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Alkyne

Alkyne-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).


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Reactive labelling compounds and uses thereof
Academia Sinica
January 11, 2018 - N°20180011104

Provided are azido-bodipy compounds of formula (i), cyclooctyne-based fluorogenic probes of formula (iv), and activity-based probes of formula (vi). These compounds undergo azide-alkyne cycloadditions (aac) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
Highly selective anti-cancer agents targeting non-small cell lung cancer and other forms of cancer
The University Of Toledo
January 11, 2018 - N°20180009772

Described herein are analogues of 2-methyl-3-(2-ethynylthiazol-4-yl)cyclopent-2-enol and the corresponding ketone 3-(2-ethynylthiazol-4-yl)-2-methylcyclopent-2-enone, the analogues having terminal alkyne groups at the 2-position of the thiazole ring. These drug-like molecules, referred to as cetzole compounds, are useful to treat non-small cell lung cancer and other forms of cancer. Methods of making and using ...
Method for treating macrophage migration inhibitory factor (mif)-implicated diseases and conditions with iodo pyrimidine ...
The University Of Toledo
January 11, 2018 - N°20180009764

Wherein a is selected from the group consisting of aromatic or non-aromatic rings, bicyclic rings, polycyclic rings, alkenes or alkynes; b is h, oh, or, sr, nh2, nhr, or alkyl; r is h or alkyl, and x and y are independently n or ch, but one of x and y must be n. Also provided are pharmaceutical compositions that contain ...
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Composition for manufacturing semiconductor device and method of manufacturing semiconductor device using the composition
Samsung Electronics Co., Ltd.
December 07, 2017 - N°20170352543

A composition for manufacturing a semiconductor device includes at least one carbon-based compound that includes at least one of an alkyne group and an azide group, and a solvent. A method of manufacturing a semiconductor device includes forming a feature layer on a substrate, coating the feature layer with a composition including alkyne and azide, forming a carbon-containing layer including ...
Universal method for functionalization of dyed microspheres
The United States Government As Represented By The Secretary Of The Arm Y
December 07, 2017 - N°20170349754

Provided are processes of functionalizing a microparticle that include reacting a microparticle expressing a carboxylic acid with a functionalization linker including the structure n-l1-a where n is a free amine, l1 is a linker, and a is an azide and an alkyne terminated group, to form a functional group terminated microparticle, and forming a functionalized microparticle by reacting the ...
Formation of chromanes based on intermolecular reaction of alkynes with dimethylfuran in the presence of ...
Dsm Ip Assets B.v.
December 07, 2017 - N°20170349563

The present invention relates to a method of preparing chromanes from 2,5-dimethylfuran and substituted alkynes comprising an long chain unsaturated alkyl group as substituent in the alpha position of a substituted phenol followed by oxidation, reduction and acid ring closure. It is particularly advantageous to use 2,5-dimethylfuran as this offers an ecological beneficial synthesis of β-tocopherol.
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Lignin-containing polymers
Florida State University Research Foundation, Inc.
November 23, 2017 - N°20170335042

Click reactions may be used to bond polymers to lignin by taking advantage of lignin's terminal hydroxyl and thiol groups via an alkyne-azide click reaction or a thiol-alkene or thiol-alkyne click reaction. By selecting functional polymers, these methods may be used to synthesize lignin-containing polymer materials with an array of different properties, such as self-healing polymers.
Triazabutadienes as cleavable cross-linkers
The Arizona Board Of Regents On Behalf Of The University Of Arizona
November 09, 2017 - N°20170320834

Triazabutadiene molecules as cleavable cross-linkers adapted to cross-link components with dick chemistry, e. G., clickable triazabutadienes. For example, in some embodiments, the triazabutadienes feature alkyne handles attached to the imidazole portion or the aryl portion of the triazabutadienes, wherein the alkyne handles can link to azide handles (e. G., azide handles disposed on other components) via dick chemistry. Also described ...
Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds
University Of Georgia Research Foundation, Inc.
November 09, 2017 - N°20170320815

1,3-dipole-functional compounds (e. G., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e. G., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a ...
Method of hydrosilylation implementing an organic catalyst derived from germylene
University Of Georgia Research Foundation, Inc.
November 02, 2017 - N°20170313729

The present invention concerns a method for the hydrosilylation of an unsaturated compound comprising at least one ketone function, one aldehyde function, one alkene function and/or one alkyne function, with a compound comprising at least one hydrogen-silyl function implementing an organic catalyst of tri-coordinated germanium.
Method of identifying or producing an aptamer
University Of Georgia Research Foundation, Inc.
October 19, 2017 - N°20170298343

The invention relates to a method of identifying or producing an aptamer, and a reagent comprising a nucleic acid ligand capable of binding a target sample, wherein the nucleic acid ligand comprises at least one nucleobase modified to contain an azide-alkyne chemical group.
Photochemical modification of a solid surface
University Of Georgia Research Foundation, Inc.
October 19, 2017 - N°20170297018

A process for the modification of a solid material, said process comprising contacting a surface of the solid material comprising nucleophilic groups with a hydrosilane in a first step to produce a hydrosilanized surface, and contacting said hydrosilanized surface with at least one alkene and/or alkyne under irradiation with visible and/or ultraviolet light in a second step.
Cu(i)-catalyzed azide-alkyne cycloadditions (cuaac) ligands and methods for carrying out cu(i)-catalyzed ...
University Of Georgia Research Foundation, Inc.
October 19, 2017 - N°20170297008

A cu(i)-catalyzed azide-alkyne cycloadditions (cuaac) ligand comprising: a catalytic core; a fluorous tag; and a linker binding the fluorous tag to the catalytic core. A method for carrying out a cu(i)-catalyzed azide-alkyne cycloaddition reaction, comprising: combining in a solution an alkyne-tagged component, an azide-tagged component and a cu(i)-catalyzed azide-alkyne cycloadditions (cuaac) ligand comprising: a ...
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Metal complexes based on a bis(2-pyridylmethyl)amine-based scaffold and methods of making the same
Lawrence Livermore National Security, Llc
August 24, 2017 - N°20170240569

A catalyst includes a bis(2-pyridylmethyl)amine-based ligand. A method of forming a catalyst, may include: reacting bis(2-pyridylmethyl)amine-based compound with a terminal azide and/or a terminal alkyne in the presence of cu(i) to form a bis(2-pyridylmethyl)amine-based ligand. A method of using such catalysts may include neutralizing toxicity of at least one organophosphorus-based compound by ...
Inorganic filler, resin composition comprising the same and heat radiation substrate using the same
Lg Innotek Co., Ltd.
August 17, 2017 - N°20170233554

An inorganic filler according to an embodiment of the present invention includes a boron nitride agglomerate and a coating layer formed on the boron nitride agglomerate and including a —si—r—nh2 group, and r is selected from the group consisting of an alkyl group having 1 to 3 carbon atoms, an alkene group having 2 to 3 carbon atoms, and ...
Covalently cross linked hydrogels and methods of making and using same
The Regents Of The University Of Colorado, A Body Corporate
August 17, 2017 - N°20170232143

A thiol-yne polymeric material and methods for producing said polymers are disclosed. The material is produced by the radically mediated polymerization of monomers having alkyne and thiol functional groups. The alkyne moiety, internal or terminal, may react with one or two thiols. Degradable monomers may be used to form degradable polymers.
Platinum-catalyzed silicone drug delivery devices and methods of use thereof
International Partnership For Microbicides, Inc.
August 10, 2017 - N°20170224823

The present invention provides intravaginal drug delivery devices, such as intravaginal rings, comprising active pharmaceutical ingredients (apis) having terminal alkene, alkyne or carbonyl functionalities. The devices of the invention exhibit increased recovery of the active pharmaceutical ingredient from platinum-catalyzed silicone polymers due to the optimization of drug particle size and cure conditions. The present invention also provides methods of preventing ...
Uncharged pyrenyloxy sulfonamide dyes for conjugation with biomolecules
International Partnership For Microbicides, Inc.
July 27, 2017 - N°20170210904

Wherein r1 is a leash joined to the pyrenyloxy group via an ether link containing generally a reactive functional group such as, activated carbonate, activated ester, amino group, azide or alkyne for conjugation with biomolecules; r2 and r3 are hydrogen atoms, or short alkyl chains, or cyclic rings with or without heteroatoms such as nitrogen, oxygen, sulfur, phosphorus. The spectral ...
Treatment of meningiomas using phenylbenzothiazole, stilbene, biphenylalkyne, or pyridine derivitives
Mayo Foundation For Medical Education And Research
July 13, 2017 - N°20170196999

A method and composition for treating a meningioma in a subject are disclosed. The method includes the step of administering to the subject a therapeutically effective amount of a composition including a cytotoxic agent associated with a phenylbenzothiazole derivative or a stilbene derivative or a biphenylalkyne derivative that accumulates within meningiomas. In one version of the method, the phenylbenzothiazole derivative ...
Heterocyclylalkyne derivatives and their use as modulators of mglur5 receptors
Mayo Foundation For Medical Education And Research
June 29, 2017 - N°20170182011

Their use as allosteric modulators of mglur5 receptor activity, pharmaceutical compositions containing the same, and methods of using the same as agents for the treatment and/or prevention of neurological and psychiatric disorders associated with glutamate dysfunction, such as schizophrenia or cognitive decline, dementia or cognitive impairment, or other pathologies that can be related directly or indirectly to glutamate dysfunction.
Polyurethane materials formed from unsaturated plant oils via an alkyne zipper reaction
International Business Machines Corporation
June 15, 2017 - N°20170166680

A process of forming a polyurethane material includes forming an alkyne-terminated triglyceride material from an unsaturated plant oil. The process also includes forming a hydroxyl-terminated polyol material from the alkyne-terminated triglyceride material. The process further includes polymerizing a mixture that includes the hydroxyl-terminated polyol material to form a polyurethane material.
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