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Atherosclerosis

Atherosclerosis-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Processes for the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[...
Arena Pharmaceuticals, Inc.
June 08, 2017 - N°20170159088

The present invention relates to processes and intermediates useful in the preparation of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid of formula (ia) and salts thereof, an s1p1 receptor modulator that is useful in the treatment of s1p1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, ...
Trka kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme Corp.
June 08, 2017 - N°20170158698

The present invention is directed to substituted five membered heteroaryl benzamide compounds of formula (i) (formula (i)) which are tropomyosin-related kinase (trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal ...
Novel crystalline form of 5-chloro-n-(methyl)thiophene-2-carboxamide methanesulfonate and pharmaceutical composition comprising same
Legochem Biosciences,inc.
June 01, 2017 - N°20170152251

The present invention relates to a novel crystalline form of 5-chloro-n-({(5s)-2-oxo-3-[4-(5,6-dihydro-4h-[1,2,4]triazin-1-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thiophene-2-carboxamide methanesulfonate and a pharmaceutical composition containing the same. The novel crystalline form of a compound according to the present invention exhibits excellent stability even in high-temperature and humidity environments, and thus can be ...
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Crystalline forms and processes for the preparation of cannabinoid receptor modulators
Children's Hospital Medical Center
May 25, 2017 - N°20170144993

The present invention relates to crystalline forms of (1as,5as)-2-(4-oxy-pyrazin-2-yl)-1a,2,5,5a-tetrahydro-1h-2,3-diaza-cyclopropa[a]pentalene-4-carboxylic acid ((s)-1-hydroxymethyl-2,2-dimethyl-propyl)-amide (compound 1) and pharmaceutical compositions thereof that modulate the activity of the cannabinoid cb2 receptor and are therefore useful in the treatment of cb2 receptor-mediated disorders, for example, osteoarthritis; pain; hyperalgesia; allodynia; inflammatory ...
Organic compositions to treat apoc3-related diseases
Arrowhead Pharmaceuticals, Inc.
May 18, 2017 - N°20170137814

The present disclosure relates to compositions and methods for treating apoc3-related diseases such as: hypertriglyceridemia (e. G., type v hypertriglyceridemia), abnormal lipid metabolism, abnormal cholesterol metabolism, atherosclerosis, hyperlipidemia, diabetes, including type 2 diabetes, obesity, cardiovascular disease, and coronary artery disease, among other disorders relating to abnormal metabolism or otherwise, using a therapeutically effective amount of a rnai agent to apoc3.
Anti-glycation methods and compositions
Core Intellectual Properties Holdings, Llc
May 18, 2017 - N°20170136050

The present invention comprises compositions that provide anti-glycation activity comprising a mineral extract composition or a mogroside/mineral extract composition or a mogroside composition. Such compositions are useful for methods of preventing, treating and inhibiting the effects of glycation in the body. The methods of the present invention comprise use of anti-glycation composition for the treatment and prevention of glycation ...
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Method for suppressing glucagon secretion of an sglt2 inhibitor
Astrazeneca Ab
May 18, 2017 - N°20170135981

Methods are provided for avoiding an increase in glucagon secretion associated with the administration of a sodium glucose co-transporter 2 (sglt2) inhibitor via the co-administration of a dipeptidyl peptidase iv (dpp iv) inhibitor. Additionally, methods are provided for normalizing the glucagon secretion associated with the administration of a sodium glucose co-transporter 2 (sglt2) inhibitor via the co-administration of a dipeptidyl peptidase iv (...
Method of treating hyperlipidemia and atherosclerosis with mir-30c
The Research Foundation For The State University Of New York
May 04, 2017 - N°20170121713

This disclosure provides a novel role for microrna (mir) regulation of lipid metabolism via the mtp pathway, leading to reductions in apob secretion and blood lipid levels. Mir regulation of the mtp pathway is shown herein to reduce hyperlipidemia and atherosclerosis in vivo. Therefore, inhibition of mtp expression and activity by mir regulation is identified as a new therapeutic target ...
Pharmaceutical compositions for substituted quinazolinones
Resverlogix Corp.
May 04, 2017 - N°20170119767

The present disclosure relates to novel solid pharmaceutical formulations and process for their preparation. The present disclosure also provides, in part, methods of using the pharmaceutical formulations for regulating the expression of apolipoprotein a-i (apoa-i), and their use for the treatment and prevention of cardiovascular disease and related disease states, including cholesterol- or lipid-related disorders, such as, for example, atherosclerosis.
Biopolymer-encapsulated glycosyl transferase inhibitor compositions and methods for treating diabetes and cardiac indications
The Johns Hopkins University
May 04, 2017 - N°20170119683

The present invention relates to compositions comprising a biopolymer-encapsulated glycosyltransferase inhibitor and methods for treating and reducing a symptom of atherosclerosis or cardiac hypertrophy and/or diabetes using said compositions.
Portable, rapid, and inexpensive diagnostic tests for cardiac disease risk
The Johns Hopkins University
April 27, 2017 - N°20170115228

Cardiac disease is the world's leading cause of death. Cardiac disease's pathogenesis is largely attributed to cholesterol, predominantly carried by low-density lipoproteins (ldl). However, recent research has found that oxidized-ldl is significantly more potent in the initiation and development of atherosclerosis. Tests for both cholesterol and ox-ldl tests are lab-based and expensive. With every third american at risk for cardiac ...
Trka kinase inhibitors, compositions and methods thereof
Msd R & D (china) Co., Ltd.
April 27, 2017 - N°20170114071

The present invention is directed to six membered heteroaryl benzamide compounds of formula (i), which are tropomyosin-related kinase (trk) family protein pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (ngf) receptor trka.
Trka kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme Corp.
April 27, 2017 - N°20170114056

The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (i) which are tropomyosin-related kinase (trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve ...
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Therapeutic agent for dyslipidemia
Kowa Company, Ltd.
April 27, 2017 - N°20170112811

The present invention addresses the problem of providing a pharmaceutical combination composition and drug combinations for the prevention and/or treatment of dyslipidemic conditions such as atherosclerosis, hypercholesterolemia, low hdl blood disease in mammals including humans. A pharmaceutical composition for the prevention and/or treatment of dyslipidemia, etc. Which comprises (a) a compound represented by the general formula (1) (in the ...
Solid formulations containing omega-3 and resveratrol
Sigma-tau Industrie Farmaceutiche Riunite S.p.a.
April 27, 2017 - N°20170112791

The present application relates to invention a solid composition comprising omega-3 polyunsaturated fatty acids (n-3 pufa), or their alkyl esters, and resveratrol, adsorbed on an inert substrate and wherein the recovery of omega-3 is at least 96% after 6 months at 25° c. The composition according to the present invention can be formulated as food supplement or medicament for preventing or treating ...
Trka kinase inhibitors, compositions and methods thereof
Merck Sharp & Dohme Corp.
April 20, 2017 - N°20170107204

The present invention is directed to a bicyclic heteroaryl benzamide compounds of formula (i) which are tropomyosin-related kinase (trk) family protein kinase inhibitors, and hence are useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve ...
Urea compounds and their use as enzyme inhibitors
Merck Sharp & Dohme Corp.
April 13, 2017 - N°20170101381

Or a pharmaceutically acceptable salt or derivative thereof. The compound may be used in the treatment or prevention of a disorder selected from appetite regulation, obesity, metabolic disorders, cachexia, anorexia, pain, inflammation, neurotoxicity, neurotrauma, stroke, multiple sclerosis, spinal cord injury, parkinson's disease, levodopa-induced dyskinesia, huntington's disease, gilles de la tourette's syndrome, tardive dyskinesia, dystonia, amyotrophic lateral sclerosis, alzheimer's disease, epilepsy, ...
Compositions and methods for the treatment of atherosclerotic cardiovascular diseases with pde4 modulators
Celgene Corporation
March 30, 2017 - N°20170087129

Provided herein are methods of treating, preventing or managing atherosclerosis by administering a pde4 modulator. Pharmaceutical compositions, dosage forms, and kits suitable for use in methods are also provided.
Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use
The Board Of Regents Of The University Of Oklahoma
March 09, 2017 - N°20170066800

The presently disclosed inventive concept(s) include inhibitors of antiplasmin cleaving enzyme (apce) and fibroblast activation protein alpha (fap) which can be used in various therapies related to disorders of fibrin and α2-antiplasmin and abnormal cell proliferation. The presently disclosed inventive concept(s) also include substrates of apce and fap, which may be used, for example, in screening ...
Composition for imaging atherosclerosis and method for diagnosing atherosclerosis by using same
Seoul National University R&db Foundation
March 09, 2017 - N°20170065730

The present disclosure relates to a composition for imaging atherosclerosis and a method for diagnosing atherosclerosis using the same. The composition for imaging atherosclerosis according to the present disclosure shows excellent atherosclerosis diagnosis accuracy, enables diagnosis of atherosclerosis even for a person with diseases of glucose metabolism such as diabetes and enables effective diagnosis even for atherosclerosis occurring in the ...
High throughput biochemical fluorometric method for measuring hdl redox activity
The Regents Of The University Of California
March 02, 2017 - N°20170059595

In various embodiments, a new, robust fluorometric cell-free biochemical assay that measures hdl redox activity (hra) is provided. In certain embodiments the assay is based on the oxidation of the fluorochrome amplex® red in the presence of hrp. Hra correlated with previously validated cell-based (r=0. 47, p<0. 001) and cell-free assays (r=0. 46, p<0. 001). Hra measurement identified samples ...
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