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Autoimmune

Autoimmune-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Markers of alzheimers disease
Immunoclin Ltd.
January 11, 2018 - N°20180010182

The use of markers that participate in inflammatory processes and are associated cytokines in the diagnosis, treatment or prophylaxis of diseases is disclosed. Specifically, cytokines are used to diagnose or treat non-neoplastic or non-leukaemic diseases such as autoimmune diseases or neurodegenerative disorders by the process of taking a dna bearing sample from a subject animal and analysing the sample to ...
Mesenchymal-like stem cells derived from human embryonic stem cells, methods and uses thereof
Imstem Biotechnology, Inc.
January 11, 2018 - N°20180010098

The present invention relates to methods of generating and expanding hitman embryonic stem cell derived mesenchymal-like stem/stromal cells. These hes-mscs are characterized at least in part by the low level of expression of il-6. These cells are useful for the prevention and treatment of t cell related autoimmune disease, especially multiple sclerosis, as well as for delivering agents across ...
Methods for the treatment of disease using immunoglobulins having fc regions with altered affinities for ...
Macrogenics, Inc.
January 11, 2018 - N°20180009902

The present invention relates to methods of treating or preventing cancer and other diseases using molecules, particularly polypeptides, more particularly immunoglobulins (e. G., antibodies), comprising a variant fc region, wherein said variant fc region comprises at least one amino acid modification relative to a wild-type fc region, which variant fc region binds an fcγr that activates a ...
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Heterocyclic compounds and use thereof
National Health Research Institutes
January 11, 2018 - N°20180009786

Heterocyclic compounds of formula (i) shown herein. Also disclosed are pharmaceutical compositions containing the heterocyclic compounds and methods of using the heterocyclic compounds to mobilize hematopoietic stem cells and endothelial progenitor cells into the peripheral circulation. Further provided are methods for treating tissue injury, cancer, inflammatory disease, and autoimmune disease with the heterocyclic compounds.
Quinazoline and quinoline compounds and uses thereof
Millennium Pharmaceuticals, Inc.
January 11, 2018 - N°20180009784

This invention provides compounds of formula (i) or a pharmaceutically acceptable salt thereof, wherein t, j, r, r4, rq, o, ra, w and rb and subsets thereof are as described in the specification. The compounds are inhibitors of nampt and are thus useful for treating cancer, inflammatory conditions, and/or t-cell mediated autoimmune disease.
Inhibitors of trka kinase
Gvk Biosciences Private Limited
January 11, 2018 - N°20180009781

The present invention is directed to the compounds of formula i which are inhibitors of tropomyosin-related kinase a (trka): formula (i) or steroisomers, tautomers or a pharmaceutically acceptable salts, metabolites, isotopes, solvates or prodrugs thereof, wherein, ra, rb, rc, rd, r1, r2, l and het-ar are as defined herein. These compounds can be used for the preventive and/or therapeutic ...
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Autoimmune Patent Applications
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Covalent inhibitors of cdk-7
Augusta University Research Institute, Inc.
January 11, 2018 - N°20180008604

Wherein r0, r1, r2, r3, r4, r5, and l are defined herein. Also disclosed is a method for treating a neoplastic disease, autoimmune disease, and inflammatory disorder with these compounds.
2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof
Guangzhou Institutes Of Biomediciene And Health, Chinese Academy Of Sciences
January 11, 2018 - N°20180008574

The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the bet bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, ...
Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders
Guangzhou Institutes Of Biomediciene And Health, Chinese Academy Of Sciences
January 04, 2018 - N°20180007043

Useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.
Method of assessing rheumatoid arthritis by measuring anti-ccp and anti-pik3cd
Roche Diagnostics Operations, Inc.
January 04, 2018 - N°20180003710

The present invention relates to a method aiding in the assessment of rheumatoid arthritis (“ra”). The method is used in assessing ra in vitro. It is practiced by analyzing biochemical markers, comprising measuring the concentration of anti-ccp and anti-pik3cd and correlating the concentrations determined to the absence or presence of ra. The invention also relates ...
C-rel-specific sirna and its use for preventing and treating autoimmune psoriasis
The Trustees Of The University Of Pennsylvania
January 04, 2018 - N°20180002698

The present invention provides a c-rel-specific sirna and its use for preventing and treating autoimmune psoriasis. In particular, the c-rel-specific sirnas have sequences as shown in seq id nos. 1-2 or seq id nos. 3-4. In the present invention, small interfering rna (sirel) specific to c-rel are employed to inhibit c-rel biosynthesis, and prevent and treat autoimmune psoriasis by inhibiting ...
Cyclic dinucleotides useful for the treatment of inter alia cancer
The Trustees Of The University Of Pennsylvania
January 04, 2018 - N°20180002369

Or a pharmaceutically acceptable salt and tautomers thereof, compositions, combinations and medicaments containing said compounds and processes for their preparation. The invention also relates to the use of said compounds, combinations, compositions and medicaments, in the treatment of diseases and conditions in which modulation of sting (stimulator of interferon genes) is beneficial, for example inflammation, allergic and autoimmune diseases, infectious ...
Tricyclic sulfones as ror gamma modulators
The Trustees Of The University Of Pennsylvania
January 04, 2018 - N°20180002358

Or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating rorγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit ...
Autoimmune Patent Pack
Download 462+ patent application PDFs
Autoimmune Patent Applications
Download 462+ Autoimmune-related PDFs
For professional research & prior art discovery
inventor
  • 462+ full patent PDF documents of Autoimmune-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Compositions containing combinations of bioactive molecules derived from microbiota for treatment of disease
Riken
January 04, 2018 - N°20180000921

Compositions consisting of bioactive molecules derived from the microbiota of a mammal are provided herein. When administered orally with a colonic delivery system, the compositions are useful for the prophylaxis and treatment of diseases, in particular inflammatory, autoimmune and infectious diseases. The compositions comprise combinations of small molecules and bacterial antigens formulated in colonic delivery systems. Use of the compositions ...
Systems andmethods to improve organor tissue function andorganor tissue transplant longevity
Proterris, Inc.
January 04, 2018 - N°20180000859

The present invention provides for systems and methods for inhaled co therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological ...
Novel compound useful for the treatment of degenerative and inflammatory diseases
Galapagos Nv
January 04, 2018 - N°20180000831

A novel compound able to inhibit jak is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/...
[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
Galapagos Nv
January 04, 2018 - N°20180000790

Or a salt thereof, wherein r1, r2, r3, r4, r5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.
Cyclic ureas as inhibitors of rock
Bristol-myers Squibb Company
January 04, 2018 - N°20180000788

The present invention provides compounds of formula (i): or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective rock inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.
Intestinal fxr agonism enhances glp-1 signaling to restore pancreatic beta cell functions
Salk Institute For Biological Studies
January 04, 2018 - N°20180000768

Disclosed are embodiments of a method of treating or preventing latent autoimmune diabetes of adults (lada) in a subject. Such embodiments include administering to a subject (e. G., via the gastrointestinal tract) a therapeutically effective amount of one or farnesoid x receptor (fxr) agonist compounds, thereby activating fxr receptors in the intestines, and treating or preventing latent autoimmune diabetes of ...
Interferon alpha antibodies and their uses
E. R. Squibb & Sons, L.l.c.
December 28, 2017 - N°20170369568

The present invention provides isolated anti-interferon alpha monoclonal antibodies, particularly human monoclonal antibodies, that inhibit the biological activity of multiple interferon (ifn) alpha subtypes but do not substantially inhibit the biological activity of ifn alpha 21 or the biological activity of either ifn beta or ifn omega. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also ...
Cyclic compounds and uses thereof
Karyopharm Therapeutics Inc.
December 28, 2017 - N°20170369470

The invention generally relates to substituted benzothiophenyl, substituted benzothiazolyl, substituted indolyl and substituted benzoimidazolyl compounds and, more particularly, to a compound represented by structural formula i: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of structural formula i, or a pharmaceutically acceptable ...
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