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Autoimmune Disorders

Autoimmune Disorders-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Generation of a mesenchymal stromal cell bank from the pooled mononuclear cells of multiple bone ...
Drk Blutspendedienst Baden-wÜrttemberg-hessen Ggmbh
July 13, 2017 - N°20170198257

The present invention pertains to an improved mesenchymal stromal cell (msc) preparation and a method for producing the same. The invention provides a new strategy to isolate msc from bone marrow mononuclear cells (bm-mncs) by pooling bm-mncs of multiple unrelated (third-party) bone marrow donors. The msc preparation manufactured in accordance with the methodology of the invention is characterized by a ...
Apoptosis signal-regulating kinase inhibitors
Drk Blutspendedienst Baden-wÜrttemberg-hessen Ggmbh
July 13, 2017 - N°20170196844

Wherein x1, x2, x3, x4, x5, x6, x7, x8, r1, r2, r3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or ...
Improved anti-nuclear antibody detection and diagnostics for systemic and non-systemic autoimmune disorders
Immco Diagnostics, Inc.
June 22, 2017 - N°20170176454

Provided are compositions that contain mammalian cells for use in detecting antibodies. The mammalian cells are modified such that they do not contain ledgf protein. The mammalian cells are immobilized on a solid substrate. The compositions can also contain mammalian cells that contain the ledgf protein. Methods for using the cell compositions in diagnostic approaches are included, as are kits ...
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Apoptosis signal-regulating kinase inhibitors
Southern Research Institute
June 22, 2017 - N°20170173031

Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver ...
Cd89 activation in therapy
UniversitÄt Bern
June 15, 2017 - N°20170166640

The invention relates to the use of cd89 activating molecules, in particular fc alpha comprising molecules, and more particularly, iga, for inducing apoptosis in neutrophils. Anti-cd89 antibodies can alternatively be used. The cd89 activation is beneficial in the treatment of various disorders associated with increases in neutrophils, such as autoimmune disorders, inflammatory disorders, netosis, or cystic fibrosis.
Humanized antibodies with increased stability
Innate Pharma
June 08, 2017 - N°20170158763

The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to kir3dl2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by kir3dl2-expressing cells, particularly cd4+t cells, including malignancies such as mycosis fungoides and sezary syndrome, and kir3dl2-expressing autoimmune disorders.
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Disulfur bridge linkers for conjugation of a cell-binding molecule
Suzhou M-conj Biotech Co., Ltd.
June 01, 2017 - N°20170151346

The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of ...
Crystalline forms and processes for the preparation of cannabinoid receptor modulators
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170144993

The present invention relates to crystalline forms of (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid cb2 receptor and are therefore useful in the treatment of cb2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory ...
Use of cinnabarinic acid as a modulator of immune response in autoimmune disorders
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143727

The present invention provides compounds and methods for preventing and treating an immune disorder in a subject.
Methods of treating cancers, immune and autoimmune diseases, and inflammatory diseases based on btk occupancy ...
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143712

In an embodiment, therapeutic methods and uses of bruton's tyrosine kinase (btk) inhibitors for treatment of cancer, inflammation, immune disorders, and autoimmune disorders, including dermatoses, and for transplantation prophylaxis, based on btk occupancies and/or btk resynthesis rates for b cells in various diseases, tissue compartments, including bone marrow and lymph nodes, are described. In an embodiment, dosing regimens for ...
Selective kinase inhibitors
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143706

The present disclosure relates to methods of modulating (for example, inhibiting) activity of jak3, comprising contacting the jak3 with a compound of formula i or pharmaceutically acceptable salt thereof, wherein constituent members are provided hereinwith. The present disclosure further provides novel compounds and compositions as well as their methods of preparation and use. The disclosed jak3 inhibitors may be used ...
Tiopronin prodrugs, pharmaceutical compositions thereof, and methods of use
Suzhou M-conj Biotech Co., Ltd.
May 11, 2017 - N°20170129867

Tiopronin prodrugs, pharmaceutical compositions comprising the tiopronin prodrugs, and methods of using tiopronin prodrugs and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including non-alcoholic steatohepatitis, wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial lung disease, asthma, cystic fibrosis, parkinson's disease, and huntington's disease.
New pharmaceutical compositions and their use for the treatment of autoimmune disorders
Universite Grenoble Alpes
May 11, 2017 - N°20170128536

A pharmaceutical composition in which the active substance includes or is: (i) a protein including the sequence seq id no: 1, representing the april protein, (ii) any derived protein, which is derived from protein of sequence seq id no: 1 by substitution, removal or addition of one or more amino-acids, provided it allows the binding of the derived protein to an astrocyte ...
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Dipeptides as inhibitors of human immunoproteasomes
Cornell University
May 04, 2017 - N°20170121366

The compounds of the present invention are represented by the following compounds having formula (i) where the substituents r1-r10, x, y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
Expression of mirnas in placental tissue
Cornell University
April 27, 2017 - N°20170114343

Provided are human mirnas associated with the generation of immunological tolerance during pregnancy as well as fragments, derivatives and variants thereof for use in immunomodulation. Said mirnas may be used in diagnosis and treatment of disorders associated with a deregulated immune response, autoimmune disorders, pregnancy associated diseases, failure or problems of placentation and complications resulting from allotransplantations. In addition, new ...
Benzimidazole derivatives as pi3 kinase inhibitors
Glaxosmithkline Llc
April 27, 2017 - N°20170112844

This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in ...
Methods and compositions for treating autoimmune and inflammatory conditions
Baylor Research Institute
April 20, 2017 - N°20170106051

Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (apc)-targeted antibody operatively linked to il-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory ...
Dna aptamers specific to cd200r1 and their therapeutic uses
D5pharma Inc.
April 06, 2017 - N°20170096670

Disclosed are short dna aptamers that selectively recognize cd200r1, a protein expressed on the surface of myeloid and lymphoid cells that delivers immune inhibitory signals to modulate inflammation when engaged with its ligand, cd200. Also disclosed is the use of said aptamers as therapeutic agents, for the purpose of decreasing inflammatory response; treatment of spinal cord injury; treatment of ...
Cysteine, n-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions thereof, and methods of use
D5pharma Inc.
March 23, 2017 - N°20170081280

Cysteine, n-acetylcysteine, and penicillamine related compounds, pharmaceutical compositions comprising the cysteine, n-acetylcysteine, and penicillamine related compounds, and methods of using cysteine, n-acetylcysteine, and penicillamine related compounds and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including paracetamol overdose, non-alcoholic steatohepatitis, wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial ...
Detection of shed cd31, diagnosis of atherothrombosis and autoimmune disorders, and methods for analyzing signaling ...
Institut National De La Sante Et De La Recherche Medicale (inserm)
March 16, 2017 - N°20170074891

The present invention stems from the finding that the extracellular domain of cd31 proteins present on blood leukocytes is shed and released in the circulation as a soluble form of cd31. A method for detecting shed cd31 is further disclosed. The invention therefore relates to a method for detecting a shed ectodomain of a transmembrane protein such as cd31 and ...
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut ...
Synlogic, Inc.
March 09, 2017 - N°20170067065

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
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