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This page is updated frequently with new Analogue-related patent applications. Subscribe to the Analogue RSS feed to automatically get the update: related Analogue RSS feeds. RSS updates for this page: Analogue RSS RSS

Date/App# patent app List of recent Analogue-related patents
 Docosahexaenoyl ethanolamides patent thumbnailnew patent Docosahexaenoyl ethanolamides
The invention describes novel mono or dihydroxy docosahexaenoic acid (dha) analogues, their preparation, isolation, identification, purification and uses thereof.. .
The Brigham And Women's Hospital, Inc.
 Process for preparing synthetic prostacyclins patent thumbnailnew patent Process for preparing synthetic prostacyclins
The presently disclosed subject matter provides methods of preparing synthetic prostacyclin analogues, including beraprost, either as racemic mixtures or as single stereoisomers. Also provided are novel synthetic intermediates for use in these methods..
Lung Biotechnology Inc.
 Rodenticidal norbormide analogues patent thumbnailnew patent Rodenticidal norbormide analogues
The present invention relates to norbormide analogues having rodenticidal activity; rodenticidal compositions comprising the analogues; uses of the analogues as rodenticides; uses of the analogues in the manufacture of rodenticidal compositions; and methods for controlling rodents using the compositions.. .
Landcare Research New Zealand Limited
 Peptides and peptide derivatives based on xenin patent thumbnailnew patent Peptides and peptide derivatives based on xenin
The invention relates to peptides and peptide derivatives based on the naturally occurring peptide xenin. The invention provides a peptide of seq id no.
University Of Ulster
 Modified polymerases for improved incorporation of nucleotide analogues patent thumbnailnew patent Modified polymerases for improved incorporation of nucleotide analogues
The invention relates to modified polymerase enzymes which exhibit improved incorporation of nucleotide analogues bearing substituents at the 3′ position of the sugar moiety that are larger in size than the naturally occurring 3′ hydroxyl group. Also described are methods of using the polymerases to incorporate nucleotides into polynucleotides, particularly in the context of dna sequencing..
Illumina Cambridge Limited
 Recording device patent thumbnailnew patent Recording device
The disclosure relates to a recording device for visualizing measured values and parameters of field devices in automation devices, having at least one analogue input for directly connecting at least one wired field device and having an ethernet interface for communicating with a superordinate device. A graphical display is provided for indications and an exchangeable storage unit is provided for retrospectively recording measured values and parameters of field devices.
Abb Technology Ag
 Device for converting analogue signals into digital signals patent thumbnailnew patent Device for converting analogue signals into digital signals
Method and device for converting analogue signals, of a plurality of pathways, into digital signals. A common circuit (2, 3) generates first analogue signals corresponding to high-order bits of digital signals for each pathway, a first means compares the first analogue signals with the signal to be converted.
Centre National De La Recherche Scientifique (cnrs
 Ghrelin analogues patent thumbnailGhrelin analogues
The present invention relates, inter alia, to ghrelin analogues and their medical use, for example in the treatment of cachexia, chronic obstructive pulmonary disease, gastrointestinal disorders (e.g., gastroparesis and/or inflammatory disorders such as colitis, gut barrier dysfunction, and ischemia reperfusion injury), loss of body weight, and decreased appetite.. .
Zealand Pharma A/s
 Telecommunication system and method that can be used to establish telecommunications with the use of a vehicle using the registration plate code patent thumbnailTelecommunication system and method that can be used to establish telecommunications with the use of a vehicle using the registration plate code
Communication system and method which makes it possible to establish telecommunications with the vehicle user by means of its number plate code, making it possible to establish telecommunications with the vehicle owner by means of their public number and unique identification, thereby linking them to a communication means of their choice (a mobile telephone number, e-mail, web profile or personal analogue communication means), which is hidden from third parties as well as to certain pre-established communication functions (functionality codes), which respond to concrete needs of the users.. .
Person To Vehicle S.l
 Methods and compositions for treating diabetes patent thumbnailMethods and compositions for treating diabetes
Described herein are methods and compositions for treating diabetes mellitus, concerning oral pharmaceutical compositions comprising insulin in combination with a glp-1 analogue.. .
Oramed, Ltd.

Combination product for treating excess weight and/or for improving the figure

A combination product includes as active substances, at least an inhibitor of the hmg-coa-reductase enzyme and citrulline, or a bioequivalent compound thereof, for treating excess weight or obesity and/or the accumulation of body fat. A cosmetic treatment method for improving or slimming the figure and/or for stimulating the loss of excess weight and/or of cellulite and/or for limiting the accumulation thereof, includes the administration of a combination product including as active substances, at least an inhibitor of the hmg-coa-reductase enzyme or a physiologically acceptable salt thereof, and citrulline, or a bioequivalent compound thereof, or one of theirs analogues, and the renewal of the administration until the expected cosmetic effect is obtained.
Institut National De La Recherche Agronomique - Inra

Novel nicotine dna vaccines

The present invention provides dna-nanostructures comprising and at least one targeting moiety, wherein the at least one targeting moiety is linked to the dna-nanostructure; and wherein the at least one targeting moiety is nicotine or a nicotine analogue. These compounds elicit an immunogenic response in individuals and are useful as vaccines for ameliorating nicotine dependence..
Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Ariz

Netrin loop peptide mimetics and uses thereof

In certain embodiments compositions are provided that comprise a pentapeptide comprising the formula: c1-x2-x3-x4-c5 where c1 and c5 are independently selected cysteines or cysteine analogues, or other amino acids with sidechains suitable for cyclization, where the cysteines or cysteine analogs are attached to each other by a linkage that does not comprise x2, x3, and x4; where x2, x3, and x4 are independently selected amino acids; and the peptide, when administered to a cell alters app signaling and/or switches app processing from aberrant to normal. The compositions mitigate amyloid plaque formation..
Buck Institute For Research On Aging

Cu-mediated annulation for the production of 1-amino-2-naphthalenecarboxylic acid derivatives

Invention provides a cheaper and practical protocol for the construction of a wide variety of 1-amino-2-naphthalene-carboxylic acid derivatives and their structural analogues that proceeds with high yields in a single step via intramolecular cascade cyano ene reaction.. .
Council Of Scientific & Industrial Research

Radiolabeled amino acids for diagnostic imaging

This invention relates to novel compounds suitable for labeling by 18f and to the corresponding 18f labeled compounds themselves, 19f-fluorinated analogues thereof and their use as reference standards, methods of preparing such compounds, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (pet).. .
Piramal Imaging Sa

Crystal form of prostaglandin analogue, and preparation method and use thereof

Provided are a crystal form b of a compound having the structure as represented by formula i, and preparation method and use thereof. The x-ray powder diffraction (xrpd) chart of the crystal form b has characteristic peaks at the following diffraction angles: 2.9±0.2°, 6.5±0.2°, 12.6±0.2°, 13.1±0.2° and 20.6±0.2°..
Shanghai Techwell Biopharmaceutical Co., Ltd

Formylated xanthocillin analogues as neuroprotective agents

Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the analogs can be obtained from a microorganism strain of the penicillium chrysogenum species..
Neuron Biopharma, S.a.

Etomidate analogues that do not inhibit adrenocortical steroid synthesis

The invention is directed to compounds according to formula (i): where r1 is l1c(o)ot or l1c(o)ol2c(o)ot; r2 is a substituted or unsubstituted c1-c10 alkyl, c2-c10 alkenyl, or c2-c10 alkynyl, or r1; n is an integer from 0 to 5; each r3 is independently halogen or r2; r4 and r5 are independently h, halogen, cn or cf3; l1 and l2 are each independently a bond, a substituted or unsubstituted c1-c10 alkylene, c2-c10 alkenylene, or c2-c10 alkynylene; and t is h, a substituted or unsubstituted c1-c10 alkyl, c2-c10 alkenyl, or c2-c10 alkynyl, nitrophenol, or cyclopropyl. The invention is also directed to a pharmaceutical composition comprising a compound according to formula (i) and a pharmaceutically acceptable carrier, and to methods for providing anesthesia in mammals by administering such a pharmaceutical composition..
The Brigham And Women's Hospital, Inc.

Therapeutic curcumin derivatives

Curcumin analogues and methods are provided for treatment of disease.. .

Oxyntomodulin analogues and their effects on feeding behaviour

Compounds of the invention are novel peptide analogues of oxyntomodulin (oxm) in which one or more amino acids of the oxm sequence have been changed. Changing amino acids 15-24 of oxm to either amino acids 968-977 of the α-latrotoxin peptide (and variations thereof) or amino acids 15-24 of exendin-4 (and variations thereof), or combinations of sequences from these sources, and/or changing amino acids 27-33 of oxm to amino acids 27-33 of exendin-4, and/or the addition of amino acids to the c-terminus of the peptide, results in a series of analogues of oxm that demonstrate the oxm like activity of reducing food intake, and with certain embodiments a greater ability to decrease food intake..
Imperial Innovations Limited

Derivatives of glp-1 like peptides, and uses thereof

The invention relates to derivatives of glp-1 like peptides which are c-terminally extended analogues of native glp-1. The derivatives comprise two side chains, one at a position corresponding to position 42, and one at a position corresponding to position 18, 23, 27, 31, 36, or 38, wherein both positions are when compared to glp-1(7-37).
Novo Nordisk A/s

Inhibitors of complement activation

The invention relates to factor d inhibitors, which bind to factor d and block the functional activity of factor d in complement activation. The inhibitors include antibody molecules, as well as homologues, analogues and modified or derived forms thereof, including immunoglobulin fragments like fab, f(ab′)2 and fv, small molecules, including peptides, oligonucleotides, peptidomimetics and organic compounds.
Genentech, Inc.

Compounds and methods for the treatment of vascular disease

The present invention relates to a method for the treatment of vascular dysfunction, reducing ischemic pain and/or treatment of a vascular disease comprising administering a therapeutically effective amount of annexin a5 or a functional analogue or variant thereof to a patient in need of such treatment. The vascular dysfunction, ischemic pain and/or vascular disease may be associated with impaired endothelium mediated vasodilatation, a reduced enos activity, and/or a reduced no bioavailability.
Annexin Pharmaceuticals Ab

Bisphenol ether compounds with novel bridging groups and methods for their use

Or a pharmaceutically acceptable salt, tautomer, stereoisomer or deuterated analogue thereof, wherein x, r, r1, r2, r3, r4, m1, m2, l1, l2, j1, j2, a1, a2, b1 and b2 are as defined herein, are provided. Uses of such compounds for treatment of various indications, including prostate cancer as well as methods of treatment involving such compounds are also provided..

Monitoring device, the monitoring of an area of building or land, using at least one light waveguide

A monitoring device is provided that is used for the monitoring of an area of building or land, including an optical strand used as a sensor, one optical source for emitting an optical emission signal transmitted in the optical strand, and one optical analogue detector for detecting an intensity of an optical return signal corresponding to the optical emission signal returning from the optical strand. The monitoring device is arranged as a compact unit and includes a controller for alternately activating and deactivating the emission of the optical source so that a ratio between the non-emission duration and the emission duration is greater than 5000.

Biopotential signal acquisition system and method

A biopotential signal acquisition system, comprising: a first active electrode including an integrated pre-amplifier and an analogue to digital converter; a second active electrode including an integrated pre-amplifier and an analogue to digital converter, wherein the second active electrode has variable gain; a test signal generator for generating a test signal at a test frequency and coupling the test signal to the first and/or second active electrodes; and a digital signal processor configured to: process the digital outputs of the first and second active electrodes to derive a gain control signal based on a difference between the first and second active electrode outputs at the test frequency, and apply the gain control signal to the second active electrode. The disclosure also relates to an electronic circuit or device and a biopotential signal acquisition method..
Stichting Imec Nederland

Crystal form of prostaglandin analogue, and preparation method and use thereof

Provided are a crystal form a of a compound having the structure as represented by formula i, and preparation method and use thereof. The x-ray powder diffraction (xrpd) chart of the crystal form a has characteristic peaks at the following diffraction angles: 2.9±0.2°, 13.6±0.2°, 17.3±0.2° and 18.6±0.2°..
Shanghai Techwell Biopharmaceutical Co., Ltd.

Use of squalamine or analogue as a disinfecting agent

The present invention also provides an aqueous or water-soluble disinfecting composition beneficial for a use according to the invention, characterized in that as disinfecting active compound it comprises a said antibacterial and antifungal compound selected from squalamine and a said squalamine-analogue aminosteroid compound and suitable excipients for a water-soluble or aqueous formulation.. .

Treatment of coagulopathy with hyperfibrinolysis

The present invention relates to the use of thrombomodulin analogues for the manufacture of a medicament for the treatment of coagulopathy with hyperfibrinolysis, such as haemophilia disorders. These thrombomodulin analogues exhibit at therapeutically effective dosages an antifibrinolytic effect.
Paion Deutschland Gmbh

Halogen-stabilized insulin

An insulin analogue comprises a b-chain polypeptide incorporating a halogenated phenylalanine at position b24, b25 or b26. The halogenated phenylalanine may be ortho-monofluoro-phenylalanine, ortho-monobromo-phenylalanine, ortho-monochloro-phenylalanine, or para-monochloro-phenylalanine.
Case Western Reserve University

Preparation method, agricultural composition and applications of natural brassinolide analogs

The present invention provides extraction methods and uses of brassinolide analogues extracted from a plant, including the uses for the promotion of growth, resistance to low temperature and salt tolerance of a plant. Furthermore, the present invention also provides agricultural compositions comprising the brassinolide analogues..
Chengdu Newsun Cropscience Co., Ltd

Sustained release formulations comprising gnrh analogues

The present invention relates to pharmaceutical compositions for the controlled and sustained release of active substance comprising a biodegradable polymer or copolymer. Furthermore, the invention relates to pharmaceutical compositions for the controlled and sustained release of at least one active substance such as peptides or hormones and analogues thereof and the manufacturing process of such pharmaceutical compositions..
Ipsen Pharma S.a.s

Compositions and methods for analyzing histidine phosphorylation

A peptide is disclosed of the general structure: z—w—y, wherein z and y are independently a one to eight amino acid sequence wherein the amino acids are selected from glycine and alanine and w is a non-hydrolyzable phis analogue. Such peptides can be used to produce sequence-independent anti-phosphohistidine antibodies.

Nucleoside 5'-phosphorothioate analogues and uses thereof

Particular nucleoside 5′-phosphorothioate analogues, such as, adenosine or uridine 5′-di- or tri-phosphorothioate analogues in which at least one of the bridging oxygen atoms of the phosphorothioate is replaced by a group such as —ch2— or —ccl2—, and at least one of the non-bridging atoms or negatively-charged atoms of the phosphorothioate is either a sulfur atom or a sulfur ion can be formulated into pharmaceutical compositions. These compounds are useful for treatment of osteoarthritis/calcium pyrophosphate dihydrate (cppd) deposition disease..
The Medical Research, Infrastructure, And Health Services Fund Of The Tel-aviv Medical Center

Chemically cleavable 3'-o-allyl-dntp-allyl-fluorophore fluorescent nucleotide analogues and related methods

This invention provides a nucleotide analogue comprising (i) a base selected from the group consisting of adenine, guanine, cytosine, thymine and uracil, (ii) a deoxyribose, (iii) an allyl moiety bound to the 3′-oxygen of the deoxyribose and (iv) a fluorophore bound to the base via an allyl linker, and methods of nucleic acid sequencing employing the nucleotide analogue.. .
The Trustees Of Columbia University In The City Of New York

Imaging and treatment of neuroendocrine tumors with glucose - dependent insulinotropic polypeptide or analogues or antagonists thereof

The invention relates to a method of imaging pancreatic β-cells, endocrine gastroenteropancreatic tumors and bronchial and thyroid neuroendocrine tumors and a method of treating endocrine gastroenteropancreatic tumors and bronchial and thyroid neuroendocrine tumors by targeting of glucose-independent insulinotropic polypeptide receptors (gip receptors). Compounds considered are gip or a gip analog, each carrying a radionuclide, optionally complexed through a chelator.

Enzymatic transamination of cyclopamine analogs

Provided are processes for the synthesis of amino analogues from ketone starting materials.. .

Organometallic complexes as therapeutic agents

This invention comprises salophene-based metallic complexes. Included are metal-chelating analogues, and method of their preparation and use.
Women & Infants' Hospital

Cyclosporine analogue mixtures and their use as immunomodulating agents

The invention is directed to isomeric mixtures of cyclosporine analogues that are structurally similar to cyclosporine a. The mixtures possess enhanced efficacy and reduced toxicity over the individual isomers and over naturally occurring and other presently known cyclosporines and cyclosporine derivatives.
Aurinia Pharmaceuticals Inc.

Flow imaging

A system suitable for reducing static or slow moving echoes from acoustic boundaries in a system such as pipe walls, blood vessels, tissue structures so that an image from flowing or time varying media such as water, oil, blood etc may be imaged more clearly, the system including an analogue-to-digital converter for digitizing a received analogue signal from a detector, means for digitally separating static or slow moving components of the digital signal, a digital-to-analogue converter to provide an analogue version of the separated static or slow moving components of the signal, and a subtractor to subtract the analogue version of the static or the slow moving components of the signal from an analogue signal received from a detector to produce an analogue signal corresponding to the remaining flow components of the signal.. .
General Electric Company

Continuous-time mash sigma-delta analogue to digital conversion

Continuous-time mash sigma-delta adc with a first modulator with 1.5 bit and a second modulator with 1 bit each receiving also the feedback from the other modulator. Sampling is at higher rate at the second modulator and decimation is performed before summing its output to the output of the first modulator..
St-ericsson Sa

Pharmaceutical compositions for the treatment of inner ear disorders

The present invention provides compositions containing (i) a pharmaceutically active agent selected from a group consisting of an arylcycloalkyamine of a derivative, analogue or pharmaceutically active salt thereof, and (ii) a biocompatible polymer or a combination of biocompatible polymers. The compositions or medicaments containing these compositions may be used for the prevention and/or treatment of inner ear diseases, e.g.

Wireless communication system and method and expansion unit of flat network architecture

Disclosed are a wireless communication system and method and an expansion unit of a flat network architecture. The wireless communication system comprises at least one baseband signal source, an expansion unit (eu) and at least one remote radio unit (ru) connected to the eu.

Amplifier device and activating an amplifier device or the amplifier unit

Known types of amplifiers include so-called class d amplifiers, which first use a pulse-width modulator to convert an analogue signal into a pulse-width modulated switching signal, which is then amplified and subsequently converted back into a continuously variable voltage via a filter. This type of amplifier is particularly energy-efficient and is therefore preferably used for high-power amplifiers.

Dyeing of keratin fibers using indole analogue

The problem is to provide a means for effectively dyeing keratin fibers while retaining high safety. Provided are a dyeing method and a dyeing agent, which include a combination of an oxidation dyeing agent consisting of an indole analogue and a bilirubin oxidase derived from myrothecium verrucaria or bacillus subtilis..

Non-linear parameter measuring method and system strong to noise

A nonlinearity parameter measuring method and system is configured to separately process a signal of a fundamental wave and second harmonic wave that went through a probe attached to a specimen using a circuit including an analogue band pass filter and intermediate frequency amplifier, and minimize the effects caused by noise, thereby measuring an exact nonlinearity parameter.. .

New organocatalytic synthesis of chiral pyrazolidines and their analogues

Disclosed herein is a highly enantio—(75 to 98% ee)and diastereoselective (99 to 100% de)synthesis of functionalised pyrazolidines via tandem a-amination-corey chaykovsky reaction of alpha unsubstituted aldehydes.. .

Terpene analogues and uses thereof for treating neurological conditions

Wherein: y is a c1 to c20 alkylene, c═o, so, so2, or absent; x is h, or1, n—(r2)2, a c1 to c20 alkyl, or a heterocyclyl (for example, heteroaryl), wherein when y is absent x is not h; r1 is h, a c1 to c20 alkyl, or a ch2-aryl; r2 is independently h, a c1 to c20 alkyl, aryl, or1, cn or c(═o)—r3; r3 is a substituted or unsubstituted c1 to c20 alkyl, or a aryl; w is h, c1 to c20 alkyl, or aryl; and z is c1 to c20 alkylene; or a pharmaceutically acceptable isomer, salt or ester thereof. These terpene analogues are useful in treating pain and can also be used to treat other electrical disorders in the central and peripheral nervous system..

Therapeutic compounds

Substituted cinnamoyl anthranilate compounds exhibiting anti-fibrotic activity; or derivatives thereof, analogues thereof, pharmaceutically acceptable salts thereof, and metabolites thereof, with the proviso that the compound is no tranilast.. .

Cables for patient monitoring and related systems with integrated front end

Patient monitoring systems can include a system for transmitting information from a patient parameter sensor to a patient monitor. The system can include an analogue-to-digital converter close to the patient parameter sensor and can transmit digital signals through a cable to the patient monitor..

Synthesis of galanal compounds and analogues thereof

The present disclosure provides methods of preparing glucagon-like peptide-1 (glp-1) receptor modulators, such as compounds of formula (ii) or (vi), or intermediates thereof. The compounds that may be prepared by the described methods are useful for regulating blood glucose levels and/or treating a disease mediated by a glp-1 receptor (e.g., diabetes)..

Substituted bicyclic aza-heterocycles and analogues as sirtuin modulators

Provided herein are novel substituted bicyclic aza-heterocycle sirtuin-modulating compounds and methods of use thereof. The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity.

Method of lowering glycemic index of foods

A method of delaying digestion by an animal or a human of carbohydrates in food, comprising administering an effective amount of one or more flavonoids to the animal or human in conjunction with the food, wherein the flavonoids are selected from luteolin, apigenin, tricin and their pharmaceutically acceptable analogues and derivatives.. .

Functional cell surface display of ligands for the insulin and/or insulin growth factor 1 receptor and applications thereof

Systems for making, identifying, and selecting recombinant cells that express a ligand for the insulin receptor (ir) or insulin growth factor i (igf-1) receptor are described. In general, libraries of recombinant cells are constructed that are capable of displaying a plurality of ligand molecules on the cell surface.

Method of lowering glycemic index of foods

A method of delaying digestion by an animal or a human of carbohydrates in food, comprising administering an effective amount of one or more flavonoids to the animal or human in conjunction with the food, wherein the flavonoids are selected from luteolin, apigenin, tricin and their pharmaceutically acceptable analogues and derivatives.. .

Particulate materials

Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 μm suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v.

Integrated quantum-random noise generator using quantum vacuum states of light

An integrated quantum random noise source includes a substrate, an optical oscillator that may be integral to the substrate coupled by an optical waveguide to an optical directional coupler. The optical directional coupler has two outputs that are coupled by optical waveguides to a pair of photodetectors that are part of a balanced photodetector.

Polypeptide for the protection against heart ischemia-reperfusion injury

A peptide of the formula r1-nh-haegtftsdvssylegqaakefiawlvk-conr2r3 wherein r=h or an organic compound comprising from 1 to 10 carbon atoms and r2 r3=independently h or an alkyl group of 1 to 4 carbon atoms; or certain analogues of said glp-1 peptide can be used for the treatment and prophylaxis of heart ischemia-reperfusion injury. .

Electronic marker locator systems and methods

A locator for determining the depth of a buried electromagnetic marker includes a transmission antenna and two reception antennas. The locator has a major axis and is configured.

Transdermal therapeutic system for administering fentanyl or an analogue thereof

According to the invention a transdermal therapeutic system for administering fentanyl or an analogue thereof through the skin is provided that has a pressure-sensitive adhesive matrix layer containing a mixture of two polyisobutylenes with specific storage moduli.. .

Functionally-modified oligonucleotides and subunits thereof

Functionally-modified oligonucleotide analogues comprising modified intersubunit linkages and/or modified 3′ and/or 5′-end groups are provided. The disclosed compounds are useful for the treatment of diseases where inhibition of protein expression or correction of aberrant mrna splice products produces beneficial therapeutic effects..

Pharmaceutical composition comprising anti-mirna antisense oligonucleotides

The invention provides pharmaceutical compositions comprising short single stranded oligonucleotides, of length of between 8 and 26 nucleobases which are complementary to human micrornas selected from the group consisting of mir19b, mir21, mir122a, mir155 and mir375. The short oligonucleotides are particularly effective at alleviating mirna repression in vivo.

Human insulin analogue and acylated derivative thereof

The present invention provides a human insulin analogue, an acylated derivative thereof and a physiologically acceptable salt. The present invention further provides a preparation method for the insulin analogue and an application of the insulin analogue as a therapeutic agent, and particularly as a diabetes mellitus therapeutic agent..

Anti-infective hydroxy-phenyl-benzoates and methods of use

The invention provides a method for preventing or treating a disease caused by an extracellular microorganism, said method comprising systemically administering to a subject in need thereof a prophylactically or therapeutically effective amount of a salicylic acid (sal) or a sal analogue. The extracellular microorganism can be of the bacterial genus staphylococcus, for example, staphylococcus aureus.

Insulin compositions and making a composition

The invention is related to insulin compositions with a high content of zinc atoms per six molecules of acylated insulin. The insulin is an acylated insulin and may be mixed with a further insulin analogue such as the rapid acting insulin asp b28 human insulin..

Methods and compositions for treating and preventing viral infections

A method of treating or preventing a systemic viral infection in a mammal by administering a pharmaceutically acceptable composition selected from the group consisting of squalamine, an active isomer thereof, and an active analogue thereof, via a dosing regimen that delivers effective antiviral concentrations of squalamine. Also compositions for achieving the systemic antiviral effect..

Mycophenolic acid analogues as anti-tumor chemosensitizing agents

In some embodiments, the present invention provides methods of treating a tumor in a subject. In some embodiments, the methods may include a step of administering to the subject a therapeutic composition that comprises: (a) mycophenolic acid, an analogue thereof, or a derivative thereof; and (b) at least one anti-neoplastic agent.

Uridine and uridine analogues for treatment of specific lung diseases, namely copd and pulmonary fibrosis

The present invention relates to the new indications of chronic obstructive pulmonary disease (copd) and idiophathic lung fibrosis (ipf) for uridine and uridine analogues.. .

Nucleoside analogues for the treatment of a viral infection, and evaluating the sensitivity to said treatment

The present invention describes the use of nucleoside analogues for the treatment of viral infections, in particular of an hiv infection, and also compositions comprising at least one of these analogues, and a method for evaluating the sensitivity to said treatment.. .

Ultra-concentrated rapid-acting insulin analogue formulations

A pharmaceutical formulation comprises insulin having a variant insulin b-chain polypeptide containing an ortho-monofluoro-phenylalanine substitution at position b24 in combination with a substitution of an amino acid containing an acidic side chain at position b10, allowing the insulin to be present at a concentration of between 0.6 mm and 3.0 mm. The formulation may optionally be devoid of zinc.

Popular terms: [SEARCH]

Analogue topics: Carbon Dioxide, Amino Acid, Radio Signal, Inorganic Compounds, Hydrogen Production From Water, Electrolysis, Semiconductor, High Energy, Semiconductor Material, Transmitter, Synchronization, Concurrent, Surfactant, Hyperglycemia, Pharmaceutically Acceptable Salt

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