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This page is updated frequently with new Analogue-related patent applications. Subscribe to the Analogue RSS feed to automatically get the update: related Analogue RSS feeds. RSS updates for this page: Analogue RSS RSS


System and method for acquisition of biopotential signals with motion artifact reduction

Imec Vzw

System and method for acquisition of biopotential signals with motion artifact reduction

System and method for acquisition of biopotential signals with motion artifact reduction

Ipsen Pharma S.a.s.

Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal

Date/App# patent app List of recent Analogue-related patents
06/25/15
20150180650
 Synchronisation  for transmit and receive symbols of all-digital receiver patent thumbnailnew patent Synchronisation for transmit and receive symbols of all-digital receiver
A synchronisation method and device for transmit and receive symbols of an all-digital receiver. The method comprises the steps of: after receiving a sampling signal sent by a baseband processing chip, the clock signal of which is provided by a second clock source, a digital signal processor (dsp), the clock signal of which is provided by a first clock source, measuring a phase shift between a local sampling symbol and an air interface symbol, and acquiring the phase shift amount; according to the phase shift amount, adjusting a sampling opportunity for the sampling of a digital-analogue/analogue-digital converter; and when the sampling opportunity for the sampling of the digital-analogue/analogue-digital converter has been adjusted, adjusting an interface clock for data transmitting and receiving of the dsp so as to enable the data transmitting and receiving of the dsp to be synchronised with the sampling..
Hytera Communications Corp., Ltd.
06/25/15
20150180496
 Phase estimator patent thumbnailnew patent Phase estimator
A phase estimator comprising a first input terminal configured to receive a first analogue input signal; a second input terminal configured to receive a second analogue input signal, wherein the second analogue input signal is 90° out of phase with the first analogue input signal. The phase estimator is configured to provide a digital word representative of the phase of the first analogue input signal and the second analogue input signal.
Nxp B.v.
06/25/15
20150180495
 Converter arrangement and  converting an analogue input signal into a digital output signal patent thumbnailnew patent Converter arrangement and converting an analogue input signal into a digital output signal
The invention relates to an arrangement and a method for the identification of parameters in a nonlinear model of an analog-to-digital converter (adc 17) and the use of this information to reduce the nonlinear distortions of the adc. A parameter estimator determines an ad parameter vector pad which describes the nonlinearities of the adc (17).
06/25/15
20150175665
 Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal patent thumbnailnew patent Analogues of glucose-dependent insulinotropic polypeptide (gip) modified at n-terminal
There is provided a novel series of analogues of glucose-dependent insulinotropic polypeptide, pharmaceutical compositions containing said compounds, and the use of said compounds as gip-receptor agonists or antagonists for treatment of gip-receptor mediated conditions, such as non-insulin dependent diabetes mellitus and obesity.. .
Ipsen Pharma S.a.s.
06/25/15
20150175645
 Nicotinamide riboside and analogues thereof patent thumbnailnew patent Nicotinamide riboside and analogues thereof
Provided herein are sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing.
Glaxosmithkline Llc
06/25/15
20150175587
 Synthesis of epothilones, intermediates thereto and analogues thereof patent thumbnailnew patent Synthesis of epothilones, intermediates thereto and analogues thereof
As described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (i) and provides methods of treating cancer comprising administering a compound of formula (i)..
06/25/15
20150174232
 Composition and uses thereof patent thumbnailnew patent Composition and uses thereof
An immunogenic composition comprising the nm-acp protein or an immunogenic part thereof or an analogue thereof, wherein the composition is capable of eliciting an immune response when administered to a human or non-human animal.. .
University Of Southampton
06/25/15
20150174095
 Pharmaceutical compositions for the treatment of visual system disorders patent thumbnailnew patent Pharmaceutical compositions for the treatment of visual system disorders
The present invention relates to pharmaceutical compositions comprising d-serine transporter inhibitors which are proline analogues and therapeutic methods using such pharmaceutical compositions in methods for the treatment of visual system disorders and the enhancement of the visual function.. .
Allergan, Inc.
06/25/15
20150173683
 System and  acquisition of biopotential signals with motion artifact reduction patent thumbnailnew patent System and acquisition of biopotential signals with motion artifact reduction
A biopotential signal acquisition system including an analogue readout unit configured to receive an analogue biopotential signal, which may be acquired from at least one electrode attached to a body; and to extract an analogue measured biopotential signal and an analogue reference signal. The system also includes an adc unit configured to provide a digital version of the analogue measured biopotential signal and the analogue reference signal, a digital filter unit configured to calculate a digital motion artifact estimate based on the digital version of the measured biopotential signal and the reference signal.
Imec Vzw
06/18/15
20150168917
 Control  an analogue display fitted to a timepiece movement patent thumbnailControl an analogue display fitted to a timepiece movement
In a backward direction, in accelerated mode, during a second period following the first period, before the periodic actuation wheel set is driven in a position of its area of actuation.. .
06/18/15
20150166990

Therapeutic oligonucleotides comprising pyrazolotriazine nucleotide analogues


Disclosed herein are double-stranded rna nucleic acid molecules, which include at least one pyrazolotriazine nucleotide analogue and have been modified to exhibit one of the following, increased on-target activity, increased target specificity, enhanced nuclease stability, reduced off target activity and/or reduced immunogenicity when compared to an unmodified or similarly modified dsrna; pharmaceutical compositions comprising such molecules and methods of use thereof in therapy.. .
Qbi Enterprises Ltd.
06/18/15
20150166625

Exendin-4 peptide analogues


The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake. .
Sanofi
06/18/15
20150166513

Heterocyclyl pyrimidine analogues as tyk2 inhibitors


Wherein r, r1, x1 to x5 have the meaning as cited in the description and the claims. Said compounds are useful as tyk2 inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases.
06/18/15
20150165139

Intranasal administration


Intranasal administration of proteins, such as insulin and insulin analogues, in particular immunogenic proteins to the upper posterior region of a nasal cavity of a subject, and in particular the olfactory bulb region.. .
Optinose As
06/18/15
20150165046

Compositions comprising sphingosine 1 phosphate (s1p) receptor modulators


The present invention relates to stable compositions comprising a sphingosine 1 phosphate (s1p) receptor modulator, suitable for use as a dosage form. The s1p receptor modulators are typically sphingosine analogues, such as 2-substituted 2-amino-propane-1,3-diol or 2-amino-propanol derivatives, e.g.
Novartis Ag
06/18/15
20150164998

Insulin analogue or its pharmaceutically acceptable salt, pharmaceutical composition with prolonged therapeutic effect, use of the insulin analogue, dosage method and treatment of diabetes


The invention relates to an insulin analogue or its pharmaceutically acceptable salt, pharmaceutical composition with prolonged therapeutic effect, application of the insulin analogue, dosage method and method of treatment of diabetes. In more detail, the solution pertains to compounds being stable insulin analogues which are pharmaceutically active and characterised by a prolonged, flat, truly peakless course of glucose concentration vs.
Instytut Biotechnologii I Antybiotykow
06/18/15
20150164996

Non-acylated exendin-4 peptide analogues


The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake.. .
Sanofi
06/18/15
20150164995

Exendin-4 peptide analogues as dual glp-1/gip agonists


The present invention relates to exendin-4 derivatives and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, as well as reduction of excess food intake. .
Sanofi
06/18/15
20150164992

Methods and compositions for promoting organ growth and development


Methods and compositions are provided for promoting organ development in warm blooded animals, and in particular in certain aspects a premature infant or foetus. Compositions and methods are also provided for the administration of at least one colony stimulating factor-1 protein (csf-1), precursor, variant, analogue, derivative thereof, or combinations thereof, or otherwise, at least one nucleic acid molecule encoding colony stimulating factor-1 protein (csf-1), precursor, variant, analogue, derivative thereof, or combinations thereof..
Kintan Pty Ltd.
06/18/15
20150164921

Chemoprevention of colorectal cancer


In the present invention, a new combination is disclosed comprising (i) 5-aminosalicylic acid (5-asa) or a derivative thereof, or a pharmacologically acceptable salt thereof, and (ii) a group d vitamin, a derivative thereof, a metabolite or analogue, for use in the prevention and/or treatment of colorectal cancer (crc). A further aspect of the invention is directed to pharmaceutical compositions comprising said combination together with at least one physiologically acceptable excipient and the use thereof in the prevention and/or in the treatment of the colorectal cancer..
Lga Biotecnologie S.r.l.
06/18/15
20150164826

Dosage forms and related therapies


This invention is directed in part to novel doses, dosage formulations, and routes of administration of such doses and dose formulations, said dose and dose formulations containing one or more copper chelators, for example, one or more trientine active agents, including trientine analogues, trientine salts, trientine prodrugs, and trientine derivatives, useful in the treatment of diseases, disorders and conditions, including in indications where copper may play a role.. .
Philera New Zealand Limited
06/18/15
20150164107

Frozen dessert mixes using pulse protein products


Pulse protein products having a protein content of at least about 60 wt % (n×6.25) d.b., preferably at least about 90 wt %, and being soluble at ph values of less than about 4.4 and heat stable at such ph values, or alternatively adjusted in ph to a ph of about 6 to about 8 and further processed by drying the product, recovering and drying any precipitated pulse protein material, heat treating and then drying the product, or heat treating the product and recovering and drying any precipitated pulse protein material are used to provide, at least in part, the protein component of a dairy analogue, dairy alternative or plant/dairy blend frozen dessert mix.. .
Burcon Nutrascience (mb) Corp.
06/11/15
20150158864

Pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl and pyr-rolo[2,3-d]pyridinyl acrylamides


The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl and pyrrolo[2,3-d]pyridinyl acrylamides and analogues thereof. Such compounds are useful for inhibiting janus kinase (jak).
Pfizer Inc.
06/11/15
20150158841

Curcumin analogs


Provided herein are curcumin analogues that are able to interact with amyloid β (aβ) and to attenuate the copper-induced crosslinking of aβ. Also provided herein are methods of using the compounds in the treatment of alzheimer's disease or a related disorder..
The General Hospital Corporation
06/11/15
20150157642

Cosmetic changing the appearance of eyes


The current application is directed to cosmetic methods for changing the appearance of eyes by causing a retraction of the eyelids so that the eyes appear to be more open and have a wider appearance. Various methods involve application of one or more prostaglandins, synthetic prostaglandins, including synthetic prostaglandin f, and synthetic prostaglandin analogues, to eyelids, which results in contraction of eyelid muscles and a wider, more open appearance of the eyes..
06/11/15
20150157580

Methods of regulating cannabinoid receptor activity-related disorders and diseases


This disclosure concerns the discovery of the use of fenoterol analogues for regulating cannabinoid (cb) receptor activity-related disorders and disease, such as dysregulated cb receptors, including treating a disorder or disease, such as a glioblastoma, hepatocellular carcinoma, liver cancer, colon cancer, and/or lung cancer, which is associated with altered cannabinoid receptor activity. In one example, the method includes administering to a subject having or at risk of developing a disorder or disease regulated by cb receptor activity an effective amount of a fenoterol analogue to reduce one or more symptoms associated with the disorder or disease regulated by cb receptor activity..
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services
06/04/15
20150153712

Method for displaying a trend over a timing operation and associated timepiece


Portable timepiece including an hour hand and a minute hand for the current time display, rotating about a central wheel facing a bezel, and also a chronograph module, wherein the timepiece further includes a first analogue trend indicator relating to a measured time interval.. .
Eta Sa Manufacture Horlogere Suisse
06/04/15
20150153344

Coelenterazine analogues and coelenteramide analogues


Coelenterazine analogues with different luminescence properties from conventional ones and coelenteramide analogues with different fluorescence properties from conventional ones have been desired. The invention provides coelenterazine analogues modified at the 8-position of coelenterazine and coelenteramide analogues modified at the 2- or 3-position of coelenteramide..
National University Corporation Tokyo Medical And Dental University
06/04/15
20150150968

Use of cd28-specific monoclonal antibodies for producing a pharmaceutical composition for treating virus infections


The invention relates to the use of monoclonal antibodies which are specific for cd28 and activate the t lymphocytes of several up to all subgroups without the occupation of an antigen receptor of the t lymphocytes and which therefor activate said lymphocytes in an antigen unspecific manner or the invention relates to the use of an analogue thereof for producing a pharmaceutical composition in the form of a preparation or a preparation packet for treating virus infections in humans or lower warm-blooded animals having infected t lymphocytes. The pharmaceutical composition additionally contains a virus inhibitor.
Theramab Llc
06/04/15
20150150847

Use of n-acetyl-5-methoxytryptamine or analogues thereof, for promoting the mechanism of implantation of the embryo and related compositions and culture media


The present invention refers to the use of n-acetyl-5-methoxytryptamine (melatonin) and/or an analogue thereof, for use in the medical or veterinary field in the assisted reproduction for promoting the mechanism of implantation of the embryo, and in particular for the prevention of implantation failure into the uterus, by topical administration of an effective amount in a mammalian subject female in need of such treatment, and related compositions, culture media and medical devices.. .
Ares Trading S.a.
06/04/15
20150150483

Device, method and software for measuring exhalation capacity


Measurement device (1) for measuring the exhale capacity of a patient, includes a main body (2) with a through hole (3) with a blowing device (17) which has a rotation device (20) which is put in rotary motion through blowing, with a rotary speed depending on the intensity of the blowing, and the rotation of which is sensed by an optical sensor (6). The measuring device includes a cable (11) which is connected to the main body of the measurement device, and with a free end (11b) which is arranged to be connected to an audio input of a handheld general purpose computer unit (14), and in that the measurement device is arranged to, to the handheld computer unit, continuously deliver an analogue electric signal which carries information about rotary speed or air flow.
Pond Health Care Innovation Ab
05/28/15
20150148524

Amino acid analogues and methods for their synthesis


A method for the synthesis of an amino acid analogue or a salt, solvate, derivative, isomer or tautomer thereof comprising the steps of: (i) subjecting an amino acid containing a metathesisable group to metathesis with a compound containing a complementary metathesisable group of formula (i) or (ii): (formulae (i), (ii)) wherein r1 and r2 are independently selected from h and substituted or unsubstituted c1 to c4 alkyl; each r3 is either absent or independently selected from a heteroatom, a substituted or unsubstituted c1 to c20 alkyl, and a substituted or unsubstituted c1 to c20 alkyl group interrupted by one or more heteroatoms; and each x is independently selected from h and an effector molecule; in the presence of a reagent to catalyse the metathesis to form a dicarba bridge between the amino acid containing a metathesisable group and the compound containing a complementary metathesisable group; and (ii) reducing the dicarba bridge to form a saturated dicarba bridge, wherein the reagent used to catalyse step (i) also catalyses step (ii).. .
Monash University
05/28/15
20150148417

Synthesis and biological studies of an isomeric mixture of (e/z) isoxylitones and its analogues


The invention relates to an anti-epileptic isoxylitone, 2,2′-(3,5,5-trimethyl-2-cylohexen-1-ylidene)acetic acid.. .
05/21/15
20150142085

Pharmaceutical compositions and methods for treating age-related macular degeneration with melatonin analogues


Pharmaceutical compositions and methods for treating and/or preventing age-related macular degeneration with melatonin analogues are provided.. .
Takada Pharmaceuticals U.s.a., Inc.
05/21/15
20150141490

Pyrazolotriazolyl nucleoside analogues and oligonucleotides comprising them


The present invention relates to pyrazolotriazolyl nucleoside analogues, oligonucleotide comprising them, and uses thereof. Further the invention relates to a method for reducing gene expression in a cell comprising transfecting the cell with such an oligonucleotide.
Bio-lab Ltd.
05/21/15
20150141416

Hydroxybupropion analogues for treating drug dependence


The invention provides hydroxybupropion analogues capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes.
Virginia Commonwealth University
05/21/15
20150141352

Bone loss preventing and bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide


The present invention relates to a bone regeneration or bone formation promoting pharmaceutical composition comprising muramyl dipeptide, an analogue thereof, a derivative thereof or a pharmaceutically acceptable salt thereof. In contrast to existing passive therapeutic agents which center on bone absorption suppression based on mechanisms for reducing osteoclast functionality, the composition comprising muramyl dipeptide of the present invention promotes the differentiation of osteoblasts, which are bone forming cells, and can advantageously be used in various diseases where bone formation is required as an active therapeutic agent that does not affect osteoclast..
Snu R&db Foundation
05/21/15
20150141328

Stimulation of human meibomian gland function


Disclosed herein are systems and methods for stimulating meibomian gland epithelial cell function by administering to the ocular surface or immediate vicinity of an eye of a subject an effective amount of a pharmaceutical composition containing a pld-inducing compound, such as the cationic amphiphilic drugs (e.g. Azithromycin), androgen or an androgen analogue with androgen effectiveness, corticosteroid, progesterone, igf-1 or an igf-1 analogue (e.g.
The Schepens Eye Research Institute
05/21/15
20150141255

New strigolactone analogues and the use thereof for the treatment of plants


In which x represents o, s, nh or an n-alkyl radical, r1 and r2, identical or different, each represent h or a c1-c10 hydrocarbon radical, r1 and r2 not both representing h, r3 represents a c1-c10 hydrocarbon radical, and r represents a phenyl radical monosubstituted or disubstituted by a substituent y and, if applicable, a substituent z, chosen from cl, br, i and cf3, or r represents a c═r4(r5) radical in which r4 represents an hydrocarbon radical and r5 represents a linear or branched, saturated or unsaturated, hydrocarbon radical, optionally substituted, a cor6 group or a co2r6 group, where r6 represents a hydrogen atom or a linear or branched, saturated or unsaturated, hydrocarbon radical. This compound can be used for the treatment of higher plants for controlling their growth and architecture..
05/21/15
20150140059

Novel oxysterol analogue, oxy149, induces osteogenesis and hedgehog signaling and inhibits adipogenesis


This invention relates, e.g., to a synthetic compound, oxy149, having the structure (formula i) or a bioactive or pharmaceutical composition comprising oxy149 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g.
University Louisville Research Foundation, Inc.
05/21/15
20150139553

Device for detecting edges and improving the quality of an image


Device for edge detection and quality enhancement in an image which comprises a grouping of identical and locally interconnected elementary processing cells. Each processing cell is characterised in turn by a comparator which carries out in parallel the comparison of each pair of neighbouring pixels.
Consejo Superior De Investigaciones Cientificas
05/21/15
20150139440

Audio interface device


A wireless interface device for at least one of wireless transmission from an electric analogue audio device or wireless reception at an electric analogue audio device of an audio signal, comprises an audio connector jack plug or jack socket in communication with a system that is at least one of a wireless internet system or a wlan-enabled system and connectable to at least one of an audio connector jack plug of the electric analogue audio device, or an audio connector jack socket of the electric analogue audio device.. .
Ingenious Audio Limited
05/14/15
20150133659

(e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one and analogs thereof, as well as preparation method and use thereof


The present invention relates to millepachine ((e)-1-(5-methoxy-2,2-dimethyl-2h-chromen-8-yl)-3-(4-methoxyphenyl)prop-2-en-1-one) and its analogues. The present invention provides methods for preparing these compounds, pharmaceutical compositions including these compounds, and methods of treating diseases utilizing pharmaceutical compositions including these compounds..
05/14/15
20150133479

Pyrimidinylpiperidinyloxypyridone analogues as gpr119 modulators


Novel compounds of structure formula i: (i) or an enantiomer, a diastereomer, or a pharmaceutically acceptable salt thereof, wherein r1, r2 and r3 are defined herein, are provided which are gpr119 g protein-coupled receptor modulators. Gpr119 g protein-coupled receptor modulators are useful in treating, preventing, or slowing the progression of diseases requiring gpr119 g protein-coupled receptor modulator therapy.
05/14/15
20150133462

Methods and compositions for the treatment of bcr-abl positive lymphoblastic leukemias


In one aspect, the invention relates to compositions comprising bcr-abl tyrosine kinase inhibitors and artemisinin analogues, derivatives thereof, or related compounds, which are useful as in treating philadelphia chromosome positive leukemias; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with bcr-abl dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention..
05/14/15
20150133389

Na+/k+-atpase-specific peptide inhibitors/activators of src and src family kinases


A method for regulating src and its downstream signaling pathway which includes binding between src and na+/k+-atpase is disclosed. The na+/k+-atpase/src complex is a functional receptor for cardiotonic steroids such as ouabain.
05/14/15
20150133374

Double-acylated glp-1 derivatives


The invention relates to a derivative of a glp-1 analogue, which analogue comprises a first k residue and a second k residue, at positions corresponding to position 26, and 37, respectively, of glp-1(7-37) (seq id no: 1), and a maximum of eight amino acid changes as compared to glp-1(7-37); which derivative comprises two protracting moieties attached to said first and second k residue, respectively, via a linker, wherein the protracting moiety is selected from chem. 1: hooc—(ch2)x—co—*, and chem.
05/14/15
20150132228

Compositions and methods to evaluate hepatobiliary/gastrointestinal health, enterohepatic circulation, and drug interactions


The present invention relates to the synthesis and use of a novel trifluorinated bile acid analogue, that being, ca-sar-tfma which is useful as an imaging probe, diagnostic agent or contrast agent and is resistant to bacterial deconjugation, wherein the trifluorinated bile acid analogue can be used as a 19f mri tracer exhibiting an increased half-life due to its resistance to choloylglycine hydrolase.. .
05/14/15
20150131649

Content delivery system


The audio outputs 29 of each of a plurality of telecommunications terminals in a packet switched system are synchronised by having each terminal transmit a stream of packets whose rate, and therefore duration is determined according to a clock generator 25, and is thus indicative of the rate at which the terminal is generating its audio output. The signals from each terminal are transmitted to a common server.
05/14/15
20150131412

Timepiece with display devices


A watch including a case in which there is arranged a control system, which includes a time base and is arranged to be able to perform several functions, the watch further including at least two analogue display elements and a digital display controlled independently by the control system, the watch further including a control acting on the control system. The watch is arranged in a first, normal operating mode to provide the user with a time indication by the analogue display elements driven by the control system fitted with the time base, and the watch is arranged in a second, special operating mode to allow the user to select a function via the control, to display on the digital display a value associated with the selected function, and to move an analogue display element opposite the value associated with the selected function..
05/14/15
20150130648

Method and circuit for an analog digital capacity converter


A method for converting a capacitance of a sensing capacitor (10) to be measured into a digital signal is described, wherein according to a clocking in charging processes an integrating capacitor (5), discharged before a start of conversion, of an integrator circuit is charged by an electric current which is obtained from a charging of the sensing capacitor (10) and in discharge processes by brief current surges in the opposite direction which are obtained from a charging of a reference capacitor (6), with the result that on average no charge builds up, and the number of discharge processes occurring during a particular number of clock pulses is counted, wherein the clocking is paused after a predetermined number of cycles, a residual voltage (va1), which the integrator circuit emits due to a residual charge of the integrating capacitor (5), is converted by means of analogue-to-digital voltage conversion (25) into a digital value and the counted number of discharge processes and the particular number of clock pulses are combined with the digital value emitted by the analogue-to-digital voltage converter (25) to form a digital total result, wherein least significant bits of the total result are defined on the basis of the digital value emitted by the analogue-to-digital voltage converter (25) and most significant bits of the total result are defined on the basis of the counted number of discharge processes and the particular number of clock pulses.. .
05/14/15
20150130366

Led driver with external temperature-compensated illumination control signal modulator


The present invention concerns led drivers and is in particular directed to signal overlay for feature addition to an existing led driver. Specifically, the invention is directed to an apparatus (200) for operating a led driver (100), to a method of operating a led driver, to a computer program for operating a led driver and to a led driver unit.
05/07/15
20150126707

Daptomycin analogues and a the preparation of daptomycin or a daptomycin analogue


A method for the synthesis of daptomycin or a daptomycin analogue is carried out on a resin to form a linear precursor followed by a serine ligation macrocyclization in solution. Daptomycin analogues can differ from daptomycin by substitution of amino acids residues and/or deletion or addition of amino acid residues.
The University Of Hong Kong
05/07/15
20150126683

Catalyst compositions and their use for hydrogenation of nitrile rubber


This invention relates to novel catalyst compositions based on ruthenium or osmium carbene-complex catalysts, pref. Of the grubbs-i, -ii or -iii type or fluorenylidene analogues thereof, and terminal olefins, pref.
Lanxess Deutschland Gmbh
05/07/15
20150126439

Pharmaceutical composition


A combination comprising at least a first insulin-like compound and a second insulin-like compound for treating a condition or a disease in a subject in need thereof where administration of insulin would be of benefit to said subject is described. The combination is administered in an amount to achieve a beneficial glycaemic control in said subject as determined by the levels of hba1c in said subject after administration of said combination at the largest meal of the day for said subject; wherein said beneficial glycaemic control by said combination is superior to any glycaemic control achieved by an equivalent dose of iglar in said subject as determined by the levels of hba1c in said subject after administration of iglar for said subject and/or wherein said beneficial glycaemic control by said combination comprises decreasing the levels of hba1c in said subject to about 7 or less after administration of said combination at the largest meal of the day; wherein said first insulin-like compound is longer acting than the second insulin-like compound; wherein said combination is administered at the largest meal of the day for said subject; wherein said first insulin-like compound is at least a long acting insulin, preferably an ultra long acting insulin; wherein said first insulin-like compound is a derivative of a naturally occurring insulin or is an insulin analogue; and wherein said first insulin-like compound has a side chain attached to the a-amino group of the n-terminal amino acid residue of the b chain or to the ε-amino group of a lys residue present in the b chain of the parent insulin, the side chain being of the general formula (i):—w-x-y-z..
Novo Nordisk A/s
05/07/15
20150125431

Glucagon-like-peptide-2 (glp-2) analogues


Glp-2 analogues are disclosed which comprise one of more substitutions as compared to h[gly2]glp-2 and which may have the property of an altered glp-1 activity, and their medical use. The analogues are particularly useful for the prophylaxis, treatment or ameliorating of the gastro-intestinal associated side effects of diabetes..
Zealand Pharma A/s
05/07/15
20150125390

18f-labelled folate/antifolate analogues


The present invention is directed towards new 18f-folate/antifolate analogue radiopharmaceuticals, wherein the phenyl group within folate structures has been replaced by an 18f-heterocycle, their precursors, a method of their preparation, as well as their use in diagnosis of a cell or population of cells expressing a folate-receptor and monitoring of cancer and inflammatory and autoimmune diseases and therapy thereof.. .
Merck & Cie
05/07/15
20150123841

Method for search radar processing using random matrix theory


A new method for processing search radar data is revealed using the mathematics of random matrix theory. During the time that the radar receiver is listening for return target echos, the raw data stream is fed to an analogue to digital converter to create a sample voltage file.
05/07/15
20150121710

Method of analogue measurement scanning on a machine tool


A method of building up a measurement data set for a surface of an object using an analogue measurement probe mounted on a machine tool apparatus which obtains scanned measurement data of the surface over a plurality of offset traverses. Subsequent traverses are offset from previous traverses such that over a series of traverses the analogue probe's surface detecting region progresses i) laterally across the object, and/or ii) away from or towards the object.
Renishaw Plc
04/30/15
20150119463

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.
04/30/15
20150119462

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.
04/30/15
20150119460

14-hydroxy-docosahexaenoic acid compounds


The invention describes novel 14-hydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.
04/30/15
20150119352

Dinuceloside polyphosphates for the treatment of pain


The invention provides a dinucleoside polyphosphate analogue, or a pharmaceutically acceptable salt thereof, for use in the inhibition (or down-regulation) of a pain, via a transducing atp-gated p2x3 receptor, often by means of high-affinity desensitisation (had) mechanism.. .
Globalacornltd.
04/30/15
20150119343

Production of tsg-6 protein


A method of producing a protein or polypeptide, such as, for example, tsg-6 protein, or a biologically active fragment, derivative or analogue thereof, by introducing into mammalian cells a polynucleotide encoding the biologically active protein or polypeptide or biologically active fragment, derivative, or analogue thereof. The cells then are suspended in a protein-free medium that includes at least one agent that suppresses production of hyaluronic acid, hyaluronan, or a salt thereof by the cells.
The Texas A & M University System
04/30/15
20150119259

Nucleic acid sequencing by nanopore detection of tag molecules


This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule..
Genia Technologies, Inc.
04/30/15
20150118674

Anti-hbc quantitative detection method and uses thereof in monitoring and controlling disease progression of chronic hepatitis b patient and in predicting therapeutic effect


The present invention relates to a method for quantitative detection of anti-hbc and its use in monitoring disease progression of chronic hepatitis b patients and predicting therapeutic effects. By quantitative detection of antibodies against hepatitis b core protein (anti-hbc), it is able to monitor disease progression of chronic hepatitis b patients, effectively predict therapeutic effects in chronic hepatitis b patients who accept a therapy against hepatitis b virus (especially, a therapy based on interferon and a therapy based on nucleoside/nucleotide analogue anti-hbv drug), and thus guide the patients to reasonably choose drugs..
Xiamen Innovax Biotech Co., Ltd.
04/30/15
20150118277

Oxysterol analogue oxy133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis


This invention relates, e.g., to a synthetic compound, oxy133, having the structure [formula i] or a bioactive or pharmaceutical composition comprising oxy133 and a pharmaceutically acceptable carrier. Methods are also disclosed for using the compound or bioactive or pharmaceutical composition to treat a variety of disorders, including e.g.
The Regents Of The University Of California
04/30/15
20150118214

Pharmaceutical composition containing human cyclooxygenase and doxorubicin or doxorubicin analogue, preparation method therefor and use thereof in preparing drugs


Provided are a pharmaceutical composition containing human cyclooxygenase and doxorubicin or a doxorubicin analogue using salvia plectranthoides (also referred to as rare grass) as a crude drug, a preparation method therefor and the use thereof in preparing drugs for treating nephritis, cholecystitis and gallbladder polyps, tumours or antiphlogistic and analgesic drugs.. .
04/30/15
20150115158

Photoelectric-type continuous liquid level measurement


A photoelectric-type continuous liquid level measurement method is applied to a photoelectric-type continuous liquid level measurement device which comprises at least one sensor module formed by cascading a plurality of sensors, and comprises: driving the sensors one by one from bottom to top to take a liquid level measurement; after detecting the light intensity of a detection light returned from the position where the sensors are located, the sensors which are currently in a driving state conducting analogue-to-digital conversion on a voltage value corresponding to the detected light intensity to obtain current analogue-to-digital conversion data; according to the correlation between a preset liquid level and the analogue-to-digital conversion data, determining the liquid level of the position where the sensors are located; and summarizing to a transmitter module the liquid level measured by each of the sensors to obtain the total liquid level of a currently measured.. .
Polymer(suzhou) Sensing Technology Co., Ltd.


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Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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