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|| List of recent Autoimmune-related patents
|Use of a dpp-4 inhibitor in autoimmune diabetes, particularly lada|
The present invention relates to methods for treating and/or preventing autoimmune diabetes, particularly lada, as well as diseases related or associated therewith, comprising the administration of an effective amount of a certain dpp-4 inhibitor, as well as to the use of a certain dpp-4 inhibitor for modifying disease trajectory of autoimmune diabetes (particularly lada).. .
|Compounds and methods for treating autoimmune diseases|
The invention relates to a compound of formula i:. .
|Compounds and therapeutic uses thereof|
The invention relates to compounds, pharmaceutical compositions and methods useful for treating cancer, systemic or chronic inflammation, rheumatoid arthritis, diabetes, obesity, t-cell mediated autoimmune disease, ischemia, and other complications associated with these diseases and disorders.. .
|Engineered cxcl12 alpha locked dimer polypeptide|
The present invention provides a novel cxcl12-α2 locked dimer polypeptide, pharmaceutical compositions thereof, and methods of using said dimer in the treatment of cancer, inflammatory disorders, autoimmune disease, and hiv/aids.. .
|Administration of interferon for prophylaxis against or treatment of pathogenic infection|
The invention provides compositions and methods for the prophylaxis or treatment of diseases or disorders in a subject (e.g., a mammal, such as a human) including, e.g., diseases or disorders caused by biological agents, autoimmune diseases, and cancer. The compositions include a delivery vector (e.g., a viral vector, such as an ad5 vector) encoding an interferon (e.g., ifn-α), and are provided to the subject by, e.g., intranasal or pulmonary administration..
|Use of cytokines and mitogens to inhibit pathological immune responses|
The invention is generally related to methods of treating autoimmune diseases, including both antibody-mediated and cell-mediated disorders.. .
|Genetic polymorphisms associated with rheumatoid arthritis, metods of detection and uses thereof|
The present invention provides compositions and methods based on genetic polymorphisms that are associated with autoimmune disease, particularly rheumatoid arthritis. For example, the present invention relates to nucleic acid molecules containing the polymorphisms, variant proteins encoded by these nucleic acid molecules, reagents for detecting the polymorphic nucleic acid molecules and variant proteins, and methods of using the nucleic acid molecules and proteins as well as methods of using reagents for their detection..
|Abcb5 positive mesenchymal stem cells as immunomodulators|
The present invention is directed to purified preparations of dermal mesenchymal stem cells that are characterized by the cell surface expression of the abcb5 p-glycoprotein. The cells may be used for any purpose that mesenchymal stem cells from other course are used.
|Polypeptides and polynucleotides, and uses thereof as a drug target for producing drugs and biologics|
This invention relates to a novel target for production of immune and non-immune based therapeutics and for disease diagnosis. More particularly, the invention provides therapeutic antibodies against kiaa0746, cd20 or cd55 antigens, which are differentially expressed in cancer and in specific blood cells, and diagnostic and therapeutic usages.
|Methods and compositions for the diagnosis and treatment of cancer and autoimmune disorders|
Compositions, devices, and methods are contemplated for predicting a patient's likelihood of having a disease. An antigen composition can have a plurality of autoantibody reactive antigens associated with a carrier, where at least two of the antigens have quantified and known relative autoantibody reactivities with respect to sera of a population affected by a disease.
|O-nitro compounds and pharmaceutical compositions including same|
The present invention provides o-nitro compounds, pharmaceutical compositions of o-nitro compounds and methods of using o-nitro compounds and/or pharmaceutical compositions thereof to treat or prevent diseases or disorders characterized by abnormal cell proliferation, such as cancer, inflammation, cardiovascular disease and autoimmune disease.. .
|Use of arsenic compounds for treatment of pain and inflammation|
The present invention relates to the use of arsenic compounds such as sodium meta arsenite (naaso2), arsenic trioxide (as2o3), and arsenic hexoxide (as4o6) or combinations thereof, for the treatment of painful, hyperalgesic and/or inflammatory conditions. The present invention also relates to compositions containing the above arsenic compounds for use in the treatment of pain, inflammation and immunological and autoimmune diseases and disorders..
|Vaccines comprising bisphosphonate and methods of use thereof|
The present invention demonstrates that bisphosphonates have an intrinsic adjuvant activity and directly stimulate b cell antibody secretion. Accordingly, the present invention provides vaccines comprising a bisphosphonate, methods for stimulating an immune response, enhancing the immunogenicicty of an immunogen, and methods of treating an infection, an autoimmune disease, an allergy, and/or a cancer using the same..
|Methods and compositions combining immunotherapy with monocyte activation|
Methods of enhancing the effectiveness of an antibody-based therapeutic agent are provided herein. The methods include administering an antibody-based therapeutic and a composition capable of preferentially activating monocytes or macrophages or preferentially depleting b10 cells to a subject in need of such treatment.
The present invention relates generally to the generation and characterization of neutralizing anti-ifn-α monoclonal antibodies with broad reactivity against various ifn-α subtypes. The invention further relates to the use of such anti-ifn-α antibodies in the diagnosis and treatment of disorders associated with increased expression of tun-α, in particular, autoimmune disorders such as insulin-dependent diabetes mellitus (iddm) and systemic lupus erythematosus (sle)..
|Recombinant t cell ligands and antibodies that bind b cells for the treatment of autoimmune diseases|
Methods are disclosed for treating or inhibiting an autoimmune disease in a subject. In some embodiments, the disclosed methods include administering to the subject a therapeutically effective amount of one or more major histocompatibility complex (mhc) molecules including covalently linked first, second and third domains; wherein the first domain is an mhc class ii β1 domain and the second domain is an mhc class ii α1 domain, wherein the amino terminus of the α1 domain is covalently linked to the carboxy terminus of the β1 domain; or wherein the first domain is an mhc class i α1 domain and the second domain is an mhc class i α2 domain, wherein the amino terminus of the α2 domain is covalently linked to the carboxy terminus of the α1 domain; and wherein the third domain is covalently linked to the first domain and comprises an antigen associated with the autoimmune disorder.
|Composition comprising at least to compounds which induces indolamine 2,3 - dioxygenase (ido), for the treatment of an autoimmune disorder or suffering from immune rejection of organs|
A composition and method for using a composition, the composition having at least two compounds, each of which induces indolamine 2,3-dioxygenase, for the treatment of an autoimmune disorder or disease or immune rejection of transplants or gene therapeutically modified cells, wherein the inducers have different mechanism of action and wherein the composition gives rise to a synergistic effect on the ido levels.. .
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Autoimmune topics: Autoimmune, Immune Disease, Autoimmune Disease, Immune Diseases, Autoimmune Diseases, Transplant, Immune Disorder, Autoimmune Disorder, Autoimmune Disorders, Infectious, Infectious Disease, Inflammatory Disease, Type 1 Diabetes, Proliferative Disorder, Recurrence
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