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Autoimmune

Autoimmune-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Marker sequences for diagnosing and stratifying systemic sclerosis patients
Protagen Ag
July 13, 2017 - N°20170199202

The present invention relates to methods for identifying markers for systemic sclerosis (also scleroderma; ssc) and to the markers identified with the aid of this method, which can differentiate between ssc and other autoimmune diseases on the one hand and between different ssc subgroups on the other hand. The invention also relates to panels, diagnostic devices and test kits which ...
Compositions and methods for the diagnosis of systemic autoimmune disease
Inova Diagnostics, Inc.
July 13, 2017 - N°20170199187

The present disclosure relates to the field of molecular biology and immunology. More specifically, the present disclosure provides compositions and methods for detecting anti-th/to autoantibodies in the serum of subject with a systemic autoimmune disease, such as systemic sclerosis (ssc).
Methods of using cells associated with autoimmune disease
Singapore Health Services Pte Ltd.
July 13, 2017 - N°20170199186

The present invention relates to methods of diagnosing autoimmune disease, predicting suitable treatments of autoimmune disease or identifying autoantigens of autoimmune disease using a population of immunogenic hla-dr+ t cells.
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Anti-il-17a antibodies and their use in treating autoimmune and inflammatory disorders
Novartis Ag
July 13, 2017 - N°20170198035

The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine il-17 a. The disclosure more specifically relates to specific antibodies and proteins that are il-17 a antagonists (inhibit the activities of il-17 a and il-17 af) and are capable of inhibiting il-17 a induced cytokine production in in vitro assays, ...
Novel combinations for antigen based therapy
Diamyd Medical Ab
July 13, 2017 - N°20170196949

The present invention relates to a method for prevention and/or treatment of an autoimmune disease, comprising administering a composition, said composition comprising at least one beta cell autoantigen, to a subject the subject may have a serum vitamin-d level above 50 nanomole/liter or the composition may be administered by intralymphatic injection or injection directly into a lymph node, or ...
Mth1 inhibitors for treatment of inflammatory and autoimmune conditions
Thomas Helledays Stiftelse For Medicinsk Forskning
July 13, 2017 - N°20170196873

A compound of formula (i), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.
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Autoimmune Patent Applications
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  • 462+ full patent PDF documents of Autoimmune-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Apoptosis signal-regulating kinase inhibitors
Mingsight Pharmaceuticals, Inc.
July 13, 2017 - N°20170196844

Wherein x1, x2, x3, x4, x5, x6, x7, x8, r1, r2, r3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or ...
Methods of treating autoimmune, respiratory and inflammatory disorders by inhalation of roflumilast n-oxide
Incozen Therapeutics Pvt. Ltd.
July 13, 2017 - N°20170196843

The present disclosure relates to pharmaceutical compositions useful for (and to a method of) treating autoimmune, respiratory and/or inflammatory diseases and conditions. The method involves administering to a subject in need thereof roflumilast n-oxide by inhalation. The present disclosure particularly relates to the treatment of asthma and chronic obstructive pulmonary disease (copd) by administering roflumilast n-oxide by inhalation.
Alpha1 -antitrypsin compositions and methods of treating autoimmune diseases
Beth Israel Deaconess Medical Center, Inc.
July 06, 2017 - N°20170190762

The specification provides compositions comprising chimeric proteins comprising aat conjugated to an fc region of an immunoglobulin. Methods for treating autoimmune disease, e. G., diabetes, e. G., type 1 and type 2 diabetes, are also provided.
Pyridine and pyridimine compounds as pi3k-gamma inhibitors
Incyte Corporation
July 06, 2017 - N°20170190689

The present disclosure provides compounds of formula i, or pharmaceutically acceptable salts thereof, that modulate the activity of phosphoinositide 3-kinases-gamma (pi3kγ) and are useful in the treatment of diseases related to the activity of pi3kγ including, for example, autoimmune diseases, cancer, cardiovascular diseases, and neurodegenerative diseases.
Prevotella histicola preparations and the treatment of autoimmune conditions
Mayo Foundation For Medical Education And Research
July 06, 2017 - N°20170189455

This document provides methods and materials related to prevotella histicola preparations. For example, prevotella histicola preparations in the form of an oral medicament or dietary supplement (e. G., a pill, tablet, capsule) are provided. In addition, methods and materials for using a prevotella histicola preparation provided herein as an anti-inflammatory agent are provided.
Amino compounds for treatment of complement mediated disorders
Achillion Pharmaceuticals, Inc.
July 06, 2017 - N°20170189410

Compounds, methods of use, and processes for making inhibitors of complement factor d comprising formula i, or a pharmaceutically acceptable salt or composition thereof, wherein r12 or r13 on the a group is an amino substituent (r32) are provided. The inhibitors described herein target factor d and inhibit or regulate the complement cascade at an early and essential point in ...
Use of kukoamine a and kukoamine b
The First Affiliated Hospital, Third Military Medical University, Pla
July 06, 2017 - N°20170189355

The use of kukoamine a and kukoamine b in the preparation of drugs for the prevention and treatment of sepsis and autoimmune disease is disclosed. Bacterial endotoxin/lipopolysaccaride (lps) and unmethylated dna (cpg dna) of bacteria, the major pathogen-associated molecular patterns in sepsis and autoimmune disease, are specifically targeted, while the disclosed use and directionally isolates lead compounds from traditional ...
Autoimmune Patent Pack
Download 462+ patent application PDFs
Autoimmune Patent Applications
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For professional research & prior art discovery
inventor
  • 462+ full patent PDF documents of Autoimmune-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Compositions and methods for autoimmune disease
Nodality, Inc.
June 29, 2017 - N°20170184587

Methods and compositions are described for categorizing and treating autoimmune disease, using single cell network profiling (scnp), where activation levels of one or more activatable elements are determined in single cells, with or without modulation, to categorize or determine treatment for the autoimmune disease.
Inhibitors of cyclin-dependent kinase 7 (cdk7)
Syros Pharmaceuticals, Inc.
June 29, 2017 - N°20170183355

The present invention provides novel compounds of formula (i) and formula (ii) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e. G., cancers (e. G., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and ...
Pyrrolopyrimidine compounds and their uses
Astex Therapeutics Ltd.
June 29, 2017 - N°20170183352

The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as cdk1, cdk2, cdk4, cdk5, cdk6, ...
Improved anti-nuclear antibody detection and diagnostics for systemic and non-systemic autoimmune disorders
Immco Diagnostics, Inc.
June 22, 2017 - N°20170176454

Provided are compositions that contain mammalian cells for use in detecting antibodies. The mammalian cells are modified such that they do not contain ledgf protein. The mammalian cells are immobilized on a solid substrate. The compositions can also contain mammalian cells that contain the ledgf protein. Methods for using the cell compositions in diagnostic approaches are included, as are kits ...
Autoantibody detection method, method for testing possibility of autoimmune disease contraction, autoantibody detection reagent, and ...
Osaka University
June 22, 2017 - N°20170176432

The present invention provides an autoantibody detection method that can detect an autoantibody causing an autoimmune disease with high accuracy. The autoantibody detection method of the present invention includes the steps of; causing a sample and an antigen reagent comprising a denatured protein presented by an mhc class ii molecule to come into contact with each other; and detecting a ...
Self assembling nucleic acid nanostructures
Exicure, Inc.
June 22, 2017 - N°20170175121

Stable self-assembling nucleic acid nanostructures comprising: —a plurality of oligonucleotides, —a plurality of g-quadruplex forming nucleic acids linked to the plurality of oligonucleotides, and —a plurality of g-quadruplex stabilizing domains linked to the g-quadruplex forming nucleic acids. The nucleic acid nanostructures are suitable for use as agonists or antagonists of nucleic acid interacting complexes, such as toll-like ...
Bi-terminal pegylated integrin-binding peptides and methods of use thereof
The Regents Of The University Of California
June 22, 2017 - N°20170174723

The present invention provides bi-terminal pegylated peptide conjugates that target an integrin such as αvβ6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e. G., covalently attached to one of the peg moieties. The peptide conjugates of the present ...
Quinoxaline compounds and uses thereof
Millennium Pharmaceuticals, Inc.
June 22, 2017 - N°20170174704

This invention provides compounds of formula i and subsets thereof: wherein t, j, r, r4, rq, o, ra, and rb and subsets thereof are as described in the specification. The compounds are inhibitors of nampt and are thus useful for treating cancer, inflammatory conditions, or t-cell mediated autoimmune disease.
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