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Autoimmune Disorder

Autoimmune Disorder-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Novel compounds useful as s100-inhibitors
Active Biotech Ab
July 20, 2017 - N°20170204098

A compound of formula (i) or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor of interactions between s100a9 and interaction partners such as rage, tlr4 and emmprin and as such is useful in the treatment of disorders such as cancer, autoimmune disorders, inflammatory disorders and neurodegenerative disorders.
Disulfur bridge linkers for conjugation of a cell-binding molecule
Suzhou M-conj Biotech Co., Ltd.
July 20, 2017 - N°20170202975

The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of ...
Generation of a mesenchymal stromal cell bank from the pooled mononuclear cells of multiple bone ...
Drk Blutspendedienst Baden-wÜrttemberg-hessen Ggmbh
July 13, 2017 - N°20170198257

The present invention pertains to an improved mesenchymal stromal cell (msc) preparation and a method for producing the same. The invention provides a new strategy to isolate msc from bone marrow mononuclear cells (bm-mncs) by pooling bm-mncs of multiple unrelated (third-party) bone marrow donors. The msc preparation manufactured in accordance with the methodology of the invention is characterized by a ...
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Improved anti-nuclear antibody detection and diagnostics for systemic and non-systemic autoimmune disorders
Immco Diagnostics, Inc.
June 22, 2017 - N°20170176454

Provided are compositions that contain mammalian cells for use in detecting antibodies. The mammalian cells are modified such that they do not contain ledgf protein. The mammalian cells are immobilized on a solid substrate. The compositions can also contain mammalian cells that contain the ledgf protein. Methods for using the cell compositions in diagnostic approaches are included, as are kits ...
Pyrrolopyrimidine compounds, use as inhibitors of the kinase lrrk2, and methods for preparation thereof
Southern Research Institute
June 22, 2017 - N°20170174694

The present disclosure is concerned with certain pyrrolopyrimidine compounds that are capable of inhibiting certain protein kinases, and especially the leucine-rich repeat kinase 2 (lrrk2) protein. Compounds of the present disclosure can be used to treat a number of disorders caused by or associated with abnormal lrrk2 kinase activity. Compounds of the present disclosure can be used to treat disorders including ...
Apoptosis signal-regulating kinase inhibitors
Southern Research Institute
June 22, 2017 - N°20170173031

Wherein variables are as defined above. The compounds have apoptosis signal-regulating kinase (“ask1”) inhibitory activity, and are thus useful in the treatment of ask1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases, diabetes, diabetic nephropathy, cardio-renal diseases, including kidney disease, fibrotic diseases, respiratory diseases, copd, idiopathic pulmonary fibrosis, acute lung injury, acute and chronic liver ...
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Methods and compositions for the generation and maintenance of regulatory t cells
The Brigham And Women's Hospital, Inc.
June 15, 2017 - N°20170165325

Methods and compositions for generating and maintaining induced regulatory t cells (itregs) are provided. Methods and compositions for treating an autoimmune disorder, organ transplant rejection, graft versus host disease or allergic or hypersensitivity and inflammation are also provided.
Humanized antibodies with increased stability
Innate Pharma
June 08, 2017 - N°20170158763

The present invention provides antibodies having improved stability. Included are antibodies that are capable of binding to kir3dl2 polypeptides. The antibodies are suitable for the treatment of disorders characterized by kir3dl2-expressing cells, particularly cd4+t cells, including malignancies such as mycosis fungoides and sezary syndrome, and kir3dl2-expressing autoimmune disorders.
Novel benzimidazole derivatives as kinase inhibitors
Selvita S.a.
June 01, 2017 - N°20170152249

The present invention relates to derivatives of benzimidazoles of formula (i) as disclosed herein as well as pharmaceutical compositions comprising said derivatives. The derivates according to the present invention are serine/threonine and tyrosine kinase-inhibitors, particularly of pim1-3- and dyrk1a-kinases and may particularly be used in the treatment of diseases linked to these kinases, such as e. ...
Disulfur bridge linkers for conjugation of a cell-binding molecule
Suzhou M-conj Biotech Co., Ltd.
June 01, 2017 - N°20170151346

The present invention relates to novel disulfur bridge linkers containing hydrazine used for the specific conjugation of compounds/cytotoxic agents to a cell-binding molecule, through bridge linking a pair of thiols on the cell-binding molecule. The invention also relates to methods of making such linkers, and of using such linkers in making homogeneous conjugates, as well as of application of ...
Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170145417

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, ...
Crystalline forms and processes for the preparation of cannabinoid receptor modulators
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170144993

The present invention relates to crystalline forms of (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid cb2 receptor and are therefore useful in the treatment of cb2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory ...
Use of cinnabarinic acid as a modulator of immune response in autoimmune disorders
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143727

The present invention provides compounds and methods for preventing and treating an immune disorder in a subject.
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Selective kinase inhibitors
Suzhou M-conj Biotech Co., Ltd.
May 25, 2017 - N°20170143706

The present disclosure relates to methods of modulating (for example, inhibiting) activity of jak3, comprising contacting the jak3 with a compound of formula i or pharmaceutically acceptable salt thereof, wherein constituent members are provided hereinwith. The present disclosure further provides novel compounds and compositions as well as their methods of preparation and use. The disclosed jak3 inhibitors may be used ...
Tiopronin prodrugs, pharmaceutical compositions thereof, and methods of use
Suzhou M-conj Biotech Co., Ltd.
May 11, 2017 - N°20170129867

Tiopronin prodrugs, pharmaceutical compositions comprising the tiopronin prodrugs, and methods of using tiopronin prodrugs and pharmaceutical compositions thereof for treating liver, kidney, lung, neurological, inflammatory, and autoimmune disorders including non-alcoholic steatohepatitis, wilson's disease, cystinuria, irritable bowel disorder, ulcerative colitis, rheumatoid arthritis, chronic obstructive pulmonary disease, interstitial lung disease, asthma, cystic fibrosis, parkinson's disease, and huntington's disease.
New pharmaceutical compositions and their use for the treatment of autoimmune disorders
Universite Grenoble Alpes
May 11, 2017 - N°20170128536

A pharmaceutical composition in which the active substance includes or is: (i) a protein including the sequence seq id no: 1, representing the april protein, (ii) any derived protein, which is derived from protein of sequence seq id no: 1 by substitution, removal or addition of one or more amino-acids, provided it allows the binding of the derived protein to an astrocyte ...
Bacteria engineered to treat diseases that benefit from reduced gut inflammation and/or tightened gut ...
Synlogic, Inc.
May 11, 2017 - N°20170128499

Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
Dipeptides as inhibitors of human immunoproteasomes
Cornell University
May 04, 2017 - N°20170121366

The compounds of the present invention are represented by the following compounds having formula (i) where the substituents r1-r10, x, y, k, m, n, q, and s are as defined herein. These compounds are used in the treatment of cancer, immunologic disorders, autoimmune disorders, neurodegenerative disorders, or inflammatory disorders or for providing immunosuppression for transplanted organs or tissues.
Expression of mirnas in placental tissue
Cornell University
April 27, 2017 - N°20170114343

Provided are human mirnas associated with the generation of immunological tolerance during pregnancy as well as fragments, derivatives and variants thereof for use in immunomodulation. Said mirnas may be used in diagnosis and treatment of disorders associated with a deregulated immune response, autoimmune disorders, pregnancy associated diseases, failure or problems of placentation and complications resulting from allotransplantations. In addition, new ...
Benzimidazole derivatives as pi3 kinase inhibitors
Glaxosmithkline Llc
April 27, 2017 - N°20170112844

This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in ...
Methods and compositions for treating autoimmune and inflammatory conditions
Baylor Research Institute
April 20, 2017 - N°20170106051

Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (apc)-targeted antibody operatively linked to il-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory ...
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