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This page is updated frequently with new Analogue-related patent applications. Subscribe to the Analogue RSS feed to automatically get the update: related Analogue RSS feeds. RSS updates for this page: Analogue RSS RSS


Date/App# patent app List of recent Analogue-related patents
04/23/15
20150112247
 System for gas treatment of a cell implant patent thumbnailnew patent System for gas treatment of a cell implant
System for gas treatment of cellular implants. The system enhances the viability and function of cellular implants, particularly those with high cellular density, for use in human or veterinary medicine.
Giner, Inc.
04/23/15
20150111933
 Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor patent thumbnailnew patent Deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor
The present invention relates to deuterated thiazolidinone analogues as agonists for follicle stimulating hormone receptor and their use for treating fertility disorders.. .
Merck Patent Gmbh
04/23/15
20150111921
 Cortistatin analogues and syntheses therof patent thumbnailnew patent Cortistatin analogues and syntheses therof
The present invention relates to analogs of cortistatin a, j, k, and l, having the general formula: i and salts thereof, wherein r1, r2, r3, r4, n, and m are as defined herein; processes for preparing such compounds and intermediates thereto; pharmaceutical compositions comprising such compounds; methods for treating a proliferative disease; methods for treating a disease associated with aberrant angiogenesis; methods for inhibiting angiogenesis; and processes for preparing cortistatin a, j, k, and l, and analogs thereof.. .
President And Fellows Of Harvard College
04/23/15
20150111914
 Spirolactam cgrp receptor antagonists patent thumbnailnew patent Spirolactam cgrp receptor antagonists
The present invention is directed to spirolactam analogues which are antagonists of cgrp receptors and useful in the treatment or prevention of diseases in which cgrp is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which cgrp is involved..
Merck Sharp & Dohme Corp.
04/23/15
20150111906
 Synthetic rigidin analogues as anticancer agents, salts, solvates and prodrugs thereof, and  producing same patent thumbnailnew patent Synthetic rigidin analogues as anticancer agents, salts, solvates and prodrugs thereof, and producing same
Wherein r, r1 and r2 are selected from hydrogen, aryl, fused aryl, heteroaryl, saturated carbocylclic, partially saturated carbocyclic, saturated heterocyclic, partially saturated heterocyclic, c1-10 alkyl, haloalkyl, alkenyl, alkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, alkenylalkyl, alkynylalkyl, carbocycloalkyl, heterocycloalkyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, nitroalkyl, cyanoalkyl, acetamidoalkyl, and acyloxyalkyl. A process for the preparation thereof is also provided..
04/23/15
20150111826
 Acylated glucagon analogues patent thumbnailnew patent Acylated glucagon analogues
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel acylated glucagon analogue peptides effective in such methods.
Boehringer Ingelheim International Gmbh
04/23/15
20150111823
 Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue patent thumbnailnew patent Method for inhibiting inflammation and pro-inflammatory cytokine/chemokine expression using a ghrelin analogue
The present invention provides a method of ameliorating inflammation, inhibiting proinflammatory cytokine and/or chemokine expression and treating various diseases and/or conditions incidental to the onset of inflammation, in a subject in need of treatment for such conditions, by administering select analogues of native hghrelin.. .
Ipsen Pharma S.a.s.
04/23/15
20150111817
 Glucagon analogues patent thumbnailnew patent Glucagon analogues
The invention provides materials and methods for the treatment of obesity and excess weight, diabetes, and other associated metabolic disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods.
Boehringer Ingelheim International Gmbh
04/23/15
20150111759
 Method of preparation of nanopore and uses thereof patent thumbnailnew patent Method of preparation of nanopore and uses thereof
This disclosure provides systems and methods for sequencing nucleic acids using nucleotide analogues and translocation of tags from incorporated nucleotide analogues through a nanopore. In aspects, this disclosure is related to composition, method, and system for sequencing a nucleic acid using tag molecules and detection of translocation through a nanopore of tags released from incorporation of the molecule..
Government Of The United States Of America, As Represented By The Secretary Of Commerce
04/23/15
20150110818
 Method for presymptomatic diagnosis of coeliac disease and gluten sensitivity patent thumbnailnew patent Method for presymptomatic diagnosis of coeliac disease and gluten sensitivity
The invention relates to the use of an immunologically reactive microbial transglutaminase or its immunologically reactive parts or analogues, which are present in a complex with gliadin or its immunologically reactive parts or analogues, for the diagnosis and/or therapy control of coeliac disease or sprue as well as gluten sensitivity, and a kit for determining the diagnosis and/or therapy control of coeliac disease or sprue as well as of gluten sensitivity, by means of the previously mentioned complex.. .
Aesku.diagnostics Gmbh & Co. Kg
04/23/15
20150109890
new patent

Device for detecting and synchronising the position of a wheel of a timepiece mechanism


A device for detecting and synchronising a position of at least one first wheel of a timepiece mechanism for an electronic analogue wristwatch, includes this first wheel extending in a plane. The detection and synchronisation device includes at least one light source emitting a light beam and at least one light detection system.
The Swatch Group Research And Devlopment Ltd.
04/16/15
20150105695

Method and acquiring and processing acoustic energy emitted by at least one organ in a biological system


In some embodiments, an apparatus for acquiring, processing and transmitting physiological sounds, which may include acoustic sounds from at least one organ in a biological system, may include a sensor for acquiring physiological sounds. analogue signals representative of the physiological sounds are converted into an electrical output.
04/16/15
20150105438

Substituted isoindoline-1,3-dione derivatives


This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast.
Concert Pharmaceuticals, Inc.
04/16/15
20150105363

Methods and formulations for treating scars and beta-catenin-mediated disorders


A topical drug composition for treating a β-catenin-mediated disorder in a mammal is provided comprising a nefopam compound selected from nefopam, or a functionally equivalent analogue, prodrug, salt or solvate thereof.. .
04/16/15
20150105041

Radio repeater system


A system and/or method for facilitating wireless communication in an area where it is difficult to transmit and receive signals may use a preexisting wired emergency communication infrastructure to transmit signals between elements of a radio repeater system. Optionally, the system may include synchronization of retransmissions.
Techmer Ltd.
04/16/15
20150104102

Semantic segmentation method with second-order pooling


Feature extraction, coding and pooling, are important components on many contemporary object recognition paradigms. This method explores pooling techniques that encode the second-order statistics of local descriptors inside a region.
Universidade De Coimbra
04/16/15
20150101204

Method of finding a feature using a machine tool


A method of finding a feature of an object using an analogue probe mounted on a machine tool. The method includes the analogue probe and/or object following a course of motion which causes the analogue probe's surface sensing region to traverse across the feature to be found a plurality of times whilst approaching the feature over successive traverses so as to ultimately arrive in a position sensing relationship with the feature so as to collect scanned measurement data about the feature along at least part of a traverse..
Renishaw Plc
04/09/15
20150099787

Non-flushing niacin analogues, and methods of use thereof


One aspect of the present invention relates to substituted pyridines and pharmaceutially acceptable salts thereof that are active against a range of mammalian maladies. Another aspect of the invention relates to a pharmaceutical composition, comprising a compound of the present invention or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.
Trustees Of Tufts College
04/09/15
20150099191

Co-solvents with high coulombic efficiency in propylene carbonate based electrolytes


A homologous series of cyclic carbonate or propylene carbonate (pc) analogue solvents with increasing length of linear alkyl substitutes were synthesized and used as co-solvents with pc for graphite based lithium ion half cells. A graphite anode reaches a capacity around 310 mah/g in pc and its analogue co-solvents with 99.95% coulombic efficiency.
The Regents Of The University Of California
04/09/15
20150097711

Analogue to digital converter


An analogue to digital converter comprises an input terminal configured to receive an analogue input signal and an output terminal configured to provide an output digital signal. The analogue to digital converter also comprises a main summer having a summing input, a subtracting input and a summing output, wherein the summing input is connected to the input terminal; an analogue filter having a filter input and a filter output, wherein the filter input is connected to the summing output; a quantizer having a quantizer input and a quantizer output, wherein the quantizer input is connected to the filter output; a digital integrator having a digital integrator input and a digital integrator output, wherein the digital integrator output is configured to provide a multi-bit output signal, the digital integrator input is connected to the quantizer output, and the digital integrator output is connected to the output terminal; and a main feedback digital to analogue converter having a main feedback converter input and a main feedback converter output, wherein the main feedback converter input is connected to the digital integrator output, and the main feedback converter output is connected to the subtracting input of the main summer..
Nxp B.v.
04/02/15
20150093419

Absorption enhancers such as e.g. bht, bha or propyl gallate


The invention provides a pharmaceutical composition comprising a mixture of (a) an active macromolecular principle, and (b) an aromatic alcohol absorption enhancer chosen from butylated hydroxy toluene, butylated hydroxy anisole and analogues and derivatives thereof, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active macromolecular principle, and further comprises a pharmaceutical composition comprising a mixture of (a) an active macromolecular principle, (b) an aromatic alcohol absorption enhancer chosen from propyl gallate, butylated hydroxy toluene, butylated hydroxy anisole and analogues and derivatives thereof, wherein the aromatic alcohol absorption enhancer is present in an amount by weight greater than or equal to that of the active macromolecular principle, and (c) a solubilisation aid capable of increasing the solubility of the aromatic alcohol absorption enhancer in aqueous media.. .
Axcess Limited
04/02/15
20150092897

Method and device for achieving cmmb diversity reception


A method and apparatus for achieving china mobile multimedia broadcasting (cmmb) diversity reception are disclosed. The method includes: acquiring respective analogue-to-digital converter (adc) data of two antennas; respectively conducting a synchronization and fast fourier transform (fft) operation on the adc data of the two antennas, acquiring delay information about the two antennas, and according to an operation result, selecting a signal to noise ratio (snr) configuration parameter; according to the delay information, conducting delay compensation on the operated data; and according to the selected snr configuration parameter, merging the data of the two antennas on which the delay compensation is conducted, and outputting the data.
Zte Plaza, Keji Road South
04/02/15
20150092880

Radio communication transmitter apparatus and method


A radio communication transmitter apparatus 20 is operable to transmit multiple radio frequency bands in a telecommunication system. The apparatus comprises a plurality of digital transmitter chains 211 to 21n, wherein each digital transmitter chain is coupled to receive a digital representation 271 to 27n of a respective base band signal for processing by a respective digital transmitter chain.
Telefonaktiebolaget L M Ericsson (publ)
04/02/15
20150092827

Method for determining the imperfections of a transmit pathway and of a receive pathway of an apparatus, and associated radio apparatus


A method is provided for determining the imperfections of a transmit pathway and of a receive pathway of an apparatus, and associated radio apparatus, the transmit pathway comprising a first device for frequency transposition of an analogue sequence to an analogue signal, using a first transposition frequency, the receive pathway comprising a second device for frequency transposition of an analogue signal to an analogue sequence, using a second transposition frequency different from the first transposition frequency.. .
Thales
03/26/15
20150087838

Process for the preparation of radioiodinated 3-fluoropropyl-nor-beta-cit


The invention generally provides processes for the preparation of radioiodinated 3-fluoropropyl-nor-β-cit. In particular, the process uses an arylsilane intermediate, thus avoiding the use of hexamethylditin, and reducing the number of steps previously required for the preparation of radioiodinated 3-fluoropropyl-nor-β-cit from anhydroecgonine methyl ester.
Mallinckrodt Llc
03/26/15
20150087594

Induced neural stem cells


The present invention relates to a method of deriving an induced neural stem cell (incs) by nuclear reprogramming of a somatic cell, wherein the method comprises a step of contacting the somatic cell with oct4 protein or a functionally equivalent analogue, variant or fragment thereof for a limited time period, as well as an induced neural stem cell obtained by this method.. .
Merck Patent Gmbh
03/26/15
20150087588

Combination of somatostatin-analogs with 11beta-hydroxylase inhibitors


The present invention relates to a combination which comprises (a) a somatostatin analogue and (b) a 11beta-hydroxylase inhibitor; each in free form or in the form of a pharmaceutical acceptable salt thereof; the use of such a combination for the preparation of a medicament for the treatment of diseases associated with increased stress hormone levels; a commercial package or product comprising such a combination; and to a method of treatment of a warm-blooded animal, especially a human.. .
Novatis Ag
03/26/15
20150087587

Process for the synchronization of ovulation for timed breeding without heat detection


A method for synchronizing ovulation in sows and gilts by a single injection of hormones is disclosed. A hormone, gonadotropin releasing hormone (gnrh), luteinizing hormone (lh), follicle stimulating hormone (fsh), human chorionic gonadotropin (hcg), analogues, derivatives, agonists or combinations thereof is administered to an open sow post weaning at a specific time to stimulate ovulation of mature responsive follicles.
Thorn Bioscience Llc
03/26/15
20150087033

Methods for making tocoflexols and analogues thereof


Methods for the synthesis of tocoflexols of formula (i) and (ii) and a number of related tocol analogues are provided herein. The methods are economical and amenable to large scale production and can be performed using either pure of partially purified tocotrienols as the starting material..
The United States Of America As Represented By The Department Of Veterans Affairs
03/26/15
20150084799

Multi-level quantizers and analogue-to-digital converters


An analogue-to-digital converter employs one or more reference ladders for generating reference voltages with which to compare the analogue signal for quantization. Selected impedances of the reference ladder can be dynamically decoupled from the input signal in dependence on the value of the output signal in order to reduce headroom in the reference ladders, thus making possible accurate quantization in low-voltage applications..
Cambridge Silicon Radio Limited
03/26/15
20150083589

Bio sensing device


The present invention relates to a bio sensing device having a reaction part and a measuring device which are integrated therein. The bio sensing device includes: a main substrate, a reaction part, a signal processing part, a screen display part, and a housing.
Ceragemmedisys Inc.
03/19/15
20150080461

Composition having antiviral activity against flavivirus


The present invention relates to a composition having antiviral activity for prophylaxis or treatment of flavivirus infection or a disease resulting therefrom in humans or animals, characterised in that the composition comprises quercetin, or analogues, or derivatives thereof. The composition may further comprise a pharmaceutically acceptable carrier.
University Malaya
03/19/15
20150080340

Boronic acid conjugates of oligonucleotide analogues


Oligonucleotide analogues comprising boronic acid and/or boronic ester moieties are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..
Sarepta Therapeutics, Inc.
03/19/15
20150080312

Hexadepsipeptide analogues as anticancer compounds


Or derivatives or pharmaceutically acceptable salts thereof. The invention also includes all isomeric and tautomeric forms of the compound of formula (1) or the derivatives thereof.
03/19/15
20150080305

Application of initial doses of lhrh analogues and maintenance doses of lhrh antagonists for the treatment of hormone-dependent cancers and corresponding pharmaceutical kits


Lhrh analogues and lhrh antagonists for use in the treatment or prophylaxis of hormone-dependent cancers, in particular prostate cancer, prostate carcinoma and/or advanced prostate carcinoma, by administering an initial dose of an lhrh analogue over a first period sufficient to effect hormonal castration, then administering a maintenance dose of an lhrh antagonist over a second period, the dose being insufficient to achieve and/or maintain hormonal castration.. .
Aeterna Zentaris Gmbh
03/19/15
20150080295

Glucagon analogues


The invention provides materials and methods for promoting weight loss or preventing weight gain, and in the treatment of diabetes, metabolic syndrome and associated disorders. In particular, the invention provides novel glucagon analogue peptides effective in such methods.
Zealand Pharma A/s
03/19/15
20150079263

Frozen dessert mixes using soy protein products


A soy protein product having a protein content of at least about 60 wt % (n×6.25) d.b., preferably at least about 90 wt %, and being completely soluble at ph values of less than about 4.4 and heat stable at such ph values is used to provide, at least in part, the protein component of a dairy analogue or plant/dairy blend frozen dessert mix.. .
Burcon Nutrascience (mb) Corp.
03/19/15
20150078496

Mitigating a phase anomaly in an analogue-to-digital converter output signal


A method and apparatus for mitigating a phase anomaly in an analogue-to-digital converter (adc) output signal is disclosed. A plurality of codewords output by the adc are received and information about an estimated level of interference between an output of the adc and an input of the adc due to the codeword is obtained for each codeword based on the logic values of bits in the codeword.
Airbus Defence & Space Limited
03/19/15
20150077631

High-definition digital video signal transmission , camera and acquisition device


Disclosed are a high-definition digital video signal transmission method and device, a high-definition digital video camera and a video acquisition device. The technical solution provided in the embodiments of the present invention comprises: transcoding a high-definition digital video signal in accordance with a line-by-line sequence at a sending end to obtain an analogue video line signal, and sending analogue video line data which is obtained by conversion; and receiving the analogue video line data at a receiving end, and conducting decoding conversion on the received analogue video line data to obtain high-definition digital video line data.
Zhejiang Dahua Technology Co., Ltd
03/12/15
20150073986

Electronic check-based payment issuing, transferring, paying and verifying electronic checks


The invention relates to the sphere of information technologies, in particular, to electronic systems and monetary-fund circulation methods and can be used for solving problems of mutual settlements between participants of the electronic payment system in real-time mode. In doing so, the analogue of monetary funds in the invention presented are electronic bank bearer checks complying with bank regulations and the requirements of applicable legislation.
My Partners And Global Stars Investments (mp&gsi) Ltd
03/12/15
20150073140

Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups


Oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..
Sarepta Therapeutics, Inc.
03/12/15
20150073047

Benzo lipoxin analogues


Benzolipoxin analogs, methods of their preparation and pharmaceutical compositions containing the compounds are provided. The compounds and compositions are useful in methods for treatment of various diseases, including, inflammation, autoimmune disease and abnormal cell proliferation..
University Of Southern California
03/12/15
20150072933

Novel sequences for the control of reproduction in fish


The present invention relates to novel peptide sequences, compositions and methods for controlling fish reproduction. More particularly, the invention provides novel neurokinin b peptides nkf and nkb and analogues thereof that regulate reproduction in fish.
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd.
03/12/15
20150072422

Method of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc)


The present invention relates to methods of enhancing proliferation and/or survival of mesenchymal precursor cells (mpc) and/or progeny derived therefrom in vitro or in vivo comprising exposing the mpc or progeny to sdf-1 or analog thereof. The invention also relates to compositions comprising isolated mpcs or progeny derived therefrom and sdf-1 or analogues thereof.
Angioblast Systems, Inc.
03/12/15
20150071856

Antagonistic peptides for frizzled-1 and frizzled-2


The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled-1 and/or frizzled-2 receptors, which may be useful in molecular imaging of the wound healing process after myocardial infarction and in therapeutic intervention into wound healing after remodeling of the heart, thereby ameliorating the consequences of myocardial infarction.
Academisch Ziekenhuis Maastricht
03/12/15
20150070203

Mixed-signal circuitry


Mixed-signal circuitry, comprising: an array of adc units configured to operate in a time-interleaved manner, and each operable in each of a series of time windows to convert an analogue input value into a corresponding digital output value, each conversion comprising a sequence of sub-conversion operations, each successive sub-conversion operation of a sequence being triggered by completion of the preceding sub-conversion operation; and a controller, wherein: at least one of the adc units is operable to act as a reporting adc unit and indicate, for each of one or more monitored said conversions, whether or not a particular one of the sub-conversion operations completed during the time window concerned; and the controller is operable to consider at least one such indication and to control the circuitry in dependence upon the or each considered indication.. .
Fujitsu Semiconductor Limited
03/12/15
20150070201

Circuitry and methods for use in mixed-signal circuitry


Mixed-signal circuitry, comprising: a first switching-circuitry unit for use in an analogue-to-digital converter; and a second switching-circuitry unit for use in a digital-to-analogue converter, wherein: the first switching-circuitry unit is configured to sample an input analogue signal and output a plurality of samples based on a first plurality of clock signals; the second switching-circuitry unit is configured to generate an output analogue signal based on a plurality of data signals and a second plurality of clock signals; and the first and second pluralities of clock signals have the same specifications as one another.. .
Fujitsu Semiconductor Limited
03/12/15
20150070074

Circuitry and methods for use in mixed-signal circuitry


Switching circuitry for use in a digital-to-analogue converter, the circuitry comprising: a common node; first and second output nodes; and a plurality of switches connected between the common node and the first and second output nodes and operable in each clock cycle of a series of clock cycles, based on input data, to conductively connect the common node to either the first or second output node along a given one of a plurality of paths, wherein the circuitry is arranged such that a data-controlled switch and a clock-controlled switch are provided in series along each said path from the common node to the first or second output node.. .
Fujitsu Semiconductor Limited
03/05/15
20150066196

Method of measurement on a machine tool and corresponding machine tool apparatus


A method of scanning an object using an analogue probe mounted on a machine tool, so as to collect scanned measurement data along a nominal measurement line on the surface of the object, the analogue probe having a preferred measurement range. The method includes controlling the analogue probe and/or object to perform a scanning operation in accordance with a course of relative motion, the course of relative motion being configured such that, based on assumed properties of the surface of the object, the analogue probe will be caused to obtain data within its preferred measuring range, as well as cause the analogue probe to go outside its preferred measuring range, along the nominal measurement line on the surface of the object..
Renishaw Plc
03/05/15
20150065731

Process for microwave assisted synthesis of n-methyl pyrrolidone


The present invention relates to a process for microwave assisted synthesis of n-methyl pyrrolidone (nmp). Particularly the process relates to the synthesis of n-methyl succinimide or corresponding analogues by using microwave irradiation which on hydrogenation in the presence of a hydrogenating catalyst gives n-methyl pyrrolidone.
Council Of Scientific & Industrial Research
03/05/15
20150065395

Compositions and methods for analyzing histidine phosphorylation


A peptide is disclosed of the general structure: z—w—y, wherein z and y are independently a one to eight amino acid sequence wherein the amino acids are selected from glycine and alanine and w is a non-hydrolyzable phis analogue. Such peptides can be used to produce sequence-independent anti-phosphohistidine antibodies.
Sanofi
03/05/15
20150064744

Modified enterokinase light chain


The present invention is related to novel mammalian enterokinase analogues such as mammalian enterokinase light chain analogues and methods of making such. Also described herein is a method for cleaving proteins having an enterokinase cleavage site..
Novo Nordisk A/s
03/05/15
20150064282

Use of neu1 sialidase inhibitors in the treatment of cancer


Use of neul sialidase inhibitors for the treatment of cancer as a monotherapy or in combination with known chemotherapeutics. Preferably, neul sialidase inhibitors are oseltamivir phosphate or 2-deoxy-2,3-dehydro-n-acetylneuraminic acid (dana) or analogues thereof..
02/26/15
20150057224

Methods for chronic pain management and treatment using hcg


A gonadotropin is administered within a surprisingly effective narrow range for the purpose of treating chronic pain or other central sensitization sequelae. In one aspect, a recipient is provided with at least one of human chorionic gonodotropin (uhcg and/or rhcg), a pharmaceutically active hcg analogue, and a pharmaceutically active metabolite of the hcg or analogue at a dosage selected to provide, or be equivalent to, a human subcutaneous dosage of between 120 iu/day and 170 iu/day of hcg, and more preferably between 140 iu/day and 160 iu/day of hcg.
Neuralight Hd, Llc
02/26/15
20150056165

Novel cyclosporin analogues for preventing or treating hepatitis c infection


The present invention relates to novel cyclosporine analogues having antiviral activity against hcv and useful in the treatment of hcv infections. More particularly, the invention relates to novel cyclosporine analogue compounds, compositions containing such compounds and methods for using the same, as well as processes for making such compounds..
Enanta Pharmaceuticals, Inc.
02/26/15
20150054408

Three-phase power supply and system of leds with three-phase power supply


A three-phase power supply (10), intended especially to supply leds system (20), has a system of a diode bridge rectifier which comprises rectifying diodes (101, 102, 103, 104, 105, 106). The three-phase power supply (10) is additionally equipped with fets and each of the rectifying diodes is bypassed by an fet of a rectifying unit (111, 112, 113, 114, 115, 116), respectively, which is controlled by a control system (40), comprising en anglogue-to-digital converter adc 403, a digital-to-analogue converter (402), a microcontroller (401), which provides a control signal to a gate of the appropriate fet through the input/output (404).
Wladyslaw Wlodarczyk Igloo
02/19/15
20150052640

Method for enhancing drought tolerance in plants


A method for increasing drought tolerance in a plant or photosynthetic organism is provided, where the tolerance is increased by applying an effective amount of trimethylamine n-oxide (tmao) or trimethylamine n-oxide di-hydrate, or a tmao chemical derivative, or a tmao chemical analogue and thereof to a plant, seed or photosynthetic organism that has been exposed to or to be exposed to water stress conditions. Water stress tolerant plants or photosynthetic organisms produced through the application of trimethylamine n-oxide (tmao) or trimethylamine n-oxide di-hydrate, or a tmao chemical derivative, or a tmao chemical analogue to a plant or photosynthetic organism are also disclosed..
02/19/15
20150051142

Novel peroral delivery of insulin and its analogues for therapeutic usage


A method for treating type 1 and type 2 diabetes by administering an oral pharmaceutical formulation which comprises of insulin or its analogues amalgamated with suitable encapsulating agents and pharmaceutical excipients. The encapsulated pharmaceutical oral formulation protects insulin or its analogues from harsh milieu of the gastrointestinal tract and facilitates efficient delivery of insulin at targeted sites with sustained hypoglycemic activity..
Transgene Biotek Ltd
02/19/15
20150051137

Peptide and uses therefor


Provided is a method for treatment and/or prophylaxis of a condition associated with t cell mediated chronic inflammatory disease by administration, to a patient, of a peptide comprising n′-svteqgaelsneer-c′ {seq id no: 1) or an analogue thereof that inhibits t cell migration. Also provided is the peptide or its analogue for use in the methods of treatment: and/or prophylaxis of said condition..
The University Of Birmingham
02/19/15
20150049340

Optical coherence tomography with an extended dynamic range


The invention lies in the field of optical metrology and relates to optical coherence tomography (oct). In particular, the invention relates to an apparatus and a method for the depth-dependent adaptation of the dynamic range of an oct system to the profile of the backscattered power to be measured.
Karlsruher Institut FÜr Technologie
02/12/15
20150045451

Polymeric biomaterials derived from monomers comprising hydroxyacids and phenol compounds and their medical uses


The present invention provides new classes of phenolic compounds derived from hydroxyacids and tyrosol or tyrosol analogues, useful as monomers for preparation of biocompatible polymers, and the biocompatible polymers prepared from these monomeric hydroxyacid-phenolic compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations.
Rutgers, The State University Of New Jersey
02/12/15
20150045404

Schweinfurthin analogues


The invention provides a compound of formula (i): wherein r1-r5 have any of the values defined in the specification. The compounds are useful for the treatment of cancer and other diseases..
University Of Iowa Research Foundation
02/12/15
20150045384

Morphan and morphinan analogues, and methods of use


The present application relates to analogues of morphan and morphinan, compositions thereof, and methods for treating a disease or condition comprising administering an effective amount of the compounds or compositions to a subject in need thereof.. .
Alkermes Pharma Ireland Limited
02/12/15
20150045281

Glp-1 prodrugs


The invention relates to a glp-1 prodrug of the general formula i: r1-(nhxaa1)-xaa2-(ohis)-(glp-1 peptide) (formula i), wherein glp-1 peptide is glp-1(8-37) (seq id no: 1) or an analogue thereof having a maximum of nine amino acid changes as compared to glp-1(8-37), r1 is lower alkyl, (nhxaa1) is an amino acid, xaa2 is an amino acid, and (ohis) is a radical of imidazole-lactic acid; or a pharmaceutically acceptable salt, amide, or ester of the prodrug. The invention also relates to specific glp-1 parent drugs of the general formula ii: (hohis)-(glp-1 peptide) (formula ii), as well as specific intermediate products.
Novo Nordisk A/s A Corporation
02/12/15
20150044228

Methods to identify compounds useful for the treatment of proliferative and differentiative disorders


The present invention relates to the discovery, identification and characterization of nucleotide sequences that encode novel substrate-targeting subunits of ubiquitin ligases. The invention encompasses nucleotides encoding novel substrate-targeting subunits of ubiquitin ligases: fbp1, fbp2, fbp3, fbp4, fbp5, fbp6, fbp7, fbp8, fbp9, fbp10, fbp11, fbp12, fbp13, fbp14, fbp15, fbp16, fbp17, fbp18, fbp19, fbp20, fbp21, fbp22, fbp23, fbp24, and fbp25, transgenic mice, knock-out mice, host-cell expression systems and proteins encoded by the nucleotides of the novel substrate-targeting subunits.
New York University
02/12/15
20150042326

Method and device for measuring currents or magnetic fields using hall sensors


The present invention relates to a method and a device for measuring currents or magnetic fields using at least one hall sensor, which is operated with spinning current technology. In addition to first sample values for calculating a spinning current measurement value (6), second sample values are formed from the digitally converted sensor signals (1) of the hall sensor in the method.
Fraunhofer-gesellschaft Zur Foerderung Der Angewandten Forschung E.v.
02/05/15
20150038674

Use of glp-2 analogues in pulmonary diseases for therapeutic purpose


The present invention relates to the use of glp-2 analogue in an efficient amount for the production of a drug specific to treat a pulmonary disease which is caused by oxidative stress, inflammation and/or apoptosis in an organism.. .
02/05/15
20150038571

Antiviral composition against flavivirus


The present invention relates to a composition having antiviral activity for prophylaxis or treatment of flavivirus infection or a disease resulting therefrom in humans or animals, characterised in that said composition consisting of baicalein, or analogues, or derivatives thereof. The composition may further comprise a pharmaceutically acceptable carrier.
University Malaya
02/05/15
20150038463

Compositions and methods to treat cardiac diseases


Phosphonate and phosphinate n-methanocarba derivatives of amp including their prodrug analogs are described. Mrs2339, a 2-chloro-amp derivative containing a (n)-methanocarba(bicyclo[3.1.0]hexane) ring system in place of ribose, activates p2x receptors, ligand-gated ion channels.
The United States Of America, As Represented By The Secretary, Department Of Health And Human Ser
02/05/15
20150038414

Organic compounds


A pharmacutical composition for parenteral administration of a somatostatin analogue salt of aspartate, e.g. Mono- or diaspartate, lactate, succinate, e.g.
Novartis Ag


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Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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