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Autologous

Autologous-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Composite polymeric nanofibers for skin regeneration
November 09, 2017 - N°20170319744

A method for preparing a skin regeneration scaffold is disclosed. The method may include preparing a polymer solution by dissolving a biopolymer in a solvent, and subjecting the polymer solution to a template-assisted extrusion process with a nanoporous material as a template in order to produce polymer nanofibers. Furthermore, the method includes fabricating a multilayer composite nanofibrous scaffold using the ...
Artificial antigen-presenting cells and methods for producing and using the same
Indiana University Research And Technology Corporation
October 26, 2017 - N°20170304462

Described herein are biomimetic janus particles useful as artificial antigen presenting cells capable of activating t cells in vitro. “bull's eye” ligand patterns mimicking either the native or reverse organization of the t cell immunological synapse are provided on the surface of nano- or micro-sized particles. Methods for activating t cells in vitro using biomimetic janus ...
Method and composition for producing enhanced anti-inflammatory/ anti-catabolic and regenerative agents from autologous physiological fluid
Indiana University Research And Technology Corporation
October 19, 2017 - N°20170296583

Described are methods of producing an autologous composition useful for treatment of damaged and/or injured connective tissues, chronic tendinosis, chronic muscle tears and/or chronic degenerative joint conditions and skin inflammatory disorders in a mammal. The method comprises preparing an anti-inflammatory/anti-catabolic component of the autologous composition comprising il-1ra and timps. An anti-inflammatory/anti-catabolic component is prepared comprising: ...
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Stromal vascular fraction processing devices and methods
Flex Partners
October 12, 2017 - N°20170292110

Disclosed herein are systems, devices and methods for processing tissue, such as autologous tissue. Implementations of a stromal vascular fraction (svf) system are described that can isolate and wash harvested cells contained within various tissues, such as isolate and wash stem cells from fat tissue. The svf system can minimize the handling and transferring of tissue and fluids, including minimizing ...
Predicting allergic reactions
Alcyomics Ltd
October 05, 2017 - N°20170285001

This present invention provides a method of predicting immunogenicity and hypersensitivity or allergic reactions to chemical compounds, therapeutics, cosmetics and other chemical compositions. The method uses an in vitro assay employing autologous blood derived cells and an autologous cultured skin biopsy and is of particular utility in the identification and prediction of skin sensitizers that cause allergic contact dermatitis.
Compounds and methods for kinase modulation, and indications therefor
Alcyomics Ltd
October 05, 2017 - N°20170283423

In certain aspects and embodiments, the described compounds or salts thereof, formulations thereof, conjugates thereof, derivatives thereof, forms thereof are active on one or more of fms, kit, flt3, trka, trkb and trkc kinase protein. Also described are methods of use thereof to treat diseases and conditions, including diseases and conditions associated with activity of one or more of fms, ...
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Glycolipid containing compositions for use in the treatment of tumours
Agalimmune Limited (gb/gb)
September 21, 2017 - N°20170266214

The invention relates to pharmaceutical compositions comprising α-gal boel for use in treating patients with tumors. The invention also relates to methods of treating tumours using said compositions. The invention discloses that following intratumoral injection of α-gal boel, binding of the natural anti-gal antibody to de novo expressed tumoural α-gal epitopes induces inflammation resulting ...
Treatment for chronic myocardial infarct
Biocardia, Inc.
September 21, 2017 - N°20170266107

A method of treating chronic post-myocardial infarction including helical needle transendocardial delivery of autologous bone marrow (abm) mononuclear cells around regions of hypo or akinesia in chronic post-myocardial infarction (mi) patients. The treatment is safe and improves ejection fraction (ef).
Method for digital archiving and manufacturing of dental prosthetics and prosthesis, and teaching and training ...
Eped Inc.
September 21, 2017 - N°20170265972

A method for digital archiving and manufacturing of dental prosthetics and a prosthesis, and teaching and training for same are provided. The method mainly includes the following steps: preoperative scanning: creating a first digital model file; optical positioning and turning treatment: creating a second digital model file from a turning process; physical model calculation: creating reversely an autologous crown model ...
Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170261508

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response ...
Cd123-specific chimeric antigen receptor redirected t cells and methods of their use
City Of Hope
September 14, 2017 - N°20170260277

A family of chimeric antigen receptors (cars) containing a cd123 specific scfv was developed to target different epitopes on cd123. In some embodiments, such a cd123 chimeric antigen receptor (cd123car) gene includes an anti-cd123 scfv region fused in frame to a modified igg4 hinge region comprising an s228p substitution, an l235e substitution, and optionally an n297q ...
Autologous pleurodesis methods and devices
Carefusion 2200, Inc.
September 14, 2017 - N°20170259038

System and components for inducing pleurodesis or other sclerosis or desired adhesion conditions to treat a patient, while minimizing likelihood of tissue damage from direct application of sclerosis-enhancing materials. A tube device is provided that is configured to elute sclerosis-enhancing material and/or other medicaments including autologous or otherwise patient compatible blood and/or blood component(s) via an assembly ...
Systems and methods for preparing a thrombin serum
Arthrex, Inc.
September 14, 2017 - N°20170258877

A system for preparing a thrombin serum includes a containment device, a cage received within the containment device, a cap attachable to the containment device, an inlet port configured to introduce a non-anti-coagulated autologous blood fluid into the containment device, and an outlet port.
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Methods and compositions for treating ovarian failure
Augusta University Research Institute, Inc.
September 14, 2017 - N°20170258842

Methods and compositions for treating ovarian failure are provided. In one embodiment, the method includes administering stem cells into the ovary of a female subject in need of such treatment. The stem cells are preferably bone marrow derived stem cells (bmsc). In other embodiments, the stem cells are embryonic stem cells, adult stem cells, induced stem cells, induced pluripotent stem ...
Percutaneous aspirating cannula
Adimend Biosciences, Llc
September 14, 2017 - N°20170258459

The dual syringe with percutaneous cannula is a medical device for harvesting and transferring cells for autologous transplantation without the requirement of a surgical setting or ambulatory care. The dual syringe is a closed sterile system that allows for the harvesting syringe to harvest the cells/tissue from a first location of a patient which is then centrifuged to aggregate ...
Autologous implantation of chimeric murine-human tumors, generated in pdx mice, for ativation of an anti-tumor ...
Adimend Biosciences, Llc
September 07, 2017 - N°20170252371

Here, we present a specific and novel method for treating cancer by eliciting an anti-tumor immune response in cancer patients. Specifically, this technique involves subcutaneous “auto-im-transplantation” of chimeric murine-human tumors, created in pdx mice, back to the original donor patients. This is an approach to personalized cancer therapy, which does not require identification of specific tumor ...
Systems, compositions, and methods for transplantation and treating conditions
Cytonics Corporation
August 31, 2017 - N°20170246372

Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (a2m) from whole blood and or recombinant a2m are provided. Also provided are methods of treating wounds with a2m. Methods for utilizing a2m in combination with other treatments (e. G., platelets and other growth factors) are provided in addition to combinations with exogenous drugs or ...
Compositions and methods for treating b cell mediated autoimmune disorders
Opexa Therapeutics, Inc.
August 31, 2017 - N°20170246272

Provided herein are methods, kits, compositions and uses related to the treatment of a b cell mediated autoimmune disorder with a t cell vaccine comprising a therapeutically effective amount of t cells autologous to the patient and that react to an autoantigen or specific epitope(s) thereof associated with the b cell mediated autoimmune disorder, wherein the treatment is provided ...
Derivation of embryonic stem cells and embryo-derived cells
Astellas Institute For Regenerative Medicine
August 24, 2017 - N°20170240857

This present invention provides novel methods for deriving embryonic stem cells and embryo-derived cells from an embryo without requiring destruction of the embryo. The invention further provides cells and cell lines derived without embryo destruction, and the use of the cells for therapeutic and research purposes. It also relates to novel methods of establishing and storing an autologous stem cell ...
Autologous hiv-1 proteins for the treatment of latent hiv-1 infection
Case Western Reserve University
August 24, 2017 - N°20170239325

A method of reducing a latent hiv-specific memory-cd4+ t cell pool in a subject includes the steps of: preparing at least one hiv-1 protein coding sequence from a sample obtained from the subject, wherein the sample includes hiv-1 rna; introducing the at least one hiv-1 protein coding sequence into at least one expression construct using yeast homologous recombination; transfecting a ...
Compounds that expand hematopoietic stem cells
Novartis Ag
August 24, 2017 - N°20170239296

The present invention relates to compounds and compositions for expanding the number of cd34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (hscs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages ...
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