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This page is updated frequently with new Amplification-related patent applications. Subscribe to the Amplification RSS feed to automatically get the update: related Amplification RSS feeds. RSS updates for this page: Amplification RSS RSS


Date/App# patent app List of recent Amplification-related patents
01/29/15
20150031575
 Uses of ided nanostructures in nucleic acid technology patent thumbnailnew patent Uses of ided nanostructures in nucleic acid technology
The present invention relates to compositions comprising a porous nanostructure of a known characteristics and a fragment of nucleic acid having a known sequence. Methods of use of the compositions were also provided, for example in dna amplification, detection, and dna sequencing..
Nvigen, Inc.
01/29/15
20150031559
 Increased confidence of allele calls with molecular counting patent thumbnailnew patent Increased confidence of allele calls with molecular counting
Aspects of the present invention include methods and compositions for determining the number of individual polynucleotide molecules originating from the same genomic region of the same original sample that have been sequenced in a particular sequence analysis configuration or process. In these aspects of the invention, a degenerate base region (dbr) is attached to the starting polynucleotide molecules that are subsequently sequenced (e.g., after certain process steps are performed, e.g., amplification and/or enrichment).
Population Genetics Technologies Ltd
01/29/15
20150031557
 Detection of shiga toxin genes in bacteria patent thumbnailnew patent Detection of shiga toxin genes in bacteria
The disclosed invention is related to methods, compositions and kits for targeting nucleic acid derived from shiga toxin-producing bacteria such as e. Coli.
Gen-probe Prodesse, Inc.
01/29/15
20150031555
 Method for correction of bias in multiplexed amplification patent thumbnailnew patent Method for correction of bias in multiplexed amplification
This invention relates a method to correct for bias inherent to multiplexed sequence amplification. The resulting corrected data is a much more accurate representation of true quantities than unprocessed data..
Gigagen, Inc.
01/29/15
20150031320
 Adaptive harmonic rejection receiving device and method patent thumbnailnew patent Adaptive harmonic rejection receiving device and method
The invention provides an adaptive harmonic rejection (hr) receiving device, including a low noise amplification module; at least one hr mixer; at least one non-harmonic rejection (nhr) frequency mixer; and a control device. A received signal passes through the low noise amplification, and then passes through the at least one hr mixer or the at least one nhr mixer; the control device measures a receiving signal strength index (rssi) after the received signal passes through the at least one hr mixer or the nhr mixer, and selects an nhr mixer or an appropriate hr mixer for the received signal according to a result of the measurement.
Montage Technology (shanghai) Co., Ltd.
01/29/15
20150031318
 Transmitter and method with rf power amplifier having predistorted bias patent thumbnailnew patent Transmitter and method with rf power amplifier having predistorted bias
A transmitter (32) generates a time-varying stabilized bias signal (82) from which sub-rf distortion signals (26, 29) have been cancelled. The distortion signals (26, 29) are byproducts of imperfect amplification and of biasing networks.
Crestcom, Inc.
01/29/15
20150031107
 Pcr reaction mixtures with decreased non-specific activity patent thumbnailnew patent Pcr reaction mixtures with decreased non-specific activity
The present invention provides methods for improving the specificity of nucleic acid amplification comprising incubating a nucleic acid molecule with a polymerase-sso7 dna binding domain conjugate and arginine, spermidine, or spermine. The present invention also provides reaction mixtures and kits for improving the specificity of nucleic acid amplification..
Bio-rad Laboratories, Inc.
01/29/15
20150031087
 Nucleic acid amplification method patent thumbnailnew patent Nucleic acid amplification method
The invention provides an ultra-rapid nucleic acid amplification method performed in a flow channel. Specifically, the invention provides a nucleic acid amplification method for performing a pcr reaction by supplying a pcr sample solution to a nucleic acid amplification device comprising a serpentine channel adapted to perform at least one pcr cycle, the nucleic acid amplification device comprising a dna denaturation temperature zone corresponding to the curved portions at one side, an annealing temperature zone corresponding to the curved portions at the other side, and an extension temperature zone positioned between the annealing and dna denaturation temperature zones, wherein the pcr sample solution is introduced in the form of sample plugs separated by gas into the serpentine channel using a pump, the sample solution being supplied into the channel in a state such that the solution is separated by gas into a segment corresponding to one pcr cycle or smaller segments..
National Institute Of Advanced Industrial Science And Technology
01/29/15
20150031086
 Ligase-assisted nucleic acid circularization and amplification patent thumbnailnew patent Ligase-assisted nucleic acid circularization and amplification
Provided herein are methods for generation and amplification of a single-stranded dna circle in a single reaction vessel from a linear dna without any intervening purification steps. The single-stranded dna circle is generated via a template-independent single-stranded dna ligation.
General Electric Company
01/29/15
20150031039
 Methods and device to balance radiation transference patent thumbnailnew patent Methods and device to balance radiation transference
A method and device for adjusting the temperature of a sample by heating a substrate with a laser diode light; said light projected on to the substrate to absorb the light and convert the light energy to a heat energy thereby raising the temperature of the substrate corresponding to the intensity of the light energy, the substrate configured to transfer the thermal energy substantially homogenously to the sample. The device or method suitable for amplification of a nucleic acid sample..
Agency For Science, Technology And Research
01/29/15
20150031038
new patent

Sample preparation methods


The present invention provides whole blood nucleic acid extraction methods, compositions, and kits, as well as nested isothermal amplification methods, compositions, and kits. In certain embodiments, these methods are applied to detecting lyme disease, including in patients without classic erythema migrans skin lesions..
Ibis Biosciences, Inc.
01/29/15
20150031036
new patent

Nucleic acid amplification reaction apparatus and nucleic acid amplifying method


A nucleic acid amplification reaction apparatus includes (a) a rotating body mounted with a nucleic acid amplification reaction container including reaction liquid in which nucleic acid is eluted and oil phase-separated from the reaction liquid, (b) a control section for rotating the rotating body and moving the reaction liquid back and forth between a first region and a second region, and (c) a fluorescence measuring device for performing fluorescence measurement of the reaction liquid in a position along a rotation track of the nucleic acid amplification reaction container at the time when the rotating body rotates.. .
Seiko Epson Corporation
01/29/15
20150031035
new patent

Method and device for collection and amplification of circulating nucleic acids


Provided herein are methods for the collection and amplification of circulating nucleic acids from a non-cellular fraction of a biological sample. Circulating nucleic acids are extracted from the non-cellular fraction and are circularized to generate single-stranded nucleic acid circles, which are then subsequently amplified by rolling circular amplification using random primers to produce an amplified library.
General Electric Company
01/29/15
20150031023
new patent

Method of detecting nucleic acids containing a genetic variation


Provided are a composition or a kit for detecting a nucleic acid with genetic variation including a first amplification blocking nucleic acid and a second amplification blocking nucleic acid, and a method of detecting a nucleic acid with genetic variation by using the same. Based on the above, a nucleic acid with genetic variation can be detected with high sensitivity and accuracy..
Samsung Electronics Co., Ltd.
01/29/15
20150031015
new patent

Identification of poliovirus strains


The present invention relates to methods for identifying and/or distinguishing polioviral strains, in particular polioviral strains used in vaccine production. The methods are based on selective hybridisation with oligonucleotides, i.e.
En Sport
01/29/15
20150030217
new patent

Signal strength enhancement in a biometric sensor array


A biometric imager may comprise a plurality of sensor element traces formed in or on a sensor substrate which may comprise at least a portion of a display screen defining a biometric sensing area and forming in-active pixel locations; an auxiliary active circuit formed in or on the sensor substrate on the periphery of the biometric sensing area and in direct or indirect electrical contact with the sensor element traces; and providing a signal processing interface to a remotely located controller integrated circuit. The sensor element traces may form a portion of one dimensional linear sensor array or pixel locations in a two dimensional grid array capacitive gap biometric imaging sensor.
Synaptics Incorporated
01/29/15
20150030183
new patent

Boost converter voltage controlled based on audio signal


Audio amplification may be improved by controlling an audio amplifier based on the audio signal being amplified. For example, when the audio signal level increases or decreases, a boost voltage provided to an audio amplifier by a boost converter may also be increased or decreased.
Cirrus Logic, Inc.
01/29/15
20150029965
new patent

Radio station and processing user data with radio station


A radio station (1) includes a first part (1a) and a second part (1b). The second part (1b) can be arranged so as to be physically separated from the first part (1a) and is connected to the first part (1a) via a transmission line (40) so as to be able to communicate with the first part.
Nec Corporation
01/29/15
20150029251
new patent

Fluid ejection device and fluid ejection printer with a power amplifier stopping section


A fluid ejection device includes: a modulator adapted to pulse-modulate a drive waveform signal forming a basis of a drive signal of an actuator to obtain a modulated signal; a digital power amplifier circuit adapted to power-amplify the modulated signal to obtain a power-amplified modulated signal; a low pass filter adapted to smooth the power-amplified modulated signal to obtain the drive signal; and a power amplification stopping section operating when holding a voltage of the actuator constant.. .
Seiko Epson Corporation
01/29/15
20150029141
new patent

Touch sensing apparatus and method capable of supporting hover sensing


Disclosed herein is a touch sensing apparatus capable of supporting hover sensing, including: a plurality of capacitance-voltage converters (c-v converters) outputting different voltage values depending on a change in capacitance of each of the sensing electrodes; a plurality of integrators integrating output voltages of each of the c-v converters; a first multiplexer multiplexing outputs of the plurality of integrators; a second multiplexer multiplexing the outputs of the plurality of integrators; a first differential amplification unit for touch sensing receiving an output of the first multiplexer and an output of the second multiplexer; a second differential amplification unit for hover sensing receiving the output of the first multiplexer and the output of the second multiplexer; and a control unit sensing a touch event or a hover event, thereby removing a common noise to accurately sense both the touch event and the hover event.. .
Samsung Electro-mechanics Co., Ltd.
01/29/15
20150028870
new patent

Two-channel magnetic resonance imaging


A two-channel magnetic resonance tomography system is provided with a regulation circuit for an amplification system in order to be able to take into account different load situations of the mri system in a flexible and efficient manner. It is thus possible to improve the mri measurements greatly if the mri system is set to the respective load situation beforehand by an idle state measurement.
01/22/15
20150024972

Selective nucleic acid amplification from nucleic acid pools


Provided herein are nucleic acids and methods for selectively amplifying in parallel tens of thousands of high quality oligonucleotides without common sequences. The resultant oligonucleotides can be used for a variety of purposes and applications including but not limited to dna nano structure synthesis..
President And Fellows Of Harvard College
01/22/15
20150024959

Method for amplifying cdna derived from trace amount of sample


The problem to be solved by the present invention is to provide a method for preparing a sample for comprehensively and accurately analyzing gene expression in a single cell or a few cells, for example, by a large-scale dna sequencer. The present invention relates to a method for amplifying cdna from mrna in a cell, comprising: (1) capturing mrna derived from the cell by a first dna probe containing a first tag sequence and a poly t sequence and being immobilized to a solid carrier in a single reaction vessel, and synthesizing a first strand cdna from the mrna by a reverse transcription reaction; (2) removing a reaction reagent from the reaction vessel while keeping the first strand cdna synthesized onto the solid carrier in the reaction vessel; (3) adding a polynucleotide sequence consisting of one type of nucleotides to 3′ terminal of the first strand cdna on the solid carrier; (4) hybridizing a second dna probe containing a second tag sequence and a complementary sequence to the polynucleotide sequence with the cdna to which the polynucleotide sequence is added, and synthesizing a second strand cdna; and (5) performing a dna amplification reaction using the second strand cdna synthesized on the solid carrier as a template..
Hitachi, Ltd.
01/22/15
20150024946

Method of determining hpv integration site in genome of human tissue sample, system and use thereof


Disclosed are a method of determining an hpv integration site in a genome of a human tissue sample and a system thereof. The method comprises: subjecting genome dna of the human tissue sample to a first sequencing, to obtain a sequencing result; determining dna fragments containing both hpv sequence and human genome sequence, based on the sequencing result; determining a pair of amplification primers based on the dna fragments containing both hpv sequence and human genome sequence, subjecting the genome dna of the human tissue sample to pcr amplification using the pair of amplification primers, to obtain pcr product; and subjecting the pcr product to a second sequencing, to determine the integration site in a genome of the human tissue sample.
Bgi Shenzhen
01/22/15
20150024507

Biomarker sensing based on nanofluidic amplification and resonant optical detection


Provided is a sensor platform that includes a substrate, a plurality of nanochannels disposed on the substrate, and a plurality of electrodes, a waveguide disposed on the substrate and an analysis chamber and a reference chamber disposed on the substrate. Each electrode extends substantially across a width of the plurality of nanochannels.
Stc. Unm
01/22/15
20150024436

Sample preparation, processing and analysis systems


This disclosure provides an integrated and automated sample-to-answer system that, starting from a sample comprising biological material, generates a genetic profile in less than two hours. In certain embodiments, the biological material is dna and the genetic profile involves determining alleles at one or a plurality of loci (e.g., genetic loci) of a subject, for example, an str (short tandem repeat) profile, for example as used in the codis system.
Integenx Inc,
01/22/15
20150024434

Method for obtaining fab fragments from single antibody producing cells by multiplexed cpr in combination with taqman probes


Herein is reported a method for a multiplex one tube real-time reverse-transcriptase gene-specific polymerase chain reaction for the amplification and quantification of cognate igg heavy and light chains encoding nucleic acids (human igg isotype) from a single cell.. .
Hoffmann-la Roche Inc.
01/22/15
20150024414

Amplification of biological targets via on-chip culture for biosensing


The present invention, in part, relates to methods and apparatuses for on-chip amplification and/or detection of various targets, including biological targets and any amplifiable targets. In some examples, the microculture apparatus includes a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating.
Sandia Corporation
01/22/15
20150024397

Monitoring recombinase polymerase amplification mixtures


A process includes providing a mixture that includes a recombinase, a single-strand binding protein, and one or more oligonucleotides; and detecting particles in the reaction mixture.. .
Alere San Diego, Inc.
01/22/15
20150024387

Methods for the reduction of stutter in microsatellite amplification


The invention provides a method for reducing stutter in the amplification of a microsatellite comprising the steps of providing a sample comprising a microsatellite having a g+c content of 50% or less; contacting the sample with at least one enzyme having nucleic acid polymerase activity; and incubating the sample with the enzyme for a sufficient amount of time and under conditions sufficient to amplify the microsatellite; wherein the incubation is performed in the presence of an amount of betaine, sorbitol or mixtures thereof, effective to reduce stutter relative to the amount of stutter observed in the absence of betaine and/or sorbitol. The invention also provides compositions containing betaine and/or sorbitol, kits for amplifying microsatellites having a g+c content of 50% or less, and methods of using all of the foregoing..
Applied Biosystems, Llc
01/22/15
20150024386

Method and rapid test for the detection of specific nucleic acid sequences


A universally usable method for specific detection of target nucleic acid sequences, which method can be performed very rapidly and also simply and furthermore which does not need any expensive instrumental systems. The method is intended to be suitable as a molecular genetic rapid test and to respect the requirements of diagnostic specificity assurance.
Aj Innuscreen Gmbh
01/22/15
20150024383

Assay methods for mdv-1


A method for the quantification of a vaccine strain and/or a virulent strain of marek's disease virus serotype-1 (mdv-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological sample of (i) to real-time quantitative pcr (qpcr) comprising: (a) amplification of a region of the pp38 gene within the nucleic acid sample of (i), said region containing a consistent single nucleotide polymorphism (snp) difference between vaccine and virulent strains of mdv-1, and (b) contacting the amplified nucleic acid of (a) with a detectable nucleic acid probe specific for the snp of the vaccine strain of mdv-1 and/or a detectable nucleic acid probe specific for the snp of the virulent strain of mdv-1; and (iii) measuring changes in the detectable signal produced by the probe of (ii). Methods are also provided for the absolute quantification is of vaccine and virulent viruses..
Zoetis W Llc
01/22/15
20150024382

Assay methods for mdv-1


A method for the quantification of a vaccine strain and/or a virulent strain of marek's disease virus serotype-1 (mdv-1) in a sample from a bird, comprising the steps of: (i) providing a biological sample from the bird and optionally isolating nucleic acid from the biological sample; (ii) subjecting the biological sample of (i) to real-time quantitative pcr (qpcr) comprising: (a) amplification of a region of the pp38 gene within the nucleic acid sample of (i), said region containing a consistent single nucleotide polymorphism (snp) difference between vaccine and virulent strains of mdv-1; and (b) contacting the amplified nucleic acid of (a) with a detectable nucleic acid probe specific for the snp of the vaccine strain of mdv-1 and/or a detectable nucleic acid probe specific for the snp of the virulent strain of mdv-1; and (iii) measuring changes in the detectable signal produced by the probe of (ii). Methods are also provided for the absolute quantification of vaccine and virulent viruses..
Zoetis W Llc
01/22/15
20150024378

Analysis of dna-containing samples and resolution of mixed contributor dna samples


Methods for analyzing dna-containing samples are provided. The methods can comprise isolating a single genomic equivalent of dna from the dna-containing sample to provide a single isolated dna molecule.
The Johns Hopkins University
01/22/15
20150024377

Apparatus comprising magnetically actuated valves and uses thereof


The present invention, in part, relates to an apparatus having a single-use, normally-closed fluidic valve that is initially maintained in the closed position by a valve element bonded to an adhesive coating. The valve is opened using a magnetic force.
Sandia Corporation
01/22/15
20150023526

Process for adjusting the sound volume of a digital sound recording


The present invention relates to a process for adjusting the sound volume of a digital sound recording characterised in that it comprises: a step consisting of determining, in absolute values, for a recording, the maximum amplitude values for sound frequencies audible for the human ear, a step consisting of calculating the possible gain for a specified sound level setting, between the maximum amplitude value determined above and the maximum amplitude value for all frequencies combined, a step consisting of reproducing the recording with a sound card by automatically adjusting the amplification gain level making it possible to obtain a sound level for the recording of a specified value so that it corresponds to the gain calculated for this recording.. .
Touchtunes Music Corporation
01/22/15
20150023375

Laser device


A laser device 1 demultiplexes seed light l0 into a plurality of beams of laser light l1 and then continuously optically amplifies the plurality of beams of the laser light l1 with an amplifier 14. Therefore, its amplification factor can be set higher than that in the case of amplifying pulsed laser light.
Hamamatsu Photonics K.k.
01/22/15
20150022702

Analog-to-digital converter, image sensor including the same, and image processing device including the image sensor


An analog-to-digital converter includes a gain amplification unit configured to receive a pixel signal at a first node and to amplify a gain of the pixel signal, a first capacitor connected between the first node and a second node, an amplifier configured to receive and amplify a signal output from the gain amplification unit and the first capacitor, and a conversion circuit configured to convert an output signal of the amplifier to a digital signal based on a reference signal and output the digital signal as a first output signal.. .
Samsung Electronics Co., Ltd.
01/22/15
20150022568

Image display device


The white balance for a high brightness region and a low brightness region is improved in an image display device using mems and a laser light source. An image processing unit of the device superposes a signal based on a first measured value of a light quantity at a first temperature on a picture signal, during its blanking period, which is supplied to the laser light source, and superposes a high frequency signal on the picture signal during its effective scanning period.
Hitachi Media Electronics Co., Ltd.
01/22/15
20150022267

Apparatus and methods for electronic amplification


Apparatus and methods for electronic amplification are provided. In one embodiment, an amplifier includes first and second input terminals, an amplification circuit, a feedback circuit, and a current mirror.
Analog Devices, Inc.
01/22/15
20150022056

System for driving a piezoelectric load and making same


A driver system comprises a direct current (dc) voltage source and a first bi-directional dc-to-dc converter having a primary side coupled to the dc voltage source and a secondary side and configured to convert a first voltage on the primary side to a second voltage on the secondary. The driver system also comprises a second bi-directional dc-to-dc converter having a primary side coupled to the dc voltage source and a secondary side coupled to the secondary side of the first bi-directional dc-to-dc converter and configured to convert the first voltage on the primary side to a third voltage on the secondary.
General Electric Company
01/15/15
20150017933

Transmitter and method with rf power amplifier having control loop stabilized bias


A transmitter (32) generates a time-varying stabilized bias signal (82) from which an amplifier-generated, sub-rf distortion signal (26) has been canceled. The distortion signal (26) is a byproduct of amplification and is generated due to imperfect linearity and/or other characteristics of a linear rf power amplifier (36).
Crestcom, Inc.
01/15/15
20150017932

Signal amplification apparatus and method


A signal amplification apparatus includes a first modulator configured to receive an envelope signal, use a predetermined reference level to separate the received envelope signal into a first period and a second period, digitally modulate a signal of the second period to output the digitally modulated signal to a first output terminal, and output a signal of the first period to a second output terminal. Further, the signal amplification apparatus includes a second modulator configured to mix the digital modulated signal input through the first output terminal with a phase modulated carrier signal; an envelope modulator configured to output the signal of the first period as a power supply signal; and a power amplifier configured to amplify the mixed signal output by the second modulator to output the amplified signal..
Electronics And Telecommunications Research Institute
01/15/15
20150017709

Method for detecting the presence of a target nucleic acid sequence in a sample


A method comprises loading a sample portion into a sample chamber which comprises means for minimizing diffusion of the sample portion, subjecting the sample portion to an amplification step, and determining whether the sample portion contains at least one molecule of a target nucleic acid. If the sample portion contains a single molecule of the target nucleic acid, the sample portion would attain a detectable concentration of the target nucleic acid after a single round of amplification.
Health And Human Services, United States Of America, As Represented By The Secr
01/15/15
20150017688

Compositions and methods for reverse transcriptase-polymerase chain reaction (rt-pcr)


The present invention is directed to compositions and methods useful for the amplification of nucleic acid molecules by reverse transcriptase-polymerase chain reaction (rt-pcr). Specifically, the invention provides compositions and methods for the amplification of nucleic acid molecules in a simplified one- or two-step rt-pcr procedure using combinations of reverse transcriptase and thermostable dna polymerase enzymes in conjunction with sulfur-containing molecules or acetate-containing molecules (or combinations of such sulfur-containing molecules and acetate-containing molecules), and optionally bovine serum albumin.
Life Technologies Corporation
01/15/15
20150017654

Absolute pcr quantification


The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (pcr) on said volumes, detecting pcr amplification products, analyzing said detected pcr amplification products, performing absolute quantification of the pcr target and presenting said quantification results..
The Research Foundation For The State University Of New York
01/15/15
20150017653

Absolute pcr quantification


The present application provides methods and devices for absolute quantification of polymerase chain reaction target nucleic acids. In particular, the methods and devices of the present application provide for splitting a nucleic acid sample to be analyzed into small, isolated volumes, conducting the method of polymerase chain reaction (pcr) on said volumes, detecting pcr amplification products, analyzing said detected pcr amplification products, performing absolute quantification of the pcr target and presenting said quantification results..
The Research Foundation For The State University Of New York
01/15/15
20150017652

Compositions and measuring and calibrating amplification bias in multiplexed pcr reactions


Compositions and methods are described for standardizing the dna amplification efficiencies of a highly heterogeneous set of oligonucleotide primers as may typically be used to amplify a heterogeneous set of dna templates that contains rearranged lymphoid cell dna encoding t cell receptors (tcr) or immunoglobulins (ig). The presently disclosed embodiments are useful to overcome undesirable bias in the utilization of a subset of amplification primers, which leads to imprecision in multiplexed high throughput sequencing of amplification products to quantify unique tcr or ig encoding genomes in a sample.
Adaptive Biotechnologies Corporation
01/15/15
20150017650

Reagents and methods for autoligation chain reaction


The invention relates to the amplification of specific target nucleic acids. The invention provides methods, reagents, and kits for carrying out such amplification via the autoligation chain reaction (acr)..
01/15/15
20150017646

Systems and methods for multiplex analysis of pcr in real time


The present invention provides methods and systems for real-time measurements of pcr with multiplexing capability. Certain embodiments relate to methods and systems that use fluorescently encoded superparamagnetic microspheres for the immobilization of amplification products during the pcr process, and an imaging chamber of a measurement device that is also capable of controllable thermal cycling for assisting the pcr process..
Luminex Corporation
01/15/15
20150017645

Qualitative and quantitative detection of microbial nucleic acids


The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example the polymerase chain reaction.
Roche Molecular Systems, Inc.
01/15/15
20150017635

Direct capture, amplification and sequencing of target dna using immobilized primers


Certain embodiments provide a method for capturing a genomic fragment. The method may comprise: obtaining a substrate comprising a first population of surface-bound oligonucleotides and a second population of surface-bound oligonucleotides; hybridizing a first member of the first population of surface-bound oligonucleotides to a selection oligonucleotide comprising a region that hybridizes with the first member and a region that contains a genomic sequence; extending the first member of the first population of surface-bound oligonucleotides to produce a support-bound selection primer that comprises a sequence that is complementary to the genomic sequence; hybridizing the support-bound selection primer to a nucleic acid fragment comprising the genomic sequence; extending the support-bound selection primer to produce an extension product that contains a sequence that flanks the genomic sequence, e.g., in a genome; and amplifying the extension product on the substrate..
The Board Of Trustees Of The Leland Stanford Junior University
01/15/15
20150017318

Method for fabricating microchip for nucleic acid amplification reaction


Provided is a method for fabricating a microchip for nucleic acid amplification reaction that is capable of simple and highly accurate analysis. Provided is a method for fabricating a microchip for nucleic acid amplification reaction, the method including a solidification step of drying a reagent solution including at least a part of substances required for a nucleic acid amplification reaction, and a containment step of arranging the reagent solution including the solidified substance in wells that serve as a reaction site for a nucleic acid amplification reaction.
Sony Corporation
01/15/15
20150015939

Optical pumping few-mode fiber amplification


An optical pumping apparatus for few-mode fiber amplification is provided. The optical pumping apparatus includes an optical pump source configured to generate an optical pump; an optical power divider configured to divide an optical power of the optical pump from the optical pump source so as to output several optical pumps with uniformly distributed optical power; and a modal multiplexer configured to receive the optical pumps from the optical power divider through a plurality of single-mode fibers, multiplex the received optical pumps, apply a multiplexed optical pump to each mode of a few-mode fiber (fmf) amplifier, and adjust a gain difference among modes, wherein the fmf amplifier obtains a gain by amplifying an optical signal with the optical pump..
Electronics And Telecommunications Research Institute
01/15/15
20150015937

Methods and systems for nonlinear optical wave-mixing


A system for conversion or amplification using quasi-phase matched nonlinear optical wave-mixing comprises a first radiation source for providing a pump radiation beam, a second radiation source for providing a signal radiation beam, and a bent structure for receiving the pump radiation beam and the signal radiation beam. The radiation propagation portion of the bent structure is made of a uniform nonlinear optical material and the radiation propagation portion comprises a dimension taking into account the spatial variation of the nonlinear optical susceptibility along the radiation propagation portion as experienced by radiation travelling along the bent structure for obtaining quasi-phase matched nonlinear optical wave-mixing in the radiation propagation portion.
Vrije Universiteit Brussel
01/15/15
20150015760

Imaging unit, imaging apparatus, and computer readable medium storing thereon an imaging control program


When the amplification ratio is low and strong incident light causes a large charge, the signal retrieved from regions where the incident light is weak is also weak, but when the amplification ratio is high in regions where the incident light is weak, the signal retrieved from regions where the incident light is strong becomes saturated. Therefore, the dynamic range of the imaging unit is narrow.
Nikon Corporation
01/15/15
20150015332

Method and circuit for controlled gain reduction of a gain stage


The present document relates to multi-stage amplifiers, such as linear regulators or linear voltage regulators (e.g. Low-dropout regulators) configured to provide a constant output voltage subject to load transients.
Dialog Semiconductor Gmbh
01/15/15
20150015331

Method and circuit for controlled gain reduction of a differential pair


The present document relates to multi-stage amplifiers, such as linear regulators or linear voltage regulators (e.g. Low-dropout regulators) configured to provide a constant output voltage subject to load transients.
Dialog Semiconductor Gmbh
01/15/15
20150015329

Radio frequency composite class-s power amplifier having discrete power control


A composite amplifier providing digitally selectable amplification includes a plurality of channels and a combiner. Each of the channels includes a digitally controllable selector, a class-s power amplifier, and bandpass filter.
Lsi Corporation
01/15/15
20150015318

Transmitter with high frequency amplification


A transmitter may include a first path configured to receive a signal, to attenuate the low frequency components of the signal, and to output the low frequency component attenuated signal. The transmitter may further include a second path configured to receive the signal, to amplify the signal, and to output the amplified signal.
Fujitsu Limited
01/15/15
20150015307

Comparator and amplifier


A comparator has a differential pair circuit and a current control circuit. The differential pair circuit has first and second comparator transistors, and is arranged to compare a first input and a second input according to a clock signal to generate a result indicating whether a difference of the first and second inputs exceeds an internal offset.
Mediatek Inc.
01/15/15
20150015305

Dynamic circuitry using pulse amplification to reduce metastability


Synchronisation circuitry 2 comprises a first dynamic circuit stage 4 generating a first stage state signal which is pulse amplified by pulse amplifying circuitry 8 to generate a pulse amplified signal. The pulse amplified signal is supplied to a second dynamic circuit stage 6 where it is used to control generation of a second stage state signal.
01/15/15
20150015228

Control device, digital control power supply, and control method


In a digital control power supply, a mode control unit measures a first frequency and a second frequency for a difference between a second digital value and a target value. Based on the measured first frequency and second frequency and a predetermined threshold set to the first and second frequencies, the mode control unit determines whether an amplification factor for use in amplification processing by an amplifier is maintained at a current amplification factor or is changed to an amplification factor which is larger or smaller by 1 than the current amplification factor.
Renesas Electronics Corporation
01/15/15
20150015175

Position detecting apparatus and driving system


The position detecting apparatus includes a comparing part that compares the value of the digital signal output from the ad converter and a reference value that is based on a preset reference amplitude at the timings and outputs a control signal responsive to a result of the comparison. The position detecting apparatus includes an amplitude controlling part that controls amplification factors of the first amplifier and the second amplifier in such a manner that the value of the digital signal output from the ad converter comes closer to the reference value in response to the control signal output from the comparing part..
Kabushiki Kaisha Toshiba
01/15/15
20150013641

Fuel combustion enhancement apparatus of internal combustion engine


A fuel combustion enhancement apparatus of an internal combustion engine, which is capable of greatly reducing fuel and improving combustion efficiency and torque and reducing exhaust gas, includes a power source terminal, a conductor plate 10 for gas activation, an amplifier 30, and a gas activation enhancement device 20 which includes a frequency resonance coil power source 22, a local oscillation power source, a detection circuit 23, a power amplification circuit 24, a power amplification ic 27, and an amplifier power source 28 connected between the power source terminal and the conductor plate. The conductor plate 10 includes a coil unit 12, and copper plates 14 are electrically connected between both ends of the coil unit 12, and auxiliary plates 16 made of materials having a different standard electrode potential value from materials of the copper plates are disposed at bottoms of the copper plates 14..


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Amplification topics: Amplification, Nucleic Acid, Nucleotide, High Resolution, Modulation, Feedback Signal, Nanoparticle, Semiconductor, Raman Amplifier, Resonance Frequency, User Interface, Transmitter, Methylation, Sample Preparation, Sequencing

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