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This page is updated frequently with new Analogue-related patent applications.




Date/App# patent app List of recent Analogue-related patents
06/16/16
20160173815 
 Video signal attenuation equalization circuit, processing apparatus, and control device and method patent thumbnailVideo signal attenuation equalization circuit, processing apparatus, and control device and method
Disclosed are a video signal attenuation equalization circuit, a video signal processing apparatus, and a control device and method, which are used for solving the problem that the transmission of an analogue video signal is distorted after the analogue video signal is transmitted by a coaxial cable, so as to guarantee low signal distortion after the video signal is transmitted at a long distance. The video signal attenuation equalization circuit provided in the embodiments of the present invention comprises: a signal driving circuit, an equalization unit and an analogue switch unit, wherein the signal driving circuit is connected to the equalization unit and the analogue switch unit, and is used for receiving and strengthening an initial video signal, and sending the obtained strengthened initial video signal to the equalization unit and the analogue switch unit; the equalization unit is used for performing attenuation equalization on the strengthened initial video signal according to the triggering of a control signal, and after the attenuation equalization sending the video signal to the analogue switch unit; and the analogue switch unit is used for outputting the strengthened initial video signal or the video signal sent by the equalization unit after the attenuation equalization according to the control of the control signal..
Zhejiang Dahua Technology Co., Ltd.


06/16/16
20160172079 
 Use of a cable for the transmission of audio signals patent thumbnailUse of a cable for the transmission of audio signals
According to the invention, a cable (10) is used to transmit audio signals, in particular analogue audio signals. Said cable comprises at least two conductors (12.1, 12.2, 12.3, 12.4), a first connection piece on a first end of the cable (10) for connecting the cable (10) to a first device and a second connection piece on a second end of the cable (10) for connecting the cable (10) to a second device.

06/16/16
20160168226 
 Process for production of insulin and insulin analogues patent thumbnailProcess for production of insulin and insulin analogues
A process for production of insulin or insulin analogues by expression of insulin or insulin analogues through an expression vector in a host cell is provided. The expression vector includes a leader peptide of seq id no 3; a nucleotide sequence encoding an affinity tag linked to c-terminal end or n terminal end of nucleotide sequence of the leader peptide; and a nucleotide sequence encoding for a cleavage site ligated to nucleotide sequence of the leader peptide through nucleotide sequence encoding the affinity tag..
Biogenomics Limited


06/16/16
20160168225 
 Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists patent thumbnailExendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake. .
Sanofi


06/16/16
20160168124 
 Substituted pyridine-piperazinyl analogues as rsv antiviral compounds patent thumbnailSubstituted pyridine-piperazinyl analogues as rsv antiviral compounds
The invention concerns novel substituted pyridine-piperazinyl analogues of formula (i) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (rsv). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection..
Janssen Sciences Ireland Uc


06/16/16
20160166653 
 Chemically and thermodynamically stable insulin analogues and improved methods for their production patent thumbnailChemically and thermodynamically stable insulin analogues and improved methods for their production
The subject matter of this invention is directed towards chemically and thermodynamically stable single-chain insulin (sci) analogues that are resistant to deamidation and fibrillation. The invention further discloses improved methods for the recombinant expression, purification and refolding of sci..
Amidebio Llc


06/16/16
20160166639 
 Glycosylated pacap/vip analogues with enhanced cns penetration for treatment of neurodegenerative diseases patent thumbnailGlycosylated pacap/vip analogues with enhanced cns penetration for treatment of neurodegenerative diseases
A glycosylated pleiotropic peptide pituitary adenylate cyclase-activating polypeptide (pacap) which can both agonize pac1 receptors, causing neuroprotective effects, and antagonize vpac receptors, causing anti-inflammation in several models of acute neuronal damage and neurodegenerative diseases, including als, pd, migraines, and certain forms of dementia, is described. Also described is a method of relieving symptoms of als, pd, migraines, and certain forms of dementia, comprising administering to a subject in need thereof an effective amount of a glycosylated pacap..
The Arizona Board Of Regents On Behalf Of The University Of Arizona


06/16/16
20160166591 
 Compositions and methods to treat cardiac diseases patent thumbnailCompositions and methods to treat cardiac diseases
Phosphonate and phosphinate n-methanocarba derivatives of amp including their prodrug analogs are described. Mrs2339, a 2-chloro-amp derivative containing a (n)-methanocarba (bicyclo[3.1.0]hexane) ring system in place of ribose, activates p2x receptors, ligand-gated ion channels.
The United States Of America As Represented By The Secretary Department Of Health And Human Services


06/09/16
20160163261 
 Current sensing circuit and organic light emitting diode display including the same patent thumbnailCurrent sensing circuit and organic light emitting diode display including the same
Discussed are a current sensing circuit capable of compensating for degradation of an organic light emitting diode by sensing a current of the organic light emitting diode, and an organic light emitting diode display having the same. The current sensing circuit according to an embodiment includes a plurality of sensing modules configured to sense a pixel current from a display panel having an organic light emitting diode on each of a plurality of pixels, and to output a sensing voltage according to a sensing result; and an analogue-digital converter configured to convert the sensing voltage into an analogue-digital voltage, and to output sensing data..
Lg Display Co., Ltd.


06/09/16
20160159788 
 Method for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4as,7as)-octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid patent thumbnailMethod for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4as,7as)-octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
This invention relates to methods for preparation of chemical compound 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4a8,7as)-octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid, which comprise addition of heterocyclic amine containing protecting group, to ethyl-3-oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propanoate, followed by interaction with triethyl orthoformate, addition of cyclic amine, subsequent cyclization and formation of target product. The method for preparation claimed is technologically simple in comparison with analogue and requires no special complex technical operations, which in its turn simplifies method for preparation of this chemical compound, and reduces cost of the final product, while the commercial production utilizing the mehod claimed has low degree of environmental threat..

06/09/16
20160158416 

Scaffold for hard tissue regeneration containing active ingredient for treating osteoporosis and preparing method thereof


A scaffold for hard tissue regeneration comprising an active ingredient for treating osteoporosis and a preparation method thereof. The scaffold for hard tissue regeneration is prepared by the steps of mixing a polyphenol-based natural substance containing quercetein or genistein involved in the activation of osteoblasts and osteoclasts and the biofunctional analogue thereof with a ceramic scaffold material and molding the mixture at room temperature into a three-dimensional scaffold.
Korea Institute Of Machinery And Materials


06/09/16
20160158351 

Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants


Disclosed herein are pharmaceutical compositions comprising plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range plasmodium and analogues of α-galactosylceramide (α-galcer), a ligand for natural killer t (nkt) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria.
The Rockefeller University


06/09/16
20160158321 

Treatment of pediatric growth hormone deficiency with human growth hormone analogues


The present invention concerns a pediatric growth hormone deficiency (pghd) therapy for pediatric subjects. The therapy comprises administering to the pediatric patient with pghd a human growth hormone-xten (hgh-xten) fusion protein in therapeutically effective doses every week, every two weeks, semimonthly, every three weeks, or monthly.
Amunix Operting Inc.


06/09/16
20160158163 

Method for treating gefitinib-resistant non-small-cell lung cancer


The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (nsclc) comprising administering an effective amount of a resveratrol analogue, (z)3,4,5,4′-tetramethoxystilbene (tms), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant nsclc cells comprising contacting the resveratrol analogue to the cells at an effective amount.
Macau University Of Science And Technology


06/09/16
20160157479 

Antifungal composition and method


A composition comprising a surfactant, a co-surfactant, and a vanillin or an analogue thereof, that can be used to inhibit the growth of fungus on plants. The composition is diluted with water to form an oil-in-water microemulsion which can be applied to plants to inhibit the growth of fungus on plants..
Omex International Limited


06/02/16
20160157017 

Signal processing for mems capacitive transducers


This application relates to circuitry for processing sense signals generated by mems capacitive transducers for compensating for distortion in such sense signals. The circuitry has a signal path between an input (204) for receiving the sense signal and an output (205) for outputting an output signal based on said sense signal.
Cirrus Logic International Semiconductor Limited


06/02/16
20160152704 

Cadherin 15 agonists


Cdh15 has been identified as a receptor for a peptide which has an inhibitory effect of the migration of t cells. Agonists of this receptor have applications in the treatment and/or prophylaxis of conditions associated with the migration of t-cells, including t cell auto-reactivity, t cell mediated chronic inflammatory disease and autoimmune disease.
The University Of Birmingham


06/02/16
20160151446 

Peptide therapeutics and methods for using same


Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of an mpp, and/or naturally or artificially occurring variants or analogues of an mpp, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as d-arg-2′6′-dmt-lys-phe-nh2).. .
Stealth Biotherapeutics Corp


06/02/16
20160151343 

Non-flushing niacin analogues, and methods of use thereof


One aspect of the present invention relates to substituted pyridines and pharmaceutically acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the invention relates to a pharmaceutical composition, comprising a compound of the present invention or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.
Trustees Of Tufts College


05/26/16
20160145606 

Nuclease-resistant dna analogues


The present invention provides stable, nuclease-resistant tna and tna-dna oligonucleotides, wherein the oligonucleotides are completely resistant to enzymatic degradation for at least 24-72 hours. Methods of synthesis and use in diagnostic and therapeutic applications are also provided.

05/26/16
20160145575 

Methods of generating cells with multilineage potential


The present invention relates to methods for generating mammalian multilineage-potential cells, including mesenchymal stem cells, comprising contacting mammalian somatic cells exhibiting a mature phenotype with pdgf-ab or functional derivative, fragment or mimetic thereof and azacitidine or functional derivative or analogue thereof for a time and under conditions sufficient to induce the transition of the somatic cells to cells exhibiting multilineage differentiative potential. Also provided are uses of said multilineage-potential cells, such as in promoting tissue repair and regeneration..
Newsouth Innovations Pty Limited


05/26/16
20160145314 

Compositions and methods of using therapeutic p53 peptides and analogues


The present invention relates to compositions useful in inhibiting bcl-xl or mcl-1 and disrupting p53-mdm2 and p53-mdmx interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide..
University Of The Sciences Of Philadelphia


05/26/16
20160143998 

Glp-1 derivatives and uses thereof


The invention relates to a derivative of a glp-1 analogue, optionally c-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a c20 or c22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an oeg-like linker element; wherein these elements are interconnected via amide bonds and attached to a lys residue of the glp-1 analogue. The invention also relates to intermediate products in the form of novel glp-1 analogues incorporated in the derivatives of the invention, as well pharmaceutical compositions and medical uses of the derivatives.
Novo Nordisk A/s


05/26/16
20160143907 

Methods and compositions for treating clostridium difficile associated disease


Methods for treating a subject infected with clostridium difficile comprises administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of clofazimine and/or a clofazimine analogue. Pharmaceutical compositions comprising clofazimine and/or an analogue(s) thereof, and optionally one or more additional therapeutic agents, are provided for treating clostridium difficile infection and diseases or symptoms associated therewith..
Kamtek, Inc.


05/19/16
20160142809 

Wiring structure for electroacoustic transducer for digital signal and headphone for digital signal


A wiring structure is provided for an electroacoustic transducer directly converting digital signals from a single sound source to sound waves without conversion to analogue signals. The structure includes a diaphragm, and a plurality of voice coils fixed to the diaphragm.
Kabushiki Kaisha Audio-technica


05/19/16
20160142461 

Method and device for transmission of multimedia data


The present disclosure discloses a method for transmission of multimedia data, which includes: converting analogue multimedia data received from a terminal to digital multimedia data; separating the digital multimedia data into digital audio data and digital video data, and converting coding format of the digital video data; compressing the digital audio data and the digital video data in converted thecoding format respectively, converting protocol format of the compressed digital audio data and of the compressed digital video data respectively, and sending the resulting digital audio data and the resulting digital video data to a network. The present disclosure further discloses a device for transmission of multimedia data.
Zte Corporation


05/19/16
20160142097 

Energy-efficient system for distant measurement of analogue signals


An energy-efficient system for measurement of analogue signals including one or more measuring units. Each measuring unit has a measuring probe which signal is processed by a modulator.
Elektrotehnicki Fakultet Sveucilista U Osijeku


05/19/16
20160139129 

Biomarkers for the diagnosis and the response to treatment of pancreatic cancer


The invention related to biomarkers, a method and a kit for early diagnosis of pancreatic cancer, in particular of pancreatic ductal adenocarcinoma (pdac); and to biomarkers, a method and a kit or device for predicting or prognosticating an individual's response to combination treatment with a nucleoside analogue (preferably gemcitabine) and with a growth factor receptor (preferably erlotinib) in patients with pancreatic ductal adenocarcinoma.. .
Universidad De JaÉn


05/19/16
20160139018 

Flat panel test hardware and technology for assessing ballistic performance of helmet personnel protective equipment


A testing apparatus to assess ballistic performance of helmet personnel protective equipment having a flat helmet analogue with a helmet shell material in flat panel form and at least one helmet suspension pad; head surrogate components including a skull skin surrogate, a skull bone surrogate, and a brain tissue surrogate; a pressure indicating film adjacent to the head surrogate components; and one or more pressure sensors in the brain tissue surrogate. Also disclosed is the related method for assessing ballistic performance of helmet personnel protective equipment..

05/19/16
20160137712 

Fusion proteins with dual receptor agonist activities


The present disclosure relates to heterodimeric fusion proteins comprising two polypeptides, the first polypeptide comprising a first peptide (p1), a linker (l1), and a fc region (f1), the second polypeptide comprising a second peptide (p2), a linker (l2), and an fc region (f2), wherein p1 and p2 are each independently selected from glp-1, glp-1 analogues, glucagon, glucacon analogues, gip, gip analogues, oxyntomodulin, oxyntomodulin analogues, exendin and exendin analogues; wherein f is selected from an igg fc, an iga fc, an ige fc, an iggm fc, and their analogues; wherein the c-terminals of the peptides are linked, though the linker l, to the n-terminals of the fc region f. In one embodiment, the fusion proteins disclosed herein have agonist activity against at least two of the glp-1 receptor, the gip receptor, and the glucagon receptor..
Askgene Pharma, Inc.


05/19/16
20160136267 

Sphingoglycolipid analogues


The invention relates to sphingoglycolipid analogues which are useful in treating or preventing diseases and conditions such as those relating to infection, atopic disorders, autoimmune diseases or cancer.. .
Victoria Link Limited


05/19/16
20160136233 

Novel cyclosporin analogues for preventing or treating hepatitis c infection


The present invention relates to novel cyclosporine analogues having antiviral activity against hcv and useful in the treatment of hcv infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds..
Enanta Pharmaceuticals, Inc.


05/12/16
20160134705 

Digital sensor for a can network of a vehicle


Digital sensor for a can network of a vehicle, comprising a casing (4) which comprises a first portion (56) provided with a housing (60) capable of receiving a first electrical cable (8) and a second electrical cable (10), said first portion (56) receiving a first electrical component (24) and a second electrical component (26) respectively arranged opposite said housing (60), and which first electrical component (24) and second electrical component (26) each have a substantially flat surface adapted to constitute a capacitive element with respectively a portion (14) of said first electrical cable (8) and a portion (16) of said second electrical cable (10), such that, when said first electrical cable (8) and said second electrical cable (10) are received in said housing (60) and each carry a respective can digital signal, said first electrical component (24) and said second electrical component (26) carry an electrical signal corresponding to the digital can signal respectively carried on said first electrical cable (8) and on said second electrical cable (10), and a second portion (58) receiving an electronic circuitry (6) connected to said first electrical component (24) and said second electrical component (26), and arranged on the one hand to process the electrical signals which they carry in order to rebuild a first analogue signal and a second analogue signal which reflect the digital can signal respectively carried by the first electrical cable (8) and the second electrical cable (10), and on the other hand to transform the first analogue signal and the second analogue signal into respective digital can signals towards an output (12) connected to said electronic circuitry (6).. .
Masternaut Holdings Limited


05/12/16
20160134290 

Gray counter and analogue-digital converter using such a counter


An n-bit gray counter, with n an integer greater than 1, comprises a string of n logic cells connected in cascade, wherein each logic cell comprises an input port for a succession of clock pulses, a circuit for generating a gray count bit having an output port for the gray count bit and a circuit for generating a clock signal having a clock output port linked to the input port of the following logic cell. An analogue-digital converter of ramp type using such a gray counter is also provided..
Pyxalis


05/12/16
20160130647 

Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing


Novel fluorescent nucleotide analogues are provided herein. Also provided herein are methods of using the nucleotide analogues in sequencing-by-synthesis and signal confinement methods..
Complete Genomics, Inc.


05/12/16
20160130644 

Thiolated nucleotide analogues for nucleic acid synthesis


The present disclosure provide systems, compositions, methods, reagents, kits and products for extending a nucleic acid that includes incorporating a nucleotide residue at a terminus of a nucleic acid using a polymerase enzyme and at least one nucleotide, wherein the at least one nucleotide includes a thiophosphate moiety, and wherein the at least one nucleotide is resistant to hydrolysis by phosphatase. In some embodiments, the nucleotide incorporation can be conducted in the presence of a phosphatase.
Life Technologies Corporation


05/12/16
20160130304 

Novel cyclosporin analogues for preventing or treating hepatitis c infection


The present invention relates to novel cyclosporine analogues having antiviral activity against hcv and useful in the treatment of hcv infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds..
Enanta Pharmaceuticals, Inc.


05/12/16
20160130296 

Oligonucleotide analogues incorporating 5-aza-cytosine therein


Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2′-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (dpg and gpd) are provided to target the cpg islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation.
Astex Pharmaceuticals, Inc.


05/12/16
20160129139 

Method for purification of 18f-labeled choline analogues


The present invention relates to a method for purification of 18f-labeled choline analogues in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (spe) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18f-labeled choline analogues.. .
Trasis S.a.


05/12/16
20160129083 

Mic-1 fusion proteins and uses thereof


The invention relates to mic-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a mic-1 protein or an analogue thereof at the c-terminus of the fusion protein and a functional variant of human serum albumin at the n-terminus of the fusion protein connected via a peptide linker.
Novo Nordisk A/s


05/12/16
20160128958 

Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma


Therapeutic methods relating to the use of gaba-at inhibitor compounds for the treatment of hepatocellular carcinoma.. .

05/12/16
20160128953 

Trans-clomiphene and its analogues as agents that increase bone mineral density


The present invention relates to the administration of compositions comprising trans-clomiphene or an analogue or salt thereof, for inhibiting bone resorption and bone turnover in a subject. The invention is also directed to methods for increasing bone mineral density in a subject and preventing or treating a bone related disorder in a subject comprising administering to the subject an effective amount of trans-clomiphene or an analogue or salt thereof..
Repros Therapeutics Inc.


05/05/16
20160126968 

Analogue-to-digital converter


This application relates to analogue-to-digital converters (adcs). An adc 200 has a first converter (201) for receiving an analogue input signal (ain) and outputting a time encode signal (dt), such as a pulse-width-modulated (pwm) signal, based on input signal and a first conversion gain setting (gin).
Cirrus Logic International Semiconductor Ltd.


05/05/16
20160123850 

Method of forming a stain assessment target


A method is provided of forming a stain assessment target for a biological material staining system. At least one region of a substrate is provided upon a support such as a microscope slide.
Ffei Limited


05/05/16
20160122403 

Ghrelin splice variant for treating neuronal damage,neurodegenerative disease, parkinsons disease, alzheimers disease, and/or depression


The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof, or a ghrelin splice variant-like compound for the preparation of a medicament for one or more of: treatment and/or prevention of neuronal damage and/or neurodegeneration and, prophylaxis or treatment of neuronal damage and/or neurodegenerative disease, parkinson's disease, alzheimer's disease, depression stimulation of neuronal activity. A further aspect relates to a number of new ghrelin splice variant-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds..

05/05/16
20160122303 

Biocatalyzed synthesis of the optically pure (r) and (s) 3-methyl-1,2,3,4-tetrahydroquinoline and their use as chiral synthons for the preparation of the antithrombic (21r)- and (21s)-argatroban


The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3r) and (3s)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in particular, for the preparation of diastereomerically pure (21r) and (21s)-agratroban and its analogues.
Euticals S.p.a.


05/05/16
20160120971 

Immunogenic composition comprising neisseria meningitidis macrophage infectivity potentiator protein and methods for using them


An immunogenic composition comprising the nm-mip protein or an immunogenic part thereof or an analogue thereof, wherein the composition is capable of eliciting an immune response when administered to a human or non-human animal, and uses thereof. A pharmaceutical composition or a vaccine composition comprising the nm-mip protein or an immunogenic part thereof or an analogue thereof..
University Of Southampton


05/05/16
20160120951 

Acylated glucagon analogues


The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods.
Zealand Pharma A/s


05/05/16
20160120883 

Anti-infective hydroxy-phenyl-benzoates and methods of use


The invention provides a method for preventing or treating a disease caused by an extracellular microorganism, said method comprising systemically administering to a subject in need thereof a prophylactically or therapeutically effective amount of a salicylic acid (sal) or a sal analogue. The extracellular microorganism can be of the bacterial genus staphylococcus, for example, staphylococcus aureus.
Los Angeles Biomedical Research Institute At Harbor-ucla Medical Center


05/05/16
20160120857 

Anti-fibrogenic compounds, methods and uses thereof


Presented herein are methods for treatment of diseases or conditions related to fibrosis. Compounds, or pharmaceutically acceptable salts thereof or pharmaceutical compositions thereof provide for the treatment of diseases or conditions related to fibrosis.
The University Of British Columbia


05/05/16
20160120853 

Tacrolimus and analogues thereof for medical use


The present invention relates to a method of treating adverse fat accumulation and related conditions with very low doses of tacrolimus or a close structural analogue thereof. In particular this invention relates to treating adverse fat accumulation and/or sarcopenia and/or metabolic syndrome inpatients by administering tacrolimus in very low dose.
Chronos Therapeutics Limited


04/28/16
20160115216 

Method for making mature insulin polypeptides


This invention relates to an improved method for making mature human insulin or an analogue thereof by cultivating fungi cell comprising a dna sequence encoding a precursor for human insulin or an analogue thereof, which precursor comprises a small connecting peptide.. .
Novo Nordisk A/s


04/28/16
20160115179 

Spiro-oxazines, indolinones and preparation thereof


The present invention relates to novel spiro-oxazine analogues of formula-i and indolinone compounds of formula-ii or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-i formula-ii further the invention provides transition-metal free multicomponent reaction (mcr) process for the preparation of said compounds of formula-i and ii using aryne precursor, n-substituted isatin and n-heteroaromatic compound as the nucleophile, under mild condition leading to formation of desired complex of spiro-oxazine analogues (i) and indolinone analogues (ii) in high yield and selectivity..
Council Of Scientific & Industrial Research


04/28/16
20160115173 

Methods and compositions for studying, imaging, and treating pain


In embodiments, the present disclosure provides a method for alleviating pain in a subject in need of treatment, the method comprising administering to the subject an effective amount of a saxitoxin analogue compound, or a pharmaceutically acceptable salt, isomer, tautomer or prodrug thereof, whereby pain in said subject is alleviated.. .

04/28/16
20160115112 

Novel n-3 immunoresolvents: structures and actions


The invention describes novel mono-hydroxy, di-hydroxy and tri-hydroxy docosapentaenoic acid (dpa) analogues, their preparation, isolation, identification, purification and uses thereof. Resolution of inflammation is now held to be an active process where autacoids promote homeostasis.
The Brigham & Women's Hospital Inc.


04/21/16
20160112796 

Analogue signal processing circuit for microphone


An analog signal processing circuit of a microphone includes a bias circuit including a first sub-circuit which receives a signal from the microphone to output a first signal and a second sub-circuit which receives a reference voltage to output a second signal. A fully differential circuit receives the first signal and the second signal to output a fully differential signal.

04/21/16
20160107977 

Methods of synthesis of ingenol and intermediates thereof


The present invention relates generally to methods of synthesis of diterpene heterocylic compounds. More particularly, the present invention relates to efficient methods of synthesis of ingenol (formula (21), cas 30220-46-3), from a compound of formula (1).

04/21/16
20160106768 

Lysophospholipids and lysophospholipid analogues against honeybee brood diseases


The present invention refers to a compound selected from the group consisting of a lysophospholipid and a lysophospholipid analogue for use in the treatment or prophylaxis of honeybee brood diseases, in particular american foulbrood and european foulbrood. The invention also refers to a diet composition, a sprayable composition, a dipping solution for brood combs, a beeswax composition and liposomal and microsphere- or nanosphere-based compositions, comprising a compound according to the invention, for use in the treatment or prophylaxis of bee brood diseases..

04/14/16
20160104404 

Detection circuit and a liquid crystal display


A detection circuit and a detection method for liquid crystal display are provided. The detection circuit comprises a gate driver for providing row scan signal to liquid crystal cell to be detected; a signal source for providing polarity inversion signal to source driver; a source driver for performing digital-analogue conversion on received display data signal according to preset reference voltage and polarity inversion signal, generating pixel voltage signal, and sending pixel voltage signal to liquid crystal cell to be detected.

04/14/16
20160103527 

Identification and data interchange system having a portable capacitive device and a capacitive touch screen


The general field of the invention is that of systems having a capacitive touch screen. The system according to the invention has a portable capacitive device that is intended, in operational mode, to be carried by a user.

04/14/16
20160102307 

Oligonucleotide analogues targeting human lmna


Provided are lmna-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced lmna mrna isoforms that encode progerin.. .

04/14/16
20160102126 

Novel peptides involved in energy homeostasis


The expression of a mrna encoding a putative 76 amino acid, secreted protein (“enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of enho1 mrna in two mouse models of obesity, kk-ay and lepob/lepob mice.

04/14/16
20160101158 

Peptide therapeutics and methods for using same


Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of glp-1, and/or naturally or artificially occurring variants or analogues of glp-1, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as d-arg-2′6′-dmt-lys-phe-nh2).. .

03/31/16
20160094927 

Headphone device


The invention provides an apparatus that allows the user or a third party to easily monitor the volume levels of a set of headphones before and during use so as to prevent damage to the anatomy of the user's ears as a result of exposure to excessive noise volume. An analogue meter indicative of the signal level being input to or reproduced by the transducer within one or both of the headphone cans is provided, built into the outer surface of the headphone can so that it is easily visible to a user who is about to put on the headphones, or to a third party viewing the user wearing the headphones.
Ashdown Design & Marketing Limited


03/31/16
20160090621 

Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis


This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.. .
The Trustees Of Columbia University In The City Of New York


03/31/16
20160090579 

Modified polymerases for improved incorporation of nucleotide analogues


Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.. .
Illumina, Inc.


03/24/16
20160087614 

System for generating an analogue signal


The system has: a set of at least two electric current generators, at least one capacitor and activation/deactivation devices for the electric current generators; the electric current generator being connected in parallel with one another and the capacitor being connected in series with the electric current generators, the activation/deactivation devices controlling the generators by a digital stream allowing control of the intensity of the electric current entering the capacitor and generating a trapezoidal voltage signal at the terminals of the capacitor, the analog signal being reconstructed through interpolation of the trapezoidal signal.. .
Atlantic Innovation Electronic Solutions


03/24/16
20160084703 

Detection of radiation quanta using an optical detector pixel array and pixel cell trigger state sensing circuits


The invention relates to a radiation detection device for integrating the number of optical photons in a light pulse. A system, a method and a computer program product are also disclosed.
Koninklijke Philips N.v.


03/24/16
20160084073 

High temperature downhole gauge system


A gauge system and method for monitoring well pressure at temperatures in excess of 300° c. Used in permanent monitoring of oil and gas wellbores.
Zenith Oilfield Technology Limited


03/24/16
20160083448 

Site 2 insulin analogues


An insulin analogue contains one or more modifications at a distinct protein surface comprising one or more of the residues at position b13, b17, a12, a13, and/or a17. Formulations of the above analogues at successive strengths u-100 to u-1000 in soluble solutions a at least ph value in the range 6.8-8.0 either in the presence of zinc ions at a molar ratio of 2.2-10 zinc ions per six insulin analogue monomers or in the presence of fewer than 1 zinc ions per six insulin analogue monomers.
Case Western Reserve University


03/24/16
20160083447 

Double-acylated glp-1 derivatives


The invention relates to a derivative of a glp-1 analogue, which analogue comprises a first k residue at a position corresponding to position 27 of glp-1(7-37) (seq id no: 1); a second k residue at a position corresponding to position t of glp-1(7-37), where t is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to glp-1(7-37); wherein the first k residue is designated k27, and the second k residue is designated kt; which derivative comprises two albumin binding moieties attached to k27 and kt, respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from hooc—(ch2)x—co— and hooc—c6h4—o—(ch2)y—co—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —nh—(ch2)2—(o—(ch2)2)k(ch2)n—co—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel glp-1 analogues.
Novo Nordisk A/s


03/17/16
20160078255 

Method and device for reading rfid/uhf label based on audio interface


A method and a device for reading rfid/uhf label based on an audio interface are disclosed. According to the method, a built-in software module in an electronic device converts a first digital signal into an analogue signal capable of being transmitted via the audio interface; the analogue signal received by the audio interface is converted into a second digital signal via an audio communication circuit; then the rfid/uhf controller for digital signal control reads information from the rfid/uhf label; the rfid/uhf controller modulates and sends signals of a plurality of different frequency points, and the signal of every frequency point forms a signal channel.
Xiamen Innov Electronics Tech Co., Ltd.


03/17/16
20160077175 

Magnetic resonance imaging apparatus


According to one embodiment, an mri apparatus includes a bed, a digital processing circuit, a first antenna, first radio communication circuitry, a second antenna, second radio communication circuitry, and an image reconstruction circuit. An object is loaded on the bed.
Kabushiki Kaisha Toshiba


03/17/16
20160077042 

Phosphate sensor, its use and its preparation


A phosphate sensor employs a membrane which comprises a molecularly imprinted polymer produced from a thiourea derivative as functional monomer and a phosphate analogue (e.g. Phenylphosphonic acid) as template.
Yorkshire Water Services Limited


03/17/16
20160076070 

Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients


And wherein said nas are active as pharmaceutically relevant antivirals and anticancer medicaments, intermediates or prodrugs thereof.. .

03/17/16
20160075750 

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.

03/17/16
20160075741 

Cyclosporine analogue mixtures and their use as immunomodulating agents


The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine a. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives.
Aurinia Pharmaceuticals Inc.


03/17/16
20160075652 

Synthetic analogues of xanthohumol


The present invention relates to novel synthetic analogues of xanthohumol and the use thereof.. .
Azienda Ospedaliera Arcispedale Santa Maria Nouva / Irccs Istituto In Tecnologie Avanzate E Modelli




Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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