|| List of recent Amplification-related patents
|System and method for outcome tracking and analysis|
Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information.
|Multivolume devices, kits and related methods for quantification and detection of nucleic acids and other analytes|
Provided are devices comprising multivolume analysis regions, the devices being capable of supporting amplification, detection, and other processes. Also provided are related methods of detecting or estimating the presence nucleic acids, viral levels, and other biological markers of interest..
|Method and kit for characterizing rna in a composition|
V. Sequencing the amplification products by means of next generation sequencing..
|Apparatus for regulating transmission power of repeater in long term evolution system|
The present invention relates to an apparatus capable of flexibly regulating coverage of a repeater in a long term evolution system (hereinafter referred to as an lte system). The present invention provides an apparatus for regulating transmission power of a repeater in an lte (long term evolution) system, the apparatus including a sink signal detector that detects a sink signal of a reception signal received through an if/rf receiver of the repeater, a sink signal power measurer that measures a size of power of the sink signal detected through the sink signal detector, and an amplification controller that calculates a gain of an amplifier of the repeater for maintaining coverage of the repeater based on the size of the power of the sink signal measured through the sink signal power measurer, and controls the amplifier of the repeater according to the calculated gain.
|Method for signal amplification in biosensor-based system for rapidly detecting infectious agents|
A system for detecting infectious agents in biological samples in real time that includes a sample to be tested for at least one specific infectious agent; and a biosensor, wherein the biosensor is operative to detect a specific infectious agent in the sample to be tested; and wherein the biosensor emits an amplified and detectable signal when it reacts with the specific infectious agent. Signal detection is enhanced through the release of lps from the cells of the infectious agent..
|Apparatus for detecting nucleic acid amplification product in real time|
There is provided an apparatus for detecting a nucleic acid amplification product in real time, which is capable of effectively excluding or reducing apparatus error factors without using a second fluorescence signal used for correction. A plurality of wells 7a are given with temperature cycles and fluorescence strength from a nucleic acid amplification product is detected in real time in each well 7a.
|Analyte enrichment methods and compositions|
Methods and compositions for enriching a population of particles containing an analyte are disclosed. In one embodiment, enrichment beads are used that are larger in size than the beads used for amplification.
|Direct nucleic acid analysis|
The present disclosure provides methods, systems, and apparatuses for collecting and/or amplifying nucleic acids. In general, provided methods, systems, and apparatuses involve contacting a sample including a nucleic acid with a nucleic acid amplification reagent without purification of nucleic acids from the sample..
|Methods for detecting nucleic acid sequence variants|
The present invention provides methods for detecting the presence or absence of a nucleic acid variant in a target region. These methods include amplifying the target region with a forward primer and a reverse primer in the presence of a selector blocker.
|Dual bridge amplifier configuration|
An amplifier has a dual bridge design with two bridge amplifiers. A mode switch enables them to be configured in a series amplification mode.
|Methods and apparatus for all digital multi-level outphasing using bandwidth reduction|
For use in a transmitter in a wireless network, a transmitter apparatus is configured for digital multi-level outphasing. The apparatus includes a bandwidth reduction (bwr) modulator block configured to receive a phase modulated carrier and reduce a bandwidth of the phase modulated carrier using amplitude modulation.
|Method and device for the optical parametric amplification of pulses with frequency drift|
According to the invention, which is particularly applicable to laser-matter interaction, a four-wave mixing effect is used, preferably in an optical fibre (f), between each pulse (s) and the two pump signals (p1, p2); and the half-sum (fm) of the respective optical frequencies (fp1, fp2) of these signals pertains to the pulse spectrum support.. .
|Surface plasmon resonance biosensor|
An optical biosensor is provided for detecting a bio-molecular sample by goos-hänchen (gh) enhancement of aharonov-albert-vaidman (aav) amplification to a surface plasmon resonance (spr) detector. The sensor includes pre- and post-selection polarizers respectively upstream and downstream of a right-isosceles prism with a metal film and a liquid medium disposed on a diagonal side of the prism.
|Optical parametric amplification of weak signals for imaging biological tissue|
Methods and apparatus for obtaining an image of light scattering biological tissue. A series of pulses of substantially monochromatic light of a first wavelength is generated and split into two parts, of which one part illuminates a scattering biological tissue at an intensity too low to damage the tissue, while a second part is upconverted to generate a pump beam.
|Photon counting controller, radiographic imaging apparatus, and control method of photon counting controller|
The photon counting controller includes an amplification controller to charge an input electrical signal, to amplify the input electrical signal, and to discharge the charged electrical signal, a charge controller to control a charge and a discharge of the electrical signal of the amplification controller based on a received feedback signal, and a measuring controller to compare voltage of the amplified electrical signal with reference voltage and to count photons based on a result of comparison.. .
|Laser scanning code symbol reading system|
A laser scanning symbol reading system includes an analog scan data signal processor for producing digital data signals, wherein during each scanning cycle, a light collection and photo-detection module generates an analog scan data signal corresponding to a laser scanned symbol, a multi-channel parallel scan data signal processor/digitizer processes the analog scan data signal along multiple cascaded multi-stage signal processing channels, to generate digital data signals corresponding thereto, while a synchronized digital gain control module automatically processes the digital data signals in response to start of scan (sos) signals generated by a sos detector. Each signal processing channel supports different stages of amplification and filtering using a different set of band-pass filtering and gain parameters in each channel, to produce multiple digital first derivative data signals, and/or multiple digital scan data intensity data signals, having different signal amplitudes and dynamic range characteristics for use in decode processing..
|Electromagnetic wave treatment method and promoter|
A method involving exposing a substance to a promoter, the promoter being made from a liquid carrier and a metal salt component, the metal salt component, having at least (i) a magnetic susceptibility above 1000 or (ii) an ionization potential below about 500 volts, or (iii) both (i) and (ii), and applying electromagnetic wave energy to the substance while the substance is in the presence of the promoter, for a period of time and at a frequency and amplification sufficient to promote the modification of at least one physical property of the substance. A related method of treating a well in a subterranean formation, a tank or a pipeline, and the well treatment promoter composition, are also described..
|Method of amplifying a nucleic acid|
A nucleic acid amplification method is provided, along with kits useful in performing the amplification method.. .
|Constructing method of high-throughput sequencing library and use thereof|
The present invention provides a method for constructing a high-throughput sequencing library, which comprises: fragmenting genomic dna; end-repairing the dna fragments; adding a base a to the 3′ end of the end-repaired dna fragments; connecting the dna fragments having cohesive end a with a methylated adapter; carrying out hybrid capture on the connection products by using specific probes to obtain object fragments; treating the object fragments with bisulfite, to convert non-methylated cytosines to uracils; pcr amplifying the converted object fragments; and separating and purifying the amplification products, wherein the amplification products constitute the high-throughput sequencing library. The present invention also provides a method and an apparatus for identifying methylation information in specified genome regions of a sample..
|Devices, methods, and systems for nucleic acid amplification|
A microfluidic device comprising a first surface portion and a first sample retaining element, which have differing affinities to a fluid, and a method comprising supplying a sample to such a device. In some embodiments, the differing affinity is a result of plasma, ion embedding, surface charging, chemical, optical, electronic and/or electromagnetic treatment.
|Multiplexed diagnostic detection apparatus and methods|
Disclosed herein are devices configured for the amplification and detection of multiple targets from a sample, and methods of using the same. The devices disclosed herein comprise microfluidic cartridges have a first stage (amplification) and a second (detection) stage.
|Biosensor using redox cycling|
The present invention relates to a biosensor using dual amplification of signal amplification by means of enzymes coupled with signal amplification by means of redox cycling, and to the use of a technology that maintains a slow reaction state between redox cycling materials without the use of redox enzymes, and induces quick chemical-chemical redox cycling. In addition, the present invention relates to a biosensor which obtains triple amplification by inducing electrochemical-chemical-chemical redox cycling, in addition to signal amplification by means of enzymes and signal amplification by means of chemical-chemical redox cycling..
|Methods for multiplexing amplification reactions|
A two-step multiplex amplification reaction includes a first step which truncates the standard initial multiplex amplification round to “boost” the sample copy number by only a 100-1000 fold increase in the target. Following the first step the product is divided into optimized secondary single amplification reactions, each containing one of the primer sets that were used previously in the first or multiplexed booster step.
|Amplification methods to minimise sequence specific bias|
Methods for amplifying nucleic acids are provided. The methods can be used to minimise sequence specific bias caused by the preferential amplification of certain nucleic acid sequences.
|Apparatus for amplification of nucleic acids|
Described herein is a chip-based apparatus for amplifying nucleic acids, a cartridge housing the apparatus, and methods of using the apparatus for amplification of nucleic acids. More specifically, this invention provides integrated semiconductor chip, manufactured with standard semiconductor manufacturing process, with on-chip circuitry to perform thermal management and optical sensing necessary for amplification of nucleic acids.
|Chip-based sequencing nucleic acids|
A system for fast dna sequencing by amplification of genetic material within microreactors, denaturing, demulsifying, and then sequencing the material, while retaining it in a pcr/sequencing zone by a magnetic field. One embodiment includes sequencing nucleic acids on a microchip that includes a microchannel flow channel in the microchip.
|Method for the detection of nucleic acid synthesis and/or amplification|
The present invention relates to a method for the detection of nucleic acid synthesis and/or amplification, characterised in that the method includes adding at least one colorimetric metal indicator and at least one bland magnesium chelator to a reaction mixture for nucleic acid amplification. The present invention further relates to a kit for carrying out such a method and to the use thereof in the health, food and agricultural or veterinary fields..
|Simplified gating method for sealing and flow control in micro and nano devices|
A biochip for multiplex genetic identification is disclosed. An biochip for separating and detecting a plurality of dna fragments includes a set of inputs and chambers for receiving a sample matrix of genetic material and reagents needed to conduct a polymerase chain reaction amplification of the genetic material.
A gain medium (7) arranged in the amplification section of the first waveguide and suitable for producing a stimulated light transmission, and an optical detector (8) coupled to the reception section of the second waveguide.. .
When a chamber of an oscillator and one or more amplifiers is to be replaced at the timing when a predetermined period elapses, one of the chambers of the oscillator and the amplifiers having a low allowable deterioration limit is detached and this chamber is attached in place of one of the chambers of the oscillator and the amplifiers other than the one having the low allowable deterioration limit. Thus, the chamber which has been used in one of the oscillator and amplifiers having a low allowable deterioration limit and has not reached the limit of deterioration is reused in one of the oscillator and the amplifiers other than the one having the low allowable deterioration limit.
|Imaging device, method for controlling imaging device, and storage medium storing a control program|
An imaging apparatus (10) includes: an image pickup device (14) including plural photoelectric conversion elements arrayed in first and second directions; an amplification means that treats (k×l) pixels as respective common pixels and amplifies an image capture signal for each of the common pixels; a color filter that is provided with a repeatedly disposed basic array pattern or first and second filters placed in a predetermined pattern of (n×m) pixels; and an image processing section (20) and a drive section (22) that perform charge sweeping by applying sequential shutter pulses to the image pickup device (14) in turn to each pixel, or to each scan line, or to each of plural pixels on a scan line, that read pixel signals of the plural pixels at a set cycle, that, from the read pixel signals, generate line image data of pixels that are arrayed running along the second direction at a cycle of from k pixels to n pixels in the first direction, and that generate image data based on the line image data.. .
|Systems and methods of rf power transmission, modulation, and amplification, including control functions to transition an output of a miso device|
Embodiments of the present invention include a method and system for control of a multiple-input-single output (miso) device. For example, the method includes partitioning a waveform constellation space into a plurality of regions, where each region of the plurality of regions is associated with one or more control functions of the miso device.
|Instrumentation amplifier with rail-to-rail input range|
A system and method for adjusting a common mode output voltage in an instrumentation amplifier is provided. In one aspect, the common mode output voltage is increased or decreased with respect to the common mode input voltage to enable high amplification of the signal input to the instrumentation amplifier.
|Flash translation layer with lower write amplification|
A method of associating a logical block address with a physical location in a non-volatile memory includes (a) in response to a write request comprising a respective logical block address in a logical block address space and respective data to be written to the non-volatile memory, determining a physical location in the non-volatile memory to store the respective data of the write request, (b) adding an entry to a journal, such that the added entry trails any entries already in the journal and the added entry has a respective logical block address field set to the respective logical block address of the write request and a respective physical location field set to the determined physical location, and (c) updating one of a plurality of second-level map pages in a two-level map according to the respective logical block address of the write request with the determined physical location.. .
|Voice input/output device, method and programme for preventing howling|
A voice separation means 82 separates an input voice of a volume adjusted by an input volume adjustment means 81, into a voice recognition voice and a monitoring voice. A monitoring volume adjustment means 83 adjusts a volume of the monitoring voice.
|Methods and apparatus for the control of adenosine triphosphate synthase activity within living organisms, and conditioning of water-based fluids and substances using magnetic field exposures or their withdrawal|
The present invention relates to the control by magnetic fields (mf) of the activity of the mitochondrial enzyme adenosine triphosphate synthase (atps). Elimination of alternating and static mfs allows atps activity amplification (atpsa), while a variety of mf frequency-intensity combinations interfere to various degrees with atps function (atpsi).
|Transmitter with class e amplifier|
According to one embodiment, a transmitter includes a first buffer, a second buffer, a logic circuit, and a class e power amplifier. The first buffer receives a first sinusoidal signal, and converts the first sinusoidal signal to a first rectangular wave signal.
|Nanocrystal based biomolecule detection|
A new signal amplification method exploiting the dense atom packing in metallic nanocrystals has been developed for detecting target substances. By dissolving nanocrystals to individual ions that are stoichiometrically converted to chromophores and quantified photometrically, extremely high signal amplification can be achieved.
|Method of preparing sample for nucleic acid amplification reaction, nucleic acid amplification method, and reagent and microchip for solid phase nucleic acid amplification reaction|
Provided is a method of preparing a sample for nucleic acid amplification reaction, including: a procedure of dissolving a solid phase reagent at least containing dna polymerase, cyclodextrin, and a binder, in a liquid containing a nucleic acid.. .
|Phi29 dna polymerase mutants having increased thermostability and processivity|
Mutants of bacteriophage phi29 dna polymerase with increased protein stability and increased half-life, compared to wild type dna polymerase. The disclosed mutants are more stable in reaction mixtures with or without dna.
|Method for the production of human thrombin and uses thereof|
The present invention disclosed the cloning and the purification of a mutant of prethrombin-2, which contains a thrombin cleavage site instead of a factor xa cleavage site. The stable mutant prethrombin-2 is able to convert itself autocatalytically into active α-thrombin in the absence of ecarin or factor xa.
|Selective amplification and detection of mutant gene alleles|
The present invention provides methods for selectively amplifying a mutant allele of a gene. These methods include (a) contacting a sample containing a mutant and a normal allele of a gene with at least one primer that selectively modifies the normal allele of the gene and causes further amplification of the normal allele to fail or to be substantially reduced; and (b) selectively amplifying the mutant allele of the gene or a portion thereof.
|Methods of detecting mutations and epigenetic changes|
Disclosed are methods for assessing the methylation and mutation status of nucleic acid in a sample. The methods provide for methylation-dependent modification of the nucleic acid in a sample, and subsequently nucleic acid amplification processes to distinguish between mutated and non-mutated target sequence..
|Hearing assistance apparatus having single multipurpose control device and method of operation|
A hearing assistance device has one multipurpose control device that operates in an algorithm selection mode and a daily use mode. In the algorithm selection mode, the multipurpose control device is used to switch between amplification algorithms and select one of the algorithms to be implemented in an audio processing program.
|Optical pulse compressing based on chirped fiber bragg gratings for pulse amplification and fiber lasers|
Techniques and devices for using a chirped fiber bragg grating to compress amplified laser pulses.. .
|Apparatus and methods for radio frequency signal boosters|
Provided herein are apparatus and methods for radio frequency (rf) signal boosters. In certain implementations, a multi-band signal booster is provided for boosting the uplink and downlink channels of at least a first frequency band and a second frequency band.
|Solid-state imaging device|
According to one embodiment, a solid-state imaging device includes a pixel array unit where pixels are disposed in a matrix and a column amplifying circuit that is disposed at an end of the pixel array unit and amplifies a unit signal of a unit pixel read from each pixel with at least first and second amplification factors, and outputs a plurality of amplified signals.. .
|Pipeline analog-to-digital converter|
A pipeline analog-to-digital converter is disclosed which includes at least one periodic unit consisting of two adjacent stages that jointly use two capacitor networks of the same structure. Each of the capacitor networks includes two identical capacitors, two switches and four terminals.
|Doherty power amplification apparatus and method|
A multi-way doherty power amplifier, dpa, is disclosed, comprising a first path comprising a carrier amplifier or at least one carrier amplifier segment partitioned from the carrier amplifier; a second to n-th paths each comprising at least one carrier amplifier segment and/or at least one peaking amplifier segment partitioned from a peaking amplifier; and a power splitter for splitting an input power signal to each of the at least one carrier amplifier segment and/or at least one peaking amplifier segment in a same path, wherein n is an integer not less than 2; a signal preparation unit configured for generating separately input power signal for the first path and each of the second path to n-th paths; and an impedance inverting network configured for combining output signal power from each path. The performance of each amplifier cell can be maximized independently without any compromises made for each other..
|Yield traits for maize|
Methods for introgressing an allele of interest of a locus associated with a yield trait into zea mays germplasm are provided. In some embodiments, the methods include providing a zea mays plant that contains an allele of interest of a locus associated with a yield trait, wherein the locus associated with the yield trait is identifiable by pcr amplification of a zea mays nucleic acid with a pair of oligonucleotides primers as disclosed herein, and introgressing the allele of interest into zea mays germplasm that lacks the allele.
|Molecular nets on solid phases|
Disclosed is a covalently-linked multilayered three-dimensional matrix comprising capture molecules, linkers and spacers (referred to as a molecular net) for specific and sensitive analyte capture from a sample. Also disclosed herein is a molecular net comprising covalently-linked multilayered three-dimensional matrix comprising more than one type of capture molecule and more than one type of linker and may comprise one or more spacer for specific and sensitive capture of more than one type of analyte from a sample.
|Selective detection of norovirus|
A process for detecting norovirus nucleic acid in a sample is provided including producing an amplification product by amplifying a norovirus nucleotide sequence using a forward primer of seq id no: 1, 4, or 10 and a reverse primer of seq id no: 2, 5, or 11, and detecting the amplification product to detect norovirus in the sample. Also provided are reagents and methods for detecting and distinguishing gi or gil norovirus from other infectious agents.
|Broad detection of dengue virus serotypes|
Processes for detecting dengue virus (denv) nucleic acid in a sample are provided including producing an amplification product by amplifying denv nucleotide sequence and detection of an amplification by hybridization of a probe or other technique. The processes use primers or probes with introduced mutations and or degenerate bases that provide excellent superiority in detection and serotyping of denv in a sample..
|Detection of nucleic acid reactions on bead arrays|
The present invention is directed to methods and compositions for the use of micro sphere arrays to detect and quantify a number of nucleic acid reactions. The invention finds use in genotyping, i.e.
|Method for high-throughput aflp-based polymorphism detection|
The invention relates to a method for the high throughput discovery, detection and genotyping of one or more genetic markers in one or more samples, comprising the steps of restriction endonuclease digest of dna, adaptor-ligation, optional pre-amplification, selective amplification, pooling of the amplified products, sequencing the libraries with sufficient redundancy, clustering followed by identification of the genetic markers within the library and/or between libraries and determination of (co-)dominant genotypes of the genetic markers.. .
|Gaming device having a haptic-enabled trigger|
A haptic peripheral comprising a housing, a user input element, a position sensor coupled to the user input element, and an actuator located within the housing and coupled to the user input element. The position sensor is configured to detect a position of the user input element and is configured to send the position to a processor.
|Multiple input single output device with vector signal and bias signal inputs|
Methods and systems for vector combining power amplification are disclosed herein. In one embodiment, a plurality of signals are individually amplified, then summed to form a desired time-varying complex envelope signal.
|Assembly comprising a reaction vessel and a sample matrix, sample matrix comprising an upper adsorbent layer and a lower lateral flow layer|
An assembly and related methods are described for the preparation and processing of samples in molecular biology assays and nucleic acid amplification reactions. The assembly allows rapid and easy processing with reduced sample handling compared to known sample preparation apparatus and methods.
|Methods for suppression pcr|
Provided herein are approaches for the detection, identification, and/or selective amplification of specific target species or target variants of nucleic acid sequences, even within an excess of unwanted similar sequences or variants. These approaches include methods, assays, and kits for suppression pcr that require, in part, dna polymerase that lacks 5′-3′ exonuclease activity, and a pcr primer, termed a forward selective primer or a nunchaku primer.
|Molecular assay for the amplification and detection of kpc genes responsible for high-level resistance to carbapenem in gram negative bacteria|
Methods and kits useful for the detection and identification of carbapenem-resistant pathogens harboring carbapenemase-encoding nucleic acids. Said methods comprise pcr amplification of a target region of the beta-lactamase encoding klebsiella pneumoniae carbapenemase genes (blakpc) and variants thereof with a primer set comprising seq id nos: 1 and 2, and variants thereof.
|Immunohistochemistry detection method|
The invention provides compositions and methods for the detection of targets in a sample; in particular, an immunohistochemistry (ihc) sample. Probes and detectable labels may be provided in multiple layers in order to increase the flexibility of a detection system, and to allow for amplification to enhance the signal from a target.
|Method for assembling multiple target loci to single nucleic acid sequence|
A method for assembling multiple target loci to a single assembled nucleic acid sequence involves assembling the multiple target loci to a single assembled nucleic acid sequence through two polymerase chain reactions (pcrs). A pair of primers for a primary amplification include a target-specific sequence and a 5′-flanking assembly spacer sequence.
Methods and reagents for detection and analysis of nucleic acids are provided. Certain methods involves an encoding amplification in which a target sequence is associated with probe-binding sequences and optionally with indexing sequences, (2) an optional distribution step in which the product of the encoding amplification is split into multiple aliquots, and (3) a decoding and detection step in which the presence, absence, quantity, or relative amount of the target sequence in the aliquots is determined.
|Suppression of stimulated brillouin scattering in higher-order- mode optical fiber amplifiers|
An hom-based optical fiber amplifier is selectively doped within its core region to minimize the presence of dopants in those portions of the core where the unwanted lower-order modes (particularly, the fundamental mode) of the signal reside. The reduction (elimination) of the gain medium from these portions of the core minimizes (perhaps to the point of elimination) limits the amount of amplification impressed upon the backward-propagating stokes wave.
|Vibration conduction and frequency-selective amplification device for a moving-iron microphone/transducer|
A vibration conduction and frequency-selective amplification device for a moving-iron microphone/transducer, including connecting portions at both ends and a middle portion for vibration conduction and frequency-selective amplification. The device is mechanically connected to a microphone armature and a vibration diaphragm of the moving-iron microphone/transducer, and performs frequency-selective amplification on a vibration generated by the armature and transmits the vibration onto the diaphragm by the middle portion, so as to achieve frequency-selective amplification and conversion from mechanical energy to acoustic energy.
|Ultra-high power single mode fiber laser system with non-uniformly configure fiber-to-fiber rod multimode amplifier|
A high power fiber laser system includes a booster winch is configured as a fiber amplifier extending over free space, pump source and laser head including a reflective element which receives pump light and reflects toward the output end of the booster in a counter signal-propagating direction. The booster is configured with concentric and coextending frustoconically shaped (“mm”) core and cladding around the core.