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This page is updated frequently with new Analogue-related patent applications.




Date/App# patent app List of recent Analogue-related patents
05/19/16
20160142809 
 Wiring structure for electroacoustic transducer for digital signal and headphone for digital signal patent thumbnailnew patent Wiring structure for electroacoustic transducer for digital signal and headphone for digital signal
A wiring structure is provided for an electroacoustic transducer directly converting digital signals from a single sound source to sound waves without conversion to analogue signals. The structure includes a diaphragm, and a plurality of voice coils fixed to the diaphragm.
Kabushiki Kaisha Audio-technica


05/19/16
20160142461 
 Method and device for transmission of multimedia data patent thumbnailnew patent Method and device for transmission of multimedia data
The present disclosure discloses a method for transmission of multimedia data, which includes: converting analogue multimedia data received from a terminal to digital multimedia data; separating the digital multimedia data into digital audio data and digital video data, and converting coding format of the digital video data; compressing the digital audio data and the digital video data in converted thecoding format respectively, converting protocol format of the compressed digital audio data and of the compressed digital video data respectively, and sending the resulting digital audio data and the resulting digital video data to a network. The present disclosure further discloses a device for transmission of multimedia data.
Zte Corporation


05/19/16
20160142097 
 Energy-efficient system for distant measurement of analogue signals patent thumbnailnew patent Energy-efficient system for distant measurement of analogue signals
An energy-efficient system for measurement of analogue signals including one or more measuring units. Each measuring unit has a measuring probe which signal is processed by a modulator.
Elektrotehnicki Fakultet Sveucilista U Osijeku


05/19/16
20160139129 
 Biomarkers for the diagnosis and the response to treatment of pancreatic cancer patent thumbnailnew patent Biomarkers for the diagnosis and the response to treatment of pancreatic cancer
The invention related to biomarkers, a method and a kit for early diagnosis of pancreatic cancer, in particular of pancreatic ductal adenocarcinoma (pdac); and to biomarkers, a method and a kit or device for predicting or prognosticating an individual's response to combination treatment with a nucleoside analogue (preferably gemcitabine) and with a growth factor receptor (preferably erlotinib) in patients with pancreatic ductal adenocarcinoma.. .
Universidad De JaÉn


05/19/16
20160139018 
 Flat panel test hardware and technology for assessing ballistic performance of helmet personnel protective equipment patent thumbnailnew patent Flat panel test hardware and technology for assessing ballistic performance of helmet personnel protective equipment
A testing apparatus to assess ballistic performance of helmet personnel protective equipment having a flat helmet analogue with a helmet shell material in flat panel form and at least one helmet suspension pad; head surrogate components including a skull skin surrogate, a skull bone surrogate, and a brain tissue surrogate; a pressure indicating film adjacent to the head surrogate components; and one or more pressure sensors in the brain tissue surrogate. Also disclosed is the related method for assessing ballistic performance of helmet personnel protective equipment..

05/19/16
20160137712 
 Fusion proteins with dual receptor agonist activities patent thumbnailnew patent Fusion proteins with dual receptor agonist activities
The present disclosure relates to heterodimeric fusion proteins comprising two polypeptides, the first polypeptide comprising a first peptide (p1), a linker (l1), and a fc region (f1), the second polypeptide comprising a second peptide (p2), a linker (l2), and an fc region (f2), wherein p1 and p2 are each independently selected from glp-1, glp-1 analogues, glucagon, glucacon analogues, gip, gip analogues, oxyntomodulin, oxyntomodulin analogues, exendin and exendin analogues; wherein f is selected from an igg fc, an iga fc, an ige fc, an iggm fc, and their analogues; wherein the c-terminals of the peptides are linked, though the linker l, to the n-terminals of the fc region f. In one embodiment, the fusion proteins disclosed herein have agonist activity against at least two of the glp-1 receptor, the gip receptor, and the glucagon receptor..
Askgene Pharma, Inc.


05/19/16
20160136267 
 Sphingoglycolipid analogues patent thumbnailnew patent Sphingoglycolipid analogues
The invention relates to sphingoglycolipid analogues which are useful in treating or preventing diseases and conditions such as those relating to infection, atopic disorders, autoimmune diseases or cancer.. .
Victoria Link Limited


05/19/16
20160136233 
 Novel cyclosporin analogues for preventing or treating hepatitis c infection patent thumbnailnew patent Novel cyclosporin analogues for preventing or treating hepatitis c infection
The present invention relates to novel cyclosporine analogues having antiviral activity against hcv and useful in the treatment of hcv infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds..
Enanta Pharmaceuticals, Inc.


05/12/16
20160134705 
 Digital sensor for a can network of a vehicle patent thumbnailDigital sensor for a can network of a vehicle
Digital sensor for a can network of a vehicle, comprising a casing (4) which comprises a first portion (56) provided with a housing (60) capable of receiving a first electrical cable (8) and a second electrical cable (10), said first portion (56) receiving a first electrical component (24) and a second electrical component (26) respectively arranged opposite said housing (60), and which first electrical component (24) and second electrical component (26) each have a substantially flat surface adapted to constitute a capacitive element with respectively a portion (14) of said first electrical cable (8) and a portion (16) of said second electrical cable (10), such that, when said first electrical cable (8) and said second electrical cable (10) are received in said housing (60) and each carry a respective can digital signal, said first electrical component (24) and said second electrical component (26) carry an electrical signal corresponding to the digital can signal respectively carried on said first electrical cable (8) and on said second electrical cable (10), and a second portion (58) receiving an electronic circuitry (6) connected to said first electrical component (24) and said second electrical component (26), and arranged on the one hand to process the electrical signals which they carry in order to rebuild a first analogue signal and a second analogue signal which reflect the digital can signal respectively carried by the first electrical cable (8) and the second electrical cable (10), and on the other hand to transform the first analogue signal and the second analogue signal into respective digital can signals towards an output (12) connected to said electronic circuitry (6).. .
Masternaut Holdings Limited


05/12/16
20160134290 
 Gray counter and analogue-digital converter using such a counter patent thumbnailGray counter and analogue-digital converter using such a counter
An n-bit gray counter, with n an integer greater than 1, comprises a string of n logic cells connected in cascade, wherein each logic cell comprises an input port for a succession of clock pulses, a circuit for generating a gray count bit having an output port for the gray count bit and a circuit for generating a clock signal having a clock output port linked to the input port of the following logic cell. An analogue-digital converter of ramp type using such a gray counter is also provided..
Pyxalis


05/12/16
20160130647 

Signal confinement sequencing (scs) and nucleotide analogues for signal confinement sequencing


Novel fluorescent nucleotide analogues are provided herein. Also provided herein are methods of using the nucleotide analogues in sequencing-by-synthesis and signal confinement methods..
Complete Genomics, Inc.


05/12/16
20160130644 

Thiolated nucleotide analogues for nucleic acid synthesis


The present disclosure provide systems, compositions, methods, reagents, kits and products for extending a nucleic acid that includes incorporating a nucleotide residue at a terminus of a nucleic acid using a polymerase enzyme and at least one nucleotide, wherein the at least one nucleotide includes a thiophosphate moiety, and wherein the at least one nucleotide is resistant to hydrolysis by phosphatase. In some embodiments, the nucleotide incorporation can be conducted in the presence of a phosphatase.
Life Technologies Corporation


05/12/16
20160130304 

Novel cyclosporin analogues for preventing or treating hepatitis c infection


The present invention relates to novel cyclosporine analogues having antiviral activity against hcv and useful in the treatment of hcv infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds..
Enanta Pharmaceuticals, Inc.


05/12/16
20160130296 

Oligonucleotide analogues incorporating 5-aza-cytosine therein


Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2′-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (dpg and gpd) are provided to target the cpg islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation.
Astex Pharmaceuticals, Inc.


05/12/16
20160129139 

Method for purification of 18f-labeled choline analogues


The present invention relates to a method for purification of 18f-labeled choline analogues in a solution injectable to a patient, prepared using non-gaseous synthesis paths, comprising a step of solid phase extraction (spe) purification using a solid support, wherein the solid support used in the solid phase extraction purification has the characteristic to retain impurities and reagents from the solution but not the 18f-labeled choline analogues.. .
Trasis S.a.


05/12/16
20160129083 

Mic-1 fusion proteins and uses thereof


The invention relates to mic-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a mic-1 protein or an analogue thereof at the c-terminus of the fusion protein and a functional variant of human serum albumin at the n-terminus of the fusion protein connected via a peptide linker.
Novo Nordisk A/s


05/12/16
20160128958 

Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma


Therapeutic methods relating to the use of gaba-at inhibitor compounds for the treatment of hepatocellular carcinoma.. .

05/12/16
20160128953 

Trans-clomiphene and its analogues as agents that increase bone mineral density


The present invention relates to the administration of compositions comprising trans-clomiphene or an analogue or salt thereof, for inhibiting bone resorption and bone turnover in a subject. The invention is also directed to methods for increasing bone mineral density in a subject and preventing or treating a bone related disorder in a subject comprising administering to the subject an effective amount of trans-clomiphene or an analogue or salt thereof..
Repros Therapeutics Inc.


05/05/16
20160126968 

Analogue-to-digital converter


This application relates to analogue-to-digital converters (adcs). An adc 200 has a first converter (201) for receiving an analogue input signal (ain) and outputting a time encode signal (dt), such as a pulse-width-modulated (pwm) signal, based on input signal and a first conversion gain setting (gin).
Cirrus Logic International Semiconductor Ltd.


05/05/16
20160123850 

Method of forming a stain assessment target


A method is provided of forming a stain assessment target for a biological material staining system. At least one region of a substrate is provided upon a support such as a microscope slide.
Ffei Limited


05/05/16
20160122403 

Ghrelin splice variant for treating neuronal damage,neurodegenerative disease, parkinsons disease, alzheimers disease, and/or depression


The present disclosure relates, in one aspect, to use of ghrelin splice variant or an analogue thereof, or a ghrelin splice variant-like compound for the preparation of a medicament for one or more of: treatment and/or prevention of neuronal damage and/or neurodegeneration and, prophylaxis or treatment of neuronal damage and/or neurodegenerative disease, parkinson's disease, alzheimer's disease, depression stimulation of neuronal activity. A further aspect relates to a number of new ghrelin splice variant-like compounds and uses thereof, as well as to pharmaceutical compositions and medical packaging comprising the new ghrelin splice variant-like compounds..

05/05/16
20160122303 

Biocatalyzed synthesis of the optically pure (r) and (s) 3-methyl-1,2,3,4-tetrahydroquinoline and their use as chiral synthons for the preparation of the antithrombic (21r)- and (21s)-argatroban


The present invention relates to the biocatalyzed synthesis of enantiomerically pure (3r) and (3s)-methyl-1,2,3,4-tetrahydroquinoline. Said enantiomerically pure compounds are useful as chiral synthons in organic synthesis and, in particular, for the preparation of diastereomerically pure (21r) and (21s)-agratroban and its analogues.
Euticals S.p.a.


05/05/16
20160120971 

Immunogenic composition comprising neisseria meningitidis macrophage infectivity potentiator protein and methods for using them


An immunogenic composition comprising the nm-mip protein or an immunogenic part thereof or an analogue thereof, wherein the composition is capable of eliciting an immune response when administered to a human or non-human animal, and uses thereof. A pharmaceutical composition or a vaccine composition comprising the nm-mip protein or an immunogenic part thereof or an analogue thereof..
University Of Southampton


05/05/16
20160120951 

Acylated glucagon analogues


The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes and associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods.
Zealand Pharma A/s


05/05/16
20160120883 

Anti-infective hydroxy-phenyl-benzoates and methods of use


The invention provides a method for preventing or treating a disease caused by an extracellular microorganism, said method comprising systemically administering to a subject in need thereof a prophylactically or therapeutically effective amount of a salicylic acid (sal) or a sal analogue. The extracellular microorganism can be of the bacterial genus staphylococcus, for example, staphylococcus aureus.
Los Angeles Biomedical Research Institute At Harbor-ucla Medical Center


05/05/16
20160120857 

Anti-fibrogenic compounds, methods and uses thereof


Presented herein are methods for treatment of diseases or conditions related to fibrosis. Compounds, or pharmaceutically acceptable salts thereof or pharmaceutical compositions thereof provide for the treatment of diseases or conditions related to fibrosis.
The University Of British Columbia


05/05/16
20160120853 

Tacrolimus and analogues thereof for medical use


The present invention relates to a method of treating adverse fat accumulation and related conditions with very low doses of tacrolimus or a close structural analogue thereof. In particular this invention relates to treating adverse fat accumulation and/or sarcopenia and/or metabolic syndrome inpatients by administering tacrolimus in very low dose.
Chronos Therapeutics Limited


04/28/16
20160115216 

Method for making mature insulin polypeptides


This invention relates to an improved method for making mature human insulin or an analogue thereof by cultivating fungi cell comprising a dna sequence encoding a precursor for human insulin or an analogue thereof, which precursor comprises a small connecting peptide.. .
Novo Nordisk A/s


04/28/16
20160115179 

Spiro-oxazines, indolinones and preparation thereof


The present invention relates to novel spiro-oxazine analogues of formula-i and indolinone compounds of formula-ii or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-i formula-ii further the invention provides transition-metal free multicomponent reaction (mcr) process for the preparation of said compounds of formula-i and ii using aryne precursor, n-substituted isatin and n-heteroaromatic compound as the nucleophile, under mild condition leading to formation of desired complex of spiro-oxazine analogues (i) and indolinone analogues (ii) in high yield and selectivity..
Council Of Scientific & Industrial Research


04/28/16
20160115173 

Methods and compositions for studying, imaging, and treating pain


In embodiments, the present disclosure provides a method for alleviating pain in a subject in need of treatment, the method comprising administering to the subject an effective amount of a saxitoxin analogue compound, or a pharmaceutically acceptable salt, isomer, tautomer or prodrug thereof, whereby pain in said subject is alleviated.. .

04/28/16
20160115112 

Novel n-3 immunoresolvents: structures and actions


The invention describes novel mono-hydroxy, di-hydroxy and tri-hydroxy docosapentaenoic acid (dpa) analogues, their preparation, isolation, identification, purification and uses thereof. Resolution of inflammation is now held to be an active process where autacoids promote homeostasis.
The Brigham & Women's Hospital Inc.


04/21/16
20160112796 

Analogue signal processing circuit for microphone


An analog signal processing circuit of a microphone includes a bias circuit including a first sub-circuit which receives a signal from the microphone to output a first signal and a second sub-circuit which receives a reference voltage to output a second signal. A fully differential circuit receives the first signal and the second signal to output a fully differential signal.

04/21/16
20160107977 

Methods of synthesis of ingenol and intermediates thereof


The present invention relates generally to methods of synthesis of diterpene heterocylic compounds. More particularly, the present invention relates to efficient methods of synthesis of ingenol (formula (21), cas 30220-46-3), from a compound of formula (1).

04/21/16
20160106768 

Lysophospholipids and lysophospholipid analogues against honeybee brood diseases


The present invention refers to a compound selected from the group consisting of a lysophospholipid and a lysophospholipid analogue for use in the treatment or prophylaxis of honeybee brood diseases, in particular american foulbrood and european foulbrood. The invention also refers to a diet composition, a sprayable composition, a dipping solution for brood combs, a beeswax composition and liposomal and microsphere- or nanosphere-based compositions, comprising a compound according to the invention, for use in the treatment or prophylaxis of bee brood diseases..

04/14/16
20160104404 

Detection circuit and a liquid crystal display


A detection circuit and a detection method for liquid crystal display are provided. The detection circuit comprises a gate driver for providing row scan signal to liquid crystal cell to be detected; a signal source for providing polarity inversion signal to source driver; a source driver for performing digital-analogue conversion on received display data signal according to preset reference voltage and polarity inversion signal, generating pixel voltage signal, and sending pixel voltage signal to liquid crystal cell to be detected.

04/14/16
20160103527 

Identification and data interchange system having a portable capacitive device and a capacitive touch screen


The general field of the invention is that of systems having a capacitive touch screen. The system according to the invention has a portable capacitive device that is intended, in operational mode, to be carried by a user.

04/14/16
20160102307 

Oligonucleotide analogues targeting human lmna


Provided are lmna-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced lmna mrna isoforms that encode progerin.. .

04/14/16
20160102126 

Novel peptides involved in energy homeostasis


The expression of a mrna encoding a putative 76 amino acid, secreted protein (“enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of enho1 mrna in two mouse models of obesity, kk-ay and lepob/lepob mice.

04/14/16
20160101158 

Peptide therapeutics and methods for using same


Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of glp-1, and/or naturally or artificially occurring variants or analogues of glp-1, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as d-arg-2′6′-dmt-lys-phe-nh2).. .

03/31/16
20160094927 

Headphone device


The invention provides an apparatus that allows the user or a third party to easily monitor the volume levels of a set of headphones before and during use so as to prevent damage to the anatomy of the user's ears as a result of exposure to excessive noise volume. An analogue meter indicative of the signal level being input to or reproduced by the transducer within one or both of the headphone cans is provided, built into the outer surface of the headphone can so that it is easily visible to a user who is about to put on the headphones, or to a third party viewing the user wearing the headphones.
Ashdown Design & Marketing Limited


03/31/16
20160090621 

Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis


This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.. .
The Trustees Of Columbia University In The City Of New York


03/31/16
20160090579 

Modified polymerases for improved incorporation of nucleotide analogues


Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.. .
Illumina, Inc.


03/24/16
20160087614 

System for generating an analogue signal


The system has: a set of at least two electric current generators, at least one capacitor and activation/deactivation devices for the electric current generators; the electric current generator being connected in parallel with one another and the capacitor being connected in series with the electric current generators, the activation/deactivation devices controlling the generators by a digital stream allowing control of the intensity of the electric current entering the capacitor and generating a trapezoidal voltage signal at the terminals of the capacitor, the analog signal being reconstructed through interpolation of the trapezoidal signal.. .
Atlantic Innovation Electronic Solutions


03/24/16
20160084703 

Detection of radiation quanta using an optical detector pixel array and pixel cell trigger state sensing circuits


The invention relates to a radiation detection device for integrating the number of optical photons in a light pulse. A system, a method and a computer program product are also disclosed.
Koninklijke Philips N.v.


03/24/16
20160084073 

High temperature downhole gauge system


A gauge system and method for monitoring well pressure at temperatures in excess of 300° c. Used in permanent monitoring of oil and gas wellbores.
Zenith Oilfield Technology Limited


03/24/16
20160083448 

Site 2 insulin analogues


An insulin analogue contains one or more modifications at a distinct protein surface comprising one or more of the residues at position b13, b17, a12, a13, and/or a17. Formulations of the above analogues at successive strengths u-100 to u-1000 in soluble solutions a at least ph value in the range 6.8-8.0 either in the presence of zinc ions at a molar ratio of 2.2-10 zinc ions per six insulin analogue monomers or in the presence of fewer than 1 zinc ions per six insulin analogue monomers.
Case Western Reserve University


03/24/16
20160083447 

Double-acylated glp-1 derivatives


The invention relates to a derivative of a glp-1 analogue, which analogue comprises a first k residue at a position corresponding to position 27 of glp-1(7-37) (seq id no: 1); a second k residue at a position corresponding to position t of glp-1(7-37), where t is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to glp-1(7-37); wherein the first k residue is designated k27, and the second k residue is designated kt; which derivative comprises two albumin binding moieties attached to k27 and kt, respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from hooc—(ch2)x—co— and hooc—c6h4—o—(ch2)y—co—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —nh—(ch2)2—(o—(ch2)2)k(ch2)n—co—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel glp-1 analogues.
Novo Nordisk A/s


03/17/16
20160078255 

Method and device for reading rfid/uhf label based on audio interface


A method and a device for reading rfid/uhf label based on an audio interface are disclosed. According to the method, a built-in software module in an electronic device converts a first digital signal into an analogue signal capable of being transmitted via the audio interface; the analogue signal received by the audio interface is converted into a second digital signal via an audio communication circuit; then the rfid/uhf controller for digital signal control reads information from the rfid/uhf label; the rfid/uhf controller modulates and sends signals of a plurality of different frequency points, and the signal of every frequency point forms a signal channel.
Xiamen Innov Electronics Tech Co., Ltd.


03/17/16
20160077175 

Magnetic resonance imaging apparatus


According to one embodiment, an mri apparatus includes a bed, a digital processing circuit, a first antenna, first radio communication circuitry, a second antenna, second radio communication circuitry, and an image reconstruction circuit. An object is loaded on the bed.
Kabushiki Kaisha Toshiba


03/17/16
20160077042 

Phosphate sensor, its use and its preparation


A phosphate sensor employs a membrane which comprises a molecularly imprinted polymer produced from a thiourea derivative as functional monomer and a phosphate analogue (e.g. Phenylphosphonic acid) as template.
Yorkshire Water Services Limited


03/17/16
20160076070 

Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients


And wherein said nas are active as pharmaceutically relevant antivirals and anticancer medicaments, intermediates or prodrugs thereof.. .

03/17/16
20160075750 

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.

03/17/16
20160075741 

Cyclosporine analogue mixtures and their use as immunomodulating agents


The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine a. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives.
Aurinia Pharmaceuticals Inc.


03/17/16
20160075652 

Synthetic analogues of xanthohumol


The present invention relates to novel synthetic analogues of xanthohumol and the use thereof.. .
Azienda Ospedaliera Arcispedale Santa Maria Nouva / Irccs Istituto In Tecnologie Avanzate E Modelli


03/17/16
20160074469 

Alpha-and gamma-msh analogues


The present invention provides peptide analogues of α-msh and γ-msh, comprising the amino acid sequence of human α-msh or γ-msh, or variants thereof, and having a branched amino acid probe in the n-terminal part of the peptide.. .
Txp Pharma Gmbh


03/17/16
20160074355 

Methods of treating sickle cell disease and related disorders using fumaric acid esters


Methods of using one or more fumaric acid esters or pharmacologically active salts, derivatives, analogues, or prodrugs thereof to increase expression of fetal hemoglobin (hbf) are disclosed. The methods typically include administering to a subject an effective amount of one or more fumaric acid esters optionally in combination or alternation with hydroxyurea to induce hbf expression in the subject in an effective amount to reduce one or more symptoms of a sickle cell disorder, a hemoglobinopathy, or a beta-thalassemia, or to compensate for a genetic mutation is the human beta-globin gene (hbb) or an expression control sequence thereof.
Georgia Regents Research Institute, Inc.


03/17/16
20160074346 

Method of viral inhibition


This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, west nile virus or japanese encephalitis virus or infections caused by chikungunya virus (chikv). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with chikv, or to those who are at risk of becoming infected with a flavivirus or becoming infected with chikv..
Monash University


03/10/16
20160068809 

Use of zeburaline for the treatment of autoimmune diseases or immune rejection of transplants


The invention relates to the use of 1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one derivative or mimetic or an analogue, derivatives, metabolites, variants or salts thereof for the manufacturing of a medicament to increase the amount of indoleamine 2,3-dioxygenase (ido) production in order to induce immunological tolerance as well as a method of treating a mammal in need thereof.. .
Idogen Ab


03/10/16
20160068579 

Trap 63


The present invention for the first time discloses a novel small molecular weight enamel matrix polypeptide which is at least 80%, such as 90% identical to the amino acid sequence as shown in seq id no: 1 (mplpphpghp gyinfsyevl tplkwyqnmi rhpytsygye pmggwlhhqi ipwsqqtpq sha) (trap63), a homologue, analogue, or a pharmaceutically acceptable salt thereof. The present invention further discloses a pharmaceutical composition consisting of an enamel matrix polypeptide which is at least 80%, such as 90% identical to the amino acid sequence as shown in seq id no: 1, a homologue, analogue, or a pharmaceutically acceptable salt thereof, and a suitable pharmaceutical carrier, which further can consist of one or more enamel matrix polypeptides selected from the group of enamel matrix polypeptides which correspond to: a.
Straumann Holding Ag


03/10/16
20160068527 

The treatment of inflammatory disorders


The present invention provides nalidixic acid and analogues of nalidixic acid, and methods for treating inflammatory disorders. The nalidixic acid and analogues of nalidixic acid may be formulated for topical delivery or systemic delivery.
Cresset Biomolecular Discovery Ltd.


03/03/16
20160061900 

Method and device for measuring a dc voltage such as the voltage of a motor vehicle battery


A method for measuring a dc voltage such as the voltage vbat of a motor vehicle battery, according to which the voltage vbat is converted into a digital value nbat by an analog-to-digital converter (3) with which a reference voltage vref is associated. A standard voltage vo coming from a standard voltage source (11) is, furthermore, delivered regularly to the analogue-to-digital converter, and the voltage vo is converted into a digital value nvo, then a digital value ncor representing the value of the voltage vbat is computed, such that ncor=co×(nbat/nvo), where co=ncor_max×(2n/vbat_max)×(vo/vref), ncor_max being a value selected for coding the maximum value of ncor, nbat_max a digital value resulting from the conversion of the maximum voltage vbat_max to be measured, and n the number of bits of the analog-to-digital converter..
Continental Automotive Gmbh


03/03/16
20160061891 

Mixed mode integrated circuit, providing a controllable test clock signal to a sub-circuitry of the mixed-mode integrated circuit and detecting current paths causing violations of electromagnetic compatibility standards in the mixed mode integrated circuit


A mixed mode integrated circuit, a method of providing a controllable test clock signal to a sub-circuitry of the mixed-mode integrated circuit and a method of detecting current paths causing violations of electromagnetic compatibility standards in the mixed mode integrated circuit are provided. The mixed mode integrated circuit 100 comprises in addition to a clock network 110 an integrated test clock signal generator 140 to generate test clock signals that are provided via controllable multiplexers 150, 160 to an analogue and digital sub-circuitry, respectively, of the mixed-mode integrated circuit.
Freescale Semiconductor, Inc.


03/03/16
20160061867 

Method and metering a voltage signal


A voltage metering module for metering a voltage signal at least one analogue to digital converter (adc) component arranged to receive at an input thereof a voltage signal and to generate a digital signal representative of the received voltage signal. The at least one adc component includes at least one sampling network controllable to sample the received voltage signal for conversion to a digital signal representative of the received voltage signal and at least one compensation network operably coupled in parallel with the sampling network and controllable to sample the received voltage signal such that an input current of the compensation network at least partially compensates for a component of an input current of the sampling network..
Freescale Semiconductor, Inc.


03/03/16
20160060627 

Pharmaceutical composition for inhibition of disease-inducing micrornas


The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human micrornas. The short oligonucleotides are particularly effective at alleviating mirna repression in vivo.
Roche Innovation Center Copenhagen A/s


03/03/16
20160058683 

Hair-straightening compositions and methods


A hair-straightening complex consisting essentially of (i) at least one glyoxyloyl derivative formed by reacting glyoxylic acid with at least one alpha, beta or gamma amino acid and/or an amino acid analogue, where the amino acid, or analogue thereof, is not derived from an animal source, (ii) at least one organic acid, (iii) optionally, at least one humectant, and (iv) at least one monoalkyl or dialkyl ether of sorbitol or 1,4-dianhydrosorbitol. A method of straightening hair comprising the steps of applying the above hair-straightening complex to the hair and applying a force generally perpendicular to the length of the hair using a flat surface heated at a temperature of from about 380° f.
Cosphatech Llc


02/25/16
20160056869 

Method and device for sending user-specific reference signal


Disclosed are a method and device for sending a user-specific reference signal. The method provided in the present invention includes: determining a modulus identification, and performing interference elimination processing on a user-specific reference signal according to the modulus identification to obtain the user-specific reference signal after the interference elimination processing; performing beamforming processing on the user-specific reference signal after the interference elimination processing to obtain a beamforming reference signal; and performing inverse fast fourier transform (ifft) and digital-analogue conversion on the beamforming reference signal to obtain an analogue signal of the user-specific reference signal, and sending the analogue signal to a user terminal..
Huawei Technologies Co., Ltd.


02/25/16
20160052873 

Novel intermediate used for preparing tapentadol or analogues thereof


The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula i or ii, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof.
Anhui New Star Pharmaceutical Development Co., Ltd


02/25/16
20160052866 

Novel intermediate used for preparing tapentadol or analogues thereof


The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula i or ii, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof.
Anhui New Star Pharmaceutical Development Co., Ltd.


02/25/16
20160051625 

Cyclosporin analogues for preventing or treating hepatitis c infection


The present invention relates to cyclosporin analogues having antiviral activity against hcv and useful in the treatment of hcv infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds..
Enanta Pharmaceuticals, Inc.


02/25/16
20160051526 

The local treatment of inflammatory ophthalmic disorders


The present invention provides nalidixic acid and analogues of nalidixic acid, pharmaceutical compositions including at least one of nalidixic acid and analogues of nalidixic acid, and methods for treating inflammatory ophthalmic disorders by local administration. The ophthalmic disorders may be characterized by ocular inflammation, dry eye disorders, pathological ocular angiogenesis, or retinal or sub-retinal edema..
Cresset Biomolecular Discovery Ltd


02/18/16
20160047916 

Automated methods for suppression of spurious signals


An automated method is provided for suppressing spurious signals in a direct digital synthesized signal. To determine magnitudes of local oscillator (“lo”) feedthrough and image frequency signal components, a digitally synthesized rf signal is digitally analyzed.
Spirent Communications Plc


02/18/16
20160045554 

Method for generating mature beta-like cells


The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes..
The University Of Western Australia


02/18/16
20160045378 

Self-contained electronic device for detecting and alerting of the saturation of a protection layer article for urofecal incontinence


The invention relates to a self-contained electronic device for detecting and alerting of the saturation of a protection layer article used for urofecal incontinence, including at least one self-contained electrical generator module comprising an arrangement of pairs of elements having metal electrodes that are electrically connected to one another and distributed over a predetermined inner area of the article, made of zinc-copper in particular, intended for generating a current upon contact with an acidic and aqueous urofecal medium by means of a redox reaction, in order to electrically control, in a self-contained manner, the inner and outer means for giving notification of the saturation, in particular light means, sound means, or means for analogue or digital transmission of wired or wireless signals. The invention is useful in a protection layer article for urofecal incontinence for seniors or infants..

02/11/16
20160043730 

Umformerschaltung mit einer stromschnittstelle sowie meßgerät mit einer solchen umformerschaltung


A converter circuit serves to transform a digital measuring signal representing the chronological sequence of a periodically changing physical and/or chemical measurand into an analogue measure value signal dependent on the digital measuring signal with a signal current, an amperage of which represents a measuring value for the measurand. For this purpose the converter circuit comprises a current interface with a control input, with a current signal output and a current output.
Endress+hauser Flowtec Ag


02/11/16
20160041008 

Non-contact potentiometer


The present invention relates to a non-contact potentiometer. The non-contact potentiometer comprises the following parts: a mechanical housing with through-holes; a rotating shaft comprising a top end and a magnet end on which a permanent magnet is fixed and external torque can be applied to the top end, thus driving the rotating shaft and the permanent magnet to rotate around a rotation axis and relative to the housing; a magnetoresistive sensor assembly fixed inside the housing, comprising one or more sensor chips, the sensitivity axis of the sensor chips lies in a sensing plane that is perpendicular to the axis of the rotating shaft, and separated from the permanent magnet by a predetermined distance in the direction parallel to the axis of the rotating shaft, said sensors are used for sensing the magnetic variation produced as the permanent magnet rotates with the rotating shaft thereby generating sensing signals; and three electrical connection terminals, namely a ground terminal, a power terminal, and a signal output terminal.
Multidimension Technology Co., Ltd.


02/11/16
20160039781 

Novel analogues of epicatechin and related polyphenols


The present invention provides novel analogues of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.. .
Sphaera Pharma Pvt. Ltd.


02/11/16
20160039734 

Therapeutic curcumin derivatives


Curcumin analogues and methods are provided for treatment of disease.. .
Stc.unm




Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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