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Autoimmune Disorder

Autoimmune Disorder-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Novel aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
April 12, 2018 - N°20180099937

The present invention relates to protein-lysine n-methyltransferase smyd2 (set and mynd domain-containing protein 2) inhibitors, in particular smyd2-inhibitory substituted cyanoguanidine- pyrazolines of general formula (i), wherein r1, r2, r3, r4 and r5 have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use for ...
Controlled release pharmaceutical compositions comprising a fumaric acid ester
Fwp Ip Aps
April 12, 2018 - N°20180098957

The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e. G. Psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance ...
Targeted apheresis using binding agents or ligands immobilized on membranes
April 05, 2018 - N°20180093032

This invention teaches a method of targeted apheresis that can be used to treat a variety of different diseases including infectious diseases, autoimmune disorders, and reducing circulating biomarkers associated with certain disorders e. G. Pre-eclampsia. This invention discloses the use of apheresis membranes as the support matrix upon which one or more different binding agents (e. G. Antibodies, aptamers, binding ...
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Substituted n-(lh-indazol-4-yl)imidazo[l,2-a]pyridine-3-carboxamide compounds as type iii receptor tyrosine ...
March 29, 2018 - N°20180086758

And pharmaceutically acceptable salts thereof in which r1, r2, r3, r4, r5 and r6 have the meanings given in the specification, are inhibitors of cfms and are useful in the treatment of fibrosis, bone-related diseases, cancer, autoimmune disorders, inflammatory diseases, cardiovascular diseases, pain and burns in a mammal.
Eluting matrix and uses thereof
The General Hospital Corporation
March 15, 2018 - N°20180075706

Cxcl12 polypeptide eluting matrices encapsulating at least one cell are described for use in the treatment of autoimmune disorders.
Shmt inhibitors
The Trustees Of Princeton University
March 15, 2018 - N°20180072751

The disclosure provides compounds of formulae (i)-(ix). The disclosed compounds are capable of inhibiting a mammalian shmt. Compounds of the disclosure have numerous uses, such as for treatment of cancer or autoimmune disorders.
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Display platform from bacterial spore coat proteins
The United States Of America, As Represented By The Secretary, Department Of Health And Human Serv
March 01, 2018 - N°20180055925

A particle construct is disclosed that includes a synthetic core with a solid surface coated with a lipid bilayer, spovm adhered to the lipid bilayer; and spoiva adsorbed to the spovm. In additional embodiments, an agent of interest can be covalently linked to the spoiva. In specific, non-limiting examples, the agent of interest is an enzyme, a detectable marker, a ...
Methods and compositions for the diagnosis and treatment of cancer and autoimmune disorders
Immport Therapeutics, Inc.
February 15, 2018 - N°20180045735

Compositions, devices, and methods are contemplated for predicting a patient's likelihood of having a disease. An antigen composition can have a plurality of autoantibody reactive antigens associated with a carrier, where at least two of the antigens have quantified and known relative autoantibody reactivities with respect to sera of a population affected by a disease. The at least two antigens ...
Methods of treating cancers, autoimmune disorders, and other conditions associated with chronic inflammation
Mymd Pharmaceuticals, Inc.
February 15, 2018 - N°20180042909

In one aspect, a method of treating a disorder associated with chronic inflammation includes administering to an individual in need thereof a therapeutically effective amount of isomyosmine or a pharmaceutically acceptable salt thereof. In some aspects, the disorder is a cancer, an autoimmune disorder, hypertension, or autism. In other aspects, isomyosmine is administered to treat viral infections or disorders associated ...
N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and ...
Pimco 2664 Limited
February 08, 2018 - N°20180037544

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e. G., diseases) including, inflammation and/or joint destruction ...
Novel binding proteins comprising a ubiquitin mutein and antibodies or antibody fragments
Navigo Proteins Gmbh
February 01, 2018 - N°20180030140

The present invention relates novel binding molecules comprising a ubiquitin mutein (affilin®) and a monoclonal antibody or antibody fragment. The invention refers to bispecific and/or bivalent binding proteins or to a therapeutically or diagnostically active component. The invention further relates to the use of these binding proteins' medicine, preferably for use in the treatment of cancer or autoimmune ...
Biomarkers for rheumatoid arthritis
Universiteit Hasselt
February 01, 2018 - N°20180030122

The present invention relates to the diagnosis of autoimmune disorders, more specifically to the diagnosis of rheumatoid disorders, chronic autoimmune arthritis and even more specifically to the diagnosis of rheumatoid arthritis. A biomarker panel is provided which can be used to detect if a subject has rheumatoid arthritis. Also described are methods of identification of such biomarkers.
Chemical synthesis and screening of bicyclic peptide libraries
Ohio State Innovation Foundation
February 01, 2018 - N°20180030094

Disclosed herein are bicyclic peptide compounds, compositions comprising same, methods for making same, and libraries comprising same. The disclosed compounds, in various aspects, are useful for treating a variety of disorders, including inflammatory disorders, autoimmune disorders, and disorders of uncontrolled cellular proliferation. This abstract is intended as a scanning tool for purposes of searching in the particular art and is ...
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Methods of inducing indolamine 2,3 - dioxygenase (ido)
Idogen Ab
February 01, 2018 - N°20180028621

A composition and method for using a composition, the composition having at least two compounds, each of which induces indolamine 2,3-dioxygenase, for the treatment of an autoimmune disorder or disease or immune rejection of transplants or gene therapeutically modified cells, wherein the inducers have different mechanism of action and wherein the composition gives rise to a synergistic effect on the ...
Compositions and methods of using a soluble tnf-alpha receptor modified for increased half-life
Dnx Biotech, Llc
February 01, 2018 - N°20180028612

Methods and pharmaceutical compositions for preventing and/or treating acute and chronic inflammation and autoimmune diseases are provided herein. Tumor necrosis factor-α (tnfα) promotes an inflammatory response, which causes clinical problems associated with inflammation and autoimmune disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa, and refractory asthma. Tnfα is ...
Controlled release pharmaceutical compositions comprising a fumaric acid ester
Fwp Ip Aps
February 01, 2018 - N°20180028483

The present invention relates to controlled release pharmaceutical compositions comprising fumaric acid ester(s) as active substance(s). The compositions are suitable for use in the treatment of e. G. Psoriasis or other hyperproliferative, inflammatory or autoimmune disorders and are designated to release the fumaric acid ester in a controlled manner so that local high concentrations of the active substance ...
Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
Idera Pharmaceuticals, Inc.
January 25, 2018 - N°20180023085

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
Treatment of autoimmune disorders with cd154 antibodies
Ucb Biopharma Sprl
January 25, 2018 - N°20180022812

The present invention relates to a method of treating an autoimmune or inflammatory disease or a neurodegenerative disease with an antibody to cd154.
Methods and compositions for modulating toso activity
University Health Network
January 18, 2018 - N°20180016320

The present invention is further directed to methods and compositions for modulating the activity of the toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble toso protein.
2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof
Guangzhou Institutes Of Biomediciene And Health, Chinese Academy Of Sciences
January 11, 2018 - N°20180008574

The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the bet bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, ...
Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmaceutical compositions containing them and method of ...
Wisconsin Alumni Research Foundation
January 04, 2018 - N°20180002318

Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. The method comprises contacting a reactant of formula i wherein e is a protecting group, —so2-aryl, or —so2...
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