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Antibodies

Antibodies-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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NEW Measuring circulating therapeutic antibody, antigen and antigen/antibody complexes using elisa assays
Board Of Regents, The University Of Texas System
February 15, 2018 - N°20180045736

The present invention relates to the field of immunology and hyperproliferative diseases. More specifically, the present invention relates to a method of detecting and monitoring therapeutic antibody:antigen complex, soluble antigen and soluble therapeutic antibody, wherein a patient has undergone at least one course of immunotherapy. Yet further, levels of therapeutic antibody:antigen complexes, soluble antigens or soluble therapeutic antibodies ...
NEW Chemically functionalized array to analyze protein modifications
Tymora Analytical Operations Llc
February 15, 2018 - N°20180045734

Methods and chemicals for the capture and analysis of a selected group of protein modifications. Post-translational modifications alter the functional groups in proteins. The resulting modified proteome is useful for biomarker discovery, clinical diagnostics, and protein dynamics. Present immunoassays to quantify modified proteins are limited by their dependence on antibodies, which are often not specific for post-translational modifications. This invention ...
NEW Methods of detecting inflammatory markers and treating inflammatory conditions in humans
Vetica Labs, Inc.
February 15, 2018 - N°20180045724

The present invention provides methods and systems to accurately detect and measure in a biological sample from a patient, endogenous antibodies, e. G., iga, to inflammatory proteins, which antibodies are useful as diagnostic markers for inflammatory conditions, including bowel disease (ibd), in patients. Such methods and systems identify whether a sample from the patient is associated with an inflammatory condition, ...
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NEW Stabilized formulations containing anti-pcsk9 antibodies
Regeneron Pharmaceuticals, Inc.
February 15, 2018 - N°20180044436

The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human proprotein convertase subtilisin/kexin type 9 (pcsk9). The formulations may contain, in addition to an anti-pcsk9 antibody, at least one amino acid, at least one sugar, or at least one non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability ...
NEW Novel anti-pad4 antibody
Pharma Foods International Co., Ltd.
February 15, 2018 - N°20180044434

Provided are anti-pad4 antibodies having excellent properties and an excellent method for treatment of ra. Used are anti-pad4 antibodies that specifically bind to an epitope containing positions 345, 347, and 348 of pad4. These anti-pad4 antibodies may inhibit the citrullination activity of pad4. In addition, these anti-pad4 antibodies may have a kd (m) of 9. 0×10−9 or less. Optionally, the anti-pad4 antibody and ...
NEW Human antibodies against tissue factor and methods of use thereof
Genmab A/s
February 15, 2018 - N°20180044431

Isolated human monoclonal antibodies which bind to human tf and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the antibodies, and therapeutic and diagnostic methods for using the antibodies.
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NEW Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions
Janssen Biotech, Inc.
February 15, 2018 - N°20180044427

The present invention relates to engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions.
NEW Use of il-31ra monoclonal antibodies for antagonizing signal transduction in dorsal root ganglion cells
Zymogenetics, Inc.
February 15, 2018 - N°20180044426

Use of antagonists to il-31ra and osmrb are used to treat inflammation and pain by inhibiting, preventing, reducing, minimizing, limiting or minimizing stimulation in neuronal tissues. Such antagonists include soluble receptors, antibodies and fragments, derivative, or variants thereof. Symptoms such as pain, tingle, sensitization, tickle associated with neuropathies are ameliorated.
NEW Novel antibodies and uses thereof
Cantargia Ab
February 15, 2018 - N°20180044425

The present invention provides an antibody or an antigen-binding fragment thereof with binding specificity for human interleukin-1 receptor accessory protein (il1rap) wherein the antibody or antigen-binding fragment is capable of inhibiting to domain 3 of human il1rap. The invention further provides the use of such antibodies or an antigen-binding fragments in the treatment and/or diagnosis of cancers, such ...
NEW Anti-cll-1 antibodies and immunoconjugates
Genentech, Inc.
February 15, 2018 - N°20180044421

The invention provides anti-cll-1 antibodies and immunoconjugates and methods of using the same.
NEW Anti-cll-1 antibodies and immunoconjugates
Genentech, Inc.
February 15, 2018 - N°20180044420

The invention provides anti-cll-1 antibodies and immunoconjugates and methods of using the same.
NEW Modified-igg antibodies that bind transforming growth factor-beta1 with high affinity, avidity and specificity
Genzyme Corporation
February 15, 2018 - N°20180044412

A modified igg antibody binds and neutralizes tgfβ1 selectively and with high affinity and avidity. The modified igg antibody comprises four polypeptide chains and may comprise modifications to the elbow regions of the polypeptide chains. The modified igg antibody may comprise the same vh and vl domains or cdr regions as metelimumab. The modified igg antibody is useful ...
NEW Angiopoietin-like 4 antibodies and methods of use
Novartis Ag
February 15, 2018 - N°20180044410

The present invention relates to monoclonal antibodies binding to human angiopoietin-like 4 protein (hereinafter, sometimes referred to as “angptl4”), and pharmaceutical compositions and methods of treatment comprising the same.
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  • 1876+ full patent PDF documents of Antibodies-related inventions.
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NEW Compositions and methods for improving resistance to breakage and eggshell strength
Wisconsin Alumni Research Foundation
February 15, 2018 - N°20180044390

Described herein are fgf-23 epitope peptides, methods of producing antibodies in laying hens by injecting the peptides, and methods of improving resistance to eggshell breakage and/or increasing eggshell strength by administering an fgf-23 epitope peptide to a laying hen.
NEW Tumor specific antibody conjugates and uses therefor
The University Of North Carolina At Charlotte
February 15, 2018 - N°20180043038

Provided are isolated antibodies, and fragments and derivatives thereof, which bind to tumor antigens. Provided are antibody/nanoparticle conjugates. Also provided are compositions and delivery agents that include the disclosed antibodies, conjugates, fragments and derivatives thereof; cells that produce the same; methods for producing the same; methods of using the same for detecting, targeting, and/or treating tumors and/or ...
NEW Amatoxin-antibody conjugates
Heidelberg Pharma Gmbh
February 15, 2018 - N°20180043033

The invention relates to conjugates comprising amatoxins and antibodies, in particular amatoxins linked to antibodies comprising specific cysteine residues.
NEW Compositions using antibodies directed to gpnmb and uses thereof
Celldex Therapeutics, Inc.
February 15, 2018 - N°20180043014

The present invention relates to antibodies, including fully human monoclonal antibodies, with specificity to gpnmb, and uses of such antibodies. The present invention further provides compositions that increase expression of gpnmb on the surface of tumor cells, and methods of using such compositions to increase the anti-cancer activity or other therapeutic efficacy of the antibodies and immunoconjugates provided herein.
NEW Antagonists of il-6 to raise albumin and/or lower crp
Alderbio Holdings Llc
February 15, 2018 - N°20180043010

The present invention is directed to therapeutic methods using il-6 antagonists such as antibodies and fragments thereof having binding specificity for il-6 to improve survivability or quality of life of a patient in need thereof. In preferred embodiments, the anti-il-6 antibodies will be humanized and/or will be aglycosylated. Also, in preferred embodiments these patients will comprise those exhibiting (or ...
NEW Galactose-pronged polysaccharides in a formulation for antifibrotic therapies
Galectin Therapeutics, Inc.
February 15, 2018 - N°20180042958

Methods and compositions for reducing fibrosis and cirrhosis are provided in which an effective dose of an admixture of a polysaccharide compound and, for example, a compound selected from the group consisting of antibodies specific to intracellular or cell-surface: (i) beta-pdgf receptors; (ii) synaptophysin; (iii) zvegf3; (iv) ccr1 receptors; (v) connective tissue growth factor; (vi) alpha 1-smooth muscle actin; (vii) ...
Human fc-bearing igg antibodies to polyethylene glycol
Bristol-myers Squibb Company
February 08, 2018 - N°20180038872

Polyethylene glycol (peg) is often conjugated with therapeutic proteins to enhance their pk properties. Peg may, however, be immunogenic, and the presence of peg in food and cosmetics is believed to result in pre-existing anti-peg antibodies in humans. Polyclonal and monoclonal antibodies reactive to peg are provided for use in immunogenicity assay development to detect such anti-drug antibodies. Such antibodies ...
Compositions and methods for the diagnosis of rheumatoid arthritis
Leiden University Medical Center
February 08, 2018 - N°20180038856

The present disclosure relates to the field of molecular biology and more specifically to methods for detecting anti-carbamylated protein (anti-carp) antibodies in the serum of rheumatoid arthritis (ra) patients.
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