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Autologous patents

      

This page is updated frequently with new Autologous-related patent applications.




 Fusion proteins of collagen-binding domain and parathyroid hormone patent thumbnailFusion proteins of collagen-binding domain and parathyroid hormone
Fusion proteins containing active agonist or antagonist fragments of parathyroid hormone (pth) and parathyroid hormone related peptide (pthrp) coupled to a collagen-binding domain are presented. The fusion proteins can be used to promote bone growth, to promote hair growth, to prevent cancer metastasis to bone, to promote immune reconstitution with a bone marrow stem cell transplant, to promote mobilization of bone marrow stem cells for collection for autologous stem cell transplant, and to treat renal osteodystrophy.
The Board Of Trustees Of The University Of Arkansas


 Vaccination with immuno-isolated cells producing an immunomodulator patent thumbnailVaccination with immuno-isolated cells producing an immunomodulator
Provided herein are vaccine compositions containing at least one retrievable biocompatible macrocapsule containing immuno-isolated allogeneic cells that secrete an immunomodulator such as gm-csf (granulocyte-macrophage colony stimulating factor) and an antigenic component such as autologous tumor cells or infectious agents. Also provided are kits and pharmaceutical compositions containing the vaccine compositions as well as methods of use thereof for therapeutic or preventative vaccination against tumors or infectious agents..
Maxivax Sa


 Vaccination with immuno-isolated cells producing an immunomodulator patent thumbnailVaccination with immuno-isolated cells producing an immunomodulator
Provided herein are vaccine compositions containing at least one retrievable biocompatible macrocapsule containing immuno-isolated allogeneic cells that secrete an immunomodulator such as gm-c sf (granulocyte-macrophage colony stimulating factor) and an antigenic component such as autologous tumor cells or infectious agents. Also provided are kits and pharmaceutical compositions containing the vaccine compositions as well as methods of use thereof for therapeutic or preventative vaccination against tumors or infectious agents..
Maxivax Sa


 Plasma-enriched hydroxyapatite-based filler material and  filling bone gaps with the same patent thumbnailPlasma-enriched hydroxyapatite-based filler material and filling bone gaps with the same
Plasma-enriched hydroxyapatite-based fillers and methods of filling bone gaps in oral surgery, orthopedic procedures, and cosmetic surgery are disclosed. The fillers contain a substance comprising an anticoagulant antidote, a substance comprising hydroxyapatite, and blood or plasma.
Metrex Research, Llc


 Expanded utility of red-cell derived microparticles (rmp) for treatment of bleeding patent thumbnailExpanded utility of red-cell derived microparticles (rmp) for treatment of bleeding
Red blood cell membrane derived microparticles (rmp) are safe, economical, effective hemostatic agents in the treatment of a wide range of bleeding conditions and can, therefore, be considered as universal hemostatic agents. Effective rmp are produced from red blood cells using a high-pressure extrusion membrane shear process.
University Of Miami


 Failsafe percutaneous wound barrier patent thumbnailFailsafe percutaneous wound barrier
Provided are approaches to establish a failsafe barrier to internal bleeding from percutaneous wounds. As provided herein, a barrier is formed to protect a patient from failed wound closure devices or related complications due to a variety of contributing factors such as state of systemic anticoagulation, errors in surgical procedure, variability in patient anatomy, and the like.

 Fgf-18 in graft transplantation and tissue engineering procedures patent thumbnailFgf-18 in graft transplantation and tissue engineering procedures
The present invention provides a new method related to regenerative medicine for the treatment of cartilage disorders, osteoarthritis and cartilage injury in particular. More particularly, it relates to an fgf-18 compound for use in tissue engineering and graft procedures, such as osteochondral or cartilage transplantation or autologous chondrocyte implantation (aci)..
Merck Patent Gmbh


 Combined autologous biologic and cold therapy treatment of skin injuries patent thumbnailCombined autologous biologic and cold therapy treatment of skin injuries
This disclosure describes a combined autologous biologic and cold therapy treatment for treating various skin injuries. The treatment may include applying autologous blood components, including but not limited to platelet rich plasma, to a skin injury in a manner that influences the healing process.
Arthrex, Inc.


 Combined autologous biologic and cold therapy treatment of skin injuries patent thumbnailCombined autologous biologic and cold therapy treatment of skin injuries
This disclosure describes a combined autologous biologic and cold therapy treatment for treating various skin injuries. The treatment may include applying autologous blood components, including but not limited to platelet rich plasma, to a skin injury in a manner that influences the healing process.
Arthrex, Inc.


 Polymeric substrates with immobilized antibodies and  production thereof patent thumbnailPolymeric substrates with immobilized antibodies and production thereof
The present invention relates to biofunctional polymeric substrates product comprising immobilized antibodies that selective bind to antigens namely autologous growth factors and an inflammatory molecule, uses and method of production. The bio-functional polymeric substrate can be used in a quantification method of antigens namely soluble growth factors, inflammatory molecules and hormones or the biofunctional polymeric substrate can be used to isolate extracellular vesicules.
Association For The Advancement Of Tissue Engineering And Cell Based Technology And Therapie


Multi-indication mrna cancer immunotherapy

Synthetic bacterial messenger rna can be used to prepare autologous, allogenic or direct nucleic acid cancer vaccines. Cancer cells are transfected either in vitro or in vivo with mrna obtained from dna that encodes an immunogenic bacterial protein.
Morphogenesis, Inc.

Tissue marking implant

A prosthesis includes an outer capsule that is made of biosorbable material. An inner capsule is encapsulated by the outer capsule.
Senorx, Inc.

Vascular prosthesis

A vascular prosthesis configured for direct connection to an artery. The vascular prosthesis may include a tube of material other than autologous vascular tissue, having an end formation, which is configured for surgical connection to an opening formed in the artery, and a narrower portion prior to commencement of the end formation.
Bard Peripheral Vascular, Inc.

Treatment of vocal cords with autologous dermal fibroblast formulation

Dosage units consist of an autologous cell therapy product composed of fibroblasts grown for each individual to be treated for augmentation or regeneration of vocal cords. The suspension of autologous fibroblasts, grown from a biopsy of each individual's own buccal mucosa or skin using current good manufacturing practices (cgmp) and standard tissue culture procedures, is supplied in vials containing cryopreserved fibroblasts or precursors thereof, having a purity of at least 98% fibroblasts and a viability of at least 85%, for administration of from one to six ml, preferably two ml administered three times approximately three to six weeks apart, of cells at a concentration of from 1.0-2.0×107 cells/ml..
Fibrocell Technologies, Inc.

Systems and methods for endoluminal valve creation

The present application pertains generally to medical systems and methods for creation of an autologous tissue valves within a mammalian body. In some embodiments, a system for creating an endoluminal valve from a blood vessel wall is provided.
The Board Of Trustees Of The Leland Stanford Junior University

Systems and methods for endoluminal valve creation

The present application pertains generally to medical systems and methods for creation of an autologous tissue valves within a mammalian body. In some embodiments, a system for creating an endoluminal valve from a blood vessel wall is provided.
The Board Of Trustees Of The Leland Stanford Junior University

Canine autologous immunotherapy using dendritic cell induced cancer killing immunocytes

Described are compositions of matter, protocols, and treatment means for induction of immune mediated killing in dogs suffering from cancer. The invention provides means of extracting peripheral blood from a canine patient, expanding immunocytes capable of killing cancer cells in vitro, and re-administering said immunocytes into a patient in need of therapy.
Zander Therapeutics, Inc.

Gene editing for immunological destruction of neoplasia

Disclosed are methods, protocols, and compositions of matter useful for induction and/or propagation of antitumor immune responses through gene editing of immunocytes. Stimulation of antitumor adaptive immunity is achieved through gene editing of autologous or allogeneic lymphocytes in a manner to derepress neoplasia induced suppression.
Batu Biologics Inc.

Methods and systems for endometrial treatment

Methods of treating endometrial dysfunction are described including retrieval of endometrial cells including endometrial stem cells from a fertile donor and transplantation of endometrial cells or tissue into a host suffering from endometrial dysfunction. In certain embodiments, methods include genetic modification, tissue culturing, or cryopreservation of the endometrial cells prior to transplantation.
Celmatix Inc.

Apparatus and determining the liquid level of salvaged blood in a blood collection reservoir of an autologous blood transfusion system

Disclosed is an apparatus and method for determining the liquid level of salvaged blood in a blood collection reservoir (11) of an autologous blood transfusion system (20), comprising sensing means (10, 12) for periodically sensing the liquid level of the salvaged blood in said blood collection reservoir (11) and outputting corresponding signals, and determining means (2) for determining the liquid level of the salvaged blood in said blood collection reservoir (11) based on said output signal of said sensing means. The sensing means comprises a plurality of light emitters (12) disposed on a first side of said blood collection reservoir (11) at different height levels (l1-l9) for emitting light and a plurality of light receivers (10) disposed at said different height levels (l1-l9) on a second side of said blood collection reservoir (11) opposite to said first side for sensing light emitted by said light emitters (12) and transmitted through said blood collection reservoir (11).
Fresenius Kabi Deutschland Gmbh

Lamina implant and method

A prosthetic implant for restoring lamina after a laminectomy. The implant is generally a lamina-sized construct having a hollow interior.
Globus Medical, Inc.

Methods of primary tissue culture and drug screening using autologous serum and fluids

The present invention provides methods for culturing primary cells and tissues from a subject in the presence of the subject's own serum, ascites or pleural effusion fluid. Methods of treating cancer, and screening for the effectiveness or toxicity of drugs are also provided herein..

Device to optimize cosmetic injectable procedures

The present invention provides a system consisting of a handheld device with integrated power source. The system will be designed to perform several treatment (massage) modalities and will be used to optimize outcome following cosmetic injectable procedures.
Aesthetic Medical Devices

Dna vector and transformed tumor cell vaccines

Customized whole cell cancer vaccines can be produced from autologous (ex vivo or in situ) or allogeneic human or veterinary patient cell lines. Cells are transformed with s.
Morphogenesis, Inc.

Systems and methods for repairing soft tissues

A wicking component is integrated into an arthroscopically deployable bone anchor, and is intended to improve soft tissue-to-bone repair. Once deployed, the fibrous wick component extends from within the bone tunnel, out of the hole, and to the bone-tendon interface on the bone surface.
Cayenne Medical, Inc.

Multilineage stem cells derived from the peripheral blood and uses thereof

The present invention discloses recovery and isolation of mesenchymal stem cells from the peripheral blood. This has an advantage of being able to obtain multilineage inducible cells from readily obtainable and autologous allogenic blood.
Vivex Biomedical, Inc.

Tissue grafts and methods of making and using the same

In some embodiments, the present invention provides tissue grafts, such as vascularized bone grafts, and methods for preparing and using such tissue grafts. In some embodiments the tissue grafts are made using pluripotent stem cells, such as autologous pluripotent stem cells.
The New York Stem Cell Foundation

Polyhydroxyalkanoate medical textiles and fibers

Absorbable polyester fibers, braids, and surgical meshes with prolonged strength retention have been developed. These devices are preferably derived from biocompatible copolymers or homopolymers of 4-hydroxybutyrate.
Tepha, Inc.

Method for obtaining immuno-stimulatory dendritic cells

The present invention relates to methods for producing immuno-stimulatory autologous dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from hyper-proliferative disease such as cancer..
Yale University

Muscle tissue regeneration using muscle fiber fragments

The invention is directed to methods and compositions for obtaining uniform sized muscle fiber fragments for transplantation. These muscle fiber fragments are able to reconstitute into long fibers that are oriented along native muscle.
Wake Forest University Health Sciences

Composition and methods of genome editing of b-cells

The present invention provides methods compositions and methods of preparing autologous (or allogeneic) b cells that secrete a monoclonal of interest useful in immunotherapy or b cells with an altered function.. .
Dana-farber Cancer Institute, Inc.

Surgical methods/devices for tissue injury removal by tattooing of autologous stem cells

A method and a device for autografting of fat microparticles containing stem cells of various types, injected into scars, or stretch marks, and/or other cutaneous injuries, at epidermis-dermis level is presented. Fat is taken from the patient in the periumbilical area, where large quantities of mesenchymal stem cells exist.

Anti-wt1/hla bi-specific antibody

Disclosed herein is a bi-specific form of a t cell receptor mimic (tcrm) mab with reactivity to human immune effector cell antigen and a wt1 peptide/hla-a epitope. This antibody selectively bound to leukemias and solid tumor cells expressing wt1 and hla-a as well as activated resting human t cells to release interferon-(ifn-γ) and to kill the target cancer cells in vitro.
Eureka Therapeutics, Inc.

Method of treating a pathological syndrome and a pharmaceutical agent

Pharmaceutical agent for treating a pathological syndrome contains activated form of ultra-low doses of monoclonal, polyclonal or natural antibodies to an antigen, wherein said activated form is prepared by means of repeated consecutive dilution and external treatment, predominantly based on homeopathic technology, and said antigen is a substance or a drug acting as a direct cause of the pathological syndrome or involved in regulation of mechanisms of its formation. At that, activated forms of ultra-low doses of antibodies are raised against antigens of exogenous or endogenous origin, against autologous antigens, fetal antigens; anti-idiotypic antibodies are used too..

Systems, compositions, and methods for transplantation and treating conditions

Systems and methods for purification and concentration of autologous alpha-2 macroglobulin (a2m) from whole blood and or recombinant a2m are provided. Also provided are methods of treating wounds with a2m.
Cytonics Corporation

Methods for monitoring cd4+ t-helper type 1 response in cancer and immune restoration

A method for diagnosing or treating a mammalian subject having, or at risk of developing cancer, comprising: generating a circulating anti-cancer cd4+ th1 response from antigen presenting cells or their precursors and cd4+ t-cells from a sample of said subject's blood which causes secretion of interferon-gamma (“ifn-γ”); and detecting said anti-cancer cd4+ th1 response to determine if said response is depressed. A method for restoring her2-specific cd4+ th1 immune response in a her2-positive breast cancer patient in need thereof, comprising: administering to said patient a therapeutically effective amount of a dendritic cell (“dc”) vaccine comprising autologous dcs pulsed with her2-derived mhc class ii binding peptides (“dc vaccination”) to elevate said patient's anti-her2 cd4+ th1 response; and measuring said anti-her2 th1 response of said patient pre- and post-dc vaccination to determine the amount of increase in said response..

Semi-allogenic anti-tumour vaccine with hla haplo-identical antigen-presenting cells

The present invention relates to semi-allogeneic antigen-presenting cells into which proteins and/or peptides or rna or dna or cdna, respectively, encoding said proteins and/or peptides which are overexpressed in tumor cells or which are derived from autologous tumor cells or different tumor cells or different tumor cell lines have been introduced. Furthermore the invention relates to methods for the generation of these semi-allogeneic antigen-presenting cells as well as to the use thereof in the treatment of tumor diseases..
Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (gmbh)

Biomarkers for cell therapy

The invention relates to methods for monitoring progression of an inflammatory condition in a subject in particular embodiments the patient is undergoing treatment of the inflammatory condition and the method comprises monitoring the level of one or more biomarkers to monitor disease progression, for example to assist the clinician in optimising the treatment regimen. In particular embodiments the subject is undergoing treatment with mesenchymal stem cells (mscs).
Cell Ideas Pty Ltd

Tissue processing device and associated systems and methods

Tissue processing devices are provided. The tissue processing devices can be used to process and transport tissue in a closed and continuous environment.
Lifecell Corporation

Probiotic enhancement of steroid and immune suppressor activity in mammals with chronic diseases

This invention relates to use of probiotics, particularly p acidilactici and s boulardii, for use in conjunction with steroids and other immune suppressor agents to ameliorate symptoms of autoimmune diseases, especially disease symptoms arising from the body's production of antibodies against autologous blood cells. The practice of the invention sustains ameliorative response associated with immune suppressor agents while lowering the amount of immune suppressor agents required for treatment..
Imagilin Technology, Llc

Compositions and methods for restoring or rejuvenating stem/progenitor cell function

This invention relates to the use of autologous stem/progenitor cells to restore or rejuvenate adult stem cell function in a mammal, wherein the restoration or rejuvenating extends lifespan and/or improves health of the mammal. In addition, the invention also relates to compositions containing one or more regulatory factors secreted or released from isolated mammalian stem/progenitor cells and use of such compositions to extend lifespan and/or improve health of a mammal.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education

Methods and compositions for ex vivo generation of developmentally competent eggs from germ line cells using autologous cell systems

The present technology provides for methods for the directed differentiation of multi-potent cells, female germ line stem cells, or oogonial stem cells into oocytes, granulosa cells and/or granulosa precursor cells, i.e.,“synthetic granulosa cells.” the synthetic granulosa cells are useful in methods for growth and maturation of follicles or follicle-like structures and immature oocytes. Additionally, the synthetic granulosa cells are useful in methods of increasing ovarian derived hormones and growth factors in a subject in need thereof..
Northeastern University

Formulation, apparatus, and methods for treatment of brain trauma

A formulation comprising platelet rich plasma (prp) for treatment of patients who have experienced brain injury, consisting of a mixture of human autologous plasma, d5w, glutathione, methylcobalamin, and regular insulin. The formulation is infused directly adjacent to a patient's brain through the nostrils or nares of the nasal cavity.

Device and surgical system for rapid aseptic isolation and concentration of autologous fat derived stem cells

The present disclosure provides an apparatus for harvesting stem cells from fat tissue. The apparatus may include a first transducer coupled to a first end of an resonant horn to form an ultrasonic resonator.

Self-contained device and system to produce ex-vivo autologous whole cell tumor vaccines

The invention disclosed herein aims to standardize and simplify the process of preparing ex-vivo autologous whole tumor cell vaccines. The present invention is a robust, stand-alone device and system for preparing autologous tumor cell vaccines in a completely self-contained sterile environment, and in a shortened time.

Bone tissue engineering by ex vivo stem cells ongrowth into three-dimensional trabecular metal

Adult autologous stem cells cultured on a porous, three-dimensional tissue scaffold-implant for bone regeneration by the use of a hyaluronan and/or dexamethasone to accelerate bone healing alone or in combination with recombinant growth factors or transfected osteogenic genes. The scaffold-implant may be machined into a custom-shaped three-dimensional cell culture system for support of cell growth, reservoir for peptides, recombinant growth factors, cytokines and antineoplastic drugs in the presence of a hyaluronan and/or dexamethasone alone or in combination with growth factors or transfected osteogenic genes, to be assembled ex vivo in a tissue incubator for implantation into bone tissue..

Clinical applications of formulations containing adipose-derived stem cells

Methods and kits for producing cellular fractions enriched in adipose derived stem cells. Methods are provided where adipose tissue obtained from liposuction is enzymatically treated using a solution containing collagenase and divalent cations prior to the application of traditional methods of stromal-vascular fraction isolation.
Antria, Inc.

Autologous cancer cell vaccine

An autologous cancer cell vaccine comprises cancer cells that express both mhci and mhcii on their cell surface. The mhci presents a cancer antigen and the mhcii presents a non-self antigen..

Method of preparing autologous cells and methods of use for therapy

A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium which can be used in a clinical setting, and a business method for performing such expansions in the future as a service for patients. A method for expanding mesenchymal cells derived from autologous bone marrow in autologous culture medium including a diagnostic kit for the autologous cell therapy to determine whether a patient will respond to the autologous cell therapy for treatment of a disease, in which said kit comprising a system for detecting gene and protein expression comprising at least two isolated dna molecules wherein each isolated dna molecule detects expression of a gene that is differentially expressed in the tissue of the patient that is intended to be the source of the autologous cell therapy..
Biocardia, Inc.



Autologous topics:
  • Autologous
  • Stem Cells
  • Differentiation
  • Fibroblast
  • Cell Therapy
  • Transplant
  • Cell Differentiation
  • Tissue Engineering
  • Myeloid Leukemia
  • Gene Expression
  • Acute Myeloid Leukemia
  • Complication
  • Umbilical Cord
  • Premature Birth
  • Premature Infant


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    This listing is a sample listing of patent applications related to Autologous for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Autologous with additional patents listed. Browse our RSS directory or Search for other possible listings.


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