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|| List of recent Anergy-related patents
|Mucin antigen vaccine|
Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and cd40 ligand.
|Induction of tumor immunity by variants of folate binding protein|
The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic t-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness..
|Simultaneous inhibition of pd-l1/pd-l2|
Methods and compositions for treating an infection or disease that results from (1) failure to elicit rapid t cell mediated responses, (2) induction of t cell exhaustion, t cell anergy or both, or (3) failure to activate monocytes, macrophages, dendritic cells and/or other apcs, for example, as required to kill intracellular pathogens. The method and compositions solve the problem of undesired t cell inhibition by simultaneously inhibiting the pd-1 ligands, pd-l1 and pd-l2.
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Anergy topics: Immune Response, Expression Vector, Cancer Cells, Cancer Cell, Transcription, Polypeptide, Lymphocyte, Intracellular, Immune System, Macrophage, Dendritic Cell, Dissociation, Antagonist, Type I Diabetes, Rheumatoid Factor
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