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Autoimmune patents



      

This page is updated frequently with new Autoimmune-related patent applications.




Date/App# patent app List of recent Autoimmune-related patents
05/19/16
20160138022 
 Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response patent thumbnailImmune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist.
Idera Pharmaceuticals, Inc.


05/19/16
20160138021 
 Compositions and methods for treating cancer and other diseases patent thumbnailCompositions and methods for treating cancer and other diseases
Aptamers and improved aptamers are provided with enhanced efficacy for binding to target molecules in vivo or for treating cancer or other diseases. Such improvements in aptamers are provided that enhance in vivo efficacy such as binding to the target molecule or enhancing anti-cancer activity.
Memorial Sloan Kettering Cancer Center


05/19/16
20160137741 
 Muscle specific tyrosine kinase-fluorophore conjugate compositions, kits and methods of using patent thumbnailMuscle specific tyrosine kinase-fluorophore conjugate compositions, kits and methods of using
Provided herein is a method of diagnosing muscle specific tyrosine kinase specific autoimmune myasthenia gravis in an individual. Generally, in the method a level of muscle specific tyrosine kinase binding to b cells is determined in a sample from an individual.

05/19/16
20160137734 
 Therapeutic cd47 antibodies patent thumbnailTherapeutic cd47 antibodies
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, cd47, as well as monoclonal antibodies and antigen binding fragments thereof that compete with the former for binding to cd47. Also provided are combinations of any of the foregoing.
Vasculox Inc.


05/19/16
20160137733 
 Therapeutic cd47 antibodies patent thumbnailTherapeutic cd47 antibodies
Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, cd47, as well as monoclonal antibodies and antigen binding fragments thereof that compete with the former for binding to cd47. Also provided are combinations of any of the foregoing.
Vasculox Inc.


05/19/16
20160137731 
 Human anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor patent thumbnailHuman anti-pd-1, pd-l1, and pd-l2 antibodies and uses therefor
The present invention is based, in part, on the identification of novel human anti-pd-1, pd-l1, and pd-l2 antibodies. Accordingly, the invention relates to compositions and methods for diagnosing, prognosing, and treating conditions that would benefit from modulating pd-1, pd-l1, and/or pd-l2 activity (e.g., persistent infectious diseases, autoimmune diseases, asthma, transplant rejection, inflammatory disorders and tumors) using the novel human anti-pd-1, pd-l1, and pd-l2 antibodies described herein..
Emory University


05/19/16
20160137729 
 Anti cd37 antibodies patent thumbnailAnti cd37 antibodies
Chimeric and humanized anti-cd37 antibodies and pharmaceutical compositions containing them are useful for the treatment of b cell malignancies and autoimmune and inflammatory diseases that involve b cells in their pathology.. .
Boehringer Ingelheim International Gmbh


05/19/16
20160137713 
 Fcrn-specific human antibody and composition for treatment of autoimmune diseases patent thumbnailFcrn-specific human antibody and composition for treatment of autoimmune diseases
The present invention relates to a human antibody specific for fcrn that is a receptor with a high affinity for igg, a production method thereof, a composition for treating autoimmune disease, which comprises the antibody, and a method of treating and diagnosing autoimmune disease using the same. The fcrn-specific antibody according to the present invention can bind to fcrn non-competitively with igg or the like to reduce serum auto-antibody levels, and thus can be used for the treatment of autoimmune diseases..
Hanall Biopharma Co., Ltd.


05/19/16
20160137646 
 Novel compounds and uses thereof patent thumbnailNovel compounds and uses thereof
The present invention provides novel compounds of any one of formulae (i)-(iv), and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of any one of formulae (i)-(iv) and pharmaceutical compositions thereof that are mucus penetrating.
Kala Pharmaceuticals, Inc.


05/19/16
20160137613 
 Novel anti-inflammatory agents patent thumbnailNovel anti-inflammatory agents
Disclosed are novel compounds that are useful in regulating the expression of interleukin-6 (il-6) and/or vascular cell adhesion molecule-1 (vcam-1), and their use in the treatment and/or prevention of cardiovascular and inflammatory diseases and related disease states, such as, for example, atherosclerosis, asthma, arthritis, cancer, multiple sclerosis, psoriasis, and inflammatory bowel diseases, and autoimmune disease(s). Also, disclosed are compositions comprising the novel compounds, as well as methods for their preparation..
Resverlogix Corp.


05/19/16
20160137608 

Substituted benzoazepines as toll-like receptor modulators


Provided are compositions and methods useful for modulation of signaling through the toll-like receptors tlr7 and/or tlr8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, infectious disease, inflammatory disorder, graft rejection, and graft-verses-host disease..
Array Biopharma, Inc.


05/19/16
20160136272 

Methods for restoring corticosteroid sensitivity


The present invention relates to use of therapeutic agents that specifically bind and inhibit tlr3 signalling in order to sensitize patients to treatment with corticosteroids, notably for the treatment and prevention of inflammatory and autoimmune disorders.. .
Innate Pharma


05/19/16
20160136267 

Sphingoglycolipid analogues


The invention relates to sphingoglycolipid analogues which are useful in treating or preventing diseases and conditions such as those relating to infection, atopic disorders, autoimmune diseases or cancer.. .
Victoria Link Limited


05/12/16
20160131646 

Detection and treatment of autoimmune disorders


Disclosed herein are methods of treatment of autoimmune diseases such as systemic lupus erythematosus (sle) as well as clinical assays for detection of autoimmune disease activity in patients utilizing a pd1 ligand.. .
Seattle Children's Hospital


05/12/16
20160130552 

Method for obtaining immuno-suppressive dendritic cells


The present invention relates to methods for producing immuno-suppressive dendritic cells. The present invention further relates to the use of such cells for treating patients suffering from autoimmune diseases, hypersensitivity diseases, rejection on solid-organ transplantation and/or graft-versus-host disease..
Yale University


05/12/16
20160130360 

Her2/neu-specific antibodies and methods of using same


This invention relates to antibodies that specifically bind her2/neu, and particularly chimeric 4d5 antibodies to her2/neu, which have reduced glycosylation as compared to known 4d5 antibodies. The invention also relates to methods of using the 4d5 antibodies and compositions comprising them in the diagnosis, prognosis and therapy of diseases such as cancer, autoimmune diseases, inflammatory disorders, and infectious disease..
Macrogenics, Inc.


05/12/16
20160130343 

Anti-ilt7 antibody


An antibody binding to ipc was obtained by using an animal cell in which a cell membrane protein associatable with ilt7 was co-expressed as an immunogen. The antibody of the invention has a high specificity which allows immunological distinction between other ilt family molecules and ilt7.
Sbi Biotech Co., Ltd.


05/12/16
20160130333 

Chimeric and humanized anti-histone antibodies


The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific cdr sequences, disclosed herein. Preferably, the antibodies or fragments comprise specific heavy and light chain variable region sequences disclosed herein.
Immunomedics, Inc.


05/12/16
20160130318 

Interleukin 15 (il-15) antagonists and uses thereof for the treatment of autoimmune diseases and inflammatory diseases


The present relates to interleukin 15 (il-15) antagonists and uses thereof, in particular for the treatment of autoimmune diseases and inflammatory diseases. In particular, the present invention relates to an il-15 mutant polypeptide having the amino acid sequence as set forth in seq id no:1 wherein the leucine residue at position 45 is substituted by an aspartic acid residue, the asparagines residue at position 65 is substituted by a lysine residue and the leucine residue at position 69 is substituted by an arginine residue.
Universite D'angers


05/12/16
20160130251 

Apoptosis signal-regulating kinase inhibitors


Wherein x1, x2, x3, x4, x5, x6, x7, x8, r1, r2, r3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases.



Autoimmune topics: Autoimmune, Immune Disease, Autoimmune Disease, Immune Diseases, Autoimmune Diseases, Transplant, Immune Disorder, Autoimmune Disorder, Autoimmune Disorders, Infectious, Infectious Disease, Inflammatory Disease, Type 1 Diabetes, Proliferative Disorder, Recurrence

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