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Atherosclerosis

Atherosclerosis-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Diagnostics and methods for treatment of non-alcoholic hepatic steatosis and hepatic steatohepatitis, and prevention of ...
Volant Holdings Gmbh
April 12, 2018 - N°20180099001

The present invention is directed to a system characterization of nash that combines modeling and biomarkers, enabling pharmaceutical compositions and methods of treatment that relate to the inhibition, resolution and/or prevention of non alcoholic fatty liver disease (nafld) and non alcoholic steatohepatitis (nash). Said conditions are liver related complications among the array of manifestations of metabolic syndromes, including type 2 ...
Ldl quantitation and methods of use
April 05, 2018 - N°20180092964

The present invention features, in certain aspects, methods of promoting endocytosis of ldl with α1pi or peptides derived from α1pi. The present invention also provides methods for decreasing ldl levels in response to α1pi augmentation therapy. In preferred embodiments, the methods are suitable for a subject who is suffering from a disease or disorder ...
Compositions of protein receptor tyrosine kinase inhibitors
Purdue Pharma L.p.
March 29, 2018 - N°20180086777

The present invention relates to novel synthetic substituted heterocyclic compounds and pharmaceutical compositions containing the same that are capable of inhibiting or antagonizing a family of receptor tyrosine kinases, tropomysosin related kinases (trk), in particular the nerve growth factor (ngf) receptor, trka. The invention further concerns the use of such compounds in the treatment and/or prevention of pain, cancer, ...
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Methods for detecting an increased risk for coronary heart disease
Board Of Regents, The University Of Texas System
March 22, 2018 - N°20180080083

The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease ...
Methods for treating cancer with trka receptor tyrosine kinase antagonists
March 22, 2018 - N°20180078545

The disclosure further concerns the use of such compounds in the treatment and/or prevention of certain types of cancers, pain, inflammation, restenosis, atherosclerosis, psoriasis, thrombosis, alzheimer's, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination.
Tricyclic analogues, preparation method and uses thereof
Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences
March 08, 2018 - N°20180064696

The present invention relates to a series of analogues of natural product pyripyropene a represented by general formula i and a preparation method and use thereof. More particularly, the present invention relates to analogues of the natural product pyripyropene a, a preparation method and use thereof as the acyl-coa:cholesterol acyltransferase 2 (acat2) inhibitors for the treatment of cardiovascular diseases such ...
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Atherosclerosis imaging agents and methods of using the same
The General Hospital Corporation
March 01, 2018 - N°20180055953

Methods for detecting the presence of atherosclerotic structures in order to diagnose or prevent atherosclerosis are provided herein. In particular, it has been found that methylene blue injected intravenously acts as an excellent indicator because the compound targets high-risk plaque, atheroma, macrophages, and other atherosclerotic structures formed within the endothelial walls of a vessel of a subject. Because the compound ...
Low dosage serotonin 5-ht2a receptor agonist to suppress inflammation
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College
March 01, 2018 - N°20180055791

Activation of 5-ht2a receptors using agonists at surprisingly low concentrations was shown to potently inhibit tnf-α-induced inflammation in multiple cell types. Significantly, proinflammatory markers were also inhibited by the agonist, (r)-doi, even many hours after treatment with tnf-α. With the exception of a few natural toxins, no current drugs or small molecule therapeutics ...
Compositions and methods for treating and preventing hyperlipidemia, fatty liver, atherosclerosis and other disorders associated ...
Vanderbilt University
February 22, 2018 - N°20180050083

The present invention relates to compositions and methods for treating diseases associated with dyslipidemia, including hypercholesterolemia, hypertriglyceridemia, steatohepatitis, atherosclerosis, obesity, hyperglycemia, metabolic syndrome, and related aspects of and conditions associated with metabolic syndrome. The compositions and methods disclosed herein are useful for regulating the lipid balance (lipid homeostasis) in a subject. Compositions and methods including a nuclear transport modifier may ...
Compositions and methods for treating retinal degradation
University Of Kentucky Research Foundation
February 15, 2018 - N°20180044327

The present disclosure relates to compounds, compositions, and methods useful for treating retinal damage and/or retinal degradation/retinal degeneration, for inhibiting inflammasome activation by alu rna associated with a cell, for reducing atp-induced permeability of a cell, for reducing an amount of mitochondrial reactive oxygen species in a cell, and for reducing an amount of mitochondrial reactive oxygen species ...
N-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamides and n-(4- hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamides and ...
Pimco 2664 Limited
February 08, 2018 - N°20180037544

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain substituted n-(4-hydroxy-4-methyl-cyclohexyl)-4-phenyl-benzenesulfonamide and n-(4-hydroxy-4-methyl-cyclohexyl)-4-(2-pyridyl)benzenesulfonamide compounds (collectively referred to herein as hmc compounds) that are useful, for example, in the treatment of disorders (e. G., diseases) including, inflammation and/or joint destruction ...
Biomarker for diagnosis of moyamoya disease
Samsung Life Public Welfare Foundation
February 01, 2018 - N°20180030535

Provided are a biomarker composition for the diagnosis of moyamoya disease, including caveolin-1, a kit for the diagnosis of moyamoya disease, a method of providing information for moyamoya disease diagnosis, and a method of screening a moyamoya disease therapeutic agent. According to the present disclosure, specific treatment for moyamoya disease is possible by distinguishing the disease from atherosclerosis, which is ...
Mixture of purified sods of plant origin
Bionov
February 01, 2018 - N°20180030421

The present invention relates to an original and specific mixture of purified superoxide dismutases (sods) of plant origin, characterised in that said mixture is essentially made up of three superoxide dismutases: a manganese superoxide dismutase, a copper and zinc superoxide dismutase and an iron superoxide dismutase provided in two isoforms, which can be obtained from an extract of the hybrid ...
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Use of biocompatible microdroplets for the treatment of atherosclerosis, heart disease and stroke
February 01, 2018 - N°20180028443

A pharmacologically acceptable emulsion of biocompatible solvent microdroplets is provided for treating atherosclerosis, heart disease and stroke. Intravenous administration of the biocompatible solvent microdroplets enables the microdroplets to bind and dissolve free cholesterol, cholesterol esters or other fatty compounds within the plaque. A high level of selectivity is ensured from energy principals, by designing the microdroplets to have a low ...
Chimeric and humanized anti-histone antibodies
Immunomedics, Inc.
January 25, 2018 - N°20180022796

The present invention concerns chimeric or humanized antibodies or antigen-binding fragments thereof that comprise specific cdr sequences, disclosed herein. Preferably, the antibodies or fragments comprise specific heavy and light chain variable region sequences disclosed herein. More preferably, the antibodies or fragments also comprise specific constant region sequences, such as those associated with the ng1m1,2 or km3 allotypes. The antibodies ...
Small-molecule inhibitors targeting discoidin domain receptor 1 and uses thereof
Guangzhou Institutes Of Biomedicine And Health, Chinese Academy Of Sciences
January 25, 2018 - N°20180022730

Compounds of formula (i), their pharmaceutically acceptable salts and stereoisomers thereof, as well as application in effectively inhibiting the enzymatic activity of discoidin domain receptor 1 and can be used as new therapeutic agents for preventing and treating e. G. Inflammation, liver fibrosis, kidney fibrosis, lung fibrosis, skin scar, atherosclerosis, and cancer. The compound of formula i is: wherein the variables ...
Compositions and methods for treatment of intracellular damage and bacterial infection
Bioincept, Llc
January 25, 2018 - N°20180021401

Pre-implantation factor (pif) may be used to treat intracellular damage. Aspects of the invention are directed to a method of treating intracellular damage comprising administering pif to a subject in need thereof. Some aspects may be directed to methods of increasing cytokine secretion in response to intracellular damage comprising administering pif to a subject in need thereof. The intracellular damage ...
Flip - a selective molecular target of senescent cells
Bioventures, Llc
January 25, 2018 - N°20180021323

The present invention relates to modulators of flip protein and their method of use in the treatment and prevention of diseases and pathologies related to accumulation of senescent cells during aging, such as cancer, chronic obstructive pulmonary disease (copd), osteoarthritis, atherosclerosis, neurodegenerative diseases, diabetes, and many others. The present invention also relates to pharmaceutical compositions containing these compounds as well ...
Inhibitors of trka kinase
Gvk Biosciences Private Limited
January 11, 2018 - N°20180009781

The present invention is directed to the compounds of formula i which are inhibitors of tropomyosin-related kinase a (trka): formula (i) or steroisomers, tautomers or a pharmaceutically acceptable salts, metabolites, isotopes, solvates or prodrugs thereof, wherein, ra, rb, rc, rd, r1, r2, l and het-ar are as defined herein. These compounds can be used for the preventive and/or therapeutic ...
Therapeutic use for alpha1 proteinase inhibitor in hematopoiesis
The Institute For Human Genetics And Biochemistry
January 04, 2018 - N°20180003699

A previously unrecognized fundamental property of α1pi is to regulate the phenotypic composition of circulating and tissue-associated cells derived from hematopoietic stem cells. The present invention comprises screening for various unmodified and modified α1pi's which are useful in the treatment of abnormalities in the number of cells of myeloid or lymphoid lineage that are associated with ...
Fas and drs are novel molecular targets of senescent cells
Bioventures, Llc
January 04, 2018 - N°20180002431

The present invention relates to modulators of fas and drs and their method of use in the treatment and prevention of diseases and pathologies related to accumulation of senescent cells during aging, such as cancer, chronic obstructive pulmonary disease (copd), osteoarthritis, atherosclerosis, neurodegenerative diseases, diabetes, and many others. The present invention also relates to pharmaceutical compositions containing these compounds as ...
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