence, which selected regulatory lymphocyte (i) expresses at least one prevalent receptor sequence or (ii) is generated from an autologous or allogeneic naïve lymphocyte, which naïve lymphocyte is engineered and induced to become a regulatory lymphocyte that expresses at least one prevalent receptor sequence; culturing the selected regulatory lymphocyte, thereby generating daughter cells of said regulatory lymphocyte; and administering the daughter cells to the patient.. .
11/27/14
20140348801

Treatment of vocal cords with autologous dermal fibroblast formulation


Dosage units consist of an autologous cell therapy product composed of fibroblasts grown for each individual to be treated for augmentation or regeneration of vocal cords. The suspension of autologous fibroblasts, grown from a biopsy of each individual's own buccal mucosa or skin using current good manufacturing practices (cgmp) and standard tissue culture procedures, is supplied in vials containing cryopreserved fibroblasts or precursors thereof, having a purity of at least 98% fibroblasts and a viability of at least 85%, for administration of from one to six ml, preferably two ml administered three tunes approximately three to six weeks apart, of cells at a concentration of from 1.0-2.0×107 cells/ml..
11/20/14
20140343662

Method and device for producing a bioartificial tissue construct


The tissue construct with viable cells in an extracellular matrix made of fibrin is produced with a special method, in which a matrix material and cells are shaped into a hollow body, in particular a tubular hollow body, by means of a rotational casting method in a hollow mould (1), the method comprising the following steps: (a) introduction of cells of at least one cell type and/or a fibrinogen preparation into the rotating hollow mould (1) with the aid of an applicator (4), said applicator (4) being displaced along the rotational axis during the introduction and step (a) being performed one or more times; (b) continuation of the rotation process until the fibrinogen solidifies into a dimensionally stable matrix, obtaining a primarily solidified tissue construct; (c) removal of the tissue construct from the mould. The construct can also he obtained in a relatively short time from autologous materials..
11/20/14
20140341862

Method for producing a biological tissue construct and use of specifically obtained autologous cells


The method for preparing a tissue construct for medical purposes uses endothelial progenitor cells (epc) which have not been passaged multiple times and have a content of eoec (early outgrowth endothelial progenitor cells) and loec (late outgrowth endothelial progenitor cells). These cells and fibroblasts and/or muscle cells, viz.
11/20/14
20140341861

Rapid infusion of autologous bone marrow derived stem cells


The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
11/13/14
20140336443

Method of repairing age and disease immune dysfunction and cellular senescence with lymphoid stem cells and then re-applying those for therapeutic use


This invention relates to methods for treatment of diseases of ageing including immunosenescence, immune dysfunction, inflammation and impairment of early lymphoid lineage differentiation. The invention more specifically relates to the use of granulocyte colony stimulating factors to assist in stem cell mobilization, optionally in combination with the application of a method of delivering precise magnetic field patterns which agree with the body's own natural magnetic field patterns, and further in combination with re-infusion of previously collected autologous cells and/or plasma, optionally including allogeneic (healthy donor) cells and blood plasma..
11/13/14
20140335055

Regenerative autologous cell therapies and methods of use


The present novel technology relates to an autologous cell therapy that comprises a pre-determined amount of a processed bone marrow cellular matrix with a pre-determined amount of pre-mixture, where the pre-mixture includes quantities of anticoagulant solution, dextrose and phosphate buffered saline, and methods for production. The present novel technology further relates to a method of using the composition to reduce discogenic pain in humans..
10/30/14
20140319081

Systems and methods of manufacturing autologous serum products


Methods, systems and kits for production of autologous blood products are provided. Such methods, systems and kits comprise a blood collection set, a serum dilution set, and an aliquot set.
10/23/14
20140314869

Isolating and therapeutic use of perivascular medicinal cells


Disclosed are perivascular medicinal cells (pvmcs), methods of isolating pvmcs, and a composition comprising pvmcs having medicinal capabilities. Specifically, the disclosure provides a method of isolating pvmcs from an umbilical cord blood vessel or from bone.
10/16/14
20140308745

Bone marrow-derived mesenchymal stem cells as a source of neural progenitors


Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodendroglial and neuronal cell types..
10/09/14
20140302605

Method of obtaining a population of cells


A method of obtaining stromal progenitor cells (spc) from subcutaneous adipose tissue by incubation of a very small volume of the subcutaneous adipose tissue in an enzyme solution produces spc that are usable in medical applications based on autologous spc even on individuals having a body mass index lower than 18.5.. .
10/09/14
20140302052

Combination therapy to enhance nk cell mediated cytotoxicity


The function of natural killer (nk) cells is regulated by inhibitory and activating signals delivered by cell surface receptors, 1-7f9 is a fully human monoclonal antibody (mab) directed against kir2dl1 and k1r2dl2/3 receptors that blocks its interaction with its hla-c ligands breaking nk cell tolerance to autologous tumor ceils. Lεnalidomide has been shown to increase nk cell cytotoxicity in vitro.
10/09/14
20140301987

Structure for tissue regeneration and a production method therefor


The present invention relates to a structure for tissue regeneration and to a production method therefor. The structure for tissue regeneration according to the present invention allows autologous tissue to be used, makes stable transplantation possible and can be produced without additional materials such as biopolymers.
10/09/14
20140301985

Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree


A method of repairing diseased or dysfunctional pancreas or liver is provided. The method involves preparation of a suspension of stem cells and/or progenitor cells such as biliary tree stem cells, hepatic stem cells, pancreatic stem cells or their descendants, committed progenitor cells, from healthy tissue of the patient or of the biliary tree of a non-autologous donor and engrafting the cells into the wall of bile ducts near to the organ to be treated.
09/25/14
20140288661

Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal


Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue..
09/25/14
20140287020

Surgical device for skin therapy or testing


A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin.
09/25/14
20140286870

Rapid infusion of autologous bone marrow derived stem cells


The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
09/25/14
20140286869

Rapid infusion of autologous bone marrow derived stem cells


The present invention relates to a method and composition for the aspiration, processing, testing and infusion of bone marrow derived stem cells, as an adjuvant treatment in cardiovascular disorders. More specifically, the invention provides for the methods and compositions for the aspiration, analysis, processing, infusate preparation and infusion of bone-marrow derived stem cells, particularly in a rapid point-of-care environment, wherein a centrifugal fractionation and optically monitored separation of the bone marrow yield desired cellular product in the desired concentration and viscosity..
09/18/14
20140274788

Leukemia stem cell markers


The invention provides a test method for predicting the initial onset or a recurrence of acute myeloid leukemia (aml) comprising (1) measuring the expression level of human leukemic stem cell (lsc) marker genes in a biological sample collected from a subject for a transcription product or translation product of the gene as an analyte and (2) comparing the expression level with a reference value; an lsc-targeting therapeutic agent for aml capable of suppressing the expression of a gene selected from among lsc marker genes or a substance capable of suppressing the activity of a translation product of the gene; a method for producing a sample containing hematopoietic cells for autologous transplantation or allogeneic transplantation for aml patients, comprising obtaining an lsc-purged sample with at least 1 kind of lsc marker as an index; and a method of preventing or treating aml.. .
09/18/14
20140271587

Treatment of inflammatory respiratory disease using biological solutions


Methods and therapeutic compositions for treating respiratory diseases, such as chronic obstructive pulmonary disease (copd) and devices for administering the therapeutic compositions. Methods for treatment include producing a protein solution, producing a concentrated bone marrow aspirate (cbma), optionally combining the protein solution and cbma to form an therapeutic composition, and optionally saturating the autologous therapeutic composition with hydrogen gas, and administering the therapeutic composition to a subject in need thereof.
09/18/14
20140271582

Cd123-specific chimeric antigen receptor redirected t cells and methods of their use


A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q substitution; a costimulatory signaling domain; and a t cell receptor (tcr) zeta chain signaling domain.
09/18/14
20140271356

Cpb system with dual function blood reservoir


The venous reservoir is omitted from an extracorporeal blood circuit system by substituting a blood reservoir in parallel with the arterial pump. The reservoir has an inlet connected to the outlet of the pump and an outlet connected to the inlet of the pump.
09/11/14
20140257481

Breast reconstruction device and methods


A novel human breast implant and method for using the same comprising a bioabsorbable implant into which native, autologous vascularized tissue and autologous fat is placed and propagated within a patient's chest as a breast implant.. .
09/04/14
20140249071

Enhanced anabolic cytokine production and delivery system


Techniques and devices for removing (filtering out) unwanted/inhibitory components (for example, products, byproducts and/or cell output such as inhibitory catabolic proteins) from a composition (for example, autologous fluid or serum) containing such unwanted/inhibitory components. The devices include at least one construct designed to contain a composition (for example, autologous fluid or serum) containing inhibitory/unwanted components (products, byproducts and/or output of cells such as inhibitory catabolic proteins).
09/04/14
20140248331

Polyhydroxyalkanoate medical textiles and fibers


Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate.
09/04/14
20140246802

Polyhydroxyalkanoate medical textiles and fibers


Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or nomopolymers of 4-hydroxybutyrate.
08/28/14
20140242125

Muscle tissue regeneration using muscle fiber fragments


The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle.
08/28/14
20140242118

Tumor vaccination in combination with hematopoietic cell transplantation for cancer therapy


In one aspect, the present invention provides a method for treating cancer comprising tumor cell vaccination in combination with hematopoietic and immune cell transplantation. In some embodiments, the method involves autologous tumor cell vaccination prior to autologous hematopoietic and immune cell transplantation.
08/14/14
20140228812

Method for reducing tumors and transforming cancer cells


This invention is related to a phenol-quinone therapy that shrinks tumors and transforms cancer cells. The therapy include four phases.
08/14/14
20140227339

Regenerative tissue grafts and methods of making same


A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (mpcs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. Mpcs can be harvested from debrided muscle tissue following orthopaedic trauma.
08/07/14
20140220682

Isolation, expansion and use of autologous pluripotent stem cells


The present invention relates to methods of isolating and culturing autologous pluripotent stem (aps) cells. The present invention also provides isolated aps cells, populations of aps cells and cultures of aps cells.
08/07/14
20140219980

Treatment for mitochondrial neurogastrointestinal encephalomyopathy (mngie)


The invention provides a method of treating mitochondrial neurogastrointestinal encephalomyopathy (mngie) in a patient, comprising administering to the patient autologous erythrocytes that contain thymidine phosphorylase and are free of animal proteins other than proteins derived from the patient. The erythrocytes generally contain a low amount of endotoxin..
07/31/14
20140212391

Vaginal laxity therapy utilizing cell-based bulking compositions


The invention provides methods for the treatment of vaginal laxity which include delivering a cell-containing composition to the vagina. The composition can include fat tissue to provide a bulking effect to reduce the size of the vaginal opening.
07/24/14
20140207105

Methods for effectively and rapidly desensitizing allergic patients


Methods and compositions for delivering antigens to the lymphatic system in doses that desensitize patients to future exposure to antigens have been developed. Rapid desensitization is achieved by introducing small quantities of antigen into the lymphatic system.
07/24/14
20140205676

Method of tissue repair using a composite material


A composite biocompatible hydrogel material includes a porous polymer matrix, the polymer matrix including a plurality of pores and providing a young's modulus of at least 10 gpa. A calcium comprising salt is disposed in at least some of the pores.
07/24/14
20140205514

Blood separating vessel for extracting autologous platelets, and extracting autologous platelets


Provided is a blood separating vessel for extracting autologous platelets, and an apparatus for extracting autologous platelets. The blood separating vessel for extracting autologous platelets comprises: a main body defining an internal space divided into an upper fluid chamber and a lower fluid chamber; an upper cover disposed to seal an upper portion of the upper fluid chamber; a lower cover disposed to seal a lower portion of the lower fluid chamber, the lower cover being coupled such that an outer peripheral surface of the lower cover is elevatable in a state of being in close contact along an inner peripheral surface of the lower fluid chamber by an external force applied upward; and a fluid collection part dividing the internal space into the upper fluid chamber and the lower fluid chamber and including a fluid passage protruding upward to communicate the upper fluid chamber with the lower fluid chamber..
07/10/14
20140194881

Drill, drill cover, and surgical instrument for collecting autologous bone employing same


A drill and drill cover and autogenous bone collector using the same are provided. The autogenous bone collector comprises s shaft unit connected to a driving device and a cutting unit which revolves and collects bone paticles of a patient.
06/26/14
20140178346

Cellular compositions for tissue engineering


Cell compositions for tissue engineering are provided which contain a population of autologous, minimally passaged dermal fibroblasts in combination with a tissue engineering matrix or scaffold, or material forming a matrix or scaffold. In one embodiment, the population of fibroblasts is genetically engineered to secrete a therapeutic protein in an amount effective to induce tissue growth or tissue repair when the cell composition is transplanted into a subject in need thereof.
06/19/14
20140170176

Treatment relapsing-remitting multiple sclerosis


Disclosed is a method for treating relapsing-remitting multiple sclerosis in a patient by administering to the patient autologous, ex vivo-expanded cd4+cd25+foxp3+cd127low t reg cells when the patient is in remission. Also disclosed is a method of inhibiting the activity of autoimmune, autologous cytotoxic t and b cells in a patient suffering from relapsing-remitting multiple sclerosis, comprising administering a therapeutically effective amount of autologous cd4+cd25+foxp3+cd127low t reg cells to the patient..
06/12/14
20140162355

Formulations containing and kit for using adipose-derived stem cells and use thereof


Methods and kits for producing cellular fractions enriched in adipose derived stem cells. Methods are provided where adipose tissue obtained from liposuction is enzymatically treated using a solution containing collagenase and divalent cations prior to the application of traditional methods of stromal-vascular fraction isolation.
05/22/14
20140142718

Flexible tissue matrix and methods for joint repair


A synthetic, flexible tissue matrix and methods for repairing hyaline cartilage defects in a joint using the flexible tissue matrix are described. The flexible tissue matrix includes a high molecular weight polycaprolactone polymer entangled with a polysaccharide such as hyaluronic acid.
05/22/14
20140141047

Selection of platelet rich plasma components via mineral binding


Mineral coated devices and methods for delivering an autologous biological molecule using the mineral coated devices are disclosed. The mineral coated devices allow for the isolation and delivery of a biological molecule obtained from the same subject to avoid the safety concerns of current biological therapies obtained by recombinant methods and purification from animal sources.
05/15/14
20140135925

Breast reconstruction device and methods


A novel human breast implant and method for using the same comprising a bioabsorbable implant into which native, autologous vascularized tissue and autologous fat is placed and propagated within a patient's chest as a breast implant.. .
05/08/14
20140127171

Treatment of chronic post-traumatic encephalopathy


Methods of treating chronic post-traumatic encephalopathy (pte) using regenerative approaches is described. In one embodiment, molecules with capability of stimulating endogenous neural stem cells is provided.
04/24/14
20140114070

Compounds that expand hematopoietic stem cells


The present invention relates to compounds and compositions for expanding the number of cd34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (hscs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense..
04/24/14
20140112894

Autologous cells on a support matrix for tissue repair


The present invention relates to a method for the effective treatment of tissue defects and for tissue regeneration. The method includes seeding autologous cells on a support matrix and implanting the cell-seeded support matrix into a site of transplantation.
04/24/14
20140112891

Autologous human adult pluripotent very small embryonic-like (hvsel) stem cell regeneration of bone and cartilage


The invention provides methods and compositions for the repair or regeneration of osteochondral tissue. The methods and compositions provide an effective amount of isolated differentiable human very small embryonic like stem cells (hvsels) sufficient for regeneration or repair of an osteochondral tissue.
04/17/14
20140107699

Active loaded fixation devices


The present disclosure relates to methods for producing, including intra-operatively obtaining, a fixation device, and fixation devices produced thereby, containing an autologous cell concentrate from a physiological solution, wherein the cell concentrate is isolated without the need for centrifugation.. .
04/10/14
20140101786

Generation of autologous t-cells in mice


The invention provides an animal model and methods of generating large numbers of diverse, functional, naïve t cells in mice using bone marrow cells from adult donors.. .
04/10/14
20140099383

Topical dermal formulations


An autologous topical formulation containing conditioned medium obtained from culture of autologous fibroblasts has been developed. Unlike other topical formulations, it is autologous since it is derived solely from cells obtained by the person who is to use the formulation.
04/10/14
20140099287

Plasma protein concentrate for cell delivery in regenerative applications


The invention is directed to concentrating autologously-derived plasma, using the concentrated plasma fluid to dilute the patient's cells and applying the combination of concentrated fluid with cells at a site of pathology or mixing the combination of concentrated fluid with cells with a particulate material like a bone void filler prior to placing the mixture at a site of pathology.. .


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Autologous topics: Autologous, Stem Cells, Differentiation, Fibroblast, Cell Therapy, Transplant, Cell Differentiation, Tissue Engineering, Myeloid Leukemia, Gene Expression, Acute Myeloid Leukemia, Complication, Umbilical Cord, Premature Birth, Premature Infant

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