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Artemisinin patents

      

This page is updated frequently with new Artemisinin-related patent applications.




 A molecular marker of plasmodium falciparum artemisinin resistance patent thumbnailA molecular marker of plasmodium falciparum artemisinin resistance
K13-propeller polymorphism is a useful molecular marker for tracking the emergence and spread of art-resistant p. Falciparum.
Centre National De La Recherche Scientifique


 Alternative act with natural botanical active gras ingredients for treatment and prevention of the zika virus patent thumbnailAlternative act with natural botanical active gras ingredients for treatment and prevention of the zika virus
An all-natural active ingredient herbal compositions and methods of preparing the same are provided. The novel artemisinin combination therapy (act) consists of artemisinin, derivatives of artemisinin, berberine, capsaicin and tinospora cordifolia.
U.s. Phytotherapy, Inc.


 Treatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents patent thumbnailTreatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents
Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and second agents are detailed herein. The artemisinins include artesunate, dihydroartemisinin, artemether, arteether, artelinate, and art-838.

 Method and  the synthesis of dihydroartemisinin and artemisinin derivatives patent thumbnailMethod and the synthesis of dihydroartemisinin and artemisinin derivatives
The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (dhaa) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous process requires a special kind of reactor and a special combination of reagents comprising a hydride reducing agent, at least one activator such as an inorganic activator, at least one solid base, at least one aprotic solvent and at least one c1-c5 alcohol..
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.


 Innovative methods of treatmenting tuberculosis patent thumbnailInnovative methods of treatmenting tuberculosis
A safe and effective treatment methods to cure and curtail tuberculosis affliction described using high dose vitamin c, and other known anti-mycobacterium tuberculosis drugs especially rifampicin administered intravenously for 6 weeks instead of 6 to 24 months of conventional treatment. Insulin is administered to induce moderate hypoglycemia to augment and add effectiveness of anti-tuberculosis drugs and vitamin c.

 Additional artemisinin and berberine compositions and methods of making patent thumbnailAdditional artemisinin and berberine compositions and methods of making
An alternative act composition consisting of natural botanical active ingredients, all of which are gras (generally regarded as safe by the fda). The novel artemisinin combination therapy (act) consists of artemisinin and its derivatives, berberine, capsaicin, and papaya extract.
U.s. Phytotherapy, Inc.


 Nitrogen-containing heterocyclic ring substituted dihydroartemisinin derivatives and use thereof patent thumbnailNitrogen-containing heterocyclic ring substituted dihydroartemisinin derivatives and use thereof
The present invention belongs to the field of medicinal technique, specifically relates to nitrogen-containing heterocyclic ring-substituted dihydroartemisinin derivatives and their optical isomers according to formula i or ii; wherein substituent x, y, r, r1, r2, r3 and r4 are as defined in the description. The derivatives and compositions thereof can be prepared into clinically acceptable tablets, capsules, injections, ointments, etc., and thus have pharmaceutical uses in the treatment and/or prevention of cancers..
Shenyang Pharmaceutical University


 Two-carbon linked artemisinin-derived trioxane dimers patent thumbnailTwo-carbon linked artemisinin-derived trioxane dimers
Two-carbon linked artemisinin-derived trioxane dimers and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.. .
The Johns Hopkins University


 Artemisinin compounds and synthesis and use thereof patent thumbnailArtemisinin compounds and synthesis and use thereof
The present disclosure describes artemisinin compounds. The compounds can be synthesized using an ugi synthesis reaction and can be used in the treatment of cancers, parasitic infections and yeast infections..
University Of Washington Through Its Center For Commercialization


 Artemisinin and its derivatives for use in the treatment of kidney disease patent thumbnailArtemisinin and its derivatives for use in the treatment of kidney disease
The present invention relates compounds according to formula (i) wherein r1 and r2 are independently h or an optionally substituted group selected from an alkyl, a heteroalkyl, an aryl, a heteroaryl, an arylalkyl, and a heteroarylalkyl, and r3 and r4 taken together form a carbonyl (═o); or wherein r1 and r2 are independently h or an optionally substituted group selected from an alkyl, a heteroalkyl, an aryl, a heteroaryl, an arylalkyl, and a heteroarylalkyl, r3 is h and r4 is h or —or5, wherein r5 is h or an optionally substituted group selected from an alkyl, a heteroalkyl, an aryl, a heteroaryl, an arylalkyl, and a heteroarylalkyl; or pharmaceutically acceptable salts or esters thereof, for use in the treatment of kidney disease, in particular in the treatment of acute kidney injury. The present invention also relates to methods of treatment of the same and methods of kidney transplant surgery and coronary artery bypass graft surgery using the compounds of formula (i)..
Queen Mary & Westfield College, University Of London


Method and device for the synthesis of artemisinin

From dihydroartemisinic acid in a continuous flow reactor using singlet oxygen as well as to the continuous flow reactor for producing artemisinin.. .

Artemisinin derivatives, methods for their preparation and their use as antimalarial agents

Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions c7 and c6a, and optionally, in conjunction with modifications at positions c10 and c9, via chemoenzymatic methods.
University Of Rochester

Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions

The present invention relates to the treatment of trauma haemorrhage or trauma haemorrhage-induced organ injury and associated disorders (in particular stoke, burns and brain injury) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the treatment of myocardial infarction and coronary heart disease (and associated disorders) using the anti-malarial compound artemisinin and its derivatives.
Queen Mary & Westfield College, University Of London

Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections

In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication of a virus, by administering artemisinin-related compounds..
Georgetown University

Monomeric trioxane amide sulfur compounds

Anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in plasmodium berghei-infected mice. Selected anilides derivatives administered orally as one single-digit dose combined with mefloquine hydrochloride were completely curative, i.e., all 5 of the mice in the particular treatment group had no detectable parasitemia on day 30 post infection, gained as much weight by day 30 post infection as the control mice (no infection), and behaved normally..
The Johns Hopkins University

Artemisinin with berberine compositions and methods of making

An all-natural herbal composition and methods of preparing the same are provided. The novel artemisinin combination therapy (act) consists of artemisinin and its derivatives and berberine, the two active substances mixed with various selected excipient compounds to form a single pill, tablet or capsule for treatment and prevention of malaria, dengue fever, yellow fever, dysentery, lyme disease, babesiosis, progressive multifocal leukoencephalopathy, helicobacter pylori, and colitis, in adults and children.
U.s. Phytotherapy, Inc.

Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias

In one aspect, the invention relates to compositions comprising bcr-abl tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with bcr-abl dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..

Methods and compositions for treating viral infections

The present invention provides compositions and methods for treating, preventing, and inhibiting viral replication, viral infections and viral diseases and disorders, comprising the use of artemisinin derivatives having anti-viral activity.. .
Hadasit Medical Research Services And Development

Method and device for the synthesis of artemisinin

From dihydroartemisinic acid in a continuous flow reactor using singlet oxygen as well as to the continuous flow reactor for producing artemisinin.. .

Combination therapy and uses thereof for treatment and prevention of parasitic infection and disease

The invention relates to compounds, methods, uses, compositions, combinations, kits and packages for the prevention and/or treatment of parasite infection (e.g., plasmodium parasites) and/or disease (e.g., malaria) based on uses of (a) cystamine, cysteamine, and analogs, derivatives, prodrugs, precursors thereof; an agent capable of inducing their production; and/or salts thereof, and (b) artemisinin and functional derivative, analog, conjugate, metabolite, prodrug or precursor thereof, and/or salts thereof.. .

Suppression and prevention of tumors and treatment of viruses

Combinations of betaine and vitamin c are used to suppress or prevent malignant tumors or to treat viruses, e.g., by combining the two ingredients in a product consumed by a human, dog, or cat, such as an aqueous liquid such as grape juice, the ingredients being provided in containers with instructions for use, or in finished products, especially with support of tests demonstrating the effectiveness of the treatment for, e.g., preventing tumors in populations known to be at risk of developing tumors, or, treating existing cancers in combination with other cancer drugs such as anastrozole and/or fulvestrant and/or artemisinin either concurrently or sequentially to prevent the cancer from growing when the cancer drug is not being used, or in the treatment of viruses.. .

Artemisinin-based combination therapy for treating viral mediated disease

The present invention describes a method of treating individuals suffering from microbial infections, including a viral infection such as dengue fever, using an improved artemisinin combination therapy (act), known as tri-act. The improved act therapy includes administering a combination of three drugs.

Enhanced artemisinin-based combination therapy for treating parasitic mediated disease

The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved artemisinin combination therapy (act), known as actrx tri-act plus. The improved act therapy includes administering a combination of four drugs.

Artemisinins in the clinical and veterinary management of kinetoplastid infextions

The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections.

Total synthesis of artemisinin

The present invention provides a method for manufacturing artemisinin and its congeners from cyclohexenone as a starting material.. .

Artemisinin-based combination therapy for treating parasitic mediated disease

The present invention describes a method of treating individuals suffering from microbial infections, including a parasitic disease such as malaria, by using an improved artemisinin combination therapy, known as tri-act. The improved act therapy includes administering a combination of three drugs.

Artemisinin-based combination therapy for treating viral mediated disease

The present invention describes a method of treating individuals suffering from microbial infections, including a viral infection such as dengue fever, using an improved artemisinin combination therapy (act), known as tri-act. The improved act therapy includes administering a combination of three drugs.



Artemisinin topics:
  • Artemisinin
  • Dengue Fever
  • Lenalidomide
  • Cytomegalovirus
  • Loperamide
  • Therapeutical
  • Antioxidant
  • Immunomodulator
  • Parasitic Diseases
  • Parasitic Disease
  • Fibroblast
  • Replication
  • Progressive Multifocal Leukoencephalopathy
  • Combination Therapy
  • Yellow Fever


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    This listing is a sample listing of patent applications related to Artemisinin for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Artemisinin with additional patents listed. Browse our RSS directory or Search for other possible listings.


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