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|| List of recent Aspergillus-related patents
|Method for producing terpenes|
The present invention relates to a method for producing terpenes in fungi, wherein a terpene biosynthetic gene cluster having terpene biosynthetic genes and regulatory regions operably linked to said genes is activated. The invention relates also to a terpene biosynthetic gene cluster and regulatory regions of such terpene biosynthetic gene cluster usable is production of terpenes, use of regulator for regulating the terpene production and use of aspergillus nidulans fgsc a4 for producing terpenes.
|Expression of catalase in trichoderma|
The invention provides methods for expression of a catalase enzyme in a trichoderma host cell. In one embodiment, the catr gene from aspergillus niger is expressed in trichoderma reesei, resulting in improved yields of catalase enzyme in comparison with expression of catr in a.
|Oleyl phosphocholine for the treatment of mycosis|
The present invention relates to the use of oleyl phosphocholine (c18:1-pc), or olpc,for the treatment of mycosis, and especially for the treatment of mycosis such as mycosis caused by pathogens belonging to a genus selected from the group consisting of candida, aspergillus, fusarium, cryptococcus, microsporum, sporothrix, trichophyton and scedosporium, for example, candida albicans, candida parapsilosis, candida glabrata, candida krusei, aspergillus fumigatus, aspergillus niger, aspergillus terreus, fusarium solani, scedosporium prolifacans, cryptococcus neoformans, microsporum canis, sporothrix schenkii, trichophyton rubrum, trichophyton mentagrophytes, aspergillus fumigatus, fusarium oxysporum.. .
|Method of using alpha-amylase from aspergillus clavatus for saccharification|
A fungal α-amylase is provided from aspergillus clavatus (acamyl). Acamyl has an optimal ph of 4.5 and is operable at 30-75° c., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction.
|Method for the production of duplication and translocation of any region in the chromosome of aspergillus|
The present invention relates to a transformant of the fungus belonging to aspergillus wherein a transformation marker gene with deficiency of a terminal part at the 5′ or 3′ end of its coding region is integrated into an outside of a target region in a chromosome of the fungus subject to duplicated translocation, and a transformation marker gene with deficiency of a terminal part at the 3′ or 5′ end of its coding region is integrated into an outside of a region in another chromosome of the fungus to be replaced with the target region.. .
|Cross protective epitopes of aspergillus fumigatus and candida albicans|
A complex comprising a class ii hla-drb1*03 or class ii hla-drb1*13 molecule bound to a peptide, wherein the peptide comprises the amino acid sequence htytidwtkdavtws or a portion thereof, or a variant of the given amino acid sequence or portion wherein the side chains of one or two or three or four or five or six or seven of the amino acid residues are altered, wherein the peptide comprising the portion, or variant, is capable of binding hla-drb1*03 and/or hla-drb1*13. The complex may be used to select aspergillus and candida antigen-specific t cells.
|Methods and compositions for modified ethanol inducible promoter systems|
The present invention provides nucleic acid molecules comprising one or more nucleotide sequences selected from the group consisting of the nucleotide sequence of seq id no:1, seq id no:3, seq id no:4, seq id no:5, seq id no:6, seq id no:7, seq id no:8, and/or seq id no:10 that can be operably linked to a promoter, thereby making the promoter inducible by a chemical compound that can induce the expression of the alcohol dehydrogenase system of aspergillus nidulans. Methods for making an inducible promoter and for making the expression of a nucleotide sequence of interest inducible are also provided.
|Method of improving the activity of cellulase enzyme mixtures in the saccharification (ligno)cellulosic material|
The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: chrysosporium, thielavia, talaromyces, thermomyces, thermoascus, neurospora, aureobasidium, filibasidium, piromyces, corynascus, cryplococcus, acremonium, tolypocladium, scytalidium, schizophyllum, sporotrichum, penicillium, gibberella, myceliophthora, mucor, aspergillus, fusarium, humicola, trichoderma, and talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms..
|Aspergillus containing beta-glucosidase, beta-glucosidases and nucleic acids encoding the same|
A novel microorganism is provided named aspergillus saccharolyticus. Further, beta-glucosidase enzymes encoded by said microorganism are provided, and the use thereof in the degradation of lignocellulosic material.
|Enzyme preparation from koji fermentation|
The invention provides an enzyme preparation obtainable from a koji fermentation, wherein the koji fermentation comprises mushrooms fermented with aspergillus. The invention further relates to an enzyme preparation obtainable from the fermentation of a mixture of mushrooms and cereal with aspergillus, to a process of producing the enzyme preparation, and to the use of the preparation..
|Filamentous fungi with inactivated protease genes for altered protein production|
The invention relates to a filamentous fungal cell (e.g., aspergillus sp.) comprising at least one inactivated protease gene chosen from apsb, a homolog of apsb, cpsa, a homolog cpsa, and combinations thereof. Nucleic acids and methods for making the inactivated mutant filamentous fungal cells are provided as well as methods for using the cells for the altered production of endogenous or heterologous proteins of interest..
|Diagnostic assays for the detection and identification of aspergilli|
Three important species of aspergillus, a. Fumigatus, a.
|Compounds and methods for treating candidiasis and aspergillus infections|
The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a candida or aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an aspergillus infection.. .
|Oligonucleotides useful in methods for detecting and characterizing aspergillus fumigatus|
Methods for using oligonucleotides in the detection of aspergillus fumigatus are disclosed. The oligonucleotides of the invention have nucleotide sequences derived from the gene encoding the cytochrome p450 14 alpha-sterol demethylase (the cyp51a protein) of aspergillus fumigatus.
|Method for the production of erythritol|
The invention relates to a method for the production of erythritol, in which erythrose is reduced to erythritol using a nadph-specific enzyme, wherein the enzyme is an erythrose reductase which was isolated from the group of saprophytes selected from the strains of hypocrea, gibberella, aspergillus and penicillium. Hereby it is possible to produce erythritol in high yields..
|Method for producing a large region duplication of aspergillus chromosome|
Disclosed is a technique which is for duplicating across a wide region any large region on a chromosome of a fungus belonging to aspergillus strain, and which enables the stable and systematic acquisition of a previously un-acquirable fungus belonging to the aspergillus strain having novel traits. Disclosed is a transformant wherein a transformation marker gene sequence is arranged on the outside of terminals (5′, 3′) of a region so as to sandwich an arbitrary region of a chromosome, and chromosome duplication has taken place by means of homologous recombination after double strand breakage generated in a homologous region inside the gene.
|Protease enzymes for increased protein digestion rate and absorption and methods of using the same|
A food supplement comprises at least one protease enzyme selected from (i) cas #9001-92-7, iub 126.96.36.199 protease from aspergillus; (ii) cas #9001-92-7, iub 188.8.131.52 protease from bacillus; (iii) cas #9001-61-0, iub 184.108.40.206 protease from aspergillus; (iv) cas #9074-07-1, iub 220.127.116.11 protease from aspergillus; (v) cas #9073-78-3, iub 18.104.22.168 protease from aspergillus; (vi) cas #9025-49-4, iub 22.214.171.124 protease from aspergillus; and (vii) combinations thereof. The food supplement may further comprise a protein, a stabilizer, a matrix modifier, a carrier, a preservative, a bulking agent, a dessicant, an emulsifier, an enzyme coating, or combinations thereof.
|Methods of inducing leukemia and lymphomas and detecting susceptibility to leukemia/ lymphoma|
A diagnostic test is described using aspergillus flavus fungal cultures, ebv or their combination to induce leukemic cell surface markers in mononuclear cells of former or current leukemia patients. Detection of the leukemic transformation by means known in the art, identified patients who have or had leukemia, or potentially may become leukemic.
|Enhanced citric acid production in aspergillus with inactivated asparagine-linked glycosylation protein 3 (alg3), and/or increased laea expression|
Provided herein are fungi, such as aspergillus niger, having a dolichyl-p-man:man(5)glcnac(2)-pp-dolichyl mannosyltransferase (alg3) gene genetic inactivation, increased expression of a loss of aflr expression a (lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain.
Disclosed is a glyceroglycolipid lipase which is highly safe, can hydrolyze a neutral fat, a glycerophospholipid or a glyceroglycolipid at about ph 6, is thermally stable to some extent, can hydrolyze lecithin, cannot hydrolyze lysolecithin, can rise a bread when used singly in the production of the bread, and has no unpleasant odor. Specifically disclosed is a glyceroglycolipid lipase derived from a filamentous bacterium aspergillus japonicus..
Provided is a glucose sensor that is capable of measuring a glucose concentration even in the case where aspergillus oryzae type fad-gdh (flavin adenine dinucleotide-glucose dehyrogenase) and a ruthenium compound are used in combination. The glucose sensor includes an insulative substrate, an electrode system having a working electrode and a counter electrode provided on the substrate, and a reagent layer provided on the electrode system, wherein the reagent layer contains aspergillus oryzae type fad-gdh, a ruthenium compound, and pms (phenazine methosulfate)..
|Lateral flow device for diagnosing microbial infections|
Fungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carries with it a high mortality.
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Aspergillus topics: Aspergillus, Nucleotide, Nucleic Acid, Nucleic Acids, Lovastatin, Aflatoxins, Alcohol Dehydrogenase, Dehydrogenase, Chemical Compound, Citric Acid, Polynucleotide, Polypeptide, Carbohydrates, Complex Carbohydrate, Metabolite
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