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 Timepiece movement including an analogue display drive device patent thumbnailTimepiece movement including an analogue display drive device
Timepiece movement including a date display drive device formed of a display disc including a toothing, said drive device including driving means and a drive source. The driving means includes a wheel set including pins, having a toothed wheel and a pinion including pins, and an engaging wheel engaging said toothed wheel.
Eta Sa Manufacture Horlogere Suisse


 Apparatus for use in disturbance evaluation systems based on disturbance extraction from an electrical network patent thumbnailApparatus for use in disturbance evaluation systems based on disturbance extraction from an electrical network
Apparatus (1) for use in disturbance evaluation systems based on disturbance extraction, which apparatus (1) comprises measuring means for obtaining signal frequency both before (4) and after a disturbance (3) in an electricity network but excluding use of the disturbance transient itself, and interpolation means (5) for interpolating frequency across the disturbance interval to reflect the underlying frequency trend (9) uninfluenced by the disturbance transient. The apparatus (1) may include: (i) at least one delay means (2) for receiving at least one analogue or digital signal (6) from the electricity network; (ii) at least one first access point (p) at a first part of the delay means (2); (iii) at least one second access point (q) at a second part of the delay means (2), and the apparatus (1) being such that: (iv) the measuring means comprises: (a) a first frequency derivation means (3) for processing a set of access point outputs from the first access point and providing at least one measure of frequency (7) after the disturbance; and (b) a second frequency derivation means (4) for processing a set of access point outputs from the second access point or a delayed output means, for providing at least one measure of frequency (8) before the disturbance; and the interpolation means (5) receives the measure of frequency (7) after the disturbance and the measure of frequency (8) before the disturbance, and provides a measure of frequency (9) as a function of time over a period of interest, which comprises the disturbance interval and either side of the disturbance interval..
Outram Research Ltd


 Amylin analogues patent thumbnailAmylin analogues
The present invention relates to amylin analogues and to their use in the treatment or prevention of a variety of diseases, conditions or disorders, including obesity, excess food intake and associated metabolic diseases such as diabetes. The analogues have good physical and chemical stability, good solubility, and a long duration of action, and are well suited for use in the form of a liquid formulation..
Boehringer Ingelheim International Gmbh


 Novel amylin and calcitonin receptor agonist patent thumbnailNovel amylin and calcitonin receptor agonist
The present invention relates to peptides comprising an amino acid sequence seq id no: 1 (easelstaalgrlsaelhelatlprtetgpesp), analogues and derivatives thereof and pharmaceutical compositions comprising such peptides and derivatives. This invention further regards the use of these peptides according to seq id no: 1, analogues and derivatives thereof as medicaments..
Novo Nordisk A/s


 Acylated glucagon analogues patent thumbnailAcylated glucagon analogues
The present invention relates to novel peptide compounds which have an improved physical stability in solution and improved solubility at neutral ph, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity..
Novo Nordisk A/s


 Conjugates of somatostatin analogues patent thumbnailConjugates of somatostatin analogues
Conjugates of carriers and hydrogels for controlling the biological half-life of somatostatin and its analogs are disclosed.. .
Prolynx Llc


 Pharmaceutical composition patent thumbnailPharmaceutical composition
The present invention discloses a composition comprising readily dissociable molecular aggregates formed by combining an insulin, insulin analogue, derivative or metabolite having isoelectric point between 5.8 to 8.5 in combination with one or more an insulin, insulin analogue, derivative or metabolite having isoelectric point between 4.0 to 5.7.. .
Wockhardt Limited


 Inhibitors of long and very long chain fatty acid metabolism as broad spectrum anti-virals patent thumbnailInhibitors of long and very long chain fatty acid metabolism as broad spectrum anti-virals
The present invention provides methods and compounds for treating viral infections using modulators of host cell enzymes relating to long chain fatty acid and lipid droplet metabolism. It includes a method of treating viral infections using triacsin c and its relatives, analogues and derivatives as well as other inhibitors of long chain fatty acid metabolism and lipid droplet metabolism..
The Trustees Of Princeton University


 Header position sensing system for an agricultural harvester patent thumbnailHeader position sensing system for an agricultural harvester
There is provided a system and method for determining the relative position of a header with respect to a chassis of a self-propelled agricultural harvester. Single or dual axis inclinometers are secured with respect to the header and the chassis respectively and signals generated thereby in combination with a stored relationship to header position are used to determine the header position, whether that be the pitch and/or the roll degrees of freedom.
Agco Corporation


 Pre-compensation of the phase shifting error patent thumbnailPre-compensation of the phase shifting error
In this disclosure, methods for pre-compensation of the phase shifting error, and apparatuses for the same are disclosed. In one example, a device performs precoding of a digital signal, while acquiring information on an error caused by a phase shifting of the precoding.
Lg Electronics Inc.


Method and processing a recording


A method and apparatus for processing a recording is described. analogue audio data is recorded and converted into digital audio data.
Tencent Technology (shenzhen) Company Limited


Movement stage for a hydraulic shock absorber and shock absorber with the movement stage


A movement stage for a hydraulic shock absorber has a damping volume and a stage throttle with a valve disk, an analogue piston, and an elastic biasing means supported on the analogue piston and on the valve disk. The valve disk has a pressure surface defining a portion of the surface of a disk valve arranged upstream of an entry edge of a disk valve seat.

Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods


This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue.. .
The Trustees Of Columbia University In The City Of New York


Inhibitors of complement activation


The invention relates to factor d inhibitors, which bind to factor d and block the functional activity of factor d in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like fab, f(ab′)2 and fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds.
Genentech, Inc.


Production of human pulmonary surfactant protein b in plants


The invention is directed to a method of producing pulmonary surfactant protein-b (sp-b) isoforms fragments and analogues thereof in a plant cell, and to expression cassettes for expression of the sp-b proteins in plants. The expression cassettes may include various elements for improved expression, stability of the expressed protein or efficient purification of the expressed protein, including signal sequences, protease cleavage sites for release of the target protein, trafficking peptides for trafficking of the expressed protein to various plant compartments, and/or various tags..
Azargen Biotechnologies (pty) Ltd


Novel scorpion toxin analogue and treating autoimmune diseases


A novel peptide analogue of the heterometrus spinnifer toxin hstx1 is disclosed along with its application as, for example, a therapeutic agent for treating an autoimmune disease such as multiple sclerosis (ms) or rheumatoid arthritis (ra). The analogue comprises a peptide with an amino acid substitution at amino acid position 14 of the wild-type (wt) peptide sequence (or a position corresponding to position 14 of the wt peptide sequence).
Baylor College Of Medicine


Massive parallel decoding dna and rna


This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of dna in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —oh group at the 3′-position of the deoxyribose..
The Trustees Of Columbia University In The City Of New York


Substituted isoindoline-1,3-dione derivatives


This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast.
Concert Pharmaceuticals, Inc.


Securinine and norsecurinine analogue compounds for the treatment of myeloid disorders


The present application relates to securinine or norsecurinine analogues that, when administered to immature myeloid cells, promote differentiation of these cells to mature cells that do not readily proliferate. Therefore, the agents are useful in the treatment of myeloid disorders including myeloproliferative disorders, acute myeloid leukemia, and autoimmune diseases.
Case Western Reserve University


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Monitoring device and surge arrester system


A device for monitoring a surge arrester, including: a grounding line; a measuring unit including one or more analogue measuring circuits for measuring the electric current passing through the grounding line; an electronic processing unit for receiving measuring signals from the measuring circuits; a data storage medium for storing monitoring data produced by the processing unit; a base module, which accommodates the grounding line and the measuring unit; and an auxiliary module, which accommodates the processing unit and the data storage medium and is detachably mountable to the base module. When the auxiliary module is mounted to the base module, the components of the modules are connected to each other through a connector member provided on the base module and a corresponding connector member provided on the auxiliary module..
Abb Technology Ltd


Method for determining the timing of the receipt of a radio message


Method for determining the time of receipt by a radio receiver (320,330,340) of a binary coded radio message emitted by a sender (310), whereby the radio signal is received by the receiver so that an analogue electrical signal is achieved, which analogue signal is sampled and optionally demodulated, whereby the data content of the message is determined based upon the demodulated signal as a stream of data bits, which stream of data bits comprises a predetermined signal element whose time of receipt is determined. The invention is characterised in that a digitally stored, constructed comparison signal is created based upon the said stream of data bits, so that the constructed comparison signal is constructed to correspond to the sampled signal, in that a time variable which maximizes a correlation between the constructed comparison signal and the sampled signal is determined, and in that the time variable is then used to correct the said time determination of the receipt of the predetermined signal element..
True Heading Ab


Electromigration testing of interconnect analogues having bottom-connected sensory pins


A system for electromigration testing is disclosed. The system includes a conductive member, a cap layer of insulative material over at least a portion of a top surface of the conductive member, a cathode conductively connected to a first end of the conductive member; an anode conductively connected to a second end of the conductive member, and a current source conductively connected to the cathode and the anode.
Globalfoundries Inc.


Analogue measurement data detection system and battery voltage detection system


An analogue measurement data detection system according to the present invention includes: a reference voltage generation circuit configured to generate and output a reference voltage; an analogue/digital converter configured to compare an analogue signal with die reference voltage outputted from the reference voltage generation circuit, and based on a differential voltage between the analogue signal and the reference voltage, generate and output a digital signal corresponding to the analogue signal. The reference voltage generation circuit is configured to cause the reference voltage to have such a temperature characteristic as to compensate for temperature characteristics of at least the analogue/digital converter and the reference voltage generation circuit..
Panasonic Intellectual Property Management Co., Ltd.


Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof


The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.. .
University Of Maryland, Baltimore County


Mini-gastrin analogue, in particular for use in cck2 receptor positive tumour diagnosis and/or treatment


A gastrin analogue shows high uptake in cck-2 receptor positive tumors and simultaneously a very low accumulation in the kidneys. This is achieved by a mini-gastrin analogue pp-f11 having the formula: pp-f11-x-dglu-dglu-dglu-dglu-dglu-dglu-ala-tyr-gly-trp-y-asp-phe-nh2, wherein y is an amino acid replacing methionine and x is a chemical group attached to the peptide for diagnostic and/or therapeutic intervention at cck-2 receptor relevant diseases.
Paul Scherrer Institut


Ramp-type analogue-digital conversion, with multiple conversions or single conversion, depending on the light level received by a pixel


In a matrix image sensor, a method of reading a pixel of a column allows two modes of analogue-digital conversion of the voltage level provided by the column: a first mode in which are carried out a single analogue-digital conversion in a nominal conversion time window fconv, of nominal duration dn and a counting which starts with a ramp of nominal duration dn and stops upon the toggling of the output scmp of the comparator; and a second mode which provides for multiple conversions by comparison with a ramp of reduced duration dr, in the same nominal conversion time window. The selection of the mode of conversion to be applied is based on the observation of the state of the output scmp of the comparator after a predetermined duration after the instant ti of ramp start: if the output has toggled, the useful level to be converted represents a low light level to which the second mode with multiple conversions will be applied; if the output has not toggled, the useful level to be converted represents a high light level and the first, conventional, mode with single conversion will be applied.
E2v Semiconductors


Methods for treating restenosis using annexin a5


A method for the prophylaxis or treatment of restenosis comprising administering a therapeutically effective amount of annexin a5 or a functional analogue or variant thereof to a patient in need of such treatment. A method for the treatment of stenosis in a patient comprising performing an intervention for the treatment of stenosis in conjunction with administering a therapeutically effective amount of annexin a5 or a functional analogue or variant thereof.
Annexin Pharmaceuticals Ab


Drug for preventing and/or treating polycystic kidney disease


The present invention provides a combined drug for an injectable depot formulation having a superior effect of preventing and/or treating polycystic kidney disease. More specifically, the present invention relates to a drug for preventing and/or treating polycystic kidney disease, which is an injectable depot formulation comprising a particle containing tolvaptan or a prodrug thereof and a somatostatin analogue.
Otsuka Pharmaceutical Co., Ltd.


Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs


Embodiments of the present invention provide a method for treatment of respiratory disorders such as asthma, chronic obstructive pulmonary disease, and chronic sinusitis, including cystic fibrosis, interstitial fibrosis, chronic bronchitis, emphysema, bronchopulmonary dysplasia and neoplasia. The method involves administration, preferably oral, nasal or pulmonary administration, of anti-inflammatory and anti-proliferative drugs (rapamycin or paclitaxel and their analogues)..
Lutonix, Inc.


N-methyl pyrazoloanthrone for treatment of cancer


The present invention relates to a n1-methyl-pyrazoloanthrone, e.g., a n1-methyl 1,9-pyrazoloanthrone or functional derivatives or analogues thereof to inhibit at least one kinase of the ck1 family (e.g., csnk1a1, csnk1b, csnk1g1, csnk1g2, csnk1g3, csnk1d, csnk1e) and/or ark5/nuak1 in a cell. Another aspect relates to administration of n1-methyl-pyrazoloanthrone, e.g., a n1-methyl 1,9-pyrazoloanthrone or a functional derivative thereof in a method to treat cancer, e.g., a cancer with increased expression and/or a genetic alteration in at least one member of the ck1 family and/or ark5/nuak.
The General Hospital Corporation


Mitigating a phase anomaly in an analogue-to-digital converter output signal


A method and apparatus for mitigating a phase anomaly in an analogue-to-digital converter (adc) output signal is disclosed. A plurality of codewords output by the adc are received and information about an estimated level of interference between an output of the adc and an input of the adc due to the codeword is obtained for each codeword based on the logic values of bits in the codeword.
Airbus Defence & Space Limited


Connectors for audio data transfer


This application relates to methods and apparatus for transfer of data between a host device (400) and a peripheral device (300) via a usb type-c connector (100; 304) of the host device. A data controller is described that has a path controller (309, 310; 706) for establishing signal paths between circuitry of the host device and contacts (101) of said usb type-c connector.
Cirrus Logic International Semiconductor Ltd.


Electronic measurement circuit


The electronic measurement circuit comprises a measurement sensor with two differential mounted capacitors each comprising a fixed electrode, and a common electrode arranged to move relative to the fixed capacitor electrode to alter the capacitive value when the physical parameter is measured. The circuit further comprises a first integrator unit connected to the common electrode for integrating charge received from the sensor, and comprising two integrators arranged to be connected alternately to the common electrode, a first comparator for comparing analogue output values from the first integrator unit, a second integrator unit for integrating charge received from the first integrator unit, a second comparator for comparing analogue output values from the second integrator unit, a switch circuit for switching different voltage values across the capacitors, and a feedback circuit for feeding a digital output signal from the first comparator to the switch circuit for controlling its operation, and an incremental calculation unit receiving digital output signals from the comparators and supplying a final digital output signal..
Em Microelectronic Marin S.a.


Anti-viral pyrimidine nucleoside analogues


A compound of formula (i) wherein ar can be one six-membered or two fused six-membered aromatic rings; r8 and r9 can be hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, or aryl; q can be o, s or cy2, where y may be h, alkyl or halogens; x can be o, nh, s, n-alkyl, (chr2)m where m is 1 to 10, and cy2; z can be o, s, nh, or n-alkyl; u″ is h and u′ can be h or ch2; wherein: t can be oh, h, halogens, o-alkyl, o-acyl, o-aryl, cn, nh2 or n3; t′ and t″ can be h or halogen; and w can be h or a phosphate group. Compounds show anti-viral activity, for example with respect to varicella zoster virus..
University College Cardiff Consultants Limited


Method of producing beraprost


An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds..
Lung Biotechnology Pbc


New pradimicin derivatives for the treatment of diseases caused by kinetoplastids


The present invention relates to a class of novel pradimicins and analogues and derivatives thereof, including the compounds of formula a, i and 111, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof and their use to treat or prevent kinetoplastid infections and their use to manufacture a medicine to treat or prevent kinetoplastid infections, particularly infections with trypanosoma and leishmania, such as trypanosoma brucei, trypanosoma cruzi and leischmania donovani. Wherein ra, r1, r2, r3, r4, r5, r6, r7, r8 and r9 are as defined in the claim 1 or as described in detail in the description of the invention.
Consejo Superior De Investigaciones CientÍficas - Csic


Tacrolimus for improved treatment of transplant patients


An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time.
Veloxis Pharmaceuticals A/s


Controlled release pharmaceutical formulations of nitazoxanide


Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation.
Romark Laboratories L.c.


Compositions and methods for using esters of meroterpenes and of other resveratrol analogues


The invention includes compositions and methods of using meroterpene esters for effectively modulating skin cell function and remediating undesirable skin conditions, as well as the use of such compositions in the treatment of systemic diseases, such as cancer and in nutritional, dermatologic and cosmetic applications, through topical and transbuccal delivery as well as by ingestion, injection or inhalation.. .

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Mono disperse polymer nanoparticles, functionalized nanoparticles and controlled formation method


A method produces polymer nanoparticles. Polymer solution is sprayed through a nozzle toward a collector.
The Curators Of The University Of Missouri


Apparatus and transmitting and receiving beam information in wireless communication system


The present disclosure relates to transmitting and receiving beam information in a wireless communication system. An operation of a receiving end includes: generating a signal indicating two or more analogue transmission beams which are allocable to the receiving end; and transmitting the signal.
Samsung Electronics Co, Ltd.


Peptide oligonucleotide conjugates


Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..
Sarepta Therapeutics, Inc.


Stable aqueous parenteral pharmaceutical compositions of insulinotropic peptides


Disclosed herein is an insulinotropic peptide multi-dose aqueous parenteral pharmaceutical composition and use thereof. A long-term storage formulation of the insulinotropic peptide can be obtained via the method of the present disclosure.
Shanghai Benemae Pharmaceutical Corporation


Methods of inducing melanogenesis in a subject


Described herein are methods and compositions for inducing melanogenesis in a human subject. The method comprises administering to a subject an alpha-msh analogue, in an effective amount and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without inducing homologous desensitization of the melanocortin-1 receptors..
Clinuvel Pharmaceuticals Limited


Compounds and methods for the treatment of vascular disease


The present invention relates to a method for the treatment of vascular dysfunction, reducing ischemic pain and/or treatment of a vascular disease comprising administering a therapeutically effective amount of annexin a5 or a functional analogue or variant thereof to a patient in need of such treatment. The vascular dysfunction, ischemic pain and/or vascular disease may be associated with impaired endothelium mediated vasodilatation, a reduced enos activity, and/or a reduced no bioavailability.
Annexin Pharmaceuticals Ab


Meat texturizer


A food product comprising a co-processed mixture, which mixture comprises at least one plant protein-containing composition and at least one rice carbohydrate-containing composition, which is particularly useful as a meat extender or a meat analogue, products containing said food products and processes for obtaining them.. .
Sudzucker Aktiengesellschaft Mannheim/ochsenfurt


Frozen dessert mixes using soy protein products


A soy protein product having a protein content of at least about 60 wt% (n×6.25) d.b., preferably at least about 90 wt %, and being completely soluble at ph values of less than about 4.4 and heat stable at such ph values is used to provide, at least in part, the protein component of a dairy analogue or plant/dairy blend frozen dessert mix.. .
Burcon Nutrascience (mb) Corp.


Process for the preparation of voriconazole and analogues thereof


The present invention provides a process for preparing a compound of formula: (formula xi and xii) (xi) (xii) wherein x, y, z, a, b and e are as defined herein, by reacting a compound of formula: (formula xiii) (xiii) with a compound of formula: (formula xiv and xv) (xiv) (xv) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates..
Pfizer Ireland Pharmaceuticals


A process for the preparation of anti-inflammatory aroylbenzofuran compounds


Disclosed herein an efficient process for synthesis of benzofuran analogues having anti-inflammatory activity which comprises, ru-catalyzed branched and linear selective alkylation of aroylbenzofurans formula-i with alpha, beta unsaturated esters of formula-ii via c—h activation in presence of base, additives and organic solvent at suitable temperature to give high yield of desired linear alkylated benzofuran compounds of formula-iii or branched alkylated benzofuran compounds of formula-iv or mixture thereof.. .
Council Of Scientific And Industrial Research


Therapeutic compositions including phenazine-3-one and phenothiazine-3-one derivatives and uses thereof


Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of phenazine-3-one and/or phenothiazine-3-one derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to phenazine-3-one or phenothiazine-3-one derivatives and uses of the same.
Stealth Biotherapeutics Corp


Prostaglandin f2alpha and analogues thereof for treating atrophic cutaneous scarring


A method of treating atrophic cutaneous scarring in humans is claimed. The method involves the topical application of a therapeutic amount of prostaglandin f2-alpha (pgf 2α) or a pgf 2α analog directly to the area of atrophic scarring..
Galderma S.a.


Hypertension reducing composition


A composition effective to relax smooth muscles in an individual in an altered state is described. The composition includes a dosage of gaba or gaba-a analogue, and a dosage of at least one of an ace inhibitor and an arb combined with the dosage of gaba or gaba-a analogue into a deliverable form..

Composition containing attractant of noxious arthropod comprising plant-derived component and analogue of same


This invention provides a composition with method of controlling and attracting noxious arthropods, and protecting plants from damage caused by noxious arthropods. The invention provides a noxious arthropod attractant composition that shows synergistic effects and comprises at least two types of compounds selected from the group consisting of p-anisaldehyde, benzaldehyde, ethyl nicotinate, geraniol, linalool, nerol, citronellol, o-anisaldehyde, β-farnesene, methyl anthranilate, methyl benzoate, o-aminoacetophenone, o-anisidine, methyl m-aminobenzoate, methyl o-toluate, eugenol, 3-phenylpropylaldehyde, cinnamaldehyde, eucalyptol, squalene and α-hexylcinnamaldehyde..
Kyoyu Agri Co., Ltd.


Hepcidin analogues and uses thereof


The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.. .
Portagonist Therapeutics, Inc.


Uridine and uridine analogues for treatment of specific lung diseases, namely copd and pulmonary fibrosis


The present invention relates to the new indications of chronic obstructive pulmonary disease (copd) and idiophathic lung fibrosis (ipf) for uridine and uridine analogues.. .
Universitaetsklinikum Freiburg


Antibiotic compounds that inhibit bacterial protein synthesis


An aminoacylation/translation (ait) system based on the protein synthesis system from the pathogen pseudomonas aeruginosa, was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: ef-tu, ef-ts and ef-g, aminoacyl trna synthetase (aars) specific for phenylalanine, phers, and ribosomes isolated from cultures of pseudomonas aeruginosa.
The Board Of Regents Of The University Of Texas System


Built in self-test


A method for testing a dac comprising controlling the dac digitally to cause it to produce a known desired analogue output, for example a fixed amplitude sine wave; determining the duration of fixed voltage segments of the actual output of the dac and using the duration of the fixed voltage segments to assess or determine performance of the dac.. .
Ateeda Limited


Apparatus for detecting noise in power supply of plc analogue input and output module


An apparatus for detecting noise in a power supply of a plc analog input/output module is provided. The apparatus may include a capacitor configured to extract a noise determination target voltage from a driving voltage outputted from the power supply; a voltage conversion unit configured to convert the noise determination target voltage outputted from the capacitor and to output the converted noise determination target voltage; a comparison unit configured to compare the noise determination target voltage converted by the voltage conversion unit with a reference voltage; and a determination unit configured to determine whether the noise determination target voltage is a noise, based on a comparison result by the comparison unit..
Lsis Co., Ltd.


Novel derivative of an insulin analogue


The present invention provides a novel derivative of an analogue of human insulin, useful for the treatment of diabetes.. .
Novo Nordisk A/s


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Stabilized polypeptide insulin receptor modulators


Provided herein are stabilized α-ct polypeptides comprising an alpha-helical segment, and wherein the polypeptide is of formula (i-1) or formula (i-2): rf—[xaa]s—xa1—xa2—xa3—xa4—xa5—xa6—xa7—xa8—xa9—xa10—xa11—xa12—xa13—xa14—[xaa]t—re (i-1) rf—[xaa]s—xc1—xc2—xc3—xc4—xc5—xc6—xc7—xc8—xc9—xc10—xc11—xc12—xc13—xc14—xc15—xc16—xc17—xc18—xc19—xc20—[xaa]t—re (i-2) wherein the α-ct polypeptide binds to the insulin receptor, and wherein the α-ct polypeptide includes at least one staple (i.e. Two cross-linked amino acids) and/or at least one stitch (i.e.
President And Fellows Of Harvard College


Compositions for reducing hair loss and/or increasing hair regrowth


The invention relates to a composition comprising 2% to 5% minoxidil, 0.01% to 15% finasteride and 0.01% to 15% of a prostaglandin analogue. In one embodiment, the prostaglandin analogue is latanoprost.
Triple Hair, Inc.


Use of sarmentine and its analogues with an herbicide, and compositions thereof


Disclosed herein are methods for modulating (e.g., inhibiting) emergence and growth of monocotyledonous or dicotyledonous plants (e.g., weeds and grasses) using sarmentine and/or a sarmentine analogue and a second herbicide. The application of sarmentine and/or a sarmentine analogue with a second herbicide to a plant and/or its growth substrate results in a synergistic pre- and/or post-emergence herbicidal activity against the plant.
Marrone Bio Innovations, Inc.


Arrangement, system and methods therein for monitoring a transmission line


A method in an arrangement for monitoring a transmission line to a radio device in a communication network, wherein the transmission line comprises an optical part carrying signals in an optical domain and an electrical part carrying analogue information signals in an electrical domain. The arrangement selects a carrier in the electrical part for monitoring the transmission line by assigning a test signal to a subcarrier out of a number of subcarriers of an optical carrier, wherein the subcarrier in the optical domain corresponds to the selected carrier in the electrical domain.
Telefonaktiebolaget L M Ericsson (publ)


Method for transmitting and receiving sound waves using time-varying frequency-based symbol, and apparatus using the same


A method for transmitting sound waves using a time-varying frequency-based symbol includes the steps of: storing waveform data in a digital form; converting the waveform data in the digital form into an analogue signal; and outputting the analogue signal as sound waves through a speaker. Herein, the waveform data in the digital form includes a symbol the frequency of which changes with time within a sound wave band..
Soundlly Inc.


System and transmitting sensor data from a rotating component of a turbomachine


A system for transmitting data from a rotating component of a turbomachine includes a plurality of thermal sensors coupled to corresponding rotatable components within the turbomachine where each thermal sensor generates a discrete analogue signal indicative of temperature. A plurality of transmitter assemblies is coupled to an end of a rotor shaft of the turbomachine.
General Electric Company


Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein


Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b) a prototrophy-restoring enzyme in a host cell that is auxotrophic for at least one metabolite. In various embodiments, the host cell is auxotrophic for a nitrogenous base compound or an amino acid.

Cyclosporine analogue molecules modified at amino acid 1 and 3


Analogues of cyclosporin-a are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-a, and reduced immunosuppressivity in comparison with cyclosporin-a and analogs thereof modified solely at position 1..
Ciclofilin Pharmaceuticals Corp.


Phosphohistidine and phosphotyrosine analogues


The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating said antibodies.
University Of Sheffield


Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue


The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hghrelin.. .
Ipsen Pharma S.a.s.


Treatment and prevention of autism and autism spectrum disorders


In some embodiments, the present invention provides certain compositions and methods that may be useful in the treatment and/or prevention of a neurodevelopmental disorder, such as autism or an autism spectrum disorder (asd). In some such embodiments, compositions are provided that contain at least one fenamate active agent, such as mefenamic acid, or an analogue or derivative thereof.
The Rockefeller University


Light emitting device


A light emitting device includes at least one light emitting unit, a micro controller and a control module. The control module includes a storage unit configured to store a reference sheet between an intensity of the light emitting unit and a current value of the light emitting unit.
Hon Hai Precision Industry Co., Ltd.


Digital/analogue conversion apparatus


A digital/analog conversion apparatus to convert a digital signal into an analog signal. The digital/analog conversion apparatus can generate a high-quality analog signal, even when elements configuring the digital/analog conversion apparatus have variance, with high resolution and a small circuit size.
Trigence Semiconductor, Inc.


Method of transmiting data and a device and system thereof


A method for transmitting a data signal from a sending-end 100 to a receiving-end 200 includes the steps of spreading the data signal into a spread spectrum signal, combining the spread signal with an analogue signal into a mixed signal. The mixed signal can be transmitted or broadcasted to the receiving-end 200.
Well Being Digital Limited


Bulk driven low swing driver


A circuit is presented to reduce power while transmitting high speed signals across a long length of wire on an integrated circuit. A pmos is used as a low swing driver, where the pmos is connected between the driver's output and ground.
Sandisk Technologies Inc.


Glp-1 derivatives, and uses thereof


The present invention relates to tri-acylated glp-1 derivatives, acylated at positions corresponding to positions (18, 22, 30), (18, 26, 37), (18, 27, 37), (26, 30, 37), or (27, 30, 37) of the native human glucagon-like peptide 1 (glp-1 (7-37) (seq id no: 1); or pharmaceutically acceptable salts, amides, or esters thereof. The acylated side chains comprise a protracting moiety selected from chem.
Novo Nordisk A/s


Radiosensitivity of fluorophores and use of radioprotective agents for dual-modality imaging


The present application discloses compositions and methods of use of dual-labeled molecules comprising a fluorescent probe and a radionuclide. The labeled molecules are of use for detection, imaging and/or diagnosis of diseased tissues, such as tumors.
Immunomedics, Inc.


Compounds compositions and methods including thermally labile moieties


The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods of making the compounds and compositions and methods of using the compounds and compositions. In one aspect, the present invention is directed to a compound of the structure xo—ch2—sm-b-a.
Biosearch Technologies, Inc.


Therapeutic compositions including iron chelators and uses thereof


Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of at least one iron chelator, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to at least one iron chelator and uses of the same.

Pyrazoloanthrone and derivatives thereof for treatment of cancers expressing missrii


The present invention relates to pyrazoloanthrones or functional derivatives or functional analogues thereof to activate mis receptor-mediated downstream effects in a cell. In particular, the present invention relates to method to prevent and treat cancer that expresses mis receptor type ii (misrii) by administering to a subject at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof.
The General Hospital Corporation


Radio repeater system


A system and/or method for facilitating wireless communication in an area where it is difficult to transmit and receive signals may use a preexisting wired emergency communication infrastructure to transmit signals between elements of a radio repeater system. Optionally, the system may include synchronization of retransmissions.

Liposomal curcumin for treatment of cancer


The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system.
Board Of Regents, The University Of Texas System


Feline scratch marking semiochemicals


Semiochemical compositions comprising a feline scratch marking semiochemical analogues of these semiochemical compositions and a method to prevent cats from scratching in particular places and on multiple objects are described.. .
Institut De Recherche En Semiochimie Et Ethologie Appliquee


Measuring transducer for converting an analogue electrical input signal into an analog electrical output signal


A measuring transducer for converting an analog electrical input signal into an analog electrical output signal. The measuring transducer contains a detection apparatus which is designed to detect an analog electrical input signal within a predetermined input measurement range, wherein the input measurement range of the measuring transducer is divided into n adjustable partial input measurement ranges and the output range of the measuring transducer is divided into n adjustable partial output ranges, where n is greater than 1.

Codon-optimized gene for mutated shrimp luciferase and use thereof


There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.

Cortistatin analogues for the treatment of inflammatory and/or immune diseases


The invention relates to cortistatin analogues and their uses. The compounds of the invention are peptide ligands with potential application in the diagnosis, prevention or therapy of those pathologies where receptors capable of binding to cortistatin, specific or shared with other molecules such as somatostatin and/or ghrelin (ghsr), are expressed, being in addition more stable in serum than cortistatin..

Novel indazole compounds and a process for the preparation thereof


The patent discloses novel indazole compounds of general formula 1 and analogues thereof, use thereof for the treatment of diabetes, diabetic complications, cardiovascular dysfuntion or related diseases, pharmaceutical compositions comprising them and processes for their preparation.. .

Aqueous sustained release compositions of lhrh analogues


An aqueous pharmaceutical composition for the sustained release of an lhrh analogue, in particular for a sustained release compatible with therapeutic treatments for at least 2 weeks. The pharmaceutical compositions are particularly useful for the treatment of diseases an lhrh analogue is indicated for..

Heterocyclyl pyrimidine analogues as tyk2 inhibitors


Wherein r, r1, x1 to x5 have the meaning as cited in the description and the claims. Said compounds are useful as tyk2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases.

Rodenticide


The present invention relates to rodenticides, methods of killing a rodent comprising administering to said rodent, a lethal dose of an isolated yersinia murine toxin polypeptide or an isolated antigenic analogue thereof, and methods of manufacturing novel rodenticides.. .

Functionalized carboranyl magnesium electrolyte for magnesium battery


Electrochemical devices and processes for forming them employ a functionalized carboranyl magnesium electrolyte. The functionalized carboranyl electrolyte includes a carboranyl anion functionalized with at least one halide, or one alkyl, aryl, alkoxy, and/or aryloxy groups, or their partially or completely fluorinated analogues.

Functionalized carboranyl magnesium electrolyte for magnesium battery


An electrochemical device is provided having a functionalized carboranyl magnesium electrolyte. Specifically the disclosure relates to an electrochemical device having a magnesium anode, a cathode, a current collector made of non-noble metal, and a functionalized carboranyl magnesium electrolyte.

Connection device


A connecting device comprises housing, a board with electrical components, including at least one digital bus connection and an input/output section. It allows outsourcing of analogue and digital i/o from a connected device, e.g.

Electromechanical apparatus comprising a capacitive device for detection of the angular position of a wheel set, and detection of the angular position of a wheel set


Electromechanical apparatus comprising a wheel set and an analogue indicator member (14) which are integral in rotation, a stepping motor, and a capacitive device for detection of the angular position of the wheel set, comprising a rotor (4: 10), a stator (18a, 18b, 20a, 20b, 22, 24, 26a, 26b, 26c) and an electronic measuring circuit (28), the stator comprising a first pair of electrodes (18a, 18b) having a first capacitance (c1) and a second pair of electrodes (20a, 20b) having a second capacitance (c2), the rotor being adapted such that the values of the two capacitances depend on the angular position of the rotor, and an electronic measuring circuit (28) being provided for generating an output signal representative of a difference between the respective values of the first (c1) and of the second (c2) capacitance.. .

Enzymatic transamination of cyclopamine analogs


Provided are processes for the synthesis of amino analogues from ketone starting materials.. .

Method for producing dopaminergic neurons


The present invention provides a method of more efficiently producing a high-quality dopaminergic neuron from neural progenitor cells, specifically, a production method of a dopaminergic neuron including a step of culturing neural progenitor cells in a medium containing (i) a camp analogue and (ii) a mek inhibitor. Moreover, the present invention also provides a medicament containing a dopaminergic neuron obtained by the method, and a reagent and a kit to be used for the method..

Modified peptides as potent inhibitors of the psd-95/nmda receptor interaction


The present invention is directed to the provision of small molecule inhibitors of the psd-95/nmda receptor interaction, employing an undecapeptide corresponding to the c-terminal of the nmda as a template for finding lead candidates. A compound (nmdar/psd-95 inhibitor) of the invention includes a peptide or peptide analogue comprising at least four peptide bonded residues having the sequence ytxv or ysxv, wherein y is selected from among e, q, and a, or an analogue thereof, and x is selected from among a, q, d, n, n-me-a, n-me-q, n-me-d, and n-me-n or an analogue thereof, wherein an amino-terminal residue of the peptide is n-alkylated.

Rapamycin analogues and their pharmaceutical use


Novel rapamycin analogues and methods for their production with fkbp and/or mip inhibitory activity with reduced mtor inhibitory activity with therapeutic potential e.g. As bacterial virulence inhibitors..

Amino acid derivatives


There are provided pyrrolysine analogues of the formulae (x), (i), (ii), (v), (vi), (vii) and (viii), in which the a, b, d, x, y, z, fg, r, r1, r2 and r3 are as defined in the claims, which are useful in bioconjugation processes and mutant proteins containing them.. .

Composition for the treatment of cystic fibrosis


The present invention provides compositions comprising a prostacyclin or prostacyclin analogue, or a pharmaceutically acceptable salt thereof for use in preventing or treating cystic fibrosis. The invention also provides the use of a kit comprising a prostacyclin or prostacyclin analogue for treating or preventing a condition associated with cystic fibrosis in a subject..



Analogue topics:
  • Carbon Dioxide
  • Amino Acid
  • Radio Signal
  • Inorganic Compounds
  • Hydrogen Production From Water
  • Electrolysis
  • Semiconductor
  • High Energy
  • Semiconductor Material
  • Transmitter
  • Synchronization
  • Concurrent
  • Surfactant
  • Hyperglycemia
  • Pharmaceutically Acceptable Salt


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