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Antibiotics patents



      
           
This page is updated frequently with new Antibiotics-related patent applications. Subscribe to the Antibiotics RSS feed to automatically get the update: related Antibiotics RSS feeds. RSS updates for this page: Antibiotics RSS RSS


Mouthpiece and method for delivering nebulized medicament to the airway of a subject

Date/App# patent app List of recent Antibiotics-related patents
08/21/14
20140235855
 Tricyclic antibiotics patent thumbnailTricyclic antibiotics
Compounds of formula (i), wherein a1 represents —o—, —s— or —ch2—; a2 represents —ch2— or —o—; a3 represents c3-c8-cycloalkylene; saturated or unsaturated 4 to 8-membered heterocyclodiyl with 1, 2 or 3 heteroatoms selected from nitrogen or oxygen, which group a3 is unsubstituted or substituted; a4 represents c1-c4alkylene, —c(=0)-; g represents aryl or heteroaryl, which is unsubstituted or substituted; x1 represents a nitrogen atom or cr1; r1 represents a hydrogen atom or a halogen atom; r1 represents a hydrogen atom; m is 0 or 1; n is 1; the —(ch2)n— group is unsubstituted or substituted; p is 0 or 1; or pharmaceutically acceptable salts thereof are valuable for use as a medicament for the treatment of bacterial infections.. .
08/21/14
20140234889
 Method for neutralization of antibiotics in a culture medium patent thumbnailMethod for neutralization of antibiotics in a culture medium
The present invention is directed to a method and means for the neutralization, binding, and/or inactivation of antimicrobials in a test sample. The invention is also directed to a method of detecting the presence of one or more microorganisms in a test sample by culturing the test sample in a culture media comprising one or more primary amine-containing compounds..
08/21/14
20140234227
 Foam formulations patent thumbnailFoam formulations
The present invention provides foamable pharmaceutical compositions comprising water-soluble antibiotics and anti-inflammatory steroids and methods of preparing same. Particularly, the present invention relates to oil-free pharmaceutical compositions comprising a quinolone, an anti-inflammatory steroid, a polar co-solvent, and propellant gas, administered to the ear in the form of foam for treating ear disorders..
08/21/14
20140230811
 Mouthpiece and method for delivering nebulized medicament to the airway of a subject patent thumbnailMouthpiece and method for delivering nebulized medicament to the airway of a subject
A mouthpiece (10) is configured to be removably coupled with a nebulizer (12) to deliver nebulized medicament to the airway of a subject. The mouthpiece is configured to connect to the nebulizer in a swappable manner with another mouthpiece that is configured to operate in a continuous use mode.
08/14/14
20140228307
 Composition and method for treating an autoimmune disease patent thumbnailComposition and method for treating an autoimmune disease
A combination of antibiotics including rifabutin, clarithromycin and clofazimine for the treatment of an autoimmune disease such as multiple sclerosis and related diseases. In a further aspect, there is provided a composition comprising a combination of two or more antibiotic agents for the treatment of an autoimmune disease, said two or more antibiotic agents selected from rifabutin, clofazimine, and at least one macrolide..
08/14/14
20140228278
 Antibiotics and methods for manufacturing the same patent thumbnailAntibiotics and methods for manufacturing the same
The present invention generally relates to a novel highly discriminating antibiotic, plantazolicin, a plantazolicin-like compound and to pharmaceutical compositions comprising the same. Also provided are methods for producing and using plantazolicin.
08/07/14
20140221348
 Novel bicyclic antibiotics patent thumbnailNovel bicyclic antibiotics
X5 represents c—h or c—(c1-c6alkyl), c-halogen; a1, a2, a3, r1 and r4 represent various substituents, g represents aryl or heteroaryl, which is unsubstituted or substituted which compounds show good activity against pathogenic bacteria.. .
08/07/14
20140221330
 Ndm inhibitor patent thumbnailNdm inhibitor
An objective of the present invention is to provide a novel ndm (new delhi metallo-β-lactamase) inhibitor that functions as a drug for restoring the antibacterial activity of β-lactam antibiotics that have been inactivated as a result of decomposition by ndm. According to the present invention, there is provided an ndm inhibitor contains a compound represented by general formula (i):.
07/17/14
20140200197
 Hiv protease inhibitors patent thumbnailHiv protease inhibitors
The compounds encompassed by formula i include compounds which are hiv protease inhibitors and other compounds which can be metabolized in vivo to hiv protease inhibitors. The compounds and their pharmaceutically acceptable salts are useful for the prophylaxis or treatment of infection by hiv and the prophylaxis, treatment, or delay in the onset of aids.
07/10/14
20140193530
 Pharmaceutical composition containing honeysuckle extract and antibiotics, pharmaceutical kit, and use of honeysuckle extract for preparation of drug patent thumbnailPharmaceutical composition containing honeysuckle extract and antibiotics, pharmaceutical kit, and use of honeysuckle extract for preparation of drug
Provided is a pharmaceutical composition useful for prevention and/or treatment of diseases caused by bacteria, wherein the pharmaceutical composition comprising a honeysuckle extract containing iridoid compounds and an antibiotic. Also provided is a pharmaceutical kit comprising the honeysuckle extract containing the iridoid compounds and the antibiotics which are separately placed.
07/03/14
20140187512
Use of lactulose in the treatment of autism
A treatment for autism in which an effective amount of lactulose is administered in order to bind excess ammonia in the gastrointestinal tract, the bloodstream, and the nervous system in order to prevent or reverse ammonia poisoning caused by the administration of certain antibiotics. Lactulose molecules in the colon are fermented by certain bacteria.
07/03/14
20140187446
Affinity-based detection of biological targets
A method of biochemical identification by: providing a plurality of capture species bound to one or more substrates and suspected of having one or more biological targets affinity bound to at least one capture species; detecting which capture species contain bound biological targets to generate a binding pattern; and identifying the biological target based on the binding pattern. The capture species are independently selected from the group consisting of antimicrobial peptides, cytotoxic peptides, antibiotics, and combinations thereof.
07/03/14
20140186873
Synthesis and use of isotopically labeled macrocyclic compounds
Disclosed herein are isotopically labeled antifungal antibiotics and related compounds. Also disclosed are methods for synthesizing these isotopically labeled molecules and using the same to study the distribution of these compounds in the biosphere as well as the products formed by the breakdown of these isotopically labeled compounds..
06/26/14
20140179929
Synthesis of enone intermediate
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics.
06/26/14
20140179691
Novel oxazolidinone derivative and medical composition containing same
The novel oxazolidinone derivative, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically acceptable salt thereof have broad antibacterial spectrum against resistant bacteria, low toxicity and strong antibacterial effects against gram-positive and gram-negative bacteria and thus may be effectively used as antibiotics.. .
06/26/14
20140178971
Toxin-eating bacteria and bioremediation
Bacteria that can use antibiotics as a carbon source are provided. Methods and bacteria useful for bioremediation are also provided..
06/19/14
20140170207
Antimicrobial compounds and methods of use
The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections.
06/19/14
20140170125
Use of cardiotrophin-1 for the treatment of kidney diseases
The present invention relates to the use of cardiotrophin-1 (ct-1) for the prevention and/or treatment of acute renal injury, specially of acute kidney injury induced by nephrotoxic agents, such as contrast agents, antibiotics, immunosuppressive agents or antineoplastic agents. The invention is also related to compositions comprising said nephrotoxic agents and cardiotrophin-1..
06/12/14
20140163238
Synthesis of tetracyclines and analogues thereof
The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics.
06/12/14
20140162937
Polymyxin derivatives and uses thereof
The present invention relates to a polymyxin derivative and to a combination product comprising at least two such derivatives. The invention further relates to a method for treating, alleviating or ameliorating an infection in a subject caused by a gram-negative bacterium, by administering a therapeutically effective amount of a derivative according to the present invention to said subject; to a method for sensitizing gram-negative bacteria to an antibacterial agent by administering, simultaneously or sequentially in any order a therapeutically effective amount of said antibacterial agent and a derivative according to the present invention to said subject; to methods for developing novel antibiotics; for reducing the nephrotoxicity, for improving the pharmacokinetic properties of natural polymyxins and octapeptins; and for sensitizing clinically important bacteria to a host defense mechanism complement present in serum.
06/12/14
20140162314
High-yield peptide antibiotics producing strain, preparation method and use thereof
High-yield antibiotics producing strain, preparation method and use thereof are provided in the present invention. The high-yield strain is a mutagenized strain derived from colephoma empetri, and deposited in cgmcc with the accession number of cgmcc 4129.
06/12/14
20140159282
Method and device for producing temporary knee joint spacers with stems of various sizes
A cement mold assembly configured to form a temporary implant for use in delivering antibiotics to an infected site can includes a first mold and a second mold. The first mold can have an open end and an inner wall.
06/05/14
20140154317
Pharmaceutical composition for treatment of helicobacter pylori associated diseases
An oral pharmaceutical composition for the treatment of helicobacter pylori associated diseases is disclosed comprising a proton pump inhibitor, an antibiotic or a combination of antibiotics, and additionally at least one agent selected from the group consisting of a) taurolidine or taurultam or a combination thereof, b) a zinc amino acid chelate, c) tromethamole, within a fixed-dose combination for oral administration in the form of either an instant release formulation, for example a compressed tablet, granules or the like, or in the form of a biphasic release form, for example a tablet with a slow release core and a compressed outer fast release layer, wherein the tromethamole is always present in instant release formulations.. .
06/05/14
20140154236
Devices and methods for treating pain associated with tonsillectomies
Described here are devices and methods for treating one or more conditions or symptoms associated with a tonsil procedure. In some variations, a drug-releasing device may be at least partially delivered to one or more tonsillar tissues before, during, or after a tonsil procedure.
05/29/14
20140148595
Method for the preparation of carbapenam compounds
The subject of the present invention is a method of the preparation of compounds containing the core skeleton of carbapenem antibiotics, novel intermediate compounds used in this method, a method of the preparation of the intermediate compounds as well as the use of the intermediate compounds in the production of carbapenem antibiotics.. .
05/22/14
20140142144
Oxazolidinone compounds and their uses in preparation of antibiotics
The invention belongs to the field of medicaments, and particularly relates to oxazolidinone compounds and their uses in the preparation of antibiotics. A technical problem to be solved by the invention is to provide new oxazolidinone compounds having the structure represented by formula i.
05/22/14
20140142029
Macrocyclic broad spectrum antibiotics
Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. In various embodiments, the compounds act by inhibition of bacterial type 1 signal peptidase (spsb), an essential protein in bacteria.
05/15/14
20140134742
Effects of alteration of expression of the mtfa gene and its homologs on the production of fungal secondary metabolites
Many fungal secondary metabolites are of industrial interest, such as antibiotics, while others are undesirable compounds such as mycotoxins. Overexpression of mtfa enhances production of fungal compounds with applications in the medical field, and overexpression or impaired mtfa expression decreases the production of compounds that negatively affect health/agriculture/economy such as mycotoxins..
05/15/14
20140134671
Effects of alteration of expression of the mtfa gene and its homologs on the production of fungal secondary metabolites
Many fungal secondary metabolites are of industrial interest, such as antibiotics, while others are undesirable compounds such as mycotoxins. Overexpression of mtfa enhances production of fungal compounds with applications in the medical field, and overexpression or impaired mtfa expression decreases the production of compounds that negatively affect health/agriculture/economy such as mycotoxins..
05/15/14
20140134669
Polymyxin derivatives and uses thereof
The present invention relates to a polymyxin derivative wherein r1, r2 and r3 are optional and r1, r2, r3, r5, r8 and r9 are cationic or neutral amino acid residues selected so that the total number of positive charges at physiological ph is at least two but no more than three; and to a combination product comprising at least two such derivatives. The invention further relates to a method for treating, alleviating or ameliorating an infection in a subject, caused by a gram-negative bacterium by administering a therapeutically effective amount of a derivative according to the present invention to said subject; to a method for sensitizing gram-negative bacteria to an antibacterial agent by administering, simultaneously or sequentially in any order a therapeutically effective amount of said antibacterial agent and a derivative according to the present invention to said subject; to methods for developing novel antibiotics; for reducing the nephrotoxicity, for improving the pharmacokinetic properties of natural polymyxins and octapeptins; and for sensitizing clinically important bacteria to a host defence mechanism complement present in serum.
05/15/14
20140134213
Treatment of microbial infections
The present application relates to an anti-microbial system for use in the treatment of microbial infections or control of microbial contamination, which avoids the use of antibiotics. Such infections include mastitis, tuberculosis, cystic fibrosis and the contamination that may result from biofilm formation on medical devices..
05/15/14
20140134210
Composition containing antibiotics and lysophosphatidylcholine for boosting immunity or treatment of bacterial infections
The present invention relates to: a pharmaceutical composition containing lysophosphatidylcholine or analogs thereof and antibiotics as active ingredients for boosting immunity or the treatment of bacterial infections; a method for boosting immunity or the treatment of bacterial infections, which comprises a step for administering the composition; and a kit containing the composition for boosting immunity or the treatment of bacterial infections.. .
05/08/14
20140128359
N-heterocyclic substituent-containing antibiotic, preparation and use thereof
The invention relates to n-heterocyclic substituent-containing antibiotics, their preparation, and their use. Disclosed are sodium and potassium salts of 7-(α-((n,n′-diisopropylamidino)thio)acetylamino)-3-(((1,2,5,6-tetrahydro-2-methyl-5,6-diox o-1,2,4-triazin-3-yl)thio)methyl) cephalosporanic acid as presented by the general structure (i), their preparation, and their use.
05/08/14
20140128336
Medical products for use in conditions related to microbial infections in the upper aerodigestive tract
For use in connection with helicobacter pylori infections or other related infections, either as such or as combinations with antibiotics, whereby the compound(s) and optionally, when present, the antibiotic(s), are mixed with one or more pharmaceutically acceptable carriers providing sustained local release in the stomach or elsewhere in the upper aerodigestive tract.. .
05/08/14
20140127250
Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics..
05/01/14
20140121645
Methods and apparatus for the cvcs
The present invention provides an indirect method and accompanying apparatus for supplying a high concentration of medicaments, particularly antibiotics, to the nasal sinuses by first loading the medicament into the cerebrospinal venous system (cvcs) via a valsalva maneuver. Because the cvcs is a valveless, three-dimensional closed system, traditional physiological dogma such as veins always draining tissues does not always apply.
05/01/14
20140121273
Method for treatment of magnesium and potassium deficiencies
A method for the treatment of depleted intracellular and serum magnesium levels by administration of a highly bioavailable magnesium salt is disclosed. A prescription dispensing system is also disclosed.
04/24/14
20140113941
Thiolactone antibiotics
Or a pharmaceutically acceptable salt thereof.. .
04/17/14
20140106396
Mass spectrometric measurement of microbial resistances
Microorganisms, particularly bacteria, are identified and characterized on the basis of a mass spectrometric measurement of their protein profiles with ionization by matrix-assisted laser desorption. In order to measure the microbial resistance to antibiotics, the protein profiles of microorganisms are measured after cultivation for a short time duration in nutrient media containing the antibiotics..
04/17/14
20140105995
Silk fibroin systems for antibiotic delivery
The present invention provides for silk fibroin-based compositions comprising one or more antibiotic agents for prevention or treatment of microbial contamination, methods of making antibiotic-containing silk scaffold, methods of stabilizing antibiotics in silk scaffolds, and methods for preventing or treating microbial contamination using the antibiotic-containing compositions. Various methods may be used to embed the antibiotic(s) into the silk fibroin-based compositions.
04/17/14
20140105967
Stabilized composition and method for dermatological treatment
A stabilized, topical composition for the treatment of acne and other dermatological conditions comprises a liposomal formulation of a retinoid and an antibiotic in which the retinoid is disposed in the lipid phase of the formulation, and the antibiotic is disposed in the aqueous phase so as to be isolated from the retinoid. Lincosamides, such as clindamycin, are one group of antibiotics which may be used in the composition.
04/10/14
20140100231
Non-nucleoside reverse transcriptase inhibitors
Are hiv reverse transcriptase inhibitors, wherein r1, r2, re, l, m and z are defined herein. The compounds of formula i and their pharmaceutically acceptable salts are useful in the inhibition of hiv reverse transcriptase, the prophylaxis and treatment of infection by hiv and in the prophylaxis, delay in the onset or progression, and treatment of aids.
04/10/14
20140100198
Enzyme inhibiting compounds and methods
The invention provides compounds, compositions, and methods for studying the rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan infection, such as malaria.
04/10/14
20140100157
Method of inhibiting clostridium difficile by administration of oritavancin
Glycopeptide antibiotics, such as oritavancin, demonstrate significant activity against both a vegetative form of c. Difficile and c.
04/10/14
20140099679
System and method for producing biomaterials
A bioreactor system for manufacturing and extracting a desired biomaterial from a microorganism by fermenting the microorganism in the bioreactor. The system includes a horizontal reactor vessel, one or more vertical discs rotatably mounted around a hollow shaft, a motor to power the shaft, and one or more spray nozzles arranged to spray required liquids on to the discs.
04/03/14
20140094402
Lantibiotic nai-802, pharmaceutically acceptable salts, compositions and uses thereof
The present invention concerns novel lantibiotic compounds, processes for the isolation and preparation thereof, pharmaceutical compositions containing the same, pharmaceutical acceptable salts thereof, and methods of use of the lantibiotics as antibacterial agents.. .
04/03/14
20140093982
Measurement method and measurement kit of antibiotics concentration
A method and kit for measuring a concentration of an antibiotic are provided. The method of measuring a concentration of an antibiotic includes preparing magnetic particles bound to an antibiotic, preparing silica-coated fluorescent particles to which at least one antibody of the antibiotic is bound, allowing the magnetic particles to react with the silica-coated fluorescent particles, and irradiating the reacted silica-coated fluorescent particles with laser beams..
04/03/14
20140093550
Nanoparticle - biocide treatment of biofilms
A system of stabilized metallic nanoparticles is described that includes metallic nanoparticles coated with a hydrophilic polymer that has been reacted with a catechol-based ligand. Also described are stable, metallic nanoparticles that can be used alone or in conjunction with biocides, antibiotics, or other treatment systems in a method to disrupt a biofilm and facilitate its removal from a surface.
03/27/14
20140088116
Novel solid forms of antibiotics
The invention relates to novel solid forms of fluoroquinolones, in particular to complex co-crystals and to solvates, hydrates and polymorphs thereof. These substances can be used to prepare a pharmaceutical composition containing same as an active ingredient, which can be used as an antibiotic.
03/27/14
20140087425
Methods for preparing purified lipopeptides
The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics.
03/27/14
20140086865
Antimicrobial constructs
The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as pluronic® f108 or an end group activated polymer (egap) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection.
03/27/14
20140086857
Compositions comprising siloxane polymer
Compositions comprising siloxane polymers are disclosed. The compositions are useful as thixotropic bases for a variety of components, such as antimicrobial agents, sterilants, medicaments, antibiotics, analgesics, essential oils, preservatives, colorants, fragrances, and the like.
03/20/14
20140079671
Antibacterial phage, phage peptides and methods of use thereof
The present invention is directed to the field of phage therapy for the treatment and control of bacterial infections. In particular, the present invention is directed to the novel bacteriophage f387/08, f391/08, f394/08, f488/08, f510/08, f44/10, and f125/10, isolated polypeptides thereof, compositions comprising one or more of the novel bacteriophage and/or isolated polypeptides, as well as to methods for the treatment and prevention of bacterial infections using same, either alone or in combination with other antibacterial therapies, e.g., antibiotics and/or other phage therapies..
03/06/14
20140066409
Cyclohexane compounds and their use as antibiotics
The present invention relates to compounds according to general formula (i), pharmaceutical compositions comprising compounds according to general formula (i) and the use of the compounds for the treatment of a bacterial infection, particularly for use as an antibiotic.. .
03/06/14
20140065198
Medical implants and methods for regulating the tissue response to vascular closure devices
Devices and methods for reducing, eliminating, preventing, suppressing, or treating tissue responses to hemostatic devices e.g., biological sealants or vascular procedures are disclosed. The invention employs a combination of resorbable, biocompatible matrix materials and a variety of therapeutic agents, such as antiproliferatives or antibiotics, applied to a vascular puncture or incision to achieve hemostasis following diagnostic or interventional vascular catheterizations and to treat neointimal hyperplasia and stenosis.
03/06/14
20140065127
Staphylococcus haemolyticus prophage phish2 endolysin is lytic for staphylococcus aureus
Methicillin-resistant (mrsa) and multi-drug resistant strains of staphylococcus aureus are becoming increasingly prevalent in both human and veterinary clinics. S.
02/27/14
20140053830
Methods, devices and formulations for targeted endobronchial therapy
The present invention provides an improved means of treating tracheobronchitis, bronchiectasis and pneumonia in the nosocomial patient, preferably with aerosolized anti gram-positive and anti-gram negative antibiotics administered in combination or in seriatim in reliably sufficient amounts for therapeutic effect. In one aspect, the invention assures this result when aerosol is delivered into the ventilator circuit.
02/20/14
20140051670
Compositions containing moxifloxacin for treating otic infections
Ophthalmic, otic and nasal compositions containing a new class of antibiotics (e.g., moxifloxacin) are disclosed. The compositions preferably also contain one or more anti-inflammatory agents.
02/20/14
20140050747
Trace elements
The invention discloses a trace element solution, which comprises at least one metal selected from the group comprising selenium, copper, zinc, manganese and chromium; and at least one component selected from the group comprising a vitamin, a vaccine, a growth stimulant, a dewormer, iron dextran, an antibiotic and a synchronisation preparation. The synchronisation preparation is a combination of injectable hormonal preparations, inplantable hormonal preparations, intravaginal hormonal preparation and other slow release hormonal preparation.
02/13/14
20140045930
Assay for arginyl hydroxylase activity
The present invention relates to assays for monitoring activity of ycfd activity, in particular, to assays for identifying modulators of ycfd activity. The present invention also relates to the use of ycfd inhibitors as antibiotics.
02/06/14
20140038297
Genes and proteins for the biosynthesis of the lantibiotic 107891
The invention relates to the field of lantibiotics, and more specifically to the isolation of nucleic acid molecules that code for the enzymes required for the biosynthetic pathway of the lantibiotic 107891 and the homologues thereof.. .
02/06/14
20140037587
Beneficial effects of bacteriophage treatments
The invention relates to use of one or more bacteriophages in vivo in a human or animal in order to induce sensitivity to chemical antibiotics in bacterial cells, where such susceptibility is heritable, independent of continuing bacteriophage metabolism within those cells, and does not relate to the destruction of a biofilm to induce such sensitivity.. .
01/30/14
20140031523
Selective poly-n-substituted glycine antibiotics
Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.. .
01/30/14
20140031451
Paste-like bone cement
A paste contains at least one monomer for radical polymerisation, at least one polymer that is soluble in said at least one monomer for radical polymerisation, and at least one filling agent that is poorly soluble or insoluble in said at least one monomer for radical polymerisation. The filling agent is a particulate inorganic calcium salt comprising the following properties: at least 90% by weight of the particulate inorganic calcium salt have a particle size of less than 63 μm, as determined by means of sieve analysis; and the solubility in water of the particulate inorganic calcium salt at 20° c.
01/30/14
20140030712
Genomic approach to the identification of biomarkers for antibiotic resistance and susceptibility in clinical isolates of bacterial pathogens
In certain embodiments, the present invention concerns genotypic identification of bacteria that are resistant to a bacteria and subsequent determination of an appropriate therapy. In specific embodiments, a high-throughput genotypic detection method for biomarkers for antibiotic resistance and susceptibility allows efficient prescription practice and increases the likelihood of a successful therapeutic outcome.
01/23/14
20140024739
Paste-like bone cement
Paste containing at least one monomer for radical polymerization, at least one polymer that is soluble in said at least one monomer for radical polymerization, and at least one filling agent that is poorly soluble or insoluble in said at least one monomer for radical polymerization, wherein the filling agent is a particulate inorganic filling agent possessing a bet surface of at least 40 m2/g; kit comprising pastes a and b which, when mixed, form paste c, which pastes are useful for mechanical fixation of articular endoprostheses, for covering skull defects, for filling bone cavities, for femuroplasty, for vertebroplasty, for kyphoplasty, for the manufacture of spacers or for the production of carrier materials for local antibiotics therapy, as well as a form body produced from the pastes.. .
01/23/14
20140024577
Methods for preparing purified lipopeptides
The present invention relates to crystalline and crystal-like forms of lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics. The present invention relates to methods of purifying lipopeptides, including daptomycin, a lipopeptide antibiotic with potent bactericidal activity against gram-positive bacteria, including strains that are resistant to conventional antibiotics.
01/23/14
20140023814
Potable water containers having surfaces including heat labile component/carrier combinations and methods for their preparation
Containers for the storage and/or transport of potable water having surfaces derived from a range of polymers are provided. The container's surfaces may include a component/carrier combination (typically a heat labile component) which affords thermal stability to the surface containing the component.
01/16/14
20140018326
Sulfonamides as hib protease inhibitors
Compounds of formula i are disclosed: wherein l, a, r1, r2, r3a, r3b, r4a, r4b, r5, r6 and r7 are defined herein. The compounds encompassed by formula i include compounds which are hiv protease inhibitors and other compounds which can be metabolized in vivo to hiv protease inhibitors.
01/16/14
20140018325
Hiv protease inhibitors
Compounds of formula i are disclosed wherein r1, r2, r3a, r3b, r4a, r4b, r5a, r5b, r6a, r6b, r8 and r9 are defined herein. The compounds encompassed by formula i include compounds which are hiv protease inhibitors and other compounds which can be metabolized in vivo to hiv protease inhibitors.
01/16/14
20140018312
Steroid alkaloids and uses thereof as antimicrobial agents against electron transport-deficient microbes and as potentiators for antimicrobial agents against pathogenic bacteria
The present invention includes novel compounds based on the tomatidine skeleton as well as composition comprising these compounds alone and in combination with known compounds, which exhibit antimicrobial activity against extracellular or intracellular electron transport-deficient microbes and/or increase the antimicrobial activity of aminoglycoside antibiotics against their targets, and which are useful as antibacterial agents for treatment or prophylaxis of monomicrobiotic or polymicrobic bacterial infections or for the reduction of antibiotic resistance development in animals or in humans, or for use as antiseptics or agents for sterilization or disinfection.. .


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Antibiotics topics: Antibiotic, Antibiotics, Vancomycin, Daptomycin, Bacterial Infections, Bacterial Infection, Enterococcus, Staphylococcus, Acne Vulgaris, Membranous, Methicillin, Acne Treatment, Chromatograph, Chromatography, Streptomyces

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