This page is updated frequently with new Analogue-related patent applications.
| Mitigating a phase anomaly in an analogue-to-digital converter output signal|
A method and apparatus for mitigating a phase anomaly in an analogue-to-digital converter (adc) output signal is disclosed. A plurality of codewords output by the adc are received and information about an estimated level of interference between an output of the adc and an input of the adc due to the codeword is obtained for each codeword based on the logic values of bits in the codeword.
Airbus Defence & Space Limited
| Connectors for audio data transfer|
This application relates to methods and apparatus for transfer of data between a host device (400) and a peripheral device (300) via a usb type-c connector (100; 304) of the host device. A data controller is described that has a path controller (309, 310; 706) for establishing signal paths between circuitry of the host device and contacts (101) of said usb type-c connector.
Cirrus Logic International Semiconductor Ltd.
| Electronic measurement circuit|
The electronic measurement circuit comprises a measurement sensor with two differential mounted capacitors each comprising a fixed electrode, and a common electrode arranged to move relative to the fixed capacitor electrode to alter the capacitive value when the physical parameter is measured. The circuit further comprises a first integrator unit connected to the common electrode for integrating charge received from the sensor, and comprising two integrators arranged to be connected alternately to the common electrode, a first comparator for comparing analogue output values from the first integrator unit, a second integrator unit for integrating charge received from the first integrator unit, a second comparator for comparing analogue output values from the second integrator unit, a switch circuit for switching different voltage values across the capacitors, and a feedback circuit for feeding a digital output signal from the first comparator to the switch circuit for controlling its operation, and an incremental calculation unit receiving digital output signals from the comparators and supplying a final digital output signal..
Em Microelectronic Marin S.a.
| Anti-viral pyrimidine nucleoside analogues|
A compound of formula (i) wherein ar can be one six-membered or two fused six-membered aromatic rings; r8 and r9 can be hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, or aryl; q can be o, s or cy2, where y may be h, alkyl or halogens; x can be o, nh, s, n-alkyl, (chr2)m where m is 1 to 10, and cy2; z can be o, s, nh, or n-alkyl; u″ is h and u′ can be h or ch2; wherein: t can be oh, h, halogens, o-alkyl, o-acyl, o-aryl, cn, nh2 or n3; t′ and t″ can be h or halogen; and w can be h or a phosphate group. Compounds show anti-viral activity, for example with respect to varicella zoster virus..
University College Cardiff Consultants Limited
| Method of producing beraprost|
An improved method is described for making single isomers of synthetic benzoprostacyclin analogue compounds, in particular the pharmacologically active 314-d isomer of beraprost. In contrast to the prior art, the method is stereoselective and requires fewer steps than the known methods for making these compounds..
Lung Biotechnology Pbc
| New pradimicin derivatives for the treatment of diseases caused by kinetoplastids|
The present invention relates to a class of novel pradimicins and analogues and derivatives thereof, including the compounds of formula a, i and 111, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof and their use to treat or prevent kinetoplastid infections and their use to manufacture a medicine to treat or prevent kinetoplastid infections, particularly infections with trypanosoma and leishmania, such as trypanosoma brucei, trypanosoma cruzi and leischmania donovani. Wherein ra, r1, r2, r3, r4, r5, r6, r7, r8 and r9 are as defined in the claim 1 or as described in detail in the description of the invention.
Consejo Superior De Investigaciones CientÍficas - Csic
| Tacrolimus for improved treatment of transplant patients|
An extended release oral dosage form comprising as active substance tacrolimus or a pharmaceutically active analogue thereof for a once daily immunosuppressive treatment of a patient in need thereof, preferable a kidney or liver transplant patient. The dosage form releases the active substance over an extended period of time.
Veloxis Pharmaceuticals A/s
| Controlled release pharmaceutical formulations of nitazoxanide|
Solid dosage formulations of nitazoxanide or a nitazoxanide analogue are provided that comprise a controlled release portion and an immediate release portion. The pharmaceutical composition is typically in the form of a bilayer solid oral dosage form comprising (a) a first layer comprising a first quantity of nitazoxanide or analogue thereof in a controlled release formulation; and (b) a second layer comprising a second quantity of nitazoxanide or analogue thereof in an immediate release formulation.
Romark Laboratories L.c.
| Compositions and methods for using esters of meroterpenes and of other resveratrol analogues|
The invention includes compositions and methods of using meroterpene esters for effectively modulating skin cell function and remediating undesirable skin conditions, as well as the use of such compositions in the treatment of systemic diseases, such as cancer and in nutritional, dermatologic and cosmetic applications, through topical and transbuccal delivery as well as by ingestion, injection or inhalation.. .
| Mono disperse polymer nanoparticles, functionalized nanoparticles and controlled formation method|
A method produces polymer nanoparticles. Polymer solution is sprayed through a nozzle toward a collector.
The Curators Of The University Of Missouri
Apparatus and transmitting and receiving beam information in wireless communication system
The present disclosure relates to transmitting and receiving beam information in a wireless communication system. An operation of a receiving end includes: generating a signal indicating two or more analogue transmission beams which are allocable to the receiving end; and transmitting the signal.
Samsung Electronics Co, Ltd.
Peptide oligonucleotide conjugates
Oligonucleotide analogues conjugated to carrier peptides are provided. The disclosed compounds are useful for the treatment of various diseases, for example diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..
Sarepta Therapeutics, Inc.
Stable aqueous parenteral pharmaceutical compositions of insulinotropic peptides
Disclosed herein is an insulinotropic peptide multi-dose aqueous parenteral pharmaceutical composition and use thereof. A long-term storage formulation of the insulinotropic peptide can be obtained via the method of the present disclosure.
Shanghai Benemae Pharmaceutical Corporation
Methods of inducing melanogenesis in a subject
Described herein are methods and compositions for inducing melanogenesis in a human subject. The method comprises administering to a subject an alpha-msh analogue, in an effective amount and time to induce melanogenesis by the melanocytes in epidermal tissue of subject without inducing homologous desensitization of the melanocortin-1 receptors..
Clinuvel Pharmaceuticals Limited
Compounds and methods for the treatment of vascular disease
The present invention relates to a method for the treatment of vascular dysfunction, reducing ischemic pain and/or treatment of a vascular disease comprising administering a therapeutically effective amount of annexin a5 or a functional analogue or variant thereof to a patient in need of such treatment. The vascular dysfunction, ischemic pain and/or vascular disease may be associated with impaired endothelium mediated vasodilatation, a reduced enos activity, and/or a reduced no bioavailability.
Annexin Pharmaceuticals Ab
A food product comprising a co-processed mixture, which mixture comprises at least one plant protein-containing composition and at least one rice carbohydrate-containing composition, which is particularly useful as a meat extender or a meat analogue, products containing said food products and processes for obtaining them.. .
Sudzucker Aktiengesellschaft Mannheim/ochsenfurt
Frozen dessert mixes using soy protein products
A soy protein product having a protein content of at least about 60 wt% (n×6.25) d.b., preferably at least about 90 wt %, and being completely soluble at ph values of less than about 4.4 and heat stable at such ph values is used to provide, at least in part, the protein component of a dairy analogue or plant/dairy blend frozen dessert mix.. .
Burcon Nutrascience (mb) Corp.
Process for the preparation of voriconazole and analogues thereof
The present invention provides a process for preparing a compound of formula: (formula xi and xii) (xi) (xii) wherein x, y, z, a, b and e are as defined herein, by reacting a compound of formula: (formula xiii) (xiii) with a compound of formula: (formula xiv and xv) (xiv) (xv) respectively, in the presence of a transition metal catalyst, a ligand suitable for use with 15 the catalyst and a reducing agent. The invention also provides novel intermediates..
Pfizer Ireland Pharmaceuticals
A process for the preparation of anti-inflammatory aroylbenzofuran compounds
Disclosed herein an efficient process for synthesis of benzofuran analogues having anti-inflammatory activity which comprises, ru-catalyzed branched and linear selective alkylation of aroylbenzofurans formula-i with alpha, beta unsaturated esters of formula-ii via c—h activation in presence of base, additives and organic solvent at suitable temperature to give high yield of desired linear alkylated benzofuran compounds of formula-iii or branched alkylated benzofuran compounds of formula-iv or mixture thereof.. .
Council Of Scientific And Industrial Research
Therapeutic compositions including phenazine-3-one and phenothiazine-3-one derivatives and uses thereof
Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of phenazine-3-one and/or phenothiazine-3-one derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to phenazine-3-one or phenothiazine-3-one derivatives and uses of the same.
Stealth Biotherapeutics Corp
Prostaglandin f2alpha and analogues thereof for treating atrophic cutaneous scarring
A method of treating atrophic cutaneous scarring in humans is claimed. The method involves the topical application of a therapeutic amount of prostaglandin f2-alpha (pgf 2α) or a pgf 2α analog directly to the area of atrophic scarring..
Hypertension reducing composition
A composition effective to relax smooth muscles in an individual in an altered state is described. The composition includes a dosage of gaba or gaba-a analogue, and a dosage of at least one of an ace inhibitor and an arb combined with the dosage of gaba or gaba-a analogue into a deliverable form..
Composition containing attractant of noxious arthropod comprising plant-derived component and analogue of same
This invention provides a composition with method of controlling and attracting noxious arthropods, and protecting plants from damage caused by noxious arthropods. The invention provides a noxious arthropod attractant composition that shows synergistic effects and comprises at least two types of compounds selected from the group consisting of p-anisaldehyde, benzaldehyde, ethyl nicotinate, geraniol, linalool, nerol, citronellol, o-anisaldehyde, β-farnesene, methyl anthranilate, methyl benzoate, o-aminoacetophenone, o-anisidine, methyl m-aminobenzoate, methyl o-toluate, eugenol, 3-phenylpropylaldehyde, cinnamaldehyde, eucalyptol, squalene and α-hexylcinnamaldehyde..
Kyoyu Agri Co., Ltd.
Hepcidin analogues and uses thereof
The present invention relates, inter alia, to certain hepcidin peptide analogues, including peptides and dimers thereof, and to the use of the peptides and peptide dimers in the treatment and/or prevention of a variety of diseases, conditions or disorders, including treatment and/or prevention of iron overload diseases, which include hereditary hemochromatosis and iron-loading anemias, and other conditions and disorders described herein.. .
Portagonist Therapeutics, Inc.
Uridine and uridine analogues for treatment of specific lung diseases, namely copd and pulmonary fibrosis
The present invention relates to the new indications of chronic obstructive pulmonary disease (copd) and idiophathic lung fibrosis (ipf) for uridine and uridine analogues.. .
Antibiotic compounds that inhibit bacterial protein synthesis
An aminoacylation/translation (ait) system based on the protein synthesis system from the pathogen pseudomonas aeruginosa, was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: ef-tu, ef-ts and ef-g, aminoacyl trna synthetase (aars) specific for phenylalanine, phers, and ribosomes isolated from cultures of pseudomonas aeruginosa.
The Board Of Regents Of The University Of Texas System
Built in self-test
A method for testing a dac comprising controlling the dac digitally to cause it to produce a known desired analogue output, for example a fixed amplitude sine wave; determining the duration of fixed voltage segments of the actual output of the dac and using the duration of the fixed voltage segments to assess or determine performance of the dac.. .
Apparatus for detecting noise in power supply of plc analogue input and output module
An apparatus for detecting noise in a power supply of a plc analog input/output module is provided. The apparatus may include a capacitor configured to extract a noise determination target voltage from a driving voltage outputted from the power supply; a voltage conversion unit configured to convert the noise determination target voltage outputted from the capacitor and to output the converted noise determination target voltage; a comparison unit configured to compare the noise determination target voltage converted by the voltage conversion unit with a reference voltage; and a determination unit configured to determine whether the noise determination target voltage is a noise, based on a comparison result by the comparison unit..
Lsis Co., Ltd.
Novel derivative of an insulin analogue
The present invention provides a novel derivative of an analogue of human insulin, useful for the treatment of diabetes.. .
Novo Nordisk A/s
Stabilized polypeptide insulin receptor modulators
Provided herein are stabilized α-ct polypeptides comprising an alpha-helical segment, and wherein the polypeptide is of formula (i-1) or formula (i-2): rf—[xaa]s—xa1—xa2—xa3—xa4—xa5—xa6—xa7—xa8—xa9—xa10—xa11—xa12—xa13—xa14—[xaa]t—re (i-1) rf—[xaa]s—xc1—xc2—xc3—xc4—xc5—xc6—xc7—xc8—xc9—xc10—xc11—xc12—xc13—xc14—xc15—xc16—xc17—xc18—xc19—xc20—[xaa]t—re (i-2) wherein the α-ct polypeptide binds to the insulin receptor, and wherein the α-ct polypeptide includes at least one staple (i.e. Two cross-linked amino acids) and/or at least one stitch (i.e.
President And Fellows Of Harvard College
Compositions for reducing hair loss and/or increasing hair regrowth
The invention relates to a composition comprising 2% to 5% minoxidil, 0.01% to 15% finasteride and 0.01% to 15% of a prostaglandin analogue. In one embodiment, the prostaglandin analogue is latanoprost.
Triple Hair, Inc.
Use of sarmentine and its analogues with an herbicide, and compositions thereof
Disclosed herein are methods for modulating (e.g., inhibiting) emergence and growth of monocotyledonous or dicotyledonous plants (e.g., weeds and grasses) using sarmentine and/or a sarmentine analogue and a second herbicide. The application of sarmentine and/or a sarmentine analogue with a second herbicide to a plant and/or its growth substrate results in a synergistic pre- and/or post-emergence herbicidal activity against the plant.
Marrone Bio Innovations, Inc.
Arrangement, system and methods therein for monitoring a transmission line
A method in an arrangement for monitoring a transmission line to a radio device in a communication network, wherein the transmission line comprises an optical part carrying signals in an optical domain and an electrical part carrying analogue information signals in an electrical domain. The arrangement selects a carrier in the electrical part for monitoring the transmission line by assigning a test signal to a subcarrier out of a number of subcarriers of an optical carrier, wherein the subcarrier in the optical domain corresponds to the selected carrier in the electrical domain.
Telefonaktiebolaget L M Ericsson (publ)
Method for transmitting and receiving sound waves using time-varying frequency-based symbol, and apparatus using the same
A method for transmitting sound waves using a time-varying frequency-based symbol includes the steps of: storing waveform data in a digital form; converting the waveform data in the digital form into an analogue signal; and outputting the analogue signal as sound waves through a speaker. Herein, the waveform data in the digital form includes a symbol the frequency of which changes with time within a sound wave band..
System and transmitting sensor data from a rotating component of a turbomachine
A system for transmitting data from a rotating component of a turbomachine includes a plurality of thermal sensors coupled to corresponding rotatable components within the turbomachine where each thermal sensor generates a discrete analogue signal indicative of temperature. A plurality of transmitter assemblies is coupled to an end of a rotor shaft of the turbomachine.
General Electric Company
Production of recombinant proteins utilizing non-antibiotic selection methods and the incorporation of non-natural amino acids therein
Provided herein are methods and compositions for expression of a nucleic acid construct comprising nucleic acids encoding a) a recombinant polypeptide, and b) a prototrophy-restoring enzyme in a host cell that is auxotrophic for at least one metabolite. In various embodiments, the host cell is auxotrophic for a nitrogenous base compound or an amino acid.
Cyclosporine analogue molecules modified at amino acid 1 and 3
Analogues of cyclosporin-a are disclosed comprising modifications of the substituents as the positions of amino acids 1 and 3, according to the following formula. The disclosed compounds include compounds having affinity for cyclophilin, including cyclophilin-a, and reduced immunosuppressivity in comparison with cyclosporin-a and analogs thereof modified solely at position 1..
Ciclofilin Pharmaceuticals Corp.
Phosphohistidine and phosphotyrosine analogues
The invention relates to phosphohistidine analogues. The invention also relates to antibodies that specifically bind to the analogues and methods of generating said antibodies.
University Of Sheffield
Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue
The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hghrelin.. .
Ipsen Pharma S.a.s.
Treatment and prevention of autism and autism spectrum disorders
In some embodiments, the present invention provides certain compositions and methods that may be useful in the treatment and/or prevention of a neurodevelopmental disorder, such as autism or an autism spectrum disorder (asd). In some such embodiments, compositions are provided that contain at least one fenamate active agent, such as mefenamic acid, or an analogue or derivative thereof.
The Rockefeller University
Light emitting device
A light emitting device includes at least one light emitting unit, a micro controller and a control module. The control module includes a storage unit configured to store a reference sheet between an intensity of the light emitting unit and a current value of the light emitting unit.
Hon Hai Precision Industry Co., Ltd.
Digital/analogue conversion apparatus
A digital/analog conversion apparatus to convert a digital signal into an analog signal. The digital/analog conversion apparatus can generate a high-quality analog signal, even when elements configuring the digital/analog conversion apparatus have variance, with high resolution and a small circuit size.
Trigence Semiconductor, Inc.
Method of transmiting data and a device and system thereof
A method for transmitting a data signal from a sending-end 100 to a receiving-end 200 includes the steps of spreading the data signal into a spread spectrum signal, combining the spread signal with an analogue signal into a mixed signal. The mixed signal can be transmitted or broadcasted to the receiving-end 200.
Well Being Digital Limited
Bulk driven low swing driver
A circuit is presented to reduce power while transmitting high speed signals across a long length of wire on an integrated circuit. A pmos is used as a low swing driver, where the pmos is connected between the driver's output and ground.
Sandisk Technologies Inc.
Glp-1 derivatives, and uses thereof
The present invention relates to tri-acylated glp-1 derivatives, acylated at positions corresponding to positions (18, 22, 30), (18, 26, 37), (18, 27, 37), (26, 30, 37), or (27, 30, 37) of the native human glucagon-like peptide 1 (glp-1 (7-37) (seq id no: 1); or pharmaceutically acceptable salts, amides, or esters thereof. The acylated side chains comprise a protracting moiety selected from chem.
Novo Nordisk A/s
Radiosensitivity of fluorophores and use of radioprotective agents for dual-modality imaging
The present application discloses compositions and methods of use of dual-labeled molecules comprising a fluorescent probe and a radionuclide. The labeled molecules are of use for detection, imaging and/or diagnosis of diseased tissues, such as tumors.
Compounds compositions and methods including thermally labile moieties
The present invention generally relates to compounds that include one or more thermally labile protecting groups, compositions including the compounds, methods of making the compounds and compositions and methods of using the compounds and compositions. In one aspect, the present invention is directed to a compound of the structure xo—ch2—sm-b-a.
Biosearch Technologies, Inc.
Therapeutic compositions including iron chelators and uses thereof
Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of at least one iron chelator, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to at least one iron chelator and uses of the same.
Pyrazoloanthrone and derivatives thereof for treatment of cancers expressing missrii
The present invention relates to pyrazoloanthrones or functional derivatives or functional analogues thereof to activate mis receptor-mediated downstream effects in a cell. In particular, the present invention relates to method to prevent and treat cancer that expresses mis receptor type ii (misrii) by administering to a subject at least one pyrazoloanthrone or a functional derivative or a functional analogue thereof.
The General Hospital Corporation
Radio repeater system
A system and/or method for facilitating wireless communication in an area where it is difficult to transmit and receive signals may use a preexisting wired emergency communication infrastructure to transmit signals between elements of a radio repeater system. Optionally, the system may include synchronization of retransmissions.
Liposomal curcumin for treatment of cancer
The present invention provides a compositions and methods for the treatment of cancer, including pancreatic cancer, breast cancer and melanoma, in a human patient. The methods and compositions of the present invention employ curcumin or a curcumin analogue encapsulated in a colloidal drug delivery system, preferably a liposomal drug delivery system.
Board Of Regents, The University Of Texas System
Feline scratch marking semiochemicals
Semiochemical compositions comprising a feline scratch marking semiochemical analogues of these semiochemical compositions and a method to prevent cats from scratching in particular places and on multiple objects are described.. .
Institut De Recherche En Semiochimie Et Ethologie Appliquee
Measuring transducer for converting an analogue electrical input signal into an analog electrical output signal
A measuring transducer for converting an analog electrical input signal into an analog electrical output signal. The measuring transducer contains a detection apparatus which is designed to detect an analog electrical input signal within a predetermined input measurement range, wherein the input measurement range of the measuring transducer is divided into n adjustable partial input measurement ranges and the output range of the measuring transducer is divided into n adjustable partial output ranges, where n is greater than 1.
Codon-optimized gene for mutated shrimp luciferase and use thereof
There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.
Cortistatin analogues for the treatment of inflammatory and/or immune diseases
The invention relates to cortistatin analogues and their uses. The compounds of the invention are peptide ligands with potential application in the diagnosis, prevention or therapy of those pathologies where receptors capable of binding to cortistatin, specific or shared with other molecules such as somatostatin and/or ghrelin (ghsr), are expressed, being in addition more stable in serum than cortistatin..
Novel indazole compounds and a process for the preparation thereof
The patent discloses novel indazole compounds of general formula 1 and analogues thereof, use thereof for the treatment of diabetes, diabetic complications, cardiovascular dysfuntion or related diseases, pharmaceutical compositions comprising them and processes for their preparation.. .
Aqueous sustained release compositions of lhrh analogues
An aqueous pharmaceutical composition for the sustained release of an lhrh analogue, in particular for a sustained release compatible with therapeutic treatments for at least 2 weeks. The pharmaceutical compositions are particularly useful for the treatment of diseases an lhrh analogue is indicated for..
Heterocyclyl pyrimidine analogues as tyk2 inhibitors
Wherein r, r1, x1 to x5 have the meaning as cited in the description and the claims. Said compounds are useful as tyk2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases.
The present invention relates to rodenticides, methods of killing a rodent comprising administering to said rodent, a lethal dose of an isolated yersinia murine toxin polypeptide or an isolated antigenic analogue thereof, and methods of manufacturing novel rodenticides.. .
Functionalized carboranyl magnesium electrolyte for magnesium battery
Electrochemical devices and processes for forming them employ a functionalized carboranyl magnesium electrolyte. The functionalized carboranyl electrolyte includes a carboranyl anion functionalized with at least one halide, or one alkyl, aryl, alkoxy, and/or aryloxy groups, or their partially or completely fluorinated analogues.
Functionalized carboranyl magnesium electrolyte for magnesium battery
An electrochemical device is provided having a functionalized carboranyl magnesium electrolyte. Specifically the disclosure relates to an electrochemical device having a magnesium anode, a cathode, a current collector made of non-noble metal, and a functionalized carboranyl magnesium electrolyte.
A connecting device comprises housing, a board with electrical components, including at least one digital bus connection and an input/output section. It allows outsourcing of analogue and digital i/o from a connected device, e.g.
Electromechanical apparatus comprising a capacitive device for detection of the angular position of a wheel set, and detection of the angular position of a wheel set
Electromechanical apparatus comprising a wheel set and an analogue indicator member (14) which are integral in rotation, a stepping motor, and a capacitive device for detection of the angular position of the wheel set, comprising a rotor (4: 10), a stator (18a, 18b, 20a, 20b, 22, 24, 26a, 26b, 26c) and an electronic measuring circuit (28), the stator comprising a first pair of electrodes (18a, 18b) having a first capacitance (c1) and a second pair of electrodes (20a, 20b) having a second capacitance (c2), the rotor being adapted such that the values of the two capacitances depend on the angular position of the rotor, and an electronic measuring circuit (28) being provided for generating an output signal representative of a difference between the respective values of the first (c1) and of the second (c2) capacitance.. .
Enzymatic transamination of cyclopamine analogs
Provided are processes for the synthesis of amino analogues from ketone starting materials.. .
Method for producing dopaminergic neurons
The present invention provides a method of more efficiently producing a high-quality dopaminergic neuron from neural progenitor cells, specifically, a production method of a dopaminergic neuron including a step of culturing neural progenitor cells in a medium containing (i) a camp analogue and (ii) a mek inhibitor. Moreover, the present invention also provides a medicament containing a dopaminergic neuron obtained by the method, and a reagent and a kit to be used for the method..
Modified peptides as potent inhibitors of the psd-95/nmda receptor interaction
The present invention is directed to the provision of small molecule inhibitors of the psd-95/nmda receptor interaction, employing an undecapeptide corresponding to the c-terminal of the nmda as a template for finding lead candidates. A compound (nmdar/psd-95 inhibitor) of the invention includes a peptide or peptide analogue comprising at least four peptide bonded residues having the sequence ytxv or ysxv, wherein y is selected from among e, q, and a, or an analogue thereof, and x is selected from among a, q, d, n, n-me-a, n-me-q, n-me-d, and n-me-n or an analogue thereof, wherein an amino-terminal residue of the peptide is n-alkylated.
Rapamycin analogues and their pharmaceutical use
Novel rapamycin analogues and methods for their production with fkbp and/or mip inhibitory activity with reduced mtor inhibitory activity with therapeutic potential e.g. As bacterial virulence inhibitors..
Amino acid derivatives
There are provided pyrrolysine analogues of the formulae (x), (i), (ii), (v), (vi), (vii) and (viii), in which the a, b, d, x, y, z, fg, r, r1, r2 and r3 are as defined in the claims, which are useful in bioconjugation processes and mutant proteins containing them.. .
Composition for the treatment of cystic fibrosis
The present invention provides compositions comprising a prostacyclin or prostacyclin analogue, or a pharmaceutically acceptable salt thereof for use in preventing or treating cystic fibrosis. The invention also provides the use of a kit comprising a prostacyclin or prostacyclin analogue for treating or preventing a condition associated with cystic fibrosis in a subject..
Disclosed herein are veterinary compositions including imidacloprid or an analogue thereof; a pyrethroid; a solvent selected from the group consisting of n-methyl pyrrolidone, n-ethyl pyrrolidone and mixtures thereof; and dimethyl sulfoxide. The veterinary compositions of the invention are useful in methods of controlling parasites on or within warm-blooded domesticated animals..
Video signal attenuation equalization circuit, processing apparatus, and control device and method
Disclosed are a video signal attenuation equalization circuit, a video signal processing apparatus, and a control device and method, which are used for solving the problem that the transmission of an analogue video signal is distorted after the analogue video signal is transmitted by a coaxial cable, so as to guarantee low signal distortion after the video signal is transmitted at a long distance. The video signal attenuation equalization circuit provided in the embodiments of the present invention comprises: a signal driving circuit, an equalization unit and an analogue switch unit, wherein the signal driving circuit is connected to the equalization unit and the analogue switch unit, and is used for receiving and strengthening an initial video signal, and sending the obtained strengthened initial video signal to the equalization unit and the analogue switch unit; the equalization unit is used for performing attenuation equalization on the strengthened initial video signal according to the triggering of a control signal, and after the attenuation equalization sending the video signal to the analogue switch unit; and the analogue switch unit is used for outputting the strengthened initial video signal or the video signal sent by the equalization unit after the attenuation equalization according to the control of the control signal..
Zhejiang Dahua Technology Co., Ltd.
Use of a cable for the transmission of audio signals
According to the invention, a cable (10) is used to transmit audio signals, in particular analogue audio signals. Said cable comprises at least two conductors (12.1, 12.2, 12.3, 12.4), a first connection piece on a first end of the cable (10) for connecting the cable (10) to a first device and a second connection piece on a second end of the cable (10) for connecting the cable (10) to a second device.
Process for production of insulin and insulin analogues
A process for production of insulin or insulin analogues by expression of insulin or insulin analogues through an expression vector in a host cell is provided. The expression vector includes a leader peptide of seq id no 3; a nucleotide sequence encoding an affinity tag linked to c-terminal end or n terminal end of nucleotide sequence of the leader peptide; and a nucleotide sequence encoding for a cleavage site ligated to nucleotide sequence of the leader peptide through nucleotide sequence encoding the affinity tag..
Exendin-4 peptide analogues as dual glp-1/glucagon receptor agonists
The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake. .
Substituted pyridine-piperazinyl analogues as rsv antiviral compounds
The invention concerns novel substituted pyridine-piperazinyl analogues of formula (i) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (rsv). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection..
Janssen Sciences Ireland Uc
Chemically and thermodynamically stable insulin analogues and improved methods for their production
The subject matter of this invention is directed towards chemically and thermodynamically stable single-chain insulin (sci) analogues that are resistant to deamidation and fibrillation. The invention further discloses improved methods for the recombinant expression, purification and refolding of sci..
Glycosylated pacap/vip analogues with enhanced cns penetration for treatment of neurodegenerative diseases
A glycosylated pleiotropic peptide pituitary adenylate cyclase-activating polypeptide (pacap) which can both agonize pac1 receptors, causing neuroprotective effects, and antagonize vpac receptors, causing anti-inflammation in several models of acute neuronal damage and neurodegenerative diseases, including als, pd, migraines, and certain forms of dementia, is described. Also described is a method of relieving symptoms of als, pd, migraines, and certain forms of dementia, comprising administering to a subject in need thereof an effective amount of a glycosylated pacap..
The Arizona Board Of Regents On Behalf Of The University Of Arizona
Compositions and methods to treat cardiac diseases
Phosphonate and phosphinate n-methanocarba derivatives of amp including their prodrug analogs are described. Mrs2339, a 2-chloro-amp derivative containing a (n)-methanocarba (bicyclo[3.1.0]hexane) ring system in place of ribose, activates p2x receptors, ligand-gated ion channels.
The United States Of America As Represented By The Secretary Department Of Health And Human Services
Current sensing circuit and organic light emitting diode display including the same
Discussed are a current sensing circuit capable of compensating for degradation of an organic light emitting diode by sensing a current of the organic light emitting diode, and an organic light emitting diode display having the same. The current sensing circuit according to an embodiment includes a plurality of sensing modules configured to sense a pixel current from a display panel having an organic light emitting diode on each of a plurality of pixels, and to output a sensing voltage according to a sensing result; and an analogue-digital converter configured to convert the sensing voltage into an analogue-digital voltage, and to output sensing data..
Lg Display Co., Ltd.
Method for preparation of 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4as,7as)-octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid
This invention relates to methods for preparation of chemical compound 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4a8,7as)-octahydro-6h-pyrrolo[3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid, which comprise addition of heterocyclic amine containing protecting group, to ethyl-3-oxo-3-(2,4,5-trifluoro-3-methoxyphenyl)propanoate, followed by interaction with triethyl orthoformate, addition of cyclic amine, subsequent cyclization and formation of target product. The method for preparation claimed is technologically simple in comparison with analogue and requires no special complex technical operations, which in its turn simplifies method for preparation of this chemical compound, and reduces cost of the final product, while the commercial production utilizing the mehod claimed has low degree of environmental threat..
Scaffold for hard tissue regeneration containing active ingredient for treating osteoporosis and preparing method thereof
A scaffold for hard tissue regeneration comprising an active ingredient for treating osteoporosis and a preparation method thereof. The scaffold for hard tissue regeneration is prepared by the steps of mixing a polyphenol-based natural substance containing quercetein or genistein involved in the activation of osteoblasts and osteoclasts and the biofunctional analogue thereof with a ceramic scaffold material and molding the mixture at room temperature into a three-dimensional scaffold.
Korea Institute Of Machinery And Materials
Pharmaceutical compositions comprising attenuated plasmodium sporozoites and glycolipid adjuvants
Disclosed herein are pharmaceutical compositions comprising plasmodium sporozoite-stage parasites and compatible glycolipid adjuvants useful in vaccines for preventing or reducing the risk of malaria. In particular, human host range plasmodium and analogues of α-galactosylceramide (α-galcer), a ligand for natural killer t (nkt) cells, are combined in pharmaceutical compositions, which are useful as vaccines against malaria.
The Rockefeller University
Treatment of pediatric growth hormone deficiency with human growth hormone analogues
The present invention concerns a pediatric growth hormone deficiency (pghd) therapy for pediatric subjects. The therapy comprises administering to the pediatric patient with pghd a human growth hormone-xten (hgh-xten) fusion protein in therapeutically effective doses every week, every two weeks, semimonthly, every three weeks, or monthly.
Amunix Operting Inc.
Method for treating gefitinib-resistant non-small-cell lung cancer
The present invention relates to a method for treating gefitinib-resistant non-small-cell lung cancer (nsclc) comprising administering an effective amount of a resveratrol analogue, (z)3,4,5,4′-tetramethoxystilbene (tms), to a subject in need thereof. The present invention also relates to a method for inducing apoptosis in gefitinib-resistant nsclc cells comprising contacting the resveratrol analogue to the cells at an effective amount.
Macau University Of Science And Technology
Antifungal composition and method
A composition comprising a surfactant, a co-surfactant, and a vanillin or an analogue thereof, that can be used to inhibit the growth of fungus on plants. The composition is diluted with water to form an oil-in-water microemulsion which can be applied to plants to inhibit the growth of fungus on plants..
Omex International Limited
Signal processing for mems capacitive transducers
This application relates to circuitry for processing sense signals generated by mems capacitive transducers for compensating for distortion in such sense signals. The circuitry has a signal path between an input (204) for receiving the sense signal and an output (205) for outputting an output signal based on said sense signal.
Cirrus Logic International Semiconductor Limited
Cadherin 15 agonists
Cdh15 has been identified as a receptor for a peptide which has an inhibitory effect of the migration of t cells. Agonists of this receptor have applications in the treatment and/or prophylaxis of conditions associated with the migration of t-cells, including t cell auto-reactivity, t cell mediated chronic inflammatory disease and autoimmune disease.
The University Of Birmingham
Peptide therapeutics and methods for using same
Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of an mpp, and/or naturally or artificially occurring variants or analogues of an mpp, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as d-arg-2′6′-dmt-lys-phe-nh2).. .
Stealth Biotherapeutics Corp
Non-flushing niacin analogues, and methods of use thereof
One aspect of the present invention relates to substituted pyridines and pharmaceutically acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the invention relates to a pharmaceutical composition, comprising a compound of the present invention or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.
Trustees Of Tufts College
Nuclease-resistant dna analogues
The present invention provides stable, nuclease-resistant tna and tna-dna oligonucleotides, wherein the oligonucleotides are completely resistant to enzymatic degradation for at least 24-72 hours. Methods of synthesis and use in diagnostic and therapeutic applications are also provided.
Methods of generating cells with multilineage potential
The present invention relates to methods for generating mammalian multilineage-potential cells, including mesenchymal stem cells, comprising contacting mammalian somatic cells exhibiting a mature phenotype with pdgf-ab or functional derivative, fragment or mimetic thereof and azacitidine or functional derivative or analogue thereof for a time and under conditions sufficient to induce the transition of the somatic cells to cells exhibiting multilineage differentiative potential. Also provided are uses of said multilineage-potential cells, such as in promoting tissue repair and regeneration..
Newsouth Innovations Pty Limited
Compositions and methods of using therapeutic p53 peptides and analogues
The present invention relates to compositions useful in inhibiting bcl-xl or mcl-1 and disrupting p53-mdm2 and p53-mdmx interactions, and methods of using those compositions for treating a subject for conditions responsive to increasing p53 mediated activity or promoting p53 independent apoptosis, such as treating cancer. In some aspects, the compositions of this invention relate to fusion polypeptides comprising a human serum polypeptide and a p53-peptide, which can be, in some aspects, a p53 derived peptide and/or a p53 activating peptide..
University Of The Sciences Of Philadelphia
Glp-1 derivatives and uses thereof
The invention relates to a derivative of a glp-1 analogue, optionally c-terminally extended, which derivative comprises a first and a second protracting moiety in the form of a c20 or c22 diacid radical, a bis-amino branched linker, and a first and a second further linker each comprising an oeg-like linker element; wherein these elements are interconnected via amide bonds and attached to a lys residue of the glp-1 analogue. The invention also relates to intermediate products in the form of novel glp-1 analogues incorporated in the derivatives of the invention, as well pharmaceutical compositions and medical uses of the derivatives.
Novo Nordisk A/s
Methods and compositions for treating clostridium difficile associated disease
Methods for treating a subject infected with clostridium difficile comprises administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of clofazimine and/or a clofazimine analogue. Pharmaceutical compositions comprising clofazimine and/or an analogue(s) thereof, and optionally one or more additional therapeutic agents, are provided for treating clostridium difficile infection and diseases or symptoms associated therewith..
Wiring structure for electroacoustic transducer for digital signal and headphone for digital signal
A wiring structure is provided for an electroacoustic transducer directly converting digital signals from a single sound source to sound waves without conversion to analogue signals. The structure includes a diaphragm, and a plurality of voice coils fixed to the diaphragm.
Kabushiki Kaisha Audio-technica
Method and device for transmission of multimedia data
The present disclosure discloses a method for transmission of multimedia data, which includes: converting analogue multimedia data received from a terminal to digital multimedia data; separating the digital multimedia data into digital audio data and digital video data, and converting coding format of the digital video data; compressing the digital audio data and the digital video data in converted thecoding format respectively, converting protocol format of the compressed digital audio data and of the compressed digital video data respectively, and sending the resulting digital audio data and the resulting digital video data to a network. The present disclosure further discloses a device for transmission of multimedia data.
Energy-efficient system for distant measurement of analogue signals
An energy-efficient system for measurement of analogue signals including one or more measuring units. Each measuring unit has a measuring probe which signal is processed by a modulator.
Elektrotehnicki Fakultet Sveucilista U Osijeku
Biomarkers for the diagnosis and the response to treatment of pancreatic cancer
The invention related to biomarkers, a method and a kit for early diagnosis of pancreatic cancer, in particular of pancreatic ductal adenocarcinoma (pdac); and to biomarkers, a method and a kit or device for predicting or prognosticating an individual's response to combination treatment with a nucleoside analogue (preferably gemcitabine) and with a growth factor receptor (preferably erlotinib) in patients with pancreatic ductal adenocarcinoma.. .
Universidad De JaÉn
Flat panel test hardware and technology for assessing ballistic performance of helmet personnel protective equipment
A testing apparatus to assess ballistic performance of helmet personnel protective equipment having a flat helmet analogue with a helmet shell material in flat panel form and at least one helmet suspension pad; head surrogate components including a skull skin surrogate, a skull bone surrogate, and a brain tissue surrogate; a pressure indicating film adjacent to the head surrogate components; and one or more pressure sensors in the brain tissue surrogate. Also disclosed is the related method for assessing ballistic performance of helmet personnel protective equipment..