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Alkyne

Alkyne-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Alkyne substituted quinazoline compound and methods of use
Newgen Therapeutics, Inc.
April 05, 2018 - N°20180093975

The invention provides alkyne substituted quinazoline compounds, such as compounds of the formula (i), which are irreversible erbb kinase inhibitors. The compounds are useful in the treatment of diseases and disorders where erbb kinase activity is implicated such as a hyperproliferative disorder (e. G., cancer).
Photodegradable hydrogel, culture device, method for forming tissue, and method for separating cells
National Institute Of Advanced Industrial Science And Technology
March 29, 2018 - N°20180086883

Provided are a photodegradable hydrogel in which cells can be embedded in the photodegradable gel without causing cytotoxicity when the cells are embedded in the photodegradable gel by allowing the cells to coexist at the time of preparation of the photodegradable gel, and which contains a protein as one of the main components; a culture device using the same; a ...
Amine-boranes as organic ligands for surface functionalization
Purdue Research Foundation
March 15, 2018 - N°20180076403

The present invention relates to a process for functionalizing a surface of semi-conductors, conductors, and dielectrics using an amine-borane bearing a functionality from a group of, but not limited to, alkene, alkyne, hydroxyl, thiol, acetal, ester, amide, nitrile, nitro, or alkoxysilane, under a mild condition. Products of this facile process are also in the scope of this disclosure.
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Polymerizable composition and novel alkyne compound
March 08, 2018 - N°20180066082

Wherein, in general formula (1), x1 and x2 represent a sulfur atom, an oxygen atom, or an nh group and may be the same or different from each other, q represents an alkylene group having 1 or 2 carbon atoms, a carbonyl group, or a thiophenylene group in which one of carbon atoms is substituted by an antimony atom, r1 and r2 represent ...
Click-chemistry compatible structures, click-chemistry functionalized structures, and materials and methods for making the same
Lawrence Livermore National Security, Llc
March 01, 2018 - N°20180059540

According to several embodiments, a composition of matter includes: a three-dimensional structure comprising photo polymerized molecules. At least some of the photo polymerized molecules further comprise one or more protected click-chemistry compatible functional groups; and at least portions of one or more surfaces of the three-dimensional structure are functionalized with one or more of the protected click-chemistry compatible functional groups. ...
Amine-boranes bearing borane-intolerant functionalities
Purdue Research Foundation
February 22, 2018 - N°20180051040

Disclosed herein is the preparation of functional group containing amine-boranes from the corresponding amines. The mild reaction conditions allow for the direct preparation of several hitherto inaccessible amine-boranes containing a functional moiety, such as but not limited to, alkene, alkyne, hydroxyl, thiol, acetal, ester, amide, nitrile, nitro, and alkoxysilane.
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Degradable thiol-ene polymers and methods of making thereof
Mosaic Biosciences, Inc.
February 15, 2018 - N°20180043030

Provided are methods for linking polypeptides (including peptides and proteins) to other moieties using radical imitated thiol-ene chemistries, for example, modifying a polypeptide by introducing reactive thiol groups and reacting the thiol groups with olefin-containing reagents or alkyne-containing reagents under conditions that support radical thiol-ene or thiol-yne reactions. The reactive thiol groups have greater activity for radical thiol-ene reactions that ...
Pyrolytic reactor and method of using
Uop Llc
February 08, 2018 - N°20180036698

Methods and apparatus to produce alkynes are described. The method includes combusting fuel and an oxidizer in a combustion zone to create a carrier gas stream, which is accelerated to supersonic speed in an expansion zone. A feedstock material is injected into a feedstock injection zone using two or more pluralities of injection nozzles. The injection nozzles are arranged annularly. ...
Disulfide-containing alkyne linking agents
Arrowhead Pharmaceuticals, Inc.
January 25, 2018 - N°20180023084

Described are improved disulfide-containing alkyne linking agents having have branched disulfides. The improved linking agents exhibit improved stability. The linking agents are useful for attachment of oligonucleotides to targeting groups or delivery agents.
Reactive labelling compounds and uses thereof
Academia Sinica
January 11, 2018 - N°20180011104

Provided are azido-bodipy compounds of formula (i), cyclooctyne-based fluorogenic probes of formula (iv), and activity-based probes of formula (vi). These compounds undergo azide-alkyne cycloadditions (aac) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
The University Of Toledo
January 11, 2018 - N°20180009772

Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as cetzole compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using ...
Method for treating macrophage migration inhibitory factor (mif)-implicated diseases and conditions with iodo pyrimidine ...
January 11, 2018 - N°20180009764

Wherein a is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; b is h, oh, or, sr, nh2, nhr, or alkyl; r is h or alkyl, and x and y are independently n or ch, but one of x and y must be n. Also provided are pharmaceutical compositions that contain ...
D-amino acid derivative-modified peptidoglycan and methods of use thereof
The Regents Of The University Of California
January 04, 2018 - N°20180000929

The present disclosure provides modified bacteria and modified peptidoglycan comprising modified d-amino acids; compositions comprising the modified bacteria or peptidoglycan; and methods of using the modified bacteria or peptidoglycan. The modified d-amino acids include a bioorthogonal functional group such as an azide, an alkyne or a norbornene group. Also provided are modified peptidoglycans conjugated to a molecule of interest via ...
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Universal method for functionalization of dyed microspheres
The United States Government As Represented By The Secretary Of The Arm Y
December 07, 2017 - N°20170349754

Provided are processes of functionalizing a microparticle that include reacting a microparticle expressing a carboxylic acid with a functionalization linker including the structure n-l1-a where n is a free amine, l1 is a linker, and a is an azide and an alkyne terminated group, to form a functional group terminated microparticle, and forming a functionalized microparticle by reacting the ...
Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of ...
Dsm Ip Assets B.v.
December 07, 2017 - N°20170349563

The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.
Bis-thienobenzothienothipohene compounds and process for their preparation
Eni S.p.a.it
November 30, 2017 - N°20170342087

The present invention relates to bis-thienobenzothienothiophene compounds and a process for their preparation. More in particular, the present invention relates to a new angular bis-thienobenzothienothiophene compound and the process for its preparation wherein said process comprises reacting at least one dihalogenated dithiophene compound with at least one terminal alkyne and the subsequent double annulation reaction. Said bis-thienobenzothienothiophene compounds can be ...
Lignin-containing polymers
Florida State University Research Foundation, Inc.
November 23, 2017 - N°20170335042

Click reactions may be used to bond polymers to lignin by taking advantage of lignin's terminal hydroxyl and thiol groups via an alkyne-azide click reaction or a thiol-alkene or thiol-alkyne click reaction. By selecting functional polymers, these methods may be used to synthesize lignin-containing polymer materials with an array of different properties, such as self-healing polymers.
Triazabutadienes as cleavable cross-linkers
The Arizona Board Of Regents On Behalf Of The University Of Arizona
November 09, 2017 - N°20170320834

Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with dick chemistry, e. G., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e. G., azide handles disposed on other components) via dick chemistry. Also described ...
Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds
University Of Georgia Research Foundation, Inc.
November 09, 2017 - N°20170320815

1,3-dipole-functional compounds (e. G., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e. G., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a ...
Method of hydrosilylation implementing an organic catalyst derived from germylene
November 02, 2017 - N°20170313729

The present invention concerns a method for the hydrosilylation of an unsaturated compound comprising at least one ketone function, one aldehyde function, one alkene function and/or one alkyne function, with a compound comprising at least one hydrogen-silyl function implementing an organic catalyst of tri-coordinated germanium.
Method of identifying or producing an aptamer
October 19, 2017 - N°20170298343

The invention relates to a method of identifying or producing an aptamer, and a reagent comprising a nucleic acid ligand capable of binding a target sample, wherein the nucleic acid ligand comprises at least one nucleobase modified to contain an azide-alkyne chemical group.
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