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Alkyne patents

      

This page is updated frequently with new Alkyne-related patent applications.




 Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via new patent Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via "click" chemistry
This invention relates to a 2′-modified rna agent comprising at least one rna strand containing a 2′-o substituent having an alkyne functional group attaching to the o atom at the 2′-position on one or more ribose rings, wherein the 2′-o substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the rna strand. This invention also relates to a 2′-modified rna agent comprising at least one rna strand containing a 2′-o substituent having a triazole functional group attaching to the o atom at the 2′-position on one or more ribose rings, wherein the 2′-o substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the rna strand..
Sirna Therapeutics, Inc.


 Alkenes as alkyne equivalents in radical cascades terminated by fragmentations patent thumbnailnew patent Alkenes as alkyne equivalents in radical cascades terminated by fragmentations
Disclosed are methods for rerouting radical cascade cyclizations by using alkenes as alkyne equivalents. The reaction sequence is initiated by a novel 1,2 stannyl shift which achieves chemo- and regioselectivity in the process.
The Florida State University Research Foundation, Inc.


 Photochromic compounds patent thumbnailPhotochromic compounds
A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent q attached thereto, each q independently being —n3, —cn, —coor′, —ccr′, —c(r′)c(r′)r′, —ocor′, —ocoor′, —sr′, —oso2r′″, and/or —con(r′)r′, wherein each r′ is hydrogen, an unsubstituted or substituted alkyl group having from 1 to 18 carbon atoms; an unsubstituted or substituted aryl group, an unsubstituted or substituted alkene or alkyne group having from 2 to 18 carbon atoms, wherein the substituents are halo or hydroxyl and r′″ is —cf3 or a perfluorinated alkyl group having from 2 to 18 carbon atoms the number, locations and nature of the constituents q are dependent upon the structure of the photochromic compound..
Transitions Optical, Inc.


 Photochromic comounds patent thumbnailPhotochromic comounds
A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent q attached thereto, each q independently being —n3, —cn, —coor′, —ccr′, —c(r′)c(r′)r′, —ocor′, —ocoor′, —sr′, —oso2r′″, and/or —con(r′)r′, wherein each r′ is hydrogen, an unsubstituted or substituted alkyl group having from 1 to 18 carbon atoms; an unsubstituted or substituted aryl group, an unsubstituted or substituted alkene or alkyne group having from 2 to 18 carbon atoms, wherein the substituents are halo or hydroxyl and r′″ is —cf3 or a perfluorinated alkyl group having from 2 to 18 carbon atoms the number, locations and nature of the constituents q are dependent upon the structure of the photochromic compound..
Transitions Optical, Inc.


 Nucleic acid coated colloids patent thumbnailNucleic acid coated colloids
Dna-coated colloids are introduced that can rearrange and anneal using single-stranded dna coatings with thicknesses that are smaller than the colloidal particles, and with areal densities 5—than previously achieved. Micrometer-sized colloidal particles, such as poly(styrene), poly(methylmethacrylate) (pmma), silica and titania, and 3-(trimethoxysilyl)propyl methacrylate (tpm), are coated with dna by strain-promoted alkyne-azide cycloaddition.
New York University


 Clickable waterborne polymers and click-crosslinked waterborne polymers, clickable functional compounds, click functionalized waterborne polymers, and uses thereof patent thumbnailClickable waterborne polymers and click-crosslinked waterborne polymers, clickable functional compounds, click functionalized waterborne polymers, and uses thereof
Clickable waterborne polymers, click crosslinking of waterborne polymers, click crosslinked waterborne polymers, clickable functional compounds, and click functionalized waterborne polymers are presented. For example, the waterborne polymers have pendant groups bearing alkyne and/or azide groups and alkyne.
The Penn State Research Foundation


 Disulfide-containing alkyne linking agents patent thumbnailDisulfide-containing alkyne linking agents
Described are improved disulfide-containing alkyne linking agents having have branched disulfides. The improved linking agents exhibit improved stability.
Arrowhead Madison Inc.


 Novel reagents for universal site-specific labeling and modifications of nucleic acids patent thumbnailNovel reagents for universal site-specific labeling and modifications of nucleic acids
The present invention discloses a method of harnessing versatile phosphoramidation reactions to regioselectively incorporate alkynyl/azido groups into post-synthetic nucleic acids primed with phosphate at the 5′ termini. With and without the presence of copper, the modified nucleic acids were subjected to azide-alkyne cycloaddition to obtain various nucleic acid conjugates including a peptide-oligonucleotide conjugate (poc) with a high yield..
Kaohsiung Medical University


 Methods of producing dicarbonyl compounds patent thumbnailMethods of producing dicarbonyl compounds
Dicarboxylic acids, such as adipic acid, and diesters, such as adipates, may be produced by hydrogenating alkynes that may be produced from raw materials salvaged from waste stream processes. The carbons of the dicarboxylic acids are provided by alkynes generated from biomass waste and carbon dioxide recovered from waste streams such as exhaust gases..
Empire Technology Development Llc


 Process for the ruthenium catalyzed trans-selective hydrostannation of alkynes patent thumbnailProcess for the ruthenium catalyzed trans-selective hydrostannation of alkynes
The present invention refers to a process for the ruthenium-catalyzed trans-selective hydrostannation of alkynes and the so-obtained products. The inventive process makes use of a tin hydride which is reacted with an alkyne in the presence of a cyclopentadienyl-coordinated ruthenium catalyst..
Studiengesellschaft Kohle Mbh


Process for the trans-selective hydroboration of internal alkynes

The present invention refers to a process for the trans-selective hydroboration of internal alkynes and the so-obtained products. The inventive process makes use of a borane of the formula x1x2bh selected from the group of dialkyl boranes or di(alkoxy)boranes which are reacted with the internal alkynes in the presence of a cyclyopentadienyl-coordinated ruthenium catalyst..
Studiengesellschaft Kohle Mbh

Compositions and methods for modification of biomolecules

The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions.
The Regents Of The University Of California

Methods for post-fabrication functionalization of poly(ester ureas)

Amino acid-based poly(ester urea)s (peu) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of peus carrying pendent “clickable” groups on modified tyrosine amino acids.
The University Of Akron

Bicyclic alkyne derivatives and uses thereof

The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the map kinase interacting kinases mnk2a, mnk2b, mnk1a, and mnk1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases, and neurodegenerative diseases (e.g.
Agency For Science, Technology And Research

Method for producing asymmetric conjugated diyne compound and producing z,z-conjugated diene compound using the same

Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride and a method for producing a z,z-conjugated diene compound from the asymmetric conjugated diyne compound thus obtained. More specifically, provided is a method for producing an asymmetric conjugated diyne compound comprising a step of subjecting a terminal alkyne compound (1): hc≡c—z1—y1 to a coupling reaction with an alkynyl halide (2) y2—z2—c≡c—x by using sodium borohydride in water and an organic solvent in the presence of a copper catalyst and a base to obtain the asymmetric conjugated diyne compound (3): y2—z2—c≡c—c≡c—z1—y1.
Shin-etsu Chemical Co., Ltd.

Amine precursors for depositing graphene

The present invention relates to the use of an amine precursor of formula i (x1—r1)n—nh(3-n) (i) or its ammonium salts for depositing a graphene film having a nitrogen content of from 0 to 65% by weight on a substrate s1 by chemical vapor deposition (cvd), wherein r1 is selected from (a) c1 to c10 alkanediyl, which may all optionally be interrupted by at least one of o, nh and nr2, (b) alkenediyl, which may all optionally be interrupted by at least one of o, nh and nr2, (c) alkynediyl, which may all optionally be interrupted by at least one of o, nh and nr2, (d) c6 to c20 aromatic divalent moiety, and (e) co and ch2co, x1 is selected from h, oh, or2, nh2, nhr2, or nr22, wherein two groups x1 may together form a bivalent group x2 being selected from a chemical bond, o, nh, or nr2, r2 is selected from c1 to c10 alkyl and a c6 to c20 aromatic moiety which may optionally be substituted by one or more substituents x1, n is 1, 2, or 3.. .
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.

Ink compositions comprising surfactants having limited solubility

Disclosed herein are ink compositions comprising a self-dispersed pigment in a liquid vehicle. The liquid vehicle can comprise a solvent/water mixture in which the composition further comprises a surfactant system having limited solubility/compatibility with the liquid vehicle.
Cabot Corporation

Inorganic filler, resin composition comprising the same and heat radiation substrate using the same

An inorganic filler according to an embodiment of the present invention includes a boron nitride agglomerate and a coating layer formed on the boron nitride agglomerate and including a —si—r—nh2 group, and r is selected from the group consisting of an alkyl group having 1 to 3 carbon atoms, an alkene group having 2 to 3 carbon atoms, and an alkyne group having 2 to 3 carbon atoms.. .
Lg Innotek Co., Ltd.

Lignin-containing polymers

Click reactions may be used to bond polymers to lignin by taking advantage of lignin's terminal hydroxyl and thiol groups via an alkyne-azide click reaction or a thiol-alkene or thiol-alkyne click reaction. By selecting functional polymers, these methods may be used to synthesize lignin-containing polymer materials with an array of different properties, such as self-healing polymers..
Florida State University Research Foundation, Inc.

Catalysed ligation of azides and acetylenes

A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting a solution of an organic azide and a terminal alkyne with a source of catalytic ru ion to form a 1,4-disubstituted 1,2,3-triazole..
The Scripps Research Institute

Hydrogenation reactor and process

A reactor and process for removing unsaturated alkynes and diolefinic impurities from olefins and oxygenates is described.. .
Saudi Basic Industries Corporation

Phosphorus-containing catalysts

The invention provides compounds of general structure i: (ar1—ar2—ar3-e-p(=d)r2-)nmmxnln″. In this structure: •ar1, ar2 and ar3 are aromatic groups wherein: —ar1 and ar3 are in a 1,3 relationship on ar2, —each of ar1, ar2 and ar3 optionally comprises one or more ring substituents of formula yr′r wherein each y independently is absent or is o, s, b, n or si and each r′ is independently h, halogen, alkyl, cycloalkyl, aryl or heteroaryl and r is 1, 2 or 3, where r is 1 if y is absent or is o or s, 2 if y is b or n and 3 if y is si, —ar1, ar2 and ar3 are each independently carbocyclic or heterocyclic and each is independently monocyclic, bicyclic or polycyclic and each ring of each of ar1, ar2 and ar3 independently has 5, 6 or 7 ring atoms; •e is absent or is selected from the group consisting of o, s, nr″, sir″2, asr″2 and cr″2; •m is a complexing metal; •x is selected from the group consisting of h, f, br, ci, i, otf, dba (dibenzylidene acetone), oc(═o)cf3 and oac; •l is selected from the group consisting of pr″2, nr″2, or″, sr″, sir″3, asr″3, alkene, alkyne, aryl and heteroaryl, each of said alkene, alkyne, aryl and heteroaryl being optionally substituted, for example with one or more halogens and/or with one or more r groups as defined herein; •each r is independently alkyl, cycloalkyl, heterocyclyl, heterocycloalkyl, aryl or -, heteroaryl; •d is absent or is ═s or —o or —z-linker-z—, where each z independently is o or nh or n-alkyl and linker is an alkyl chain of 2-5 carbon atoms in length; •each r″ is independently h, alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each other than h being optionally substituted, or r″2 is —z-linker-z— as defined above; and •m is 0 or 1 or 2; wherein if m is 0, n is 1, n′ and n″ are 0 and -- is absent; and if m is 1 or 2, n is 1 or 2 and n′ and n″ are integers such that the coordination sphere of m is filled, and d is absent..
Agency For Science, Technology And Research

Bioelastomers and applications thereof

In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties.
The Penn State Research Foundation

Reversible and irreversible chemisorption in nonporous, crystalline hybrid structures

A sorbent in the form of a layered, non-porous perovskite is provided, wherein the sorbent can include parallel, alternating layers of an organic layer, including an ordered array of organic moieties capable of reacting with a gaseous halogen, and an inorganic layer, including a metal-halide sheet. Furthermore, each organic layer can be sandwiched between inorganic layers.
The Board Of Trusteees Of The Leland Stanford Junior University

Process for synthesizing highly optically active 1,3-disubstituted allenes

The present invention relates to a process for efficiently synthesizing highly optically active 1,3-disubstituted allenes, i.e., a one-step process for preparing highly optically active 1,3-disubstituted allenes by using a functionalized terminal alkyne, an aldehyde and a chiral α,α-diphenyl prolinol as reactants under the catalysis of a divalent copper salt. The operation of the process is simple, and the raw materials and reagents are readily available.

Spiroannulated nucleosides and process for the preparation thereof

We claim a simple strategy for the synthesis of a collection of c(3′)-spirodihydroisobenzo-furannulated and c(3′)-spirodihydroisobenzo-furannulated nucleosides featuring a [2+2+2]-cyclotrimerization as the key reaction. The cyclotrimerization reactions are facile with the unprotected nucleosides having a diyne unit.

Heterocyclylalkyne derivatives and their use as modulators of mglur5 receptors

Their use as allosteric modulators of mglur5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction, such as schizophrenia or cognitive decline, dementia or cognitive impairment, or other pathologies that can be related directly or indirectly to glutamate dysfunction.. .

System and converting gaseous hydrocarbon mixtures into highly-branched hydrocarbons using electron beam combined with electron beam-sustained non-thermal plasma discharge

A system and method converts first carbon chain condensable fractions of wet natural gas, the first carbon chain fractions having first carbon chains, into liquefiable highly-branched hydrocarbons by cavitating first carbon chain condensable fractions of wet natural gas with natural gas; irradiating the natural gas cavitated condensable fractions of wet natural gas with an electron beam to create second carbon chain fractions; mixing the second carbon chain fractions with natural gas enriched with alkynes and alkenes to a create enriched natural gas and second carbon chain fractions mixture; irradiating the enriched natural gas and second carbon chain fractions mixture with an electron beam to create an irradiated gas mixture; cooling the irradiated gas mixture; and removing liquefied highly-branched hydrocarbons.. .

Selective detection of alkenes or alkynes

A detector can detect an analyte including a carbon-carbon multiple bond moiety and capable of undergoing diels-alder reaction with a heteroaromatic compound having an extrudable group. The detector can detect, differentiate, and quantify ethylene..
Massachusetts Institute Of Technology

Silylated polyarylenes

Polyarylenes comprising as polymerized units a first monomer having two cyclopentadienone moieties and a second monomer having two or more alkyne moieties, wherein at least one alkyne moiety is directly bonded to a silicon atom are provided. Such polyarylenes are useful as dielectric materials in the manufacture of electronic devices..
Rohm And Haas Electronic Materials Korea Ltd.

A the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides

Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during dna polymerase-mediated replication of dna or rna polymerase-mediated transcription of rna. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded dna or rna), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker..
Synthorx, Inc.

Cycloalkyne derivatized saccharides

This disclosure provides novel saccharide derivatives, conjugates, and methods for making the derivatives and conjugates.. .
Glaxosmithkline Biologicals Sa

Alkyne phosphoramidites and preparation of spherical nucleic acid constructs

The present disclosure is directed to compositions comprising alkyne oligonucleotides, nanoconjugates prepared from the same, and methods of their use.. .
Northwestern University

Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds

1,3-dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed.
University Of Georgia Research Foundation, Inc.

Traceless directing groups in radical cascades: from oligoalkynes to fused helicenes without tethered initators

The present disclosure is directed to a traceless directing group in a radical cascade. The chemo- and regioselectivity of the initial attack in skipped oligoalkynes is controlled by a propargyl alkoxy moiety.
The Florida State University Research Foundation, Inc.

Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives

Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography/computed tomography are disclosed. In one version of the method, the stilbene derivative is a compound of formula (x):.
Mayo Foundation For Medical Education And Research

Polymer suitable for use in cell culture

A process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process includes the steps of: i) copolymerizing a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is 1:500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula a-l-b, wherein the linking group and group a are chosen to react and form a first coupling and the cell adhesion factor and group b are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornmadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin-strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol-carboxylic acid coupling resulting in esters linkages and nhs-ester (n-hydroxysuccinimide ester)-amine coupling and wherein group l is a linear chain segment having 10-60 bonds between atoms selected from c, n, o and s in the main chain.. .
Stichting Katholieke Universiteit

Atomic layer deposition of films comprising si(c)n using hydrazine, azide and/or silyl amine derivatives

Provided are methods for the deposition of films comprising si(c)n via atomic layer deposition processes. The methods include exposure of a substrate surface to a silicon precursor and a co-reagent comprising a compound selected from the group consisting of n═n═n—r, r2n—nr2, and (r3si)qnh3-q, wherein q has a value of between 1 and 3, and each r is independently selected from organosilicons, c1-c6 substituted or un-substituted alkanes, branched or un-branched alkanes, substituted or un-substituted alkenes, branched or un-branched alkenes, substituted or un-substituted alkynes, branched or un-branched alkynes or substituted or un-substituted aromatics..
Applied Materials, Inc.

Synthesis of olefinic alcohols via enzymatic terminal hydroxylation

In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes p450 (e.g., cytochromes p450 of the cyp52 and cyp153 family), as well as long chain alkane hydroxylases.

Platinum catalyzed hydrosilylation reactions utilizing cyclodiene additives

A process and composition for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a platinum compound and (d) a cyclodiene, with the proviso that when the unsaturated compound is a terminal alkyne, the silyl hydride is other than a halosilane. The process and composition optionally comprise an inhibitor (e).

Synthesis of 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate and analogs

4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate salt was synthesized and isolated. The pentafluorosulfanyl salt was examined in a wide assortment of reactions to form novel sf5-bearing alkenes, alkynes, and biaryl derivatives using heck-matsuda, sonogashira, and suzuki coupling protocols.
University Of North Florida

Direct anti-markovnikov addition of acids to alkenes

A method of making an anti-markovnikov addition product, comprises reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Dual catalyst composition useful for carrying out such methods are also described..
The University Of North Carolina At Chapel Hill

Conversion of acetylene and methanol to aromatics

Methods are provided for forming aromatic compounds from a highly unsaturated aliphatic feeds optionally in combination with methanol. The method can include dehydrogenating a feed containing at least about 50 vol % c1-c4 alkanes under dehydrogenation conditions to form a dehydrogenation effluent containing at least about 25 vol % alkynes.
Exxonmobil Chemical Patents Inc.

Functionalized 4- and 5-vinyl substituted regioisomers of 1, 2, 3-triazoles via 1, 3- dipolar cycloaddition and polymers thereof

The present invention provides novel functionalized mixtures 4- and 5-vinyl substituted regioisomers of 1,2,3-triazoles via 1,3-dipolar cycloaddition. Functionalized alkyne moieties with a terminal alcoholic functionality are reacted with functionalized organic moieties with a terminal leaving group and an azide to provide an alcoholic functionalized mixture of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties.
Isp Investments Inc.

Engineered strain of escherichia coli for production of poly-r-3-hydroxyalkanoate polymers with defined monomer unit composition and methods based thereon

Methods and systems for producing prescribed unit size azido-poly(3-hydroxyalkanoate) (azido-pha) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of pha or lack enzymes to degrade pha once synthesized, metabolize short to long chain fatty acids without induction, and express an (r)-specific enoyl-coa hydratase and a pha synthase, the (r)-specific enoyl-coa hydratase and pha synthase having wide substrate specificities.
The Research Foundation For The State University Of New York

Base-catalyzed silylation of terminal alkyne c-h bonds

The present invention is directed to a mild, efficient, and general direct c(sp)-h bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl c—h bond, with a mixture of at least one organosilane and an alkali metal hydroxide, under conditions sufficient to form a silylated terminal alkynyl moiety.
California Institute Of Technology

Modified polyaryletherketone polymer (paek) and process to obtain it

The present invention relates to a modified polyaryletherketone polymer (paek) with chemically modified surfaces with azides, alkynes, thiols, maleimides, sulfonylazides or thio acids, suitable for “click” reactions and to a process to obtain it. It also relates to the conjugated biomaterials derived thereof, paek type materials with surfaces modified with a rgd (arg-gly-asp) and/or ogp10-14 (tyr-gly-phe-gly-gly) peptidomimetics and to a process to obtain it.
Fundacion Tecnalia Research & Innovation

Process for the diastereoselective preparation of ruthenium complexes

The present invention relates to a process for the preparation of a compound of formula (i), wherein x is —ch2—, —ch2—ch2—, —ch2—ch2—ch2— or —ch2—ch2—ch2—ch2—; y1 is —ch2—; —ch2—ch2— or —nh—; y2 is nhr7, or sh; wherein r7 is hydrogen, c1-c4alkyl or phenyl; r—1 and r2, independently from each other, represent aliphatic or aromatic groups; r3 and r4, independently from each other, represent aliphatic or aromatic groups; r5 and r6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula ii [ruci2(r8)n]m (ii), wherein n is 1 and m is >1 which represents a polymeric structure if r8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if r8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 112° c. To 165° c.
Syngenta Participations Ag



Alkyne topics:
  • Small Molecule Library
  • Electrocatalytic
  • Organic Molecules
  • Disassembly
  • Organic Molecule
  • Tomography
  • Positron Emission Tomography
  • Computed Tomography
  • Meningioma
  • Robustness
  • Obstruction
  • Oligonucleotide
  • Nucleotide
  • Radiotherapy
  • Metallic Compound


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    This listing is a sample listing of patent applications related to Alkyne for is only meant as a recent sample of applications filed, not a comprehensive history. There may be associated servicemarks and trademarks related to these patents. Please check with patent attorney if you need further assistance or plan to use for business purposes. This patent data is also published to the public by the USPTO and available for free on their website. Note that there may be alternative spellings for Alkyne with additional patents listed. Browse our RSS directory or Search for other possible listings.


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