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This page is updated frequently with new Analogue-related patent applications.




Date/App# patent app List of recent Analogue-related patents
04/28/16
20160115216 
 Method for making mature insulin polypeptides patent thumbnailMethod for making mature insulin polypeptides
This invention relates to an improved method for making mature human insulin or an analogue thereof by cultivating fungi cell comprising a dna sequence encoding a precursor for human insulin or an analogue thereof, which precursor comprises a small connecting peptide.. .
Novo Nordisk A/s


04/28/16
20160115179 
 Spiro-oxazines, indolinones and preparation thereof patent thumbnailSpiro-oxazines, indolinones and preparation thereof
The present invention relates to novel spiro-oxazine analogues of formula-i and indolinone compounds of formula-ii or positional isomers, or stereoisomers, or derivatives, or pharmaceutically acceptable salt thereof. Formula-i formula-ii further the invention provides transition-metal free multicomponent reaction (mcr) process for the preparation of said compounds of formula-i and ii using aryne precursor, n-substituted isatin and n-heteroaromatic compound as the nucleophile, under mild condition leading to formation of desired complex of spiro-oxazine analogues (i) and indolinone analogues (ii) in high yield and selectivity..
Council Of Scientific & Industrial Research


04/28/16
20160115173 
 Methods and compositions for studying, imaging, and treating pain patent thumbnailMethods and compositions for studying, imaging, and treating pain
In embodiments, the present disclosure provides a method for alleviating pain in a subject in need of treatment, the method comprising administering to the subject an effective amount of a saxitoxin analogue compound, or a pharmaceutically acceptable salt, isomer, tautomer or prodrug thereof, whereby pain in said subject is alleviated.. .

04/28/16
20160115112 
 Novel n-3 immunoresolvents: structures and actions patent thumbnailNovel n-3 immunoresolvents: structures and actions
The invention describes novel mono-hydroxy, di-hydroxy and tri-hydroxy docosapentaenoic acid (dpa) analogues, their preparation, isolation, identification, purification and uses thereof. Resolution of inflammation is now held to be an active process where autacoids promote homeostasis.
The Brigham & Women's Hospital Inc.


04/21/16
20160112796 
 Analogue signal processing circuit for microphone patent thumbnailAnalogue signal processing circuit for microphone
An analog signal processing circuit of a microphone includes a bias circuit including a first sub-circuit which receives a signal from the microphone to output a first signal and a second sub-circuit which receives a reference voltage to output a second signal. A fully differential circuit receives the first signal and the second signal to output a fully differential signal.

04/21/16
20160107977 
 Methods of synthesis of ingenol and intermediates thereof patent thumbnailMethods of synthesis of ingenol and intermediates thereof
The present invention relates generally to methods of synthesis of diterpene heterocylic compounds. More particularly, the present invention relates to efficient methods of synthesis of ingenol (formula (21), cas 30220-46-3), from a compound of formula (1).

04/21/16
20160106768 
 Lysophospholipids and lysophospholipid analogues against honeybee brood diseases patent thumbnailLysophospholipids and lysophospholipid analogues against honeybee brood diseases
The present invention refers to a compound selected from the group consisting of a lysophospholipid and a lysophospholipid analogue for use in the treatment or prophylaxis of honeybee brood diseases, in particular american foulbrood and european foulbrood. The invention also refers to a diet composition, a sprayable composition, a dipping solution for brood combs, a beeswax composition and liposomal and microsphere- or nanosphere-based compositions, comprising a compound according to the invention, for use in the treatment or prophylaxis of bee brood diseases..

04/14/16
20160104404 
 Detection circuit and  a liquid crystal display patent thumbnailDetection circuit and a liquid crystal display
A detection circuit and a detection method for liquid crystal display are provided. The detection circuit comprises a gate driver for providing row scan signal to liquid crystal cell to be detected; a signal source for providing polarity inversion signal to source driver; a source driver for performing digital-analogue conversion on received display data signal according to preset reference voltage and polarity inversion signal, generating pixel voltage signal, and sending pixel voltage signal to liquid crystal cell to be detected.

04/14/16
20160103527 
 Identification and data interchange system having a portable capacitive device and a capacitive touch screen patent thumbnailIdentification and data interchange system having a portable capacitive device and a capacitive touch screen
The general field of the invention is that of systems having a capacitive touch screen. The system according to the invention has a portable capacitive device that is intended, in operational mode, to be carried by a user.

04/14/16
20160102307 
 Oligonucleotide analogues targeting human lmna patent thumbnailOligonucleotide analogues targeting human lmna
Provided are lmna-targeted antisense oligonucleotides for reducing expression of one or more aberrantly spliced lmna mrna isoforms that encode progerin.. .

04/14/16
20160102126 

Novel peptides involved in energy homeostasis


The expression of a mrna encoding a putative 76 amino acid, secreted protein (“enho1”) was found to negatively correlate with fasting triglyceride and cholesterol levels. A recombinant adenovirus was used to increase the expression of enho1 mrna in two mouse models of obesity, kk-ay and lepob/lepob mice.

04/14/16
20160101158 

Peptide therapeutics and methods for using same


Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of glp-1, and/or naturally or artificially occurring variants or analogues of glp-1, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as d-arg-2′6′-dmt-lys-phe-nh2).. .

03/31/16
20160094927 

Headphone device


The invention provides an apparatus that allows the user or a third party to easily monitor the volume levels of a set of headphones before and during use so as to prevent damage to the anatomy of the user's ears as a result of exposure to excessive noise volume. An analogue meter indicative of the signal level being input to or reproduced by the transducer within one or both of the headphone cans is provided, built into the outer surface of the headphone can so that it is easily visible to a user who is about to put on the headphones, or to a third party viewing the user wearing the headphones.
Ashdown Design & Marketing Limited


03/31/16
20160090621 

Design and synthesis of cleavable fluorescent nucleotides as reversible terminators for dna sequencing by synthesis


This invention provides novel azido linkers for deoxynucleotide analogues having a detectable marker attached thereto.. .
The Trustees Of Columbia University In The City Of New York


03/31/16
20160090579 

Modified polymerases for improved incorporation of nucleotide analogues


Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.. .
Illumina, Inc.


03/24/16
20160087614 

System for generating an analogue signal


The system has: a set of at least two electric current generators, at least one capacitor and activation/deactivation devices for the electric current generators; the electric current generator being connected in parallel with one another and the capacitor being connected in series with the electric current generators, the activation/deactivation devices controlling the generators by a digital stream allowing control of the intensity of the electric current entering the capacitor and generating a trapezoidal voltage signal at the terminals of the capacitor, the analog signal being reconstructed through interpolation of the trapezoidal signal.. .
Atlantic Innovation Electronic Solutions


03/24/16
20160084703 

Detection of radiation quanta using an optical detector pixel array and pixel cell trigger state sensing circuits


The invention relates to a radiation detection device for integrating the number of optical photons in a light pulse. A system, a method and a computer program product are also disclosed.
Koninklijke Philips N.v.


03/24/16
20160084073 

High temperature downhole gauge system


A gauge system and method for monitoring well pressure at temperatures in excess of 300° c. Used in permanent monitoring of oil and gas wellbores.
Zenith Oilfield Technology Limited


03/24/16
20160083448 

Site 2 insulin analogues


An insulin analogue contains one or more modifications at a distinct protein surface comprising one or more of the residues at position b13, b17, a12, a13, and/or a17. Formulations of the above analogues at successive strengths u-100 to u-1000 in soluble solutions a at least ph value in the range 6.8-8.0 either in the presence of zinc ions at a molar ratio of 2.2-10 zinc ions per six insulin analogue monomers or in the presence of fewer than 1 zinc ions per six insulin analogue monomers.
Case Western Reserve University


03/24/16
20160083447 

Double-acylated glp-1 derivatives


The invention relates to a derivative of a glp-1 analogue, which analogue comprises a first k residue at a position corresponding to position 27 of glp-1(7-37) (seq id no: 1); a second k residue at a position corresponding to position t of glp-1(7-37), where t is an integer in the range of 7-37 except 18 and 27; and a maximum of ten amino acid changes as compared to glp-1(7-37); wherein the first k residue is designated k27, and the second k residue is designated kt; which derivative comprises two albumin binding moieties attached to k27 and kt, respectively, via a linker, wherein the albumin binding moiety comprises a protracting moiety selected from hooc—(ch2)x—co— and hooc—c6h4—o—(ch2)y—co—; in which x is an integer in the range of 6-16, and y is an integer in the range of 3-17; wherein the linker comprises an element of the formula —nh—(ch2)2—(o—(ch2)2)k(ch2)n—co—, wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel glp-1 analogues.
Novo Nordisk A/s


03/17/16
20160078255 

Method and device for reading rfid/uhf label based on audio interface


A method and a device for reading rfid/uhf label based on an audio interface are disclosed. According to the method, a built-in software module in an electronic device converts a first digital signal into an analogue signal capable of being transmitted via the audio interface; the analogue signal received by the audio interface is converted into a second digital signal via an audio communication circuit; then the rfid/uhf controller for digital signal control reads information from the rfid/uhf label; the rfid/uhf controller modulates and sends signals of a plurality of different frequency points, and the signal of every frequency point forms a signal channel.
Xiamen Innov Electronics Tech Co., Ltd.


03/17/16
20160077175 

Magnetic resonance imaging apparatus


According to one embodiment, an mri apparatus includes a bed, a digital processing circuit, a first antenna, first radio communication circuitry, a second antenna, second radio communication circuitry, and an image reconstruction circuit. An object is loaded on the bed.
Kabushiki Kaisha Toshiba


03/17/16
20160077042 

Phosphate sensor, its use and its preparation


A phosphate sensor employs a membrane which comprises a molecularly imprinted polymer produced from a thiourea derivative as functional monomer and a phosphate analogue (e.g. Phenylphosphonic acid) as template.
Yorkshire Water Services Limited


03/17/16
20160076070 

Biocatalytic production of nucleoside analogues as active pharmaceutical ingredients


And wherein said nas are active as pharmaceutically relevant antivirals and anticancer medicaments, intermediates or prodrugs thereof.. .

03/17/16
20160075750 

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.

03/17/16
20160075741 

Cyclosporine analogue mixtures and their use as immunomodulating agents


The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine a. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives.
Aurinia Pharmaceuticals Inc.


03/17/16
20160075652 

Synthetic analogues of xanthohumol


The present invention relates to novel synthetic analogues of xanthohumol and the use thereof.. .
Azienda Ospedaliera Arcispedale Santa Maria Nouva / Irccs Istituto In Tecnologie Avanzate E Modelli


03/17/16
20160074469 

Alpha-and gamma-msh analogues


The present invention provides peptide analogues of α-msh and γ-msh, comprising the amino acid sequence of human α-msh or γ-msh, or variants thereof, and having a branched amino acid probe in the n-terminal part of the peptide.. .
Txp Pharma Gmbh


03/17/16
20160074355 

Methods of treating sickle cell disease and related disorders using fumaric acid esters


Methods of using one or more fumaric acid esters or pharmacologically active salts, derivatives, analogues, or prodrugs thereof to increase expression of fetal hemoglobin (hbf) are disclosed. The methods typically include administering to a subject an effective amount of one or more fumaric acid esters optionally in combination or alternation with hydroxyurea to induce hbf expression in the subject in an effective amount to reduce one or more symptoms of a sickle cell disorder, a hemoglobinopathy, or a beta-thalassemia, or to compensate for a genetic mutation is the human beta-globin gene (hbb) or an expression control sequence thereof.
Georgia Regents Research Institute, Inc.


03/17/16
20160074346 

Method of viral inhibition


This invention relates to methods of treating or preventing viral infections caused by flaviviruses, such as dengue virus, yellow fever virus, west nile virus or japanese encephalitis virus or infections caused by chikungunya virus (chikv). The methods involve the administration of retinoic acid analogues to subjects who have, are suspected of having a flavivirus infection or infection with chikv, or to those who are at risk of becoming infected with a flavivirus or becoming infected with chikv..
Monash University


03/10/16
20160068809 

Use of zeburaline for the treatment of autoimmune diseases or immune rejection of transplants


The invention relates to the use of 1-(β-d-ribofuranosyl)-1,2-dihydropyrimidin-2-one derivative or mimetic or an analogue, derivatives, metabolites, variants or salts thereof for the manufacturing of a medicament to increase the amount of indoleamine 2,3-dioxygenase (ido) production in order to induce immunological tolerance as well as a method of treating a mammal in need thereof.. .
Idogen Ab


03/10/16
20160068579 

Trap 63


The present invention for the first time discloses a novel small molecular weight enamel matrix polypeptide which is at least 80%, such as 90% identical to the amino acid sequence as shown in seq id no: 1 (mplpphpghp gyinfsyevl tplkwyqnmi rhpytsygye pmggwlhhqi ipwsqqtpq sha) (trap63), a homologue, analogue, or a pharmaceutically acceptable salt thereof. The present invention further discloses a pharmaceutical composition consisting of an enamel matrix polypeptide which is at least 80%, such as 90% identical to the amino acid sequence as shown in seq id no: 1, a homologue, analogue, or a pharmaceutically acceptable salt thereof, and a suitable pharmaceutical carrier, which further can consist of one or more enamel matrix polypeptides selected from the group of enamel matrix polypeptides which correspond to: a.
Straumann Holding Ag


03/10/16
20160068527 

The treatment of inflammatory disorders


The present invention provides nalidixic acid and analogues of nalidixic acid, and methods for treating inflammatory disorders. The nalidixic acid and analogues of nalidixic acid may be formulated for topical delivery or systemic delivery.
Cresset Biomolecular Discovery Ltd.


03/03/16
20160061900 

Method and device for measuring a dc voltage such as the voltage of a motor vehicle battery


A method for measuring a dc voltage such as the voltage vbat of a motor vehicle battery, according to which the voltage vbat is converted into a digital value nbat by an analog-to-digital converter (3) with which a reference voltage vref is associated. A standard voltage vo coming from a standard voltage source (11) is, furthermore, delivered regularly to the analogue-to-digital converter, and the voltage vo is converted into a digital value nvo, then a digital value ncor representing the value of the voltage vbat is computed, such that ncor=co×(nbat/nvo), where co=ncor_max×(2n/vbat_max)×(vo/vref), ncor_max being a value selected for coding the maximum value of ncor, nbat_max a digital value resulting from the conversion of the maximum voltage vbat_max to be measured, and n the number of bits of the analog-to-digital converter..
Continental Automotive Gmbh


03/03/16
20160061891 

Mixed mode integrated circuit, providing a controllable test clock signal to a sub-circuitry of the mixed-mode integrated circuit and detecting current paths causing violations of electromagnetic compatibility standards in the mixed mode integrated circuit


A mixed mode integrated circuit, a method of providing a controllable test clock signal to a sub-circuitry of the mixed-mode integrated circuit and a method of detecting current paths causing violations of electromagnetic compatibility standards in the mixed mode integrated circuit are provided. The mixed mode integrated circuit 100 comprises in addition to a clock network 110 an integrated test clock signal generator 140 to generate test clock signals that are provided via controllable multiplexers 150, 160 to an analogue and digital sub-circuitry, respectively, of the mixed-mode integrated circuit.
Freescale Semiconductor, Inc.


03/03/16
20160061867 

Method and metering a voltage signal


A voltage metering module for metering a voltage signal at least one analogue to digital converter (adc) component arranged to receive at an input thereof a voltage signal and to generate a digital signal representative of the received voltage signal. The at least one adc component includes at least one sampling network controllable to sample the received voltage signal for conversion to a digital signal representative of the received voltage signal and at least one compensation network operably coupled in parallel with the sampling network and controllable to sample the received voltage signal such that an input current of the compensation network at least partially compensates for a component of an input current of the sampling network..
Freescale Semiconductor, Inc.


03/03/16
20160060627 

Pharmaceutical composition for inhibition of disease-inducing micrornas


The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 17 nucleobases which are complementary to human micrornas. The short oligonucleotides are particularly effective at alleviating mirna repression in vivo.
Roche Innovation Center Copenhagen A/s


03/03/16
20160058683 

Hair-straightening compositions and methods


A hair-straightening complex consisting essentially of (i) at least one glyoxyloyl derivative formed by reacting glyoxylic acid with at least one alpha, beta or gamma amino acid and/or an amino acid analogue, where the amino acid, or analogue thereof, is not derived from an animal source, (ii) at least one organic acid, (iii) optionally, at least one humectant, and (iv) at least one monoalkyl or dialkyl ether of sorbitol or 1,4-dianhydrosorbitol. A method of straightening hair comprising the steps of applying the above hair-straightening complex to the hair and applying a force generally perpendicular to the length of the hair using a flat surface heated at a temperature of from about 380° f.
Cosphatech Llc


02/25/16
20160056869 

Method and device for sending user-specific reference signal


Disclosed are a method and device for sending a user-specific reference signal. The method provided in the present invention includes: determining a modulus identification, and performing interference elimination processing on a user-specific reference signal according to the modulus identification to obtain the user-specific reference signal after the interference elimination processing; performing beamforming processing on the user-specific reference signal after the interference elimination processing to obtain a beamforming reference signal; and performing inverse fast fourier transform (ifft) and digital-analogue conversion on the beamforming reference signal to obtain an analogue signal of the user-specific reference signal, and sending the analogue signal to a user terminal..
Huawei Technologies Co., Ltd.


02/25/16
20160052873 

Novel intermediate used for preparing tapentadol or analogues thereof


The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula i or ii, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof.
Anhui New Star Pharmaceutical Development Co., Ltd


02/25/16
20160052866 

Novel intermediate used for preparing tapentadol or analogues thereof


The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula i or ii, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof.
Anhui New Star Pharmaceutical Development Co., Ltd.


02/25/16
20160051625 

Cyclosporin analogues for preventing or treating hepatitis c infection


The present invention relates to cyclosporin analogues having antiviral activity against hcv and useful in the treatment of hcv infections. More particularly, the invention relates to novel cyclosporin analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds..
Enanta Pharmaceuticals, Inc.


02/25/16
20160051526 

The local treatment of inflammatory ophthalmic disorders


The present invention provides nalidixic acid and analogues of nalidixic acid, pharmaceutical compositions including at least one of nalidixic acid and analogues of nalidixic acid, and methods for treating inflammatory ophthalmic disorders by local administration. The ophthalmic disorders may be characterized by ocular inflammation, dry eye disorders, pathological ocular angiogenesis, or retinal or sub-retinal edema..
Cresset Biomolecular Discovery Ltd


02/18/16
20160047916 

Automated methods for suppression of spurious signals


An automated method is provided for suppressing spurious signals in a direct digital synthesized signal. To determine magnitudes of local oscillator (“lo”) feedthrough and image frequency signal components, a digitally synthesized rf signal is digitally analyzed.
Spirent Communications Plc


02/18/16
20160045554 

Method for generating mature beta-like cells


The present invention relates to methods for generating mature insulin-producing β-like cells comprising the steps: (a) isolating, purifying and/or enriching β-cell progenitor cells from a population of cells; (b) differentiation of the β-cell progenitor cells into immature insulin-producing β-like cells; and (c) maturation of the immature insulin-producing β-like cells into mature insulin-producing β-like cells, comprising exposing the immature insulin-producing β-like cells to calcitriol or an analogue thereof. More particularly, the present invention relates to methods for generating mature insulin-producing β-like cells for use in treating diabetes..
The University Of Western Australia


02/18/16
20160045378 

Self-contained electronic device for detecting and alerting of the saturation of a protection layer article for urofecal incontinence


The invention relates to a self-contained electronic device for detecting and alerting of the saturation of a protection layer article used for urofecal incontinence, including at least one self-contained electrical generator module comprising an arrangement of pairs of elements having metal electrodes that are electrically connected to one another and distributed over a predetermined inner area of the article, made of zinc-copper in particular, intended for generating a current upon contact with an acidic and aqueous urofecal medium by means of a redox reaction, in order to electrically control, in a self-contained manner, the inner and outer means for giving notification of the saturation, in particular light means, sound means, or means for analogue or digital transmission of wired or wireless signals. The invention is useful in a protection layer article for urofecal incontinence for seniors or infants..

02/11/16
20160043730 

Umformerschaltung mit einer stromschnittstelle sowie meßgerät mit einer solchen umformerschaltung


A converter circuit serves to transform a digital measuring signal representing the chronological sequence of a periodically changing physical and/or chemical measurand into an analogue measure value signal dependent on the digital measuring signal with a signal current, an amperage of which represents a measuring value for the measurand. For this purpose the converter circuit comprises a current interface with a control input, with a current signal output and a current output.
Endress+hauser Flowtec Ag


02/11/16
20160041008 

Non-contact potentiometer


The present invention relates to a non-contact potentiometer. The non-contact potentiometer comprises the following parts: a mechanical housing with through-holes; a rotating shaft comprising a top end and a magnet end on which a permanent magnet is fixed and external torque can be applied to the top end, thus driving the rotating shaft and the permanent magnet to rotate around a rotation axis and relative to the housing; a magnetoresistive sensor assembly fixed inside the housing, comprising one or more sensor chips, the sensitivity axis of the sensor chips lies in a sensing plane that is perpendicular to the axis of the rotating shaft, and separated from the permanent magnet by a predetermined distance in the direction parallel to the axis of the rotating shaft, said sensors are used for sensing the magnetic variation produced as the permanent magnet rotates with the rotating shaft thereby generating sensing signals; and three electrical connection terminals, namely a ground terminal, a power terminal, and a signal output terminal.
Multidimension Technology Co., Ltd.


02/11/16
20160039781 

Novel analogues of epicatechin and related polyphenols


The present invention provides novel analogues of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.. .
Sphaera Pharma Pvt. Ltd.


02/11/16
20160039734 

Therapeutic curcumin derivatives


Curcumin analogues and methods are provided for treatment of disease.. .
Stc.unm


02/11/16
20160038519 

Administration of karenitecin for the treatment of advanced ovarian cancer, including chemotherapy-resistant and/or the mucinous adenocarcinoma sub-types


The present invention discloses and claims methods and compositions for the treatment of platinum and/or taxane cancer treating agent-resistant/-refractory sub-populations and/or the mucinous adenocarcinoma sub-type of ovarian cancer subjects with the silicon-containing highly lipophilic camptothecin derivative (hlcd), karenitecin (also known as bnp1350; cositecan; 7-[(2′-trimethylsilyl)ethyl]-20(s) camptothecin). The administration of karenitecin by intravenous (i.v.) and/or oral methodologies are also disclosed and claimed.
Bionumerik Pharmaceuticals, Inc.


02/11/16
20160037773 

Diindol-3-ylmethanes as potent non-toxic antifouling compounds


The present invention provides high potency 3,3′-diindolylmethane (dim) and analogue compounds as antifouling agents. The present invention further provides methods of preventing or reducing settlement and/or fouling of marine fouling organisms on surfaces of submerged objects by coating the surfaces with the 3,3′-diindolylmethane (dim) and analogue compounds provided..
Hong Kong University Of Science And Technology


02/04/16
20160036461 

Sorting decoder


A sorting decoder captures the rank-order of a set of input analogue signals in the digital domain using simple logic components such as self-timed first state elements, without requiring conventional analogue-to-digital signal converters. The analogue signals are each compared against a monotonic dynamic reference and the resulting comparisons are snapshot by a self-timed first state element for each input signal, or the last member of a sorted collection of input signals, at the time when it reaches the reference signal, so that a different snapshot representing the signal value ranking relative to the other signal values is produced for each input signal.
Kandou Labs S.a.


02/04/16
20160033529 

Use of akt phosphorylation as a biomarker for prognosing neurodegenerative diseases and treating same


The present invention relates to uses of a peptide comprising an amino acid sequence selected from the group consisting of seq id no: 1, seq id no: 2, analogues and derivatives thereof, for the treatment of neurodegenerative diseases, such as amyotrophic lateral sclerosis (als). The present invention further provides a method for assessing responsiveness to treatment with the peptide of the invention.
Yeda Research And Development Co. Ltd.


02/04/16
20160032377 

Modified polymerases for improved incorporation of nucleotide analogues


Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.. .
Illumina, Inc.


02/04/16
20160032257 

Agent and modifying the 5' cap of rna


An agent and method for modifying the 5′ cap of rna, for example for the purposes of isolation and analysis. According to one aspect the invention provides modified enzymes, namely modified trimethylguanosine synthases 2 from giardia lamblia (glatgs2), the enzymatic activity of which is changed such that as compared to wild type enzymes the former can use adomet analogues better as cofactors..
UniversitÄt Hamburg


02/04/16
20160031918 

Photoresponsive nucleotide analogue having photocrosslinking ability


The present invention provides a new photoreactive compound which can be used in technologies for photoreactions of nucleic acid, and also provides a photoreactive crosslinking agent comprising the above photoreactive compound. A photoreactive compound represented by the following formula i can be used..
Japan Advanced Institute Of Science And Technology


02/04/16
20160031795 

Curcumin analogues as zinc chelators and their uses


Wherein α, β, x, y, and r1-r11 are defined herein. This invention also provides a pharmaceutical composition comprising the above compounds, a method of inhibiting the activity and/or levels of a matrix metalloproteinase (mmp), a method of inhibiting the production of a cytokine in a population of cells, a method of inhibiting the production of a growth factor in a population of cells, and a method of inhibiting nfκ-b activation in a population of cells..

02/04/16
20160030358 

Solid dosage form of coated bisphosphonate particles


A solid dosage form comprises coated particles of bisphosphonate or a pharmaceutically acceptable analogue or derivative thereof.. .
Arrow International Limited


02/04/16
20160029643 

Methods, compounds and compositions for repelling insects and/or arachnids


The present specification discloses natural repellent compounds, and isomeric forms, structural analogues and derivatives of the said compounds, having repellent activity against mosquitoes and other blood-sucking arthropods, compositions comprising such repellent compounds, methods of screening for such repellent compounds, methods of reducing mosquito bites on an individual and methods of reducing mosquito infestation to a location.. .
National Center For Scientific Research "demokritos"


02/04/16
20160029626 

Cysteine amino-acid compound (or its analogues) used in the disruption of microbial biofilms when treating or preventing diseases caused by phytopathogenic bacteria known to attack plants of agricultural interest


“cysteine amino-acid compound (or its analogues) used in the disruption of microbial biofilms by treatment of prevention of diseases generated by phytopathogenic bacteria attacking plants of agricultural interest” represented by an innovative solution within the agriculture sector, where said compound can be used in the pharmacological form, as a drug associated with fertilizer for the combat of bacterial diseases which form microbial biofilms, such as citrus variegated chlorosis (cvc), citric canker', huanlongbing (hlb) disease or ‘greening’, amongst other, which inventive concept, as such, never before completed, resides in the benefit deriving from the cysteine amino-acid, and all of its analogues, in the inhibitory action and progressive disruption of the microbial biofilm thus liberating the nutritive flux and hydration of the root to the upper part of the plant and the subsequent regression of the disease symptoms, with the added advantage that the cysteine amino-acid compound is non-toxic, guaranteeing healthy production of foods by plants of agricultural interest that are totally healthy, without toxic residues in their composition, as well as when said compound is applied there is risk to the environment due to the rapid absorption, notably within the area in which it is applied, where such predicates of disease combat, with the exception of toxic collateral effects still guarantee that the final crop and harvest will have a higher productivity per hectare.. .
Instituto Agronomico De Campinas - Iac


01/28/16
20160028454 

Method and facilitating high data rate transmission in the wireless communication


A method for a wireless device capable of receiving and transmitting a signal includes receiving a reference signal from a second wireless device through a communication channel, estimating the communication channel, using the reference signal, selecting a pair of an analogue digital converter (adc) quantizer and an input distribution, based on the estimated communication channel, and sending information on the selected input distribution and the adc quantizer to the second wireless device. A wireless device capable of wirelessly receiving and transmitting a signal includes a transceiver configured to receive a reference signal from a second wireless device through a communication channel, and a processor configured to estimate the communication channel, using the reference signal, selecting a pair of an adc quantizer and an input distribution, based on the estimated communication channel, and sending information on the selected input distribution and the adc quantizer to the second wireless device..
Samsung Electronics Co., Ltd.


01/28/16
20160028380 

Signal processing


A method of processing an amplitude-modulated analogue signal at a carrier frequency fc comprises: digitising the analogue signal to produce an input bit stream that represents the amplitude of the analogue signal; generating an in-phase reference bit stream that is synchronous to the carrier frequency fc and represents an in-phase digital reference signal substantially in the form of a sine and/or cosine wave; and multiplying the input bit stream with the in-phase reference bit stream to produce an output bit stream representing the amplitude modulation of the analogue signal.. .
Atlantic Inertial Systems Limited


01/28/16
20160028300 

Inverter assembly without galvanic isolation


Disclosed is an inverter assembly without galvanic isolation, the inverter assembly including a pcb mounted with a power supply circuit unit, an inverter unit, an analogue circuit unit and a controller, a first ground circuit pattern to supply a ground power to the power supply circuit unit and the inverter unit, a second ground circuit pattern to supply the ground power to the analogue circuit unit, a third ground circuit pattern to supply the ground power to the controller, a first bead between the first ground circuit pattern and the second ground circuit pattern to isolate an impedance between the first ground circuit pattern and the second ground circuit pattern, and a second bead between the second ground circuit pattern and the third ground circuit pattern to isolate an impedance between the second ground circuit pattern and the third ground circuit pattern.. .
Lsis Co., Ltd.


01/28/16
20160028028 

Tetradentate platinum (ii) complexes cyclometalated with functionalized phenyl carbene ligands and their analogues


Tetradentate platinum complexes of formulas i and ii suitable for phosphorescent or delayed fluorescent and phosphorescent emitters in display and lighting applications.. .
Arizona Board Of Regents On Behalf Of Arizona State University


01/28/16
20160024574 

Dna sequencing with non-fluorescent nucleotide reversible terminators and cleavable label modified nucleotide terminators


This invention provides a process for sequencing nucleic acids using 3′ modified deoxynucleotide analogues or 3′ modified deoxyinosine triphosphate analogues, and 3′ modified dideoxynucleotide analogues having a detectable marker attached to a base thereof.. .
The Trustees Of Columbia University In The City Of New York


01/28/16
20160024061 

Preparation of 2'-fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives


The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-d-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-hcv activity, and their analogues, and (iii) methods to prepare the anti-hcv nucleosides containing the 2′-deoxy-2′-fluoro-2′-c-methyl-b-d-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.. .
Gilead Pharmasset Llc


01/28/16
20160022645 

Desferrithiocin polyether analogues


A salt, hydrate or solvate thereof; and methods and compositions for treating the effects of trivalent metal, i.e., iron, overload.. .

01/28/16
20160022622 

Lipid compositions containing bioactive fatty acids


Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of structured lipid compositions containing sciadonic and/or pinoleic acid alone or in combination with other bioactive fatty acids including, but not limited to, eicosapentaenoic acid, docosahexaenoic acid, conjugated linoleic acid, and non-β-oxidizable fatty acid analogues such as tetradecylthioacetic acid.. .

01/21/16
20160020742 

Method for digitally compensating variations, as a function of temperature, of an electrical quantity of an embedded space radiofrequency telecommunications equipment item


A digital compensation method includes measuring the temperature of the equipment item and applying an analogue control voltage intended to maintain the electrical quantity of the equipment item at a predetermined setpoint value. At each measurement instant, the method includes interrogating look-up tables respectively associated with different setpoint values, then, when the measured temperature is situated between two digital temperature states stored in the look-up tables, creating intermediate digital temperature states situated between the two stored digital temperature states, computing, by interpolation, digital control words corresponding to the intermediate digital temperature states created, and selecting a digital control word, stored or intermediate, corresponding to the measured temperature, then delivering, to at least one of the n individual devices, the analogue control corresponding to the selected digital control word..
Thales


01/21/16
20160015784 

Mic-1 fusion proteins and uses thereof


The invention relates to mic-1 fusion proteins. More specifically it relates to compounds comprising fusion proteins comprising a mic-1 protein or an analogue thereof at the c-terminus of the fusion protein and a functional variant of human serum albumin at the n-terminus of the fusion protein connected via a peptide linker.
Novo Nordisk A/s


01/14/16
20160013835 

Multi-stage equalisation use in telemetry


The present invention relates to inspection apparatus for use in wellbores in the oil and gas industries. In particular the invention relates in general to the field of transmission of data between downhole module in a wellbore and a controlling module at the surface.
E.v. Offshore Limited


01/14/16
20160011014 

Electronic measurement circuit


The present invention concerns an electronic measurement circuit for measuring a physical parameter. The circuit comprises: a measurement sensor comprising two differential mounted capacitors each comprising a fixed electrode, and a common electrode, common to the two capacitors which is arranged to be movable relative to each fixed electrode of the two capacitors in order to alter the capacitive value of each capacitor when the physical parameter is measured.
Em Microelectronic-marin Sa


01/14/16
20160009777 

Glucagon analogues


The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods.
Zealand Pharma A/s


01/14/16
20160008287 

Micronized insulin, micronized insulin analogues, and methods of manufacturing the same


A method of preparing an inhalable insulin suitable for pulmonary delivery includes: dissolving an insulin raw material in an acidic solution to form a dissolved insulin solution; titrating the dissolved insulin solution with a buffer solution to form a suspension comprising micronized insulin particles; and stabilizing the micronized insulin particles.. .
Amphastar Pharmaceuticals Inc.


01/07/16
20160006375 

Device for controlling a nozzle of variable cross-section of an aircraft


The invention relates to a control device of a nozzle of variable cross-section of an aircraft suitable for providing a three-phase ac electrical power supply, the nozzle of variable cross-section comprising one or more movable parts which make it possible to modify the cross-section of the nozzle, the control device comprising a system for regulation of the engine connected to a control element which drives at least one electric motor which by a mechanical transmission system creates the movement of the movable part or parts, wherein the electric motor is configured to use directly the electrical power supply of the aircraft and in that the control element comprises analogue type structure to switch the phases of the electrical power supply to modify the direction of rotation of the electric motor.. .
Airbus Operations (s.a.s.)


01/07/16
20160004900 

Method for forming an image reference device


A method is provided of forming an imaging reference device for a biological material imaging system. A first region is provided in a substrate formed from an optically transmissive material which is an analogue of biological tissue.
Ffei Limited


01/07/16
20160003951 

Device for processing a signal delivered by a radiation detector


The invention relates to a device for processing information delivered by a photon detector, comprising: an analogue circuit for generating a signal comprising a series of pulses, each pulse having an amplitude proportional to the energy freed by an interaction of a photon in the detector; an analogue circuit for determining the instant at which the amplitude of a pulse of the signal is maximal; and an element for capturing the value of the signal at said instant.. .
Commissariat à I'Énergie Atomique Et Aux Énergies Alternatives


01/07/16
20160003880 

Method for measuring a physical parameter and electronic circuit for implementing the same


The physical parameter measurement method is performed using an electronic circuit (1) with a resistive sensor (2). The resistive sensor includes two resistors (r1, r2) mounted in series, whose connection node connected to a moving mass (m), is connected to a first input of an amplifier-comparator (3).
Em Microelectronic-marin Sa


01/07/16
20160002311 

Novel glucagon analogues


The present invention relates to novel peptide compounds which have a protracted profile of action and improved solubility and stability, to the use of the compounds in therapy, to methods of treatment comprising administration of the compounds to patients in need thereof, and to the use of the compounds in the manufacture of medicaments. The compounds of the invention are of particular interest in relation to the treatment of hyperglycemia, diabetes and obesity, as well as a variety of diseases or conditions associated with hyperglycemia, diabetes and obesity..
Novo Nordisk A/s


01/07/16
20160002273 

Thieno[3,2-d]pyrimidine-6-carboxamides and analogues as sirtuin modulators


Provided herein are novel substituted thieno[3,2-d]pyrimidine-6-carboxamide sirtuin inhibitors and methods of use thereof. The sirtuin inhibitors may be used for inhibiting a sirtuin-mediated biological process, and, e.g.
Glaxosmithkline Llc


01/07/16
20160002193 

Anticancer compounds and process for the preparation thereof


The invention disclosed herein relates to novel peribysin e analogues of general formula-i. Further the invention provides simple, economical and short synthesis of peribysin e and its analogues of formula i, in good yield and purity leading to the identification of more potent cell adhesion inhibitors..
Council Of Scientific And Industrial Research


01/07/16
20160002159 

Perfluoro-tert-butyl hydroxyproline


The present invention provides novel analogues of alpha amino acids, comprising a perfluoro-tert-butyl group, and molecules comprising the novel analogues. Also provided are a wide range of applications of the novel analogues in therapeutics, theranostics and pharmaceuticals as well as in imaging applications.

01/07/16
20160000929 

Polymer conjugate for delivery of a bioactive agent


The presentinvention relates in general to polymer-bioactive agent conjugates for delivering a bioactive agent to a subject. The polymer-bioactive agent conjugates contain triazole moieties in the polymer backbone and a bioactive moiety selected from prostaglandin analogues, β-blockers and mixtures thereof.
Polyactiva Pty Ltd


01/07/16
20160000883 

Combination of acylated glucagon analogues with insulin analogues


The invention relates to methods for treating metabolic disorders, including diabetes by using a combination of an acylated glucagon analogue and an insulin analogue. The invention also features a kit that includes an acylated glucagon analogue and an insuline analogue..
Zealand Pharma A/s


01/07/16
20160000796 

Pharmaceutical composition for use in prevention or treatment of cancer


Abacavir, a nucleoside analogue reverse transcriptase inhibitor, has been found to exhibit an anti-cancer activity on atl cells in vitro without inhibiting dna replication of normal cells. Abacavir or a pharmaceutically acceptable derivative thereof is useful as an active ingredient of a pharmaceutical composition for use in the prevention or the treatment of cancer, in particular a cancer whose dna repair system is impaired such as breast cancer or adult t-cell leukemia..
Kyoto University


01/07/16
20160000749 

Method of inhibiting or treating a dengue virus infection with quercetin


The present invention relates to a composition having antiviral activity for prophylaxis or treatment of flavivirus infection or a disease resulting therefrom in humans or animals, characterised in that the composition comprises quercetin, or analogues, or derivatives thereof. The composition may further comprise a pharmaceutically acceptable carrier.
Universiti Malaya


01/07/16
20160000746 

Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues


Pharmaceutical compositions and methods for treating and/or preventing age-related macular degeneration with melatonin analogues are provided.. .
Takeda Pharmaceutical Company Limited


12/31/15
20150381198 

Apparatus and monitoring electrical current


An apparatus for sensing current of a vehicle battery employs an extended counting analogue-to-digital conversion process to a chopped and amplified voltage appearing across a low ohmic shunt resistor placed between the negative pole of the vehicle's battery and the chassis ground of the vehicle. Gain adjustment control of a programmable gain amplifier by matching the gain to the dynamic range of the adc permits a high dynamic signal sensing..
Freescale Semiconductor, Inc.


12/31/15
20150381185 

Circuit arrangement and calibrating activation signals for voltage-controlled oscillators


In order to develop a circuit arrangement (100) and also a method for calibrating at least one activation signal (vbb) provided for a voltage-controlled oscillator (10) such that the expenditure of energy is as low as possible and the output frequency is as high as possible, it is proposed—that the respective number of clock cycles (n) for at least one calibration oscillator (50) and at least one reference oscillator (30) associated with the calibration oscillator (50) is counted by means of at least one clock cycle counter (70) connected downstream of the calibration oscillator (50) and the reference oscillator (30) and a clock error (de) resulting from the difference between these two numbers of clock cycles (n) is integrated and—that the clock error (de) is converted by means of at least one digital-to-analogue converter (90) connected downstream of the clock counter (70) into analogue tuning signals (vcm, vcm−, vcm+) from which the calibrated activation signal (vbb) is derived.. .
Silicon Line Gmbh


12/31/15
20150376582 

Modified polymerases for improved incorporation of nucleotide analogues


Presented herein are polymerase enzymes for improved incorporation of nucleotide analogues, in particular nucleotides which are modified at the 3′ sugar hydroxyl, as well as methods and kits using the same.. .
Illumina, Inc.


12/31/15
20150376257 

Glucagon analogues


The invention provides materials and methods for promoting weight loss or preventing weight gain and for treating diabetes and associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptide compounds effective in such methods.
Zealand Pharma A/s


12/31/15
20150376254 

Gamma-msh analogues


The present invention provides peptide analogues of γ-msh, comprising the amino acid sequence of human γ-msh, or variants thereof, and having one or two linear amino acid probe(s) in the n- and/or c-terminal part of the peptide.. .
Txp Pharma Gmbh


12/31/15
20150376236 

Peptidomimetics possessing photo-controlled biological activity


The present invention relates to pharmaceutically and/or diagnostically active compounds, in particular peptide analogues (peptidomimetics), which can be reversibly controlled between an active and an inactive state by irradiation with light of different wavelengths. The present invention further relates to an intermediate compound usable in the manufacture of such pharmaceutically and/or diagnostically active compounds, as well as a manufacturing method thereof..
National Taras Shevchenko University Of Kyiv


12/31/15
20150376219 

Selective preparations of purine nucleosides and nucleotides: reagents and methods


A process of regiospecific synthesis of n-9 purine nucleoside analogs in either solution or solid phase synthesis is described. The introduction of the sugar moiety or its analogue on to a 6-heteroarylium purine or its mesomeric betaine so that formation of only the n-9 position regioisomers of the purine nucleoside analogs (either d or l enantiomers) is obtained.

12/31/15
20150376201 

Cortistatin analogues and syntheses thereof


And salts thereof, wherein r1, r2, r3, r4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin a, j, k, and l, and analogs thereof.. .

12/31/15
20150376197 

Morphan and morphinan analogues, and methods of use


The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.. .
Alkermes Pharma Ireland Limited


12/31/15
20150374795 

O-glycosylated carboxy terminal portion (ctp) peptide-based insulin and insulin analogues


Compositions and formulations comprising insulin or insulin analogues comprising a carboxy terminal portion (ctp) peptide comprising amino acids 112-188 to 142 of the beta subunit of human chorionic gonadotropin (hcgβ) or a partial variant thereof that includes at least one o-glycosylation site of the ctp peptide, wherein the ctp peptide of the ctp peptide-based insulin or insulin analogue is o-glycosylated are described. In particular embodiments, the o-glycosylated insulin analogues are produced in vivo and in further embodiments, the o-glycosylated ctp-based insulin analogues comprise predominantly mannotriose and mannotetrose o-glycans or predominantly mannose o-glycans..
Indiana University Research And Technology Corporation


12/31/15
20150374704 

Combined systemic and topical treatment of disordered and/or prodromal stage tissue


Compositions and methods for treating disordered and/or prodromal stage tissue infected with by a virus in a mammal by co-administering a systemic anti-virus drug and topically administered anti-infective composition. The systemic anti-virus drug is internally administered and disrupts or inhibits virus replication systemically within the mammal.
Quadex Pharmaceuticals, Llc




Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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