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Angioedema

Angioedema-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Bispecific antibodies against plasma kallikrein and factor xii
Dyax Corp.
May 03, 2018 - N°20180118851

Described herein are bispecific antibodies that bind to plasma kallikrein (pkal) and factor xii and methods of producing and using such bi-specific antibodies for treating diseases or disorders associated with the contact system, e. G., hereditary angioedema or thrombosis. One aspect of the present disclosure is a bispecific antibody, comprising: a first polypeptide that comprises a light chain of a ...
Enzyme formulation for reducing histamine intolerance
May 03, 2018 - N°20180117130

Disclosed is a formulation of the following enzymes: alpha-galactosidase, alpha amylase, beta glucanase, lactase, biocor dpp=iv (proprietary blend) and pectinase, which has been found to be effective in treating histamine intolerant people, and causing a significant improvement in a wide variety of pathologies and symptoms, including, but not limited to: inflammation, pruritus, urticaria, hypotension, tachycardia, fatigue, migraines, conjunctivitis, incontinence, ...
Factor xii (hageman factor) (f12), kallikrein b, plasma (fletcher factor) 1 (klkb1), and kininogen 1 (kng1) irna ...
Alnylam Pharmaceuticals, Inc.
April 12, 2018 - N°20180100150

The present invention relates to rnai agents, e. G., double stranded rnai agents, targeting the kallikrein b, plasma (fletcher factor) 1 (klkb1) gene, the factor xii (hageman factor (f12) gene, or the kininogen 1 (kng1) gene, and methods of using such rnai agents to inhibit expression of a klkb1 gene, an f12 gene, and/or a kng1 gene, and methods of treating ...
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Conjugated c1 esterase inhibitor and uses thereof
Shire Human Genetic Therapies, Inc.
December 21, 2017 - N°20170360905

The present invention provides, among other things, a conjugated c1-inh for improved treatment of complement-mediated disorders, including hereditary angioedema (hae). In some embodiments, a conjugated c1-inh provided by the present invention is a pegylated c1-inh. In some embodiments, a conjugated c1-inh provided by the present invention is a polysialic acid (psa) conjugated c1-inh.
Piperidinylpyrazolopyrimidinones and their use
Bayer Pharma Aktiengesellschaft
November 23, 2017 - N°20170334917

The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is ...
Enzyme formulation for reducing histamine intolerance
September 28, 2017 - N°20170274056

Disclosed is a formulation of the following enzymes: alpha-galactosidase, alpha amylase, beta glucanase, lactase, biocor dpp=iv (proprietary blend) and pectinase, which has been found to be effective in treating histamine intolerant people, and causing a significant improvement in a wide variety of pathologies and symptoms, including, but not limited to: inflammation, pruritus, urticaria, hypotension, tachycardia, fatigue, migraines, conjunctivitis, incontinence, ...
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Therapeutic inhibitory compounds
Lifesci Pharmaceuticals, Inc.
September 14, 2017 - N°20170260163

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.
(aza)pyridopyrazolopyrimidinones and indazolopyrimidinones and their use
Bayer Pharma Aktiengesellschaft
August 24, 2017 - N°20170239251

The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein ...
Pharmaceutical composition for preventing or treating angioedema, containing extract of peony root or mixture of ...
Korea Institute Of Oriental Medicine
July 27, 2017 - N°20170209510

The present invention relates to a pharmaceutical composition for preventing or treating angioedema, containing as an active ingredient a peony root extract or an extract of a mixture of peony root and licorice. In particular, the extract of a mixture of peony root and licorice according to the present invention inhibits the excessive generation of advanced glycation end products, which ...
Pharmaceutical composition for preventing or treating diabetic complications and angioedema, containing natural mixture extract as ...
Korea Institute Of Oriental Medicine
June 29, 2017 - N°20170182107

The extract of a mixture of cinnamon twig and moutan root bark, cinnamon twig and peony root, or cinnamon twig and poria according to the present invention has been confirmed to inhibit the excessive generation of advanced glycation end-products, which occurs under chronic diabetic conditions, exhibit the effect of fragmentizing a cross-link between the advanced glycation end-products and matrix proteins, ...
Composition of allergen extracts having reduced toxicity and method of production thereof
Stallergenes
June 08, 2017 - N°20170157240

The present invention concerns pollen allergen extracts, in particular ragweed (ambrosia) pollen allergen extracts, containing reduced amounts of copper-binding-like proteins in order to minimize the risk of toxicity, including induction of angioedema, of those allergen extracts. The invention also relates to methods of preparing pollen allergen extracts containing reduced amounts of copper-binding-like proteins.
Humanized anti-ige antibodies that crosslink cd23 on b lymphocytes but do not sensitize mast cells
Academia Sinica
May 04, 2017 - N°20170121425

A novel humanized anti-ige antibody is disclosed. The antibody is capable of binding to free ige, membrane-bound ige on b lymphocytes, ige bound by cd23, but not to ige bound by high-affinity ige. Fc receptor on mast cells. The present invention relates to the treatment of ige-mediated diseases, including allergic asthma, allergic rhinitis, atopic dermatitis, food allergy, chronic spontaneous (idiopathic) ...
Therapeutic inhibitory compounds
Lifesci Pharmaceuticals, Inc.
February 02, 2017 - N°20170029406

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.
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Treatment of hereditary angioedema with c1 inhibitor
Santarus, Inc.
December 15, 2016 - N°20160361394

A method for treating acute attacks of hereditary angioedema (hae) whereby a first does and a second dose of a recombinant c1 esterase inhibitor is administered intravenously to the patient, each dose at 50 iu/kg body weight of the patient and wherein the first and second doses are administered within a 24 hour period. The recombinant c1 esterase inhibitor has an ...
Adeno-associated virus mediated delivery of c1ei as a therapy for angioedema
Cornell University
December 01, 2016 - N°20160347822

This invention is directed to a vector which comprises a promoter operably linked to a nucleic acid sequence encoding the human c1 esterase inhibitor or factor xii. The invention is also directed to a composition comprising the vector and a method of using the vector to treat or prevent hereditary angioedema.
Compositions and methods for inhibiting gene expression of factor xii
Arrowhead Madison Inc.
September 22, 2016 - N°20160272978

Rna interference (rnai) triggers for inhibiting the expression of factor xii (f12) gene through the mechanism of rna interference are described. Pharmaceutical compositions comprising one or more f12 rnai triggers together with one or more excipients capable of delivering the rnai trigger(s) to a liver cell in vivo are also described. Delivery of the f12 rnai trigger(s) to ...
Therapy for chronic idiopathic urticaria, anaphylaxis and angioedema
September 22, 2016 - N°20160271112

Methods for treating or relieving at least one symptom of urticarial disorders including chronic idiopathic urticaria, angioedema, and anaphylaxis, or a combination of these disorders in a mammal, including humans. The method comprises administering to the mammal a therapeutically effective amount of pramipexole, dexpramipexole or pharmaceutically acceptable salts thereof.
Therapeutic inhibitory compounds
Lifesci Pharmaceuticals, Inc.
July 14, 2016 - N°20160200704

Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases wherein the inhibition of plasma kallikrein inhibition has been implicated, such as angioedema and the like.
Methods of treating b2-bradykinin receptor mediated angioedema
Shire Human Genetic Therapies, Inc.
February 04, 2016 - N°20160030416

Methods of treating b2-bradykinin receptor mediated angioedema in a subject by administering a composition containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate thereof. Oral formulations containing a 8-(heteroarylmethoxy)quinolone compound, a 8-(arylmethoxy)quinoline compound, or a salt, a stereoisomer, a hydrate, or a solvate ...
Evaluation and treatment of bradykinin-mediated disorders
Dyax Corp.
December 17, 2015 - N°20150362493

The present disclosure provides methods of evaluating a subject, e. G., a subject at risk for or suffering from a pkal-mediated or bradykinin-mediated disorder, based on values (e. G., percentages) of intact and/or cleaved kininogen in a sample of the subject. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (kma), or other diseases mediated by pkal useful ...
Evaluation, assays and treatment of pkal-mediated disorders
Dyax Corp.
December 17, 2015 - N°20150362492

The invention provides assay methods of detecting plasma protease ci inhibitor (c1-inh) that binds plasma kallikrein, factor xii, or both, and uses thereof for identifying subjects at risk for or suffering from a pkal-mediated or bradykinin-mediated disorder. Provided methods permit analysis of patients with plasma kallikrein-mediated angioedema (kma), or other diseases mediated by pkal useful in the evaluation and ...
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