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Alkyne patents

      

This page is updated frequently with new Alkyne-related patent applications.




Date/App# patent app List of recent Alkyne-related patents
08/18/16
20160237212 
 Methods for post-fabrication functionalization of poly(ester ureas) patent thumbnailnew patent Methods for post-fabrication functionalization of poly(ester ureas)
Amino acid-based poly(ester urea)s (peu) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of peus carrying pendent “clickable” groups on modified tyrosine amino acids.
The University Of Akron


08/11/16
20160229860 
 Bicyclic alkyne derivatives and uses thereof patent thumbnailBicyclic alkyne derivatives and uses thereof
The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the map kinase interacting kinases mnk2a, mnk2b, mnk1a, and mnk1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the prevention and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, autoimmune diseases, metabolic diseases, and neurodegenerative diseases (e.g.
Agency For Science, Technology And Research


08/11/16
20160229829 
 Method for producing asymmetric conjugated diyne compound and  producing z,z-conjugated diene compound using the same patent thumbnailMethod for producing asymmetric conjugated diyne compound and producing z,z-conjugated diene compound using the same
Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride and a method for producing a z,z-conjugated diene compound from the asymmetric conjugated diyne compound thus obtained. More specifically, provided is a method for producing an asymmetric conjugated diyne compound comprising a step of subjecting a terminal alkyne compound (1): hc≡c—z1—y1 to a coupling reaction with an alkynyl halide (2) y2—z2—c≡c—x by using sodium borohydride in water and an organic solvent in the presence of a copper catalyst and a base to obtain the asymmetric conjugated diyne compound (3): y2—z2—c≡c—c≡c—z1—y1.
Shin-etsu Chemical Co., Ltd.


08/04/16
20160225991 
 Amine precursors for depositing graphene patent thumbnailAmine precursors for depositing graphene
The present invention relates to the use of an amine precursor of formula i (x1—r1)n—nh(3-n) (i) or its ammonium salts for depositing a graphene film having a nitrogen content of from 0 to 65% by weight on a substrate s1 by chemical vapor deposition (cvd), wherein r1 is selected from (a) c1 to c10 alkanediyl, which may all optionally be interrupted by at least one of o, nh and nr2, (b) alkenediyl, which may all optionally be interrupted by at least one of o, nh and nr2, (c) alkynediyl, which may all optionally be interrupted by at least one of o, nh and nr2, (d) c6 to c20 aromatic divalent moiety, and (e) co and ch2co, x1 is selected from h, oh, or2, nh2, nhr2, or nr22, wherein two groups x1 may together form a bivalent group x2 being selected from a chemical bond, o, nh, or nr2, r2 is selected from c1 to c10 alkyl and a c6 to c20 aromatic moiety which may optionally be substituted by one or more substituents x1, n is 1, 2, or 3.. .
Max-planck-gesellschaft Zur FÖrderung Der Wissenschaften E.v.


08/04/16
20160222237 
 Ink compositions comprising surfactants having limited solubility patent thumbnailInk compositions comprising surfactants having limited solubility
Disclosed herein are ink compositions comprising a self-dispersed pigment in a liquid vehicle. The liquid vehicle can comprise a solvent/water mixture in which the composition further comprises a surfactant system having limited solubility/compatibility with the liquid vehicle.
Cabot Corporation


08/04/16
20160222195 
 Inorganic filler, resin composition comprising the same and heat radiation substrate using the same patent thumbnailInorganic filler, resin composition comprising the same and heat radiation substrate using the same
An inorganic filler according to an embodiment of the present invention includes a boron nitride agglomerate and a coating layer formed on the boron nitride agglomerate and including a —si—r—nh2 group, and r is selected from the group consisting of an alkyl group having 1 to 3 carbon atoms, an alkene group having 2 to 3 carbon atoms, and an alkyne group having 2 to 3 carbon atoms.. .
Lg Innotek Co., Ltd.


08/04/16
20160222151 
 Lignin-containing polymers patent thumbnailLignin-containing polymers
Click reactions may be used to bond polymers to lignin by taking advantage of lignin's terminal hydroxyl and thiol groups via an alkyne-azide click reaction or a thiol-alkene or thiol-alkyne click reaction. By selecting functional polymers, these methods may be used to synthesize lignin-containing polymer materials with an array of different properties, such as self-healing polymers..
Florida State University Research Foundation, Inc.


07/28/16
20160214946 
 Catalysed ligation of azides and acetylenes patent thumbnailCatalysed ligation of azides and acetylenes
A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting a solution of an organic azide and a terminal alkyne with a source of catalytic ru ion to form a 1,4-disubstituted 1,2,3-triazole..
The Scripps Research Institute


07/28/16
20160214913 
 Hydrogenation reactor and process patent thumbnailHydrogenation reactor and process
A reactor and process for removing unsaturated alkynes and diolefinic impurities from olefins and oxygenates is described.. .
Saudi Basic Industries Corporation


07/21/16
20160207034 
 Phosphorus-containing catalysts patent thumbnailPhosphorus-containing catalysts
The invention provides compounds of general structure i: (ar1—ar2—ar3-e-p(=d)r2-)nmmxnln″. In this structure: •ar1, ar2 and ar3 are aromatic groups wherein: —ar1 and ar3 are in a 1,3 relationship on ar2, —each of ar1, ar2 and ar3 optionally comprises one or more ring substituents of formula yr′r wherein each y independently is absent or is o, s, b, n or si and each r′ is independently h, halogen, alkyl, cycloalkyl, aryl or heteroaryl and r is 1, 2 or 3, where r is 1 if y is absent or is o or s, 2 if y is b or n and 3 if y is si, —ar1, ar2 and ar3 are each independently carbocyclic or heterocyclic and each is independently monocyclic, bicyclic or polycyclic and each ring of each of ar1, ar2 and ar3 independently has 5, 6 or 7 ring atoms; •e is absent or is selected from the group consisting of o, s, nr″, sir″2, asr″2 and cr″2; •m is a complexing metal; •x is selected from the group consisting of h, f, br, ci, i, otf, dba (dibenzylidene acetone), oc(═o)cf3 and oac; •l is selected from the group consisting of pr″2, nr″2, or″, sr″, sir″3, asr″3, alkene, alkyne, aryl and heteroaryl, each of said alkene, alkyne, aryl and heteroaryl being optionally substituted, for example with one or more halogens and/or with one or more r groups as defined herein; •each r is independently alkyl, cycloalkyl, heterocyclyl, heterocycloalkyl, aryl or -, heteroaryl; •d is absent or is ═s or —o or —z-linker-z—, where each z independently is o or nh or n-alkyl and linker is an alkyl chain of 2-5 carbon atoms in length; •each r″ is independently h, alkyl, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, each other than h being optionally substituted, or r″2 is —z-linker-z— as defined above; and •m is 0 or 1 or 2; wherein if m is 0, n is 1, n′ and n″ are 0 and -- is absent; and if m is 1 or 2, n is 1 or 2 and n′ and n″ are integers such that the coordination sphere of m is filled, and d is absent..
Agency For Science, Technology And Research


07/14/16
20160199541 

Bioelastomers and applications thereof


In one aspect, compositions are described herein. In some embodiments, a composition described herein comprises the reaction product of (i) citric acid, a citrate, or an ester of citric acid with (ii) a polyol, and (iii) a monomer comprising one or more alkyne moieties and/or azide moieties.
The Penn State Research Foundation


07/07/16
20160193566 

Reversible and irreversible chemisorption in nonporous, crystalline hybrid structures


A sorbent in the form of a layered, non-porous perovskite is provided, wherein the sorbent can include parallel, alternating layers of an organic layer, including an ordered array of organic moieties capable of reacting with a gaseous halogen, and an inorganic layer, including a metal-halide sheet. Furthermore, each organic layer can be sandwiched between inorganic layers.
The Board Of Trusteees Of The Leland Stanford Junior University


06/30/16
20160185812 

Process for synthesizing highly optically active 1,3-disubstituted allenes


The present invention relates to a process for efficiently synthesizing highly optically active 1,3-disubstituted allenes, i.e., a one-step process for preparing highly optically active 1,3-disubstituted allenes by using a functionalized terminal alkyne, an aldehyde and a chiral α,α-diphenyl prolinol as reactants under the catalysis of a divalent copper salt. The operation of the process is simple, and the raw materials and reagents are readily available.

06/30/16
20160185811 

Spiroannulated nucleosides and process for the preparation thereof


We claim a simple strategy for the synthesis of a collection of c(3′)-spirodihydroisobenzo-furannulated and c(3′)-spirodihydroisobenzo-furannulated nucleosides featuring a [2+2+2]-cyclotrimerization as the key reaction. The cyclotrimerization reactions are facile with the unprotected nucleosides having a diyne unit.

06/30/16
20160185798 

Heterocyclylalkyne derivatives and their use as modulators of mglur5 receptors


Their use as allosteric modulators of mglur5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction, such as schizophrenia or cognitive decline, dementia or cognitive impairment, or other pathologies that can be related directly or indirectly to glutamate dysfunction.. .

06/30/16
20160184791 

System and converting gaseous hydrocarbon mixtures into highly-branched hydrocarbons using electron beam combined with electron beam-sustained non-thermal plasma discharge


A system and method converts first carbon chain condensable fractions of wet natural gas, the first carbon chain fractions having first carbon chains, into liquefiable highly-branched hydrocarbons by cavitating first carbon chain condensable fractions of wet natural gas with natural gas; irradiating the natural gas cavitated condensable fractions of wet natural gas with an electron beam to create second carbon chain fractions; mixing the second carbon chain fractions with natural gas enriched with alkynes and alkenes to a create enriched natural gas and second carbon chain fractions mixture; irradiating the enriched natural gas and second carbon chain fractions mixture with an electron beam to create an irradiated gas mixture; cooling the irradiated gas mixture; and removing liquefied highly-branched hydrocarbons.. .

06/16/16
20160169810 

Selective detection of alkenes or alkynes


A detector can detect an analyte including a carbon-carbon multiple bond moiety and capable of undergoing diels-alder reaction with a heteroaromatic compound having an extrudable group. The detector can detect, differentiate, and quantify ethylene..
Massachusetts Institute Of Technology


06/16/16
20160168419 

Silylated polyarylenes


Polyarylenes comprising as polymerized units a first monomer having two cyclopentadienone moieties and a second monomer having two or more alkyne moieties, wherein at least one alkyne moiety is directly bonded to a silicon atom are provided. Such polyarylenes are useful as dielectric materials in the manufacture of electronic devices..
Rohm And Haas Electronic Materials Korea Ltd.


06/16/16
20160168187 

A the site-specific enzymatic labelling of nucleic acids in vitro by incorporation of unnatural nucleotides


Provided herein are analogs of unnatural nucleotides bearing predominantly hydrophobic nucleobase analogs that form unnatural base pairs during dna polymerase-mediated replication of dna or rna polymerase-mediated transcription of rna. In this manner, the unnatural nucleobases can be introduced in a site-specific way into oligonucleotides (single or double stranded dna or rna), where they can provide for site-specific cleavage, or can provide a reactive linker than can undergo functionalization with a cargo-bearing reagent by means of reaction with a primary amino group or by means of click chemistry with an alkyne group of the unnatural nucleobase linker..
Synthorx, Inc.


06/16/16
20160166704 

Cycloalkyne derivatized saccharides


This disclosure provides novel saccharide derivatives, conjugates, and methods for making the derivatives and conjugates.. .
Glaxosmithkline Biologicals Sa


06/09/16
20160159834 

Alkyne phosphoramidites and preparation of spherical nucleic acid constructs


The present disclosure is directed to compositions comprising alkyne oligonucleotides, nanoconjugates prepared from the same, and methods of their use.. .
Northwestern University


06/09/16
20160159732 

Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds


1,3-dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed.
University Of Georgia Research Foundation, Inc.


05/26/16
20160145276 

Traceless directing groups in radical cascades: from oligoalkynes to fused helicenes without tethered initators


The present disclosure is directed to a traceless directing group in a radical cascade. The chemo- and regioselectivity of the initial attack in skipped oligoalkynes is controlled by a propargyl alkoxy moiety.
The Florida State University Research Foundation, Inc.


05/26/16
20160144060 

Imaging of meningiomas using phenylbenzothiazole, stilbene, or biphenylalkyne derivatives


Methods for detecting or ruling out a meningioma in a patient using a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative, and a medical imaging technique such as positron emission tomography/computed tomography are disclosed. In one version of the method, the stilbene derivative is a compound of formula (x):.
Mayo Foundation For Medical Education And Research


05/19/16
20160137977 

Polymer suitable for use in cell culture


A process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process includes the steps of: i) copolymerizing a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is 1:500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula a-l-b, wherein the linking group and group a are chosen to react and form a first coupling and the cell adhesion factor and group b are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornmadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin-strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol-carboxylic acid coupling resulting in esters linkages and nhs-ester (n-hydroxysuccinimide ester)-amine coupling and wherein group l is a linear chain segment having 10-60 bonds between atoms selected from c, n, o and s in the main chain.. .
Stichting Katholieke Universiteit


05/12/16
20160133460 

Atomic layer deposition of films comprising si(c)n using hydrazine, azide and/or silyl amine derivatives


Provided are methods for the deposition of films comprising si(c)n via atomic layer deposition processes. The methods include exposure of a substrate surface to a silicon precursor and a co-reagent comprising a compound selected from the group consisting of n═n═n—r, r2n—nr2, and (r3si)qnh3-q, wherein q has a value of between 1 and 3, and each r is independently selected from organosilicons, c1-c6 substituted or un-substituted alkanes, branched or un-branched alkanes, substituted or un-substituted alkenes, branched or un-branched alkenes, substituted or un-substituted alkynes, branched or un-branched alkynes or substituted or un-substituted aromatics..
Applied Materials, Inc.


04/21/16
20160108436 

Synthesis of olefinic alcohols via enzymatic terminal hydroxylation


In certain aspects, the present invention provides methods for producing terminally hydroxylated alkenes and alkynes by contacting an unsaturated or saturated hydrocarbon substrate with a hydroxylase enzyme. Exemplary terminal hydroxylases useful for carrying out the methods of the invention exhibit strong selectivity towards one terminal carbon of a hydrocarbon substrate and include, but are not limited to, non-heme diiron alkane monooxygenases, cytochromes p450 (e.g., cytochromes p450 of the cyp52 and cyp153 family), as well as long chain alkane hydroxylases.

04/14/16
20160102178 

Platinum catalyzed hydrosilylation reactions utilizing cyclodiene additives


A process and composition for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a platinum compound and (d) a cyclodiene, with the proviso that when the unsaturated compound is a terminal alkyne, the silyl hydride is other than a halosilane. The process and composition optionally comprise an inhibitor (e).

04/07/16
20160096852 

Synthesis of 4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate and analogs


4-(pentafluorosulfanyl)benzenediazonium tetrafluoroborate salt was synthesized and isolated. The pentafluorosulfanyl salt was examined in a wide assortment of reactions to form novel sf5-bearing alkenes, alkynes, and biaryl derivatives using heck-matsuda, sonogashira, and suzuki coupling protocols.
University Of North Florida


04/07/16
20160096791 

Direct anti-markovnikov addition of acids to alkenes


A method of making an anti-markovnikov addition product, comprises reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Dual catalyst composition useful for carrying out such methods are also described..
The University Of North Carolina At Chapel Hill


03/31/16
20160090334 

Conversion of acetylene and methanol to aromatics


Methods are provided for forming aromatic compounds from a highly unsaturated aliphatic feeds optionally in combination with methanol. The method can include dehydrogenating a feed containing at least about 50 vol % c1-c4 alkanes under dehydrogenation conditions to form a dehydrogenation effluent containing at least about 25 vol % alkynes.
Exxonmobil Chemical Patents Inc.


03/24/16
20160083356 

Functionalized 4- and 5-vinyl substituted regioisomers of 1, 2, 3-triazoles via 1, 3- dipolar cycloaddition and polymers thereof


The present invention provides novel functionalized mixtures 4- and 5-vinyl substituted regioisomers of 1,2,3-triazoles via 1,3-dipolar cycloaddition. Functionalized alkyne moieties with a terminal alcoholic functionality are reacted with functionalized organic moieties with a terminal leaving group and an azide to provide an alcoholic functionalized mixture of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties.
Isp Investments Inc.


03/17/16
20160076064 

Engineered strain of escherichia coli for production of poly-r-3-hydroxyalkanoate polymers with defined monomer unit composition and methods based thereon


Methods and systems for producing prescribed unit size azido-poly(3-hydroxyalkanoate) (azido-pha) polymers and copolymers are provided. The methods and systems can employ recombinant bacteria that are not native producers of pha or lack enzymes to degrade pha once synthesized, metabolize short to long chain fatty acids without induction, and express an (r)-specific enoyl-coa hydratase and a pha synthase, the (r)-specific enoyl-coa hydratase and pha synthase having wide substrate specificities.
The Research Foundation For The State University Of New York


03/03/16
20160060278 

Base-catalyzed silylation of terminal alkyne c-h bonds


The present invention is directed to a mild, efficient, and general direct c(sp)-h bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl c—h bond, with a mixture of at least one organosilane and an alkali metal hydroxide, under conditions sufficient to form a silylated terminal alkynyl moiety.
California Institute Of Technology


02/25/16
20160053042 

Modified polyaryletherketone polymer (paek) and process to obtain it


The present invention relates to a modified polyaryletherketone polymer (paek) with chemically modified surfaces with azides, alkynes, thiols, maleimides, sulfonylazides or thio acids, suitable for “click” reactions and to a process to obtain it. It also relates to the conjugated biomaterials derived thereof, paek type materials with surfaces modified with a rgd (arg-gly-asp) and/or ogp10-14 (tyr-gly-phe-gly-gly) peptidomimetics and to a process to obtain it.
Fundacion Tecnalia Research & Innovation


02/18/16
20160046658 

Process for the diastereoselective preparation of ruthenium complexes


The present invention relates to a process for the preparation of a compound of formula (i), wherein x is —ch2—, —ch2—ch2—, —ch2—ch2—ch2— or —ch2—ch2—ch2—ch2—; y1 is —ch2—; —ch2—ch2— or —nh—; y2 is nhr7, or sh; wherein r7 is hydrogen, c1-c4alkyl or phenyl; r—1 and r2, independently from each other, represent aliphatic or aromatic groups; r3 and r4, independently from each other, represent aliphatic or aromatic groups; r5 and r6 are each hydrogen or represent together with the carbon atoms to which they are bonded, a phenyl ring; which process comprises reacting a compound of formula ii [ruci2(r8)n]m (ii), wherein n is 1 and m is >1 which represents a polymeric structure if r8 is a molecule containing two alkene or alkyne moieties coordinating in an hapto-2 coordination mode to the metal; or n is 4 and m is 1 if r8 is a nitrogen, oxygen or sulfur containing molecule in which said nitrogen, oxygen or sulfur coordinate to the metal; in the presence of an inert solvent which boiling point is from 112° c. To 165° c.
Syngenta Participations Ag


02/11/16
20160039965 

Method and device for high density data storage


A local probe storage array is provided that includes a substrate, and a polymeric layer over the substrate, the polymeric layer comprising a crosslinking agent comprising at least three alkyne groups.. .
International Business Machines Corporation


02/04/16
20160032059 

Radiation curable polythioethers with alkyne-based linkage


Certain polythioether polymers are presented, as well as compositions which are radiation curable to polythioether polymers and seals and sealants comprising same. The compositions radiation curable to polythioether polymers include those comprising: a) at least one dithiol monomer; b) at least one diene monomer; c) at least one polyyne monomer comprising at least two ethyne groups; and d) at least one photoinitiator.
3m Innovative Properties Company


02/04/16
20160031860 

Alkyne substituted quinazoline compound and methods of use


The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (i), which are irreversible erbb kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where erbb kinase activity is implicated such as a hyperproliferative disorder (e.g., cancer)..
Newgen Therapeutics, Inc.


01/21/16
20160016977 

Alkaline earth metal-complexed metal bisamides


The present invention relates to alkaline earth metal-complexed metal bisamides of the formula (i), to a process for preparation thereof and to the use thereof for metallation of aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated c—h bonds.. .
Bayer Cropscience Ag


12/24/15
20150368530 

Synthesis of polyurethane polymers via copper azide-alkyne click chemistry for coatings, adhesives, sealants and elastomer applications


The present application is directed at the reaction product of an azide compound having two or more azide groups attached thereto and an alkyne compound having two or more alkyne groups attached thereto, wherein the azide and alkyne groups react in a 1,3-dipolar cyclo addition to form 1,4-disubstituted triazols and wherein the azide or alkyne compound or both include —o—(c═o)—nr— functional groups. The reaction products can be used as coatings, such as for flat roofs, sealants, adhesives and in elastomer applications.
Sika Technology Ag


12/24/15
20150368295 

Method for producing pyrazoles, novel pyrazoles and applications thereof


A method for preparing a pyrazole of formula (i) in which r,r′ and r″ have different meanings, characterised in that it involves reacting a sydnone of formula (ii) in which r and r′ have the meanings already indicated, with an alkyne of formula (iii) in which r″ has the meaning already indicated, in the presence of copper, to obtain a pyrazole compound of formula (i) that is then isolated and salified if desired.. .
Commissariat A L'energie Atomique Et Aux Energies Alternatives


12/24/15
20150368277 

Preparation of alkaline earth metal-complexed metal bisamides from metal monoamides


The present invention relates to a process for preparing alkaline earth metal-complexed metal bisamides of the formula (i) from metal monoamides of the formula (ii). The present invention further relates to a process for preparing alkaline earth metal monoamides of the formula (ii-ae), to novel licl-free alkaline earth metal monoamides of the formula (ii-ae-l), and to the use of these alkaline earth metal monoamides for metallation of aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated c—h bonds..
Bayer Cropscience Aktiengesellschaft


12/24/15
20150368207 

Method for treating macrophage migration inhibitory factor (mif)-implicated diseases and conditions with iodo pyrimidine derivatives


Wherein a is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; b is h, oh, or, sr, nh2, nhr, or alkyl; r is h or alkyl, and x and y are independently n or ch, but one of x and y must be n. Also provided are pharmaceutical compositions that contain a formula i compound and methods for the treatment of mif-implicated diseases or conditions that include administering a safe and effective amount of a formula i compound..

12/17/15
20150361112 

Platinum catalyzed hydrosilylation reactions utilizing cyclodiene additives


A process for the hydrosilylation of an unsaturated compound comprising reacting (a) a silyl hydride with (b) an unsaturated compound in the presence of (c) a platinum compound and (d) a cyclodiene, with the provisos that (i) when the unsaturated compound is a terminal alkyne, the silyl hydride is other than a halosilane, and (ii) when the platinum compound is a pt(ii)-based compound, the ratio of total moles of cyclodiene to moles of platinum is less than 3:1.. .
Momentive Performance Materials Inc.


12/17/15
20150361111 

Catalytic obtaining substituted (triorganosilyl)alkynes and their derivatives


New (triorganosilyl)alkynes and their derivatives having general formula r1—c≡c—z are provided along with methods for the preparation of (triorganosilyl)alkynes and their derivatives having the general formula r1—c≡c—z. The methods may include silylative coupling of terminal alkynes with halogenotriorganosilanes in the presence of an iridium catalyst and a tertiary amine..
Adam Mickiewicz University


12/10/15
20150353509 

A compound 1,4,5-trisubstituted1,2,3-triazole, process to obtain and uses thereof


The present invention relates to compounds, containing a central 1,4,5-trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent “click” bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups. These compound are nonpeptide mimetics of rgd (arg-gly-asp) and/or, ogp10-14 (tyr-gly-phe-gly-gly), osteogenic peptides.
Centro De InvestigaciÓn Biomedica Enred En Red


12/03/15
20150344506 

Novel phosphinine oxide derivative and preparation method thereof


In addition, according to the preparation method of the phosphinine oxide derivative according to the present invention, various phosphinine oxide derivatives with a high yield may be prepared by a simple synthesis process using an intramolecular annulation between a phosphinic derivative and an alkyne derivative in the presence of a rhodium (rh) catalyst or a ruthenium (ru) catalyst and an oxidant.. .

12/03/15
20150344448 

Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer


Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as cetzole compounds, are useful to treat non-small cell lung cancer and other forms of cancer.
The University Of Toledo


12/03/15
20150344392 

Method of preparing z-alkene-containing insect pheromones


Insect pheromones and pheromone precursors, containing one or more z-alkenyl groups, are prepared by treating an alkyne with a copper complex, reducing agent, and proton donor in an organic solvent. The pheromones and pheromone precursors are prepared with high stereoselectivity and substantially no over reduction..
Suterra, Llc


11/19/15
20150329487 

Improved synthesis of succinimides and quaternary ammonium ions for use in making molecular sieves


The present invention relates to the synthesis of succinimides, in particular to a method for the synthesis of a succinimide compound, comprising the step of reacting an alkyne, with carbon monoxide and ammonia or an amine, in the presence of an iron catalyst, wherein the reaction is carried out in an amine liquid phase and/or in the absence of an ether solvent. The succinimides may be reduced to quaternary ammonium cations which may be used as structure directing agents in the synthesis of molecular sieves..
Exxonmobil Chemical Patents Inc.


11/12/15
20150322433 

Post-synthetic orthoganal amidation plus metal catalyzed azide-alkyne cycloaddition click chemistry on sirna


This invention relates to the post-synthetic chemical modifications of rna at the 2′-position on the ribose rings via orthogonal chemistry involving amidation reactions plus metal catalyzed alkyne-azide cycloaddition (click) reactions.. .
Sirna Therapeutics, Inc.


11/05/15
20150315214 

Method for the hydrosilylation of a siloxane photocatalysed by a polyoxometalate compound


The invention concerns a method of hydrosilylation between a siloxane compound (a) comprising at least one hydrogen atom bonded to a silicon atom and an unsaturated compound (b) comprising at least one alkene function and/or at least one alkyne function, the method being characterized in that it is catalysed by a photocatalyst selected from among the polyoxometalates.. .
Bluestar Silicones France Sas


10/29/15
20150309041 

Reactive labelling compounds and uses thereof


Provided are azido-bodipy compounds of formula (i), cyclooctyne-based fluorogenic probes of formula (iv), and activity-based probes of formula (vi). These compounds undergo azide alkyne cycloadditions (aac) with to form triazolyl products.
Academia Sinica


10/22/15
20150299343 

Polymer plasticizing agents that produce polymers that do not release endocrine disrupting compounds


Disclosed are novel phthalate compounds and a simple and economical route to covalently attach a phthalate ester mimic to pvc is described, allowing plasticization of pvc without the danger of endocrine disruption chemicals leaching from the polymer matrix. An azide-alkyne husigen cycloaddition (in the absences of copper catalyst) using dialkyl acetylenedicarboxylates allows this cycloaddition to occur under very mild thermal conditions..
The Regents Of The University Of California


10/22/15
20150299202 

Heteroaryl alkyne compound and use thereof


In the field of pharmaceutical chemistry compounds of general formula i having heteroaryl alkynyl moiety or pharmaceutically acceptable salts, isomers, solvates, crystals or prodrugs thereof, and pharmaceutical compositions including these compounds, as well as uses of these compounds and compositions thereof in the manufacture of a medicament. The compounds have a strong inhibitory effect on bcr-abl tyrosine kinase and are useful for treating diseases, such as tumors..
Nanjing Sanhome Pharmaceutical Co., Ltd.


10/22/15
20150297680 

Compositions and methods for increasing protein half-life


In order to extend the serum half-life of a protein, we exploited the site-specific fatty acid-conjugation to a permissive site of a protein, using copper-catalyzed alkyne-azide cycloaddition, by linking a fatty acid derivative to p-ethynylphenylalanine incorporated into a protein using an engineered pair of yeast trna/aminoacyl trna synthetase. As a proof-of-concept, we show that single palmitic acid conjugated to superfolder green fluorescent protein (sfgfp) in a site-specific manner enhanced a protein's albumin-binding in vitro about 20 times and the serum half-life in vivo 5 times when compared to those of the unmodified sfgfp.
University Of Virginia Patent Foundation


10/15/15
20150295905 

Identity management with generic bootstrapping architecture


A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas.

10/08/15
20150284486 

Peg-based microparticles


Synthesis of monodisperse peg-based microparticles with stable coupling chemistries. Biomolecules are conjugated to monodisperse peg microparticles using non-amine chemistries, such as sulfhydryl groups, azide, or alkyne-based chemistries..

10/01/15
20150276752 

Alkyne-activated fluorogenic azide compounds and methods of use thereof


The present disclosure provides fluorogenic azide compounds. Also provided are methods of using the subject compounds for labelling a target biomolecule that includes an alkyne.
The Regents Of The University Of California


10/01/15
20150273457 

Highly active multidentate catalysts for efficient alkyne metathesis


The invention relates to highly active and selective catalysts for alkyne metathesis. In one aspect, the invention includes a multidentate organic ligand wherein one substrate-binding site of the metal center is blocked.
The Regents Of The University Of Colorado, A Body Corporate


09/24/15
20150267196 

Biodegradable hydrogel for polynucleotide delivery


A composition includes a biodegradable hydrogel that includes a hydrogel forming base polymer and a plurality of physiologically degradable ester linkages, amide linkages, azide-alkyne cycloaddition linkages, acrylate-thiol linkages, urethane linkages, and/or methacrylate-thiol linkages, a polynucleotide coupling polymeric molecule; and a polynucleotide. The polynucleotide is released under physiological conditions in a spatial and/or temporally controlled or predetermined manner from the composition..
Case Western Reserve University


09/24/15
20150267002 

Novel composite compositions and methods of preparing and using same


The present invention includes compositions comprising an alkyne-based substrate, an azide-based substrate, optionally a cu(ii) salt and optionally a photoinducible reducing agent. The present invention further includes a method of preparing composite materials that are suitable for use as dental implants using the compositions of the invention..
The Regents Of The University Of Colorado, A Body Corporate


09/10/15
20150252061 

Bodipy dyes for biological imaging


This invention relates to water-soluble mono-alkoxy and mono-alkyne bodipy derivatives, including methods for a making the same. For examples, provided herein are compounds of formula (i): (i) or a pharmaceutically acceptable salt thereof wherein: (a) is a bod1py ligand system; x is a halogen; l is absent or a linker; and z is selected from the group consisting of: a group reactive with a biologically active molecule and a detectable agent..
The General Hospital Corporation


08/27/15
20150241439 

Benzocyclooctyne compounds and uses thereof


Provided are benzocyclooctyne compounds of formula (i). These compounds undergo strain-promoted azide-alkyne cyclo additions (spaac) without presence of toxic metal catalysts.
Academia Sinica


08/27/15
20150240006 

Solid-phase supports and uses thereof


The present disclosure relates to solid-phase azide supports, methods for making solid-state azide supports, and methods for capturing alkynes using the same. The present disclosure also relates to kits for solid-phase azide supports.
Indiana University Research And Technology Corporation


08/27/15
20150239868 

Alkyne compounds for treatment of complement mediated disorders


Compounds, methods of use, and processes for making inhibitors of complement factor d comprising formula i, or a pharmaceutically acceptable salt or composition thereof, wherein r12 or r13 on the a group is an alkyne (r32) are provided. The inhibitors described herein target factor d and inhibit or regulate the complement cascade at an early and essential point in the alternative complement pathway, and reduce factor d's ability to modulate the classical and lectin complement pathways.
Achillion Pharmaceuticals, Inc.


08/20/15
20150232432 

Copper-catalysed ligation of azides and acetylenes


A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting a solution of an organic azide and a terminal alkyne with a source of catalytic cu(i) ion to form a 1,4-disubstituted 1,2,3-triazole, wherein the source of cu(i) ion comprises cu(ii) and a metal capable of reducing cu(ii) to cu(i).
The Scripps Research Institute


08/06/15
20150218203 

Multiple orthogonal labelling of oligonucleotides


In summary, the present invention concerns a method for multiple orthogonal labelling of oligonucleotides, preferably rna or dna, by simultaneously performing the inverse diels-alder reaction (dainv) and the copper-catalyzed click reaction (cuaac), wherein the method is employed in a single step by just adding the different reaction components together and incubating the aqueous reaction mixture preferably for one hour at room temperature. In detail, the reaction components are one or more n3-modified labels, a copper compound, a stabilizing ligand, a reducing agent and one or more electron-deficient label-modified dienes that are added together with an at least double-modified oligonucleotide having one more nucleotides containing one or more n3-reactive groups and one or more electron-rich dienophiles, wherein a terminal alkyne moiety is preferably used as n3-reactive group(s) and a frans-cyclooctene moiety or norbornene is preferably used as electron-rich dienophile(s), more preferably frans-cyclooctene.
Deutsches Krebsforschungszentrum


07/16/15
20150197600 

Polymeric structures containing strained cycloalkyne functionality for post-fabrication azidealkyne cycloaddition functionalization


A method of creating biocompatible polymeric structures includes the steps of: providing a biocompatible polymer including a strained cycloalkyne end group; forming a polymeric structure from the biocompatible polymer such that the strained cycloalkyne end group remains on the biocompatible polymer; providing an azide tethered molecule; and, after forming the polymeric structure, reacting the azide tethered molecule with the cycloalkyne in an azide alkyne cycloaddition reaction to further functionalize the polymeric structure.. .
The University Of Akron


07/09/15
20150191497 

Novel phosphorus 2-pyrone derivative and preparation method thereof


Provided are a novel phosphorus 2-pyrone derivative and a preparation method thereof. The phosphorus 2-pyrone derivative according to the present invention is capable of being efficiently synthesized by treating an alkyl hydrogen alkynylphosphonate derivative and an alkyne derivative with a minimal amount of a gold catalyst..
Knu-industry Cooperation Foundation


07/02/15
20150183988 

Strain-promoted crosslinking of peg-based hydrogels via copper-free cycloaddition


The present invention is directed to a covalently crosslinked hydrogel comprising the strain-promoted reaction product of an 8-member cycloalkyne functionalized polyalkylene glycol and a multi-arm glycerol exytholate triazide and methods for making them. Because the precursor materials can be manipulated without causing crosslinking, provided the strain threshold is not reached, these hydrogels permit mechanical control over when (and where) cross linking occurs and are easier to use than prior strain-activated or temperature-activated systems.
The University Of Akron


07/02/15
20150183887 

Cellulose ethers having reactive anchor group, modified cellulose ethers obtainable therefrom and methods for the preparation thereof


Non-ionic water-soluble cellulose ethers modified with 3-azido-2-hydroxypropyl groups bound via an ether link are provided having a molar degree of substitution msahp in the range from 0.001 to 0.50. Exemplary cellulose ethers are alkyl cell doses, including methyl, hydroxyalkyl (e.g.
Se Tylose Gmbh & Co. Kg


06/25/15
20150175854 

Hydrogenated alkenyl aromatic-diene copolymers containing comonomers having silyl hydride units and their functionalized analogs


The present invention relates primarily to polymers comprising at least one alkenyl aromatic monomer, at least one conjugated diene monomer, and at least one monomer containing silyl hydride moieties, characterized in that said polymers are hydrogenated and preferably functionalized by hydrosilylation reactions between the silyl hydride groups on the polymer chain and the multiple bonds of any alkene or alkyne compound. Besides the described products, this invention comprises their synthesis processes and their uses, especially as thermofusible adhesives, in plastics impact modification, and in chain-extension reactions to obtain new materials, among others..
Dynasol Elastomeros, S.a.


06/18/15
20150164750 

Dental restorative materials based on polymerizable azides and alkynes


The invention also relates to the use of the dental restorative materials according to the invention for preparing dental composites, preferably composite blanks, which are suitable in particular for mechanical processing by means of computer-aided processing techniques such as milling and grinding processes, and which are suitable above all for preparing dental restoration materials such as inlays, onlays, crowns, bridges or veneering materials.. .

06/11/15
20150158931 

Cysteine protease capturing agents


The invention concerns cysteine protease capturing agents capable of highly selective and irreversible binding of the corresponding cysteine protease. Such compounds may have utility in fundamental biological research and diagnostics, e.g.
Stichting Het Nederlands Kanker Instituut


06/11/15
20150158854 

Quinazoline compounds, preparing the same and use thereof


Wherein g is a heteroaryl, heterocyclic or alkyne; x is n or ch; l1 is —n(r7)—, —o—, —c(s)—, —c(o)—, or —s—; l2 is —n(r8)— or —o—; r1 and r2 are independently hydrogen, halogen, hydroxyl, amino, cyano, nitro, carboxy, c1-c4 alkoxy, c1-c4 alkoxy c1-c4 alkoxy, n,n—(c1-c4 dialkyl)amino c1-c4 alkoxy, n—(c1-c4 alkyl)amino c1-c4 alkoxy, c1-c4 alkanoyl, c1-c4 alkanoyloxy, n—(c1-c4 alkyl)amino, n,n—(c1-c4 dialkyl)amino, c1-c4 alkanoyl amino, or heterocyclyl, wherein c1-c4 alkyl is optionally substituted with one or more substituents selected from fluorine and chlorine; r3, r4 and r5 are independently hydrogen, fluorine or chlorine; r6 is c1-c4 alkyl or aryl, which is optionally substituted with one or more substituents selected from halogen, hydroxyl, amino, cyano, nitro; or r6 and r8 form a 5-6 membered cyclyl or heterocyclyl.. .

06/11/15
20150157744 

Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivatives


A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas.

05/21/15
20150140640 

Process for growing natural or engineered high lipid accumulating strain on crude glycerol and/or other sources of waste carbon for the production of oils, fuels, oleochemicals, and other valuable organic compounds


Disclosed herein are microorganisms capable of growing on crude glycerol and/or glycerol and/or methanol, or combinations thereof. In some embodiments the microorganisms are knallgas bacteria that produce or secrete at least 10% of lipid by weight.
Kiverdi, Inc.


05/14/15
20150133680 

Direct anti-markovnikov addition of acids to alkenes


A method of making an anti-markovnikov addition product is carried out by reacting an acid with an alkene or alkyne in a dual catalyst reaction system to the exclusion of oxygen to produce said anti-markovnikov addition product; the dual catalyst reaction system comprising a single electron oxidation catalyst in combination with a hydrogen atom donor catalyst. Compositions useful for carrying out such methods are also described..

05/07/15
20150126744 

Metal complexes, their application and methods of carrying out of metathesis reaction


This disclosure relates to new metal complexes, such as compounds of formula 1, and their application in olefin or alkyne metathesis and to methods of carrying out olefin metathesis reactions.. .
Apeiron Synthesis S.a.


05/07/15
20150126706 

Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds


1,3-dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed.
University Of Georgia Research Foundation, Inc.


04/09/15
20150099108 

Method for producing a hard material layer on a substrate, hard material layer and cutting tool


A process for producing a hard material layer on a substrate includes depositing a ticnb hard material layer by chemical vapor deposition (cvd) from a gas system including a titanium source, a boron source, at least one nitrogen source and at least one carbon source, in which the carbon source includes an alkane having at least two carbon atoms, an alkene or an alkyne. A cutting tool includes a substrate to which a ticnb hard material layer has been applied, in which a ratio of carbon atoms (c) to nitrogen atoms (n) in the ticxnyb1-x-y system deposited on the substrate is 0.70≦x≦1.0, preferably 0.75≦x≦0.85, and a polished section through the substrate and the hard material layer is substantially free of an eta phase following murakami etching..
Ceratizit Austria Gesellschaft Mbh


03/19/15
20150080581 

Multicoordinated metal complexes for use in metathesis reactions


Improved catalysts useful in alkyne or olefin metathesis are made by bringing into contact a multi-coordinated metal complex comprising a multidentate schiff base ligand, and one or more other ligands, with a selected activating compound under conditions such that at least partial cleavage of a bond between the metal and the multidentate schiff base ligand of said metal complex occurs.. .
Rimtec Corporation


03/12/15
20150073145 

Modular synthesis of graphene nanoribbons and graphene substructures from oligo-alkynes


A method for the synthesis of carbon-based structures, particularly graphene substructures and ribbons, from oligo- and poly-alkyne starting materials.. .
The Florida State University Research Foundation, Inc.


03/05/15
20150065688 

Surfaces having nanoparticulate layers and assembly and use thereof


A method for generating layered structures is disclosed. The method comprises reacting an azide-functionalized material with an alkyne-functionalized material, one of which can be a nanoparticle or a microparticle and the other can be a substrate or another nanoparticle or microparticle.

02/05/15
20150037288 

Methods for increasing the infectivity of viruses


Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid.
The Johns Hopkins University


01/29/15
20150031895 

Copper-catalysed ligation of azides and acetylenes


A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive cu(i) ion in human blood plasma to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole.
The Scripps Research Institute


01/29/15
20150031886 

Alkaline earth metal-complexed metal amides


The present invention relates to metal amides of the formula (i), to a process for preparation thereof and to the use thereof as bases for aromatics, heteroaromatics, alkenes, alkynes and other organic compounds having activated c—h bonds.. .
Bayer Cropscience Ag


01/22/15
20150024037 

Xenoantigen-displaying anti-cancer vaccines and making


Compositions, methods of making, and methods of using, xenoantigen-displaying anticancer vaccines are described. In another broad aspect, there is provided herein a method of synthesizing an alkynefunctionalized composition of claim 1, comprising: deprotecting an ester comprising a fmoc moiety to form a free acid; coupling the free acid of step (a) with an amine; and, removing the fmoc moiety, and coupling the remaining moiety with palmitic acid to yield an alkyne-functionalized composition..
The University Of Toledo


01/15/15
20150017703 

Methods for increasing the infectivity of viruses


Methods of using viruses labeled with alkyne-modified biomolecules, such as fatty acids, carbohydrates and lipids, to treat a plant, an insect or an animal infected with a virus or to increase the infectivity of a virus, such as the human immunodeficiency virus, are provided. Also provided are methods of labeling a virus, such as human immunodeficiency virus, with an alkyne-modified biomolecule, such as a fatty acid, a carbohydrate, or an isoprenoid lipid.
Life Technologies Corporation


01/15/15
20150017694 

Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same


Disclosed herein are microorganisms containing exogenous or heterologous nucleic acid sequences, wherein the microorganisms are capable of growing on gaseous carbon dioxide, gaseous hydrogen, syngas, or combinations thereof. In some embodiments the microorganisms are chemotrophic bacteria that produce or secrete at least 10% of lipid by weight.
Kiverdi, Inc.


01/08/15
20150011513 

Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers


A triazole bridged flavonoid dimer compound library was efficiently constructed via the cycloaddition reaction of a series of flavonoid-containing azides (az 1-15) and alkynes (ac 1-17). These triazole bridged flavonoid dimers and their precursor alkyne- and azide-containing flavonoids were screened for their ability to modulate multidrug resistance (mdr) in p-gp-overexpressed cell line (lcc6mdr), mrp1-overexpressed cell line (2008/mrp1) and bcrp-overexpressed cell line (hek293/r2 and mcf7-mx100).
Mcgill University


01/01/15
20150005464 

Metalloporphyrin polymer functionalized substrate


A method is provided for fabricating a metalloporphyrin polymer on a substrate. The method creates a functionalized substrate by attaching an anchor group of a linker, including a terminal alkyne group, to a substrate surface.
Sharp Laboratories Of America, Inc.


12/11/14
20140364628 

Process for the preparation of benzodithiophene compounds


Process for the preparation of a benzodithiophene compound which comprises reacting at least one monohalogenated dithiophene compound with at least one internal alkyne. Said benzodithiophene compound, after suitable functionalization and polymerization, can be advantageously used in the construction of photovoltaic devices such as, for example, photovoltaic cells, photo-voltaic modules, solar cells, solar modules, on both rigid and flexible supports.

11/20/14
20140341804 

Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (pmsa) and uses thereof


The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of psma inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens.



Alkyne topics: Small Molecule Library, Electrocatalytic, Organic Molecules, Disassembly, Organic Molecule, Tomography, Positron Emission Tomography, Computed Tomography, Meningioma, Robustness, Obstruction, Oligonucleotide, Nucleotide, Radiotherapy, Metallic Compound

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