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Aspergillus patents



      

This page is updated frequently with new Aspergillus-related patent applications.




Date/App# patent app List of recent Aspergillus-related patents
06/16/16
20160169892 
 Monoclonal antibodies, hybridoma cell lines, methods and assays for detecting fungal phytase patent thumbnailMonoclonal antibodies, hybridoma cell lines, methods and assays for detecting fungal phytase
This invention relates to the field of immunology and more specifically relates to antiphytase monoclonal antibodies and immunoassay methods for the detection of a phytase from or derived from aspergillus niger (phya2) phytase, in particular, eh10a, fa7, af9a and cc1 antiphytase antibodies. The invention further relates to hybridoma cell lines that produce antiphytase monoclonal antibodies..

05/19/16
20160138053 
 Production  tagatose patent thumbnailProduction tagatose
A method for producing tagatose comprises: a) performing epimerization of fructose using hexuronate c4-epimerase to obtain an epimerized product comprising tagatose; b) purifying the epimerized product; and c) crystallizing the purified epimerized product. The hexuronate c4-epimerase is an enzyme derived from thermotoga maritima, thermotoga neapolitana, thermotoga thermarum or mutants thereof.
Cj Cheiljedang Corporation


05/19/16
20160137693 
 Peptide nucleic acid probe (pna), kit and  detection of aspergillus fumigatus and applications thereof patent thumbnailPeptide nucleic acid probe (pna), kit and detection of aspergillus fumigatus and applications thereof
The present invention also includes the development of the kit of detection and respective procedure for the aspergillus fumigatus identification in clinical samples.. .

04/28/16
20160115509 
 Trichoderma reesei host cells expressing a glucoamylase from aspergillus fumigatus and methods of use thereof patent thumbnailTrichoderma reesei host cells expressing a glucoamylase from aspergillus fumigatus and methods of use thereof
Fungal glucoamylases from aspergillus fumigatus—expressed in trichoderma reesei host cells (afgatr) are provided. Trichoderma reesei host cells express afgatrs at higher, or at least comparable, levels to natively expressed afga aspergillus fumigatus.
Danisco Us Inc.


04/21/16
20160108448 
 Process for producing high glucose compositions by simultaneous liquefaction and saccharification of starch substrates patent thumbnailProcess for producing high glucose compositions by simultaneous liquefaction and saccharification of starch substrates
Fungal glucoamylases from aspergillus fumigatus that are expressed in trichoderma reesei host cells (afgatr) are provided. Afgatrs, including afga1tr and afga2tr, exhibit high activity at elevated temperatures and at low ph, so afgatrs can be used efficiently in a simultaneous liquefaction and saccharification process in the presence of alpha amylase, such as aspergillus kawachii alpha-amylase (akaa).

04/07/16
20160097063 
 Production of enantiopure alpha-hydroxy carboxylic acids from alkenes by cascade biocatalysis patent thumbnailProduction of enantiopure alpha-hydroxy carboxylic acids from alkenes by cascade biocatalysis
The invention provides compositions comprising an alkene epoxidase and a selective epoxide hydrolase, such as a recombinant microorganism comprising a first heterologous nucleic acid encoding an alkene epoxidase and a second heterologous nucleic acid encoding a selective epoxide hydrolase. Exemplary alkene epoxidases include styab, while exemplary selective epoxide hydrolases include epoxide hydrolases from sphingomonas, solanum tuberosum, or aspergillus.
National University Of Singapore


02/18/16
20160047809 
 Immunogenic antigens from aspergillus fumigatus patent thumbnailImmunogenic antigens from aspergillus fumigatus
The present invention provides the in-vitro use of at least one in-vivo-target antigen of aspergillus fumigatus for selective activation, detection and/or analysis of aspergillus fumigatus specific cd4+ t cells in a sample comprising cells, wherein said at least one in-vivo-target antigen reveals an immune reactivity characterized by i) the in vivo existence of antigen-specific t cells comprising more than 60% memory t cells and ii) said antigen-specific t cells further comprise t cells able to produce ifn-gamma upon stimulation at a frequency between 15% and 80% and/or il17 upon stimulation at a frequency between 5% and 30%. Said at least one in-vivo-target antigen may be selected from the group consisting of antigens scw4, pst1, shm2, glit and tpia or fragments thereof.
Leibniz Institute For Natural Product Research And Infection Biology - Hans Knoll Institute


02/18/16
20160046967 
 Enhanced itaconic acid production in aspergillus with increased laea expression patent thumbnailEnhanced itaconic acid production in aspergillus with increased laea expression
Fungi, such as aspergillus niger, having a dolichyl-p-man:man(5)glcnac(2)-pp-dolichyl mannosyltransferase (alg3) gene genetic inactivation, increased expression of a loss of aflr expression a (laea), or both, are described. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain.
Battelle Memorial Institute


02/11/16
20160040202 
 Method of using alpha-amylase from aspergillus fumigatus and pullulanase for saccharification patent thumbnailMethod of using alpha-amylase from aspergillus fumigatus and pullulanase for saccharification
A fungal alpha-amylase is provided from aspergillus fumigatus (afamy1). Afamy1 has an optimal ph of 3.5 and is operable at 30-75 degrees c., allowing the enzyme to be used in combination with a glucoamylase and a pullulanase in a saccharification reaction.
Danisco Us Inc.


02/04/16
20160032338 
 Method of using alpha-amylase from aspergillus fumigatus and isoamylase for saccharification patent thumbnailMethod of using alpha-amylase from aspergillus fumigatus and isoamylase for saccharification
A fungal alpha-amylase is provided from aspergillus fumigatus (afamyl). Afamyl has an optimal ph of 3.5 and is operable at 30-75 degrees c., allowing the enzyme to be used in combination with a glucoamylase and an isoamylase in a saccharification reaction.
Danisco Us Inc.


01/14/16
20160010128 

Method of using alpha-amylase from aspergillus terreus and pullulanase for saccharification


A fungal alpha-amylase is provided from aspergillus terreus (atamyl). Atamyl has an optimal ph of 4.5 and is operable at 30 75 degrees c., allowing the enzyme to be used in combination with a glucoamylase and a pullulanase in a saccharification reaction.
Danisco Us Inc.


01/07/16
20160002692 

Expression of beta-glucosidases for hydrolysis of lignocellulose and associated oligomers


The present invention provides for heterologous expression of beta-glucosidase (bgl) polypeptides encoded by humicola grisea, candida wickerhamii, aspergillus aculeatus, aspergillus oryzae, penicillium decumbens, chaetomium globosum, neocallimastix frontalis, debaryomyces hansenii, kluyveromyces marxianus, or phytophthora infestans in host cells, such as the yeast saccharomyces cerevisiae. The expression in such host cells of the corresponding genes, and variants and combinations thereof, result in improved specific activity of the expressed bgl.
Lallemand Hungary Liquidity Management Llc


12/31/15
20150376668 

Method of using alpha-amylase from aspergillus terreus and isoamylase for saccharification


A fungal alpha-amylase is provided from aspergillus terreus (atamy1). Atamy1 has an optimal ph of 4.5 and is operable at 30 75 degrees c., allowing the enzyme to be used in combination with a glucoamylase and an isoamylase in a saccharification reaction.
Danisco Us Inc.


12/24/15
20150366845 

Pharmaceutical composition for diseases caused by pathogenic microorganisms such as aspergillus


An object is to provide means for precisely treating pneumonia caused by intracellular parasite, protozoa, and/or fungus. A pharmaceutical composition for pneumonia, comprising a compound represented by the following general formula (1) as an active ingredient: (in the formula, r represents a halogen atom or a hydrogen atom, and x represents a halogen atom.).
Nihon Nohyaku Co., Ltd.,


12/17/15
20150361471 

Production of lysergic acid by genetic modification of a fungus


The present invention provides a method of producing lysergic acid and other ergot alkaloids by genetic modification of a fungus. A strain of fungus comprising aspergillus fumigatus (a.
West Virginia University


12/17/15
20150361455 

Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof


A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (pal) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (c4h) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-coa ligase (4cl) produces 4-coumaroyl coa from said 4-coumaric acid, and resveratrol synthase (vst) produces said resveratrol from said 4-coumaroyl coa, or in which l-phenylalanine- or tyrosine-ammonia lyase (pal/tal) produces 4-coumaric acid, 4-coumarate-coa ligase (4cl) produces 4-coumaroyl coa from said 4-coumaric acid, and resveratrol synthase (vst) produces said resveratrol from said 4-coumaroyl coa. The micro-organism may be a yeast, fungus or bacterium including saccharomyces cerevisiae, e.
Evolva Sa


12/10/15
20150353503 

Indazole derivatives and uses thereof


The present invention provides novel compounds (e.g., compounds of formula (i)), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits comprising the inventive compounds, or compositions thereof, for treating and/or preventing a fungal or protozoan infection, inhibiting the activity of a fungal or protozoan enzyme, killing a fungus or protozoon, or inhibiting the growth of a fungus or protozoon.
Massachusetts Institute Of Technology


11/05/15
20150315621 

One-pot fermentation process for simvastatin production


Simvastatin is a drug used in treatment of hypercholesterolemia because of its inhibitory activities towards cholesterol biosynthesis. The technology described herein is a novel method of biosynthesizing simvastatin directly from an engineered microbial host (such as saccharomyces cerevisiae) using an engineered biosynthetic pathway.
The Regents Of The University Of California


10/29/15
20150305376 

Novel aspergillus oryzae cj 1354 isolated from the korean traditional meju, manufacturing a rice hot pepper paste using the same and the rice hot pepper paste prepared by the method


The present invention relates to novel aspergillus oryzae cj 1354, isolated and identified from korean traditional meju, exhibiting high enzymatic activities in rice as a substrate, a method for preparing a rice hot pepper paste having an improved flavor using the same, and a rice hot pepper paste prepared by the method. Specifically, the method comprises a process in which rice milled to have a certain whiteness is treated with high-pressure steam having a pressure of 2.0-4.0 kgf/cm2 in a steaming step to control the viscosity and water content of the steamed rice to thereby prevent agglomeration from occurring during transfer of the steamed rice.
Cj Cheiljedang Corporation


10/22/15
20150299680 

Cloning, expression and use of acid phospholipases


The invention relates to a dna sequence, which codes for a polypeptide having phospholipase activity essentially without lipase activity, characterized in that the dna sequence is selected from a) dna sequences that comprise a nucleotide sequence according to seq id no: 1, b) dna sequences that comprise the coding sequence according to seq id no: 1, c) dna sequences that code for the protein sequence according to seq id no: 2, d) dna sequences that are coded for by the plasmid ppl3940-topo2.5 with the restriction map according to fig. 7, which is deposited under accession number dsm 22741, e) dna sequences that hybridize under stringent conditions with one of the dna sequences according to a), b), c) or d), f) dna sequences that are related to the dna sequences according to a), b), c), d) or e) due to the degeneration of the genetic code, and g) complementary strands to the sequences according to a) to f), wherein the dna sequence is preferably derived from aspergillus, and more preferably from aspergillus fumigatus, and a polypeptide having phospholipase activity essentially without lipase activity selected from a) a polypeptide which is coded for by the coding part of a dna sequence as defined above, b) a polypeptide having the sequence according to seq id no: 2 or a sequence derived therefrom, which may be obtained by substitution, addition, deletion of one or more amino acid(s), c) a polypeptide having a sequence that has at least 83% identity with the amino acids 1 to 299 of seq id no: 2, d) a polypeptide which is coded for by a nucleic acid sequence which hybridizes under stringent conditions with (i) nucleotides 55 to 1106 of seq id no: 1, (ii) the cdna sequence contained in nucleotides 55 to 1106 of seq id no: 1, (iii) a partial sequence of (i) or (ii) composed of at least 100 nucleotides, or (iv) a complementary strand of (i), (ii) or (iii), e) a variant of the polypeptide having seq id no: 2, comprising a substitution, deletion and/or insertion of one or more amino acid(s), f) allelic variants to amino acid sequences a) to e)..
Ab Enzymes Gmbh


09/10/15
20150252340 

Compositions and methods of us


The present compositions and methods relate to a beta-glucosidase from aspergillus terreus, polynucleotides encoding the beta-glucosidase, and methods of make and/or use thereof. Formulations containing the beta-glucosidase are suitable for use in hydrolyzing lignocellulosic biomass substrates..
Danisco Us Inc.


08/27/15
20150240223 

Method of using alpha-amylase from talaromyces emersonii for saccharification


A fungal alpha amylase is provided from talaromyces emersonii (teamy1), along with variants of the same. Teamy1 has an optimal ph of 3.5 and is operable over a temperature range of at least 30 75° c., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction.
Danisco Us Inc.


08/20/15
20150232901 

Method of using alpha-amylase from aspergillus clavatus and isoamylase for saccharification


A fungal alpha-amylase is provided from aspergillus clavatus (acamy1). Acamy1 has an optimal ph of 4.5 and is operable at 30-75° c., allowing the enzyme to be used in combination with a glucoamylase and an isoamylase in a saccharification reaction.
Danisco Us Inc.


08/20/15
20150232899 

Multi-enzymatic preparation containing the secretome of an aspergillus japonicus strain


The invention relates to a multi-enzymatic preparation containing the secretome of the cncm i-4639 strain of aspergillus japonicus. This secretome, which contains in particular cellulases and hemicellulases, can be used for the saccharification of lignocellulosic substrates, in particular in combination with the secretome of trichoderma reesei..
Universite D'aix Marseille


08/20/15
20150232892 

Enhanced citric acid production in aspergillus with inactivated asparagine-linked glycosylation protein 3 (alg3), and/or increased laea expression


Provided herein are fungi, such as aspergillus niger, having a dolichyl-p-man:man(5)glcnac(2)-pp-dolichyl mannosyltransferase (alg3) gene genetic inactivation, increased expression of a loss of aflr expression a (lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain.
Battelle Memorial Institute


08/20/15
20150230458 

Antimicrobial efficacy of an oregano oil and caprylic acid blend


The purpose of this study was to test the efficacy of an oregano extract containing carvacrol and capyrlic acid blend by screening for inhibition and by conducting a preservative efficacy test, usp 51, in skin creams. Minimum inhibitory concentrations were found for escherichia coli, staphylococcus aureus, pseudomonsas aeruginosa, streptococcus sanguinis, salmonella enterica, candida albicans, and aspergillus brasiliensis..
Kemin Industries, Inc.


08/06/15
20150218606 

Method of using alpha-amylase from aspergillus clavatus and pullulanase for saccharification


A fungal alpha amylase is provided from aspergillus clavatus (acamyl). Acamyl has an optimal ph of 4.5 and is operable at 30-75 c, allowing the enzyme to be used in combination with a glucoamylase and a pullulanase in a saccharification reaction.
Danisco Us Inc.


07/23/15
20150203855 

Aspergillus mutant strain


An aspergillus mutant strain obtained by deleting a ligd gene from an auxotrophic mutant strain of aspergillus oryzae strain aok27l.. .
Honda Motor Co., Ltd.


07/23/15
20150203833 

Aspergillus containing beta-glucosidase, beta-glucosidases and nucleic acids encoding the same


A novel microorganism is provided named aspergillus saccharolyticus. Further, beta-glucosidase enzymes encoded by said microorganism are provided, and the use thereof in the degradation of lignocellulosic material.
Clean-vantage Llc


07/23/15
20150203832 

Aspergillus mutant strain


An aspergillus mutant strain characterized in that it is an auxotrophic mutant strain of aspergillus oryzae strain aok27l.. .
Honda Motor Co., Ltd.


07/09/15
20150192581 

Lateral flow device for diagnosing microbial infections


Fungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carriers with it a high mortality.
The Johns Hopkins University


06/11/15
20150160220 

Methods to predict progression of berret's esophagus to high grade dysplasia esophageal adenocarcinoma


In some embodiments, a method for aiding prediction of the likelihood of progression from barrett's esophagus to high grade dysplasia or esophageal adenocarcinoma in a subject, is disclosed. The method can include (a) providing an oesophagal sample from said subject (b) determining if said sample stains abnormally with aspergillus oryzae lectin; (c) determining if there is a dna content abnormality in said sample; and (d) determining if there is low grade dysplasia in said sample; wherein if (b) is abnormal and (c) is abnormal and low grade dysplasia is present, then an increased likelihood of progression is determined.
Medical Research Council


06/04/15
20150152444 

Metabolically engineered cells for the production of resveratrol or an oligomeric or glycosidically-bound derivative thereof


A recombinant micro-organism producing resveratrol by a pathway in which phenylalanine ammonia lyase (pal) produces trans-cinnamic acid from phenylalanine, cinnamate 4-hydroxylase (c4h) produces 4-coumaric acid from said trans-cinnamic acid, 4-coumarate-coa ligase (4cl) produces 4-coumaroyl coa from said 4-coumaric acid, and resveratrol synthase (vst) produces said resveratrol from said 4-coumaroyl coa, or in which l-phenylalanine- or tyrosine-ammonia lyase (pal/tal) produces 4-coumaric acid, 4-coumarate-coa ligase (4cl) produces 4-coumaroyl coa from said 4-coumaric acid, and resveratrol synthase (vst) produces said resveratrol from said 4-coumaroyl coa. The micro-organism may be a yeast, fungus or bacterium including saccharomyces cerevisiae, e.
Evolva Sa


06/04/15
20150152442 

Method of using alpha-amylase from aspergillus clavatus for saccharification


A fungal α-amylase is provided from aspergillus clavatus (acamy1). Acamy1 has an optimal ph of 4.5 and is operable at 30-75° c., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction.
Danisco Us Inc.


05/21/15
20150140574 

Method for producing horseradish peroxidase recombinant protein using filamentous fungus


A modified polynucleotide has a different base sequence in at least one codon from a wild-type base sequence encoding a horseradish peroxidase polypeptide. The usage frequency of the modified codon of the polynucleotide corresponds to the codon usage frequencies of three filamentous fungal species in humicola, aspergillus, and trichoderma.
Meiji Seika Pharma Co., Ltd.


05/21/15
20150139958 

Feed composition and production same


Provided are a feed composition, which can be stored for a long time and is easily produced and adjustable in components, and which can increase the body weight and reduce a feed conversion ratio of farm animals to which the feed composition is fed, and a production method for the feed composition. In the feed composition, a liquid feed additive obtained by fermenting a carbohydrate-containing carbohydrate raw material by aspergillus is substituted for 5 to 50% on a dry matter basis of a feed raw-material..
Kirishima Highland Beer Co., Ltd.


05/07/15
20150125860 

Methods and compositions for detecting aspergillus terreus, aspergillus niger, and mycotoxins


The invention relates to a method of identifying an aspergillus terreus or an aspergillus niger fungal species in patient tissue or body fluid and to primers and probes for use in such a method.. .
Medical Service Consultation International Llc


05/07/15
20150125402 

Antimicrobial agents


Compounds are used in compositions as antimicrobial agents against microbes, such as for example, staphylococcus aureus, staphylococcus epidermidis, escherichia coli, pseudomonas aeruginosa, candida albicans, and aspergillus brasiliensis. Antimicrobial action is obtained by contact of a microorganism with at least one of the compounds of the structure (i); wherein r is a branched or straight chain, saturated or unsaturated hydrocarbyl group with zero or one double bond and a total of from 1 to 11 carbon atoms; r1 is —oh, =0 or —oc(0)ch3 and wherein the compounds of structure (i) contain a total of from 9 to 18 carbon atoms in the compounds..
Bedoukian Research, Inc.


04/30/15
20150118717 

Preparation method conducive to enhancing enzymatic activity of cellulase


A preparation method conducive to enhancing enzymatic activity of cellulase includes the steps of preparing a first inducer, preparing preculture hyphae, producing enzymes by a single strain, feeding a second inducer, and producing enzymes by co-culture strains. Main ingredients of the first inducer and the second inducer are cellulose and lactose, respectively.
Institute Of Nuclear Energy Research, Atomic Energy Council, Executive Yuan


04/02/15
20150093805 

Polypeptides having alpha-amylase and granular starch hydrolyzing activity


The present invention relates to a polypeptide having alpha-amylase activity obtained from a strain of aspergillus niger.. .
Danisco Us Inc.


01/22/15
20150025001 

Fish protein hydrolysate having a satietogenic activity, nutraceutical and pharmacological compositions comprising such a hydrolysate and obtaining same


The present invention relates to a fish protein hydrolysate containing molecules capable of exerting a satietogenic activity and of regulating food intake in humans or animals. More specifically, the protein hydrolysate according to the invention enables stimulation of the secretion of endogenous cholescystokinins (ccks) and of endogenous glucagon-like peptide 1 (glp1) molecules by intestinal cells and the supply of exogenous ccks.
Museum National D'histoire


01/15/15
20150018532 

Antibody


The invention relates to antibodies to aspergillus species and to methods of producing those antibodies. The invention also relates to the use of such antibodies in identifying the presence of the aspergillus species and to methods of treating an infection with the aspergillus species..
University Of Exeter


01/08/15
20150010676 

Acrylamide-degrading self-cloning aspergillus oryzae


Provided are self-cloning aspergillus oryzae that expresses amidase without induction culture exhibiting high amidase degradation activity, and a method for reducing acrylamide in which this self-cloning aspergillus oryzae is used. Self-cloning aspergillus oryzae, which has a gene which codes a polypeptide with a specific amino acid sequence indicated in seq id no:1, or has a base sequence hybridizable to a complementary sequence of the gene encoding seq id no:1 under stringent conditions, has a protein with amidase activity which the gene is expressed without induction culture, the process of reducing acrylamide by contact treatment with the above described self-cloning aspergillus oryzae and acrylamide-containing matter, and a method of producing reduced acrylamide food or beverage..
Ozeki Corporation


12/25/14
20140373582 

Method for producing alcohol using tree as starting material and alcohol solution obtained by same


A method is provided for the production of alcohol from trees, the method comprising a step of treating a subject tree with mother cell lyases formed through cytolysis associated with sporulation of spore-forming aerobic bacteria, thereby degrading said tree into a powdery state and obtaining a tree degradation product; a step of sterilizing said tree degradation product; a step of treating said sterilized tree degradation product with a koji fungus (aspergillus oryzae) thereby carrying out a primary fermentation; a step of adding a yeast to the fermentation broth obtained by said primary fermentation thereby carrying out a secondary fermentation; and a step of filtering the fermentation broth obtained by said secondary fermentation, wherein said mother cell lyases are obtained by culturing said spore-forming aerobic bacteria, subjecting the resultant culture medium to a starvation state, thereby converting said bacteria into endospores, and removing impurities including said endosporic bacteria from said culture medium and wherein said spore-forming aerobic bacteria are mre symbiotic bacteria.. .
Meisho Co., Ltd


12/04/14
20140356887 

Glucose dehydrogenase


Amino acid mutation(s) can be introduced to sclerotinia sclerotiorum- or aspergillus niger-derived glucose dehydrogenase to obtain a glucose dehydrogenase variant with significantly enhanced productivity in e. Coli.

11/20/14
20140342012 

Preparation and use of fish skin fermentation product


The present invention relates to a method for fermenting fish skin by using aspergillus. Also provided is a use of the fermentation liquid obtained by fermenting fish skin with aspergillus obtained from the method in inhibiting the activity of tyrosinase, inhibiting the activity of angiotensin-converting enzyme and/or improving the survival of fibroblasts..

10/16/14
20140308249 

Stabilized biocontrol water dispersible granules


The present invention provides a stabilized water dispersible granule biocontrol composition comprising at least one non-toxigenic strain of aspergillus, at least one water-soluble filler and at least one anionic surfactant.. .

10/02/14
20140296135 

Medicament for the treatment of fungal infections particularly aspergillosis


The combination of pentraxin ptx3 with antifungals is described for the treatment of fungal infections and particularly for infections caused by aspergillus fumigatus.. .

09/25/14
20140287462 

Gene inactivated mutants with altered protein production


A recombinant filamentous fungal cell (e.g. aspergillus) having one or more inactivated chromosomal genes is provided.

09/18/14
20140274882 

Methods, compositions, and kits for detection of aspergillosis


Provided herein are methods for detecting an aspergillus protease in a sample, diagnosing a subject with aspergillosis caused by an aspergillus infection based on the presence of an aspergillus protease in a sample, and methods of aspergillosis treatment that incorporate these diagnostic methods. In certain embodiments, the aspergillus protease is asp f2, and the aspergillus infection is caused a.

08/28/14
20140242085 

Methods and composition for testing, preventing, and treating aspergillus fumigatus infection


As a result of the analysis by an sst-rex method so as to identify a target molecule for treating and testing an aspergillus fumigatus infection, a ymaf1 protein has been found out, which is mainly localized in the cell wall of aspergillus fumigatus. Moreover, it has been found out that ymaf1 protein-deficient aspergillus fumigatus has reduced spore-forming ability and pathogenicity.

08/21/14
20140234914 

Aspergillus fumigatus cellulolytic enzyme compositions and uses thereof


The present invention relates to recombinant trichoderma host cells producing aspergillus fumigatus cellulolytic enzyme compositions and methods of producing and using the compositions.. .

08/07/14
20140221504 

Methods and compositions for detecting aspergillus terreus, aspergillus niger, and mycotoxins


The invention relates to a method of identifying an aspergillus terreus or an aspergillus niger fungal species in patient tissue or body fluid and to primers and probes for use in such a method.. .

08/07/14
20140220078 

Method for preparing glucans based on aspergillus niger


This invention further concerns the glucans thus obtained, compositions comprising them, and their uses. The glucans of the invention may be used as immunostimulants..

08/07/14
20140219982 

Exogenous opioid peptide-degrading enzyme


The present invention is intended to provide a means for efficiently degrades exogenous opioid peptides. Provided is an exogenous opioid peptide-degrading enzyme preparation which contains one or more components selected from the group consisting of enzyme preparations from penicillium citrinum, aspergillus oryzae, and aspergilius melleus, and exhibits a degradation activity for a wheat gluten-derived opioid peptide and a casein-derived opioid peptide..

07/31/14
20140213762 

Casein hydrolysate


A casein hydrolysate formed by controlled hydrolysis of a casein substrate by an aspergillus-derived (fugal) proteolytic preparation is described. The controlled hydrolysis employs a flavorpro-whey™ formulation and a degree of hydrolysis (% dh) of from 5% dh to 15% dh.

07/24/14
20140206058 

Systems and methods for improving stillage


Systems and methods for improving stillage are disclosed. Stillage may include either whole stillage or thin stillage.

07/17/14
20140199754 

Production of itaconic acid


The invention relates to a nucleic acid sequence encoding an itaconate transporting major facilitator superfamily transporter (mfst) gene sequence and the protein encoded thereby. Preferably said sequence is the nucleic acid that comprises the sequence of ateg_09972.1 of aspergillus terreus or homologues thereof.

07/10/14
20140193885 

Production of itaconic acid


The invention relates to a nucleic acid sequence encoding an aspergillus mitochondrial tricarboxylic acid transporter that can be used in the production of itaconic acid in micro-organisms. Preferably said transporter protein is the protein encoded by the nucleic acid which is located on a chromosome segment of a.

06/26/14
20140178884 

Method of diagnosing and treating an aspergillus species-associated condition


Disclosed herein are methods of diagnosing, monitoring and treating an aspergillus species-associated condition, such as aspergillus fumigatus (af)-associated condition, including aspergillosis, such as invasive aspergillosis (ia). Methods for diagnosing and/or monitoring an aspergillus species-associated condition, such as ia are provided.

06/05/14
20140155597 

Amidine compound or salt thereof


The purpose of the present invention is to provide a novel compound which has an anti-fungal activity on pathogenic fungi including fungi belonging to the genus candida, the genus aspergillus and the genus trichophyton and is useful as a medicinal agent. A compound represented by formula (i) (wherein a1 represents a nitrogen atom or a group represented by formula cr6; a2 and a3 are the same as or different from each other and independently represent a nitrogen atom or a group represented by formula ch; r1 represents an aryl group which may be substituted by 1 to 5 substituents independently selected from a substituent group (2) or the like; r2 and r3 are the same as or different from each other and independently represent a hydrogen atom, a halogen atom, a c1-6 alkyl group, a c1-6 haloalkyl group or a c1-6 alkoxy group; and r4 and r5 are the same as or different from each other and independently represent a hydrogen atom, a c1-6 haloalkyl group, a c1-6 alkyl group or the like) or a salt thereof is useful as an anti-fungal agent..

06/05/14
20140154193 

Formulation and the treatment of fungal nail infections


The present invention relates to a formulation and method for the treatment of fungal nail infections, such as those caused by trichophyton rubrum and/or aspergillus niger. The formulation of the invention comprises glucose oxidase, d-glucose and hydrogen peroxide in an aqueous solution.

05/08/14
20140127757 

Heterologous alpha amylase expression in aspergillus


The present invention relates to the co-expression and production of a heterologous alpha amylase and an endogenous glucoamylase in an aspergillus strain and enzyme compositions including the same.. .

04/03/14
20140093939 

Tannase, gene encoding same, and process for producing same


Disclosed is a thermostable tannase derived from a microorganism. Specifically disclosed is a thermostable tannase derived from aspergillus awamori or aspergillus niger.

03/20/14
20140080173 

Production of an aspergillus contamination imprint based on detection of mvoc


(b) detecting microbial volatile organic compounds (mvocs) in the sample. The step (b) comprises searching for a chemical imprint comprising at least one target molecule that is an mvoc associated with an aspergillus metabolism.

02/13/14
20140045238 

Method for producing terpenes


The present invention relates to a method for producing terpenes in fungi, wherein a terpene biosynthetic gene cluster having terpene biosynthetic genes and regulatory regions operably linked to said genes is activated. The invention relates also to a terpene biosynthetic gene cluster and regulatory regions of such terpene biosynthetic gene cluster usable is production of terpenes, use of regulator for regulating the terpene production and use of aspergillus nidulans fgsc a4 for producing terpenes.

01/23/14
20140024098 

Expression of catalase in trichoderma


The invention provides methods for expression of a catalase enzyme in a trichoderma host cell. In one embodiment, the catr gene from aspergillus niger is expressed in trichoderma reesei, resulting in improved yields of catalase enzyme in comparison with expression of catr in a.

12/26/13
20130345177 

Oleyl phosphocholine for the treatment of mycosis


The present invention relates to the use of oleyl phosphocholine (c18:1-pc), or olpc,for the treatment of mycosis, and especially for the treatment of mycosis such as mycosis caused by pathogens belonging to a genus selected from the group consisting of candida, aspergillus, fusarium, cryptococcus, microsporum, sporothrix, trichophyton and scedosporium, for example, candida albicans, candida parapsilosis, candida glabrata, candida krusei, aspergillus fumigatus, aspergillus niger, aspergillus terreus, fusarium solani, scedosporium prolifacans, cryptococcus neoformans, microsporum canis, sporothrix schenkii, trichophyton rubrum, trichophyton mentagrophytes, aspergillus fumigatus, fusarium oxysporum.. .

12/05/13
20130323798 

Method of using alpha-amylase from aspergillus clavatus for saccharification


A fungal α-amylase is provided from aspergillus clavatus (acamyl). Acamyl has an optimal ph of 4.5 and is operable at 30-75° c., allowing the enzyme to be used in combination with a glucoamylase in a saccharification reaction.

11/28/13
20130316065 

Method for the production of duplication and translocation of any region in the chromosome of aspergillus


The present invention relates to a transformant of the fungus belonging to aspergillus wherein a transformation marker gene with deficiency of a terminal part at the 5′ or 3′ end of its coding region is integrated into an outside of a target region in a chromosome of the fungus subject to duplicated translocation, and a transformation marker gene with deficiency of a terminal part at the 3′ or 5′ end of its coding region is integrated into an outside of a region in another chromosome of the fungus to be replaced with the target region.. .

11/28/13
20130315920 

Cross protective epitopes of aspergillus fumigatus and candida albicans


A complex comprising a class ii hla-drb1*03 or class ii hla-drb1*13 molecule bound to a peptide, wherein the peptide comprises the amino acid sequence htytidwtkdavtws or a portion thereof, or a variant of the given amino acid sequence or portion wherein the side chains of one or two or three or four or five or six or seven of the amino acid residues are altered, wherein the peptide comprising the portion, or variant, is capable of binding hla-drb1*03 and/or hla-drb1*13. The complex may be used to select aspergillus and candida antigen-specific t cells.

10/31/13
20130291233 

Methods and compositions for modified ethanol inducible promoter systems


The present invention provides nucleic acid molecules comprising one or more nucleotide sequences selected from the group consisting of the nucleotide sequence of seq id no:1, seq id no:3, seq id no:4, seq id no:5, seq id no:6, seq id no:7, seq id no:8, and/or seq id no:10 that can be operably linked to a promoter, thereby making the promoter inducible by a chemical compound that can induce the expression of the alcohol dehydrogenase system of aspergillus nidulans. Methods for making an inducible promoter and for making the expression of a nucleotide sequence of interest inducible are also provided.

10/24/13
20130280764 

Method of improving the activity of cellulase enzyme mixtures in the saccharification (ligno)cellulosic material


The present invention relates to modified filamentous fungal organisms having improved activity profiles with respect to the conversion of complex carbohydrates into simple sugars from cellulosic materials, including fungal organisms belonging to a genus selected from the group consisting of: chrysosporium, thielavia, talaromyces, thermomyces, thermoascus, neurospora, aureobasidium, filibasidium, piromyces, corynascus, cryplococcus, acremonium, tolypocladium, scytalidium, schizophyllum, sporotrichum, penicillium, gibberella, myceliophthora, mucor, aspergillus, fusarium, humicola, trichoderma, and talaromyces, plus anamorphs and teleomorphs thereof. Filamentous fungal organisms having improved activity profiles are obtained by modifying genes encoding enzymes involved in the production of cellobionolactone, cellobionic acid, gluconolactone, gluconic acid, and related products, by a variety of mutagenic methods, resulting in nucleotide substitutions, insertions, and deletions, increasing the level of saccharification in enzyme mixtures obtained from the modified organisms..

10/24/13
20130280761 

Aspergillus containing beta-glucosidase, beta-glucosidases and nucleic acids encoding the same


A novel microorganism is provided named aspergillus saccharolyticus. Further, beta-glucosidase enzymes encoded by said microorganism are provided, and the use thereof in the degradation of lignocellulosic material.

10/24/13
20130280376 

Enzyme preparation from koji fermentation


The invention provides an enzyme preparation obtainable from a koji fermentation, wherein the koji fermentation comprises mushrooms fermented with aspergillus. The invention further relates to an enzyme preparation obtainable from the fermentation of a mixture of mushrooms and cereal with aspergillus, to a process of producing the enzyme preparation, and to the use of the preparation..

10/10/13
20130266984 

Filamentous fungi with inactivated protease genes for altered protein production


The invention relates to a filamentous fungal cell (e.g., aspergillus sp.) comprising at least one inactivated protease gene chosen from apsb, a homolog of apsb, cpsa, a homolog cpsa, and combinations thereof. Nucleic acids and methods for making the inactivated mutant filamentous fungal cells are provided as well as methods for using the cells for the altered production of endogenous or heterologous proteins of interest..

10/10/13
20130266941 

Diagnostic assays for the detection and identification of aspergilli


Three important species of aspergillus, a. Fumigatus, a.

09/26/13
20130252964 

Compounds and methods for treating candidiasis and aspergillus infections


The present disclosure provides compounds, or pharmaceutically acceptable salts thereof, for killing or inhibiting the growth of a candida or aspergillus species or preventing or treating a mammal having candidiasis (oral and/or disseminated) or an aspergillus infection.. .

09/05/13
20130230848 

Oligonucleotides useful in methods for detecting and characterizing aspergillus fumigatus


Methods for using oligonucleotides in the detection of aspergillus fumigatus are disclosed. The oligonucleotides of the invention have nucleotide sequences derived from the gene encoding the cytochrome p450 14 alpha-sterol demethylase (the cyp51a protein) of aspergillus fumigatus.

08/15/13
20130210099 

Method for the production of erythritol


The invention relates to a method for the production of erythritol, in which erythrose is reduced to erythritol using a nadph-specific enzyme, wherein the enzyme is an erythrose reductase which was isolated from the group of saprophytes selected from the strains of hypocrea, gibberella, aspergillus and penicillium. Hereby it is possible to produce erythritol in high yields..

07/04/13
20130171319 

Method for producing a large region duplication of aspergillus chromosome


Disclosed is a technique which is for duplicating across a wide region any large region on a chromosome of a fungus belonging to aspergillus strain, and which enables the stable and systematic acquisition of a previously un-acquirable fungus belonging to the aspergillus strain having novel traits. Disclosed is a transformant wherein a transformation marker gene sequence is arranged on the outside of terminals (5′, 3′) of a region so as to sandwich an arbitrary region of a chromosome, and chromosome duplication has taken place by means of homologous recombination after double strand breakage generated in a homologous region inside the gene.

06/20/13
20130156884 

Protease enzymes for increased protein digestion rate and absorption and methods of using the same


A food supplement comprises at least one protease enzyme selected from (i) cas #9001-92-7, iub 3.4.23.18 protease from aspergillus; (ii) cas #9001-92-7, iub 3.4.21.7 protease from bacillus; (iii) cas #9001-61-0, iub 3.4.11.1 protease from aspergillus; (iv) cas #9074-07-1, iub 3.4.21.63 protease from aspergillus; (v) cas #9073-78-3, iub 3.4.24.27 protease from aspergillus; (vi) cas #9025-49-4, iub 3.4.23.18 protease from aspergillus; and (vii) combinations thereof. The food supplement may further comprise a protein, a stabilizer, a matrix modifier, a carrier, a preservative, a bulking agent, a dessicant, an emulsifier, an enzyme coating, or combinations thereof.

05/30/13
20130137175 

Methods of inducing leukemia and lymphomas and detecting susceptibility to leukemia/ lymphoma


A diagnostic test is described using aspergillus flavus fungal cultures, ebv or their combination to induce leukemic cell surface markers in mononuclear cells of former or current leukemia patients. Detection of the leukemic transformation by means known in the art, identified patients who have or had leukemia, or potentially may become leukemic.

05/30/13
20130137150 

Enhanced citric acid production in aspergillus with inactivated asparagine-linked glycosylation protein 3 (alg3), and/or increased laea expression


Provided herein are fungi, such as aspergillus niger, having a dolichyl-p-man:man(5)glcnac(2)-pp-dolichyl mannosyltransferase (alg3) gene genetic inactivation, increased expression of a loss of aflr expression a (lae), or both. In some examples, such mutants have several phenotypes, including an increased production of citric acid relative to the parental strain.

05/16/13
20130122144 

Glyceroglycolipid lipase


Disclosed is a glyceroglycolipid lipase which is highly safe, can hydrolyze a neutral fat, a glycerophospholipid or a glyceroglycolipid at about ph 6, is thermally stable to some extent, can hydrolyze lecithin, cannot hydrolyze lysolecithin, can rise a bread when used singly in the production of the bread, and has no unpleasant odor. Specifically disclosed is a glyceroglycolipid lipase derived from a filamentous bacterium aspergillus japonicus..

03/28/13
20130075276 

Glucose sensor


Provided is a glucose sensor that is capable of measuring a glucose concentration even in the case where aspergillus oryzae type fad-gdh (flavin adenine dinucleotide-glucose dehyrogenase) and a ruthenium compound are used in combination. The glucose sensor includes an insulative substrate, an electrode system having a working electrode and a counter electrode provided on the substrate, and a reagent layer provided on the electrode system, wherein the reagent layer contains aspergillus oryzae type fad-gdh, a ruthenium compound, and pms (phenazine methosulfate)..

01/17/13
20130017561 

Lateral flow device for diagnosing microbial infections


Fungal infections are difficult to diagnose. The most common filamentous fungal infection, aspergillosis, carries with it a high mortality.



Aspergillus topics: Aspergillus, Nucleotide, Nucleic Acid, Nucleic Acids, Lovastatin, Aflatoxins, Alcohol Dehydrogenase, Dehydrogenase, Chemical Compound, Citric Acid, Polynucleotide, Polypeptide, Carbohydrates, Complex Carbohydrate, Metabolite

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