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Angiopoietin patents



      
           
This page is updated frequently with new Angiopoietin-related patent applications. Subscribe to the Angiopoietin RSS feed to automatically get the update: related Angiopoietin RSS feeds. RSS updates for this page: Angiopoietin RSS RSS


Date/App# patent app List of recent Angiopoietin-related patents
07/17/14
20140199378
 New natural and synthetic compounds for treating cancer and other diseases patent thumbnailNew natural and synthetic compounds for treating cancer and other diseases
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti-adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
07/10/14
20140193825
 Modulation of angiopoietin-like 3 expression patent thumbnailModulation of angiopoietin-like 3 expression
Provided herein are methods, compounds, and compositions for reducing expression of an angptl3 mrna and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal.
06/26/14
20140179768
 Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof patent thumbnailAngiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
The invention relates to double-stranded ribonucleic acid (dsrna) compositions targeting the angptl3 gene, as well as methods of inhibiting expression of angptl3 and methods of treating subjects having a disorder of lipid metabolism, such as hyperlipidemia or hypertriglyceridemia, using such dsrna compositions.. .
05/29/14
20140148385
Composition for preventing or treating erectile dysfunction comprising angiopoietin-4 protein
Provided is a composition for preventing or treating erectile dysfunction including angiopoietin-4 protein as an active ingredient. Angiopoietin-4 protein increases an endothelial cell-specific protein level to induce regeneration of penile vascular endothelial cells, thereby increasing intracavernous pressure.
05/29/14
20140147864
 Methods and compositions for diagnosis and prognosis of renal injury and renal failure patent thumbnailMethods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of proheparin-binding egf-like growth factor, tenascin c, angiopoietin-related protein 4, fibroblast growth factor 19, fibroblast growth factor 21, heparin-binding growth factor 1, angiopoietin-related protein 6, proepiregulin, probetacellulin, amphiregulin, angiogenin, thrombospondin-2, and collagen alpha-1 (xviii) chain as diagnostic and prognostic biomarkers in renal injuries..
04/24/14
20140113858
 Peptide for inhibition of binding between angiopoietin-2 and integrin and use thereof patent thumbnailPeptide for inhibition of binding between angiopoietin-2 and integrin and use thereof
There are provided an angiopoietin-2 (ang2) derived peptides, polypeptides, and peptide complexes, and a method for inhibition of binding between ang2 and integrin and prevention and/or treatment of a disease caused by the activation of ang2 or the binding between ang2 and integrin using the peptide, polypeptides, and peptide complexes.. .
04/24/14
20140112933
 Antibodies against angiopoietins 1 and 2, and their use patent thumbnailAntibodies against angiopoietins 1 and 2, and their use
The present invention relates to antibodies against angiopoietins 1 and 2, and derivatives of these antibodies. More specifically, the present invention relates to therapeutic use of the antibodies and fragment thereof which specifically bind to angiopoietins 1 and 2..
04/24/14
20140112930
 Methods for treating or preventing malaria by administering an antibody that specifically binds angiopoietin-2 (ang-2) patent thumbnailMethods for treating or preventing malaria by administering an antibody that specifically binds angiopoietin-2 (ang-2)
The present invention provides methods for treating or preventing malaria by administering to a patient in need thereof a pharmaceutical composition comprising an antibody that specifically binds human angiopoietin-2 (ang-2).. .
04/03/14
20140093499
 Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents patent thumbnailPharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf agents
The present invention relates to pharmaceutical combinations comprising dual angiopoietin-2/dll4 binders and anti-vegf agents for use in treating diseases like cancer and ocular diseases.. .
04/03/14
20140093498
 Pharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents patent thumbnailPharmaceutical combinations comprising dual angiopoietin-2 / dll4 binders and anti-vegf-r agents
The present invention relates to pharmaceutical combinations comprising dual angiopoietin-2/dii4 binders and anti-vegf-r agents for use in treating diseases like cancer and ocular diseases.. .
03/06/14
20140065707
Antibodies against human angiopoietin 2
The present invention relates to antibodies against human angiopoietin 2 (anti-ang-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.. .
03/06/14
20140065151
Antibodies against human angiopoietin 2
The present invention relates to a method of treating a disease or disorder in a patient comprising administering, to a patient in need of such treatment, an antibody which binds specifically to human angiopoietin-2 (ang-2). The present invention also relates to a method for preventing metastasis in a patient suffering from primary cancer comprising administering, to a patient in need of such preventative treatment, an antibody which binds specifically to human angiopoietin-2 (ang-2)..
02/06/14
20140037640
Composition comprising expression or activity inhibitors of ninjurin1 for the prevention and treatment of inflammatory disease
The present invention relates to a composition comprising a ninjurin1 expression or activity inhibitor for the prevention and treatment of inflammatory disease. Ninjurin1 protein is specifically expressed in macrophages around blood vessels, increases cell-cell adhesion and cell-matrix adhesion, increases expressions of wnt7b (wingless-type mmtv integration site family, member 7b) and ang2 (angiopoietin-2), but reduces expression of ang1 to induce apoptosis of vascular endothelial cells.
01/23/14
20140024113
Compounds for treating cancer and other diseases
This invention provides a method of synthesizing new active compounds for pharmaceutical uses including cancer treatment, wherein the cancers comprise breast, leukocytic, liver, ovarian, bladder, prostatic, skin, bone, brain, leukemia, lung, colon, cns, melanoma, renal, cervical, esophageal, testicular, spleenic, kidney, lymphatic, pancreatic, stomach and thyroid cancers. This invention is an anti adhesion therapy which uses the compound as a mediator or inhibitor of adhesion proteins and angiopoietins.
01/23/14
20140023654
Combination of angiopoietin-2 antagonist and of vegf-a, kdr and/or flt1 antagonist for treating cancer
The invention relates to agents which possess anti-angiogenic activity and are accordingly useful in methods of treatment of disease states associated with angiogenesis in the animal or human body. More specifically the invention concerns a combination of an antagonist of the biological activity of angiopoietin-2 and an antagonist of the biological activity of vegf-a, and/or kdr, and/or flt1, and uses of such antagonists..
01/16/14
20140017784
Methods for expansion and analysis of cultured hematopoietic stem cells
Methods and kits for propagating hematopoietic stem cells are provided. The methods comprise culturing cells in medium comprising one or more angiopoietin-like proteins, under conditions sufficient for expansion of hscs.
01/16/14
20140017244
Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases
The present invention relates to bispecific antibody against human vascular endothelial growth factor (vegf/vegf-a) and against human angiopoietin-2 (ang-2) of human igg1 or igg4 subclass with mutations i253a, h310a, and h435a, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.. .
01/02/14
20140004175
Angiopoietin derived peptides
Provided are angiopoietin-derived peptides or homologs or derivatives thereof, pharmaceutical composition including them, a use thereof for therapy and for the manufacture of a medicament, a method of treating a wide range of conditions, disorders and diseases therewith, nucleotide sequences encoding them, antibodies directed to epitopes thereof and fusion proteins including them.. .
12/19/13
20130338089
Methods and compounds for modulating the secretion or expression of adhesion proteins or angiopoietins of cells
This invention provides methods, processes, compounds and compositions for modulating the gene expression or secretion of adhesion proteins, angiopoietins or their receptors to cure diseases, for anti-angiogenesis and for treating parasites, wherein the adhesion proteins or receptors comprise fibronectin, integrins family, myosin, vitronectin, collagen, laminin, glycosylation cell surface proteins, polyglycans, cadherin, heparin, tenascin, cd 54, cam, elastin and fak; wherein the angiopoietins comprise angiopoietin 1, angiopoietin 2, angiopoietin 3, angiopoietin 4, angiopoietin 5, angiopoietin 6, angiopoietin 7, angiopoietin-like 1, angiopoietin-like 2, angiopoietin-like 3, angiopoietin-like 4, angiopoietin-like 5, angiopoietin-like 6, and angiopoietin-like 7; wherein the cancers comprise breast cancer, leukocyte cancer, liver cancer, ovarian cancer, bladder cancer, prostate cancer, skin cancer, bone cancer, brain cancer, leukemia cancer, lung cancer, colon cancer, cns cancer, melanoma cancer, renal cancer, cervical cancer, esophageal cancer, testicular cancer, spleenic cancer, kidney cancer, lymphatic cancer, pancreas cancer, stomach cancer and thyroid cancer.. .
12/19/13
20130336992
Antibodies directed to angiopoietin-1 and angiopoietin-2 and uses thereof
Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin 1 and/or angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and cdrs of the antibodies, as well as methods of making and using the antibodies..
12/12/13
20130330752
Methods and compositions for diagnosis and prognosis of renal injury and renal failure
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of angiopoietin-related protein 3, soluble lymphatic vessel endothelial hyaluronic acid receptor 1, and vascular endothelial growth factor d as diagnostic and prognostic biomarkers in renal injuries..
10/24/13
20130280251
Stabilized angiopoietin-2 antibodies and uses thereof
Stabilized antibodies directed to angiopoeitin-2 and uses of such antibodies are described. Nucleic acid and amino acid sequences, hybridomas or other cell lines for expressing such antibodies are also provided..
10/10/13
20130266574
Human antibodies to human angiopoietin-like protein 4
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits human angiopoietin-like protein 4 (hangptl4) is provided. The human anti-hangptl4 antibodies are useful in treating diseases or disorders associated with angptl4, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth.
09/26/13
20130252821
Methods and compositions for the treatment and diagnosis of diseases characterized by vascular leak, hypotension, or a procoagulant state
Disclosed herein are methods for treating a vascular leak disorder, hypotension, or a procoagulant state using angiopoietin-2 (ang-2) antagonist compounds. Also disclosed are methods for treating a vascular leak disorder associated with high dose il-2 therapy using angiopoietin-2 antagonist compounds.
08/15/13
20130209492
Anti-tie2 antibodies and uses thereof
The present invention provides antibodies that bind to tie2 and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human tie2 and block the interaction between tie2 and one or more tie2 ligands such as angiopoietin 1 (ang1), angiopoietin 2 (ang2), angiopoietin 3 (ang3) and/or angiopoietin 4 (ang4).
07/25/13
20130186797
Stabilized formulations containing anti-ang2 antibodies
The present invention provides pharmaceutical formulations comprising an antibody that specifically binds to angiopoietin 2 (ang-2). The formulations may contain, in addition to an anti-ang-2 antibody, at least one amino acid, at least one sugar, or at least one non-ionic surfactant.
07/04/13
20130171160
Antibodies directed to angiopoietin-2 and uses thereof
Antibodies directed to the antigen ang-2 and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen ang-2.
07/04/13
20130171149
Anti-angptl3 antibodies and uses thereof
A fully human antibody or antigen-binding fragment of a human antibody that specifically binds and inhibits or interferes with at least one activity of human angiopoietin-like protein 3 (hangptl3) is provided. The human anti-hangptl3 antibodies are useful in treating diseases or disorders associated with angptl3, such as hyperlipidemia, hyperlipoproteinemia and dyslipidemia, including hypertriglyceridemia, hypercholesterolemia, chylomicronemia, and so forth.
06/20/13
20130158234
Specific binding agents of human angiopoietin-2
Disclosed are peptides that bind to ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies..
06/20/13
20130156789
Antibodies against human angiopoietin 2
(b) a light chain variable domain which comprises a cdr3 region of seq id no: 4, a cdr2 region of seq id no: 5 and a cdr1 region of seq id no: 6.. .
06/06/13
20130142799
Angiopoietin-2 specific binding agents
Disclosed are specific binding agents, such as fully human antibodies, that bind to angiopoietin-2. Also disclosed are heavy chain fragments, light chain fragments, and cdrs of the antibodies, as well as methods of making and using the antibodies..
05/23/13
20130129722
Methods for treating cancer by administering an anti-ang-2 antibody
The present invention provides antibodies that bind to angiopoietin-2 (ang-2) and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human ang-2.
03/07/13
20130059771
Function and regulation of angiopoietin-3/angiopoietin-4
The present invention relates to angiopoietin-3 (ang-3) and angiopoietin-4 (ang-4). The present invention also relates to methods of modulating an activity of ang-3 or ang-4.
02/28/13
20130052168
Methods and compositions for tissue regeneration
A kit is disclosed that includes a first component comprising alginate, wherein the first component is comprised in a first sterile vial, and a second component comprising cells comprising keratinocytes or fibroblasts, or mixtures thereof, that secrete one or more biologically active molecules selected from the group consisting of gm-csf, vegf, kgf, bfgf, tgfβ, angiopoietin, egf, il-iβ, il-6, il-8, tgfα, and tnfα, wherein the cells are allogeneic and mitotically inactive, a buffered solution, and human serum albumin or a cryoprotectant, wherein the second component is comprised in a second sterile vial.. .
01/24/13
20130023579
Modulation of angiopoietin-like 3 expression
Provided herein are methods, compounds, and compositions for reducing expression of an angptl3 mrna and protein in an animal. Also provided herein are methods, compounds, and compositions for reducing plasma lipids, plasma glucose and atherosclerotic plaques in an animal.


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Angiopoietin topics: Angiopoietin, Antibodies, Amino Acid, Cardiovascular Disease, Vascular Disease, Cardiovascular, Nucleic Acid, Pancreatitis, Nonalcoholic Steatohepatitis, Risk Factor, Metabolism, Steatohepatitis, Lipoprotein, Vascular Diseases, Coronary Artery

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This listing is a sample listing of patent applications related to Angiopoietin for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Angiopoietin with additional patents listed. Browse our RSS directory or Search for other possible listings.
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