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Allergy patents

      

This page is updated frequently with new Allergy-related patent applications.

SALE: 60+ Allergy-related patent PDFs



 Benzazepine sulfonamide compounds patent thumbnailBenzazepine sulfonamide compounds
Wherein r4 or r5 is —so2—nr7r8 and r1 to r8 and y are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are tlr agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases..

 Composition for the prevention and/or treatment of allergy symptoms patent thumbnailComposition for the prevention and/or treatment of allergy symptoms
The present invention relates to a pharmaceutical composition or a food supplement composition and use thereof in the prevention and/or treatment of allergy symptoms, preferably allergic rhinitis and/or allergic conjunctivitis symptoms. In particular, the composition according to the invention comprises at least one slow release component comprising quercetin and at least one fast release component comprising an extract from perilla frutescens or a constituent thereof selected from luteolin, rosmarinic acid, apigenin, catechina, ferulic acid, caffeic acid or mixtures thereof, the invention further comprises the use of the composition in the prevention and/or treatment of allergy symptoms, preferably allergic rhinitis and/or allergic conjunctivitis symptoms..
Ntc S.r.l.


 Nasal stimulation for rhinitis, nasal congestion, and ocular allergies patent thumbnailNasal stimulation for rhinitis, nasal congestion, and ocular allergies
Described here are devices, systems, and methods for treating one or more conditions, such as allergic rhinitis, non-allergic rhinitis, nasal congestion, ocular allergy, and/or symptoms associated with these conditions, by providing stimulation to nasal or sinus tissue. In some variations, the handheld devices may have a stimulator body and a stimulator probe having one or more nasal insertion prongs, and the nasal insertion prongs may be configured to deliver an electrical stimulus to the tissue..
Oculeve, Inc.


 Methods and kits for screening transplant recipients and candidates patent thumbnailMethods and kits for screening transplant recipients and candidates
Methods and kits are provided for determining of immunoglobulin isotypes and subclasses in a subject. In general the subject is a human who is a transplant candidate recipient or recipient, has allergies, or has an autoimmune disease.
National Institute Of Transplantation Foundation


 Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response patent thumbnailImmune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response
The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist.
Idera Pharmaceuticals, Inc.


 Antibody therapeutics that bind ctla4 patent thumbnailAntibody therapeutics that bind ctla4
There is disclosed compositions and methods relating to or derived from anti-ctla4 antibodies. More specifically, there is disclosed fully human antibodies that bind ctla4, ctla4-antibody binding fragments and derivatives of such antibodies, and ctla4-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.


 An anti-cd45rc antibody for use as drug patent thumbnailAn anti-cd45rc antibody for use as drug
The invention relates to an isolated anti-cd45rc antibody for use in preventing or treating transplant rejection, autoimmune diseases, unwanted immune responses against proteins expressed in the course of gene therapy and/or therapeutic proteins, allergy as well as lymphoma or cancer which are associated with cd45rc+ cells. The invention relates to an isolated anti-cd45rc antibody for use in expanding and/or potentiating regulatory t cells..
UniversitÉ De Nantes


 Nanoparticles for treatment of allergy patent thumbnailNanoparticles for treatment of allergy
The present invention encompasses the surprising finding that nanoparticle compositions can have beneficial effects on allergy even when prepared without a known specific allergy therapeutic. The present invention provides such nanoparticle compositions.
Allertein Therapeutics, Llc


 Novel allergen patent thumbnailNovel allergen
The invention relates to a novel horse allergen consisting of a heterodimeric protein having a first peptide chain and a second peptide chain together having an overall sequence identity of at least 70% with the combined sequences of seq id no:3 and seq id no: 4, as well as a single chain protein having an overall sequence identity of at least 70%, such as 75%, 80%, 85%, 90%, 95%, or 98%, with the combined amino acid sequences according to seq id no: 3 and seq id no: 4. The invention further relates to the use of the protein in methods of diagnosis and therapy of type i allergy, and kits and compositions for use in such methods..
Phadia Ab


 Peptides, reagents and methods for detecting food allergy patent thumbnailPeptides, reagents and methods for detecting food allergy
Provided are peptide biomarkers for diagnosis of allergy, monitoring development of clinical tolerance in an allergic individual, and predicting whether an allergic subject is likely to develop clinical or natural tolerance over time. The invention also relates to diagnostic methods and diagnostic kits employing the peptide biomarkers..
Icahn School Of Medicine At Mount Sinai


Nutritional compositions containing dietary butyrate and uses thereof

Provided are nutritional compositions including a component for stimulating butyrate production in the human gut and/or dietary butyrate. Further disclosed are methods of reducing allergic reaction and promoting tolerance to cow's milk allergy in a pediatric subject by providing said nutritional compositions to a target subject..
Mead Johnson Nutrition Company

Application of green tea and its derivatives, composition for use therewith, veterinary pharmaceutical formulation and kit of parts

Use of a composition comprising the administration of crushed leaves of green tea in the treatment of type i allergy. The composition may especially be enriched with substances extracted from green tea, preferably catechin or a derivative thereof.

Allergy-inhibiting sea grape extract, its preparation method and application thereof

Present invention relates to an allergy-inhibiting sea grape extract, its preparation method and thereof. The preparation method includes following steps: the sea grape is blended in distilled water in the weight ratio of 1:1˜20, mix thoroughly, stir at 20-100° c.
East Green Bio Corporation

Prevention or treatment of food allergy in infants and toddlers

The invention pertains to the use of a non-digestible oligosaccharide in the manufacture of a composition for providing nutrition to an infant suffering from an increased risk of food allergy, preferably whey protein allergy; and/or reducing the risk of occurrence of or preventing whey protein allergy in an infant suffering from an increased risk of food allergy, particularly whey protein allergy. The infant is preferably at increased risk of trichothecene mycotoxin exposure, for instance by eating a lot of cereals..
N.v. Nutricia

An isolated interleukin-34 polypeptide for use in preventing transplant rejection and treating autoimmune diseases

The invention relates to an isolated interleukin-34 (il-34) polypeptide for use in preventing or treating graft rejection, autoimmune disease, unwanted immune response against therapeutic proteins and allergy. The invention also provides an in vitro method for determining whether a patient is at risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies, comprising a step of determining the expression level of il-34 in a biological sample obtained from said patient, wherein the presence of il-34 is indicative of a reduced risk of transplant rejection, autoimmune diseases, unwanted immune response against therapeutic proteins or allergies..
UniversitÉ De Nantes

Device and the diagnosis of gastrointestinal allergy

A method and device for the diagnosis of gastrointestinal allergy. The method and the device expose a surface to at least one antigen at a fixed depth.

Dd1alpha receptor and uses thereof in immune disorders

Described herein are methods and compositions for treatment of immune-related diseases or disorders by modulating dd1α activity, alone or in combination with modulation of pd-1 activity. In some embodiments, the methods and compositions described herein are directed to treatment of cancer and/or infections (e.g., bacterial infection, and/or fungal infection).
The General Hospital Corporation

Allergy service management portal

Aspects of the present disclosure involve systems, programs, and methods for an allergy management system (ams). In general, the ams provides a system through which a practitioner or other user may manage allergy-related care for one or more patients.
Allergy Solutions, Inc.

Compositions and methods relating to the treatment of diseases

The present invention relates to compositions and methods for promoting the induction of a cell-mediated immune response (such as that mediated by th1 cells) and the suppression of a humoral or allergic immune response (such as that mediated by th2 and th17 cells). In particular, the invention relates to compositions and methods for preventing or treating allergy, such as food allergy, and associated allergic diseases, and conditions where an exaggerated th17 response plays a detrimental role.
Alfacyte Ltd

Compositions and methods for modulation of rorgammat functions

The present invention relates to expression of rorγt in cells and tissues and the effect of expression of this gene on proliferation of specific immune cells and in promotion of immune cell aggregates and in induction of il17 producing cells. Furthermore, the invention relates to methods and agents that may decrease function of the gene product (the protein) or expression of this gene in individuals experiencing an inflammatory condition, an autoimmune disease or a food allergy, or any other condition whereby it is desirable to inhibit an immune response.

Idr peptide compositions and use thereof for treatment of th2-dysregulated inflammatory conditions

A composition for treating or preventing a th2-dysregulated inflammatory condition wherein the composition comprises a therapeutically effective amount of one or more idr peptides. Use of idr peptides or a composition comprising idr peptides for treating or preventing a th2-dysregulated inflammatory condition.
University Of Manitoba

Synergistic nutritional compositions and uses thereof

Provided are nutritional compositions comprising a combination of a probiotic, dietary butyrate and/or a component for stimulating butyrate production in the human gut. Further disclosed are methods of accelerating tolerance to cow's milk allergy in a pediatric subject by providing said nutritional compositions to a target subject..
Mead Johnson Nutrition Company

Peptide for vaccine

The present invention relates to compositions comprising peptides for preventing or treating allergy to house dust mites, and in particular to optimal combinations of peptides for preventing or treating said allergy.. .
Circassia Limited

Mobile chamber apparatuses and related methods

A mobile chamber apparatus includes a support structure of inflatable support members, and a chamber assembly. The inflatable support members may include transverse and upright sections.
Inflamax Research Inc.

Method for risk assessment of allergic reaction

A method for assessing the risk of an individual developing and immunoglobulin-mediated reaction to one or more allergens increases the specificity of allergy diagnosis and evaluates the specificity of a given allergenic substance. The method may be utilized in in vitro allergy tests, apparatuses, and devices to increase the accuracy and precision of test results.
Excelsior Bio-system Incorporation

Human fgfr2b extracellular domain and nucleic acid for coding same

Provided are wild-type, s252w mutant-type, and p253r mutant-type fgfr2b extracellular segments and truncated proteins thereof, coding genes of the foregoing proteins, a recombinant vector comprising the genes, a host cell, a method for preparing the proteins, and a fusion protein of the proteins and an fc segment. Also provided are applications of the proteins and a composition comprising the proteins in treating eczema, acne, psoriasis, skin allergy, seborrheic dermatitis, or seborrheic alopecia..
Guangzhou Shenglu Biotech Limited Company

Compound of glycosaminoglycan and its fabrication method as well as application

The present invention is related to a compound conjugating a drug with a glycosaminoglycan, such as hyaluronic acid (ha), where the drug is useful for the treatment of diseases such as inflammation, auto-immune disease, allergy, infection and preferably cancer. The conjugated compound of the present invention can increase the concentration of drug at the specific site of disease by an interaction of the glycosaminoglycan used as target drug delivery carrier and the cd44 cell surface receptor, then enhancing the therapeutic efficacy and reducing the systemic side effect of the site-delivered drug..
Holy Stone Healthcare Co., Ltd.

Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist.

Allergy warning and protection system and method

An allergy warning and protection system and method to proactively warn a user and protect a dependent individual, such as a child, suffering from allergies. The system comprises a beacon housed within a wearable, such as a bracelet, that is worn by the dependent.

Humanized anti-ige antibodies that crosslink cd23 on b lymphocytes but do not sensitize mast cells

A novel humanized anti-ige antibody is disclosed. The antibody is capable of binding to free ige, membrane-bound ige on b lymphocytes, ige bound by cd23, but not to ige bound by high-affinity ige.fc receptor on mast cells.
Academia Sinica

Anti-human chemokine (c-c motif) receptor 4 immunotoxins

Anti-human chemokine (c—c motif) receptor 4 immunotoxins and methods of use thereof, e.g., for depleting tregs as an immunotherapy for the treatment of cancer; for the treatment of cancers associated with ccr4+ tumor cells such as skin homing cutaneous t cell lymphoma, adult t cell leukemia/lymphoma, and acute t-cell lymphoblastic leukemia; and for the depletion of cccr4+ th2 cells for the treatment of allergy-related conditions such as asthma.. .
The General Hospital Corporation

Benzimidazole derivatives as pi3 kinase inhibitors

This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries.
Glaxosmithkline Llc

Menu displaying method, menu displaying device

The server receives allergy information. The server controls whether a photograph or an illustration of a product is not displayed in correlation with a name of the product to be displayed on the basis of whether the product includes an allergen corresponding to the allergy information..
Fujitsu Limited

Method of genetically altering and producing allergy free cats

A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, fel d i. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct.

Methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring

Described herein are methods and compositions for treatment of immune-related diseases or disorders and/or therapy monitoring based on the level of tigit, flg2 and/or il-33 expression and/or activity. In some embodiments, the methods and compositions described herein are directed to treatment and/or therapy monitoring of cancer and/or infections (e.g., chronic viral infection, intracellular and/or extracellular bacterial infection, and/or fungal infection).
The Brigham And Women's Hospital, Inc.

Met e 1 tropomyosin variants for use in allergen-specific immunotherapy

The present invention provides isolated met e 1 polypeptides and nucleic acids encoding the isolated polypeptides that can prevent and/or alleviate an allergic response to shellfish tropomyosin. The polypeptides are based on the shrimp tropomyosin met e 1 protein and have been modified to act as hypoallergens.
The Regents Of The University Of California

Device with integrated allergy testing

A coupler for indicating the presence of a substance in blood is disclosed. The coupler includes a housing and a test strip.
Teleflex Medical Incorporated

Dna aptamers specific to cd200r1 and their therapeutic uses

Disclosed are short dna aptamers that selectively recognize cd200r1, a protein expressed on the surface of myeloid and lymphoid cells that delivers immune inhibitory signals to modulate inflammation when engaged with its ligand, cd200. Also disclosed is the use of said aptamers as therapeutic agents, for the purpose of decreasing inflammatory response; treatment of spinal cord injury; treatment of an immune related disease such as arthritis, allergy, infection; as a course of treatment during or after transplantation; or for treatment of an autoimmune disorders such as systemic lupus erythematosus, parkinson's disease, or multiple sclerosis..
D5pharma Inc.

Inhibition of gliadin peptides

Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining modulators of biological barrier permeability and for peptide translocation across biological barriers are provided.
Alba Therapeutics Corporation

Methods and compositions for treating allergy and inflammatory diseases

Described herein are therapeutic approaches with immune modifiers of the th2 pathway for the treatment of allergic and inflammatory diseases. Aspects of the disclosure relate to methods for decreasing th2-type cell responses in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an anti-dectin-1 antibody or antigen binding fragment thereof operatively linked to a tlr agonist..
Baylor Research Institute

Allergen for prophylactic treatment of allergy

A composition comprising at least one first allergen, which is a respiratory allergen belonging to a first biological source material group, for use in prophylactic treatment of allergy to at least one second allergen, which is selected from the group consisting of a respiratory and a venomous allergen belonging to a second biological source material group and a food allergen of a food composition, in a subject, wherein the subject has not developed any clinical symptoms of allergy to the first allergen and to the second allergen, and wherein the first and second biological source material groups are not the same.. .
Alk-abellÓ A/s

Gene delivery stent using titanium oxide thin film coating and fabricating the same

The present invention relates to a gene delivery stent using titanium oxide thin film coating and a method for fabricating the gene delivery stent. The gene delivery stent according to the present invention may be loaded with a drug having anti-inflammatory and anti-thrombotic effects and simultaneously deliver a gene capable of inhibiting proliferation of vascular smooth muscle cells.
Chonnam National University Hospital

Allergy testing device and testing for allergies

An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen.
Lincoln Diagnostics, Inc.

Treatments of ocular allergy with alcaftadine

Compositions, kits and methods for the treatment or prevention of ocular allergies and inflammation and the symptoms thereof comprising alcaftadine or a pharmaceutically acceptable salt thereof.. .
Vistakon Pharmaceuticals, Llc

Allergen exposure system comprising a chamber for mixing air and allergens, which is separated from the exposure room that accommodates the patients

An allergen exposure system includes a mixing chamber, delimited by walls and distinct from the air inlet duct and from the exposure room in which the patients are situated. A mixing between a stream of allergen particles from an allergen injection device and a flow of air devoid of allergens which has passed through a filtration device, occurs through a phenomenon of microturbulence in this mixing chamber which forms a widening with respect to the air inlet duct and makes it possible to obtain a flow of air laden with allergen particles which is injected into the exposure room through at least one diffusion outlet so that it can be inhaled by the patients.
Alyatec

Method for synthesis of a biopolymer derivative, a biopolymer derivative and its use

The invention relates to a method of synthesis of a biopolymer derivative, preferably a chitosan derivative, comprising the formation of a peptide bond. The invention also relates to the biopolymer derivative, and use of the biopolymer derivative, preferably a chitosan derivative.
Instytut Biochemii I Biofizyki Polskiej Akademii Nauk

Treating infection

The present invention relates to surfactant protein d (sp-d) or nucleic acids encoding sp-d or variants thereof such as surfactant protein a or mannan binding lectin for use in the treatment and/or prevention of a parasitic infection. Methods for determining the presence of a parasitic infection by determining levels of sp-d in a sample are also disclosed.
University Of Cape Town

Method of treating inflammation, allergy and asthma with a purified extract (atc1) isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient

The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a ova-sensitized/challenged mouse model..
Korea Research Institute Of Bioscience And Biotechnology

Method of treating inflammation, allergy and asthma with a purified extract (atc2) isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient

The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a ova-sensitized/challenged mouse model..
Korea Research Institute Of Bioscience And Technology

Methods of measuring antigen-specific t cells

Provided herein are methods and kits for assaying antigen-specific t cell responses, such as rare autoantigen-specific t cell responses, by measuring a level of ip-10 in a sample from a subject having or suspected of having an autoimmune disease, an allergy, an infectious disease or condition, or an adverse immune condition caused by administration of an isolated, recombinant or synthetic protein or peptide. Also provided herein are methods and kits for assaying a t cell response to an antigen peptide, such as an islet autoantigen peptide, such as measuring a t cell response to at least one antigen peptide, such as an islet autoantigen peptide, in a sample from a subject, such as one having or suspected of having type 1 diabetes (tid), celiac disease or both..
Immusant, Inc.

Individually customized allergy cream for individual patient profile

A method for delivering an immunomodulator to a patient includes providing a bottle of concentrated immunomodulator extract; progressively diluting the antigen extract in sterile bottles; selecting a prescribed amount from a desired one of the dilution bottles; providing a viscous encapsulation material that is able to introduce antigens contained therein through the skin of a patient; introducing one or more doses of the selected prescribed amount of diluted immunomodulator into the viscous encapsulation material; disposing a prescribed amount of viscous encapsulation material containing the introduced diluted immunomodulator therein within a container that is able to dispense such viscous encapsulation material containing the introduced diluted immunomodulator; dispensing from the container the amount of viscous encapsulation material containing the diluted immunomodulator in an amount equal to a single dose; and applying the dispensed viscous encapsulation material containing the introduced diluted immunomodulator to the skin by the patient or a medical professional.. .
Roca Medical Ltd.

Implantable device for automatic delivery of medication for allergic reactions

Apparatus, implanted subcutaneously or in muscle, fat, joint spaces, or body cavities of any type, detects and responds to an allergic and/or anaphylactic reaction. Detection is carried out by monitoring the levels of biomarker molecules that indicate the occurrence of an allergic and/or anaphylactic reaction, such as: histamine, leukotrienes, prostaglandins, cytokines, tryptase, fc-ε-ri complexes, anaphylatoxin c3a, chymase, carboxypeptidase a, platelet-activating factor8, other mast cell degranulation byproducts, or other basophil activation compounds.

Compositions and methods for treating itching, gingivostomatitis, and demodectic mange

Provided are methods for treating itching caused by allergy, include itching associated with parasite-mediated inflammation (e.g., demodicosis, stomatitis, dermatophytosis, etc.), comprising administration to a mammalian subject in need thereof a therapeutically effective amount of a heat-treated, fractionated thymus extract composition (e.g., thyex-1-6a and -6b compositions, comprising proteins or polypeptides having molecular weights in the range of 3.5 kda to 30 kda), in combination with or formulated with colostrum, to provide for reducing itching in the subject. Combination or adjunctive therapies comprising administration of a heat-treated, fractionated thymus extract composition in combination with or formulated with colostrum, and including at least one additional anti-parasitic, anti-bacterial, anti-fungal, anti-viral agent, or homeopathic agent are also provided.
Cmi Research Management, Llc

Medical software platform

A medical system is disclosed for retrieving and recording information from a patient and generating an efficient and effective clinical report encompassing the relevant data for a practitioner's review. The system may also include one or more communication paths for receiving additional information such as from patient wearables, environmental sensors, medication dispensers, whether sources, allergy sources, and other geographic relevant environmental conditions, contaminants, conditions, traffic congestion, etc..
Victaire Inc.

Nkt cell ligands and methods of use

Alpha-glycosylceramide compounds capable of activating nkt cells and compositions thereof are disclosed. Methods for activating nkt cells, methods of stimulating an immune response in a subject, and methods of treating cancer, infectious diseases, autoimmune diseases and disorders, or allergy diseases or disorders with the compounds and compositions are also disclosed..
Brigham Young Unversity

Purified extract isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma

The present invention relates to inventive novel industrialized method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a ova-sensitized/challenged mouse model..
Korea Research Institute Of Bioscience And Biotechnology

Method for manufacturing fermented food composition

According to a manufacturing method of the present invention, class 2 food allergens can be decomposed even if a protease is not used, and thus a manufacturing cost is inexpensive, and a food composition having a reduced content of class 2 food allergens can be provided without using salt water which has an effect on the taste. The fermented food composition, obtained by the manufacturing method of the present invention, has a sufficiently reduced content of the class 2 food allergens, and thus even those who contracts pollinosis or latex allergy can safely take it.
Kaneka Corporation

Allergy preventing dosage controlled food packets

A kit of individual packets of food containing a dosage amount of an allergen. The kit has a plurality of packets associated with each other and containing a carrier food in each packet and an allergen so arranged that the respective allergen quantity in each successive packet is larger than in the previous packet.

Interleukin-2 for treating food allergy

The present invention relates to the use of interleukin-2 (il-2) for treating a food allergy, either by inducing non-specific tolerance against food allergens, or in a desensitization protocol, in combination with a food allergen.. .
Centre National De La Recherche Scientifique

Compositions and methods for combination ingredient delivery

Described herein are compositions, methods, and devices for relief of a cough, cold, sore throat, or allergy, or a related symptom. Also described herein are compositions, methods, and devices for the prevention, treatment and/or amelioration of a digestive illness or digestive discomfort, or a related symptom of either..
The Fix, Llc

Vaccine comprising amb a 1 peptides for use in the treatment of ragweed allergy

The present invention relates to compositions for preventing or treating allergy to ragweed by tolerisation. The compositions are based on combinations of peptide fragments derived from the major allergen in ragweed pollen, amb a 1.
Circassia Limited

Screening the identification of agents capable of activating cd4+cd25+ regulatory t-cells through interactions with the hiv-1 gp120 binding site on cd4

The present invention relates specific activation of a regulatory t cell via a specific cd4 epitope and uses thereof, e.g. For the treatment of an autoimmune disease or an allergy or asthma or graft rejection or tolerance induction..
Tcf Gmbh

Use of escin

The present invention provides the use of escin for the manufacture of a pharmaceutical preparation for the treatment diseases mediated or caused by activated granulocytes, preferably a type i or type iii allergy or septic shock.. .
Marinomed Biotechnologie Gmbh

Benzazepine dicarboxamide compounds

Wherein r1 to r4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are tlr agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases..

Glycotargeting therapeutics

Several embodiments of the present disclosure relate to glycotargeting therapeutics that are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent. In several embodiments, the compositions are configured to target the liver and deliver antigens to which tolerance is desired.
École Polytechnique Fédérale De Lausanne (epfl)

Allergy skin test devices

An allergy skin test device can include a support strip having a top and bottom face. An allergen can be applied to an area of the bottom face forming an allergen portion.
Rememdia Lc

Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.. .

Novel immunotherapeutic composition and uses thereof

The present invention relates generally to an immunotherapeutic composition. More particularly, the present invention relates to an immunotherapeutic composition which interacts immunologically with t lymphocytes in subjects having peanut allergy or allergy to other tree nuts.
Aravax Pty Ltd

Newly identified peptides for use in the induction of oral tolerance in young mammals

The invention relates to newly identified peptides of that are capable of inducing tolerance to cow's milk, especially to β-lactoglobulin. The peptides may be administered to mammals, especially to young infants who are at risk of allergy to cow's milk proteins, to induce oral tolerance to cow's milk; they may also be administered to children or adults who are allergic to cow's milk to allow “desensitization” towards the allergenic milk proteins, especially β-lactoglobulin, to occur.
Nestec S.a.

C1q as a therapeutic agent of allergy and/or asthma

The present invention concerns c1q for use for treating allergy and/or asthma. The invention also relates to a pharmaceutical composition comprising c1q and at least one allergen and to products comprising c1q and at least one allergen as a combined preparation for use for treating allergy and/or asthma..
Stallergenes

Contact thermo-optical structure and its application for non-invasive imaging of histamine-induced hyperthermal subcutaneous reaction magnitude in cutaneous allergic reaction, recording device and allergic reaction diagnosis

A method of diagnosing allergy according to the invention comprises the steps of stimulation, measurement and comparison. The stimulation step includes at least exposition of a first region of patient's skin to a histamine solution, exposition of a second region of patient's skin to a neutral solution and exposition of a third region of patient's skin to a test substance.

Novel histamine releaser contained in human sweat

Provided are a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.. .
Hiroshima University

Mimotopes for use in immunotherapy for shellfish and/or arthropod allergy

The present invention provides isolated peptides and nucleic acids encoding the isolated peptides that can modify a subject's immune response to tropomyosin. The isolated peptides correspond to peptide epitope mimics that are based on an invertebrate tropomyosin allergen, e.g., the shrimp tropomyosin met e 1.
The Chinese University Of Hong Kong

Effector-deficient anti-cd32a antibodies

Effector-deficient anti-cd32a monoclonal antibodies are encompassed, as are method and uses for treating cd32a-mediated diseases and disorders, including, thrombocytopenia, allergy, hemostatic disorders, immune, inflammatory, and autoimmune disorders.. .
Adventist Health System/sunbelt Inc.

Air purification method and apparatus

An air purification method for use in an apparatus is provided. The air purification method includes: acquiring plant information associated with one or more plants located in a target detection region; determining, based on the plant information and predetermined reference plant information of an allergy-causing plant, that the target detection region contains the allergy-causing plant and the allergy-causing plant is in a blooming state; and in response to the determining, enabling an air purification function of an air purification device..
Xiaomi Inc.

Sirp polypeptide compositions and methods of use

Provided herein are sirp-gamma, sirp-beta or sirp-beta2 decoy polypeptides for immunotherapy and/or treatment of cancer, anemia, transplant, asthma, allergy, auto-immune disease, and viral infection.. .
Ab Initio Biotherapeutics, Inc.

Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor

Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by h4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.. .
Janssen Pharmaceutica Nv

Method and means for diagnosing and treating allergy

Disclosed is a method for diagnosing allergy in a human or animal patient, wherein the level of species-specific lipocalin, especially lipocalin 2 in a human patient, is measured in a sample of said patient and wherein a lowered level of said lipocalin compared to the level of said lipocalin in the corresponding sample of a human or animal that has no allergy, is indicative of an allergy, as well as a kit for performing this method, and a kit for quality control of allergen molecules or extracts used for immunotherapy of allergy by determining its siderophore-iron ligand load and thus immunomodulatory potency. Further, lipocalin proteins for use in treatment or prevention of allergies are provided, preferably complexed with siderophore-iron ligands..
Biomedical International R+d Gmbh

Methods and devices for allergy testing and treatment

A method of testing a patient for allergies includes obtaining from the patient a blood sample having an original volume of at most 0.5 ml, and testing the blood sample for ige reactive with antigens from a plurality of allergen sources by multiple elisa. The blood sample may be taken from the patient in a clinic, and/or the blood sample may be taken by a physician without venipuncture.
Spiriplex, Inc

Method of preventing allergies

The present invention relates to compositions and methods for preventing allergy in a subject. Particularly, the present invention relates to epicutaneous prevention of allergies in children.
Dbv Technologies

Supplement for improving immunotolerance, intestinal environment and intestinal tract barrier

A supplement for improving immunotolerance, intestinal environment and intestinal tract barrier for the purpose of improving intestinal vulnerability, food intolerance or allergy, systemic allergy, autoimmune diseases and systemic inflammatory diseases by immune reactions which is obtained by mixing an ingredient (a) comprising at least one of a probiotic that is any one of lactic acid bacteria, lactobacillus bifidus, saccharified bacteria, natto bacteria and yeast fungus, or a mixture thereof, a biogenic that is a bacteria-producing substance such as lactic acid bacteria, and a prebiotic is indigestible food ingredients such as oligosaccharide, dietary fiber, substance stimulating production of lactobacillus bifidus, and others or a mixture thereof and an ingredient (b) comprising at least one of l-glutamine, zinc, vitamin a and vitamin d.. .

Treatment of celiac disease, c. difficile infection, food intolerance and food allergy with secretory iga/igm

A process is provided for inhibiting symptoms of celiac disease, clostridium difficile associated diseases such as clostridium difficile colitis, pseudomembranous colitis and antibiotic associated diarrhea, food allergy or food intolerance in a subject that includes the oral adminstration to the subject suffering from food allergy or food intolerance an igm. When administered in a, therapeutic quantity based on the subject characteristics and the type of igm, symptoms of food allergy or food intolerance in that subject are inhibited.

Programming of cells for tolerogenic therapies

Biomaterial systems, e.g., gel scaffolds, are used in vivo to recruit immune cells and promote their activation towards a non-inflammatory phenotype, thereby leading suppression of inflammation. The compositions and methods are useful to reduce the severity of autoimmunity, chronic inflammation, allergy, and periodontal disease..
Forsyth Dental Infirmary For Children

Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

The invention provides immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit tlr-mediated signaling in response to a tlr ligand or tlr agonist.
Idera Pharmaceuticals, Inc.

Methods for treating allergic airway inflammation

Provided herein are methods for treating a symptom and/or clinical sign associated with an allergy that includes neutrophil recruitment, such as allergic airway inflammation. In one embodiment, the method includes administering to a subject a composition that includes a cxcr2 inhibitor, a md2 inhibitor, a myd88 inhibitor, or a combination thereof.

Glucopyranosyl lipid a and allergen formulations for sublingual administration

The present application relates to compositions and methods for treating allergy, e.g., peanut allergy, in patients. The methods involve administering glucopyranosyl lipid adjuvant (gla) and peanut allergen(s) to the patient via a sublingual route..
Sanofi

Uses of kappa opioid synthetic peptide amides

The invention relates to methods of use of synthetic peptide amides that are ligands of the kappa opioid receptor in the treatment and prevention of kappa opioid receptor-associated diseases and conditions; and particularly to uses of these agonists in the prophylaxis, inhibition and treatment of pain, inflammation and pruritis associated with a variety of diseases, disorders and conditions. Inflammatory conditions preventable or treatable by the methods of the invention include diseases and conditions associated with elevated levels of a proinflammatory cytokines, such as tnf-α, il-1β, il-6, mmp-1 and mmp-3.
Cara Therapeutics, Inc.

Sirna and their use in methods and compositions for inhibiting the expression of the orai1 gene

The invention relates to si rna molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the orai1 gene. The invention also relates to the use of said si rnas molecules in the treatment and/or prevention of an eye condition characterised by increased expression and/or activity of orai1 gene, preferably said eye condition is conjunctivitis and/or an ocular allergy such as seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, and giant papillary conjunctivitis..
Sylentis Sau

Sirna and their use in methods and compositions for inhibiting the expression of the flap gene

The invention relates to si rna molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the flap gene. The invention also relates to the use of said si rnas molecules in the treatment and/or prevention of an eye condition characterised by increased expression and/or activity of flap gene, preferably said eye condition is conjunctivitis and/or an ocular allergy such as seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, and giant papillary conjunctivitis..
Sylentis Sau

Heat-treated formulation of bifidobacterium lactis ncc 2818 reduces allergic manifestations

Heat treated bifidobacterium lactis ncc 2818 reduces the symptoms of allergies in different groups of patients, such as allergies originating from food allergens in young children, or infants, and food, respiratory and cutaneous allergens in children, adults and household pets. The heat treated bifidobacterium lactis ncc 2818 may be administered alone or in a composition.
Nestec S.a.

Aminotriazolopyridine for use in the treatment of inflammation, and pharmaceutical compositions thereof

The present invention relates to the compound according to formula i, and to its use in medicine, in particular in the treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons. In particular, the compound inhibits jak a family of tyrosine kinases, and more particularly jak1.

Tolerogenic synthetic nanocarriers for allergy therapy

Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and mhc class ii-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.. .
Selecta Biosciences, Inc.

Methods of treating allergies and autoimmune diseases with homogenate of axenic c. elegans

Methods of using axenic c. Elegans homogenate for treating allergies or an autoimmune disease are disclosed.
The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc.

Rnai-mediated inhibition of spleen tyrosine kinase-related inflammatory conditions

Rna interference is provided for inhibition of spleen tyrosine kinase (syk) mrna expression, in particular, for treating patients having a syk-related inflammatory condition or at risk of developing a syk-related inflammatory condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, allergy, or mast-cell disease.. .
Arrowhead Pharmaceuticals, Inc.

Benzazepine dicarboxamide compounds

Wherein r1 to r4 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are tlr agonists and may therefore be useful as medicaments for the treatment of diseases such as cancer, autoimmune diseases, inflammation, sepsis, allergy, asthma, graft rejection, graft-versus-host disease, immunodeficiencies, and infectious diseases..

Compositions and methods for combination ingredient delivery

Described herein are compositions, methods, and devices for relief of a cough, cold, sore throat, or allergy, or a related symptom. Also described herein are compositions, methods, and devices for the prevention, treatment and/or amelioration of a digestive illness or digestive discomfort, or a related symptom of either..
The Fix, Llc

Peptide combinations and uses thereof in treating dust mite allergy

The invention relates to combinations of peptides or variants thereof derived from a portion of an amino sequence of cm a house dust mite allergen, e.g. The allergens der p 1, der f 1, der p 2 and/or der f 2.
La Jolla Institute For Allergy And Immunology

Glycotargeting therapeutics

Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.. .
Ecole Polytechnique Federale De Lausanne (epfl)

Sirna and their use in methods and compositions for inhibiting the expression of the pdk1 gene

The invention relates to sirna molecules and their use in methods and pharmaceutical compositions for inhibiting the expression of the pdk1 gene. The invention also relates to the use of said sirnas molecules in the treatment and/or prevention of an eye condition characterised by increased expression and/or activity of pdk1 gene, preferably said eye condition is conjunctivitis and/or an ocular allergy such as seasonal allergic conjunctivitis, perennial allergic conjunctivitis, vernal keratoconjunctivitis, atopic keratoconjunctivitis, and giant papillary conjunctivitis..
Sylentis Sau

Antibody therapeutics that bind ctla4

There is disclosed compositions and methods relating to or derived from anti-ctla4 antibodies. More specifically, there is disclosed fully human antibodies that bind ctla4, ctla4-antibody binding fragments and derivatives of such antibodies, and ctla4-binding polypeptides comprising such fragments.
Sorrento Therapeutics, Inc.

Amorphous magnesium-substituted calcium phosphate compositions and their uses

Amorphous magnesium-substituted calcium, phosphate compositions and their medical uses are described, in particular for use in delivering cargo materials, such as cargo molecules or cargo nanoparticles contained in pores of the amorphous magnesium-substituted calcium phosphate to cells of the immune system, for example as therapeutic approaches for the treatment of inflammatory bowel diseases, and in particular crohn's disease, autoimmune diseases, allergy and for therapeutic vaccination.. .
Medical Research Council

Method of inducing tolerance to an allergen

The present invention relates generally to the field of allergies. More particularly, the present invention provides a method for treating an allergy in a subject by inducing tolerance to an allergen associated with the allergy.
Murdoch Childrens Research Institute

Toothpaste for delivery of allergens to oral mucosa

Pro-toothpaste compositions formulated to receive a volume of allergen solution to provide toothpastes that exhibit efficacy for oral mucosal immunotherapy (omit) and acceptable consumer and product stability properties, along with kits of pro-toothpaste, allergen/extracts of allergens, and optionally compounding means and/or specialized toothbrushes are provided. Toothpastes suitable and effective for omit and methods for managing allergic symptoms and for reducing risk of allergy in people without symptoms employing the pro-toothpastes, toothpastes and kits of the invention are also disclosed..
Allovate, Llc

Allergy testing tray

An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms.

Method of testing for allergies

An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms.

Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit)

The present invention provides in vitro and in vivo diagnostic tests and methods for determining the safety, efficacy, or outcome of allergen-specific immunotherapy (sit) in a patient. The present invention also provides for the measurement of allergen specific igg and ige in a patient tissue sample, or extract thereof, or in a biological fluid or blood sample, and determining whether the allergen-specific immunoglobulins contained in the patient sample(s), upon injection into an allergen-sensitized animal, will protect the animal following challenge with the allergen.
Regeneron Pharmaceuticals, Inc.

Composition comprising peptide derived from adiponectin

Provided is a pharmaceutical or cosmetic composition comprising adiponectin-derived peptide fragments, i.e., the peptides of seq id nos: 1 to 6 as an active ingredient. The peptides facilitate skin regeneration and moisturization, inhibit skin wrinkle, and have inhibitory activities against allergy and inflammation as well as metastasis of cancer cells..
Supadelixir Inc.

Allergy testing kit

An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms.

Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist.
Idera Pharmaceuticals, Inc.

Human immune therapies using a cd27 agonist alone or in combination with other immune modulators

Methods of inducing t cell proliferation and expansion in vivo for treating conditions wherein antigen-specific t cell immune response are therapeutically desirable such as cancer, infection, inflammation, allergy and autoimmunity and for enhancing the efficacy of vaccines are provided. These methods comprise the administration of at least one cd27 agonist, preferably an agonistic cd27 antibody, alone or in association with another moiety such as immune stimulant or immune modulator such as an anti-cd40, ox-40, 4-1bb, or ctla-4 antibody or an agent that depletes regulatory cells, or a cytokine.
University Of Southampton

Novel compound useful for the treatement of degenerative and inflammatory diseases

A pyrazolopyridine compound according to formula i, able to inhibit jak is disclosed, as well as pharmaceutically acceptable salts, a solvate thereof, solvates of the pharmaceutically acceptable salts and biologically active metabolites thereof. The compound may be prepared as a pharmaceutical composition, and may be used for the treatment or prophylaxis of a variety of conditions in mammals including humans, and particularly, such conditions as may be associated with aberrant jak activity, including by way of non-limiting example, allergy, inflammatory conditions, autoimmune diseases, proliferative diseases, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6..

Phl p 5a derivatives having reduced allergeneity and retained t-cell reactivity

The present invention relates to the preparation and use of variants of the group 5 allergen of the pooideae which are characterised by reduced ige reactivity compared with the known wild-type allergens and at the same time by substantially retained reactivity with t lymphocytes. These hypoallergenic allergen variants can be employed for the specific immunotherapy (hyposensitisation) of patients having grass pollen allergy or for the preventative immunotherapy of grass pollen allergies..
Merck Patent Gmbh

Allergy skin test devices with surrounding pain-reduction structures

An allergy skin testing device is disclosed that includes at least one central post having at least one sharp probe extending longitudinally from an end of the at least one central post, the at least one sharp probe being for administering an allergen to skin. For each central post, at least three dull probes substantially surround the at least one sharp probe, creating a “pain gate fence”, the at least three dull probes being for activating a pain gate effect affecting nerves of the skin while the at leat one sharp probe administers the allergen to the skin.

Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

The invention provides immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit tlr-mediated signaling in response to a tlr ligand or tlr agonist.
Idera Pharmaceuticals, Inc.

A purified extract isolated from pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient, the preparation thereof, and the composition comprising the same as an active ingredient for preventing or treating inflammation, allergy and asthma

A method for preparing purified extract containing more abundant active ingredients such as catalpol derivatives from the extract of pseudolysimachion rotundum var subintegrum than that prepared by the conventional preparation method disclosed in the prior art and the therapeutics or functional health food comprising the purified extract for treating and preventing inflammatory, allergic or asthmatic disease. The purified extract showed more potent anti-inflammatory, anti-allergy and anti-asthma activity than that prepared by the conventional preparation method disclosed in the prior art through various in vivo tests such as inhibition test on the reproduction of eosinophil, the release of immunoglobulin and inflammatory chemokines in plasma and bronchoalveolar fluid as well as the suppression of airway hyperresponsiveness and goblet cell hyperplasia in a ova-sensitized/challenged mouse model..
Korea Research Institute Of Bioscience And Biotechnology

Molecular identification of allergy causing mites by pcr

The present invention relates to novel methods for the identification of specific mite species in a sample, such as mass reared sample or an environmental sample. The invention further relates to nucleic acid molecules encoding the structural ribosomal rna elements (rrna) as well as to the non-functional rna situated between such structural ribosomal rnas of specific mite species and its use for designing primers for use in the method..
Alk-ablló S/a

Composition for use in treating and preventing inflammation related disorder

The present invention is related to a use for treating and preventing inflammation related disorder of a composition containing a drug and hyaluronic acid (ha) or ha mixture, whereas the ha or the ha mixture as a delivery vehicle can be a formulation including at least two has having different average molecular weights. The composition has been demonstrated to be capable of reducing the therapeutic dose of a drug on the treatment and prevention of inflammation related disorders is acute inflammatory disease, chronic obstructed pulmonary disease, coeliac disease, conjunctivitis, otitis, allergic rhinitis, gingivitis, aphthous ulcer, bronchitis, gastroesophageal reflux disease (gerd), esophagitis, gastritis, enteritis, peptic ulcer, inflammatory bowel disease (ibd), crohn's disease, irritable bowel syndrome (ibs), intestinal inflammation or allergy, urethritis, cystitis, vaginitis, proctitis, eosinophilic gastroenteritis, or rheumatoid arthritis..
Aihol Corporation

N-cyanomethylamides as inhibitors of janus kinase

The present invention relates to compounds of general formula (1) that are inhibitors of janus kinase (jak), a family of tyrosine kinases that are involved in inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving impairment of cartilage turnover, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons. In particular, the compound of the invention inhibits jak1 and/or jak2 and/or jak3 sub families.

Method for prognosis of the efficacy of oral immunotherapy for the treatment of allergy to proteins in cow's milk

The present invention relates to a method for prognosis of the efficacy of oral immunotherapy for the treatment of allergy to proteins in cow's milk providing a solution to the problems stated in the state of the art since it provides a method which allows making a prognosis of the number of reactions that will be produced during oral immunotherapy (oit) against proteins in cow's milk and/or an estimate of the treatment time required to achieve tolerance or desensitization during oit against proteins in cow's milk and/or the need for pre-medication during oit in a human subject.. .
Fundación Para La Investigación Biomédica Del Hospital Clinico San Carlos

Regulatory t cell mediator proteins and uses thereof

In particular methods of using these proteins and compounds, preferably antibodies, which bind or modulate (agonize or antagonize) the activity of these proteins, as immune modulators and for the treatment of cancer, autoimmune disease, allergy, infection and inflammatory conditions, e.g. Multiple sclerosis is disclosed.

Anti-allergy benzocycloheptathiophene derivatives

Or a pharmaceutically acceptable salt thereof, solvate, or prodrug thereof, and a pharmaceutically acceptable carrier, vehicle or excipient.. .

Long-term effective patch structure

A long-term effective patch structure includes a binding layer, an absorbing layer and a water-proof layer sequentially stacked together. The binding layer has a function of attaching and fixing, and is configured to be attached and fixed on a skin.
Sigknow Biomedical Corporation Ltd.

Identification of vsig8 as the putative vista receptor (v-r) and use thereof to produce vista/vsig8 agonists and antagonists

The receptor for vista is identified (vsig8) as well as the use of this receptor in the identification or synthesis of agonist or antagonist compounds, preferably antibodies, polypeptides and fusion proteins which agonize or antagonize the effects of vsig8 and/or vista and/or the vsig8/vista binding interaction. These antagonists may be used to suppress vista's suppressive effects on t cell immunity, and more particularly used in the treatment of cancer, or infectious disease.
Immunext, Inc.

Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor

Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by h4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.. .
Janssen Pharmaceutica Nv

Devices, systems and methods of assessing the foundations for the healthy development of an infant or a young child

Devices, systems and methods assess one or more of the risk of an allergy, immediate and/or later in life, for the infant or young child; the risk of an underdeveloped immune system, immediate and/or later in life, for the infant or young child, and/or the immediate risk of a not well-functioning digestive system for the infant or young child, preferably all of these. Optionally, the risk of obesity, immediate and/or later in life, can be additionally assessed.
Nestec S.a.

Pharmaceutical product comprising mite allergen extract(s) and a the manufacture thereof

The invention relates to a pharmaceutical product comprising an allergen extract or an allergoid thereof for the treatment and/or prevention of allergy and allergic asthma caused by house dust mites, which extract comprises at least one extract of mite bodies selected from the following groups a)-b): a) an extract of der p mite bodies, and b) an extract of der f mite bodies, and at least one extract of mite cultures selected from the following groups c)-g): c) an extract of der p faecal particles, d) an extract of der f faecal particles, e) an extract of der f whole mite culture, f) an extract of an der p whole mite culture, and g) a combination of extracts c) to f).. .
Alk-abelló A/s

Preparation of bee venom with allergenic components removed

Disclosed is a method for manufacturing a separated and purified bee venom (separated pbv) not possessing allergy-triggering effects by reducing or eliminating allergy-inducing components contained in a bee venom via ultrafiltration, thereby producing a pvb with desirable pharmacological effects while fundamentally blocking allergies that may be induced by the same. The manufacturing method of the present invention includes a first step of preparing a purified bee venom powder; a second step of preparing a bee venom liquid by mixing the purified bee venom powder with distilled water; a third step of removing allergic ingredients contained in the bee venom liquid via ultrafiltration through a membrane having a cut-off size of 10 kda; and a fourth step of obtaining a separated pbv with the allergenic components removed; wherein the distilled water to be mixed with the purified bee venom powder in the second step is used in the range of from 1000 ml to 1500 ml per 1 g of the purified bee venom powder, the allergenic components removed through the ultrafiltration membrane in the third step are phospholipase a2 and hyaluronidase, and the separated pbv obtained in the fourth step contains 4 wt % or higher of apamin, and 50 wt % or higher of melittin..
Chung Jin Biotech Co., Ltd Hanyang Univ Ansan Campus, Sa-dong

Treatment of food intolerance and food allergy with iga

A process is provided for inhibiting symptoms of food allergy or food intolerance in a subject that includes the oral adminstration to the subject suffering from food allergy or food intolerance an igm. When administered in a therapeutic quantity based on the subject characteristics and the type of igm, symptoms of food allergy or food intolerance in that subject are inhibited.

Effector-deficient anti-cd32a antibodies

Effector-deficient anti-cd32a monoclonal antibodies are encompassed, as are method and uses for treating cd32a-mediated diseases and disorders, including, thrombocytopenia, allergy, hemostatic disorders, immune, inflammatory, and autoimmune disorders.. .
Adventist Health System/sunbelt Inc.

Breathable pillow

An integrated padded mesh material may be used in pillows or pillowcases for improved air flow around a user of the pillow or pillowcase during rest. When used in a pillow, the material may substantially cover the side of the pillow that a user's head rests upon.
Breathablebaby, Llc

Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response

The invention provides novel immune regulatory oligonucleotides (iro) as antagonist of tlrs and methods of use thereof. These iros have unique sequences that inhibit or suppress tlr-mediated signaling in response to a tlr ligand or tlr agonist.
Idera Pharmaceuticals, Inc.

T cell epitopes derived from alt a 1 or alt a 5 for the treatment of alternaria alternata allergy

The application discloses peptides capable of preventing or treating fungal disease, including fungal allergy disease.. .
Alergenetica Sl

Thin planar biological sensor

A thin planar biological sensor is provided, comprising at least one flexible electrode used for contacting a subject's skin and measuring biological signal. The flexible electrode is made of silicon-silver-based material, in which a ratio of silicon to silver-compound is about 7:3.
National Chiao Tung University

Methods and devices for treating primary headache

Non-invasive electrical nerve stimulation devices and magnetic stimulation devices are disclosed, along with methods of treating medical disorders using energy that is delivered noninvasively by such devices. The disorders comprise migraine and other primary headaches such as cluster headaches, including sinus symptoms that resemble an immune-mediated response (“sinus” headaches), irrespective of whether those symptoms arise from an allergy that is co-morbid with the headache.
Electrocore, Llc

Vaccine peptide combinations against cat allergy

The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides. .
Circassia Limited

Recombinantly produced allergens

Methods for producing an allergen composition, methods for in vitro diagnosis of type i allergy, and diagnostic kits for performing diagnosis employ bos d 23k allergen of seq id no: 4, or the mature protein thereof, or a variant or fragment of the bos d 23k allergen or the mature protein sharing epitopes for antibodies with the bos d 23k allergen or the mature protein. Methods for treatment of a type i allergy to a mammal and pharmaceutical compositions employ a bos d 23k allergen of seq id no: 4, or the mature protein thereof, or a variant or fragment of the bos d 23k allergen or the mature protein sharing epitopes for antibodies with the bos d 23k allergen or the mature protein, wherein the bos d 23k allergen, the mature protein, the variant or the fragment is modified to abrogate or attenuate its ige binding response..
Phadia Ab

Beverage compositions and other formulations for treating allergies and methods for making the same

A composition for preventing and/or alleviating an allergy related condition and methods of making such compositions are disclosed herein. A composition in accordance with a particular embodiment can include honey having pollen derived from a known plant species and/or from a known geographic location.

Breathable mattress pad and sleeping accessories

Sleeping accessories such as mattress pads, mattress topper covers, and sheet savers are disclosed herein comprising integrated padded mesh material. Integrated padded mesh material, when used in the sleeping accessories, results in improved air flow for the user, which can reduce complications during sleep such as sudden infant death syndrome.
Breathablebaby, Llc

Anti-il-25 antibodies and uses thereof

The present invention provides antibodies that bind to human interleukin-25 (il-25) and methods of using the same. According to certain embodiments, the antibodies of the invention bind human il-25 with high affinity.
Regeneron Pharmaceuticals, Inc.

Horse allergen and methods

A method for performing in vitro diagnosis of type 1 allergy, comprises contacting an immunoglobulin-containing body fluid sample from a patient suspected of having type 1 allergy with an immobilized horse allergen immobilized on a solid support, and detecting the presence, in the sample, of ige antibodies specifically binding to the horse allergen, wherein the presence of such ige antibodies specifically binding to the horse allergen is indicative of type 1 allergy. A method for treatment of type 1 allergy comprises administering to an individual susceptible to such treatment, the horse allergen, or a form of the horse allergen that is modified to abrogate or attenuate its ige binding response.
Phadia Ab

Rapid allergy testing method

The present invention provides a method for testing an allergy capable of rapidly and highly accurately testing an allergic reaction. The method can determine whether or not a patient has an allergy or whether or not an agent that may be allergenic to a patient has an allergenicity (an allergic reactivity) in the patient.

Refined product obtained from rice hull and preparation process and use thereof

Disclosed herein is a refined product obtained from a rice hull, which consists essentially of a type ii arabinogalactan having a number average molecular weight in the range of 56 to 103 kda. Also disclosed are a process for producing the refined product and use of the refined product for enhancing the biological activity of innate immune cells, as well as for treating allergy and cancer..
China Medical University

Rnai-mediated inhibition of histamine receptor h1-related conditions

Rna interference is provided for inhibition of histamine receptor h1 mrna expression, in particular, for treating patients having an hrh1-related condition or at risk of developing an hrh1-related condition such as allergic conjunctivitis, ocular inflammation, dermatitis, rhinitis, asthma, or allergy.. .
Arrowhead Research Corporation

Novel prostate kallikrein allergen

Methods for treatment of a type i allergy in a mammal comprise administering to an individual in need of such treatment a polypeptide of seq id no: 1 or the mature protein, amino acids 25-260, of the polypeptide of seq id no: 1, or a fragment of the polypeptide or the mature protein, which fragment shares epitopes for antibodies with the polypeptide or the mature protein, respectively, or a hypoallergenic form thereof that is modified to abrogate or attenuate its ige binding response. Diagnostic kits comprise the polypeptide of seq id no: 1 or the mature protein, amino acids 25-260, of the polypeptide of seq id no: 1, immobilized on a solid support..
Phadia Ab

Urine detection inductor suitable for large-scale production

A detector for wet diaper is suitable for large-scale production. The detector comprises a nonwoven fabric (1) and at least two electrodes (2, 3) which are carbon powder coated on the nonwoven fabric (1).

Tolerogenic synthetic nanocarriers for allergy therapy

Disclosed are synthetic nanocarrier compositions, and related methods, comprising immunosuppressants and mhc class ii-restricted epitopes of an allergen that provide tolerogenic immune responses specific to the allergen.. .
Selecta Biosciences, Inc.

A prefilled medication device, making and using the same

The invention generally relates to prefilled disposable medication devices, method of making, and using to store, contain and deliver at least a diluent for allergenic extract and more particularly to a prefilled cartridge containing a diluent for allergenic extract for use with an injection pen for allergy treatments.. .
Phd Preventive Health Care And Diagnostics, Inc.

Glycotargeting therapeutics

Glycotargeting therapeutics are useful in the treatment of transplant rejection, autoimmune disease, food allergy, and immune response against a therapeutic agent.. .
Anokion Sa

Topical ocular preparation of botulinum toxin for use in ocular surface disease

A composition of botulinum toxin is claimed which can penetrate into the ocular surface inclusive of a penetration through a conjunctiva, cornea, and other structures. This composition allows for a maximal penetration of a topical preparation of botulinum toxin which serves to reduce the need for frequent allergy drops for the treatment of ocular surface disease and other conditions causing ocular surface inflammation or deep ocular inflammation.
Botulinum Toxin Research Associates, Inc.

Sprayable oxygenated saline composition and treating nasal congestion, allergy, dryness, eye irritation, throat irritation, wounds, and skin as applied to human tissues

An oxygenated saline composition is provided comprising stabilized oxygen, sodium chloride (aqueous saline solution), and optionally one or more homeopathic components. The stabilized oxygen can include quad-atomic oxygen.
Oxy Bump Corporation

Novel high throughput assay for finding new jak3 interacting compounds, biomolecules, and inhibitors.

Janus kinase 3 is a non-receptor tyrosine kinase that mediates signals initiated by cytokines through interactions with the receptors of cytokines. Abnormal activation of jak3 was associated with human hematologic and epithelial malignancies.

Method of genetically altering and producing allergy free cats

A transgenic cat with a phenotype characterized by the substantial absence of the major cat allergen, fel d i. The phenotype is conferred in the transgenic cat by disrupting the coding sequence of the target gene with a specialized construct.

System and multiple allergen testing

The testing apparatus includes a capsule 108 tray and a hand held allergen applicator 104 that facilitates convenient storage and easy application of such allergens simultaneously. The hand held applicator 104 includes a plurality of prongs to administer the respective plurality allergen under the skin of the patient.

Peptide carrier fusion proteins as allergy vaccines

The present invention relates to a polypeptide comprising at least three peptide fragments consisting of 10 to 50 consecutive amino acid residues of at least one wild-type allergen fused to the n- and c-terminus of a surface polypeptide of a virus of the hepadnaviridae family or at least one fragment of said surface polypeptide.. .
Biomay Ag

Design of oligonucleotide analogs as therapeutic agents

It is believed that the compounds and compositions as described herein have therapeutic utility against a variety of diseases, including viral diseases, autoimmune diseases (such as, allergy, asthma, and inflammatory disorders) and cancer.. .

Igy composition for use in celiac disease

The present invention relates to an igy composition characterized in that said igy composition contains igy antibodies, fragments, and/or fab fragments thereof that specifically bind to a peptide with the amino acid sequence of seq id no: 1 and to the use of this igy composition in the therapy of celiac disease, rheumatism, and/or wheat allergy.. .
Charite - Universitatsmedizin Berlin

Novel immunotherapeutic molecules and uses thereof

The present invention relates generally to molecules such as peptides, polypeptides and proteins which interact immunologically with t lymphocytes in subjects having peanut allergy, or allergy to other tree nuts, and genetic sequences encoding same. These molecules are preferably immunointeractive with t cells in subjects having an allergy to the ara h 1 allergen.
Health, Alfred

Animal food composition and process for production

An animal food composition comprising a protein source and corn starch, wherein native high-amylose corn starch comprises at least 50% of the corn starch. The composition can be used to treat or prevent a food allergy in an animal.
Hill's Pet Nutrition, Inc.

Process for producing an allergen extract

The present invention discloses processes for producing native, depigmented and polymerised allergen extracts. The invention further discloses extracts produced via the processes, and pharmaceutical and vaccine compositions comprising the extracts, for diagnosis and treatment of allergy..
Laboratorios Leti, S.l.

Methods of treating or preventing respiratory conditions

The present disclosure provides methods of treating or preventing respiratory condition and/or for treating an ige-mediated allergy and/or for reducing an allergic response to an allergen and/or for inducing anergy to an allergen in a subject and/or improving lung function in a subject suffering from an allergy comprising administering to a subject a population of cells enriched for stro-1+ cells and/or progeny thereof and/or soluble factors derived therefrom.. .
Mesoblast, Inc.

New fusion proteins for the treatment of allergic diseases

The present invention relates to a fusion protein comprising a first peptide and a second peptide linked together with a linker, wherein the first peptide is an allergen and the second peptide is a targeting unit and the targeting unit is a fgl-2 c-terminal peptide according to seq id no 1. Provided herein are also uses of said fusion protein as a vaccine for treating allergy, such as shrimp, peanut or mite allergy, as well as a vaccine composition and methods for producing such fusion proteins..
Veteriaerinstituttet

Bifidobacterium for dust mite allergy

A composition comprising bifidobacterium breve for use in improving lung function in human subjects suffering from dust mite allergy.. .
N.v. Nutricia

Allergy treatment using acid treated aqueous whey protein extract

The invention relates to manufacture of whey protein extracts, to infant formula and to reducing or preventing food allergy. The whey protein extract is produced from a whey protein-containing composition by contacting a whey protein-containing composition with an aqueous solution to form a sample including a soluble protein-containing component and an insoluble component; recovering the soluble protein-containing component from the sample; and acidifying the soluble protein-containing component, thereby producing the whey protein extract.
Women's And Children's Health Research Institute

System and automatic reading of an allergy

A system and method for automatic reading skin for an allergy to a substance, includes a consumer electronics device that acquires images of skin; a consumable member having a surface divided into elementary areas, each elementary area with a different possible allergenic substance; and a palette that, when applied against each elementary area brings the depositing part into contact with the skin thereby depositing the corresponding possible allergenic substance on or under the skin, where an image processing operation of the image of the skin taken by the consumer electronics device localizes the location that each depositing part has deposited the possible allergenic substance during the application and provides information in relation with a sensitivity of the skin, as indicated by a visible reaction, to the possible allergenic substance at each localized location.. .
Ergylink

Allergy skin test applicator, and related testing tray, testing kit and testing method

An allergy testing kit contains a plurality of allergy testing applicators, an allergy testing tray and a plurality of allergen bottles each containing an allergen. Each of the applicators contains an elongated handle, a plurality of arms extending from the elongated handle and disposed in an asymmetrical configuration, and a plurality of legs with tines extending from each of the arms.

Wheat proteomic microarray for biomarker discovery

This invention pertains to the preparation of arrays containing the proteome of wheat, including gluten and non-gluten proteins. Antibodies to wheat gluten have been shown to be elevated, not only in celiac disease and wheat allergy, but also in neuropsychiatric disorders, such as schizophrenia, bipolar disorder, and autism.
The Trustees Of Columbia University In The City Of New York

M cells and artificial skin sheet

[problem] to provide m cells having excellent strength and anti-allergy activity and an artificial skin sheet formed from the m cells. [solution] gp2 contained in the m cells is transferred to the intracellular tight junction and galectin 9 is expressed in the m cells.

Plastic blood lancet

The present invention provides a surgically invasive pointed article for skin penetration and capillary whole blood extraction whose penetration ability can be disabled after use by deforming the tips. The present invention is made by injection moulding a plastic needle 35 having an anchoring means 45 using a first material, followed by another injection moulding process to over-mould a first body segment 20 and second body segment 30 using a second material to encase the plastic needle 35 thereby anchoring the plastic needle 35 to prevent further movement of the plastic needle 35.

Compositions for immunotherapy

The present invention relates to compositions which can be used in immunotherapy and especially to compositions which can be used in immunotherapy for mammals suffering from a peanut allergy. The present invention further relates to the use of the present compositions for the treatment of a mammal suffering from an allergy by immunotherapy and the use of the present compositions in a prophylactic treatment for desentizing the immune system of a mammal for an allergen.
Hal Allergy Holding B.v.

Nutritional compositions containing ceramide and uses thereof

The present disclosure relates to nutritional compositions that include at least one ceramide. The nutritional compositions may further include galactose, sialic acid, or cholesterol.
Mead Johnson Nutrition Company

Benzimidazole derivatives as pi3 kinase inhibitors

This invention relates to the use of benzimidazole derivatives for the modulation, notably the inhibition of the activity or function of the phosphoinositide 3′ oh kinase family (hereinafter pi3 kinases), suitably, pi3kα, pi3kδ, pi3kβ, and/or pi3kγ. Suitably, the present invention relates to the use of benzimidazoles in the treatment of one or more disease states selected from: autoimmune disorders, inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, allergy, asthma, pancreatitis, multiorgan failure, kidney diseases, platelet aggregation, cancer, sperm motility, transplantation rejection, graft rejection and lung injuries.
Glaxosmithkline Llc

Substituted fused tricyclic compounds, compositions, and medicinal applications thereof

The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by jak activity. Such conditions include, but not limited to, arthritis, alzheimer's disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, t-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, t-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or type i diabetes, complications from diabetes, rheumatoid arthritis, asthma, crohn's disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis.

Novel histamine releaser contained in human sweat

Provided arc a sweat allergy antigen, an antibody capable of binding to the antigen specifically, and others, which are produced utilizing a microorganism-originated protein that exists in sweat allergy patient in a dissolved state or a partial peptide of the protein.. .
Hiroshima University

Use of anti-cd1 antibodies for the modulation of immune responses

The invention provides methods for the administration of an anti-cd1 antibody for the treatment or prevention of a variety of disorders, such as autoimmune disease, viral infection, bacterial infection, parasitic infection, infection by a eukaryotic pathogen, allergy, asthma, inflammatory condition, graft versus host disease, graft rejection, immunodeficiency disease, spontaneous abortion, pregnancy, and cancer.. .
Beth Israel Deaconess Medical Center, Inc.

Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders

Useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.. .

Pharmaceutical compositions for the treatment of inflammatory disorders

Useful in the prophylaxis and/or treatment of inflammatory conditions, autoimmune diseases, proliferative diseases, allergy, transplant rejection, diseases involving degradation and/or disruption of cartilage homeostasis, congenital cartilage malformations, and/or diseases associated with hypersecretion of il6 or interferons.. .

Probiotics for use in reducing eosinophilia and respiratory allergies

The present invention provides probiotic compositions suitable for reducing the incidence and duration of nasal eosinophilia and other parameters associated with birch pollen allergy. In some embodiments, the present invention provides methods and/or compositions suitable for reducing nasal and/or respiratory allergy symptoms..
Dupont Nutrition Biosciences Aps

Compositions and methods for modulation of rorgammat functions

The present invention relates to expression of rorγt in cells and tissues and the effect of expression of this gene on proliferation of specific immune cells and in promotion of immune cell aggregates and in induction of il17 producing cells. Furthermore, the invention relates to methods and agents that may decrease function of the gene product (the protein) or expression of this gene in individuals experiencing an inflammatory condition, an autoimmune disease or a food allergy, or any other condition whereby it is desirable to inhibit an immune response.

Cladosporium peptides

Polypeptides which may be used for preventing or treating allergy to moulds of the cladosporium and/or alternaria genus, have up to 30 amino acids in length and comprise: (i) the amino acid sequence: (a) ggykaavrptmle (seq id no: 35; cla35), (b) ae v yqklk sltkk (seq id no: 31; cla16), (c) vaityasraqgae (seq id no: 32; cla25), (d) ghhfkergt-gslvit (seq id no: 33; cla26), or (e) anytqtktvsirl (seq id no: 34; cla29); or (ii) a t cell epitope-containing variant sequence which is a said amino acid sequence (i) having up to six amino acid modifications, each of which is independently a deletion, substitution or insertion.. .
Circassia Limited

Allergy testing device and testing for allergies

An allergy testing system comprises a skin test device having a grip portion for holding the device. One or more legs extend from the grip, and each leg is oriented to interact with a well containing a potential allergen.
Lincoln Diagnostics, Inc.

Monoclonal lge antibody that binds to sweat allergy antigen protein

Provided include a human ige antibody that binds to a sweat allergy antigen protein and a human high-affinity ige receptor but does not induce degranulation in a reaction with the sweat allergy antigen protein, and a composition for treatment or diagnosis of sweat allergy comprising the same.. .
Hiroshima University

Novel allergen from ragweed pollen and uses thereof

The present invention notably concerns a novel major allergen from ragweed pollen, named amb a x, as well as isoallergens and isoforms thereof. Fragments of the aforementioned polypeptides and homologous polypeptides, in particular homologous polypeptides in related plant species, also make part of the invention.
Stallergenes S.a.

Compositions and methods relating to the treatment of diseases

A method is provided for the treatment and/or prophylaxis of a condition where an enhancement of a th1-mediated immune response and suppression of a th2/th17-mediated immune response are desired. The method comprises the step of administering to a subject in need thereof a therapeutically effective amount of at least one interferon alpha subtype selected from ifn-α10, ifn-α14, and a hybrid thereof.
Alfacyte, Ltd.

Inhibition of gliadin peptides

Novel compounds and methods for the inhibition of biological barrier permeability and for the inhibition of peptide translocation across biological barriers are identified. Assays for determining modulators of biological barrier permeability and for peptide translocation across biological barriers are provided.
Alba Therapeutics Corporation

Peptides for vaccine against birch allergy

The present invention relates to compositions comprising peptides for preventing or treating allergy to birch, and in particular to optimal combinations of peptides for preventing or treating said allergy.. .
Circassia Limited

Hypo-allergenic cross-linked proteins for use in the prevention of an allergy against milk-proteins and for use in the induction of oral tolerance

The present invention provides a hypo-allergenic cross-linked protein for use in the prevention of an allergy against milk proteins, or for use in the induction of oral tolerance for milk proteins, said cross-linked protein being selected from cross-linked casein, cross-linked caseinate and combinations thereof. The invention further provides a nutritional composition for use in the prevention of an allergy against milk proteins or for use in the induction of oral tolerance against milk proteins..
Friesland Brands B.v.

Treatment of lge-mediated disease

The methods and compositions described herein are based, in part, on the discovery of a polypeptide of soluble cd23 (scd23) that binds and sequesters ige. Thus, the scd23 peptides, polypeptides and derivatives described herein are useful for treating conditions or disorders involving increased ige levels such as e.g., allergy, anaphylaxis, inflammation, lymphoma, and certain cancers..
Trustees Of Boston University

Alpha-enolase specific antibodies and use in immune diseases

A method for treating an inflammatory disease or an immune disorder includes administering to a subject in need of such treatment an antagonist against eno1. The antagonist binds eno1 and inhibits eno1 plasminogen receptor activity.
Development Center For Biotechnology

Nanoparticles for treatment of allergy

The present invention encompasses the surprising finding that nanoparticle compositions can have beneficial effects on allergy even when prepared without a known specific allergy therapeutic. The present invention provides such nanoparticle compositions.
Allertein Therapeutics, Llc

Novel pyridopyrimidine derivatives and use thereof

The invention provides novel substituted pyridopyrimidines represented by formula i or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of the phosphoinositide 3′ oh kinase family (pi3k) for the treatment of inflammatory diseases, cancer, cardiovascular diseases, allergy, asthma and autoimmune disorders..
Cmg Pharmaceutical Co., Ltd.

Materials and methods for diagnosing and treating shellfish allergy

The disclosure provides materials and methods for diagnosing, treating and preventing shellfish allergic reactions, including allergic reactions to shrimp. The technology involves one or more shellfish-specific proteins selected from the group of myosin light chain, sarcoplasmic calcium-binding protein, hemocyanin, fatty acid binding protein, and troponin c, for example from shrimp, as well as encoding polynucleotides, vectors host cells, and specific binding partners for such proteins, e.g., antibodies.
Icahn School Of Medicine At Mount Sinai

Hypoallergenic hybrid proteins of major group 1 and 2 mite allergens for use in the treatment of allergies

The present invention refers to recombinant and molecules coding to hybrids polypeptides of different allergens from d. Pteronyssinus useful for the prevention and treatment of allergies, particularly allergies caused by mites.
Bial Industrial Farmaceutica, S.a.

Uses of kappa opioid synthetic peptide amides

The invention relates to methods of use of synthetic peptide amides that are ligands of the kappa opioid receptor in the treatment and prevention of kappa opioid receptor-associated diseases and conditions; and particularly to uses of these agonists in the prophylaxis, inhibition and treatment of pain, inflammation and pruritis associated with a variety of diseases, disorders and conditions. Inflammatory conditions preventable or treatable by the methods of the invention include diseases and conditions associated with elevated levels of a proinflammatory cytokines, such as tnf-α, il-1β, il-6, mmp-1 and mmp-3.
Cara Therapeutics, Inc.

Composite with antibacterial and antipruritic functions

A composite with antibacterial and antipruritic functions includes a first substrate extracted from a plant, a second substrate and a base, and the first substrate includes a loniceraiaponica extract and an acanthopanax extract, and both loniceraiaponica extract and acanthopanax extract have a weight percentage ranging from 0.75 to 1.33, and the composite can effectively restrain the itch caused by skin pustules, folliculitis, and mosquito bites, and achieve the moisturization and antipruritic and anti-dander effects for mitigating the symptoms caused by candida albicans and staphylococcus aureus. In addition, this composite has good effects on general skin diseases such as hand eczema (ktpp), eczema, and lip herpes.
Li Tzu Pao Mei Regiman Beauty Public Ltd. Company

Wound healing composite with a function of promoting the growth of granulation tissues

A composite with antibacterial and antipruritic functions includes a first substrate extracted from a plant, a second substrate and a base, and the first substrate includes a loniceraiaponica extract and an acanthopanax extract, and both loniceraiaponica extract and acanthopanax extract have a weight percentage ranging from 0.75 to 1.33, and the composite can effectively restrain the itch caused by skin pustules, folliculitis, and mosquito bites, and achieve the moisturization and antipruritic and anti-dander effects for mitigating the symptoms caused by candida albicans and staphylococcus aureus. In addition, this composite has good effects on general skin diseases such as hand eczema (ktpp), eczema, and lip herpes.
Li Tzu Pao Mei Regiman Beauty Public Ltd. Company

Wound healing composite with a function of promoting the growth of granulation tissues

A wound healing composite with a function of promoting the growth of granulation tissues includes a substrate extracted from a plant and a base, and the substrate includes a loniceraiaponica extract, a mugwort extract, and ginkgo, and both loniceraiaponica extract and ginkgo have a weight percentage ranging from 0.28% to 3.5%. The wound healing composite can effectively promote the growth of granulation tissues, and loniceraiaponica, mugwort, ginkgo and other ingredients are extracts of natural plants, and thus the wound healing composite has a low drug resistance and does not have the side effect of drug allergy or the doubt leading to skin cancer..
Li Tzu Pao Mei Regiman Beauty Public Ltd. Company

Playdate scheduling system

A social scheduling system includes member profile information. Each member profile includes information about a member and one or more of the member's associated entities.

Benzoimidazol-2-yl pyrimidines and pyrazines as modulators of the histamine h4 receptor

Benzoimidazol-2-yl pyrimidines and pyrazines, pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by h4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritis.. .
Janssen Pharmaceutica Nv

Formulation of dual cycloxygenase (cox) and lipoxygenase (lox) inhibitors for mammal skin care

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—free-b-ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with the skin. This composition of matter simultaneously inhibits cyclooxygenase (cox) and lipoxygenase (lox) enzymatic activity in normal, aged and damaged dermal cells and tissues.
Unigen, Inc.

Combined allergy treatment and anti-drying compositions and related methods

Compositions and methods for alleviating an allergy condition while also reducing a drying effect of an allergy treatment composition or another anti-mucosal composition. In some embodiments and implementations, a composition may be provided comprising an allergy treatment composition comprising an antihistamine in a therapeutically effective amount for treating the allergy condition in the human having the allergy condition.
Xlear, Inc.

Use of wf10 for treating allergic asthma, allergic rhinitis and atopic dermatitis

The present invention provides a method of treating or inhibiting at least one of allergic asthma, allergic rhinitis and atopic dermatitis, or of reducing, inhibiting or treating allergy like symptoms. The methods use compositions comprising chlorite, chloride, chlorate and/or sulfate ions..
Nuvo Research Ag

Compositions and methods for the treatment of cough

The invention relates to the compounds of formula i or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i, and methods for treating or preventing cough may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.

Fully self-contained unit dose devices for allergy skin testing

The present invention discloses a system for applying antigens or other diagnostic substances to the skin of a subject for allergy testing. The system is comprised of fully contained predetermined quantities of antigenic or other testing material contained in sealed unit doses that maintain sterility and provide for precise handling and administration.
Mystic Pharmaceuticals, Inc.

Compositions and methods for the treatment of asthma and allergy

The invention relates to the compounds of formula i or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula i, and methods for the treatment of asthma and allergy may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection.

Plant profilin polypeptides for use in non-specific allergy immunotherapy

The invention relates to the treatment of a hypersensitivity immune response caused by a non-profilin allergen of a profilin-containing plant material (e.g. Grass or tree pollen) by bystander suppression with a plant profilin (e.g.
Alk-abello A/s



Allergy topics:
  • Autoimmune
  • Prophylactic
  • Ophthalmic
  • Autoimmune Disorder
  • Immune Disorder
  • Dermatitis
  • Staurosporin
  • Aspergillosis
  • Angioedema
  • Allergic Rhinitis
  • Food Allergy
  • Therapeutical
  • Bronchopulmonary
  • Staurosporine
  • Sudden Infant Death


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