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Autoimmune Disorder

Autoimmune Disorder-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Methods and compositions for modulating toso activity
University Health Network
January 18, 2018 - N°20180016320

The present invention is further directed to methods and compositions for modulating the activity of the toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble toso protein.
2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof
Guangzhou Institutes Of Biomediciene And Health, Chinese Academy Of Sciences
January 11, 2018 - N°20180008574

The present invention relates to the technical field of medicinal chemistry, and in particular discloses a 2-oxo-1,2-dihydrobenzo[cd]indole compound and use thereof. The compound and pharmaceutically acceptable salt, isomer, racemate, prodrug, co-crystallized complex, hydrate, and solvate thereof can effectively inhibit the bet bromodomain receptor, and can be used for preparing a medicine for treating cancers, cell proliferative disorders, ...
Synthesis of cyclopropyl indoles and cyclohepta[b]indoles, pharmaceutical compositions containing them and method of ...
Wisconsin Alumni Research Foundation
January 04, 2018 - N°20180002318

Methods of making indole analogs using a rhodium-containing catalyst are described, along with methods of using the compounds to treat hyperglycemic, hyperlipidemic, or autoimmune disorders in mammals, and corresponding pharmaceutical compositions. Disclosed herein is a method of making indoles. The method comprises contacting a reactant of formula i wherein e is a protecting group, —so2-aryl, or —so2...
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Attenuated salmonella bacteria and methods of using
City Of Hope
December 28, 2017 - N°20170368156

Provided herein are attenuated salmonella bacteria for expressing autoantigen alone or in combination with an immunomodulatory, as well as methods of using these bacteria to treat various autoimmune disorders.
Immunomodulation by iap inhibitors
Dana-farber Cancer Institute, Inc.
December 28, 2017 - N°20170368047

The present invention is directed to immune adjuvants containing iap inhibitors, including smac mimetics. The invention further provides pharmaceutical compositions and vaccines containing an iap inhibitor and an antigen. Methods of enhancing an immune response by administration of an iap inhibitor, methods of treating or preventing cancer, methods of treating or preventing infections, methods of treating autoimmune disorders, and methods ...
Bicyclic compounds, compositions and medicinal applications thereof
December 21, 2017 - N°20170362225

These compounds are useful in the treatment, prevention, prophylaxis, management, or adjunct treatment of all medical conditions related to inhibition of retinoic acid-related orphan receptor gamma (rorγ) such as inflammatory and/or autoimmune disorder, rheumatoid arthritis, psoriasis, psoriatic arthritis, multiple sclerosis, inflammatory bowel disease, allergic diseases, asthma, copd, cancer, cell proliferation, type 1 diabetes, myasthenia gravis, hematopoetic disfunction, systemic ...
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N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)-benzenesulfonamide compounds and ...
Pimco 2664 Limited
December 07, 2017 - N°20170349551

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e. G., diseases) including, inflammation and/or joint destruction ...
Universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
The Trustees Of The University Of Pennsylvania
November 30, 2017 - N°20170342124

The invention provides compositions and methods for adoptive t cell therapy in treating a variety of disorders including cancer, infections, and autoimmune disorders. In one embodiment, the invention provides a universal immune receptor (univir) that comprises an extracellular label binding domain, a transmembrane domain, and a cytoplasmic domain or otherwise an intracellular domain.
Sik inhibitor for use in a method of treating an inflammatory and/or immune disorder
University Court Of The University Of Dundee
November 30, 2017 - N°20170342036

The present invention relates to the discovery that salt inducible kinases (siks) suppress the formation of anti-inflammatory molecules such as il-10, which are important for the resolution of inflammation and identifies sik inhibitors that may be used to treat disorders associated with undesirable inflammation, such as inflammatory bowel disease and/or autoimmune disorders.
Novel aryl-cyanoguanidine compounds
Bayer Pharma Aktiengesellschaft
November 30, 2017 - N°20170342034

The present invention relates to protein-lysine n-methyltransferase smyd2 (set and mynd domain-containing protein 2) inhibitors, in particular smyd2-inhibitory substituted cyanoguanidine-pyrazolines of general formula (i) wherein r1, r2, r3, r4, r5, x and r have the meaning as described and defined herein, as well as to pharmaceutical compositions comprising compounds according to the invention and to their prophylactic and therapeutic use ...
New pyrazolopyrimidine derivatives as nik inhibitors
Janssen Pharmaceutical Nv
November 23, 2017 - N°20170334915

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
New compounds as nik inhibitors
Janssen Pharmaceutica Nv
November 23, 2017 - N°20170334906

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
New pyrazole derivatives as nik inhibitors
Janssen Pharmaceutica Nv
November 23, 2017 - N°20170334900

The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a mammal, and in particular to inhibitors of nf-κb-inducing kinase (nik—also known as map3k14) useful for treating diseases such as cancer, inflammatory disorders, metabolic disorders and autoimmune disorders. The invention is also directed to pharmaceutical compositions comprising such compounds, to ...
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Compositions and methods of use of phorbol esters
Biosuccess Biotech Co. Ltd.
November 09, 2017 - N°20170319533

Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as hiv and aids, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune ...
Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
November 02, 2017 - N°20170316169

A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune ...
Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
November 02, 2017 - N°20170316168

A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune ...
Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
November 02, 2017 - N°20170316167

A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune ...
Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
November 02, 2017 - N°20170316166

A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune ...
Methods of treating graft versus host disease using il-2 muteins
November 02, 2017 - N°20170313753

Described herein are immunosuppressive molecules including immunosuppressive variants of il-2, and use of such molecules to treat inflammatory and autoimmune disorders.
Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
Ubiome, Inc.
October 26, 2017 - N°20170308660

A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune ...
Method and system for microbiome-derived diagnostics and therapeutics for autoimmune system conditions
Ubiome, Inc.
October 26, 2017 - N°20170308659

A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune ...
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