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This page is updated frequently with new Analogue-related patent applications. Subscribe to the Analogue RSS feed to automatically get the update: related Analogue RSS feeds. RSS updates for this page: Analogue RSS RSS


Selective gpcr ligands

Selective gpcr ligands

Date/App# patent app List of recent Analogue-related patents
10/09/14
20140303260
 Pharmaceutical compositions of resveratrol patent thumbnailPharmaceutical compositions of resveratrol
A pharmaceutical composition for administering a therapeutically effective amount of resveratrol or a functionally equivalent analogue or derivative thereof to a subject. The absorption of resveratrol occurs through the subject's buccal/sublingual membranes, thereby by-passing first pass metabolism by the liver..
10/09/14
20140303166
 Cosmetic method for changing the appearance of eyes patent thumbnailCosmetic method for changing the appearance of eyes
The current application is directed to cosmetic methods for changing the appearance of eyes by causing a retraction of the eyelids so that the eyes appear to be more open and have a wider appearance. Various methods involve application of one or more prostaglandins, synthetic prostaglandins, including synthetic prostaglandin f, and synthetic prostaglandin analogues, to eyelids, which results in contraction of eyelid muscles and a wider, more open appearance of the eyes..
10/09/14
20140303082
 Selective gpcr ligands patent thumbnailSelective gpcr ligands
In the past decade a great deal of structural information for class a-gpcrs (g protein-coupled receptors) has emerged. However, the structural and electronic basis of ligand selectivity for closely related receptor subtypes such as the angiotensin receptors at1ar and at2r, which present completely diverse biological functions in response to the same ligand, is poorly understood.
10/09/14
20140303076
 Non-standard insulin analogues patent thumbnailNon-standard insulin analogues
An insulin analogue comprises a b-chain polypeptide containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29. A proinsulin analogue or single-chain insulin analogue containing a b domain containing a cyclohexanylalanine substitution at position b24 and optionally containing additional amino-acid substitutions at positions a8, b28, and/or b29.
10/09/14
20140302553
 Biosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues patent thumbnailBiosynthetically generated pyrroline-carboxy-lysine and site specific protein modifications via chemical derivatization of pyrroline-carboxy-lysine and pyrrolysine residues
Disclosed herein is pyrroline-carboxy-lysine (pcl), a pyrrolysine analogue, which is a natural, biosynthetically generated amino acid, and methods for biosynthetically generating pcl. Also disclosed herein are proteins, polypeptides and peptides that have pcl incorporated therein and methods for incorporating pcl into such proteins, polypeptides and peptides.
10/02/14
20140296567
 3-hydroxyanthranilic acid (3-haa) therapy for prevention and treatment of hyperlipidemia  and its cardiovasular complications patent thumbnail3-hydroxyanthranilic acid (3-haa) therapy for prevention and treatment of hyperlipidemia and its cardiovasular complications
The present invention relates to the use of a tryptophan metabolite, 3-hydroxyanthranilic acid (3-haa) or a functional analogue thereof, for prophylactic and/or therapeutic treatment of mammals, in special humans, against hyperlipidemia and its cardiovascular complications, i.e. Atheroma formation, myocardial infarction and heart failure, ischemic stroke and transient ischemic attacks, renal impairment, aortic aneurysms and critical limb ischemia caused by atherosclerosis..
10/02/14
20140296307
 Potent analogues of the c-myc inhibitor 10074-g5 with improved cell permeability patent thumbnailPotent analogues of the c-myc inhibitor 10074-g5 with improved cell permeability
The present invention relates compounds and compositions for interfering with the association of myc and max. These compounds and compositions are useful in methods for inhibiting growth or proliferation of a cell.
10/02/14
20140296230
 Dihydroquinazolinone analogues patent thumbnailDihydroquinazolinone analogues
Wherein the groups r1 to r4 and a1 to a5 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament..
10/02/14
20140296229
 Indolinone analogues patent thumbnailIndolinone analogues
Wherein the groups r1 to r4, a1 and a2 have the meanings given in the claims and in the specification. The compounds of the invention are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation pharmaceutical preparations containing such compounds and their uses as a medicament..
10/02/14
20140296166
 Bisphosphonate compositions and methods for treating and\or reducing cardiac dysfunction patent thumbnailBisphosphonate compositions and methods for treating and\or reducing cardiac dysfunction
The present invention provides for methods and compositions for treating, reducing and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, prodrug thereof, functional analogue or a pharmaceutically effective salt thereof in an amount sufficient to increase activity of at least one kinase in heart tissue of the subject.. .
10/02/14
20140296141
Compositions and methods for treating obesity, obesity related disorders and for inhibiting the infectivity of human immunodeficiency virus
The present invention relates to methods and pharmaceutical compositions for treating obesity or obesity-related disorders in a subject suffering from or predisposed to developing obesity or an obesity-related disorder, or for inhibiting the infectivity of hiv, by administering oleuropein, an analogue or derivative thereof, or the major metabolites of oleuropein including oleuropein aglycone, hydroxytyrosol, and elenolic acid or their analogues, or derivatives thereof, an iridoid glycoside, or a secoiridoid glycoside or analogues or derivatives thereof, or any combination of the foregoing including olive leave extract. The invention also relates to methods for screening/diagnosing a subject having, or predisposed to having obesity or a related disorder by measuring the expression profiles of an adipogenic gene selected from pparγ2, lpl and αp2 gene and gene product, or other adipogenic, lipogenic, or lipolytic genes and gene products in an individual.
10/02/14
20140296131
Truncated glp-1 derivatives and their therapeutical use
The invention relates to truncated glp-1 analogues, in particular a glp-1 analogue which is a modified glp-1(7-35) (seq id no 1) having: i) a total of 2, 3, 4, 5 6, 7, 8, or 9 amino acid substitutions as compared to glp-1(7-35), including a) a glu residue at a position equivalent to position 22 of glp-1(7-35), and b) an arg residue at a position equivalent to position 26 of glp-1(7-35); as well as derivatives thereof, and therapeutic uses and compositions. These analogues and derivatives are highly potent, have a good binding affinity to the glp-1 receptor, also to the extracellular domain of the glp-1 receptor, which is of potential relevance achieving long-acting, stable glp-1 compounds with a potential for once weekly administration..
10/02/14
20140295550
Hla peptide therapy
The invention provides polypeptides derived from a major histocompatibility complex (mhc) class i human leukocyte antigen (hla), such as hla-a2, and derivatives or analogues thereof. The polypeptides, derivatives and analogues can be used to treat or prevent allosensitisation, such as the treatment or prevention of allograft rejection..
10/02/14
20140295414
Methods and compositions for labeling nucleic acids
The present invention relates to methods for the labeling of nucleic acid polymers in vitro and in vivo. In particular, the methods include a [3+2] cycloaddition between a nucleotide analogue incorporated into a nucleic acid polymer and a reagent attached to a label.
10/02/14
20140295372
Device of computerized dental measurement and measuring method usable with said device
This device comprises a measuring clamp (1) for teeth (20) and dental spaces (21), comprising a set of mobile arms (2) ending in some exploration extremities (3), which exploring displacement along the teeth (20) and dental spaces (21) determines the joint displacement of the mobile arms (2). A transducer (11) turns the relative displacement movement between mobile arms (2), into signals (25) expressing the positional parameters (23) determined by that movement, and, upon being connected to a computerized system (30), it transmits the signals (25) for their processing as measurement parameters (23).
10/02/14
20140295280
Mgmn2o4 with a crystal structure analogue to cafe2o4, camn2o4, or cati2o4 as rechargeable magnesium battery cathode
A cathode active material for a battery includes a material of the formula mgxmn2o4 wherein 0≦x≦1 and the material has a crystal structure having an open channel formed in a single dimension or along a single dimensional axis. The crystal structure may be an analogue to cafe2o4, camn2o4 or cati2o4..
10/02/14
20140294931
Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders
Thyroid hormone antagonists and their nanoparticle formulations (nanotetrac™ or nanotriac™) act at a cell surface receptor to block angiogenesis and tumor cell proliferation. The complex anti-angiogenic performs actions on specific cytokines and chemokines.
10/02/14
20140294897
Potent lna oligonucleotides for the inhibition of hif-1a expression
The present disclosure relates to an lna oligonucleotide consisting of a sequence selected from the group consisting of 5′-(tx)gxgxcsasasgscsastscscstxgxt-3′ and 5′-(gx)txtxascstsgscscststscstxtxa-3′, wherein capital letters designate a beta-d-oxy-lna nucleotide analogue, small letters designate a 2-deoxynucleotide, underline designates either a beta-d-oxy-lna nucleotide analogue or a 2-deoxynucleotide, subscript “s” designates a phosphorothioate link between neighbouring nucleotides/lna nucleotide analogues, and subscript “x” designates either a phosphorothioate link or a phosphorodiester link between neighbouring nucleotides/lna nucleotide analogues, and wherein the sequence is optionally extended by up to five 2-deoxynucleotide units. The lna oligonucleotides are useful for modulating the expression of hypoxia-inducible factor-1a (hif-1a), e.g.
09/25/14
20140288962
Multi-media medical notes system (mmmns)
This invention develops a multi-media medical notes system (mmmns) that allows for the creation of the medical notes and integration with the medical records data bases. Its purpose is to provide an electronic format where the notes created during a patient's admission regarding daily examinations normally noted in analogue form could be organized to improve their presentation, accessibility, and integration.
09/25/14
20140288880
Sensor based means of monitoring the mechanical condition of rotating machinery that operates intermittently
A method of monitoring the mechanical condition of a machine in which statistically significant measurements on a characteristic signal are made over a period of time which can include interruptions and variations in the operation of the machine giving rise to uncharacteristic signals and the processing of the signal during the statistically significant measurement automatically excludes those parts of the signal associated with interruptions and variations in the operation of the machine. The invention also includes apparatus for carrying out the above method including a preamplifier, adapted to provide output to a further amplifier, adapted to provided output to dynamic enveloping circuitry, adapted to provide an output to an analogue to digital converter, adapted to provide an output to a digital micro-electronic device..
09/25/14
20140288862
Magnetic compensation circuit and method for compensating the output of a magnetic sensor, responding to changes in a first magnetic field
A solution for compensating a magnetic field sensor to permit detection of a small magnetic field in the presence of a large magnetic field is disclosed. A magnetic field sensor detects the magnetic field which produces an analogue signal then encoded by an analogue to digital converter (adc) into a digital stream.
09/25/14
20140288266
Synthesis of cyclosporin analogs
The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine a. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives.
09/25/14
20140288052
Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
09/25/14
20140287924
Novel strigolactone analogues and their use
Novel compounds of formula (i) their use as germination trap for parasitic weeds, for the regulation of branching, tillering and root development, for enhancement of cambium growth, for the regulation of hyphal growth of mycorrhizal fungi and compositions comprising compounds of formula (i) and insecticides and/or fungicides.. .
09/25/14
20140286895
Methods and compositions for promoting organ development
Compositions and methods are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or fetus. Compositions and methods are also provided for the administration of at least one colony stimulating factor-1 protein (csf-1), precursor, variant, analogue, derivative thereof, or combinations thereof, or otherwise, at least one nucleic acid molecule encoding colony stimulating factor-1 protein (csf-1), precursor, variant, analogue, derivative thereof, or combinations thereof..
09/18/14
20140275573
Method of producing beraprost
An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds..
09/18/14
20140275541
Total synthesis of thaxtomin a analogues and their intermediates
Improved synthetic methods for the production of thaxtomin analogues, particularly thaxtomin a, and intermediates therefore such as substituted tryptophans and in particular, 4-nitro-l-tryptophan, and substituted phenyl acrylic acids are disclosed. Bioassays show that the synthetic thaxtomin a is not significantly different from the natural one in herbicidal activity..
09/18/14
20140275520
Process for making a 4-amino-4-oxobutanoyl peptide cyclic analogue, an inhibitor of viral replication, and intermediates thereof
And pharmaceutically acceptable salts thereof.. .
09/18/14
20140274939
Combined systemic and topical treatment of disordered tissues
Kits and methods for treating disordered tissue caused by a virus in a mammal involve co-administration of a systemic anti-virus drug and topically administering an anti-infective composition. The systemic anti-virus drug is internally administered and disrupts or inhibits virus replication systemically within the mammal.
09/18/14
20140271873
Application of encapsulated capsaicin and analogues thereof for controlling calorie intake
A zero-calorie to near-zero-calorie snacking product that, when consumed, provides a feeling of fullness prior to absorption of energy-providing food, i.e., pre-absorptive satiation is disclosed. The snacking product is based on the stimulation of vagal nerve endings in the gastro-intestinal tract by encapsulated capsaicin.
09/11/14
20140257590
Signal determination apparatus and temperature determination apparatus
A temperature determination apparatus includes a signal detection section having an a/d input port, a thermistor that is connected to the a/d input port and outputs an analogue signal to the a/d input port, and a switch section that shifts a level of the analogue signal to a low level. The signal detection section determines that a control signal having a priority higher than that of an output detection process of the thermistor is generated when it is detected that the analogue signal to be input to the a/d input port is in the low level..
09/11/14
20140256952
Process for ixabepilone, and intermediates thereof
The present invention relates to a novel process of making ixabepilone, ixabepilone derivatives and analogues, and intermediates thereof.. .
09/11/14
20140256922
Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof.
09/11/14
20140256794
Activation of functional nucleic acid by specific modification
This invention is intended to enhance and improve the resistance of a single- or double-stranded nucleic acid fragment comprising a base sequence of a functional nucleic acid to degradation by nucleolytic enzymes in a simple and cost-effective manner. The single- or double-stranded nucleic acid fragment comprises, ligated to at least one 3′ end thereof, a hairpin-shaped dna comprising: (a) a nucleic acid region consisting of 2 to 5 arbitrary nucleotides; (b) a nucleic acid region consisting of a “gna” or “gnna” base sequence, wherein each “n” represents “g”, “t”, “a”, or “c”, a base analogue, or a modified base; and (c) a nucleic acid region consisting of a base sequence complementary to the nucleic acid region (a), sequentially ligated from the 5′ end toward the 3′ end, wherein at least one of two 3′ terminal nucleotides from at least one 3′ end of the single-stranded nucleic acid fragment or the double-stranded nucleic acid fragment is modified..
09/11/14
20140256665
Aminoglycoside and azole compositions and methods
The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring iii that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin a.
09/11/14
20140256646
Multi-leu peptides and analogues thereof as selective pace4 inhibitors and effective antiproliferative agents
Disclosed herein are pace4 inhibitors, compositions comprising pace4 inhibitors and their uses thereof for lowering pace4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering pace4 activity, reducing the proliferation of a cell, reducing tumor growth and/or treating and preventing cancer.
09/11/14
20140256640
Treatment of coagulopathy with hyperfibrinolysis
The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogs exhibit at therapeutically effective dosages an antifibrinolytic effect.
09/11/14
20140255991
Overexpression of aminoacyl-trna synthetases for efficient production of engineered proteins containing amino acid analogues
Methods for producing modified polypeptides containing amino acid analogues are disclosed. The invention further provides purified dihydrofolate reductase polypeptides, produced by the methods of the invention, in which the methionine residues have been replaced with homoallylglycine, homoproparglycine, norvaline, norleucine, cis-crotylglycine, trans-crotylglycine, 2-aminoheptanoic acid, 2-butynylglycine and allylglycine..
09/11/14
20140255591
Frozen dessert mixes using soy protein products
A soy protein product having a protein content of at least about 60 wt % (n×6.25) d.b., preferably at least about 90 wt %, and being completely soluble at ph values of less than about 4.4 and heat stable at such ph values is used to provide, at least in part, the protein component of a dairy analogue or plant/dairy blend frozen dessert mix.. .
09/11/14
20140253356
Digital-to-analogue converter
The invention relates to digital-to-analog converters for converting current. The converter includes a pair of differential branches with two transistors controlled by a digital register activated at a clock frequency, and two resistive loads receiving the currents of the differential branches to produce a differential electrical signal representing the analog result of the conversion.
09/11/14
20140253128
Fluid determination in a well bore
A fluid measurement system (10, 110, 210) and method of fluid mix determination over a sampling length (25) in a well bore (12). A pulse generator is nm in the well bore from which is suspended a cable (24) with two conductors having a length equal to the sampling length.
09/04/14
20140249194
Optically active fluconazole analogues containing thiophenes as antifungal agents
Wherein r5 is cn or coor′, where r′ is methyl or ethyl. The compounds of formula (1a) or formula (1b) may be used in pharmaceutical compositions for treating fungal infections..
09/04/14
20140249147
Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators
Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.
09/04/14
20140249105
Novel ceramide analogues, processes for preparing same and uses thereof
Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid.
08/28/14
20140243765
Percutaneously absorbable preparation containing fentanyl and homologue thereof
Disclosed is a transdermal preparation, comprising sequentially-stacked layers of a backing layer, a barrier layer, a drug adhesive layer and a release layer, wherein the drug adhesive layer contains a drug selected from the group consisting of fentanyl, an analogue thereof and a pharmaceutically-acceptable salt thereof, a skin permeation enhancer of the drug, and a polyacrylate adhesive, which shows a high skin permeation with a low drug dosage, equivalent to one with high drug dosage, by increasing the skin permeation rate of drug.. .
08/28/14
20140243257
Benzimidazole analogues for the treatment or prevention of flavivirus infections
Or pharmaceutically acceptable salts and solvates thereof, wherein a, b, b′, x, y, r1, r1′, r2, r2′, r3, r3′, r5, r5′, r6, m, n, or p are as defined herein, are useful for treating flaviviridae viral infections.. .
08/28/14
20140242932
Multi-channel radio-frequency receiver
The invention relates to a multichannel radio-frequency receiver for electromagnetic waves, having a radio-frequency analogue section, which has an input for an electrical signal from a reception device, and having a lower-frequency section, which is connected downstream of the radiofrequency analogue section and has a plurality of parallel channels (6b, 6c; 7b, 7c) for in each case different signal levels and an evaluation circuit, in which, in the radiofrequency analogue section in order to split the signal in accordance with a predeterminable division ratio into signal elements which can be supplied to radio-frequency analogue channels (6a, 7a), downstream from which the channels (6b, 6c; 7b, 7c) of the lower-frequency section are respectively connected, and the channels (6b, 6c; 7b, 7c) of the lower-frequency section each have an evaluation circuit for detection of the phase and amplitude of the respective signal element.. .
08/28/14
20140242574
Codon-optimized gene for mutated shrimp luciferase and method for use thereof
There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.
08/28/14
20140242190
Use of deoxyelephantopin (det) and analogues thereof for treatment of melanoma
Methods for preventing and/or reducing side effects of an anti-cancer agent in a subject in need thereof are disclosed. The method comprises administering to the subject, who is under an anti-cancer agent treatment, a composition comprising a therapeutically effective amount of isolated deoxyelephantopin and/or an analogue thereof; and a pharmaceutically acceptable carrier..
08/28/14
20140242169
Tapentadol compositions
The present invention provides a method of treating pain and pain related conditions by administering to a patient in need thereof, a therapeutically effective amount of a slow release tapentadol hydrochloride and therapeutically effective amount of a second analgesic, wherein the second analgesic is gamma-aminobutyric acid (gaba) analogue. The present invention further provides a pharmaceutical composition comprising a therapeutically effective amount of a slow release tapentadol hydrochloride and a therapeutically effective amount of a second analgesic, wherein the second analgesic is gamma-aminobutyric acid (gaba) analogue..
08/28/14
20140242097
Methods
A method for promoting entry of an agent (introduced agent) into a cell, the method comprising the step of complexing the introduced agent in the presence of an entry-promoting agent and then exposing to cells, wherein the entry-promoting agent comprises a linear and/or branched or cyclic polymonoguanide/polyguanidine, polybiguanide, analogue or derivative thereof according to the following formula 1a & b. The method also provides a means for formation of nanoparticles formed between the entry promoting agent and the introduced agent.
08/28/14
20140240157
Analogue to digital converter
An analogue to digital converter (adc) having a gated ring voltage controlled oscillator, grvco, to generate a phase signal according to an input voltage; and a quantization circuit to generate a quantized phase output signal according. The grvco operates in either a first or second mode of operation according to a gating control signal.
08/21/14
20140235844
Short interfering rna (sirna) analogues
The present invention is directed to novel double-stranded short interfering (sirna) analogues comprising locked nucleic acid (lna) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as rna interference (rnai).
08/21/14
20140235680
Desferrithiocin polyether analogues
Or a pharmaceutically acceptable salt thereof are useful in treating conditions such as metal overload, oxidative stress, and neoplastic and preneoplastic conditions.. .
08/21/14
20140235537
N-glycosylated insulin analogues
Compositions and formulations comprising n-glycosylated insulin analogues are described. In particular embodiments, the glycosylated insulin analogues are produced in vivo and comprise one or more the n-linked n-glycans selected from high mannose or fucosylated or non-fucosylated hybrid, paucimannose, or complex n-glycans.
08/21/14
20140234903
Biosynthetic gene cluster for the production of peptide/protein analogues
A novel gene cluster encoding polypeptides involved in the generation of bio synthetically unique peptide-based compounds is described. In addition, new methods for biosynthetic engineering and production of modified peptides and proteins are disclosed.
08/21/14
20140234251
Purine nucleoside analogues for treating flaviviridae including hepatitis c
This invention is directed to a method for treating a host, especially a human, infected with hepatitis c, flavivirus and/or pestivirus, comprising administering to that host an effective amount of an anti-hcv biologically active pentofuranonucleoside where the pentofuranonucleoside base is an optionally substituted 2-azapurine. The optionally substituted pentofuranonucleoside, or a salt or prodrug thereof, may be administered alone or in combination with one or more optionally substituted pentofuranonucleosides or other anti-viral agents..
08/21/14
20140234211
Supramolecular aggregates containing amphiphilic monomers, chelating agents and peptides for use for drug delivery and as contrast agents
Delivery systems based on liposomes functionalized with peptides and chelating agents, for therapy and imaging by selective targeting of tumour cells expressing the receptors grp, bb1, bb2, bb3 e bb4 and any other receptor which recognizes the bombesin peptide or analogues thereof are described. In particular, the liposomes contain within them cytotoxic drugs, such as for example doxorubicin, for target-selective antitumour therapy, and, through the presence of the chelating agent, can contain radioactive or paramagnetic ions for the real time visualization of the tumour cells.
08/14/14
20140228375
Sigma receptors ligands with anti-apoptotic and/or pro-apoptotic properties, over cellular mechanisms, exhibiting prototypical cytoprotective and also anti-cancer activity
The present invention involves new and original sigma receptors ligands: (mono-or dialkylaminoalkyl)-γ-butyrolactones, their analogues aminotetrahydroturanes, the (1-adamantyl) benzene alkylamines, the n,n dialkyl α-[(adamantyl-1)benzyloxy-2] alkylamines and the 3-cyclopentyl adamantyl-amines or alkylamines or-alkyl phenylamines, their enantiomers or diastereoisomers, their pharmaceutically acceptable salts and quinacrine me-thylene blue, asteinizole and their relative analogues with pro-apoptotic and/or anti-apoptotic properties over cellular biochemical mechanisms, with prototypical anti-cancer, antimetastatic and antiviral activities associated with antagonism of the neuropatic pain and, at very low doses, with cytoprotective and cytoregenerative activity against the cytodegenerative diseases.. .
08/14/14
20140228364
Ophthalmic compositions comprising prostaglandin f2 alpha derivatives and hyaluronic acid
The present invention relates to a composition comprising at least one analogue of prostaglandin as active compound, and a stabilizing amount of at least one hyaluronic acid or a salt thereof, said composition being preservative-free; and to the use thereof for use in treating ocular hypertension and/or glaucoma in a subject in need thereof.. .
08/14/14
20140227231
Laminins, derivatives, and compositions including same and methods for their therapeutic use
In various embodiments, the present disclosure provides a method of treating a subject using laminin or a composition that includes laminin. In one embodiment, the method is used to enhance muscle regeneration, maintenance, or repair in a subject.


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Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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