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Artemisinin

Artemisinin-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections
Georgetown University
August 31, 2017 - N°20170246145

In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication ...
Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
University Of Rochester
August 10, 2017 - N°20170226122

Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions c7 and c6a, and optionally, in conjunction with modifications at positions c10 and c9, via chemoenzymatic ...
Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions
Queen Mary University Of London
June 29, 2017 - N°20170182000

The present invention relates to the treatment of trauma haemorrhage or trauma haemorrhage-induced organ injury and associated disorders (in particular stoke, burns and brain injury) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the treatment of myocardial infarction and coronary heart disease (and associated disorders) using the anti-malarial compound artemisinin and its derivatives. The ...
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Treatment or prevention of seborrheic keratosis using artemisinin and derivatives thereof
Epipharm Ag
February 09, 2017 - N°20170035727

The invention relates to a method of treating or preventing seborrheic keratosis. The method comprises locally applying to a subject in need thereof artemisinin and/or one or more structurally related compounds. Also disclosed are topical formulations comprising artemisinin and/or one or more structurally related compounds.
Medical use of artemisinin compounds and gephyrin agonists
Cemm - Forschungszentrum Für Molekulare Medizin Gmbh
February 02, 2017 - N°20170027929

The invention refers to btbd9 binders and gephyrin binders for medical use and in particular an artemisinin compound of general formula i for use in the treatment of a diabetes patient, as well as a method of identifying suitable lead candidates.
Combination artemisinin and chemiluminescent photodynamic therapy and uses therefor
Washington University
December 22, 2016 - N°20160367674

Photodynamic therapy-based methods of treating diseases such as cancer and malaria are disclosed. These methods include administering 5-aminolevulinic acid (ala), luminol and artemisinin (art). Art and ala administered in combination with luminol can kill malaria parasites without host toxicity. In some aspects, the methods further include administration of a luminol enhancer such as 4-iodophenol. The disclosed methods can also be ...
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Alternative act with natural botanical active gras ingredients for treatment and prevention of the zika ...
U.s. Phytotherapy, Inc.
September 01, 2016 - N°20160250181

An all-natural active ingredient herbal compositions and methods of preparing the same are provided. The novel artemisinin combination therapy (act) consists of artemisinin, derivatives of artemisinin, berberine, capsaicin and tinospora cordifolia. When formulated in a gel cap, the composition can consist of only artemisinin, berberine, capsaicin, and tinospora cordifolia. A blended mixture and inert ingredients, such as selected excipient compounds, ...
Treatment of leukemia with artemisinin derivatives and combinations with other antineoplastic agents
U.s. Phytotherapy, Inc.
June 23, 2016 - N°20160175331

Methods of treating cancer, such as leukemia, via administration of therapeutically effective amounts of artemisinins and second agents are detailed herein. The artemisinins include artesunate, dihydroartemisinin, artemether, arteether, artelinate, and art-838. The second agents include bcl-2 inhibitors such as abt-199, abt-263, and abt-737; kinase inhibitors such as lestaurtinib, midostaurin, and sorafenib; and anti-neoplastic agents such as cytarabine, doxorubicin, etoposide, cyclophosphamide, ...
Method and apparatus for the synthesis of dihydroartemisinin and artemisinin derivatives
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.
May 26, 2016 - N°20160145265

The present invention is directed to a method for continuous production of dihydroartemisinin and also artemisinin derivatives derived from dihydroartemisinin by using artemisinin or dihydroartemisinic acid (dhaa) as starting material as well as to a continuous flow reactor for producing dihydroartemisinin as well as the artemisinin derivatives. It was found that the reduction of artemisinin to dihydroartemisinin in a continuous ...
Innovative methods of treatmenting tuberculosis
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.
March 17, 2016 - N°20160074480

A safe and effective treatment methods to cure and curtail tuberculosis affliction described using high dose vitamin c, and other known anti-mycobacterium tuberculosis drugs especially rifampicin administered intravenously for 6 weeks instead of 6 to 24 months of conventional treatment. Insulin is administered to induce moderate hypoglycemia to augment and add effectiveness of anti-tuberculosis drugs and vitamin c. Invention also delivers the drugs ...
Additional artemisinin and berberine compositions and methods of making
U.s. Phytotherapy, Inc.
March 03, 2016 - N°20160058809

An alternative act composition consisting of natural botanical active ingredients, all of which are gras (generally regarded as safe by the fda). The novel artemisinin combination therapy (act) consists of artemisinin and its derivatives, berberine, capsaicin, and papaya extract. The four active substances mixed with various selected excipient compounds to form a single pill, tablet or capsule for the treatment ...
Nitrogen-containing heterocyclic ring substituted dihydroartemisinin derivatives and use thereof
Shenyang Pharmaceutical University
January 14, 2016 - N°20160009729

The present invention belongs to the field of medicinal technique, specifically relates to nitrogen-containing heterocyclic ring-substituted dihydroartemisinin derivatives and their optical isomers according to formula i or ii; wherein substituent x, y, r, r1, r2, r3 and r4 are as defined in the description. The derivatives and compositions thereof can be prepared into clinically acceptable tablets, capsules, injections, ointments, etc., ...
Two-carbon linked artemisinin-derived trioxane dimers
The Johns Hopkins University
December 17, 2015 - N°20150361088

Two-carbon linked artemisinin-derived trioxane dimers and methods of their use for treating subjects infected with malaria or other parasitic infectious diseases including, but not limited to, toxoplasmic infection; subjects afflicted with psychiatric conditions associated with toxoplasmic infection; and subjects afflicted with cancer.
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Artemisinin and its derivatives for use in the treatment of kidney disease
Queen Mary & Westfield College, University Of London
November 26, 2015 - N°20150335612

The present invention relates compounds according to formula (i) wherein r1 and r2 are independently h or an optionally substituted group selected from an alkyl, a heteroalkyl, an aryl, a heteroaryl, an arylalkyl, and a heteroarylalkyl, and r3 and r4 taken together form a carbonyl (═o); or wherein r1 and r2 are independently h or an optionally substituted group ...
Method and device for the synthesis of artemisinin
Queen Mary & Westfield College, University Of London
November 19, 2015 - N°20150328617

From dihydroartemisinic acid in a continuous flow reactor using singlet oxygen as well as to the continuous flow reactor for producing artemisinin.
Artemisinin derivatives, methods for their preparation and their use as antimalarial agents
University Of Rochester
October 22, 2015 - N°20150299217

Derivatives of the antimalarial agent artemisinin, compositions comprising the derivatives, methods for preparing the derivatives, and their uses in pharmaceutical compositions intended for the treatment of parasitic infections are provided. Methods are provided for the production of artemisinin derivatives via functionalization of positions c7 and c6a, and optionally, in conjunction with modifications at positions c10 and c9, via chemoenzymatic ...
Artemisinin and its derivatives for use in the treatment of trauma haemorrhage and associated conditions
Queen Mary & Westfield College, University Of London
October 22, 2015 - N°20150297558

The present invention relates to the treatment of trauma haemorrhage or trauma haemorrhage-induced organ injury and associated disorders (in particular stoke, burns and brain injury) using the anti-malarial compound artemisinin and its derivatives. The present invention also relates to the treatment of myocardial infarction and coronary heart disease (and associated disorders) using the anti-malarial compound artemisinin and its derivatives. The ...
Use of artemisinin for treating tumors induced by oncogenic viruses and for treating viral infections
Georgetown University
July 16, 2015 - N°20150196530

In certain aspects, the invention relates to methods of treating proliferative cervical disorders (such as cervical cancer and cervical dysplasia) and treating virus infection by administering artemisinin-related compounds. In certain aspects, the invention relates to methods of treating a tumor induced by an oncogenic virus, methods of killing or inhibiting a squamous cell carcinoma, and methods of inhibiting the replication ...
Monomeric trioxane amide sulfur compounds
The Johns Hopkins University
July 02, 2015 - N°20150183798

Anilide derivatives of the natural trioxane artemisinin were prepared and evaluated for antimalarial efficacy in plasmodium berghei-infected mice. Selected anilides derivatives administered orally as one single-digit dose combined with mefloquine hydrochloride were completely curative, i. E., all 5 of the mice in the particular treatment group had no detectable parasitemia on day 30 post infection, gained as much weight by day 30 post ...
Artemisinin with berberine compositions and methods of making
U.s. Phytotherapy, Inc.
May 28, 2015 - N°20150148364

An all-natural herbal composition and methods of preparing the same are provided. The novel artemisinin combination therapy (act) consists of artemisinin and its derivatives and berberine, the two active substances mixed with various selected excipient compounds to form a single pill, tablet or capsule for treatment and prevention of malaria, dengue fever, yellow fever, dysentery, lyme disease, babesiosis, progressive multifocal ...
Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias
U.s. Phytotherapy, Inc.
May 14, 2015 - N°20150133462

In one aspect, the invention relates to compositions comprising bcr-abl tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with bcr-abl dysfunction using the compounds and compositions. This abstract is intended as a ...
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