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Amplification patents

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Methods and compositions for the extraction and amplification of nucleic acid from a sample

Date/App# patent app List of recent Amplification-related patents
 Dynamic gain assignment in analog baseband circuits patent thumbnailDynamic gain assignment in analog baseband circuits
A system and method is provided for filtering and amplifying a signal where amplification can be distributed between stages of a filter and gain can be assigned throughout the filter to optimize system performance. Such a system can be implemented in the baseband section of rf receivers.
 Apparatus for polynucleotide detection and quantitation patent thumbnailApparatus for polynucleotide detection and quantitation
An apparatus for expression profiling analysis, subjecting biological materials to polynucleotide extraction, amplification and analysis. The apparatus include an amplification device which permits the amplification of polynucleotides and an analysis device which quantifies the amount of the amplified polynucleotide products.
 Methods and compositions for the extraction and amplification of nucleic acid from a sample patent thumbnailMethods and compositions for the extraction and amplification of nucleic acid from a sample
Provided herein are methods, compositions and kits to extract and relatively enrich by physical separation or amplification short base pair nucleic acid in the presence of a high background of genomic material (e.g., host or maternal nucleic acids).. .
 Mutational analysis of jak2 patent thumbnailMutational analysis of jak2
An assay for mutations in jak2 is described. The assay uses selective amplification of mutant alleles with a blocker probe which preferentially hybridises to wild type alleles.
 Mosaic tags for labeling templates in large-scale amplifications patent thumbnailMosaic tags for labeling templates in large-scale amplifications
The invention relates to methods of labeling nucleic acids, such as fragments of genomic dna, with unique sequence it referred to herein as “mosaic tag,” prior to amplification and/or sequencing. Such sequence tags are useful for identifying amplification and sequencing errors.
 Methods for true isothermal strand displacement amplification patent thumbnailMethods for true isothermal strand displacement amplification
Methods, primers and probes are provided for the isothermal amplification and detection, without denaturation, of double stranded nucleic acid targets for polymerase strand displacement amplification (“isda”). The methods and compositions disclosed are highly specific for nucleic acid targets with high sensitivity, specificity and speed that allow detection of clinical relevant target levels.
 Integrated audio amplification circuit with multi-functional external terminals patent thumbnailIntegrated audio amplification circuit with multi-functional external terminals
An audio amplification circuit may include an input terminal for receipt of an input signal from a transducer. A signal processor may be coupled to the input terminal for receipt and processing of the input signal to generate a processed digital audio signal in accordance with a programmable configuration setting of the signal processor.
 High resolution rectifier suitable for low voltage signals patent thumbnailHigh resolution rectifier suitable for low voltage signals
A high resolution rectifier suitable for low voltage signals includes a signal input end connected to a signal source for inputting an original ac current; two amplifiers; one receiving the original ac current from a positive end; and the other receiving the ac current from a negative end; amplification factors of the two amplifiers being reversed to each other; two half wave rectifiers each connected to a respective amplifier selected from the two amplifiers; each half wave rectifier receiving an output from the respective amplifier and removing negative half parts of the input current; and an adder connected to the two half wave rectifiers for adding outputs from the two half wave rectifiers so as to full-wave rectifying of the original ac current.. .
 Optical amplifier and method of controlling optical amplifier patent thumbnailOptical amplifier and method of controlling optical amplifier
An optical amplifier comprising: a pumping light source supplying a pumping light to an optical fiber as an amplification medium; an ase light power detector detecting an ase light power including an external ase power flowing from an upstream side outside an amplification signal band; and a control unit setting a gain within the amplification signal band by using the ase light power detected by the ase light power detector outside the amplification signal band. The control unit controls the pumping light source by compensating for an influence of the external ase power, obtained by measuring a relationship between the gain within the amplification signal band and the ase light power outside the amplification signal band, to set initially the gain within the amplification signal band..
 Raman scattering measuring apparatus and raman scattering measuring method patent thumbnailRaman scattering measuring apparatus and raman scattering measuring method
The raman scattering measuring apparatus includes a first light generator to produce a first light, a second light generator to produce a second light having a frequency different from that of the first light, an optical system to focus the first and second lights to a sample, and a detector to detect the first or second light intensity-modulated by raman scattering. The first light generator includes a wavelength extractor that performs a wavelength filtering to extract light of an extraction wavelength from light in a wavelength range including the extraction wavelength and an amplification of the light extracted by the wavelength filtering.
Method for driving image pickup apparatus
A signal for focus detection is generated by a first operation, in which a signal of at least one photoelectric conversion element included in a photoelectric conversion unit is read to an input node of an amplification unit and the signal is supplied to a common output line by the amplification unit and signals for forming an image are generated by a second operation, in which a signal of another photoelectric conversion element included in the same photoelectric conversion unit as that including the at least one photoelectric conversion element from which the signal has been read in the first operation is read to the input node of the amplification unit while holding the signal read in the first operation using the amplification unit and the signals are supplied to the common output line by the amplification unit.. .
Power amplifier spurious cancellation
This disclosure relates generally to power amplification devices and methods of operating the same. The power amplification devices are capable of reducing (and possibly cancelling) modulation of a ripple variation of a supply voltage level of a supply voltage onto a radio frequency (rf) signal.
Capacitive load drive circuit, fluid ejection device and medical device
Operation of a digital power amplifier for power amplification of a modulated signal is stopped in a period in which a voltage value of a drive signal applied to a capacitive load is constant, to thereby suppress power loss. The power amplification is stopped either when half a period of time when the modulated signal in a first voltage state maintains the first voltage state elapses or when half a period of time when the modulated signal in a second voltage state which is lower in voltage than the first voltage state maintains the second voltage state elapses.
Capacitance-to-voltage interface circuits
A capacitance-to-voltage interface circuit is utilized to obtain a voltage corresponding to a detected capacitance differential, which may be associated with the operation of a capacitive sensing cell. The interface circuit includes a capacitive sensing cell, an operational amplifier adapted for selective coupling to the capacitive sensing cell, a feedback capacitor for the operational amplifier, a load capacitor for the operational amplifier, and a switching architecture associated with the capacitive sensing cell, the operational amplifier, the feedback capacitor, and the load capacitor.
Disk brake and production method for a disk brake
A method for manufacturing a disc brake, the disc brake having a brake caliper and a brake actuation mechanism being supported in it, in which the brake actuation mechanism includes an amplification mechanism for introducing a clamping force, an adjustment device for compensation of lining wear with a torque clutch, a thrust element for transmitting the clamping force onto a brake disc and a reset device, which components are arranged around a rod, in which the torque clutch is formed as a roller-ramp-mechanism. A spring force can act onto the torque clutch by means of the reset device thereby forming a torque limit..
Multiplexed analyses of test samples
The present disclosure describes methods, devices, reagents, and kits for the detection of one or more target molecules that may be present in a test sample. The described methods, devices, kits, and reagents facilitate the detection and quantification of a non-nucleic acid target (e.g., a protein target) in a test sample by detecting and quantifying a nucleic acid (i.e., an aptamer).
Ultra sensitive method for in situ detection of nucleic acids
Disclosed is a method for in situ detection of one or more target nucleic acids based on a combination of rnascope® method and a general ish signal amplification method. This new method produces high signal intensity and while keeps low background noise of signal amplification.
Apparatus and method for electrical detection of oligonucleotides through pore blockades
Systems and methods for specific nucleic acid (na) sequence detection that do not rely on polymerase chain reaction (pcr) for target sequence amplification and do not require any special reagents other than a complementary sequence capture probe conjugated to spherical beads.. .
Liquid reflux high-speed gene amplification device
A switching valve disposed on the tubular flow channel, and configured to control the flow of the circulating liquid.. .
System and method for determining copies-per-unit-volume using pcr and flow control of droplets
Methods and systems for quantification of a target nucleic acid in a sample are provided. The method includes forming a plurality of discrete sample portions.
Microfluidic devices and methods for cell sorting, cell culture and cells based diagnostics and therapeutics
Microfluidic devices and methods that use cells such as cancer cells, stem cells, blood cells for preprocessing, sorting for various biodiagnostics or therapeutical applications are described. Microfluidics electrical sensing such as measurement of field potential or current and phenomena such as immiscible fluidics, inertial fluidics are used as the basis for cell and molecular processing (e.g., characterizing, sorting, isolation, processing, amplification) of different particles, chemical compositions or biospecies (e.g., different cells, cells containing different substances, different particles, different biochemical compositions, proteins, enzymes etc.).
Method for detecting the presence of a nucleic acid in a sample
An automated method for detecting the presence of a nucleic acid in a sample, where the method is performed within a housing of a self-contained, stand-alone analyzer. The method includes purifying the nucleic acid after it has been immobilized on a magnetically-responsive solid support.
Automatic detection kit for detecting hla alleles using real-time polymerase chain reaction
Provided is an automatic detection kit for automatically detecting hla alleles using a real-time polymerase chain reaction (pcr). The real-time pcr is performed on dna isolated from a sample using a primer which is able to specifically bind to hla alleles and a fluorescent probe which is able to detect amplification of the hla alleles in real time, and the hla allele typing is performed by analyzing a fluorescence value obtained from the real-time pcr using an hla automatic typing..
Gene detection assay for improving the likelihood of an effective response to an egfr antagonist cancer therapy
The invention provides a method for more effective treatment of patients susceptible to or diagnosed with tumors overexpressing egfr, as determined by a gene amplification assay, with an egfr antagonist. Such method comprises administering a cancer-treating dose of the egfr antagonist, preferably in addition to chemotherapeutic agents, to a subject in whose tumor cells erbb1 gene has been found to be amplified e.g., by fluorescent in situ hybridization.
Switching regulator and electronic device
There is provided a switching regulator including an overcurrent protection circuit which is able to automatically return from an overcurrent state. The switching regulator includes an error amplification circuit which amplifies a difference between a feedback voltage and a reference voltage based on an output voltage and outputs the amplified difference; a pwm comparator which compares an output of the error amplification circuit with an output of a triangular wave oscillation circuit, and controls an output transistor; an overcurrent detection circuit which monitors a load current flowing through a load connected to an output terminal, detects that the load current is an overcurrent, and outputs an overcurrent detection signal causing a switching operation to stop; and a negative feedback control circuit which receives the overcurrent detection signal, and controls the load current to a predetermined current value..
Multi-level sigma-delta adc with reduced quantization levels
A multi-level sigma-delta analog to digital converter provides multi-level outputs using a quantizer with reduced quantization levels. The converter comprises a direct path comprising a computation block, an analog integrator and the quantizer with reduced quantization levels.
Method and device for discharging an inverter capacitor
The invention relates to a control device for triggering a semi-conductor switch of an inverter, the control device comprising: a switching signal amplification device, which is designed to amplify a switching signal generated by a control regulation of the inverter, and to generate a first switching control signal that triggers the semi-conductor switch in a switching mode; a current regulation device, which is coupled to a current sensor output of the semiconductor switch and is designed to generate a second switching control signal that triggers the semi-conductor switch in a linear mode; and a selection device, which is coupled to the switching signal amplification device and the current regulation device and is designed to output, on the basis of at least one mode selection signal, either the first switching control signal or the second switching control signal in order to trigger a control terminal of the semi-conductor switch.. .
Transducer, and manufacturing method of the transducer
A transducer, and a method for manufacturing the transducer are provided. The transducer includes a substrate-side electrode provided in one side of an insulative substrate and an opposite plate including an opposite electrode disposed opposite to the substrate-side electrode, and which performs a function such as a reduction in impedance, conversion of capacitance, signal amplification, thereby achieving size reduction of the transducer itself.
Radiation detector
The present invention provides a radiation detection system for detecting x-ray and gamma rays featuring cd1-xmgx te in solid solution as a crystal semiconductor and electrical connection means. The crystal has a composition in the range of cd0.99mg0.01te to cd0.71mg0.29te and may be doped with indium or another group iii element, which may be suitable for use at room temperature as well as controlled temperatures.
Polymeric carriers for immunohistochemistry and in situ hybridization
Certain disclosed embodiments of the present invention concern the synthesis, derivatization, conjugation to immunoglobulins and signal amplification based on discrete, relatively short polymers having plural reactive functional groups that react with plural molecules of interest. Reactive functional groups, such as hydrazides, may be derivatized with a variety of detectable labels, particularly haptens.
Method for detecting protein that interacts with target substance
The present invention provides a method for detecting an interaction, which method can solve not only the problem of false negatives but also the problem of false positives. This method is a method for detecting a protein(s) that interact(s) with a target substance(s), the method comprising repeating a (1) transcription step, (2) assignment step, (3) selection step, and (4) amplification step, wherein: (a) in each of a plurality of times of preparation of a cdna library among the initial preparation of a cdna library and the round(s) of preparation of a cdna library in the later amplification step(s), the cdna library is prepared using a primer(s) having a sequence(s) specific to the time of preparation; (b) the cdna libraries prepared using the primers having sequences specific to the times of preparation are mixed, and sequences in the cdna library mixture are determined; (c) the determined sequences are subjected to measurement of the number(s) of molecules encoding the same candidate protein(s) for each time of preparation based on the sequence(s) specific to the time of preparation; and (d) a candidate protein(s) encoded by a molecule(s) that significantly increase(s) as the preparation rounds proceed is/are detected as the protein(s) that interact(s) with the target substance(s)..
Allele-specific amplification
The present invention includes a method of allele-specific amplification, utilizing an allele-specific oligonucleotide, at least partially complementary to more than one variant of the target sequence, but having a 3′-terminal nucleotide complementary to only one variant of the target sequence and having at least one nucleotide with a base covalently modified at the exocyclic amino group, wherein the allele-specific oligonucleotide is extended by a nucleotide-incorporating biocatalyst predominantly when hybridized to the variant of the target sequence for which it has said complementary 3′-terminal nucleotide.. .
Chimeric primers with hairpin conformations and methods of using same
Methods and compositions for nucleic acid amplification, detection, and genotyping techniques are disclosed. In one embodiment, a nucleic acid molecule having a target-specific primer sequence; an anti-tag sequence 5′ of the target-specific primer sequence; a tag sequence 5′ of the anti-tag sequence; and a blocker between the anti-tag sequence and the tag sequence is disclosed.
Compositions and methods for genetic analysis of embryos
The present disclosure provides for compositions and methods for genetic analysis of embryos. Generally, the compositions and methods provide for the acquisition of an sample containing rna from an embryo, genetic analysis involving various techniques such as sequencing-, hybridization- or amplification-based methods, and the detection of genetic alterations that may affect the health and quality of the embryo.
Chromatography method, chromatography kit, and method of producing an insoluble carrier for chromatography
A chromatography method including a step of developing a complex of a specimen and a labeled substance modified by a first bondable substance which can be bonded to the specimen on an insoluble carrier, a step of capturing the complex of the specimen and the labeled substance at a reactive site on the insoluble carrier, a step of washing the reactive site on the insoluble carrier using a washing liquid, a step of detecting the specimen which is captured at the reactive site after a signal of the labeled substance is amplified by an amplification liquid, in which the reactive site on the insoluble carrier includes (i) a second bondable substance which can be bonded to the specimen or a substance having affinity to the first bondable substance which can be bonded to the specimen, and (ii) polyethylene glycol having the molecular weight from 1,500 to 10,000.. .
Short-pulsed compact mopa
A master oscillator power amplifier (mopa) system includes an oscillator having a neodymium-doped gadolinium vanadate gain-medium and delivering seed-pulses. A length of single mode fiber is used to broaden the spectrum of the seed pulse.
System for cooling devices
A cooling system is provided. The cooling system includes an enclosure.
Multi-core amplification optical fiber and multi-core optical fiber amplifier
A multi-core amplification optical fiber includes a plurality of rare-earth-doped core portions and a cladding portion positioned at an outer periphery of the core portions and having refractive index lower than those of the core portions. When a doping concentration of the rare-earth of each of the core portions is 250 ppm to 2000 ppm, a relative refractive index difference of each of the core portions relative to the cladding portion is 0.5% to 2% at a wavelength of 1550 nm, and a core diameter of each of the core portions is 1 μm to 5 μm, a separation distance between each of the core portions and adjacent one of the core portions is set at equal to or larger than 30 μm and at equal to or smaller than 60 μm so that a light-crosstalk between the adjacent core portions is equal to or lower than −30 db..
Optical amplification component and fiber laser device
An optical amplification component 1 includes a heat dissipation plate 10 and an amplification optical fiber 20 arranged on the heat dissipation plate 10. A first fiber portion 20a extending from a reference position rp between a first end e1 and a second end e2 of the amplification optical fiber 20 toward the first end e1 and a second fiber portion 20b extending from the reference position rp toward the second end e2 are wound in a spiral around the reference position rp so as to be along each other as well as not to overlap with each other, and the distance between the first fiber portion 20a and the second fiber portion 20b increases toward the ends thereof..
Mixed reality augmentation
Embodiments that relate to providing motion amplification to a virtual environment are disclosed. For example, in one disclosed embodiment a mixed reality augmentation program receives from a head-mounted display device motion data that corresponds to motion of a user in a physical environment.
System and method for the detection and control of illicit trafficking of special nuclear materials
It is a system and method for the monitoring of the illicit traffic of fissile materials that can be used for the construction of nuclear bombs or not fissile that can be used for the construction of radiological dispersion devices; characterized by reducing the rate of spurious detection and increase the probability of detection compared with equivalent devices of the prior art. Some of its embodiments include the use of a radiation detector/telemeter ensemble with manual or automatic pointing and an ensemble of radiation detector/camera with an automatic object tracker along with data acquisition and processing electronics; which allow the calculation of the correlation between the characteristic profile produced by the mo and a predicted reference profile.
Alarm detector
An alarm sounder and at least one sound amplification component having at least one horn shaped channel form an alarm detector. The at least one horn shaped channel has a throat end and an outlet end, the throat end being disposed corresponding to a sound-making end of the alarm sounder.
Operational amplifier circuit
Provided is an operational amplifier circuit capable of operating with lower current consumption. An amplifier stage, a fir filter, and a sample and hold circuit are connected in series, thus enabling reduction of an input offset voltage and amplification of an input signal voltage without using an integral circuit.
Xeno transduction system
An oscillation frequency power amplification circuit is disclosed herein having improved power and frequency receiver characteristics. The power circuit is characterized by having atmospheric capacitance of device electronic amplify resonate by antenna vessel.
Methods and systems for visualizing and evaluating data
A computer-implemented method of generating a digital polymerase chain reaction (dpcr) result is provided. The method includes detecting a first set of emission data from a plurality of samples, each included in a sample region of a plurality of sample regions, at a first time during an amplification period.
Sequence amplification with loopable primers
The present disclosure relates to the amplification of target nucleic acid sequences. This can be accomplished via the use of various primers.
Methods and devices for amplification of nucleic acid
The present invention relates to methods and devices for amplifying nucleic acid, and, in particular, amplifying so as to generate products on a surface without the use of emulsions. In a preferred embodiment, a plurality of groups of amplified product are generated on the surface, each group positioned in different (typically predetermined) locations on said surface so as to create an array..
Multiplex nucleic acid detection methods
Methods for multiplex ligation-dependent probe amplification include (a) providing a sample tissue to query different target nucleic acids, (b) providing different probe sets for each of the target nucleic acids, each probe set including a first locus specific probe having a first adapter sequence and a first target specific portion and a second locus specific probe having a second adapter sequence, and a second target specific portion adjacent to the first target specific portion, (c) hybridizing the probe sets to the target sequences to form hybridization complexes, (d) ligating the hybridization complexes to form ligated probes, (e) amplifying the ligated probes to form amplicons, the amplifying step being carried out with a first universal primer including a region complementary to the first adapter sequence and a second universal primer including a region complementary to the second adapter sequence, and (f) detecting the amplicons in a detection system by sequencing each of the amplicons.. .
Detection and quantification of biomolecules using mass spectrometry
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
Quantitative nuclease protection assay (qnpa) and sequencing (qnps) improvements
The present disclosure provides an improvement to quantitative nuclease protection assay (qnpa) and quantitative nuclease protection sequencing (qnps) methods. The disclosed methods use nuclease protection probes (npps) that include 5′-end and/or 3-end flanking sequences, which provide a universal hybridization and/or amplification sequence.
Methods for nucleic acid manipulation
A method for replicating and amplifying a target nucleic acid sequence is described. A method of the invention involves the formation of a recombination intermediate without the prior denaturing of a nucleic acid duplex through the use of a recombination factor.
Dna fragment detection method, dna fragment detection kit and the use thereof
The disclosure claims a cleaved deoxyribonucleic acid (dna) detection method, a dna fragment detection kit and use thereof. Wherein, the method includes the steps of: designing primers according to a test site or a test region of the dna fragment; cyclizing the dna fragment to obtain acyclized dna; implementing polymerase chain reaction (pcr) amplification for the cyclized dna by using the primers; and detecting the pcr amplification product.
Recombinase polymerase amplification
This disclosure describes related novel methods for recombinase-polymerase amplification (rpa) of a target dna that exploit the properties of recombinase and related proteins, to invade double-stranded dna with single stranded homologous dna permitting sequence specific priming of dna polymerase reactions. The disclosed methods have the advantage of not requiring thermocycling or thermophilic enzymes.
Organism identification panel
Methods and containers are provided for identifying a species, illustratively a bacterial species. Illustrative methods comprise amplifying various genes in the nucleic acid from the bacterial species in a single reaction mixture using pairs of outer first-stage primers designed to hybridize to generally conserved regions of the respective genes to generate a plurality of first-stage amplicons, dividing the reaction mixture into a plurality of second-stage reactions, each using a unique pair of second-stage primers, each pair of second-stage primers specific for a target bacterial species or subset of bacterial species, detecting which of the second-stage reactions amplified, and identifying the bacterial species based on second-stage amplification.
Method for quantifying human dna
The invention provides for a method for quantifying one or more nucleic acids of a genome in a sample comprising the steps of (a) amplifying a first nucleic acid to be quantified, (b) determining the amount of said first nucleic acid by comparison of the amount of amplification product from said first nucleic acid with at least one amplification product from a second template nucleic acid, (c) wherein said second template nucleic acid was generated using whole genome amplification and wherein the starting concentration of the second template nucleic acid is known.. .
Direct amplification and detection of viral and bacterial pathogens
Provided are methods for identifying the presence or absence of a target nucleic acid from a microorganism using direct amplification without a step of extraction of the nucleic acids, but retaining substantially the same specificity and sensitivity of methods assaying extracted nucleic acids. Further provided are reagent mixtures that allow for direct amplification of a sample, without the step of nucleic acid extraction..
Radiographic imaging control device, radiographic imaging system, radiographic imaging device control method, and recording medium
A radiographic imaging control device is provided with a radiation detector, amplifiers and a controller. A plurality of pixels are arrayed in the radiation detector, each pixel including a sensor portion that generates charges in accordance with irradiated radiation and a switching element that is for reading out the charges generated at the sensor portion.
Method and equipment for controlling radio-frequency signal
The present invention describes a rf signal control method and device that adjusts the first down-converter gain attenuation and uses the adjusted first down-converter gain attenuation to change the rf signal. The rf signal control method and device also uses a determined linear filter parameter to perform linearity improvement on the digital signal after the rf signal goes through a down-converter and analog-to-digital converter.
Control method and equipment for radio-frequency signal
The present invention describes a rf signal control method and device that changes the gain attenuation in real time and uses the changed gain attenuation to adjust the rf input signal. The rf signal control method and device also uses determined linear filter parameters for linearity improvement on the digital signal that results from a down-conversion and analog-to-digital converter on the rf input signal.
Circuit arrangement for compensating an attenuation occurring in an antenna signal connection between a mobile terminal and an antenna and compensation method for this purpose
A circuit arrangement (1) is described for compensating an attenuation (ko, ka, ka1, ka2) occurring in an antenna signal connection (2) between a mobile terminal (3) and an antenna (4) with at least one antenna signal amplifier (5a, 5b) in the antenna signal connection (2) and with a control unit (8) for setting an amplification factor (v) by which the antenna signal routed through an allocated antenna signal amplifier (5a, 5b) is amplified or attenuated. The circuit arrangement (1) has a detection unit (7) for detecting an antenna signal power (p) of the antenna signal in the signal path of the antenna signal connection (2).
Method and apparatus for random access channel probe initialization using transmit diversity
Embodiments of the present invention may separately utilize transmit paths of a mobile transmit diversity device to initialize communication with a base station over a random access channel, particularly where the transmit paths have power amplifiers with different characteristics, e.g., different power amplification.. .
Defect inspecting apparatus and defect inspecting method
An invention being applied is a defect detecting apparatus that has: an illuminating optical system with a laser light source for irradiating a sample on whose surface a pattern is formed with light; a detecting optical system with a sensor for detecting light generated from the sample illuminated by the illuminating optical system; and a signal processing unit that extracts a defect from an image based on the light detected by the detecting optical system, in which an amplification rate of the sensor is dynamically changed during a time when the light is detected by the detecting optical system.. .

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Amplification topics: Amplification, Nucleic Acid, Nucleotide, High Resolution, Modulation, Feedback Signal, Nanoparticle, Semiconductor, Raman Amplifier, Resonance Frequency, User Interface, Transmitter, Methylation, Sample Preparation, Sequencing

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