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Alkyne

Alkyne-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivitives
Mayo Foundation For Medical Education And Research
July 13, 2017 - N°20170196999

A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas. In one version of the method, the phenylbenzothiazole derivative ...
Heterocyclylalkyne derivatives and their use as modulators of mglur5 receptors
Mayo Foundation For Medical Education And Research
June 29, 2017 - N°20170182011

Their use as allosteric modulators of mglur5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction, such as schizophrenia or cognitive decline, dementia or cognitive impairment, or other pathologies that can be related directly or indirectly to glutamate dysfunction.
Polyurethane materials formed from unsaturated plant oils via an alkyne zipper reaction
International Business Machines Corporation
June 15, 2017 - N°20170166680

A process of forming a polyurethane material includes forming an alkyne-terminated triglyceride material from an unsaturated plant oil. The process also includes forming a hydroxyl-terminated polyol material from the alkyne-terminated triglyceride material. The process further includes polymerizing a mixture that includes the hydroxyl-terminated polyol material to form a polyurethane material.
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Engineered co2-fixing chemotrophic microorganisms producing carbon-based products and methods of using the same
Kiverdi, Inc.
June 01, 2017 - N°20170152533

Disclosed herein are microorganisms containing exogenous or heterologous nucleic acid sequences, wherein the microorganisms are capable of growing on gaseous carbon dioxide, gaseous hydrogen, syngas, or combinations thereof. In some embodiments the microorganisms are chemotrophic bacteria that produce or secrete at least 10% of lipid by weight. Also disclosed are methods of fixing gaseous carbon into organic carbon molecules useful for ...
Toxic rna inhibitors self-assembled in situ
Kiverdi, Inc.
May 25, 2017 - N°20170143703

Potent modulators of rna function can be assembled in cellulo by using the cell as a reaction vessel and a disease-causing rna as a catalyst. When designing small molecule effectors of function, a balance between permeability and potency must be struck. Low molecular weight compounds are more permeable while higher molecular weight compounds are more potent. The advantages of both ...
Tetracenothiophene derivatives with alkoxy-c-alkyne solubilising units and their applications as organic semiconductors
Sumitomo Chemical Company Limited
May 11, 2017 - N°20170133605

Tetracenothiophene derivatives are disclosed, which comprise alkoxy-c-alkyne solubilising groups at transversal positions of the tetracenothiophene unit. These compounds enable preferential molecular stacking and a high field effect mobility and at the same time show improved solubility as compared to known benzothiophene- and pentacene-based materials. In addition, organic thin films comprising these derivatives, their use in electronic devices and components, such ...
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Platinum(iv) compounds and methods of making and using same
University Of Georgia Research Foundation, Inc.
April 06, 2017 - N°20170096443

Reactions of 1,3-dipole-functional (e. G., azide-functional) platinum(iv) compounds with cyclic alkynes under conditions effective for a cycloaddition reaction to form a heterocyclic compound are disclosed herein. In certain embodiments, the conditions effective for the cycloaddition reaction to form the heterocyclic compound includes the substantial absence of added catalyst (e. G., copper catalyst).
Base-catalyzed silylation of terminal alkyne c-h bonds
California Institute Of Technology
March 30, 2017 - N°20170088563

The present invention is directed to a mild, efficient, and general direct c(sp)-h bond silylation. Various embodiments includes methods, each method comprising or consisting essentially of contacting at least one organic substrate comprising a terminal alkynyl c—h bond, with a mixture of at least one organosilane and an alkali metal hydroxide, alkali metal alkoxide, or alkali ...
Sydnone derivatives for conjugation of compounds of interest
Commissariat A L'energie Atomique Et Aux Energies Alternatives
March 23, 2017 - N°20170081300

The present invention relates to a process for the preparation of a first compound of interest c1 functionalized with a sydnone compound and to the corresponding functionalized c1 compound of interest. The present invention also relates to a process for the preparation of a conjugate of two compounds of interest c1 and c2 implying a sydnone compound and to the ...
Composition for manufacturing semiconductor device and method of manufacturing semiconductor device using the composition
Samsung Electronics Co., Ltd.
March 02, 2017 - N°20170062217

A composition for manufacturing a semiconductor device includes at least one carbon-based compound that includes at least one of an alkyne group and an azide group, and a solvent. A method of manufacturing a semiconductor device includes forming a feature layer on a substrate, coating the feature layer with a composition including alkyne and azide, forming a carbon-containing layer including ...
Inorganic filler, resin composition comprising the same and heat radiation substrate using the same
Lg Innotek Co., Ltd.
March 02, 2017 - N°20170058107

An inorganic filler according to an embodiment of the present invention includes a boron nitride agglomerate and a coating layer formed on the boron nitride agglomerate and including a —si—r—nh2 group, and r is selected from the group consisting of an alkyl group having 1 to 3 carbon atoms, an alkene group having 2 to 3 carbon atoms, and ...
Resin composition suitable for printing and printing method utilizing the same
MontanuniversitÄt Leoben
February 23, 2017 - N°20170051112

The present invention relates to a resin composition, in particular suitable for printing, a kit comprising the components of the resin composition, a printing method utilizing the resin composition, a polymer obtained by the printing method, an article comprising or formed from the polymer, and uses thereof. The resin composition may be in particular suitable for printing and comprises at ...
Homomultivalent and heteromultivalent inhibitors of prostate specific membrane antigen (psma) and uses thereof
The Johns Hopkins University
February 23, 2017 - N°20170049912

The present invention provides bivalent and multivalent ligands with a view to improving the affinity and pharmacokinetic properties of a urea class of psma inhibitors. The compounds and their synthesis can be generalized to multivalent compounds of other target antigens. Because they present multiple copies of the pharmacophore, multivalent ligands can bind to receptors with high avidity and affinity, thereby ...
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D-amino acid derivative-modified peptidoglycan and methods of use thereof
The Regents Of The University Of California
January 26, 2017 - N°20170021013

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified d-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified d-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via ...
Polyarylene materials
Rohm And Haas Electronic Materials Llc
January 12, 2017 - N°20170009006

Polyarylene oligomers formed from an aromatic dialkyne monomer having a solubility enhancing moiety show improved solubility in certain organic solvents and are useful in forming dielectric material layers in electronics applications.
Process for the cycloaddition of a halogenated 1,3-dipole compound with a (hetero)cycloalkyne
Synaffix B.v.
January 12, 2017 - N°20170008858

The present invention relates to a cycloaddition process comprising the step of reacting a halogenated aliphatic 1,3-dipole compound with a (hetero)cycloalkyne according to formula (1): preferably, the (hetero)cycloalkyne according to formula (1) is a (hetero)cyclooctyne. The invention also relates to the cycloaddition products obtainable by the process according to the invention. The invention further relates to halogenated aliphatic 1,3-dipole ...
Peptide/beta-1,3-glucan complex and production method thereof and pharmaceutical composition containing peptide/beta-1,3-glucan ...
Japan Science And Technology Agency
January 12, 2017 - N°20170007695

This peptide/β-1,3-glucan complex includes β-1,3-glucan and a peptide/polynucleotide conjugate in which an antigenic peptide is bonded covalently to a polynucleotide or a derivative thereof. The polynucleotide or derivative thereof of the peptide/polynucleotide conjugate bonds via a hydrogen bond with β-1,3-glucan, forming a complex having a triple helix structure ...
Process for the cycloaddition of a hetero(aryl) 1,3-dipole compound with a (hetero)cycloalkyne
Japan Science And Technology Agency
January 05, 2017 - N°20170002012

And wherein the (hetero)cycloalkyne is a (hetero)cyclooctyne or a (hetero)cyclononyne according to formula (1). The invention also relates to the products obtainable by the process according to the invention.
Synthesis of mahanine and related compounds
Georgetown University
December 22, 2016 - N°20160368927

Disclosed herein are methods of synthesizing mahanine and related compounds. The synthesis features an intramolecular aryl-alkyne isomerization, transition metal catalyzed cross-coupling and intramolecular carbazole forming reaction.
Palladium/silver co-catalyzed tandem reactions synthesis of phenylacetophenone derivatives by oxabenzonorbornadienes with terminal alkynes and ...
Yunnan Minzu University
December 22, 2016 - N°20160368890

This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes
Raman-active polymer particles and methods for synthesizing thereof
The Trustees Of Columbia University In The City Of New York
December 22, 2016 - N°20160367688

An exemplary raman-active nanoparticle can be provided, which can include, for example, a hydrophilic cyclopropenium cation, and one or more copolymers derived from a hydrophobic organic polymerizable molecule, where the hydrophobic organic polymerizable molecule can be a raman-active molecule, and where the ramain-active nanoparticle can be free of heavy metals. In some exemplary embodiments of the present disclosure, the hydrophobic ...
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