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Date/App# patent app List of recent Analogue-related patents
07/30/15
20150215141 
 Method and device to control the gain of a radio receiver patent thumbnailnew patent Method and device to control the gain of a radio receiver
An automatic gain control (agc) method and system for a radio receiver are proposed in which the acg comprises two agc loops; a first loop controlling signal gain in the analogue portion of the radio receiver, a second loop controlling gain in the digital domain after digitization of the received signal. The analogue agc loop has a slower response time than the digital agc loop.
Ericsson Modems Sa


07/30/15
20150212078 
 Pro-substrates for live cell applications patent thumbnailnew patent Pro-substrates for live cell applications
Provided are pro-substrates useful in assays of living cells. The pro-substrates can be used to detect the presence or absence of enzymes, such as luciferase, in living cells.
Promega Corporation


07/30/15
20150210748 
 Protease stabilized acylated insulin analogues patent thumbnailnew patent Protease stabilized acylated insulin analogues
Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain b25h and a14e or a14h..
Novo Nordisk A/s


07/30/15
20150210747 
 Protease stabilized acylated insulin analogues patent thumbnailnew patent Protease stabilized acylated insulin analogues
Novel acylated insulin analogues exhibiting resistance towards proteases can, effectively, be administered pulmonary or orally. The insulin analogues contain b25h and a14e or a14h..
Novo Nordisk A/s


07/30/15
20150210745 
 Double-acylated glp-1 derivatives with a linker patent thumbnailnew patent Double-acylated glp-1 derivatives with a linker
The invention relates to a derivative of a glp-1 analogue, which analogue comprises a first k residue at a position corresponding to position 18 of glp-1(7-37) (seq id no: 1), a second k residue at another position, and a maximum of twelve amino acid changes as compared to glp-1(7-37); which derivative comprises two protracting moieties attached to said first and second k residue, respectively, via a linker, wherein the protracting moiety is selected from hooc—(ch2)x-co—*, and chem. 1: hooc—c6h4-0-(ch2)y-co—*, chem.
Novo Nordisk A/s


07/30/15
20150210744 
 Glucagon analogues patent thumbnailnew patent Glucagon analogues
The present invention relates to glucagon analogues and their medical use, for example in the treatment of hypoglycaemia. In particular, the present invention relates to stable glucagon analogues suitable for use in a liquid formulation..
Zealand Pharma A/s


07/30/15
20150210714 
 Novel rapamycin analogue patent thumbnailnew patent Novel rapamycin analogue
There is provided inter alia a compound of formula (i) or a pharmaceutically acceptable salt thereof and its use in therapy.. .
Buck Institute For Research On Aging


07/30/15
20150210653 
 Analogues of porphyrins, their  preparation and use thereof patent thumbnailnew patent Analogues of porphyrins, their preparation and use thereof
The present invention relates to compound of formula (i), their method of preparation and use thereof in particular in the fields of optoelectronic, photonic, photovoltaics and biology.. .
Université D'aix-marseille


07/30/15
20150209411 
 Treatment of osteoarthritis with incretin hormones or analogues thereof patent thumbnailnew patent Treatment of osteoarthritis with incretin hormones or analogues thereof
The present invention relates to the use of the incretin hormones glucagon-like peptide-1 or glp-1 and glucose-dependent insulinotropic polypeptide or gip, or of analogues thereof, in particular the analogues resistant to dipeptidyl peptidase iv, in the treatment of osteoarthritis, in particular for inhibiting or slowing down cartilage destruction.. .
Universite Pierre Et Marie Curie (paris6)


07/23/15
20150203524 
 New  polyphosphate synthesis patent thumbnailNew polyphosphate synthesis
The subject of the invention is a new method of the synthesis of polyphosphate analogues, such as nucleosides, oligonucleotides, carbohydrates, peptides and proteins, which are of biological importance and are used in organic chemistry, molecular biology and biotechnology. Polyphosphate analogues, including in particular nucleoside 5′-triphosphates, display high biological activity and are responsible for the provision and storage of energy in live organisms.
Instytut Chemii Bioorganicznej Polskiej Akademii Nauk


07/23/15
20150203442 

Anthraquinone analogs and methods of making and using thereof


Rhein analogues that exhibit anti-proliferative activity, particular against cancer cells, are described herein. In some embodiments, the compounds contain a flat or planar ring system.
Children's Healthcare Of Atlanta


07/16/15
20150197800 

Massive parallel decoding dna and rna


This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analogue after the nucleotide analogue is incorporated into a growing strand of dna in a polymerase reaction. The invention also provides nucleotide analogues which comprise unique labels attached to the nucleotide analogue through a cleavable linker, and a cleavable chemical group to cap the —oh group at the 3′-position of the deoxyribose..
The Trustees Of Columbia University In The City Of New York


07/16/15
20150197550 

Therapeutic uses of dogfish glucagon and analogues thereof


The present invention relates to peptides of 12 to 50 amino acids in length which incorporate the amino acid sequence mdnrrak for use in the treatment of obesity, type-2 diabetes or metabolic syndrome.. .
University Of Ulster


07/16/15
20150197539 

Novel chartreusin analogues


The present invention relates to novel chartreusin analogues of formula (i), pharmaceutical compositions comprising the same and to their use for the treatment of cancer and other diseases.. .
Leibniz-institut Für Naturstoff-forschung Und Infektionsbiologie, Hans Knöll Institut


07/16/15
20150197522 

Inauhzin analogues that induce p53, inhibit cell growth, and have antitumor activity


Inauhzin (inz) was identified as a novel p53 activator, which selectively and efficiently suppressing tumor growth without displaying genotoxicity and with little toxicity to normal cells. A panel of inz analogs were synthesized and evaluated their ability to induce cellular p53 and to inhibit cell growth in cell-based assays.
Indiana University Research And Technology Corp.


07/16/15
20150196569 

Pharmaceutical compositions for the treatment of inner ear disorders


The present invention provides compositions containing (i) a pharmaceutically active agent selected from a group consisting of an arylcycloalkyamine or a derivative, analogue or pharmaceutically active salt thereof, and (ii) a biocompatible polymer or a combination of biocompatible polymers. These compositions or medicaments containing these compositions may be used for the prevention and/or treatment of inner ear diseases, e.g.
Auris Medical Ag


07/16/15
20150196249 

Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine


The present invention generally relates to compositions comprising anesthesia-reversing agents which facilitate or increase the time of awakening or reverse the effects of general anesthesia-induced unconsciousness. In some embodiments, the anesthesia reversing agent can be selected from any or a combination of methylphenidate (mph), amphetamine, modafinil, amantadine, caffeine, or analogues or derivatives thereof.
The General Hospital Corporation


07/09/15
20150195792 

Thermal noise floor estimation robustness via multi-carrier combining


The present invention provides methods and arrangements 300 which are configured to determine a noise rise estimates in a radio access node of a radio network system 100 supporting multi-carrier high-speed packet access transmission of user radio traffic between a radio access node and one or more user equipments. The arrangement is provided with a combiner combining the estimated thermal noise power floors of all carriers of a set of carriers sharing the same antenna branch, into a single thermal noise power floor estimate, valid for all carriers in said set of carriers sharing the same analogue signal path.
Telefonaktiebolaget L M Ericsson (publ)


07/09/15
20150194975 

Analogue-to-digital converter


An analogue-to-digital converter for converting an analogue input signal into a digital output signal, the analogue-to-digital converter including two conversion paths, each configured to receive a version of the analogue input signal and convert it into a digital bit stream, a first feedback loop configured to provide feed-back, to both paths, that is indicative of a difference between the digital bit streams output by the two paths, and a second feedback loop configured to feed-back, to both paths, that is indicative of an average of the digital bit streams output by the two paths.. .
Cambridge Silicon Radio Limited


07/09/15
20150194616 

Tetradentate platinum and palladium complex emitters containing phenyl-pyrazole and its analogues


A phosphorescent emitter or delayed fluorescent and phosphorescent emitters represented by formula 1 or formula ii, where m is platiunum or palladium.. .

07/09/15
20150191503 

Organic compounds


This invention relates to sphingoglycolipid analogues, compositions comprising these compounds, processes for preparing the compounds, and methods of treating or preventing diseases or conditions using the compounds, such as diseases or conditions relating to infection, atopic disorders, autoimmune disease, diabetes or cancer.. .
Callaghan Innovation Research Limited


07/09/15
20150191501 

Advanced glycation end product analogues


Disclosed are processes for the production of composition comprising one or more fructose amino acids, said process comprising the steps of: (a) providing plant material derived from a botanical source selected from plants of the families solanaceae, compositae, (asteraceae), guttiferae, umbelliferae, papaveraceae, vitidaceae or acanthaceae; (b) extracting one or more fructose amino acid(s) from said plant material; and optionally (c) detecting the presence and/or measuring the amount of said fructose amino acid(s) in the extract of step (b).. .
Phytoquest Limited


07/09/15
20150190472 

Use of the angiotensin-(1-9) peptide or derivatives thereof, use of vectors overexpressing the ace2 enzyme that produces angiotensin-(1-9) for preparing medicaments useful for preventing, reverting, inhibiting and/or reducing hypertension and/or inducing vasodilation


The present invention is related to the use of the angiotensin-(1-9) peptide or peptides derived therefrom, which are biological or chemical analogues, for preparing medicaments useful for preventing, reverting, inhibiting and/or reducing hypertension and/or inducing vasodilation. Furthermore, this invention also comprises a vector overexpressing the homologous angiotensin-ii converting enzyme (ace2) for elevating the concentration in the blood and/or tissues of the angiotensin-(1-9) peptide.
Universidad De Chile


07/09/15
20150190461 

Dosing instructions for endotoxin-binding lipopeptides


The invention relates to an endotoxin-binding lipopeptide selected from the group consisting of polymyxins, polymyxin derivatives, polymyxin analogues, prodrugs thereof and pharmaceutically acceptable salts thereof, and also relates to a preparation for parenteral administration comprising a lipopeptide of this type, for prophylaxis or for treatment of diseases and conditions caused by endotoxemia, by i) parenterally administering a bolus of the lipopeptide to achieve a lipopeptide serum concentration of 0.01 μg/ml to 0.8 μg/ml and ii) maintaining this lipopeptide serum concentration by parenterally administering the lipopeptide over a specifiable period of time.. .
Zentrum Für Biomedizinische Technologie Der Donau- Universität Krems


07/09/15
20150190385 

Thiazolidinedione analogues


The present invention relates to thiazolidinedione analogues that are useful for treating metabolic inflammation mediated diseases such as diabetes.. .
Metabolic Solutions Development Company, Llc


07/02/15
20150185039 

Contact-analogue display, in particular of a lane change


A method is disclosed for the contact-analogue display of a navigation instruction for a driving maneuver, particularly a lane change, of a vehicle, wherein the driving maneuver can be carried out at any point of a cohesive driving route of a road. The method includes: contact-analogue stationary displaying of the instruction at the beginning of the driving route for a first distance traveled by the vehicle; adapting the contact-analogue display of the instruction to the change of position of the vehicle, so that the instruction changes its position corresponding to the change of position of the vehicle, for a second distance traveled by the vehicle; and contact-analogue stationary displaying of the instruction at the end of the driving route, for a third distance traveled by the vehicle..
Bayerische Motoren Werke Aktiengesellschaft


07/02/15
20150184239 

Polymerases for nucleotide analogue incorporation


Compositions that include polymerases with features for improving entry of nucleotide analogues into active site regions and for coordinating with the nucleotide analogues in the active site region are provided. Methods of making the polymerases and of using the polymerases in sequencing and dna replication and amplification as well as kinetic models of polymerase activity and computer-implemented methods of using the models are also provided..
Pacific Biosciences Of California, Inc.


07/02/15
20150183847 

Protein and protein conjugate for diabetes treatment, and applications thereof


The present invention relates to the field of biopharmaceutics, and in particular to a protein, a protein conjugate, a pharmaceutical composition and its use for treating diabetes. The fusion protein of the present invention is obtained by linking two polypeptides, wherein one polypeptide is an interleukin-1 receptor antagonistic protein or an analogue thereof, and another polypeptide is glp-1 receptor binding polypeptide or an analogue thereof, or an insulin receptor binding polypeptide or an analogue thereof, or a gip receptor binding polypeptide or an analogue thereof.
Adda Biotech Inc.


07/02/15
20150183757 

Method of producing beraprost


An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds..
Lung Biotechnology Inc.


07/02/15
20150183721 

Amino-alcohol analogues and uses thereof


This invention relates to amino-alcohol analogues and uses thereof in the treatment of diseases and disorders such as cancer, neurodegenerative and metabolic diseases and genetic storage diseases.. .
Yissum Research Development Company Of The Hebrew University Of Jerusalem,


07/02/15
20150183205 

Method for optimising flexographic negatives


The invention provides an improved method of imaging analogue flexographic liquid and sheet printing plates. Specifically it involves adding colour or greyscale to some of the clear parts of negatives used to make flexographic plates.

07/02/15
20150182594 

Novel glucagon analogues


The present invention relates to novel glucagon peptides, to the use of said glucagon peptides in therapy, to methods of treatment comprising administration of said glucagon peptides to patients in need thereof, and to the use of said glucagon peptides in the manufacture of medicaments. The glucagon peptides of the present invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity..
Novo Nordisk A/s


06/25/15
20150180650 

Synchronisation for transmit and receive symbols of all-digital receiver


A synchronisation method and device for transmit and receive symbols of an all-digital receiver. The method comprises the steps of: after receiving a sampling signal sent by a baseband processing chip, the clock signal of which is provided by a second clock source, a digital signal processor (dsp), the clock signal of which is provided by a first clock source, measuring a phase shift between a local sampling symbol and an air interface symbol, and acquiring the phase shift amount; according to the phase shift amount, adjusting a sampling opportunity for the sampling of a digital-analogue/analogue-digital converter; and when the sampling opportunity for the sampling of the digital-analogue/analogue-digital converter has been adjusted, adjusting an interface clock for data transmitting and receiving of the dsp so as to enable the data transmitting and receiving of the dsp to be synchronised with the sampling..
Hytera Communications Corp., Ltd.


06/25/15
20150180496 

Phase estimator


A phase estimator comprising a first input terminal configured to receive a first analogue input signal; a second input terminal configured to receive a second analogue input signal, wherein the second analogue input signal is 90° out of phase with the first analogue input signal. The phase estimator is configured to provide a digital word representative of the phase of the first analogue input signal and the second analogue input signal.
Nxp B.v.


06/25/15
20150180495 

Converter arrangement and converting an analogue input signal into a digital output signal


The invention relates to an arrangement and a method for the identification of parameters in a nonlinear model of an analog-to-digital converter (adc 17) and the use of this information to reduce the nonlinear distortions of the adc. A parameter estimator determines an ad parameter vector pad which describes the nonlinearities of the adc (17).

06/25/15
20150175665 

Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal


There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide, pharmaceutical compositions containing said compounds, and the use of said compounds as gip-receptor agonists or antagonists for treatment of gip-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity.. .
Ipsen Pharma S.a.s.


06/25/15
20150175645 

Nicotinamide riboside and analogues thereof


Provided herein are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing.
Glaxosmithkline Llc


06/25/15
20150175587 

Synthesis of epothilones, intermediates thereto and analogues thereof


As described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (i) and provides methods of treating cancer comprising administering a compound of formula (i)..

06/25/15
20150174232 

Composition and uses thereof


An immunogenic composition comprising the nm-acp protein or an immunogenic part thereof or an analogue thereof, wherein the composition is capable of eliciting an immune response when administered to a human or non-human animal.. .
University Of Southampton


06/25/15
20150174095 

Pharmaceutical compositions for the treatment of visual system disorders


The present invention relates to pharmaceutical compositions comprising d-serine transporter inhibitors which are proline analogues and therapeutic methods using such pharmaceutical compositions in methods for the treatment of visual system disorders and the enhancement of the visual function.. .
Allergan, Inc.


06/25/15
20150173683 

System and acquisition of biopotential signals with motion artifact reduction


A biopotential signal acquisition system including an analogue readout unit configured to receive an analogue biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analogue measured biopotential signal and an analogue reference signal. The system also includes an adc unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal.
Imec Vzw


06/18/15
20150168917 

Control an analogue display fitted to a timepiece movement


In a backward direction, in accelerated mode, during a second period following the first period, before the periodic actuation wheel set is driven in a position of its area of actuation.. .

06/18/15
20150166990 

Therapeutic oligonucleotides comprising pyrazolotriazine nucleotide analogues


Disclosed herein are double-stranded rna nucleic acid molecules, which include at least one pyrazolotriazine nucleotide analogue and have been modified to exhibit one of the following, increased on-target activity, increased target specificity, enhanced nuclease stability, reduced off target activity and/or reduced immunogenicity when compared to an unmodified or similarly modified dsrna; pharmaceutical compositions comprising such molecules and methods of use thereof in therapy.. .
Qbi Enterprises Ltd.


06/18/15
20150166625 

Exendin-4 peptide analogues


The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake. .
Sanofi


06/18/15
20150166513 

Heterocyclyl pyrimidine analogues as tyk2 inhibitors


Wherein r, r1, x1 to x5 have the meaning as cited in the description and the claims. Said compounds are useful as tyk2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases.

06/18/15
20150165139 

Intranasal administration


Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.. .
Optinose As


06/18/15
20150165046 

Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators


The present invention relates to stable compositions comprising a sphingosine 1 phosphate (s1p) receptor modulator, suitable for use as a dosage form. The s1p receptor modulators are typically sphingosine analogues, such as 2-substituted 2-amino-propane-1,3-diol or 2-amino-propanol derivatives, e.g.
Novartis Ag


06/18/15
20150164998 

Insulin analogue or its pharmaceutically acceptable salt, pharmaceutical composition with prolonged therapeutic effect, use of the insulin analogue, dosage method and treatment of diabetes


The invention relates to an insulin analogue or its pharmaceutically acceptable salt, pharmaceutical composition with prolonged therapeutic effect, application of the insulin analogue, dosage method and method of treatment of diabetes. In more detail, the solution pertains to compounds being stable insulin analogues which are pharmaceutically active and characterised by a prolonged, flat, truly peakless course of glucose concentration vs.
Instytut Biotechnologii I Antybiotykow


06/18/15
20150164996 

Non-acylated exendin-4 peptide analogues


The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.. .
Sanofi


06/18/15
20150164995 

Exendin-4 peptide analogues as dual glp-1/gip agonists


The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake. .
Sanofi


06/18/15
20150164992 

Methods and compositions for promoting organ growth and development


Methods and compositions are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or foetus. Compositions and methods are also provided for the administration of at least one colony stimulating factor-1 protein (csf-1), precursor, variant, analogue, derivative thereof, or combinations thereof, or otherwise, at least one nucleic acid molecule encoding colony stimulating factor-1 protein (csf-1), precursor, variant, analogue, derivative thereof, or combinations thereof..
Kintan Pty Ltd.


06/18/15
20150164921 

Chemoprevention of colorectal cancer


In the present invention, a new combination is disclosed comprising (i) 5-aminosalicylic acid (5-asa) or a derivative thereof, or a pharmacologically acceptable salt thereof, and (ii) a group d vitamin, a derivative thereof, a metabolite or analogue, for use in the prevention and/or treatment of colorectal cancer (crc). A further aspect of the invention is directed to pharmaceutical compositions comprising said combination together with at least one physiologically acceptable excipient and the use thereof in the prevention and/or in the treatment of the colorectal cancer..
Lga Biotecnologie S.r.l.


06/18/15
20150164826 

Dosage forms and related therapies


This invention is directed in part to novel doses, dosage formulations, and routes of administration of such doses and dose formulations, said dose and dose formulations containing one or more copper chelators, for example, one or more trientine active agents, including trientine analogues, trientine salts, trientine prodrugs, and trientine derivatives, useful in the treatment of diseases, disorders and conditions, including in indications where copper may play a role.. .
Philera New Zealand Limited


06/18/15
20150164107 

Frozen dessert mixes using pulse protein products


Pulse protein products having a protein content of at least about 60 wt % (n×6.25) d.b., preferably at least about 90 wt %, and being soluble at ph values of less than about 4.4 and heat stable at such ph values, or alternatively adjusted in ph to a ph of about 6 to about 8 and further processed by drying the product, recovering and drying any precipitated pulse protein material, heat treating and then drying the product, or heat treating the product and recovering and drying any precipitated pulse protein material are used to provide, at least in part, the protein component of a dairy analogue, dairy alternative or plant/dairy blend frozen dessert mix.. .
Burcon Nutrascience (mb) Corp.


06/11/15
20150158864 

Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyr-rolo[2,3-d]pyridinyl acrylamides


The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting janus kinase (jak).
Pfizer Inc.


06/11/15
20150158841 

Curcumin analogs


Provided herein are curcumin analogues that are able to interact with amyloid β (aβ) and to attenuate the copper-induced crosslinking of aβ. Also provided herein are methods of using the compounds in the treatment of alzheimer's disease or a related disorder..
The General Hospital Corporation


06/11/15
20150157642 

Cosmetic changing the appearance of eyes


The current application is directed to cosmetic methods for changing the appearance of eyes by causing a retraction of the eyelids so that the eyes appear to be more open and have a wider appearance. Various methods involve application of one or more prostaglandins, synthetic prostaglandins, including synthetic prostaglandin f, and synthetic prostaglandin analogues, to eyelids, which results in contraction of eyelid muscles and a wider, more open appearance of the eyes..

06/11/15
20150157580 

Methods of regulating cannabinoid receptor activity-related disorders and diseases


This disclosure concerns the discovery of the use of fenoterol analogues for regulating cannabinoid (cb) receptor activity-related disorders and disease, such as dysregulated cb receptors, including treating a disorder or disease, such as a glioblastoma, hepatocellular carcinoma, liver cancer, colon cancer, and/or lung cancer, which is associated with altered cannabinoid receptor activity. In one example, the method includes administering to a subject having or at risk of developing a disorder or disease regulated by cb receptor activity an effective amount of a fenoterol analogue to reduce one or more symptoms associated with the disorder or disease regulated by cb receptor activity..
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services


06/04/15
20150153712 

Method for displaying a trend over a timing operation and associated timepiece


Portable timepiece including an hour hand and a minute hand for the current time display, rotating about a central wheel facing a bezel, and also a chronograph module, wherein the timepiece further includes a first analogue trend indicator relating to a measured time interval.. .
Eta Sa Manufacture Horlogere Suisse


06/04/15
20150153344 

Coelenterazine analogues and coelenteramide analogues


Coelenterazine analogues with different luminescence properties from conventional ones and coelenteramide analogues with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogues modified at the 8-position of coelenterazine and coelenteramide analogues modified at the 2- or 3-position of coelenteramide..
National University Corporation Tokyo Medical And Dental University


06/04/15
20150150968 

Use of cd28-specific monoclonal antibodies for producing a pharmaceutical composition for treating virus infections


The invention relates to the use of monoclonal antibodies which are specific for cd28 and activate the t lymphocytes of several up to all subgroups without the occupation of an antigen receptor of the t lymphocytes and which therefor activate said lymphocytes in an antigen unspecific manner or the invention relates to the use of an analogue thereof for producing a pharmaceutical composition in the form of a preparation or a preparation packet for treating virus infections in humans or lower warm-blooded animals having infected t lymphocytes. The pharmaceutical composition additionally contains a virus inhibitor.
Theramab Llc


06/04/15
20150150847 

Use of n-acetyl-5-methoxytryptamine or analogues thereof, for promoting the mechanism of implantation of the embryo and related compositions and culture media


The present invention refers to the use of n-acetyl-5-methoxytryptamine (melatonin) and/or an analogue thereof, for use in the medical or veterinary field in the assisted reproduction for promoting the mechanism of implantation of the embryo, and in particular for the prevention of implantation failure into the uterus, by topical administration of an effective amount in a mammalian subject female in need of such treatment, and related compositions, culture media and medical devices.. .
Ares Trading S.a.


06/04/15
20150150483 

Device, method and software for measuring exhalation capacity


Measurement device (1) for measuring the exhale capacity of a patient, includes a main body (2) with a through hole (3) with a blowing device (17) which has a rotation device (20) which is put in rotary motion through blowing, with a rotary speed depending on the intensity of the blowing, and the rotation of which is sensed by an optical sensor (6). The measuring device includes a cable (11) which is connected to the main body of the measurement device, and with a free end (11b) which is arranged to be connected to an audio input of a handheld general purpose computer unit (14), and in that the measurement device is arranged to, to the handheld computer unit, continuously deliver an analogue electric signal which carries information about rotary speed or air flow.
Pond Health Care Innovation Ab


05/28/15
20150148524 

Amino acid analogues and methods for their synthesis


A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (i) or (ii): (formulae (i), (ii)) wherein r1 and r2 are independently selected from h and substituted or unsubstituted c1 to c4 alkyl; each r3 is either absent or independently selected from a heteroatom, a substituted or unsubstituted c1 to c20 alkyl, and a substituted or unsubstituted c1 to c20 alkyl group interrupted by one or more heteroatoms; and each x is independently selected from h and an effector molecule; in the presence of a reagent to catalyse the metathesis to form a dicarba bridge between the amino acid containing a metathesisable group and the compound containing a complementary metathesisable group; and (ii) reducing the dicarba bridge to form a saturated dicarba bridge, wherein the reagent used to catalyse step (i) also catalyses step (ii).. .
Monash University


05/28/15
20150148417 

Synthesis and biological studies of an isomeric mixture of (e/z) isoxylitones and its analogues


The invention relates to an anti-epileptic isoxylitone, 2,2′-(3,5,5-trimethyl-2-cylohexen-1-ylidene)acetic acid.. .

05/21/15
20150142085 

Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues


Pharmaceutical compositions and methods for treating and/or preventing age-related macular degeneration with melatonin analogues are provided.. .
Takada Pharmaceuticals U.s.a., Inc.


05/21/15
20150141490 

Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them


The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a method for reducing gene expression in a cell comprising transfecting the cell with such an oligonucleotide.
Bio-lab Ltd.


05/21/15
20150141416 

Hydroxybupropion analogues for treating drug dependence


The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes.
Virginia Commonwealth University


05/21/15
20150141352 

Bone loss preventing and bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide


The present invention relates to a bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide, an analogue thereof, a derivative thereof or a pharmaceutically acceptable salt thereof. In contrast to existing passive therapeutic agents which center on bone absorption suppression based on mechanisms for reducing osteoclast functionality, the composition comprising muramyl dipeptide of the present invention promotes the differentiation of osteoblasts, which are bone forming cells, and can advantageously be used in various diseases where bone formation is required as an active therapeutic agent that does not affect osteoclast..
Snu R&db Foundation


05/21/15
20150141328 

Stimulation of human meibomian gland function


Disclosed herein are systems and methods for stimulating meibomian gland epithelial cell function by administering to the ocular surface or immediate vicinity of an eye of a subject an effective amount of a pharmaceutical composition containing a pld-inducing compound, such as the cationic amphiphilic drugs (e.g. Azithromycin), androgen or an androgen analogue with androgen effectiveness, corticosteroid, progesterone, igf-1 or an igf-1 analogue (e.g.
The Schepens Eye Research Institute


05/21/15
20150141255 

New strigolactone analogues and the use thereof for the treatment of plants


In which x represents o, s, nh or an n-alkyl radical, r1 and r2, identical or different, each represent h or a c1-c10 hydrocarbon radical, r1 and r2 not both representing h, r3 represents a c1-c10 hydrocarbon radical, and r represents a phenyl radical monosubstituted or disubstituted by a substituent y and, if applicable, a substituent z, chosen from cl, br, i and cf3, or r represents a c═r4(r5) radical in which r4 represents an hydrocarbon radical and r5 represents a linear or branched, saturated or unsaturated, hydrocarbon radical, optionally substituted, a cor6 group or a co2r6 group, where r6 represents a hydrogen atom or a linear or branched, saturated or unsaturated, hydrocarbon radical. This compound can be used for the treatment of higher plants for controlling their growth and architecture..

05/21/15
20150140059 

Novel oxysterol analogue, oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis


This invention relates, e.g., to a synthetic compound, oxy149, having the structure (formula i) or a bioactive or pharmaceutical composition comprising oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g.
University Louisville Research Foundation, Inc.


05/21/15
20150139553 

Device for detecting edges and improving the quality of an image


Device for edge detection and quality enhancement in an image which comprises a grouping of identical and locally interconnected elementary processing cells. Each processing cell is characterised in turn by a comparator which carries out in parallel the comparison of each pair of neighbouring pixels.
Consejo Superior De Investigaciones Cientificas


05/21/15
20150139440 

Audio interface device


A wireless interface device for at least one of wireless transmission from an electric analogue audio device or wireless reception at an electric analogue audio device of an audio signal, comprises an audio connector jack plug or jack socket in communication with a system that is at least one of a wireless internet system or a wlan-enabled system and connectable to at least one of an audio connector jack plug of the electric analogue audio device, or an audio connector jack socket of the electric analogue audio device.. .
Ingenious Audio Limited


05/14/15
20150133659 

(e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof


The present invention relates to millepachine ((e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one) and its analogues. The present invention provides methods for preparing these compounds, pharmaceutical compositions including these compounds, and methods of treating diseases utilizing pharmaceutical compositions including these compounds..

05/14/15
20150133479 

Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators


Novel compounds of structure formula i: (i) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein r1, r2 and r3 are defined herein, are provided which are gpr119 g protein-coupled receptor modulators. Gpr119 g protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring gpr119 g protein-coupled receptor modulator therapy.

05/14/15
20150133462 

Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias


In one aspect, the invention relates to compositions comprising bcr-abl tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with bcr-abl dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..

05/14/15
20150133389 

Na+/k+-atpase-specific peptide inhibitors/activators of src and src family kinases


A method for regulating src and its downstream signaling pathway which includes binding between src and na+/k+-atpase is disclosed. The na+/k+-atpase/src complex is a functional receptor for cardiotonic steroids such as ouabain.

05/14/15
20150133374 

Double-acylated glp-1 derivatives


The invention relates to a derivative of a glp-1 analogue, which analogue comprises a first k residue and a second k residue, at positions corresponding to position 26, and 37, respectively, of glp-1(7-37) (seq id no: 1), and a maximum of eight amino acid changes as compared to glp-1(7-37); which derivative comprises two protracting moieties attached to said first and second k residue, respectively, via a linker, wherein the protracting moiety is selected from chem. 1: hooc—(ch2)x—co—*, and chem.

05/14/15
20150132228 

Compositions and methods to evaluate hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions


The present invention relates to the synthesis and use of a novel trifluorinated bile acid analogue, that being, ca-sar-tfma which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analogue can be used as a 19f mri tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.. .

05/14/15
20150131649 

Content delivery system


The audio outputs 29 of each of a plurality of telecommunications terminals in a packet switched system are synchronised by having each terminal transmit a stream of packets whose rate, and therefore duration is determined according to a clock generator 25, and is thus indicative of the rate at which the terminal is generating its audio output. The signals from each terminal are transmitted to a common server.

05/14/15
20150131412 

Timepiece with display devices


A watch including a case in which there is arranged a control system, which includes a time base and is arranged to be able to perform several functions, the watch further including at least two analogue display elements and a digital display controlled independently by the control system, the watch further including a control acting on the control system. The watch is arranged in a first, normal operating mode to provide the user with a time indication by the analogue display elements driven by the control system fitted with the time base, and the watch is arranged in a second, special operating mode to allow the user to select a function via the control, to display on the digital display a value associated with the selected function, and to move an analogue display element opposite the value associated with the selected function..

05/14/15
20150130648 

Method and circuit for an analog digital capacity converter


A method for converting a capacitance of a sensing capacitor (10) to be measured into a digital signal is described, wherein according to a clocking in charging processes an integrating capacitor (5), discharged before a start of conversion, of an integrator circuit is charged by an electric current which is obtained from a charging of the sensing capacitor (10) and in discharge processes by brief current surges in the opposite direction which are obtained from a charging of a reference capacitor (6), with the result that on average no charge builds up, and the number of discharge processes occurring during a particular number of clock pulses is counted, wherein the clocking is paused after a predetermined number of cycles, a residual voltage (va1), which the integrator circuit emits due to a residual charge of the integrating capacitor (5), is converted by means of analogue-to-digital voltage conversion (25) into a digital value and the counted number of discharge processes and the particular number of clock pulses are combined with the digital value emitted by the analogue-to-digital voltage converter (25) to form a digital total result, wherein least significant bits of the total result are defined on the basis of the digital value emitted by the analogue-to-digital voltage converter (25) and most significant bits of the total result are defined on the basis of the counted number of discharge processes and the particular number of clock pulses.. .

05/14/15
20150130366 

Led driver with external temperature-compensated illumination control signal modulator


The present invention concerns led drivers and is in particular directed to signal overlay for feature addition to an existing led driver. Specifically, the invention is directed to an apparatus (200) for operating a led driver (100), to a method of operating a led driver, to a computer program for operating a led driver and to a led driver unit.

05/07/15
20150126707 

Daptomycin analogues and a the preparation of daptomycin or a daptomycin analogue


A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues.
The University Of Hong Kong


05/07/15
20150126683 

Catalyst compositions and their use for hydrogenation of nitrile rubber


This invention relates to novel catalyst compositions based on ruthenium or osmium carbene-complex catalysts, pref. Of the grubbs-i, -ii or -iii type or fluorenylidene analogues thereof, and terminal olefins, pref.
Lanxess Deutschland Gmbh


05/07/15
20150126439 

Pharmaceutical composition


A combination comprising at least a first insulin-like compound and a second insulin-like compound for treating a condition or a disease in a subject in need thereof where administration of insulin would be of benefit to said subject is described. The combination is administered in an amount to achieve a beneficial glycaemic control in said subject as determined by the levels of hba1c in said subject after administration of said combination at the largest meal of the day for said subject; wherein said beneficial glycaemic control by said combination is superior to any glycaemic control achieved by an equivalent dose of iglar in said subject as determined by the levels of hba1c in said subject after administration of iglar for said subject and/or wherein said beneficial glycaemic control by said combination comprises decreasing the levels of hba1c in said subject to about 7 or less after administration of said combination at the largest meal of the day; wherein said first insulin-like compound is longer acting than the second insulin-like compound; wherein said combination is administered at the largest meal of the day for said subject; wherein said first insulin-like compound is at least a long acting insulin, preferably an ultra long acting insulin; wherein said first insulin-like compound is a derivative of a naturally occurring insulin or is an insulin analogue; and wherein said first insulin-like compound has a side chain attached to the a-amino group of the n-terminal amino acid residue of the b chain or to the ε-amino group of a lys residue present in the b chain of the parent insulin, the side chain being of the general formula (i):—w-x-y-z..
Novo Nordisk A/s


05/07/15
20150125431 

Glucagon-like-peptide-2 (glp-2) analogues


Glp-2 analogues are disclosed which comprise one of more substitutions as compared to h[gly2]glp-2 and which may have the property of an altered glp-1 activity, and their medical use. The analogues are particularly useful for the prophylaxis, treatment or ameliorating of the gastro-intestinal associated side effects of diabetes..
Zealand Pharma A/s


05/07/15
20150125390 

18f-labelled folate/antifolate analogues


The present invention is directed towards new 18f-folate/antifolate analogue radiopharmaceuticals, wherein the phenyl group within folate structures has been replaced by an 18f-heterocycle, their precursors, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.. .
Merck & Cie


05/07/15
20150123841 

Method for search radar processing using random matrix theory


A new method for processing search radar data is revealed using the mathematics of random matrix theory. During the time that the radar receiver is listening for return target echos, the raw data stream is fed to an analogue to digital converter to create a sample voltage file.

05/07/15
20150121710 

Method of analogue measurement scanning on a machine tool


A method of building up a measurement data set for a surface of an object using an analogue measurement probe mounted on a machine tool apparatus which obtains scanned measurement data of the surface over a plurality of offset traverses. Subsequent traverses are offset from previous traverses such that over a series of traverses the analogue probe's surface detecting region progresses i) laterally across the object, and/or ii) away from or towards the object.
Renishaw Plc


04/30/15
20150119463 

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.


04/30/15
20150119462 

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.


04/30/15
20150119460 

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.


04/30/15
20150119352 

Dinuceloside polyphosphates for the treatment of pain


The invention provides a dinucleoside polyphosphate analogue, or a pharmaceutically acceptable salt thereof, for use in the inhibition (or down-regulation) of a pain, via a transducing atp-gated p2x3 receptor, often by means of high-affinity desensitisation (had) mechanism.. .
Globalacornltd.


04/30/15
20150119343 

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.
The Texas A & M University System


04/30/15
20150119259 

Nucleic acid sequencing by nanopore detection of tag molecules


This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule..
Genia Technologies, Inc.




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Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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