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Antibodies patents



      
           
This page is updated frequently with new Antibodies-related patent applications. Subscribe to the Antibodies RSS feed to automatically get the update: related Antibodies RSS feeds. RSS updates for this page: Antibodies RSS RSS


Method for enhanced photoepilation based on metallic nano-complexes

Method for enhanced photoepilation based on metallic nano-complexes

Antibodies to tip-1 and grp78

Antibodies to tip-1 and grp78

Date/App# patent app List of recent Antibodies-related patents
10/23/14
20140317765
 Transgenic birds that produce chimeric human immunoglobulins patent thumbnailTransgenic birds that produce chimeric human immunoglobulins
The invention relates to transgenic birds capable of producing chimeric immunoglobulins, with a combination of human and avian sequence, in their b cells. In some embodiments, the birds are chickens.
10/23/14
20140316394
 Method for enhanced photoepilation based on metallic nano-complexes patent thumbnailMethod for enhanced photoepilation based on metallic nano-complexes
The present invention relates to a composition for topical application on skin for photoepilation comprising nanocomplexes which comprise a nanoparticle supporting an lsp resonance which is coated with at least a chemical compound, wherein said chemical compound is selected from the group consisting of polyionic polymers, heterobifunctional compound of the surface assembled monolayer type, antibodies and their mixtures. The present invention also relates to a photoepilation method which comprises the steps of (i) applying to the skin surface the composition for topical application of the present invention, and (ii) applying a radiation to said surface of the skin..
10/23/14
20140316186
 Antibodies to tip-1 and grp78 patent thumbnailAntibodies to tip-1 and grp78
The present invention is directed towards isolated antibodies that bind to grp78 and tip-1.. .
10/23/14
20140316115
 Method of antibody purification patent thumbnailMethod of antibody purification
The present invention relates to a method for preparing a population of antibodies to have high purity and high quality by removing antibody isoforms and impurities through the use of a cation exchange column, a hydrophobic interaction column, and an anion exchange column successively, without using a protein a column; and to a population of antibodies prepared by the above method.. .
10/23/14
20140316113
 Method for the humanization of antibodies and humanized antibodies thereby obtained patent thumbnailMethod for the humanization of antibodies and humanized antibodies thereby obtained
Method for the humanization of the vh and vl variable regions of an animal antibody of known sequence, humanized animal antibody obtainable according to the method, in particular anti-ngf and anti-trka humanized animal antibodies.. .
10/23/14
20140315761
 Kits for determining male fertility by measuring levels of a2v-atpase, g-csf, mip 1 alpha, mcp-1, and methods and kits for improving reproductive outcomes in artificial insemination procedures patent thumbnailKits for determining male fertility by measuring levels of a2v-atpase, g-csf, mip 1 alpha, mcp-1, and methods and kits for improving reproductive outcomes in artificial insemination procedures
The present invention provides a kit for determining male fertility including a container system containing a plurality of enzyme-linked antibodies one of each capable of binding to analytes atp6v0a2, g-csf, mip 1α, and mcp-1. The kit further includes suitable packaging and a set of instructions for using the enzyme-linked antibodies with a seminal sample to determine the fertility of the sample..
10/23/14
20140315760
 Photonic blood typing patent thumbnailPhotonic blood typing
Photonic devices, systems, and methods for detecting an analyte in a biological solution (e.g., whole blood) are provided. Representative photonic devices are optical ring resonators having nanoscale features and micron-sized diameters.
10/23/14
20140315749
 Methods and kits for detecting ige-expressing b cells patent thumbnailMethods and kits for detecting ige-expressing b cells
The invention relates to the field of medical diagnostics. In particular, it relates method and kits for identification and classification of ige-related diseases, e.g.
10/23/14
20140315251
 Interleukin-31 monoclonal antibody patent thumbnailInterleukin-31 monoclonal antibody
An isolated antibody that specifically binds to at least one of canine interleukin-31 (il-31) or feline il-31 is provided. Such antibodies can be in the form of diagnostic and/or veterinary compositions useful for treating a pruritic and/or allergic condition in dogs or cats..
10/23/14
20140315250
 Humanized antibodies against tl1a patent thumbnailHumanized antibodies against tl1a
Disclosed are humanized antibodies that bind specifically to tnf superfamily member 15 (tnfsf15), also known as tl1a. Methods of making and using the anti-tl1a antibodies are also described.
10/23/14
20140315225
Methods and compositions for detecting the presence of one or more autoantibodies
This disclosure describes methods and compositions for immunohistochemically detecting the presence of a srp autoantibody in a biological sample.. .
10/23/14
20140315224
Detection device, detection strip, and detection system
A detection device applied for detecting body fluids includes a substrate and a plurality of anti-growth factor antibodies. The substrate includes at least one reaction portion.
10/23/14
20140315223
Method of simultaneous detection of heparin-induced immunoglobulins types g, a, and m
The invention provides a method for detecting heparin-induced antibodies comprising a) binding a pf4-heparin antigen to a solid surface; b) incubating the bound pf4-heparin with a sample comprising heparin-induced antibodies to be detected; c) contacting the sample with at least two labeled secondary antibodies, wherein the secondary antibodies bind to heparin-induced antibodies present in the sample; d) detecting the presence of the labeled secondary antibodies using flow cytometry or a suitable method, wherein the heparin-induced antibodies bound to the secondary antibodies are identified. In one embodiment, the at least two secondary antibodies are anti-human antibodies which specifically bind to heparin-induced antibodies and are selected from the group consisting of ig, igg, iga, and igm..
10/23/14
20140315222
Method for measuring sialic acid in immunoglobulin g and immunoglobulin g anti-double-stranded dna antibodies
A method for measuring the amount of sialic acid in immunoglobulin g and immunoglobulin g anti-ds dna antibodies is disclosed. The method for measuring the amount of sialic acid in immunoglobulin g in the present invention uses culture fluid, blood, plasma, or serum to directly measure the amount of sialic acid in immunoglobulin g.
10/23/14
20140315212
Alpha toxin detection of gpi anchored proteins
The present invention relates to a method for the purification, concentration and identification of glycosylphosphatidylinositol anchored proteins (gpi-aps) from a biological sample (cells, tissues and/or blood/serum) in a patient or subject, including a human patient or subject. A new method to separate gpi-anchored glycoproteins, a class of glycoproteins found in all animal cells and fluids including serum, from other glycoproteins and proteins for the purpose of identifying potential biomarkers for various diseases, including cancer, especially breast cancer, vaginal cancer, endometrial cancer, uterine cancer, cervical cancer, pancreatic cancer and prostate cancer.
10/23/14
20140314858
Ipnv-isav bivalent vaccine using a virus-like particle-based platform and methods of using the same
The present invention provides bivalent oral vaccines against infectious pancreatic necrosis virus (ipnv) and infectious salmon anemia virus (isav). Yeast cells comprise an expression vector comprising (i) a polynucleotide sequence encoding a vp2 capsid protein of ipnv and (ii) a polynucleotide sequence encoding one or more antigenic epitopes of hemaglutinin of isav.
10/23/14
20140314806
Potency test for vaccine formulations
The invention relates to certain methods for the determination of an antigen content of a first antigen in a mixture comprising two or more antigens. The invention also relates to a potency test for an antigen in a combination vaccine.
10/23/14
20140314784
Anti-cxcr4 antibodies and methods of use
The disclosure relates to antibodies or antigen binding fragments that specifically bind to cxcr4 and inhibit the biological activity of cxcr4 and uses of such agents. More specifically the disclosure relates to fully human antibodies or antigen binding fragments directed to cxcr4 that specifically bind to cxcr4 and uses of these antibodies.
10/23/14
20140314782
Anti-notch2 nrr antibodies
The invention provides anti-notch antibodies, and in particular, antibodies that bind notch2 nrr, and methods of using the same.. .
10/23/14
20140314781
Formulation of human antibodies for treating tnf-alpha associated disorders
A liquid aqueous pharmaceutical formulation is described which has a high protein concentration, a ph of between about 4 and about 8, and enhanced stability.. .
10/23/14
20140314780
Compositions using antibodies directed to gpnmb and uses thereof
The present invention relates to antibodies, including fully human monoclonal antibodies, with specificity to gpnmb, and uses of such antibodies. The present invention further provides compositions that increase expression of gpnmb on the surface of tumor cells, and methods of using such compositions to increase the anti-cancer activity or other therapeutic efficacy of the antibodies and immunoconjugates provided herein..
10/23/14
20140314777
Monoclonal antibodies targeting neutralizing epitopes on h5 influenza virus of clade 2.3
The present invention relates to murine monoclonal antibodies c, f and h which target major neutralizing epitopes of influenza h5 hemagglutinin of clade 2.3 and active fragments thereof. The present invention also relates to methods and compositions for the prophylaxis and treatment of h5n1 influenza using murine monoclonal antibodies c, f or h or active fragments thereof.
10/23/14
20140314776
Method of treating alveolar bone loss through the use of anti-sclerostin antibodies
The invention provides a method of treating alveolar bone loss involving administration of a sclerostin inhibitor to a subject in need thereof.. .
10/23/14
20140314774
Her3 antibodies and uses thereof
Provided herein are antibodies specific for her3. Also provided are methods of treating cancer in a subject comprising administering an effective amount of the antibodies described herein to the subject..
10/23/14
20140314773
Compositions and methods for treating alzheimer's disease
The present disclosure provides for a hyperimmune preparation comprising human polyclonal antibodies or fragments thereof specific to a cyclic peptide having an amino acid sequence comprising snk. The cyclic peptide may comprise an amino acid sequence gsnk (seq id no: 1), snkg(seq id no: 2), gsnkg (seq id n0:3), csnkg (seq id no: 4), cgsnkgc (seq id no: 5), cgsnkgg (seq id no: 6), or ccgsnkgc (seq id no: 7).
10/23/14
20140314772
Anti-c5a binding moieties with high blocking activity
The present invention relates to binding moieties that specifically bind to a conformational epitope of c5a, in particular human c5a. Preferred binding moieties are anti-c5a antibodies that bind to this conformational epitope.
10/23/14
20140314771
Combination therapy of antibodies against human csf-1r and tlr9 agonist
The present invention relates to the combination therapy of antibodies against human csf-1r with a tlr9 agonist.. .
10/23/14
20140314770
Kidney disease targets and uses thereof
The present invention provides a method for diagnosing and detecting diseases associated with kidney. The present invention provides one or more proteins or fragments thereof, peptides or nucleic acid molecules differentially expressed in kidney diseases (kcat) and antibodies binds to kcats.
10/23/14
20140314769
Neutralizing antibodies and methods of use thereof
This invention provides monoclonal antibodies that recognize the toll-like receptor 4/md-2 receptor complex, and monoclonal antibodies that recognize the tlr4/md2 complex as well as tlr4 when not complexed with md-2. The invention further provides methods of using the humanized monoclonal antibodies as therapeutics.
10/23/14
20140314767
Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide
The invention features methods for preventing or treating visceral pain, including pain associated with functional bowel disorder, inflammatory bowel disease and interstitial cystitis, by administering an anti-cgrp antagonist antibody.. .
10/23/14
20140314766
Mig-7 as a specific anticancer target
Aspects of the present invention provide novel mig-7 encoding nucleic acids and mig-7 polypeptides, recombinant dna expression systems and host cells containing same, as well as methods of inhibiting expression of the subject nucleic acid molecules, inhibiting production of the encoded proteins or polypeptides, inhibiting metastasis of a carcinoma cell in a subject (including in humans), inhibiting migration/invasion of and mimicking of normal cells by carcinoma cells in a subject, detecting the presence of a cancer cell (e.g., a migrating/invading cancer cell or carcinoma cell mimic, and tumor neovascularization) in a sample of a subject's tissue or body fluids, and inhibiting the migration/invasion of or endothelial cell mimicking by a placental cell into the blood stream or vessels of a female mammal. Particular aspects relate to novel anti-mig-7 antibodies, diagnostic and/or prognostic methods, and therapeutic methods comprising use of the inventive nucleic acids, polypeptides and antibodies or derivatives thereof..
10/23/14
20140314764
Bi-specific antibodies for medical use
A bispecific antibody format devoid of an active fc moiety comprising a monovalent binding site for a death receptor and at least one binding site for a cell surface antigen expressed on b-cells, for use in the treatment or prevention of b cell mediated autoimmune diseases.. .
10/23/14
20140314763
Cross-reactive and bispecific anti-il-17a/f antibodies
The present invention relates generally to antibodies cross-reactive with il-17a and il-17f, and bispecific anti-il-17a/f and their uses.. .
10/23/14
20140314754
Humanized neuraminidase antibody and methods of use thereof
Antibodies against influenza neuraminidase, compositions containing the antibodies, and methods of using the antibodies are provided herein.. .
10/23/14
20140314744
Mcam antagonists and methods of treatment
Described herein are mcam antagonists, including mcam antagonist antibodies capable of inhibiting the interaction between mcam and it ligand, a laminin α4 chain, e.g., an α4 chain of laminin 411. These mcam antagonists, e.g., anti-mcam antibodies, may be useful to treat neuroinflammatory conditions, for example, multiple sclerosis and parkinson's disease, by inhibiting the infiltration of mcam-expressing cells into the central nervous system (cns), e.g., extravasation of th17 cells into the cns..
10/23/14
20140314742
Endoglin antibodies
The present application relates to compositions of humanized and humanized/deimmunized anti-endoglin antibodies and antigen-binding fragments thereof. One aspect relates to antibodies having one or more modifications in at least one amino acid residue of at least one of the framework regions of the variable heavy chain, the variable light chain or both.
10/23/14
20140314710
Il-12 p40 monomer, monoclonal antibody against p40 homodimer and the combination of the two for autoimmune disease treatment
A novel approach to discover new drugs against ms and other autoimmune diseases is disclosed. The p40 family of cytokines has four members which include interleukin-12 (il-12), the p40 monomer (p40), the p40 homodimer (p402), and the il-23.
10/23/14
20140314667
Methods of treating epidermal growth factor deletion mutant viii related disorders
The present invention relates to methods of treating treating epidermal growth factor deletion mutant viii (egfrviii) related disorders, such as glioblastoma or anaplastic astrocyte tumors, using antigen binding proteins, including antibodies against egfrviii conjugated to a drug. Diagnostic and therapeutic formulations of such antibodies and drug conjugates thereof are also provided..
10/23/14
20140314666
Targeted carriers for drug delivery across the gastrointestinal epithelium
A system and method for transcellular transport of compositions containing agents (e.g., research, analytical, reporter or molecular probes, diagnostic and therapeutic agents, biologically active agents, research agents, analytical agents, imaging agents, monitoring agents, enzymes, proteins, peptides, nucleic acids, lipids, sugars, hormones, lipoproteins, chemicals, viruses, bacteria, cells, including modified cells, biosensors, markers, antibodies and/or ligands) across the gastrointestinal epithelial layer including use of a composition containing the agent and a targeting moiety, specific for a determinant at the target location. An exemplary composition of the system includes an anti-icam antibody targeting moiety, specific for targeting icam-1.
10/23/14
20140312879
Method to realize electronic field-effect transistor sensors
A transistor includes at least one conductive layer, at least one gate dielectric layer and at least one semiconducting film deposited on top of a receptor molecule layer previously deposited or covalently linked to the surface of the gate dielectric. The layer of biological material includes single or double layers of phospholipids, layers made of proteins such as receptors, antibodies, ionic channels and enzymes, single or double layers of phospholipids with inclusion or anchoring of proteins such as: receptors, antibodies, ionic channels and enzymes, layers made of oligonucleotide (dna, rna, pna) probes, layers made of cells or viruses, layers made of synthetic receptors for example molecules or macromolecules similar to biological receptors for properties, reactivity or steric aspects..
10/23/14
20140311909
Protein standard
Disclosed herein is a protein standard for gel electrophoresis. The standard may be detected using multiple modalities.
10/16/14
20140309404
Bmp-6 antibodies
The present invention relates to antibodies, or antigen-binding fragments thereof, that bind to human bmp-6, compositions comprising such antibodies, or antigen-binding fragments thereof, and methods of using the same for treatment of anemia of chronic disease.. .
10/16/14
20140309289
Combination anti-hiv vectors, targeting vectors, and methods of use
Recombinant lentiviral vectors containing at least: a lentiviral backbone comprising essential lentiviral sequences for integration into a target cell genome; a nucleic acid encoding a ccr5 rnai; and an expression control element that regulates expression of the nucleic acid encoding the ccr5 rnai element, are provided by this invention. In an alternative aspect, the vector also contains polynucleotides encoding trim5 alpha and hiv tar decoy sequences along with gene expression regulation elements such as promoters operatively linked to the polynucleotides.
10/16/14
20140309133
Novel method for diagnosis of high-affinity binders and marker sequences
The present invention relates to a novel method for diagnosing high-affinity binders, in particular antibodies or autoantibodies, and the identification, characterisation and selection of marker sequences and diagnostic use thereof, in particular in the form of a panel. The invention also relates to a singleplex assay in which the discovered selection of marker sequences is used in the form of a panel and high-affinity binders are detected using a single signal..
10/16/14
20140308755
Hmgb1 and anti-hmgb1 antibodies for the prognostic of neurological disorders
The invention relates to in vitro method for quantitating the antibodies specific for high mobility group box i (hmgb1) contained in a sample, in particular a serum sample or a cerebrospinal fluid sample obtained from a patient, and the use of this method in the prognostic and/or diagnosis of neurological disorders. These methods are in particular applicable to the monitoring of the human immunodeficiency virus (hiv) infection of a subject who is known to be infected with hiv and in the prognostic and/or diagnostic of the state of progression of acquired immune deficiency syndrome (aids) or the state of progression toward aids, in particular the state of progression or the state of progression toward neurological disorders associated with aids.
10/16/14
20140308703
Mammalian cell lines for increasing longevity and protein yield from a cell culture
Disclosed are compositions and methods for increasing the longevity of a cell culture and permitting the increased production of proteins, preferably recombinant proteins, such as antibodies, peptides, enzymes, growth factors, interleukins, interferons, hormones, and vaccines. Cells transfected with an apoptosis-inhibiting gene or vector, such as a triple mutant bcl-2 gene, can survive longer in culture, resulting in extension of the state and yield of protein biosynthesis.
10/16/14
20140308677
Proteins and method for detection of lyme disease
Recombinant b. Burgdorferi proteins, representative of the life cycle, are membrane-immobilized to capture antibodies in biological samples.
10/16/14
20140308657
Serine protease inhibitor kazal antibodies
This invention describes a relevant etiology of cancer and a novel anti-cancer therapeutic strategy, based on the discovery that a protein named serine protease inhibitor (spik/spink/psti) was up-regulated by hepatitis b and c virus infections consequently suppressing the cell apoptosis. Accordingly, this invention provides an inhibitor of spik and/or a technology of suppression of over-expression of spik in cells.
10/16/14
20140308342
Reprogramming urokinase into an antibody-recruiting anticancer agent
The present invention relates to chimeric (preferably, bifunctional) compounds, compositions comprising those compounds and methods of treating cancer in a patient or subject, especially including metastatic cancer where cancer cells exhibit overexpression (heightened expression) of cell surface urokinase-type plasminogen activator receptor (urokinase receptor) compared to normal (non-cancerous) cells. The compounds preferably covalently bind to the urokinase receptor and recruit native antibodies of the patient or subject where the antibodies can selectively degrade and/or deactivate targeted cancer cells through antibody-dependent cellular phagocytosis and/or antibody-dependent cellular cytotoxicity (adcc) against a large number and variety of cancers, thus providing cancer cell death and/or an inhibition of growth, elaboration and/or metastasis of the cancer, including remission and cure of the patient's cancer..
10/16/14
20140308308
Compositions and methods for treatment of cytomegalovirus
The present disclosure provides compositions and methods useful for treating hcmv infection. As described herein, the compositions and methods are based on development of immunogenic compositions that include virus-like particles (vlps) which comprise one or more moloney murine leukemia virus (mmlv) core proteins and include one or more hcmv epitopes, such as, for example, from hcmv envelope glycoproteins gb and/or gh and/or tegument protein pp65.
10/16/14
20140308302
Anti-5t4 antibodies and uses thereof
Anti-5t4 antibodies, anti-5t4 antibody/drug conjugates, and methods for preparing and using the same.. .
10/16/14
20140308301
Cd44 monoclonal antibody for the treatment of b-cell chronic lymphocytic leukemia and other hematological malignancies
Compositions including an antibody specific for cd44 are provided. These antibodies specifically bind to hematologic malignant cells.
10/16/14
20140308290
Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide
The invention features methods for preventing or treating visceral pain, including pain associated with functional bowel disorder, inflammatory bowel disease and interstitial cystitis, by administering an anti-cgrp antagonist antibody.. .
10/16/14
20140308288
Antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof
An antibody of the invention interacts with human dr5 to produce agonistic or antagonistic effects downstream of the receptor including inhibition of cell proliferation and apoptosis. Nucleic acid sequences and amino acid sequences of anti-dr5 antibodies have been elucidated and vectors and cells containing and expressing these sequences have been generated.
10/16/14
20140308285
Heterodimeric bispecific antibodies
Provided herein are heterodimeric bispecific antibodies that can mediate cytolysis of a target cell by an immune effector cell, nucleic acids encoding such antibodies, methods of making such antibodies, and methods of using such antibodies. These antibodies comprise two different polypeptide chains, each comprising two immunoglobulin variable regions and, optionally, a half life-extending moiety..
10/16/14
20140308281
Antibodies directed against the alpha chain of il7 receptor - their use for the preparation of drug candidates
The invention concerns antibodies directed against cd127, i.e. The alpha chain of the receptor for interleukin7 (il-7), especially the receptor for human il-7 expressed on human cells (designated human il-7r alpha or il-7ra) or the tslp receptor.
10/16/14
20140308279
Anti-erbb3 antibodies and uses thereof
The present invention provides antibodies that bind to erbb3 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human erbb3.
10/16/14
20140308278
Class i anti-cea antibodies and uses thereof
The present invention provides compositions and methods of use of humanized, chimeric or human class i anti-cea antibodies or fragments thereof, preferably comprising the light chain variable region cdr sequences sassrvsyih (seq id no:1); gtstlas (seq id no:2); and qqwsynppt (seq id no:3); and the heavy chain variable region cdr sequences dyyms (seq id no:4); fiankanghttdyspsvkg (seq id no:5); and dmgirwnfdv (seq id no:6). The class i anti-cea antibodies or fragments are useful for treating diseases, such as cancer, wherein the diseased cells express ceacam5 and/or ceacam6 antigens.
10/16/14
20140308276
Anti-ox40 antibodies and methods of using the same
Human antibodies, preferably recombinant human antibodies, both humanized and chimeric, which specifically bind to human ox40 are disclosed. Preferred antibodies have high affinity for ox40 receptor and activate the receptor in vitro and in vivo.
10/16/14
20140308273
Cell culture media and methods of antibody production
Cell culture media are provided herein as are methods of using the media for cell culture and antibody production from cells. Compositions comprising antibodies and fragments thereof, produced by the methods herein are also provided..
10/16/14
20140308271
Antibodies that bind to tl1a and their uses
The present invention relates to antibodies or fragments thereof that bind to tl1a. More specifically, the present invention relates to an antibody or fragment thereof that binds to tl1a comprising a heavy chain cdr1 comprising the amino acid sequence of seq id no: 51, and/or a heavy chain cdr2 comprising the amino acid sequence of seq id no: 52, and/or a heavy chain cdr3 comprising the amino acid sequence of seq id no: 53; and/or comprising a light chain cdr1 comprising the amino acid sequence of seq id no: 54, and/or a light chain cdr2 comprising the amino acid sequence of seq id no: 55 and/or a light chain cdr3 comprising the amino acid sequence of seq id no: 56..
10/16/14
20140308269
Humanized antibodies
Humanized antibodies that bind icam-1 are provided. Antibodies include those selected from: seq id no:1 and 3 (huma); seq id no:5 and 7 (humb); seq id no:9 and 11 (humc); seq id no:13 and 15 (humd); seq id no:17 and 19 (hume); seq id no:21 and 23 (humf); seq id no:25 and 27 (humg); seq id no:29 and 31 (humh); and seq id no:33 and 35 (humi).
10/16/14
20140308267
Neurotoxins exhibiting shortened biological activity
The present invention relates to the pharmaceutical field. Specifically, it contemplates a polynucleotide encoding a neurotoxin polypeptide exhibiting a reduced duration of the biological effect in a subject, wherein said polypeptide comprises at least one e3 ligase recognition motif in the light chain, wherein said e3 ligase recognition motif is preferably a binding motif for the e3 ligase mdm2.
10/16/14
20140308238
Immunomodulating compositions and methods of use thereof
The invention is directed to β1-6 glucans, compositions, diagnostic kits, and devices comprising the same, and methods of use thereof in modulating immune response and treating, delaying progression of, reducing the incidence or severity of cancer, infection, inflammation, and autoimmune diseases. The β1-6 glucans of certain embodiments of the invention are enriched for o-acetylated groups and/or conjugated to a solid support or linked to a targeting moiety.
10/16/14
20140308206
Fc receptor binding proteins
The disclosure relates to antibodies that bind fcrn and methods of using these antibodies.. .
10/16/14
20140308204
Free psa antibodies as diagnostics, prognostics and therapeutics for prostate cancer
The present invention provides methods of monitoring and measuring tumor-associated free psa (“fpsa”) with antibody polypeptides as an indication of androgen receptor signaling. In a particular embodiment, the methods may be used to assess the efficacy of anti-androgen and/or general anti-cancer treatments.
10/16/14
20140308201
Antibody drug conjugates
The present invention relates to anti-fgfr2 antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.. .
10/09/14
20140303355
Humanized anti-factor d antibodies and uses thereof
The invention relates to humanized anti-human factor d monoclonal antibodies, their nucleic acid and amino acid sequences, the cells and vectors that harbor these antibodies and their use in the preparation of compositions and medicaments for treatment of diseases and disorders associated with excessive or uncontrolled complement activation. These antibodies are useful for diagnostics, prophylaxis and treatment of disease..
10/09/14
20140303354
Anti-cd47 antibodies and methods of use thereof
The invention relates to monoclonal and/or monovalent antibodies that bind cd47. The invention relates to monoclonal and/or monovalent antibodies that bind cd19.


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Antibodies topics: Antibodies, Recombinant, Nucleic Acid, Nucleic Acids, Polypeptide, Therapeutics, Immunoglobulin, Immunoglobulins, Monoclonal, Radiation Therapy, Desmoplastic, Hypertension, Hypertensive, Immunotherapy, Photodynamic Therapy

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