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Autoimmune patents



      
           
This page is updated frequently with new Autoimmune-related patent applications. Subscribe to the Autoimmune RSS feed to automatically get the update: related Autoimmune RSS feeds. RSS updates for this page: Autoimmune RSS RSS


Date/App# patent app List of recent Autoimmune-related patents
05/21/15
20150141523
 Compounds for use in the treatment of autoimmune inflammatory disease patent thumbnailnew patent Compounds for use in the treatment of autoimmune inflammatory disease
And salts thereof is useful in the prophylaxis or treatment of inflammatory bowel disease or other inflammatory autoimmune diseases with similar aetiology involving t-cell proliferation or or function.. .
05/21/15
20150141506
 Indane dimers for use in the treatment of autoimmune inflammatory disease patent thumbnailnew patent Indane dimers for use in the treatment of autoimmune inflammatory disease
In some cases r1 is leucine and r is selected from: oh, och3, och2ch3, och2ch2ch3, nh2, nhch2ch2oh, nhch3, n(ch3)2, nh(4-oh-3-benzoic acid).. .
05/21/15
20150141472
 Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use patent thumbnailnew patent Aryl-phenyl-sulfonamido-cycloalkyl compounds and their use
The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-phenyl-sulfonamido-cycloalkyl compounds of the following formula (collectively referred to herein as “apsac compounds”). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, in treatment, for example, of inflammation and/or joint destruction and/or bone loss; of disorders mediated by excessive and/or inappropriate and/or prolonged activation of the immune system; of inflammatory and autoimmune disorders, for example, rheumatoid arthritis, psoriasis, psoriatic arthritis, chronic obstructive pulmonary disease (copd), atherosclerosis, inflammatory bowel disease, ankylosing spondylitis, and the like; of disorders associated with bone loss, such as bone loss associated with excessive osteoclast activity in rheumatoid arthritis, osteoporosis, cancer-associated bone disease, paget's disease and the like, etc.; and of cancer, such as a haematological malignancy, a solid tumour, etc..
Pimco 2664 Limited
05/21/15
20150141414
 Formulation of stable recombinant alpha-fetoprotein conjugated with anti-tumor substance in target-delivery system for treatment of cancer and autoimmune disease patent thumbnailnew patent Formulation of stable recombinant alpha-fetoprotein conjugated with anti-tumor substance in target-delivery system for treatment of cancer and autoimmune disease
Disclosed is a stable formulation based on rafp conjugated with drug delivery system of various classes of pharmacological agents such as dactinomycin, cardionolide, and bufadinolide, among others. In another embodiment, the invention discloses a method of producing rafp in a strain of methylotrophic pichia pastoris yeast, allowing the yeast to replicate, and extracting the newly created rafp.
Legrand International Llc
05/21/15
20150141397
 Substituted anilines as ccr(4) antagonists patent thumbnailnew patent Substituted anilines as ccr(4) antagonists
Aniline compounds are provided which bind to ccr(4) and are useful for the treatment of diseases such as allergic diseases, autoimmune diseases, graft rejection and cancer.. .
Chemocentryx, Inc.
05/21/15
20150141328
 Stimulation of human meibomian gland function patent thumbnailnew patent Stimulation of human meibomian gland function
Disclosed herein are systems and methods for stimulating meibomian gland epithelial cell function by administering to the ocular surface or immediate vicinity of an eye of a subject an effective amount of a pharmaceutical composition containing a pld-inducing compound, such as the cationic amphiphilic drugs (e.g. Azithromycin), androgen or an androgen analogue with androgen effectiveness, corticosteroid, progesterone, igf-1 or an igf-1 analogue (e.g.
The Schepens Eye Research Institute
05/21/15
20150140085
 Formulations comprising ibrutinib patent thumbnailnew patent Formulations comprising ibrutinib
Oral pharmaceutical formulations of ibrutinib and/or a pharmaceutically acceptable salt thereof, methods for their administration, process of their production, and use of these formulations for the treatment of diseases treatable by ibrutinib such as cancer, inflammatory diseases, and autoimmune diseases.. .
Principia Biopharma Inc.
05/21/15
20150140000
 Tlr3 binding agents patent thumbnailnew patent Tlr3 binding agents
Disclosed herein are anti-tlr3 antibodies as well as methods of making and using them. The antibodies are particularly adapted to the treatment of autoimmune or inflammatory diseases using anti-tlr3 antibodies..
Innate Pharma
05/21/15
20150139995
 Methods and compositions for modulating toso activity patent thumbnailnew patent Methods and compositions for modulating toso activity
The present invention is further directed to methods and compositions for modulating the activity of the toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble toso protein..
University Health Network
05/21/15
20150139965
 Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies patent thumbnailnew patent Microsphere-based delivery and ex vivo manipulation of dendritic cells for autoimmune therapies
The present invention relates to tolerogenic mammalian dendritic cells (idcs) and methods for the production of tolerogenic dcs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects.
University Of Pittsburgh - Of The Commonwealth System Of Higher Education
05/14/15
20150133457

Heterocyclic compounds and uses thereof


The present invention relates to pharmaceutical compounds, compositions and methods, especially as they are related to compositions and methods for the treatment and/or prevention of a proliferation disorder, a cancer, a tumor, an inflammatory disease, an autoimmune disease, psoriasis, dry eye or an immunologically related disease, and in some embodiments diseases or disorders related to the dysregulation of kinase such as, but not limited to, egfr (including her), alk, pdgfr, blk, bmx/etk, flt3(d835y), itk, tec, txk, btk, or jak, and the respective pathways.. .
05/14/15
20150133450

Methods and compositions useful for treating diseases involving bcl-2 family proteins with quinoline derivatives


The present invention relates to compositions and methods for cancer treatment comprising compounds of formulae i, ii, and iii. In some aspects, the invention relates to the treatment of b-cell lymphoma or other hematopoietic cancers.
05/14/15
20150133436

Bromodomain inhibitors for treating autoimmune and inflammatory diseases


The use of compounds in the treatment of autoimmune and inflammatory diseases or conditions, pharmaceutical compositions containing such compounds and to methods for identifying compounds for use in the treatment of such diseases or conditions.. .
05/14/15
20150133375

Peptides and methods of using same


We describe peptides and their uses for the treatment of autoimmune, inflammatory and metabolic diseases.. .
05/14/15
20150132788

Establishing the viability of biological samples


The invention relates to a method, a use and a kit for establishing the viability (ability to live) of biological samples using ageladine a. The invention is advantageously suitable for establishing the viability of biological samples which can otherwise be dyed in an intra-cellular manner by fluorescence dyes other than ageladine a not at all or only with difficulty.
05/14/15
20150132369

Nanoliposomal cyclosorin formulations for immunosuppresion and methods for the production thereof


A liposomal formulation for targeting immunotherapy, with synergistic effect in the case of encapsulating an immunosuppressive drug, such as cyclosporine a, and the method of preparing the same. The reduced toxicity and significant reduction of delayed-type hypersensitivity dth) due to extremely reduced dosage, potential therapeutic value in control of chronic transplant rejection, allergies and certain autoimmune diseases, and increased efficacy are some of numerous and significant benefits of the present invention..
05/14/15
20150132326

Immunosuppressive blood cells and methods of producing the same


The present invention refers to a method of producing immunosuppressive blood cells that can be used for the treatment of autoimmune diseases, in particular multiple sclerosis, organ graft rejection and graft-versus-host disease.. .
05/14/15
20150132316

Monoclonal antibodies against nkg2a


The present invention relates to methods of treating immune disorders, particularly autoimmune or inflammatory disorders, and methods of producing antibodies and other compounds for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies or other compounds that prevent the stimulation of nkg2a receptors on nk cells, leading to the lysis of dendritic cells that contribute to the pathology of the disorders..
05/14/15
20150132312

Systems and methods for extracorporeal blood modification


The present invention generally relates to systems and methods for targeted removal of a substance or biomolecule such as a protein from a biological fluid, such as blood. In some cases, the blood may be withdrawn from a subject, treated, and returned to the subject.
05/14/15
20150132302

Vaccine and uses thereof


The present disclosure provides immunogenic compositions, such as vaccines, including dna vaccines, and uses thereof, e.g., to suppress or prevent an immune response and/or to treat or prevent an autoimmune disease.. .
05/07/15
20150126488

Nitrogen-containing bicyclic aromatic heterocyclic compound


[means for solution] it was found that a nitrogen-containing bicyclic heterocyclic compound has the excellent cathepsin s inhibitory effect, thereby completing the invention. The compound of the present invention has the cathepsin s inhibitory effect, and can be used as an agent for preventing and/or treating autoimmune disease, allergic disease, graft rejection of an organ, bone marrow or tissue, systemic lupus erythematosus, or the like..
05/07/15
20150125880

Methods for induction of antigen-specific regulatory t cells


The present invention relates to methods to elicit immature antigen-presenting cells loaded with apoptotic cells or apoptotic bodies. The present invention also relates to methods of obtaining antigen-specific regulatory t cells in vitro or in vivo.
Katholieke Universiteit Leuven
05/07/15
20150125536

Methods and compositions for sustained immunotherapy


This disclosure provides compositions and methods for promoting the formation, expansion and recruitment of tr1 cells and/or breg cells in an antigen-specific manner and treating autoimmune diseases and disorders in a subject in need thereof.. .
Uti Limited Partnership
05/07/15
20150125514

Biomarker


A method of diagnosis, prognosis or treatment of an autoimmune disease in a subject wherein the method comprises detecting aquaporin-1 (aqp1), aquaporin-2 (aqp2), aquaporin-5 (aqp5), aquaporin-7 (aqp7) and/or aquaporin-8 (aqp8) autoantibodies in a sample obtained from said subject.. .
05/07/15
20150125467

Methods for the treatment of b cell-mediated inflammatory diseases


Methods for treating diseases associated with cxcl13 expression, including certain autoimmune and inflammatory diseases such as sjogren's syndrome are provided herein. The methods comprise administering to a subject in need thereof an effective amount of an agent that inhibits cxcl13 activity.
Vaccinex, Inc.
05/07/15
20150125464

Monoclonal antibodies against nkg2a


The present invention relates to methods of treating immune disorders, particularly autoimmune or inflammatory disorders, and methods of producing antibodies and other compounds for use in therapeutic strategies for treating such disorders. Generally, the present methods involve the use of antibodies or other compounds that prevent the stimulation of nkg2a receptors on nk cells, leading to the lysis of dendritic cells that contribute to the pathology of the disorders..
University Of Genova
05/07/15
20150125460

Anti-bcma antibodies


This invention provides antibodies that recognize the b cell maturation antigen (bcma) and that bind naïve b cells, plasma cells, and/or memory b cells. The invention further provides methods for depleting naïve b cells, plasma cells, and memory b cells, and for treating b cell-related disorders, including lymphomas and autoimmune diseases..
Biogen Idec Ma Inc.
05/07/15
20150125450

Bispecific antibodies that neutralize both tnf-alpha and il-6: novel therapeutic agent for autoimmune disease


The present invention concerns compositions and methods of use of bispecific antibodies comprising at least one anti-tnf-α antibody or antigen-binding fragment thereof and at least one anti-il-6 antibody or antigen-binding fragment thereof. Preferably, the bispecific antibody is in the form of a dnl® complex.
Ibc Pharmaceuticals, Inc.
05/07/15
20150125421

Cytokine-based fusion proteins for treatment of immune disorders


The present invention provides fusion proteins including an autoimmune antigen, an allergen antigen or an alloantigen, and an anti-inflammatory cytokine. Compositions and methods including the fusion proteins are also provided..
East Carolina University
05/07/15
20150125390

18f-labelled folate/antifolate analogues


The present invention is directed towards new 18f-folate/antifolate analogue radiopharmaceuticals, wherein the phenyl group within folate structures has been replaced by an 18f-heterocycle, their precursors, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.. .
Merck & Cie
04/30/15
20150118318

Methods of treating inflammatory and autoimmune diseases and disorders


Compositions and methods for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder are described herein. The compositions contain a nanolipogel for sustained delivery of an effective amount of one or more active agents of choice, preferably a drug for treating or ameliorating the symptoms of inflammatory or autoimmune disease or disorder.
Yale University
04/30/15
20150118264

Pharmaceutical composition comprising a polymeric carrier cargo complex and at least one protein or peptide antigen


The present invention is directed to a pharmaceutical composition including (e.g. For use as an adjuvant) a polymeric carrier cargo complex, comprising as a carrier a polymeric carrier formed by disulfide-crosslinked cationic components; and as a cargo at least one nucleic acid molecule, and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease; an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen.
Curevac Gmbh
04/30/15
20150118259

28 kda gst proteins from schistosoma for the use thereof in the treatment of inflammatory autoimmune diseases generating a th1 and/or th17 response


The present invention relates to a product selected from a protein, a fragment of the protein, a derived sequence and a homologous sequence of the protein, the protein including or being constituted by the 28 kda glutathione s-transferase protein from a schistosome selected from schistosoma haematobium, schistosoma mansoni, schistosoma bovis represented respectively by the sequences seq id no: 1, seq id no: 2 and seq id no: 3 for the use thereof in the treatment of an inflammatory autoimmune disease generating a response of type th1 and/or th17.. .
Centre Hospitalier Regional Universitaire De Lille
04/30/15
20150118257

Methods and compositions for manipulating the immune system


Methods and compositions, e.g., therapeutic agents, are provided for modulating gene and/or protein expression of forkhead box protein 1 (foxp1), particularly foxp1a and foxp1d, in cd4+ t cells. Such modulation permits manipulation of the b cell response and antibody production and activity, without depleting the number, production or activity of the t cells.
The Wistar Institute Of Anatomy And Biology
04/30/15
20150118222

Treatment using bruton's tyrosine kinase inhibitors and immunotherapy


Combinations of bruton's tyrosine kinase (btk) inhibitors, e.g., 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, with immunotherapy are provided. Also provided are methods of treating cancers, and autoimmune disorders by administering combinations of bruton's tyrosine kinase (btk) inhibitors, e.g., 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, and an immune checkpoint inhibitor..
Pharmacyclics, Inc.
04/30/15
20150118183

Negatively charged nucleic acid comprising complexes for immunostimulation


The present invention is directed to a pharmaceutical composition including (e.g., for use as an adjuvant) a (negatively charged) nucleic acid comprising complex comprising as a carrier cationic or polycationic compounds (e.g. Peptides, proteins or polymers) and as a cargo at least one nucleic acid (molecule) and at least one antigen that is selected from an antigen from a pathogen associated with infectious disease; an antigen associated with allergy or allergic disease; an antigen associated with autoimmune disease; or an antigen associated with a cancer or tumour disease, or in each case a fragment, variant and/or derivative of said antigen.
Curevac Gmbh


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Autoimmune topics: Autoimmune, Immune Disease, Autoimmune Disease, Immune Diseases, Autoimmune Diseases, Transplant, Immune Disorder, Autoimmune Disorder, Autoimmune Disorders, Infectious, Infectious Disease, Inflammatory Disease, Type 1 Diabetes, Proliferative Disorder, Recurrence

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This listing is a sample listing of patent applications related to Autoimmune for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Autoimmune with additional patents listed. Browse our RSS directory or Search for other possible listings.
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