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This page is updated frequently with new Autoimmune-related patent applications. Subscribe to the Autoimmune RSS feed to automatically get the update: related Autoimmune RSS feeds. RSS updates for this page: Autoimmune RSS RSS



Date/App# patent app List of recent Autoimmune-related patents
08/20/15
20150232552 
 Antibodies that bind il-23 patent thumbnailAntibodies that bind il-23
The present invention provides an antibody that binds to the p19 subunit of human il-23 and is characterized as having high affinity, selective, and neutralizing properties. The antibody is useful in the treatment or prevention of an autoimmune or inflammatory condition selected from the group consisting of consisting of multiple sclerosis, rheumatoid arthritis, psoriasis, inflammatory bowel diseases, ankylosing spondylitis, graft-versus-host disease, lupus and metabolic syndrome.
Eli Lilly And Company


08/20/15
20150232521 
 Peptides and methods for inducing cell death patent thumbnailPeptides and methods for inducing cell death
The invention provide isolated peptides, protides and conjugates having novel peptide sequences which are able to induce antimicrobial, anti-cancer, anti-inflammatory, anti-proliferative or programmed cell death activity. The invention also provides a method of inducing programmed cell death in a cell by contacting the cell with an isolated peptide, protide or conjugate described herein.
Los Angeles Biomedical Research Institute At Harbor-ucla Medical Center


08/20/15
20150232418 
 Hydroxy-substituted amino and ammonium derivatives and their medical use patent thumbnailHydroxy-substituted amino and ammonium derivatives and their medical use
The present invention relates to hydroxy-substituted amino and ammonium derivatives, in particular the compounds of formula (1) or (2), and their medical use, including their use in the treatment, prevention or amelioration of an inflammatory, autoimmune and/or allergic disorder, or a proliferative, neoplastic or dysplastic disease or disorder.. .
Glycoregimmune, Inc.


08/20/15
20150231281 
 Inflammation imaging and therapy patent thumbnailInflammation imaging and therapy
An imaging agent comprising a conjugate of an oligosaccharide moiety with an imaging moiety. The oligosaccharide is lewis a or lewis b or a mimetic thereof, or a pharmaceutically acceptable salt or pegylated form of lewis a or lewis b or its mimetics.
Isis Innovation Limited


08/20/15
20150231234 
 Use of anti-cd1 antibodies for the modulation of immune responses patent thumbnailUse of anti-cd1 antibodies for the modulation of immune responses
The invention provides methods for the administration of an anti-cd1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.. .
Beth Israel Deaconess Medical Center, Inc.


08/20/15
20150231212 
 St6gal-1 mediated modulation of hematopoiesis patent thumbnailSt6gal-1 mediated modulation of hematopoiesis
Provided are methods for reducing inflammation and allergic reactions and for reducing the severity of autoimmune disorders. The method involve administering to an individual a composition that contains recombinant α2,6-sialyltransferase (st6gal-1).
Health Research, Inc.


08/20/15
20150231195 
 Competitive inhibitors of invariant chain expression and/or ectopic clip binding patent thumbnailCompetitive inhibitors of invariant chain expression and/or ectopic clip binding
The invention relates to methods for modulating the immune function through targeting of clip molecules. The result is wide range of new therapeutic regimens for treating, inhibiting the development of, or otherwise dealing with, a multitude of illnesses and conditions, including autoimmune disease, cancer, alzheimer's disease, allergic disease, transplant and cell graft rejection, hiv infection and other viral, bacterial, and parasitic infection, and aids.
Regents Of The University Of Colorado, A Body Corporate


08/13/15
20150225453 
 Method of producing fr901228 patent thumbnailMethod of producing fr901228
Depsipeptides and congeners thereof are disclosed having structure (i), wherein m, n, p, q, x, r1, r2 and r3 are as defined herein. These compounds, including fr901228, have activity as, for example, immunosuppressants, as well as for the prevention or treatment of patients suffering or at risk of suffering from inflammatory, autoimmune or immune system-related diseases including graft-versus-host disease and enhancement of graft/tissue survival following transplant.
Astellas Pharma Inc.


08/13/15
20150225438 
 Suprametallogels and uses thereof patent thumbnailSuprametallogels and uses thereof
The disclosure provides nanostructures (e.g., nanospheres and nano-paddlewheels) formed through transition metal-ligand (e.g., pd(ii)-, ni(ii)-, or fe(ii)-ligand of formula (a)) coordination and junction self-assembly. The disclosure also provides supramolecular complexes that include the nanostructures connected by divalent linkers y.
Massachusetts Institute Of Technology


08/13/15
20150225411 
 Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors patent thumbnailAzetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
The present invention provides azetidinyl phenyl, pyridyl, or pyrazinyl carboxamide derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase (jaks) and are useful in the treatment of diseases related to the activity of jak including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.. .
Incyte Corporation


08/13/15
20150225398 

Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders


Useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.. .

08/13/15
20150224199 

Pharmaceutical compositions for the treatment of inflammatory disorders


Useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.. .

08/13/15
20150224146 

Cell populations having immunoregulatory activity, isolation and uses


The present invention provides a population of connective tissue derived cells that respond to interferon-gamma (ifn-γ) by expressing indolamine-2,3-dioxygenase (ido) for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to, autoimmune diseases, inflammatory disorders, and immunologically mediated diseases including rejection of transplanted organs and tissues.. .
Consejo Superior De Investigaciones Cientificas


08/13/15
20150224141 

Methods of using small compounds to enhance myeloid derived suppressor cell function for treating autoimmune diseases


Methods for enhancing the suppressive function of myeloid derived suppressor cells (mdscs) for the treatment of autoimmune diseases using small compounds are disclosed. In certain aspects, the small compounds are glatiramer acetate and mitogen activated protein (map) kinase inhibitors.
Icahn School Of Medicine At Mount Sinai


08/06/15
20150219664 

Methods and compositions for diagnosis of inflammatory liver disease


The present disclosure provides methods and compositions that find use in facilitating a diagnosis of inflammatory liver disease in a subject. The methods and compositions generally involve detection of eotaxin-3 (e3) levels, either alone or with levels of eotaxin-1 (e1), and optionally, with levels of ccl22 and, further optionally, with levels of il15.
Medizinische Hochschule Hannover


08/06/15
20150218563 

Compositions and methods for modulation of rorgammat functions


The present invention relates to expression of rorγt in cells and tissues and the effect of expression of this gene on proliferation of specific immune cells and in promotion of immune cell aggregates and in induction of il17 producing cells. Furthermore, the invention relates to methods and agents that may decrease function of the gene product (the protein) or expression of this gene in individuals experiencing an inflammatory condition, an autoimmune disease or a food allergy, or any other condition whereby it is desirable to inhibit an immune response.

08/06/15
20150218260 

Interleukin-2 fusion proteins and uses thereof


The present invention generally relates to fusion proteins of immunoglobulins and interleukin-2 (il-2). More particularly, the invention concerns fusion proteins of immunoglobulins and mutant il-2 that exhibit improved properties for use as therapeutic agents, e.g.
Hoffman-la Roche Inc.


08/06/15
20150218239 

Fcrn antagonists and methods of use


Provided are novel fcrn antagonist compositions comprising a variant fc region that binds specifically to fcrn with increased affinity and reduced ph dependence relative to the native fc region. Also provided are fcrn antagonists with enhanced cd16 binding affinity.
The Board Of Regents Of The University Of Texas System


08/06/15
20150218236 

Immunomodulatory proteins


A method for treatment of a mammalian subject for an autoimmune or inflammatory disease, the method comprising: administering to the mammalian subject an effective amount of a polymeric protein comprising five, six or seven polypeptide monomer units; wherein each polypeptide monomer unit comprises an fc receptor binding portion comprising two immunoglobulin g heavy chain constant regions; wherein each immunoglobulin g heavy chain constant region comprises a cysteine residue which is linked via a disulfide bond to a cysteine residue of an immunoglobulin g heavy chain constant region of an adjacent polypeptide monomer unit; wherein the polymeric protein does not comprise a further immunomodulatory portion; or an antigen portion that causes antigen-specific immunosuppression when administered to the mammalian subject.. .
Liverpool School Of Tropical Medicine


08/06/15
20150218199 

Hydroxylated krn7000 analogue and use thereof


Wherein r1 is a hydrogen atom or a hydroxyl group; two r2 are the same or different and each is a hydrogen atom or a hydroxyl group; r3 is a hydrocarbon group having 8-14 carbon atoms, which optionally has substituent(s); and r4 is a hydrocarbon group having 18-24 carbon atoms, which optionally has substituent(s), or a salt thereof. The invention also provides a method of treating an autoimmune disease or suppressing immunity by administering the aforementioned compound or a salt thereof to a patient in need thereof..

08/06/15
20150218160 

Dihydropyrrolopyridine inhibitors of ror-gamma


Pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful in the treatment of diseases and disorders mediated by rorγ. Also provided are pharmaceutical compositions comprising the novel compounds of formula (i) and methods for their use in treating one or more inflammatory, metabolic, autoimmune and other diseases or disorders..

08/06/15
20150218126 

Crystalline forms of thalidomide and processes for their preparation


The present invention related to crystalline forms of thalidomide having a high polymorphic purity and to processes for their preparation. The present invention also relates to pharmaceutical preparations comprising the crystalline forms for the treatment of patients suffering from autoimmune, inflammatory or angiogenic disorders..
Generics [uk] Limited


08/06/15
20150216971 

Methods for treating gi syndrome and graft versus host disease


It has been discovered that administering therapeutically effective amounts of an antibiotic that kills gram-negative bacteria, together with an anti-ceramide antibody or anti-ceramide mimetic, treats and prevents an array of diseases mediated by cytolytic t lymphocyte (ctl)-induced killing and/or by damage to endothelial microvasculature, including radiation gi syndrome, cgvhd disease, inflammatory diseases and autoimmune diseases.. .
Sloan Kettering Institute For Cancer Research


08/06/15
20150216900 

Enhancement of allogeneic hematopoietic stem cell transplantation


Methods and compositions are provided to augment the conversion of mixed hematopoietic cell chimerism to complete donor cell chimerism following allogeneic hematopoietic cell transplantation (hct), where such transplantation may be utilized for treatment of cancer such as leukemia and lymphoma or for other conditions requiring reconstitution of the hematopoietic system, e.g. Treatment of anemias, thalassemias, autoimmune conditions, and the like.
The Board Of Trustees Of The Leland Stanford Junior University


08/06/15
20150216876 

Method for treating inflammatory conditions


A method for treating an autoimmune disease in a subject includes administering to the subject a therapeutically effective amount of an agent comprising an imidazole, an estrogen receptor agonist, or pharmaceutically acceptable salts thereof.. .
Novelmed Therapeutics, Inc.


07/30/15
20150210982 

Isolation and use of human regulatory t cells


The present invention provides a new method for isolating and enriching human regulatory t cells. The enriched cells are useful in the treatment of autoimmune disease..
Biogen Idec Ma Inc.


07/30/15
20150210703 

Imidazopyridazine jak3 inhibitors and their use for the treatment of inflammatory and autoimmune diseases


The present invention provides compounds of formula (i) and pharmaceutically acceptable salts thereof. The formula i compounds inhibit tyrosine kinase activity of jak3, thereby making them useful for the treatment of inflammatory and autoimmune diseases..
Bristol-myers Squibb Company


07/30/15
20150209410 

Compositions and methods relating to the treatment of diseases


A method is provided for the treatment and/or prophylaxis of a condition where an enhancement of a th1-mediated immune response and suppression of a th2/th17-mediated immune response are desired. The method comprises the step of administering to a subject in need thereof a therapeutically effective amount of at least one interferon alpha subtype selected from ifn-α10, ifn-α14, and a hybrid thereof.
Alfacyte, Ltd.


07/30/15
20150209348 

Histamine 4 receptor partial agonists, inverse agonists or antagonists for use in treating non-autoimmune uveitis


The invention provides a compound which is a histamine 4 receptor antagonist, partial agonist or inverse agonist, for use in the treatment of non-autoimmune uveitis. The compound preferably has a structural core comprising a substituted pyrimidine group, such as an aminopyrimidine, diaminopyrimidine or triaminopyrimidine group, a thienopyrimidine, a furopyrimidine, a benzimidazole, an aryl or heteroaryl-fused pyrimidine, an indole, a bicyclic heteroaryl-substituted imidazole or a quinazoline group..
Ucl Business Plc


07/23/15
20150204871 

Automated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases


A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.. .
Hycor Biomedical, Inc.


07/23/15
20150204867 

Automated immunoanalyzer system for performing diagnostic assays for autoimmune and infectious diseases


A quantitative method for diagnosing an autoimmune disease or an infectious disease comprising performing an automated diagnostic assay, comprising: incubating a capture reagent with a streptavidin-coated medium to form a solid phase complex, wherein the capture reagent is a biotinylated autoantigen or infectious disease antigen; washing the solid phase complex to remove excess capture reagent; incubating the solid phase complex with a serum sample to form an immune complex; washing the immune complex to remove any unbound sample; incubating the immune complex with a conjugate to create an immune-conjugate complex; washing the immune-conjugate complex to remove any unbound conjugate; introducing a substrate capable of generating a quantifiable response; and calibrating the response generated from introducing the substrate.. .
Hycor Biomedical, Inc.


07/23/15
20150203851 

Inhibitors of bromodomain-containing protein pcaf for the treatment of autoimmune and inflammatory diseases or for the treatment of cancer


A method of treating autoimmune and inflammatory diseases or conditions or cancer in a mammal, such as a human, which comprises the administration of an inhibitor of the bromodomain-containing protein pcaf.. .
Glaxo Group Limited


07/23/15
20150203847 

Chemical modifications of monomers and oligonucleotides with cycloaddition


In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression..

07/23/15
20150203820 

Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof


The present invention relates to methods of generating and expanding hitman embryonic stem eel! derived mesenchymal-like stem/siromal cells. These hes-mscs are characterized at least in part by the low level of expression of il-6.
Imstem Biotechnology, Inc.


07/23/15
20150203579 

Human antibodies to pd-1


The present invention provides antibodies that bind to the t-cell co-inhibitor programmed death-1 (pd-1) protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that bind to pd-1.
Regeneron Pharmaceuticals, Inc.


07/23/15
20150203560 

Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases


The field of the present invention relates to genetically engineered fusion molecules, methods of making said fusion molecules, and uses thereof for treatment of autoimmune diseases. More specifically, the present invention provides novel genetically engineered fusion molecules comprising an interferon (ifn) molecule attached to an antibody (ab) which targets an antigen which is differentially expressed or up-regulated on activated t cells as compared to resting t cells, wherein the fusion molecule when contacted to an activated t cell results in induced apoptosis and programmed cell death or impairment of functions of said activated t cell..
Immungene Inc.


07/23/15
20150203556 

Compositions and methods for modulation of il-20 family cytokine activity


Provided herein are compositions comprising one or more agents that inhibit or reduce the activity of il-20. Optionally, the agents further inhibit or reduce the activity of il-24.
The Uab Research Foundation


07/23/15
20150203537 

Inhibition of gliadin peptides


Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining modulators of biological barrier permeability and for peptide translocation across biological barriers are provided.
Alba Therapeutics Corporation


07/23/15
20150203486 

Imidazopyridine derivatives as modulators of tnf activity


A series of imidazo[1,2-a]pyridine derivatives of formula (i), being potent modulators of human tnfa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. .
Ucb Biopharma Sprl A Corporation


07/23/15
20150203483 

2,3-benzodiazepines


In which r1a, r1b, r1c, r2, r3, r4, r5, a and x have the meanings given in the description, intermediates for preparing the compounds according to the invention, pharmaceutical compositions comprising the compounds according to the invention and their prophylactic and therapeutic use for hyperproliferative disorders, in particular for tumour disorders. Also described is the use of bet protein inhibitors for benign hyperplasias, atherosclerotic disorders, sepsis, autoimmune disorders, vascular disorders, viral infections, for neurodegenerative disorders, for inflammatory disorders, for atherosclerotic disorders and for the control of male fertility..

07/23/15
20150203455 

Novel compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders


Wherein cy, r1, l1, r3, r4, r5, la, and ra are as defined herein. Novel benzimidazoles according to formula i, able to inhibit jak are disclosed, these compounds may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, allergic diseases, inflammatory diseases, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or hypersecretion of interferons..



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Autoimmune topics: Autoimmune, Immune Disease, Autoimmune Disease, Immune Diseases, Autoimmune Diseases, Transplant, Immune Disorder, Autoimmune Disorder, Autoimmune Disorders, Infectious, Infectious Disease, Inflammatory Disease, Type 1 Diabetes, Proliferative Disorder, Recurrence

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This listing is a sample listing of patent applications related to Autoimmune for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Autoimmune with additional patents listed. Browse our RSS directory or Search for other possible listings.


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