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Autoimmune Disease

Autoimmune Disease-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Method and kit for the predictive prognosis of responsiveness to treatments of autoimmune diseases
Universita' Degli Studi Di Roma "la Sapienza"
September 14, 2017 - N°20170261505

The present invention relates to the use of one or more mhc class i molecules dextramers (dextramers®) associated with peptides corresponding to apoptotic epitopes of human cd8+ t cells for the predictive prognosis of responsiveness or non-responsiveness to treatments and/or for monitoring the therapeutic effectiveness of treatments with biological medicaments that block and/or inhibit tnf, and/or ...
Oral administration of an anti-cd20 antibody for treatment of autoimmune disease
Universita' Degli Studi Di Roma "la Sapienza"
September 14, 2017 - N°20170260283

The present invention provides a method for treating or delaying the onset of an autoimmune condition in a human subject. An effective oral dose of an anti-cd20 antibody is administered to the subject. Oral administration of such antibodies as rituximab, ocrelizumab, ofatumumab, obinutuzumab, tositumomab, or ibritumomab are useful in a method of decreasing innate inflammatory cytokines, such as and tnf-a, ...
Compositions for expanding regulatory t cells (treg), and treating autoimmune and inflammatory diseases and conditions
The Regents Of The University Of California
September 14, 2017 - N°20170260236

Provided are compositions, including isolated, synthetic or recombinant peptides for: expanding regulatory t cells (treg) populations; for treating or ameliorating a vascular inflammation, and kawasaki disease (kd) or a pediatric acute vasculitis of the coronary arteries, including vascular coronary abnormalities, and acute or chronic vascular inflammatory abnormalities, and methods for making and using them. Provided are immunotherapies for promoting expansion ...
Autoimmune Disease Patent Pack
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Autoimmune Disease Patent Applications
Download 255+ Autoimmune Disease-related PDFs
For professional research & prior art discovery
inventor
  • 255+ full patent PDF documents of Autoimmune Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Pharmaceutical composition for treating or alleviating an autoimmune disease and/or complication thereof and/or ...
Industrial Technology Research Institute
September 14, 2017 - N°20170258865

The present disclosure provides a pharmaceutical composition for treating or alleviating an autoimmune disease and/or complication thereof and/or nephritis, including: an effective amount of an extract of a plant belonging to rutaceae as an effective ingredient for treating or alleviating the autoimmune disease and/or complication thereof and/or nephritis, wherein the autoimmune disease is selected from a ...
Methods and compositions for modified t cells
The Trustees Of The University Of Pennsylvania
September 14, 2017 - N°20170258835

The present invention relates to compositions and methods for generating modified cells with nucleic acid encoding a t cell receptor (tcr), a nucleic acid encoding a bispecific antibody, affinity molecule chimeric receptor, bispecific affinity molecule, or a chimeric ligand engineered activation receptor (clear). One aspect includes a method for generating a modified t cell. Also included are methods and pharmaceutical ...
Fgl2 expressing regulatory t cells
Veritas Therapeutics Inc.
September 14, 2017 - N°20170258834

This application relates to methods and compositions for inducing immune tolerance. Specifically, methods and uses of regulatory t cells (treg) and associated compositions for the induction of immune tolerance are described. The methods and uses may be used to prevent transplant rejection, and in the treatment of diseases or conditions such as graft versus host disease, autoimmune disease and allergies. ...
Autoimmune Disease Patent Pack
Download 255+ patent application PDFs
Autoimmune Disease Patent Applications
Download 255+ Autoimmune Disease-related PDFs
For professional research & prior art discovery
inventor
  • 255+ full patent PDF documents of Autoimmune Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Treatments for autoimmune disease
The Provost, Fellows, Foundation Scholars, And The Other Members Of Board,of The College Of The Holy
September 14, 2017 - N°20170258797

The invention relates to a novel approach to the treatment of autoimmune diseases, particularly multiple sclerosis. In a further embodiment of the invention there is provided a molecule capable of acting as substrate for the queuine-insertase enzyme complex and where said molecule is not a substrate for hypoxanthine-guanine phosphoribosyltransferase and said molecule has the effect of lowering interferon gamma, for ...
Pharmaceutical formulations of a bruton's tyrosine kinase inhibitor
Pharmacyclics Llc
September 14, 2017 - N°20170258729

Described herein are pharmaceutical formulations of bruton's tyrosine kinase (btk) inhibitor 1-((r)-3-(4-amino-3-(4-phenoxyphenyl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one. Also disclosed are methods of using the btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, ...
Method for the detection of antigen presentation
Deutsches Krebsforschungszentrum Stiftung Des öffentlichen Rechts
September 07, 2017 - N°20170254803

The present invention pertains to a method for detecting antigen presentation via antigen presenting molecules such as major histocompatibility complex (mhc) class i or ii. The invention deploys a first binding agent specific for the antigen epitope and a second binding agent specific for the antigen presenting molecule. The binding agents of the invention are coupled to proximity probes which ...
Novel imidazopyridazine compounds and their use
Hutchison Medipharma Limited
September 07, 2017 - N°20170253618

This disclosure provides novel imidazopyridazine compounds of formula (i) and pharmaceutical acceptable salt thereof, pharmaceutical compositions containing them, a process for preparing them, and their practical effect in inhibiting pi3k and potential use in treating a disease responsive to inhibition of pi3k, for example, an inflammatory disease, autoimmune disease or cancer.
Probiotic bifidobacterium adolescentis strains
Chr. Hansen A/s
September 07, 2017 - N°20170252382

The present invention relates to novel isolated strains of bifidobacterium adolescentis which are capable of i) increasing the trans-epithelial electrical resistance (ter) of a caco-2 cell monolayer after 10 h treatment to more than 120% of ter at treatment start, ii) inducing secretion of >200 pg/ml of il-10, and/or iii) inducing an il-10:il-12 ratio>1 when co-incubated ...
Method for treating parkinson disease, neurodegenerative disorders, and autoimmune diseases
Chr. Hansen A/s
September 07, 2017 - N°20170252369

The embodiments herein relate to a therapeutic method for the treatment of parkinson disease, other neurodegerative disorders, and autoimmune diseases. The method includes providing sodium thiosulfate through any method of administration (orally, intravenously, through inhalation, intravesically, vaginally, rectal route, sublingually, ophthalmically, or topically) and is given with one or more pharmaceutically acceptable carriers or excipients. The sodium thiosulfate safely and ...
Nucleic acid capable of inhibiting expression of beta-2gpi
Kyowa Hakko Kirin Co., Ltd.
August 31, 2017 - N°20170247701

The present invention provides a nucleic acid having activity to suppress expression of β2gpi, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as aps, sle and the like and thrombosis in hemodialysis.
Autoimmune Disease Patent Pack
Download 255+ patent application PDFs
Autoimmune Disease Patent Applications
Download 255+ Autoimmune Disease-related PDFs
For professional research & prior art discovery
inventor
  • 255+ full patent PDF documents of Autoimmune Disease-related inventions.
  • Exact USPTO filing data with full-text, images, drawings & claims.
  • Index pages: Table View and Image-Grid View layouts. All images in each PDF.
Modulation of ptpra to treat arthritis
The Regents Of The University Of California
August 31, 2017 - N°20170247469

Presented is a method for treating inflammation and autoimmune diseases through the use of a phosphatase rheumatoid arthritis (pt-pra) antagonist.
Method and compositions for inducing differentiation of myeloid derived suppressor cell to treat cancer and ...
Ose Immunotherapeutics
August 31, 2017 - N°20170247464

The present invention pertains to the field of immunoterapy. More specifically, the present invention provides a method for differentiating myeloid-derived suppressor cells (mdsc) into non suppressive cells, by administering a compound blocking the interaction between sirpa and cd47 to a patient in need thereof in order to reduce mdsc-induced immunodepression and consequently allow appropriate immune responses in cancers, infectious diseases, ...
Methods of treating inflammatory and autoimmune diseases with natalizumab
Biogen Ma, Inc.
August 31, 2017 - N°20170247457

Natalizumab is a safe and efficacious treatment for inflammatory and autoimmune diseases, such as multiple sclerosis, crohn's disease, and rheumatoid arthritis. Rare occurrences of progressive multifocal leucoencephalopathy during treatment suggest the possibility that it may be related to natalizumab treatment. Monitoring for jcv and informing caregivers and patients about the manifestations of progressive multifocal leucoencephalopathy can improve the safety of ...
T-cell redirecting bispecific antibodies for treatment of disease
Ibc Pharmaceuticals, Inc.
August 31, 2017 - N°20170247417

The present invention concerns compositions and methods of use of t-cell redirecting complexes, with at least one binding site for a t-cell antigen and at least one binding site for an antigen on a diseased cell or pathogen. Preferably, the complex is a dnl™ complex. More preferably, the complex comprises a bispecific antibody (bsab). Most preferably, the bsab is ...
Targeted delivery of tertiary amine-containing drug substances
Seattle Genetics, Inc.
August 31, 2017 - N°20170247412

Compounds and compositions are disclosed in which a quaternized drug unit is linked to a targeting ligand unit from which a tertiary amine-containing drug is released at the targeted site of action. Methods for treating diseases characterized by the targeted abnormal cells, such as cancer or an autoimmune disease using the compounds and compositions of the invention are also disclosed.
(z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide tablet formulations with improved stability
Sanofi
August 31, 2017 - N°20170247319

The invention relates to solid pharmaceutical compositions comprising (z)-2-cyano-3-hydroxy-but-2-enoic acid-(4′-trifluoromethylphenyl)-amide, as well as a process for the preparation of the same, methods of using such compositions to treat subjects suffering from autoimmune diseases in particular systemic lupus erythematosus or chronic graft-versus-host disease, multiple sclerosis or rheumatoid arthritis.
Concentrated methotrexate solutions
Medac Gesellschaft Fuer Klinische Spezialpraepararate Mbh
August 31, 2017 - N°20170246172

Concentrated methotrexate solutions are described which are suitable for the use of an active substance in the production of a parenterally administered medicament for the treatment of inflammatory autoimmune diseases. The methotrexate is added to a pharmaceutically acceptable solvent at a concentration of more than 25 mg/ml.
Anti-pd-1 monoclonal antibody and obtaining method therefor
Beijing Jingyitaixiang Technology Development Co., Ltd.
August 24, 2017 - N°20170240644

The invention provides human monoclonal antibodies that specifically bind to pd-1 with high affinity. The anti-pd-1 monoclonal antibodies were screened from a synthetic antibody library, and affinity maturation was performed. The synthetic antibody libraries used to select for the high affinity anti-pd-1 monoclonal antibodies were made by replacing the light chain cdr1, cdr2 and cdr3 and heavy chain cdr1, cdr 2 ...
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