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Analogue patents

      

This page is updated frequently with new Analogue-related patent applications.




 Treatment of abnormal cutaneous scarring patent thumbnailTreatment of abnormal cutaneous scarring
The invention relates to the prevention and treatment of pathologic scars using apc or analogue thereof.. .
Zz Biotech Llc


 Use of apc analogue for wound healing patent thumbnailUse of apc analogue for wound healing
The present application relates to wound repair and wound healing by the application of a therapeutic amount of activated protein c-3k3a (‘apc-3k3a’). Specifically, this application is directed to a method of using apc-3k3a for the treatment of dermal or cutaneous wounds, including but not limited to, acute and chronic wounds, burns and ulcers..
Zz Biotech Llc


 Oligonucleotide analogues incorporating 5-aza-cytosine therein patent thumbnailOligonucleotide analogues incorporating 5-aza-cytosine therein
Oligonucleotide analogues are provided that incorporate 5-aza-cytosine in the oligonucleotide sequence, e.g., in the form of 5-aza-2′-deoxycytidine (decitabine) or 5-aza-cytidine. In particular, oligonucleotide analogues rich in decitabine-deoxyguanosine islets (dpg and gpd) are provided to target the cpg islets in the human genome, especially in the promoter regions of genes susceptible to aberrant hypermethylation.
Astex Pharmaceuticals, Inc.


 External dermatological agent for anti-ageing patent thumbnailExternal dermatological agent for anti-ageing
The present invention aims to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as age-related or senescent wrinkles, fine wrinkles, saggings, spots, etc., as well as maintaining or enhancing the skin barrier functions. The object is solved by providing an external dermal agent for anti-ageing, which contains as an effective ingredient(s) one or more members selected from the group consisting of adenosine n1-oxide 5′-phosphate, analogues thereof, and their salts..
Hayashibara Co., Ltd.


 Controlling time division duplex operation patent thumbnailControlling time division duplex operation
A central node for digital subscriber line access multiplex. The central node supports a plurality of subscriber devices and comprises: a digital interface for upstream communication; a converter device for each one of the subscriber devices wherein each converter device comprises an a/d, analogue to digital, converter and a d/a, digital to analogue, converter; an analogue optical interface for communication of analogue signals for all of the subscriber devices with an intermediate distribution node for digital subscriber line access multiplex; a digital multiplexer/demultiplexer connected between the digital interface and the plurality converter devices; an analogue multiplexer/demultiplexer connected between the analogue optical interface and the plurality of converter devices; and a control signal generator connected to the analogue multiplexer/demultiplexer, wherein the control signal generator is arranged to generate an analogue control signal for controlling time division duplex operation at the intermediate distribution node..
Telefonaktiebolaget Lm Ericsson (publ)


 Codon-optimized gene for mutated shrimp luciferase and  use thereof patent thumbnailCodon-optimized gene for mutated shrimp luciferase and use thereof
There has been a demand for a codon-optimized gene for the mutated catalytic domain of oplophorus luciferase, which is capable of efficiently expressing a protein both in a cultured animal cell and escherichia coli. There has also been a demand for a substrate coelenterazine analogue showing a higher activity than that of native 19 kda protein.
Jnc Corporation


 Cortistatin analogues and syntheses and uses thereof patent thumbnailCortistatin analogues and syntheses and uses thereof
Compounds of formula (a), (b), (c), (d), and (e) are contemplated useful as therapeutics for treating a wide variety of conditions, e.g., including but not limited to, conditions associated with angiogenesis and with cdk8 and/or cdk19 kinase activity. Further provided are methods of inhibiting cdk8 and/or cdk19 kinase activity, methods of modulating the □-catenin pathway, methods of modulating stat1 activity, methods of modulating the tgfβ/bmp pathway, methods of modulating hif-1-alpha activity in a cell, and methods of increasing bim expression to induce apoptosis, using a compound of formula (a), (b), (c), (d), or (e).

 Analogues of 4h-pyrazolo[1,5-a] benzimidazole compound as parp inhibitors patent thumbnailAnalogues of 4h-pyrazolo[1,5-a] benzimidazole compound as parp inhibitors
Disclosed is a series of analogues of 4h-pyrazolo[1,5-α]benzimidazole compound as parp inhibitors. In particular, disclosed in the invention is a compound as shown by formula (i) or a pharmaceutically acceptable salt thereof as a parp inhibitor..
Medshine Discovery Inc.


 Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds patent thumbnailToll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof.
The University Of Kansas


 Data transfer circuit, imaging circuit device, and electronic apparatus patent thumbnailData transfer circuit, imaging circuit device, and electronic apparatus
A data transfer circuit that can suppress a voltage drop in a start signal without narrowing a process margin. The data transfer circuit includes n stages of register sections that are connected in series.
Seiko Epson Corporation


Polarisation-independent coherent optical receiver

In a coherent optical receiver, a received signal and an oscillator-generated signal, having frequency difference such that the receiver operates under intradyne conditions, are made to beat in a 3×3 optical coupler. A polarising beam-splitter splits one of the signals into components with orthogonal polarisation which are applied to inputs of the coupler, which receives the other of the received or oscillator-generated signal.
Scuola Superiore Di Studi Universitari E Di Perfezionamento Sant'anna

Broadband tunable external-cavity laser using small mems mirror

A raman pump laser control apparatus comprises a wavelength division multiplexer, a tap coupler, a photoelectric detector, an analogue amplification processing circuit, an analogue-to-digital converter, a fast raman pump control unit, an digital-analog converter, and a raman pump laser. The fast raman pump control unit, after having known anticipated output light power of the raman pump laser, based on a direct relationship between a current anticipated output light power of the raman pump laser and input digital quantity that is needed by the digital-analog converter, uses a feedforward control mechanism so that actual output light power of the raman pump laser fastly approximates the anticipated output light power thereof, and then synchronously combines with a feedback control mechanism so that the actual output light power of the raman pump laser is precisely locked on the anticipated output light power, thereby achieving fast and precise control of the raman pump laser..
Accelink Technologies Co., Ltd.

Raman pump laser control apparatus and control method therefor

A raman pump laser control apparatus comprises a wavelength division multiplexer, a tap coupler, a photoelectric detector, an analogue amplification processing circuit, an analogue-to-digital converter, a fast raman pump control unit, an digital-analog converter, and a raman pump laser. The fast raman pump control unit, after having known anticipated output light power of the raman pump laser, based on a direct relationship between a current anticipated output light power of the raman pump laser and input digital quantity that is needed by the digital-analog converter, uses a feedforward control mechanism so that actual output light power of the raman pump laser fastly approximates the anticipated output light power thereof, and then synchronously combines with a feedback control mechanism so that the actual output light power of the raman pump laser is precisely locked on the anticipated output light power, thereby achieving fast and precise control of the raman pump laser..
Accelink Electronic Technology Co., Ltd

C1-phostphonate analogue of udp-glcnac for inhibition of o-glcnac transferase

A novel c1-phosphate analogue of uridine-5′-diphosphate (udp)-glcnac as an effective ogt (o-linked n-acetylglucosamine (o-glcnac) transferase) inhibitor, and a preparation method for the same provides a compound having an ogt inhibitory effect that can be used as a useful tool in the studies on various vital phenomena in association with the protein modification by o-glcnac within cells and furthermore as a candidate substance in the treatment or research of diseases related to the protein modification by o-glcnac, such as cancers, diabetes, or degenerative neurological diseases.. .
Soonchunhyang University Industry Academy Cooperation Foundation

Equaliser for the intermediate frequency channel of an fmcw fill level sensor

A fmcw fill level sensor comprising an equaliser that equalizes the intermediate frequency signal digitalised by an analogue-digital converter. Equalising is carried out, for example, in the form of convoluting the digitalised intermediate frequency signal by an equalising function in the time domain.
Vega Grieshaber Kg

Tin-117m somatostatin receptor binding compounds and methods

Tin-117m somatostatin analogues or antagonist are used to treat tumors and symptoms associated with these tumors which express somatostatin receptors, such as gastroenteropancreatic neuroendocrine tumors. The tin-117m somatostatin receptor binding compounds can be administered at a dosage which is effectively apoptotic and not necrotic.
Serene, Llc

Thieno- and pyrrolopyrimidine analogues as anticancer agents and methods of use thereof

The present invention provides for the design and synthesis of halogenated thieno- and pyrrolopyrimidine compounds that exhibit cancer proliferation inhibitory activity and the use thereof for cancer treatment.. .
University Of Maryland, Baltimore County

Recombinant microorganism expressing avermectin analogue and use thereof

The present invention relates to a recombinant microorganism expressing avermectin or analogues thereof and construction method thereof, and also relates to a method of producing avermectin or analogues thereof using the recombinant microorganism, and avermectin or analogues thereof obtained using the method. In addition, the present invention further relates to uses of the avermectin or analogues thereof as insecticides.
Zhejiang Hisun Pharmaceutical Co. Ltd

Quadrature demodulator for a very high bit rate rfid receiver

A quadrature demodulator not requiring analogue mixers. The demodulation is made using a first integrator and a second integrator which are controlled by square logic signals at twice the frequency of the carrier, the received signal being alternatively integrated by the first integrator and the second integrator over periods of time equal to a quarter period of time of the carrier frequency.
Commissariat A L'energie Atomique Et Aux Energies Alternatives

Short interfering rna (sirna) analogues

The present invention is directed to novel double-stranded short interfering (sirna) analogues comprising locked nucleic acid (lna) monomers. Such compounds induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as rna interference (rnai).
Roche Innovation Center Copenhagen A/s

Novel insulin derivatives and the medical uses hereof

The present invention is in the therapeutic fields of drugs for medical conditions relating to diabetes. More specifically the invention relates to novel acylated derivatives of human insulin analogues.
Novo Nordisk A/s

Stable glucagon analogues and use for treatment of hypoglycaemia

The invention relates to derivatives of glucagon analogues comprising the substitutions imp1 and his3, a substituent having three to ten negatively charged moieties covalently attached to a side chain of a lysine as well as intermediates and compositions thereof and their use in medicine.. .
Novo Nordisk A/s

Novel cyp-eicosanoid derivatives

The present invention relates to compounds according to general formula (i) which are analogues of epoxymetabolites produced by cytochrome p450 (cyp) enzymes from omega-3 (n-3) polyunsaturated fatty acids (pufas). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for c the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias..
Board Of Regents, The University Of Texas System

Derivatives of glp-1 like peptides, and uses thereof

The invention relates to derivatives of glp-1 like peptides which are c-terminally extended analogues of native glp-1. The derivatives comprise two side chains, one at a position corresponding to position 42, and one at a position corresponding to position 18, 23, 27, 31, 36, or 38, wherein both positions are when compared to glp-1(7-37).
Novo Nordisk A/s

Cyclic depsipeptide compounds and their uses

The present invention relates to novel cycloundecadepsipeptide compounds and their analogues which bind and inhibit cyclophilins, have reduced immunosuppressive activity and improved physicochemical properties including water solubility. The present invention further relates to pharmaceutical compositions containing said depsipeptide compounds and their analogues for use in the treatment or prevention of diseases and pathologies which may be ameliorated by the inhibition of cyclophilin activity..
Cypralis Limited

Use of fenoterol and fenoterol analogues in the treatment of glioblastomas and astrocytomas

This disclosure concerns the discovery of the use of fenoterol and (r,r)- and (r,s)-fenoterol analogues for the treatment of a tumor expressing a β2-adrenergic receptor, such as a primary brain tumor, including a glioblastoma or astrocytoma expressing a β2-adrenergic receptor. In one example, the method includes administering to a subject a therapeutically effective amount of fenoterol, a specific fenoterol analogue or a combination thereof to reduce one or more symptoms associated with the tumor, thereby treating the tumor in the subject..
Sri International

New substituted biphenyl analogues as dual inhibitors of aromatase and sulfatase

These compounds acting as aromatase and sulfatase inhibitors, they are particularly useful for treating pathological conditions or diseases in which aromatase and sulfatase are involved. Moreover, the present invention provides processes for the preparation of these compounds.

Triarylmethane analogs and their use in treating cancers

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs.
U.s. Government As Represented By The Department Of Veterans Affairs

Use of sodium channel blockers for the treatment of neuropathic pain developing as a consequence of chemotherapy

The present disclosure describes the use of sodium channel blockers such as tetrodotoxin or saxitoxin, its analogues/derivatives as well as their acceptable salts, for treating neuropathic pain resulting from chemotherapy. Methods, compositions, dose units and dose forms of tetrodotoxin related to the use are described..
Wex Medical Limited

An indentation device, instrumented measurement system, and a determining the mechanical properties of materials by the indentation method

The instrumented indentation measurement system includes an indentation device, a loading mechanism, a table for the sample, an analogue-digital converter and a computer. Inside a housing of the device there is arranged a holder for a displacement sensor, rigidly connected to the housing.
Ceske Vysoke Uceni Technicke V Praze, Fakulta Strojni

Fagopyritol synthase genes and uses thereof

The present invention relates to an isolated dna molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described.
Cornell Research Foundation, Inc.

Functionally-modified oligonucleotides and subunits thereof

Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..
Sarepta Therapeutics, Inc.

Fagopyritol synthase genes and uses thereof

The present invention relates to an isolated dna molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described.
Cornell Research Foundation, Inc.

Fagopyritol synthase genes and uses thereof

The present invention relates to an isolated dna molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described.
Cornell Research Foundation, Inc.

Fagopyritol synthase genes and uses thereof

The present invention relates to an isolated dna molecule encoding a fagopyritol synthase. A method for producing a fagopyritol, an insulin mediator, an insulin mediator analogue, an insulin mediator homologue, or an insulin mediator inhibitor is also described.
Cornell Research Foundation, Inc.

Polymeric biomaterials derived from phenolic monomers and their medical uses

The present invention provides new classes of phenol compounds, including those derived from tyrosol and analogues, useful as monomers for preparation of biocompatible polymers, and biocompatible polymers prepared from these monomeric phenol compounds, including novel biodegradable and/or bioresorbable polymers. These biocompatible polymers or polymer compositions with enhanced bioresorbabilty and processibility are useful in a variety of medical applications, such as in medical devices and controlled-release therapeutic formulations.
Rutgers, The State University Of New Jersey

Imidazothiazole derivatives as modulators of tnf activity

A series of substituted imidazo[2,1-b]thiazole derivatives, and analogues thereof, being potent modulators of human tnfα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. .
Ucb Biopharma Sprl

Fused tricyclic imidazole derivatives as modulators of tnf activity

A series of fused tricyclic imidazole derivatives, in particular dihydro-1h-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human tnfα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.. .
Ucb Biopharma Sprl

Biologically active insulin derivatives

A first aspect of the invention relates to a single chain insulin analogue comprising: (a) the a-chain of human or animal insulin, or an analogue or derivative thereof; (b) the b-chain of human or animal insulin, or an analogue or derivative thereof; (c) one or more disulfide bonds between said a-chain and said b-chain; and (d) a further covalent link, l, between a functional group of an amino acid in the a-chain and a functional group of an amino acid in the b-chain, at least one of said functional groups being an amino acid side chain functional group. Further aspects of the invention relate to pharmaceutical compositions comprising said single chain insulin derivatives, and therapeutic uses thereof..
Chemical & Biopharmaceutical Laboratories Of Patras S.a.

Rapid action insulin formulations and pharmaceutical delivery systems

The present invention provides rapid-acting insulin and insulin analogue formulations. The invention further provides delivery devices, particularly infusion sets, which allow for the rapid absorption of insulin and insulin analogues, as well as other active agents.
Thermalin Diabetes, Llc

Compositions

The present invention relates to administration of a dinucleoside polyphosphate analogue or a pharmaceutically acceptable salt thereof, topically in a formulation comprising a suitable excipient or using a device for transdermal delivery, and/or combined with a nanoparticle carrier. The present invention also relates to the therapeutic use of such compositions or devices, in particular in the treatment of pain or epilepsy.
Globalacorn Ltd

Antibiotic compounds that inhibit bacterial protein synthesis

An aminoacylation/translation (ait) system based on the protein synthesis system from the pathogen pseudomonas aeruginosa, was used to screen chemical compounds for identifying inhibitors of protein synthesis. This system includes elongation factors: ef-tu, ef-ts and ef-g, aminoacyl trna synthetase (aars) specific for phenylalanine, phers, and ribosomes isolated from cultures of pseudomonas aeruginosa.
Board Of Regents Of The University Of Texas System

Neurodegenerative disorders

A cyclic polypeptide, derivative or analogue thereof, comprising an amino acid sequence derived from the c-terminus of acetylcholinesterase (ach e), or a truncation thereof.. .
Neuro-bio Ltd

Method for producing induced pluripotent cells

The invention relates to a method for producing induced pluripotent stem cells (ips) by culturing somatic cells subjected to a cellular reprogramming method, characterised in that the somatic cells are cultured in the presence of netrin-1 or an analogue of netrin-1 at least at the beginning of the cellular reprogramming method.. .
Institut National De La Sante Et De La Recherche M Edicale (inserm)

Poly-benzimidazole with pyrene and anthracene flourophore

The present invention discloses polymeric ionic liquid (pil) composition comprising a polymer selected from pbi or abpbi and their derivatives or analogues covalently attached to fluorescence moiety selected from poly aromatic hydrocarbons, preferably pyrene or anthracene. Further, the invention discloses a process for preparing said composition with enhanced fluorescence and stability.
Council Of Scientific & Industrial Research

Glycosylated polypeptide and drug composition containing said polypeptide

[problem] to provide a glycosylated polypeptide having affinity to somatostatin receptors and, compared to somatostatins, having improved in-blood stability. [solution] the glycosylated polypeptide is characterized by at least two amino acids in a somatostatin or an analogue thereof being replaced by glycosylated amino acids..
Glytech, Inc.

Linked purine pterin hppk inhibitors useful as antibacterial agents

The disclosure provides linked purine pterin compounds and analogues thereof that are novel hppk inhibitors. The hppk inhibitors described herein are compounds and the pharmaceutically acceptable salts thereof of general formula i: (i).
The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services

Use of paricalcitol in the treatment of inflammatory anaemia

The present invention discloses the use of paricalcitol, a synthetic vitamin d analogue, in the treatment of inflammatory anaemia, preferably in combination with erythropoeisis-stimulating agents. The use of paricalcitol in the treatment of said pathology is associated with a reduced requirement for erythropoeisis-stimulating agents, with optimised iron absorption and with an increase in plasma erythropoietin levels in said patients.

Modified polymerases for improved incorporation of nucleotide analogues

The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of dna sequencing..
Illumina Cambridge Limited

Cosmetic use of dermicidin, or analogues or fragments thereof, for the prevention and/or treatment and diagnosis of oily skin and aesthetic skin disorders associated therewith

Cosmetic or therapeutic, in particular dermatological, use of dermicidin, or analogues or fragments thereof, for preventing the appearance of imperfections, and also for the treatment and diagnosis of acneic skin or acne-prone skin. The subject matter of the present invention is in particular the use of a cosmetic and/or therapeutic, in particular dermatological, composition containing at least one amino acid sequence of dermicidin, or of an analogue or fragment thereof, or of at least one nucleic acid sequence encoding the sequence, for preventing the appearance of imperfections, and also for the treatment and/or prevention and/or diagnosis of acneic and/or oily or acne-prone and/or oily skin.
L'oreal

Analogue-to-digital converter

This application relates to analogue-to-digital converters (adcs). An adc 200 has a first converter (201) for receiving an analogue input signal (ain) and outputting a time encode signal (dt), such as a pulse-width-modulated (pwm) signal, based on input signal and a first conversion gain setting (gin).
Cirrus Logic International Semiconductor Ltd.

Tetradentate and octahedral metal complexes containing naphthyridinocarbazole and its analogues

Tetradentate and octahedral metal complexes suitable for use as phosphorescent or delayed fluorescent and phosphorescent emitters in display and lighting applications.. .
Arizona Board Of Regents On Behalf Of Arizona State University

Tetradentate metal complexes containing indoloacridine and its analogues

The complexes are suitable for use as phosphorescent or delayed fluorescent and phosphorescent emitters in display and lighting applications.. .



Analogue topics:
  • Carbon Dioxide
  • Amino Acid
  • Radio Signal
  • Inorganic Compounds
  • Hydrogen Production From Water
  • Electrolysis
  • Semiconductor
  • High Energy
  • Semiconductor Material
  • Transmitter
  • Synchronization
  • Concurrent
  • Surfactant
  • Hyperglycemia
  • Pharmaceutically Acceptable Salt


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