An immunoassay method is described which detects o-desmethyltramadol only. This enables an assay of high sensitivity and specificity avoiding false positive results. The unique antibodies incorporated in the immunoassay method can be combined with antibodies which detect mitragynine to provide an assay which increases the possibility of detecting the commonly found drug combination of o-desmethyltramadol and mitragynine.

Disclosed is an antibody or a binding fragment thereof which binds to quetiapine, which can be used to detect quetiapine in a sample such as in a competitive immunoassay method. The antibody or the fragment thereof can be used in a lateral flow assay device for point-of-care detection of quetiapine, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in ...

Disclosed is an antibody or a binding fragment thereof that binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody or fragment thereof can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a ...

Hemoglobin, its variants, and glycated forms of each are determined individually in a multiplex assay that permits correction of the measured level of hba1c to account for glycated variants and other factors related to the inclusion of the variants in the sample. New antibodies that are particularly well adapted to the multiplex assay are also provided.

Provided are compositions that contain mammalian cells for use in detecting antibodies. The mammalian cells are modified such that they do not contain ledgf protein. The mammalian cells are immobilized on a solid substrate. The compositions can also contain mammalian cells that contain the ledgf protein. Methods for using the cell compositions in diagnostic approaches are included, as are kits ...

The present invention relates to a method for diagnosis of a cancer, comprising the steps of (i) determining the level of antibodies against vascular endothelial growth factor receptor (vegfr) in a sample from a subject to be diagnosed, (ii) comparing the determined level in the sample to a control level derived from subjects without cancer; wherein a decreased level in ...

The present invention provides assays for detecting and measuring the presence or level of neutralizing and non-neutralizing autoantibodies to biologics such as anti-tnfα drug therapeutics in a sample. The present invention is useful for monitoring the formation of neutralizing and/or non-neutralizing anti-drug antibodies over time while a subject is on biologic therapy. The present invention is also ...

A chemiluminescent detection system, as well as kits and microfluidics devices containing same, are disclosed. Methods of using the system, kits, and devices are also disclosed. The first, second, and third antibodies or binding fragments thereof may be provided in any form that allows these antibodies/binding fragments to function in accordance with the presently disclosed and claimed inventive concept(...

The present disclosure relates to compositions and methods based on a fast, efficient chemical reaction for conjugating a pore-forming protein, such as α-hemolysin, to a biomolecule, such as antibodies, receptors, and enzymes, such as dna polymerase, and the use of such pore-forming protein conjugates in nanopore devices and methods.

Compositions having pesticidal activity and methods for their use are provided. Compositions include isolated and recombinant polypeptides having pesticidal activity, recombinant and synthetic nucleic acid molecules encoding the polypeptides, dna constructs and vectors comprising the nucleic acid molecules, host cells comprising the vectors, and antibodies to the polypeptides. Polynucleotide sequences encoding the polypeptides can be used in dna constructs or ...

Bruton's tyrosine kinase (btk) plays an important role in the pathophysiology of local inflammation in acute lung injury (ali)/acute respiratory distress syndrome (ards). A unique two hit model of ali induced by lipopolysaccharide (lps)/immune complex (ic)—was developed, along with viral-induced ali caused by influenza virus and copd caused by second hand smoke. Two types or therapeutics (...

The present invention is directed towards an artificial rna nanostructure comprising multiple external strands of rna, each external strand comprising about 40-50 nucleotides; one internal strand of rna comprising more than about 50 nucleotides; the internal strands and external strands assembled to form a triangle nanostructure, a square nanostructure, or a polygon nanostructure and a prna three-way junction (3wj) motif at ...

Methods of generating same and uses thereof are also provided.

The present invention provides antibodies that bind to tie2 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human tie2 and block the interaction between tie2 and one or more tie2 ligands such as angiopoietin 1 (ang1), angiopoietin 2 (ang2), angiopoietin 3 (ang3) and/or angiopoietin 4 (ang4). The antibodies of the ...

The present invention relates to antibodies binding to human her3 (anti-her3 antibody), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

The invention provides anti-her2 antibodies and immunoconjugates and methods of using the same.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of acute lymphoblastic leukemia. The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of a bispecific antibody that specifically binds to cd20 and cd3.

The present invention relates to combination therapies with anti-cd38 antibodies.

The present invention provides methods for treating, reducing the severity, or inhibiting the growth of cancer (e. G., a b-cell cancer such as hodgkin's lymphoma or acute lymphoblastic leukemia). The methods of the present invention comprise administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment thereof that specifically binds to programmed death 1 (...

A ph-dependent antibody that binds an antigen with high affinity at a first ph and rapidly dissociates at a second ph, wherein the antigen is a transferrin receptor (tfr), wherein the association at the second ph/the first ph is less than 20%, and wherein the ph-dependent antibody comprises at least two consecutive histidine residues at a single complementarity determining region (...

Alzheimer's and parkinson's disease comorbidity, and pure autonomic failure, as well as multiple system atrophy (msa).