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Date/App# patent app List of recent Analogue-related patents
05/21/15
20150142085
 Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues patent thumbnailnew patent Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues
Pharmaceutical compositions and methods for treating and/or preventing age-related macular degeneration with melatonin analogues are provided.. .
Takada Pharmaceuticals U.s.a., Inc.
05/21/15
20150141490
 Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them patent thumbnailnew patent Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them
The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a method for reducing gene expression in a cell comprising transfecting the cell with such an oligonucleotide.
Bio-lab Ltd.
05/21/15
20150141416
 Hydroxybupropion analogues for treating drug dependence patent thumbnailnew patent Hydroxybupropion analogues for treating drug dependence
The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes.
Virginia Commonwealth University
05/21/15
20150141352
 Bone loss preventing and bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide patent thumbnailnew patent Bone loss preventing and bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide
The present invention relates to a bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide, an analogue thereof, a derivative thereof or a pharmaceutically acceptable salt thereof. In contrast to existing passive therapeutic agents which center on bone absorption suppression based on mechanisms for reducing osteoclast functionality, the composition comprising muramyl dipeptide of the present invention promotes the differentiation of osteoblasts, which are bone forming cells, and can advantageously be used in various diseases where bone formation is required as an active therapeutic agent that does not affect osteoclast..
Snu R&db Foundation
05/21/15
20150141328
 Stimulation of human meibomian gland function patent thumbnailnew patent Stimulation of human meibomian gland function
Disclosed herein are systems and methods for stimulating meibomian gland epithelial cell function by administering to the ocular surface or immediate vicinity of an eye of a subject an effective amount of a pharmaceutical composition containing a pld-inducing compound, such as the cationic amphiphilic drugs (e.g. Azithromycin), androgen or an androgen analogue with androgen effectiveness, corticosteroid, progesterone, igf-1 or an igf-1 analogue (e.g.
The Schepens Eye Research Institute
05/21/15
20150141255
 New strigolactone analogues and the use thereof for the treatment of plants patent thumbnailnew patent New strigolactone analogues and the use thereof for the treatment of plants
In which x represents o, s, nh or an n-alkyl radical, r1 and r2, identical or different, each represent h or a c1-c10 hydrocarbon radical, r1 and r2 not both representing h, r3 represents a c1-c10 hydrocarbon radical, and r represents a phenyl radical monosubstituted or disubstituted by a substituent y and, if applicable, a substituent z, chosen from cl, br, i and cf3, or r represents a c═r4(r5) radical in which r4 represents an hydrocarbon radical and r5 represents a linear or branched, saturated or unsaturated, hydrocarbon radical, optionally substituted, a cor6 group or a co2r6 group, where r6 represents a hydrogen atom or a linear or branched, saturated or unsaturated, hydrocarbon radical. This compound can be used for the treatment of higher plants for controlling their growth and architecture..
05/21/15
20150140059
 Novel oxysterol analogue, oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis patent thumbnailnew patent Novel oxysterol analogue, oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis
This invention relates, e.g., to a synthetic compound, oxy149, having the structure (formula i) or a bioactive or pharmaceutical composition comprising oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g.
University Louisville Research Foundation, Inc.
05/21/15
20150139553
 Device for detecting edges and improving the quality of an image patent thumbnailnew patent Device for detecting edges and improving the quality of an image
Device for edge detection and quality enhancement in an image which comprises a grouping of identical and locally interconnected elementary processing cells. Each processing cell is characterised in turn by a comparator which carries out in parallel the comparison of each pair of neighbouring pixels.
Consejo Superior De Investigaciones Cientificas
05/21/15
20150139440
 Audio interface device patent thumbnailnew patent Audio interface device
A wireless interface device for at least one of wireless transmission from an electric analogue audio device or wireless reception at an electric analogue audio device of an audio signal, comprises an audio connector jack plug or jack socket in communication with a system that is at least one of a wireless internet system or a wlan-enabled system and connectable to at least one of an audio connector jack plug of the electric analogue audio device, or an audio connector jack socket of the electric analogue audio device.. .
Ingenious Audio Limited
05/14/15
20150133659
 (e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof patent thumbnail(e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof
The present invention relates to millepachine ((e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one) and its analogues. The present invention provides methods for preparing these compounds, pharmaceutical compositions including these compounds, and methods of treating diseases utilizing pharmaceutical compositions including these compounds..
05/14/15
20150133479

Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators


Novel compounds of structure formula i: (i) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein r1, r2 and r3 are defined herein, are provided which are gpr119 g protein-coupled receptor modulators. Gpr119 g protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring gpr119 g protein-coupled receptor modulator therapy.
05/14/15
20150133462

Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias


In one aspect, the invention relates to compositions comprising bcr-abl tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with bcr-abl dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
05/14/15
20150133389

Na+/k+-atpase-specific peptide inhibitors/activators of src and src family kinases


A method for regulating src and its downstream signaling pathway which includes binding between src and na+/k+-atpase is disclosed. The na+/k+-atpase/src complex is a functional receptor for cardiotonic steroids such as ouabain.
05/14/15
20150133374

Double-acylated glp-1 derivatives


The invention relates to a derivative of a glp-1 analogue, which analogue comprises a first k residue and a second k residue, at positions corresponding to position 26, and 37, respectively, of glp-1(7-37) (seq id no: 1), and a maximum of eight amino acid changes as compared to glp-1(7-37); which derivative comprises two protracting moieties attached to said first and second k residue, respectively, via a linker, wherein the protracting moiety is selected from chem. 1: hooc—(ch2)x—co—*, and chem.
05/14/15
20150132228

Compositions and methods to evaluate hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions


The present invention relates to the synthesis and use of a novel trifluorinated bile acid analogue, that being, ca-sar-tfma which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analogue can be used as a 19f mri tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.. .
05/14/15
20150131649

Content delivery system


The audio outputs 29 of each of a plurality of telecommunications terminals in a packet switched system are synchronised by having each terminal transmit a stream of packets whose rate, and therefore duration is determined according to a clock generator 25, and is thus indicative of the rate at which the terminal is generating its audio output. The signals from each terminal are transmitted to a common server.
05/14/15
20150131412

Timepiece with display devices


A watch including a case in which there is arranged a control system, which includes a time base and is arranged to be able to perform several functions, the watch further including at least two analogue display elements and a digital display controlled independently by the control system, the watch further including a control acting on the control system. The watch is arranged in a first, normal operating mode to provide the user with a time indication by the analogue display elements driven by the control system fitted with the time base, and the watch is arranged in a second, special operating mode to allow the user to select a function via the control, to display on the digital display a value associated with the selected function, and to move an analogue display element opposite the value associated with the selected function..
05/14/15
20150130648

Method and circuit for an analog digital capacity converter


A method for converting a capacitance of a sensing capacitor (10) to be measured into a digital signal is described, wherein according to a clocking in charging processes an integrating capacitor (5), discharged before a start of conversion, of an integrator circuit is charged by an electric current which is obtained from a charging of the sensing capacitor (10) and in discharge processes by brief current surges in the opposite direction which are obtained from a charging of a reference capacitor (6), with the result that on average no charge builds up, and the number of discharge processes occurring during a particular number of clock pulses is counted, wherein the clocking is paused after a predetermined number of cycles, a residual voltage (va1), which the integrator circuit emits due to a residual charge of the integrating capacitor (5), is converted by means of analogue-to-digital voltage conversion (25) into a digital value and the counted number of discharge processes and the particular number of clock pulses are combined with the digital value emitted by the analogue-to-digital voltage converter (25) to form a digital total result, wherein least significant bits of the total result are defined on the basis of the digital value emitted by the analogue-to-digital voltage converter (25) and most significant bits of the total result are defined on the basis of the counted number of discharge processes and the particular number of clock pulses.. .
05/14/15
20150130366

Led driver with external temperature-compensated illumination control signal modulator


The present invention concerns led drivers and is in particular directed to signal overlay for feature addition to an existing led driver. Specifically, the invention is directed to an apparatus (200) for operating a led driver (100), to a method of operating a led driver, to a computer program for operating a led driver and to a led driver unit.
05/07/15
20150126707

Daptomycin analogues and a the preparation of daptomycin or a daptomycin analogue


A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues.
The University Of Hong Kong
05/07/15
20150126683

Catalyst compositions and their use for hydrogenation of nitrile rubber


This invention relates to novel catalyst compositions based on ruthenium or osmium carbene-complex catalysts, pref. Of the grubbs-i, -ii or -iii type or fluorenylidene analogues thereof, and terminal olefins, pref.
Lanxess Deutschland Gmbh
05/07/15
20150126439

Pharmaceutical composition


A combination comprising at least a first insulin-like compound and a second insulin-like compound for treating a condition or a disease in a subject in need thereof where administration of insulin would be of benefit to said subject is described. The combination is administered in an amount to achieve a beneficial glycaemic control in said subject as determined by the levels of hba1c in said subject after administration of said combination at the largest meal of the day for said subject; wherein said beneficial glycaemic control by said combination is superior to any glycaemic control achieved by an equivalent dose of iglar in said subject as determined by the levels of hba1c in said subject after administration of iglar for said subject and/or wherein said beneficial glycaemic control by said combination comprises decreasing the levels of hba1c in said subject to about 7 or less after administration of said combination at the largest meal of the day; wherein said first insulin-like compound is longer acting than the second insulin-like compound; wherein said combination is administered at the largest meal of the day for said subject; wherein said first insulin-like compound is at least a long acting insulin, preferably an ultra long acting insulin; wherein said first insulin-like compound is a derivative of a naturally occurring insulin or is an insulin analogue; and wherein said first insulin-like compound has a side chain attached to the a-amino group of the n-terminal amino acid residue of the b chain or to the ε-amino group of a lys residue present in the b chain of the parent insulin, the side chain being of the general formula (i):—w-x-y-z..
Novo Nordisk A/s
05/07/15
20150125431

Glucagon-like-peptide-2 (glp-2) analogues


Glp-2 analogues are disclosed which comprise one of more substitutions as compared to h[gly2]glp-2 and which may have the property of an altered glp-1 activity, and their medical use. The analogues are particularly useful for the prophylaxis, treatment or ameliorating of the gastro-intestinal associated side effects of diabetes..
Zealand Pharma A/s
05/07/15
20150125390

18f-labelled folate/antifolate analogues


The present invention is directed towards new 18f-folate/antifolate analogue radiopharmaceuticals, wherein the phenyl group within folate structures has been replaced by an 18f-heterocycle, their precursors, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.. .
Merck & Cie
05/07/15
20150123841

Method for search radar processing using random matrix theory


A new method for processing search radar data is revealed using the mathematics of random matrix theory. During the time that the radar receiver is listening for return target echos, the raw data stream is fed to an analogue to digital converter to create a sample voltage file.
05/07/15
20150121710

Method of analogue measurement scanning on a machine tool


A method of building up a measurement data set for a surface of an object using an analogue measurement probe mounted on a machine tool apparatus which obtains scanned measurement data of the surface over a plurality of offset traverses. Subsequent traverses are offset from previous traverses such that over a series of traverses the analogue probe's surface detecting region progresses i) laterally across the object, and/or ii) away from or towards the object.
Renishaw Plc
04/30/15
20150119463

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.
04/30/15
20150119462

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.
04/30/15
20150119460

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.
04/30/15
20150119352

Dinuceloside polyphosphates for the treatment of pain


The invention provides a dinucleoside polyphosphate analogue, or a pharmaceutically acceptable salt thereof, for use in the inhibition (or down-regulation) of a pain, via a transducing atp-gated p2x3 receptor, often by means of high-affinity desensitisation (had) mechanism.. .
Globalacornltd.
04/30/15
20150119343

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.
The Texas A & M University System
04/30/15
20150119259

Nucleic acid sequencing by nanopore detection of tag molecules


This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule..
Genia Technologies, Inc.
04/30/15
20150118674

Anti-hbc quantitative detection method and uses thereof in monitoring and controlling disease progression of chronic hepatitis b patient and in predicting therapeutic effect


The present invention relates to a method for quantitative detection of anti-hbc and its use in monitoring disease progression of chronic hepatitis b patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis b core protein (anti-hbc), it is able to monitor disease progression of chronic hepatitis b patients, effectively predict therapeutic effects in chronic hepatitis b patients who accept a therapy against hepatitis b virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analogue anti-hbv drug), and thus guide the patients to reasonably choose drugs..
Xiamen Innovax Biotech Co., Ltd.
04/30/15
20150118277

Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis


This invention relates, e.g., to a synthetic compound, oxy133, having the structure [formula i] or a bioactive or pharmaceutical composition comprising oxy133 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g.
The Regents Of The University Of California
04/30/15
20150118214

Pharmaceutical composition containing human cyclooxygenase and doxorubicin or doxorubicin analogue, preparation method therefor and use thereof in preparing drugs


Provided are a pharmaceutical composition containing human cyclooxygenase and doxorubicin or a doxorubicin analogue using salvia plectranthoides (also referred to as rare grass) as a crude drug, a preparation method therefor and the use thereof in preparing drugs for treating nephritis, cholecystitis and gallbladder polyps, tumours or antiphlogistic and analgesic drugs.. .
04/30/15
20150115158

Photoelectric-type continuous liquid level measurement


A photoelectric-type continuous liquid level measurement method is applied to a photoelectric-type continuous liquid level measurement device which comprises at least one sensor module formed by cascading a plurality of sensors, and comprises: driving the sensors one by one from bottom to top to take a liquid level measurement; after detecting the light intensity of a detection light returned from the position where the sensors are located, the sensors which are currently in a driving state conducting analogue-to-digital conversion on a voltage value corresponding to the detected light intensity to obtain current analogue-to-digital conversion data; according to the correlation between a preset liquid level and the analogue-to-digital conversion data, determining the liquid level of the position where the sensors are located; and summarizing to a transmitter module the liquid level measured by each of the sensors to obtain the total liquid level of a currently measured.. .
Polymer(suzhou) Sensing Technology Co., Ltd.
04/23/15
20150112247

System for gas treatment of a cell implant


System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine.
Giner, Inc.
04/23/15
20150111933

Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor


The present invention relates to deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor and their use for treating fertility disorders.. .
Merck Patent Gmbh
04/23/15
20150111921

Cortistatin analogues and syntheses therof


The present invention relates to analogs of cortistatin a, j, k, and l, having the general formula: i and salts thereof, wherein r1, r2, r3, r4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin a, j, k, and l, and analogs thereof.. .
President And Fellows Of Harvard College
04/23/15
20150111914

Spirolactam cgrp receptor antagonists


The present invention is directed to spirolactam analogues which are antagonists of cgrp receptors and useful in the treatment or prevention of diseases in which cgrp is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which cgrp is involved..
Merck Sharp & Dohme Corp.
04/23/15
20150111906

Synthetic rigidin analogues as anticancer agents, salts, solvates and prodrugs thereof, and producing same


Wherein r, r1 and r2 are selected from hydrogen, aryl, fused aryl, heteroaryl, saturated carbocylclic, partially saturated carbocyclic, saturated heterocyclic, partially saturated heterocyclic, c1-10 alkyl, haloalkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, alkenylalkyl, alkynylalkyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, nitroalkyl, cyanoalkyl, acetamidoalkyl, and acyloxyalkyl. A process for the preparation thereof is also provided..
04/23/15
20150111826

Acylated glucagon analogues


The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods.
Boehringer Ingelheim International Gmbh
04/23/15
20150111823

Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue


The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hghrelin.. .
Ipsen Pharma S.a.s.
04/23/15
20150111817

Glucagon analogues


The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods.
Boehringer Ingelheim International Gmbh
04/23/15
20150111759

Method of preparation of nanopore and uses thereof


This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule..
Government Of The United States Of America, As Represented By The Secretary Of Commerce
04/23/15
20150110818

Method for presymptomatic diagnosis of coeliac disease and gluten sensitivity


The invention relates to the use of an immunologically reactive microbial transglutaminase or its immunologically reactive parts or analogues, which are present in a complex with gliadin or its immunologically reactive parts or analogues, for the diagnosis and/or therapy control of coeliac disease or sprue as well as gluten sensitivity, and a kit for determining the diagnosis and/or therapy control of coeliac disease or sprue as well as of gluten sensitivity, by means of the previously mentioned complex.. .
Aesku.diagnostics Gmbh & Co. Kg
04/23/15
20150109890

Device for detecting and synchronising the position of a wheel of a timepiece mechanism


A device for detecting and synchronising a position of at least one first wheel of a timepiece mechanism for an electronic analogue wristwatch, includes this first wheel extending in a plane. The detection and synchronisation device includes at least one light source emitting a light beam and at least one light detection system.
The Swatch Group Research And Devlopment Ltd.
04/16/15
20150105695

Method and acquiring and processing acoustic energy emitted by at least one organ in a biological system


In some embodiments, an apparatus for acquiring, processing and transmitting physiological sounds, which may include acoustic sounds from at least one organ in a biological system, may include a sensor for acquiring physiological sounds. analogue signals representative of the physiological sounds are converted into an electrical output.
04/16/15
20150105438

Substituted isoindoline-1,3-dione derivatives


This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast.
Concert Pharmaceuticals, Inc.
04/16/15
20150105363

Methods and formulations for treating scars and beta-catenin-mediated disorders


A topical drug composition for treating a β-catenin-mediated disorder in a mammal is provided comprising a nefopam compound selected from nefopam, or a functionally equivalent analogue, prodrug, salt or solvate thereof.. .
04/16/15
20150105041

Radio repeater system


A system and/or method for facilitating wireless communication in an area where it is difficult to transmit and receive signals may use a preexisting wired emergency communication infrastructure to transmit signals between elements of a radio repeater system. Optionally, the system may include synchronization of retransmissions.
Techmer Ltd.
04/16/15
20150104102

Semantic segmentation method with second-order pooling


Feature extraction, coding and pooling, are important components on many contemporary object recognition paradigms. This method explores pooling techniques that encode the second-order statistics of local descriptors inside a region.
Universidade De Coimbra
04/16/15
20150101204

Method of finding a feature using a machine tool


A method of finding a feature of an object using an analogue probe mounted on a machine tool. The method includes the analogue probe and/or object following a course of motion which causes the analogue probe's surface sensing region to traverse across the feature to be found a plurality of times whilst approaching the feature over successive traverses so as to ultimately arrive in a position sensing relationship with the feature so as to collect scanned measurement data about the feature along at least part of a traverse..
Renishaw Plc
04/09/15
20150099787

Non-flushing niacin analogues, and methods of use thereof


One aspect of the present invention relates to substituted pyridines and pharmaceutially acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the invention relates to a pharmaceutical composition, comprising a compound of the present invention or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.
Trustees Of Tufts College
04/09/15
20150099191

Co-solvents with high coulombic efficiency in propylene carbonate based electrolytes


A homologous series of cyclic carbonate or propylene carbonate (pc) analogue solvents with increasing length of linear alkyl substitutes were synthesized and used as co-solvents with pc for graphite based lithium ion half cells. A graphite anode reaches a capacity around 310 mah/g in pc and its analogue co-solvents with 99.95% coulombic efficiency.
The Regents Of The University Of California
04/09/15
20150097711

Analogue to digital converter


An analogue to digital converter comprises an input terminal configured to receive an analogue input signal and an output terminal configured to provide an output digital signal. The analogue to digital converter also comprises a main summer having a summing input, a subtracting input and a summing output, wherein the summing input is connected to the input terminal; an analogue filter having a filter input and a filter output, wherein the filter input is connected to the summing output; a quantizer having a quantizer input and a quantizer output, wherein the quantizer input is connected to the filter output; a digital integrator having a digital integrator input and a digital integrator output, wherein the digital integrator output is configured to provide a multi-bit output signal, the digital integrator input is connected to the quantizer output, and the digital integrator output is connected to the output terminal; and a main feedback digital to analogue converter having a main feedback converter input and a main feedback converter output, wherein the main feedback converter input is connected to the digital integrator output, and the main feedback converter output is connected to the subtracting input of the main summer..
Nxp B.v.
04/02/15
20150093419

Absorption enhancers such as e.g. bht, bha or propyl gallate


The invention provides a pharmaceutical composition comprising a mixture of (a) an active macromolecular principle, and (b) an aromatic alcohol absorption enhancer chosen from butylated hydroxy toluene, butylated hydroxy anisole and analogues and derivatives thereof, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active macromolecular principle, and further comprises a pharmaceutical composition comprising a mixture of (a) an active macromolecular principle, (b) an aromatic alcohol absorption enhancer chosen from propyl gallate, butylated hydroxy toluene, butylated hydroxy anisole and analogues and derivatives thereof, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active macromolecular principle, and (c) a solubilisation aid capable of increasing the solubility of the aromatic alcohol absorption enhancer in aqueous media.. .
Axcess Limited
04/02/15
20150092897

Method and device for achieving cmmb diversity reception


A method and apparatus for achieving china mobile multimedia broadcasting (cmmb) diversity reception are disclosed. The method includes: acquiring respective analogue-to-digital converter (adc) data of two antennas; respectively conducting a synchronization and fast fourier transform (fft) operation on the adc data of the two antennas, acquiring delay information about the two antennas, and according to an operation result, selecting a signal to noise ratio (snr) configuration parameter; according to the delay information, conducting delay compensation on the operated data; and according to the selected snr configuration parameter, merging the data of the two antennas on which the delay compensation is conducted, and outputting the data.
Zte Plaza, Keji Road South
04/02/15
20150092880

Radio communication transmitter apparatus and method


A radio communication transmitter apparatus 20 is operable to transmit multiple radio frequency bands in a telecommunication system. The apparatus comprises a plurality of digital transmitter chains 211 to 21n, wherein each digital transmitter chain is coupled to receive a digital representation 271 to 27n of a respective base band signal for processing by a respective digital transmitter chain.
Telefonaktiebolaget L M Ericsson (publ)
04/02/15
20150092827

Method for determining the imperfections of a transmit pathway and of a receive pathway of an apparatus, and associated radio apparatus


A method is provided for determining the imperfections of a transmit pathway and of a receive pathway of an apparatus, and associated radio apparatus, the transmit pathway comprising a first device for frequency transposition of an analogue sequence to an analogue signal, using a first transposition frequency, the receive pathway comprising a second device for frequency transposition of an analogue signal to an analogue sequence, using a second transposition frequency different from the first transposition frequency.. .
Thales
03/26/15
20150087838

Process for the preparation of radioiodinated 3-fluoropropyl-nor-beta-cit


The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor-β-cit. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor-β-cit from anhydroecgonine methyl ester.
Mallinckrodt Llc
03/26/15
20150087594

Induced neural stem cells


The present invention relates to a method of deriving an induced neural stem cell (incs) by nuclear reprogramming of a somatic cell, wherein the method comprises a step of contacting the somatic cell with oct4 protein or a functionally equivalent analogue, variant or fragment thereof for a limited time period, as well as an induced neural stem cell obtained by this method.. .
Merck Patent Gmbh
03/26/15
20150087588

Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors


The present invention relates to a combination which comprises (a) a somatostatin analogue and (b) a 11beta-hydroxylase inhibitor; each in free form or in the form of a pharmaceutical acceptable salt thereof; the use of such a combination for the preparation of a medicament for the treatment of diseases associated with increased stress hormone levels; a commercial package or product comprising such a combination; and to a method of treatment of a warm-blooded animal, especially a human.. .
Novatis Ag
03/26/15
20150087587

Process for the synchronization of ovulation for timed breeding without heat detection


A method for synchronizing ovulation in sows and gilts by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (gnrh), luteinizing hormone (lh), follicle stimulating hormone (fsh), human chorionic gonadotropin (hcg), analogues, derivatives, agonists or combinations thereof is administered to an open sow post weaning at a specific time to stimulate ovulation of mature responsive follicles.
Thorn Bioscience Llc
03/26/15
20150087033

Methods for making tocoflexols and analogues thereof


Methods for the synthesis of tocoflexols of formula (i) and (ii) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material..
The United States Of America As Represented By The Department Of Veterans Affairs
03/26/15
20150084799

Multi-level quantizers and analogue-to-digital converters


An analogue-to-digital converter employs one or more reference ladders for generating reference voltages with which to compare the analogue signal for quantization. Selected impedances of the reference ladder can be dynamically decoupled from the input signal in dependence on the value of the output signal in order to reduce headroom in the reference ladders, thus making possible accurate quantization in low-voltage applications..
Cambridge Silicon Radio Limited
03/26/15
20150083589

Bio sensing device


The present invention relates to a bio sensing device having a reaction part and a measuring device which are integrated therein. The bio sensing device includes: a main substrate, a reaction part, a signal processing part, a screen display part, and a housing.
Ceragemmedisys Inc.
03/19/15
20150080461

Composition having antiviral activity against flavivirus


The present invention relates to a composition having antiviral activity for prophylaxis or treatment of flavivirus infection or a disease resulting therefrom in humans or animals, characterised in that the composition comprises quercetin, or analogues, or derivatives thereof. The composition may further comprise a pharmaceutically acceptable carrier.
University Malaya
03/19/15
20150080340

Boronic acid conjugates of oligonucleotide analogues


Oligonucleotide analogues comprising boronic acid and/or boronic ester moieties are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..
Sarepta Therapeutics, Inc.
03/19/15
20150080312

Hexadepsipeptide analogues as anticancer compounds


Or derivatives or pharmaceutically acceptable salts thereof. The invention also includes all isomeric and tautomeric forms of the compound of formula (1) or the derivatives thereof.
03/19/15
20150080305

Application of initial doses of lhrh analogues and maintenance doses of lhrh antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits


Lhrh analogues and lhrh antagonists for use in the treatment or prophylaxis of hormone-dependent cancers, in particular prostate cancer, prostate carcinoma and/or advanced prostate carcinoma, by administering an initial dose of an lhrh analogue over a first period sufficient to effect hormonal castration, then administering a maintenance dose of an lhrh antagonist over a second period, the dose being insufficient to achieve and/or maintain hormonal castration.. .
Aeterna Zentaris Gmbh
03/19/15
20150080295

Glucagon analogues


The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods.
Zealand Pharma A/s


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Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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