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Autoimmune Disorders

Autoimmune Disorders-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Methods and compositions for modulating toso activity
University Health Network
January 18, 2018 - N°20180016320

The present invention is further directed to methods and compositions for modulating the activity of the toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble toso protein.
2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof
Guangzhou Institutes Of Biomediciene And Health, Chinese Academy Of Sciences
January 11, 2018 - N°20180008574

The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the bet bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, ...
Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmaceutical compositions containing them and method of ...
Wisconsin Alumni Research Foundation
January 04, 2018 - N°20180002318

Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. The method comprises contacting a reactant of formula i wherein e is a protecting group, —so2-aryl, or —so2...
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Attenuated salmonella bacteria and methods of using
City Of Hope
December 28, 2017 - N°20170368156

Provided herein are attenuated salmonella bacteria for expressing autoantigen alone or in combination with an immunomodulatory, as well as methods of using these bacteria to treat various autoimmune disorders.
Immunomodulation by iap inhibitors
Dana-farber Cancer Institute, Inc.
December 28, 2017 - N°20170368047

The present invention is directed to immune adjuvants containing iap inhibitors, including smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an iap inhibitor and an antigen. Methods of enhancing an immune response by administration of an iap inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods ...
Methods and compositions for treating autoimmune disorders by targeting kv1.3 ion channels with functionalized lipid-derived ...
North Carolina Agricultural And Technical State University
December 14, 2017 - N°20170355998

Synthesis and pharmaceutical compositions of antibody-functionalized nanovesicles encapsulating ion channel knockout sirna, and methods of treating autoimmune diseases associated with increased expression and/or hyperactivity of t cells by selectively targeting memory t cells with the nanoparticles, which deliver their sirna cargo into the cytosol of the tm cell thus reducing ion channel expression and decreasing ca2+ influx.
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Universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
The Trustees Of The University Of Pennsylvania
November 30, 2017 - N°20170342124

The invention provides compositions and methods for adoptive t cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (univir) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.
Sik inhibitor for use in a method of treating an inflammatory and/or immune disorder
University Court Of The University Of Dundee
November 30, 2017 - N°20170342036

The present invention relates to the discovery that salt inducible kinases (siks) suppress the formation of anti-inflammatory molecules such as il-10, which are important for the resolution of inflammation and identifies sik inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.
Novel aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
November 30, 2017 - N°20170342034

The present invention relates to protein-lysine n-methyltransferase smyd2 (set and mynd domain-containing protein 2) inhibitors, in particular smyd2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (i) wherein r1, r2, r3, r4, r5, x and r have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use ...
New pyrazolopyrimidine derivatives as nik inhibitors
Janssen Pharmaceutical Nv
November 23, 2017 - N°20170334915

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
New compounds as nik inhibitors
Janssen Pharmaceutica Nv
November 23, 2017 - N°20170334906

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
New pyrazole derivatives as nik inhibitors
Janssen Pharmaceutica Nv
November 23, 2017 - N°20170334900

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
Compositions and methods of use of phorbol esters
Biosuccess Biotech Co. Ltd.
November 09, 2017 - N°20170319533

Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as hiv and aids, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune ...
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Use of levocetirizine and montelukast in the treatment of autoimmune disorders
October 19, 2017 - N°20170296534

The embodiments described herein include methods and formulations for treating autoimmune disorders. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of levocetirizine and montelukast to a patient in need. The methods and formulations can comprise conventional and/or modified-release elements, providing for drug delivery to the patient.
Polypeptides and uses thereof as a drug for treatment of autoimmune disorders
Compugen Ltd.
September 28, 2017 - N°20170275344

This invention, in at least some embodiments, relates to a protein c1orf32 and its variants and fragments and fusion proteins thereof, and methods of use thereof for immunotherapy, and drug development, including but not limited to as immune modulators and for immune therapy, including for autoimmune disorders.
Modulators of retinoid-related orphan receptor gamma
Orphagen Pharmaceuticals, Inc.
September 21, 2017 - N°20170267712

Methods for modulating (inhibiting or stimulating) retinoid-related orphan receptor γ (rorγ) activity. This modulation has numerous effects, including inhibition of th-17 cell function and/or th-17 cell activity, and inhibition of re-stimulation of th-17 cells, which are beneficial to treatment of inflammation and autoimmune disorders. Stimulation of rorγ results in stimulation of th-17 cell function ...
Azetidinyl phenyl, pyridyl or pyrazinyl carboxamide derivatives as jak inhibitors
Incyte Holdings Corporation
September 07, 2017 - N°20170253598

The present invention provides azetidinyl phenyl, pyridyl, or pyrazinyl carboxamide derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase (jaks) and are useful in the treatment of diseases related to the activity of jak including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
Liquid formulation comprising gm-csf neutralizing compound
Takeda Gmbh
September 07, 2017 - N°20170252436

The present invention relates to aqueous formulations comprising a compound neutralizing gm-csf in concentrations of at least 20 mg/ml, a tonicity modifier, a buffer and one or more of surfactants, amino acids, antioxidants and/or chelators, wherein the composition is stable. The ingredients of the formulation preferably provide stability to the compound neutralizing gm-csf in view of long-term storage. In ...
Compositions and methods for treating b cell mediated autoimmune disorders
Opexa Therapeutics, Inc.
August 31, 2017 - N°20170246272

Provided herein are methods, kits, compositions and uses related to the treatment of a b cell mediated autoimmune disorder with a t cell vaccine comprising a therapeutically effective amount of t cells autologous to the patient and that react to an autoantigen or specific epitope(s) thereof associated with the b cell mediated autoimmune disorder, wherein the treatment is provided ...
Eluting matrix and uses thereof
The General Hospital Corporation
August 31, 2017 - N°20170246250

Cxcl12 polypeptide eluting matrices encapsulating at least one cell are described for use in the treatment of autoimmune disorders.
Piperidin-4-yl azetidine derivatives as jak1 inhibitors
Incyte Holdings Corporation
August 31, 2017 - N°20170246157

The present invention provides piperidin-4-yl azetidine derivatives, as well as their compositions and methods of use, that modulate the activity of janus kinase 1 (jak1) and are useful in the treatment of diseases related to the activity of jak1 including, for example, inflammatory disorders, autoimmune disorders, cancer, and other diseases.
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