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Autoimmune patents



      
           
This page is updated frequently with new Autoimmune-related patents. Subscribe to the Autoimmune RSS feed to automatically get the update: related Autoimmune RSS feeds.

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Date/App# patent app List of recent Autoimmune-related patents
04/17/14
20140107194
 Compounds for use in the treatment of immune related inflammatory disease patent thumbnailnew patent Compounds for use in the treatment of immune related inflammatory disease
Compounds particularly for use in an autoimmune inflammatory disease and especially the treatment of inflammatory bowel disease have the formula: wherein r is selected from one or more of the same or different of hydrogen, hydroxyl, optionally substituted alkyl, optionally substituted aryl, alkoxy, aryloxy, thiol, and optionally substituted amino, and wherein r1 is selected from one or more of the same or different of hydrogen, acetyl, optionally substituted alkyl, optionally substituted aryl, and an amino acid selected from leucine, valine, isoleucine, and glycine.. .
04/17/14
20140106987
 Biomarkers for autoimmune liver diseases and uses thereof patent thumbnailnew patent Biomarkers for autoimmune liver diseases and uses thereof
The present invention relates to a method for diagnosis or prognosis of liver autoimmune diseases by means of detecting specific biomarkers in biological samples. The invention refers also to a method of monitoring an autoimmune liver disease pathology status after treatment with surgery and/or therapy in a subject with autoimmune liver disease, to kits and microarrays to perform said methods..
04/17/14
20140105972
 Prevotella histicola preparations and the treatment of autoimmune conditions patent thumbnailnew patent Prevotella histicola preparations and the treatment of autoimmune conditions
This document provides methods and materials related to prevotella histicola preparations. For example, prevotella histicola preparations in the form of an oral medicament or dietary supplement (e.g., a pill, tablet, capsule) are provided.
04/17/14
20140105913
 Immunoglobulin constant region fc receptor binding agents patent thumbnailnew patent Immunoglobulin constant region fc receptor binding agents
Ivig replacement compounds are derived from recombinant and/or biochemical creation of immunologically active biomimetic(s). These replacement compounds are then screened in vitro to assess each replacements compound's efficiency at modulating immune function.
04/17/14
20140105861
 Compositions and methods for treating endocrine, gastrointestinal or autoimmune disorders patent thumbnailnew patent Compositions and methods for treating endocrine, gastrointestinal or autoimmune disorders
Recombinant cells and methods are provided that relate to the use of isolated, engineered recombinant cells to directly or indirectly treat diseases or disorders in a mammalian host such as endocrine, gastrointestinal or autoimmune disorders. A recombinant cell is provided that comprises a signal sequence and a promoter, wherein: the signal sequence is capable of regulating signal-dependent expression of a target nucleic acid in a host or is capable of regulating signal-dependent expression of a target nucleic acid in response to an environmental stimulus, the cell is derived from an enteric or a commensal bacterium, and the target nucleic acid encodes a mammalian factor that promotes normal functioning of a physiological process in the host or is effective in preventing onset, establishment, or spread of a non-infectious disease in the host.
04/10/14
20140100234
 Quinoline derivatives as pi3 kinase inhibitors patent thumbnailQuinoline derivatives as pi3 kinase inhibitors
Invented is a method of inhibiting the activity/function of pi3 kinases using quinoline derivatives. Also invented is a method of treating one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries by the administration of quinoline derivatives..
04/10/14
20140100220
 Novel compound useful for the treatment of degenerative and inflammatory diseases patent thumbnailNovel compound useful for the treatment of degenerative and inflammatory diseases
A novel compound able to inhibit jak is disclosed, this compound may be prepared as a pharmaceutical composition, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune diseases, proliferative diseases, transplantation rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6.. .
04/10/14
20140100209
 Tgr5 modulators and methods of use thereof patent thumbnailTgr5 modulators and methods of use thereof
Or a salt, solvate, hydrate, or prodrug thereof. The compounds of formula a are tgr5 modulators useful for the treatment of various diseases, including metabolic disease, inflammatory disease, liver disease, autoimmune disease, cardiac disease, kidney disease, cancer, and gastrointestinal disease..
04/10/14
20140099708
 Anti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders patent thumbnailAnti-il12rbeta1 antibodies and their use in treating autoimmune and inflammatory disorders
The present invention relates to antibodies that specifically bind to il12rβ1, the non-signal transducing chain of both the heterodimeric il12 and il23 receptors. The invention more specifically relates to specific antibodies that are il12 and il23 receptor antagonists capable of inhibiting il12/il18 induced ifnγ production of blood cells and compositions and methods of use for said antibodies to treat pathological disorders that can be treated by inhibiting ifnγ production, il12 and/il23 signaling, such as rheumatoid arthritis, psoriasis or inflammatory bowel diseases or other autoimmune and inflammatory disorders..
04/10/14
20140099707
 Antibody polypeptides that antagonize cd40l patent thumbnailAntibody polypeptides that antagonize cd40l
Antibody polypeptides that specifically bind human cd40l are provided. The antibody polypeptides do not activate platelets.
04/10/14
20140099648
Mitochondrial nucleic acid as a marker for autoimmune and autoinflammatory diseases
The present invention relates to a method for increasing the diagnostic likelihood of the presence or absence of, or monitoring the progression or activity of an inflammatory autoimmune disease (aid), comprising detecting mitochondrial na (e.g. Mtdna) in a sample from an individual suffering from the aid or suspected of suffering from the aid..
04/10/14
20140099318
Cd3-binding molecules capable of binding to human and non-human cd3
Cd3-binding molecules capable of binding to human and non-human cd3, and in particular to such molecules that are cross-reactive with cd3 of a non-human mammal (e.g., a cynomolgus monkey) are presented. Uses of such antibodies and antigen-binding fragments in the treatment of cancer, autoimmune and/or inflammatory diseases and other conditions are presented..
04/10/14
20140099317
Antibody polypeptides that antagonize cd40
Antibody polypeptides that specifically bind a novel epitope of human cd40 are provided. The antibody polypeptides do not exhibit cd40 agonist activity.
04/03/14
20140094504
Human toll-like receptor inhibitors and methods of use thereof
Provided herein are human toll-like receptor (tlr)-inhibitors and methods for use in individuals having an autoimmune disease or an inflammatory disorder. The tlr inhibitors of the present disclosure are polynucleotides comprising an inhibitory motif for one or more of tlr7, tlr8 and tlr9..
04/03/14
20140094471
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-2 protein.. .
04/03/14
20140094425
Methods for transdifferentiation of body tissues
The invention relates to methods for transdifferentiation of body tissues which can be used to generate specific cell types needed for regenerating organs or body parts, following cellular degeneration, injury or amputation. The present invention also describes the use of tissue transdifferentiation for treating cancer and autoimmune diseases..
04/03/14
20140093521
Therapeutic dll4 binding proteins
Improved dll4 binding proteins are described, including antibodies, cdr-grafted antibodies, human antibodies, and dll4 binding fragments thereof, proteins that bind dll4 with high affinity, and dll4 binding proteins that neutralize dll4 activity. The dll4 binding proteins are useful for treating or preventing cancers and tumors and especially for treating or preventing tumor angiogenesis, and/or other angiogenesis-dependent diseases such as ocular neovascularization, or angiogenesis-independent diseases characterized by aberrant dll4 expression or activity such as autoimmune disorders including multiple sclerosis..
04/03/14
20140093509
Screening method for the identification of agents capable of activating cd4+cd25+ regulatory t-cells through interactions with the hiv-1 gp120 binding site on cd4
The present invention relates specific activation of a regulatory t cell via a specific cd4 epitope and uses thereof, e.g. For the treatment of an autoimmune disease or an allergy or asthma or graft rejection or tolerance induction..
04/03/14
20140093493
Method and formulation for reducing aggregation of a macromolecule under physiological conditions
The invention provides a method for reducing aggregation and inhibiting flocculation of a macromolecule, such as a protein, under physiological conditions, by the addition of certain cyclodextrins (cds). The invention also provides a method to minimize inflammation at the injection site during subcutaneous administration of a macromolecule and pharmaceutical formulations for such administration.
03/27/14
20140088109
N-((1r,2s,5r)-5-(tert-butylamino)-2-((s)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes
Or a pharmaceutically acceptable salt, solvate or prodrug, thereof, having unexpected dual ccr-2 and ccr-5 receptor activity. Crystalline forms, metabolites, pharmaceutical compositions containing the same and methods of using the same as agents for the treatment of inflammatory diseases, allergic, autoimmune, metabolic, cancer and/or cardiovascular diseases are also disclosed.
03/27/14
20140088106
Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
Disclosed are compounds which inhibit the activity of anti-apoptotic bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic bcl-2 protein.. .
03/27/14
20140088085
Substituted benzoazepines as toll-like receptor modulators
Provided are compositions and methods useful for modulation of signaling through the toll-like receptors tlr7 and/or tlr8. The compositions and methods have use in treating or preventing disease, including cancer, autoimmune disease, fibrotic disease, cardiovascular disease, infectious disease, inflammatory disorder, graft rejection, or graft-versus-host disease..
03/27/14
20140088052
Chalcone derivatives as nrf2 activators
Compounds and methods for treating or preventing a disease, disorder or condition associated with an nrf2-regulated pathway, including those associated with an autoimmune disease, comorbidity associated with diabetes, such as retinopathy and nephropathy, bone marrow transplant for leukemia and related cancers, bone marrow deficiencies, inborn errors of metabolism, and other immune disorders, oxidative stress, respiratory infection, ischemia, neurodegenerative disorders, radiation injury, neutropenia caused by chemotherapy, autoimmunity, and congenital neutropenic disorders, and for restoring a corticosteroid responsiveness, in a subject are provided.. .
03/27/14
20140088016
Macrocyclic therapeutic agents and methods of treatment
The instant invention describes macrocyclic compounds having therapeutic activity, and the mechanism and methods of treating disorders such as autoimmune diseases, inflammation, and cancer, tumors and cell proliferation related disorders.. .
03/27/14
20140087422
Nucleic acids related to fusion proteins
The present invention concerns a family of nucleic acids, polypeptides and cloning vectors which direct expression of fusion proteins that can mimic aggregated igg (aig) and immune complex function with respect to their interactions with fcγr and which allow for the inclusion and targeting of a second protein domain to cells expressing fcγr. This was accomplished by expressing multiple linear copies of the hinge and ch2 domains (hch2) of human igg1 fused to the framework region of human igg1.
03/27/14
20140086950
Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use
The present disclosure relates generally to therapeutic compositions comprising recombinant bacteria. Further, the disclosure elaborates upon methods of utilizing the taught therapeutic compositions to treat autoimmune and inflammatory disease.
03/27/14
20140086928
Antigenic gm-csf peptides and antibodies to gm-csf
Hybridoma lines that secrete human monoclonal antibodies with high binding specificity and biological activity, particularly neutralizing activity against granulocyte-macrophage colony stimulating factor, and methods of generating the hybridoma lines are provided. Target antigens and epitopes are also provided.
03/27/14
20140086903
Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof
The present disclosure provides a humanized anti-cd37 small modular immunopharmaceutical (smip) molecule, as well as synergistic combination therapies of cd37-specific binding molecules (such as anti-cd37 smip proteins or antibodies) with bifunctional chemotherapeutics (such as bendamustine) that can be administered concurrently or sequentially, for use in treating or preventing b-cell related autoimmune, inflammatory, or hyperproliferative diseases.. .
03/27/14
20140086895
Methods and pharmaceutical compositions for the treatment of autoimmune diseases
The present invention relates to methods and pharmaceutical compositions for the treatment of autoimmune diseases, especially rheumatoid arthritis. More particularly, the present invention relates to an a-enolase polypeptide for use in the prophylactic treatment of an autoimmune disease in a subject in need thereof..
03/27/14
20140086839
Quinolone analogs for treating autoimmune diseases
Provided are methods of treating autoimmune diseases by administering to the subject a therapeutically effective amount of a quinolone compound such as 2-(4-methyl-1,4-diazepan-1-yl)-n-((5-methylpyrazin-2-yl)methyl)-5-oxo-5h-benzo[4,5]thiazolo[3,2-a][1,8]naphthyridine-6-carboxamide (cx-5461). Also provided are methods of monitoring efficiency of treatment of the quinolone compound by determining the expression level of at least one gene of the rna polymerase i pathway..
03/20/14
20140080872
Use of phospho-akt as a biomarker of drug response
Use of phospho-akt as a biomarker for predicting the response, such as resistance, to a compound, wherein phospho-akt is akt that has been phosphorylated on one or more residues, with the proviso that for akt1, akt2, and akt3 the designation phospho-akt is used to indicate phosphorylation at a site other than t308, t309 or t305 respectively, wherein the compound is a compound of general formula (i) wherein r represents phenyl, thienyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; x represents a group c═y, wherein y stands for oxygen or nitrogen substituted by hydroxy or lower alkoxy; r1 represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl; r2, r3 and r6 represent hydrogen; r4 and r5, independently of each other, represent hydrogen, lower alkyi or lower alkoxy; or r4 and r5 together represent methylenedioxy; and pharmaceutically acceptable derivatives thereof; or wherein r represents phenyl or pyridinyl wherein phenyl is optionally substituted by one or two substituents independently selected from alkyi, halo-lower alkyi, hydroxy-lower alkyi, lower alkoxy-lower alkyi, acyloxy-lower alkyi, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, monoalkylamino, dialkylamino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower alkoxycarbonyl, formyl, cyano, halogen, and nitro; and wherein two adjacent substituents are methylenedioxy; and wherein pyridinyl is optionally substituted by lower alkoxy, amino or halogen; x represents oxygen; r′ represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkyl or cyano-lower alkyl; r2, r3 and r6 represent hydrogen; r4 and r5, independently of each other, represent hydrogen, lower alkyl or lower alkoxy; or r4 and r5 together represent methylenedioxy; and pharmaceutically acceptable derivatives thereof. Methods of treatment of neoplastic and autoimmune diseases with these compounds are also disclosed..
03/20/14
20140080833
Intracellular kinase inhibitors
Intracellular kinase inhibitors and their therapeutic uses for patients with t cell malignancies, b cell malignancies, autoimmune disorders, and transplanted organs.. .


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Autoimmune topics: Autoimmune, Immune Disease, Autoimmune Disease, Immune Diseases, Autoimmune Diseases, Transplant, Immune Disorder, Autoimmune Disorder, Autoimmune Disorders, Infectious, Infectious Disease, Inflammatory Disease, Type 1 Diabetes, Proliferative Disorder, Recurrence

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This listing is a sample listing of patents related to Autoimmune for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Autoimmune with additional patents listed. Browse our RSS directory or Search for other possible listings.
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