|| List of recent Autoimmune-related patents
|Detection of histone modification in cell-free nucleosomes|
This invention relates to the diagnosis of disease conditions, such as cancer and autoimmune disease, by the analysis of cell-free nucleosomes in samples from individuals. Methods of the invention may include contacting cell-free nucleosomes from a biological fluid sample obtained from the individual with an antibody that binds specifically with a modified histone protein.
Singapore Volition Pte. Limited
|Screening methods to identify compounds useful in the prevention and/or treatment of inflammatory conditions|
The present invention relates to methods and assays for identifying agents capable of modulating gpr84 activity in cells, in particular agents that inhibit gpr84-agonist stimulated chemotaxis. Inhibition of gpr84-agonist stimulated chemotaxis is useful in the prevention and/or treatment of inflammatory conditions.
|Design of oligonucleotide analogs as therapeutic agents|
It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.. .
|Depletion of il23r expressing cells in the treatment of various diseases|
The present invention relates, for example, to depletion of il23r expressing cells in the treatment of disease and, in an embodiment thereof, to bispecific constructs that specifically bind to immune effector cells and, simultaneously, to il23r-carrying target cells, as well as nucleic acids, vectors, host cells, pharmaceutical compositions, and methods of production and use thereof, including such bispecific constructs for use in, for example, treating inflammatory and/or autoimmune diseases and/or cancer.. .
Compounds which are tricyclopyrazole derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of aids development in hiv-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under solid phase synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.. .
Nerviano Medical Sciences S.r.l.
|Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases|
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-2 protein.. .
The Walter And Eliza Hall Institute Of Medical Research
|Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule|
The present invention relates to novel acetylenedicarboxyl linkers used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking pairs of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders..
Sushou M-conj Biotech Co., Ltd
|Systems and methods to improve organ or tissue function and organ or tissue transplant longevity|
The present invention provides for systems and methods for inhaled co therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack..
|Progranulin as marker for autoimmune disorders|
The present invention provides for means and method for the detection and/or the quantification of anti-progranulin-autoantibodies in a biological sample of a subject. The present invention also provides for means and method for the detection and/or the quantification of hyper-phosphorylated progranulin in a biological sample of a subject.
Universitaet Des Saarlandes
|Methods and kits for determining a placebo profile in subjects for clinical trials and for treatment of patients|
The present invention is directed to methods and assays for identifying subjects participating in clinical trials that may exhibit a placebo response and identifying treatments for subjects with varying degrees of placebo responses. In one aspect, a method of selecting subjects to participate in a clinical trial is disclosed.
Methods and compositions for detection of targets for autoimmune disease
The present invention is directed to methods and compositions for identifying targets for induction of self-tolerance and treatment of autoimmune disease.. .
University Health Network
Unsymmetrical pyrrolobenzodiazepines-dimers for use in the treatment of proliferative and autoimmune diseases
Or a pharmaceutically acceptable salt or solvate thereof.. .
4-position substituted pyrazolopyrimidine derivative, and use thereof in drug preparation
The invention provides a new pyrazolopyrimidine derivative and a simple, efficient and low-cost preparation method thereof. The pyrazolopyrimidine derivative of the invention has good inhibitory activity for multiple kinases, has inhibitory action on multiple solid tumors, leukemia and autoimmune diseases, provides a new effective choice for preparation of kinase inhibitors, medicines for autoimmune diseases, angiogenesis inhibitors and antitumor drugs, and has good application prospect..
The present invention is directed towards a new method of synthesis of 18f-folate radiopharmaceuticals, wherein fluorine-18 is attached to a pteroate (or folate) or derivative thereof, through direct radiolabeling with 18[f]fluoride, as well as 18f-folate radiopharmaceuticals obtained by such method of synthesis and their use in diagnosis and monitoring of cancer therapy and therapy of inflammatory and autoimmune diseases.. .
Merck & Cie
And/or a salt thereof; wherein r is —oh or —op(o)(oh)2. Also disclosed are methods of using such compounds as selective agonists for g protein-coupled receptor s1p1, and pharmaceutical compositions comprising such compounds.
Disulfur bridge linkers for conjugation of a cell-binding molecule
The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of the conjugates in treatment of cancers, infections and autoimmune disorders..
Suzhou M-conj Biotech Co., Ltd
Liquid formulation comprising gm-csf neutralizing compound
The present invention relates to aqueous formulations comprising a compound neutralizing gm-csf in concentrations of at least about 20 mg/ml, a tonicity modifier and a buffer, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing gm-csf in view of long-term storage.
Compounds and treating autoimmune diseases
Wherein x and y independently are o or nr1; each r1 is independently h or c1-c6 alkyl; ring a is aryl; each r2 independently is h, alkyl, alkoxy, amide, cyano, halo, haloalkyl, hydroxyalkyl, heteroalkyl, heterocyclyl, sulfonyl, sulfonamide, or two r2 groups, taken together with the atom or atoms to which they are attached, combine to form a 4-10 membered ring system; p is 0, 1, 2, 3, or 4; r3 and r4 independently are h or c1-c6 alkyl; and r5 is halo, cyano, or c1-c6 alkyl.. .
Novel heteroaryl and heterocycle compounds, compositions and methods thereof
Disclosed are novel heteroaryl and heterocycle compounds of formula i-1, i-2 or i-3 and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of pi3k and for treating inflammatory and autoimmune diseases and cancer.. .
Hutchison Medipharma Limited
Methods of diagnosing and treating small intestinal bacterial overgrowth (sibo) and sibo-related conditions
Disclosed is a method of treating small intestinal bacterial overgrowth (sibo) or a sibo-caused condition in a human subject. Sibo-caused conditions include irritable bowel syndrome, fibromyalgia, chronic pelvic pain syndrome, chronic fatigue syndrome, depression, impaired mentation, impaired memory, halitosis, tinnitus, sugar craving, autism, attention deficit/hyperactivity disorder, drug sensitivity, an autoimmune disease, and crohn's disease.
Cedars-sinai Medical Center
Compositions for treating an inflammatory autoimmune condition
The present invention relates to a medicament comprising human tr1 cells directed to a human hsp and methods for treating an inflammatory autoimmune condition.. .
Inhibitors of bruton's tyrosine kinase
Disclosed herein are compounds that form covalent bonds with bruton's tyrosine kinase (btk). Also described are irreversible inhibitors of btk.
Stimulus releasing stress, and stress-free medical treatment method by the stimulus method
An autoimmune disease treatment method includes applying a thermal stimulus to a specific area to be stimulated at a body surface with a stimulus applying apparatus so as to bring an increase rate of blood flow to 60% or more. The blood flow is measured by a laser doppler tissue blood flow meter attached to a central part of an inner side of a wrist joint..
Methods of using chimeric receptors to identify autoimmune disease
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of graves' disease.
Diagnotic Hybrids, Inc.
Influenza virus and type 1 diabetes
Type 1 diabetes mellitus is characterized by loss of pancreatic insulin-producing beta cells, resulting in insulin deficiency. The usual cause of this beta cell loss is autoimmune destruction.
Istituto Zooprofilattico Sperimentale Delle Venezie
Anti-blood dendritic cell antigen 2 antibodies and uses thereof
Antibodies and antibody fragments that bind to bdca2 are disclosed. Also disclosed are methods of using the antibodies and antibody fragments to induce death of a plasmacytoid dendritic cell, inhibit production or secretion of inflammatory cytokines and chemokines, and treat or prevent immunological disorders such as inflammatory and autoimmune conditions..
Biogen Ma Inc.
Methods and compositions for modulating toso activity
The present invention is further directed to methods and compositions for modulating the activity of the toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble toso protein..
University Health Network
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed herein are compounds that inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases using the compounds.. .
Novel imidazopyridine derivatives as a tyrosine kinase inhibitor
Provided is a novel imidazopyridine derivative having irreversible tyrosine kinase inhibiting activities, and a pharmaceutical composition comprising the same which can be useful for prevention or treatment of inflammatory diseases, autoimmune diseases, proliferative diseases or hyperproliferative diseases, immunologically mediated diseases, cancers or tumors.. .
Hanmi Pharm. Co., Ltd.
Amine derivatives as potassium channel blockers
The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of kv1.3 channels found in t cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation..
Merck Patent Gmbh
Modulators of the retinoid-related orphan receptor gamma (ror-gamma) for use in the treatment of autoimmune and inflammatory diseases
The present invention relates to novel retinoid-related orphan receptor gamma (rorγ) modulators and their use in the treatment of diseases mediated by rorγ.. .
Glaxo Group Limited
Prodrugs of monomethyl fumarate (mmf)
The present invention relates to novel compounds for use as a medicament. In particular, the present invention relates to novel prodrugs of monomethyl fumarate (mmf) suitable as a medicament, preferably in the treatment and/or prevention of systemic diseases, autoimmune diseases, inflammatory diseases, for example multiple sclerosis and psoriasis..
Method of controlling administration of cancer antigen
The present invention is directed to mammalian bi-specific t cells and methods for using these bi-specific t cells. More specifically, the invention relates to a method of controlling administration of cancer antigen to a subject by providing bi-specific t cells that express a viral antigen t cell receptor and a cancer antigen-specific chimeric receptors and triggering their activation by also administering antigen-presenting t-cells which express viral antigen.
City Of Hope
Methods of treating pulmonary fibrosis
A method of treating ionizing radiation injury, or pulmonary fibrosis, or pulmonary hypertension due to any cause, such as idiopathic, autoimmune, or environmental, in a mammalian subject in need thereof, comprises administering the subject a gastrin-releasing peptide (grp) blocking agent or inhibitor in a treatment effective amount.. .
Novel heteroaryl and heterocycle compounds, compositions and methods
Provided are novel heteroaryl and heterocycle compounds of formula (i-1), (i-2) or (i-3) and pharmaceutical compositions comprising them, uses and methods thereof for inhibiting the activity of pi3k and for treating inflammatory and autoimmune disorders diseases and cancer.. .
Bruton's tyrosine kinase inhibitors
Disclosed herein are compounds that form covalent bonds with bruton's tyrosine kinase (btk). Methods for the preparation of the compounds are disclosed.
Novel biphenyl derivative or pharmaceutically acceptable salt thereof, and pharmaceutical composition for preventing or treating inflammatory diseases or autoimmune diseases comprising the same as active ingredient
The present invention relates to a novel biphenyl derivative or a pharmaceutically acceptable salt thereof, a pharmaceutical composition for preventing or treating inflammatory diseases or autoimmune diseases comprising the same as an active ingredient, and methods for treating inflammatory disease or autoimmune diseases with the pharmaceutical composition. Novel biphenyl derivatives according to the present invention promote the phagocytosis of macrophages and inhibit the chemotaxis to exhibit excellent inflammation terminating and anti-inflammatory effects and thus can be effectively used as therapeutic agents for inflammatory diseases or autoimmune diseases..
Extracorporeal autoimmune solution therapy (east)
A therapeutic procedure, extracorporeal autoimmune solution therapy (east), is invented for eliminating pathogenic or pathologic antibodies and immune complexes via affinity column capture, specific enzyme cleavage, and specific immune suppression/immune modulation via reinfusion of the autoantibody fab, f(ab′)2 or fc fragments back into the patients with a variety of acute or chronic autoimmune, inflammatory, and related other diseases.. .
Combination of anti-cd20 antibody and pi3 kinase selective inhibitor
Highly effective combinations of a compound of formula a (a pi3kδ selective inhibitor) and anti-cd20 antibodies are provided herein for the treatment and amelioration of pi3kδ and/or cd20 mediated diseases and disorders. In particular, the combination can be used to treat cancers and autoimmune diseases.
Ideotypically modulated pharmacoeffectors for selective cell treatment
In a method embodiment, a method includes introducing a plurality of ideotypically modulated pharmacoeffectors (imp) into a population of cells. Each imp may include a detection domain and an activation domain.
Prevotella histicola preparations and the treatment of autoimmune conditions
This document provides methods and materials related to prevotella histicola preparations. For example, prevotella histicola preparations in the form of an oral medicament or dietary supplement (e.g., a pill, tablet, capsule) are provided.
Intracellular kinase inhibitors
Intracellular kinase inhibitors and their therapeutic uses for patients with t cell malignancies, b cell malignancies, autoimmune disorders, and transplanted organs.. .
Clinical grade sodium alginate for microencapsulation of myofibroblasts isolated from wharton jelly for prevention and treatment of autoimmune and inflammatory diseases
A method for microencapsulation includes isolating myofibroblasts from wharton's jelly of a human umbilical cord. The myofibroblasts are microencapsulated using ultra-purified sodium alginate, wherein the myofibroblasts encapsulated in the sodium alginate form a three-dimensional spherical structure..