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This page is updated frequently with new Anergy-related patent applications. Subscribe to the Anergy RSS feed to automatically get the update: related Anergy RSS feeds. RSS updates for this page: Anergy RSS RSS


Acellular pro-tolerogenic compositions for treatment/prevention of graft rejection

Canadian Blood Services

Acellular pro-tolerogenic compositions for treatment/prevention of graft rejection

Piezoelectric energy harvester device with a stopper structure, system, and methods of use and making

Microgen Systems

Piezoelectric energy harvester device with a stopper structure, system, and methods of use and making

Piezoelectric energy harvester device with a stopper structure, system, and methods of use and making

Hanergy Hi-tech Power (hk) Limited

Apparatus and methods for manufacturing thin-film solar cells


Date/App# patent app List of recent Anergy-related patents
07/30/15
20150209387 
 Method for inducing immune tolerance using non-proliferative polymer-modified allogeneic leukocytes patent thumbnailnew patent Method for inducing immune tolerance using non-proliferative polymer-modified allogeneic leukocytes
This invention relates to cellular-based therapies for increasing the level of regulatory t cells (treg) and/or decreasing the level of pro-inflammatory t cells (th17) to induce anergy or immune tolerance. To provide these therapeutic effects, a non-proliferative allogeneic leukocyte population is contacted with another leukocyte population.
Canadian Blood Services


07/16/15
20150196597 
 Acellular pro-tolerogenic compositions for treatment/prevention of graft rejection patent thumbnailAcellular pro-tolerogenic compositions for treatment/prevention of graft rejection
This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory t cells (treg) and/or decreasing the level of pro-inflammatory t cells (th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of mirnas and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer.
Canadian Blood Services


07/02/15
20150188458 
 Piezoelectric energy harvester device with a stopper structure, system, and methods of use and making patent thumbnailPiezoelectric energy harvester device with a stopper structure, system, and methods of use and making
The present invention relates to an energy harvester device comprising an elongate resonator beam comprising a piezoelectric material, the resonator beam extending between first and second ends; a base connected to the resonator beam at the first end with the second end being freely extending from the base as a cantilever; a mass attached to the second end of the resonator beam; a package surrounding at least a portion of the second end of the resonator beam; and a stopper connected to the mass and/or the second end of the resonator beam, where the stopper is configured to prevent contact between the second end of the resonator beam and the package. Also disclosed is a system, a method of powering an electrically powered apparatus, and methods of producing an anergy harvester device..
Microgen Systems, Inc.


07/02/15
20150184279 
 Apparatus and methods for manufacturing thin-film solar cells patent thumbnailApparatus and methods for manufacturing thin-film solar cells
Improved methods and apparatus for forming thin-film layers of semiconductor material absorber layers on a substrate web. According to the present teachings, a semiconductor layer may be formed in a multi-zone process whereby various layers are deposited sequentially onto a moving substrate web..
Hanergy Hi-tech Power (hk) Limited


06/25/15
20150175658 
 Induction of tumor immunity by variants of folate binding protein patent thumbnailInduction of tumor immunity by variants of folate binding protein
The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic t-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness..
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.


06/25/15
20150174168 
 Acellular pro-tolerogenic compositions and process for making same patent thumbnailAcellular pro-tolerogenic compositions and process for making same
This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory t cells (treg) and/or decreasing the level of pro-inflammatory t cells (th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of mirnas and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer.
Canadian Blood Services


06/18/15
20150164948 
 Acellular pro-tolerogenic compositions for the treatment/prevention of auto-immune diseases patent thumbnailAcellular pro-tolerogenic compositions for the treatment/prevention of auto-immune diseases
This invention relates to pro-tolerogenic preparations capable of increasing the level of regulatory t cells (treg) and/or decreasing the level of pro-inflammatory t cells (th17) to induce anergy or immune tolerance. The pro-tolerogenic preparation is enriched in at least one species of mirnas and is obtained by contacting two allogeneic leukocyte populations wherein at least one of the two populations is modified with a low-immunogenic biocompatible polymer.
Canadian Blood Services


10/30/14
20140322301 
 Mucin antigen vaccine patent thumbnailMucin antigen vaccine
Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and cd40 ligand.

08/14/14
20140227262 
 Pd-1 antagonists and methods for treating infectious disease patent thumbnailPd-1 antagonists and methods for treating infectious disease
Methods and compositions for treating an infection or disease that results from (1) failure to elicit rapid t cell mediated responses, (2) induction of t cell exhaustion, t cell anergy or both, or (3) failure to activate monocytes, macrophages, dendritic cells and/or other apcs, for example, as required to kill intracellular pathogens. The method and compositions solve the problem of undesired t cell inhibition by binding to and blocking pd-1 to prevent or reduce inhibitory signal transduction, or by binding to ligands of pd-1 such as pd-l1, thereby preventing (in whole or in part) the ligand from binding to pd-1 to deliver an inhibitory signal.

03/13/14
20140073045 
 Mucin antigen vaccine patent thumbnailMucin antigen vaccine
Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and cd40 ligand.

01/16/14
20140017218 

Method for inducing immune tolerance using viable polymer-modified allogeneic leukocytes


This invention relates to cellular-based therapies for increasing the level of regulatory t cells (treg) and/or decreasing the level of pro-inflammatory t cells (th17) to induce anergy or immune tolerance. To provide these therapeutic effects, two allogeneic leukocyte populations are contacted (in vivo, in vitro or ex vivo) and one of these leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition.

12/12/13
20130330294 

Serum amyloid a (saa) overrides regulatory t cells (treg) anergy


Methods and compositions are provided for inducing the proliferation of regulatory t cells. These methods find a number of uses, including, for example, treating autoimmune and rheumatoid diseases.

04/25/13
20130101626 

Mucin antigen vaccine


Provided are expression vectors for generating an immune response to a mucin. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal, a mucin antigen and cd40 ligand.

02/14/13
20130039935 

Induction of tumor immunity by variants of folate binding protein


The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic t-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness..

01/17/13
20130017199 

Simultaneous inhibition of pd-l1/pd-l2


Methods and compositions for treating an infection or disease that results from (1) failure to elicit rapid t cell mediated responses, (2) induction of t cell exhaustion, t cell anergy or both, or (3) failure to activate monocytes, macrophages, dendritic cells and/or other apcs, for example, as required to kill intracellular pathogens. The method and compositions solve the problem of undesired t cell inhibition by simultaneously inhibiting the pd-1 ligands, pd-l1 and pd-l2.



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Anergy topics: Immune Response, Expression Vector, Cancer Cells, Cancer Cell, Transcription, Polypeptide, Lymphocyte, Intracellular, Immune System, Macrophage, Dendritic Cell, Dissociation, Antagonist, Type I Diabetes, Rheumatoid Factor

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