 Patent Application Title |
Patent App Num. |
Date |
 Alkyne and alkene derivatives as sphingosine 1-phosphate-1 receptor modulators | 20130150331 | 20130613 |  The present invention relates to novel alkyne and alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
... | | Process and method for the efficient preparation of fullerynes | 20130144083 | 20130606 |  The preparation of novel fullerynes which are fullerenes (e.g. C60, C70, C80, etc.) that contain one or more alkyne functionalities and may contain additional functional groups such as hydroxyls, halogens, esters, haloesters, phenyl, oligo(ethylene glycol)s, perfluorinated alkyl chains, and the like. Two desired preparation routes are disclosed. The first one is the Fischer esterification in desired solvents using a special designed reactor in contrast to the heretofore initial Steglich reaction that results in side reactions and low yields. The second one uses acetylide Grignard reagents that have reduced nucleophilicity and higher stability in contrast to the use of heretofore initial lithium organyls or other Grignard reagents that would add to C60 with possible multi-additions in an uncontrollable manner.
... | | Catalysts for the alkyne metathesis | 20130144102 | 20130606 |  Organometallic compounds of the general formula (I), in which M=Mo, W, are claimed.
... | | Novel methods for the synthesis and purification of oligomers | 20130137861 | 20130530 |  wherein X is a phosphoramidite group, an H-phosphonate group, an acetal group, or an isocyanate; C is a direct bond or a cleavable adaptor represented by —Ca-Cb—; L is a hydrocarbyl chain; and H is a terminal alkyne or an activated cyclooctyne. The reagent of Formula (A) can be used in the synthesis and purification of oligonucleotides.
... | | Cement composition containing a substituted ethoxylated phenol surfactant for use in an oil-contaminated well | 20130098273 | 20130425 |  A well treatment composition comprises a surfactant comprising a substituted ethoxylated phenol having at least one substituent, 1 to 14 moles of ethylene oxide, and the substituent being an alkyl, alkene, or alkyne with a carbon chain length in the range of 4 to 25, wherein the substituted ethoxylated phenol is selected from the group consisting of: ortho-, para-, or meta-substituted ethoxylated phenol; cardanol ethoxylate; derivatives thereof; and combinations of any of the foregoing. Preferably, the surfactant comprises cardanol ethoxylate, a substituted cardanol ethoxylate, and derivatives thereof. A method of cementing in a subterranean formation comprises: introducing a cement composition into the subterranean formation, wherein the cement composition comprises: (A) cement; (B) water; and (C) the surfactant; and allowing the cement composition to set.
... | Subscribe to updates on this page: Alkyne RSS  | | Maltoside and phosphocholine derivatives, uses thereof and methods of preparing artificial lipid structures thereof | 20130096295 | 20130418 | | Disclosed are saccharide and phosphocholine derivatives. The derivatives include azide and alkyne derivatives which form one end of a variable length carbon chain. The opposite end of the variable length carbon chain is covalently linked to the saccharide or phosphocholine. The saccharide may be, for instance, a maltoside. The alkyne and azide derivatives of the saccharides and phosphocholine may be reacted together to form amphiphilic molecules useful in cellular membrane studies and applications. By adjusting the length of the carbon chain, the biochemical and biophysical properties of the resultant 1,4-disubstituted 1,2,3-triazole compounds may be custom tailored for the intended application. Resultant molecules may form micelles, bicelle, lipid bilayers and other like structures useful in the isolation and purification of membrane bound or membrane associated proteins and... | | Gold complexes | 20130035322 | 20130207 | | Gold (I) hydroxide complexes of the form Z-Au-OH and digold complexes of the form Z—Au-(μOH)—Au—Z where groups Z are two electron donors are provided. The groups Z may be carbenes, for example nitrogen containing heterocyclic carbenes (NHCs), phosphines or phosphites. The complexes can be used as catalysts, for example in reactions such as hydration of nitriles, skeletal arrangement of enynes, alkoxycyclisation of enynes, alkyne hydration, the Meyer-Shuster reaction, 3,3′ rearrangement of allylic acetates, cyclisation of propargylic acetates, Beckman rearrangements and hydroamination. The complexes can be used in medicine, for example in the treatment of cancer.
... | | Method for producing acyloxypyranone compound, method for producing alkyne compound, and method for producing dihydrofuran compound | 20130023018 | 20130124 | | An acylating agent and a hydrolase are caused to act on a hydroxypyranone represented by formula (I) in a water-containing organic solvent, to thereby produce an acyloxypyranone compound represented by formula (II) (wherein R1 represents an acyl group). Then, an acetylene organic metal compound represented by formula (III) (wherein R2 represents a hydrogen atom or a tri-substituted silyl group, and M represents an alkali metal atom, aluminum, or a magnesium monohalide) and a coordinating additive are caused to act on the acyloxypyranone compound represented by formula (II), to thereby produce an alkyne compound represented by formula (IV). The alkyne compound represented by formula (IV) is hydrolyzed with acid, to thereby produce a dihydrofuran compound represented by formula (V).
... | | Curable fluoroelastomer compositions | 20130012673 | 20130110 | | This invention relates to curable fluoroelastomer compositions comprising a) fluoroelastomers having either nitrile, alkyne or azide cure sites and b) fluorinated curatives containing diazide, dinitrile or dialkyne groups for reacting with cure sites on the fluoroelastomer. Fluoroelastomers having azide cure sites form crosslinks with curatives having dinitrile or dialkyne groups. Fluoroelastomers having nitrile or alkyne cure sites form crosslinks with curatives having diazide groups.
... | | Carboxylation of terminal alkynes | 20120323038 | 20121220 | | The present invention describes a process for converting a terminal alkyne into an alkynoic acid. In this process the alkyne is exposed to carbon dioxide in the presence of a copper (I) species, a base and a complexing agent capable of complexing copper (I).
... | | Cyclopropenones and the photochemical generation of cyclic alkynes therefrom | 20120295318 | 20121122 | | Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.
... | | Method for preparing organic/inorganic hybrid functionalized solids having a triazole ring | 20120296095 | 20121122 | | A process is described for the preparation of a functionalized hybrid solid with an organic-inorganic matrix, crystallized, bearing at least one reactive group based on a triazole ring, from a hybrid solid with an organic-inorganic matrix, MOF—NH2, comprising: i/ introduction, in a polar solvent S1, of said crystallized hybrid solid MOF—NH2, of at least one organic compound Q containing a nitride function N3 and at least one intermediate reagent R containing a nitrite function NO2, ii/ reaction of said reaction mixture, iii/ introduction in the reaction mixture of at least one reagent A bearing an alkyne function or an activated cyanide function, at least one Cu-based catalyst C and at least one polar solvent S2, iv/ reaction of said reaction mixture, v/ filtration and then washing... | | Dipeptide acetylene conjugates and a method for photocleavage of double strand dna by dipeptide acetylene conjugates | 20120288940 | 20121115 | | Photoreactive DNA cleaving conjugate compounds are provided comprising a DNA cleaving moiety which comprises an aryl alkyne group and a polyfunctional pH-regulated DNA-binding moiety which comprises at least one or two amino groups.
... | Subscribe to updates on this page: Alkyne RSS | | Method for functionalising a thermoset, crosslinked isocyanate-based polymeric solid material | 20120289621 | 20121115 | | The invention relates to a method for functionalising a thermoset, crosslinked isocyanate-based polymeric solid material which is made of isocyanate and isocyanate reactive components, at least one of which comprises an anchor component which has at least one anchor group. The anchor groups on the solid material are formed by terminal alkene and/or alkyne groups. To functionalise this polymeric solid material it is brought in contact with a solution which contains at least one functional component. This functional component comprises at least one thiol group and is allowed to bind covalently to the polymeric solid material by a free-radical addition reaction between the thiol groups on the functional component and the terminal alkene and/or alkyne anchor groups on the undissolved solid material. An effective functionalisation of... | | Photochromic compounds | 20120200907 | 20120809 | | A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent Q attached thereto, each Q independently being —N3, —CN, —COOR′, —CCR′, —C(R′)C(R′)R′, —OCOR′, —OCOOR′, —SR′, —OSO2R′″, and/or —CON(R′)R′, wherein each R′ is hydrogen, an unsubstituted or substituted alkyl group having from 1 to 18 carbon atoms; an unsubstituted or substituted aryl group, an unsubstituted or substituted alkene or alkyne group having from 2 to 18 carbon atoms, wherein the substituents are halo or hydroxyl and R″′ is —CF3 or a perfluorinated alkyl group having from 2 to 18 carbon atoms. The number, locations and nature of the constituents Q are dependent upon the structure of the photochromic compound.
... |
| Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems | 20120190098 | 20120726 | | Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.
... | | Non-aqueous electrolytic solution for lithium secondary battery and lithium secondary battery using the same | 20120183864 | 20120719 | | A non-aqueous electrolytic solution is advantageously used in preparation of a lithium secondary battery excellent in cycle characteristics. In the non-aqueous electrolytic solution for a lithium secondary battery, an electrolyte salt is dissolved in a non-aqueous solvent. The non-aqueous electrolytic solution further contains a vinylene carbonate compound in an amount of 0.01 to 10 wt. %, and an alkyne compound in an amount of 0.01 to 10 wt. %.
... | | New vinyl-alkynylsubstituted germanium compounds and method to obtain vinyl-alkynylsubstituted germanium compounds | 20120178952 | 20120712 | | New vinyl-alkynylsubstituted germanium compounds having the general formula 1 are the subject of the invention. The invention also relates to a new method of obtaining vinyl-alkynylsubstituted germanium compounds having the general formula 1. —A denotes: diethylgermyl —R denotes: triethylsilyl, 1-(trimethylsiloxy)-1-cyclohexyl The invention also provides a solution to the problem of the method of obtaining vinyl-alkynylsubstituted germanium compounds having the general formula 1, involving the germylative coupling reaction between a suitable substituted terminal alkyne and a suitable divinylsubstituted germanium compound in the presence of a ruthenium(II) complex as catalyst.
... | | Copper-catalysed ligation of azides and acetylenes | 20120165542 | 20120628 | | A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.
... | | Sulfur-containing macromolecules and methods for their preparation | 20120148958 | 20120614 | | A sulfur-containing macromolecule and a method of preparing the sulfur-containing macromolecule comprising a polymerization step are provided, where the sulfur-containing macromolecule contains internal units of formula (I) and the polymerization step is formula (II) wherein n is greater than 1, said precursor comprises alkyne having one or more acetylene groups and thiol having one or more thiol groups; and R is remainder of said thiol excluding said thiol groups, R′ is remainder of said alkyne excluding said acetylene groups, and R and R′ are selected from organic or organometallic groups.
... | | Alkyne and alkene derivatives as sphingosine 1-phosphate-1 receptor modulators | 20120142640 | 20120607 | | The present invention relates to novel alkyne and alkene derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of sphingosine-1-phosphate receptors.
... | | Click chemistry surface functionalization for resonant micro-cavity sensors | 20120107177 | 20120503 | | Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
... | | 18f-labeled azide compound, reagent for 18f-labeling and method for 18f-labeling of alkyne compound using same | 20120101266 | 20120426 | | [SELECTED DRAWING] None
... | | Cmp compositions and methods for suppressing polysilicon removal rates | 20120094489 | 20120419 | | The present invention provides a chemical-mechanical polishing (CMP) composition suitable for polishing a silicon nitride-containing substrate while suppressing polysilicon removal from the substrate. The composition comprises abrasive particles suspended in an acidic aqueous carrier containing a surfactant comprising an alkyne-diol, an alkyne diol ethoxylate, or a combination thereof. Methods of polishing a semiconductor substrate therewith are also disclosed.
... | | Novel silane compounds having a cyclic carbon chain including an alkyne function for functionalising solid substrates and immobilising biological molecules on said substrates | 20120095203 | 20120419 | | The invention relates to a silane compound including a cycloalkyne functionality, to a method for functionalising a solid substrate, and to the solid substrate thus produced. The silane compound of the invention corresponds to the formula X-E-A-Z where X is a silyl group, E is an organic spacer group, A is a single bond or a —CONH—, —NHCO—, —OCH2CONH—, —NHCOCH2O—, —0— or —S— group, and Z is a cycloalkyne or heterocycloalkyne with at least 8 members. The invention is particularly suitable for use in the field of medicine.
... | | Novel preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | 20120077986 | 20120329 | | wherein R2 is the same as defined above; R3 is hydrogen atom, etc.; X is halogen atom, etc., are reacted in the presence of a base, a copper catalyst and a palladium catalyst in an aprotic polar solvent.
... | | Catalysts, methods of makting catalysts, and methods of use | 20120059182 | 20120308 | | Embodiments of the present disclosure provide for acyclic diaminocarbenes (ADCs) catalysts such as those shown in FIG. 1.1 and in the Examples, methods of making catalysts, methods of using catalysts, and the like. Catalyst of the present disclosure can be useful in various catalytic transformations. Embodiments of the catalyst can be used in hydroamination, cycloisomerization, allylic rearrangement reactions, alkyne hydration reactions, Meyer-Schuster rearrangement reactions, and the like.
... | | Cyclopropenones and the photochemical generation of cyclic alkynes therefrom | 20120053299 | 20120301 | | Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.
... | | Pretargeting kit, method and agents used therein | 20120039803 | 20120216 | | Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an alkene or alkyne dienohile.
... | | Functionalized 4- and 5-vinyl substituted regioisomers of 1, 2, 3-triazoles via 1, 3-dipolar cycloaddition and polymers thereof | 20120041040 | 20120216 | | The present invention provides novel functionalized mixtures 4- and 5-vinyl substituted regioisomers of 1,2,3-triazoles via 1,3-dipolar cycloaddition. Functionalized alkyne moieties with a terminal alcoholic functionality are reacted with functionalized organic moieties with a terminal leaving group and an azide to provide an alcoholic functionalized mixture of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties. The mixture may be converted to a wide variety of useful functionalized mixtures of 4- and 5-vinyl substituted regioisomers of 1,2,3-triazole moieties, which in turn can be converted to a wide variety of useful polymers The novel alcoholic functionalized mixtures of 4- and 5-substituted regioisomers can be separated by chromatography to provide the purified 4- and 5-alcoholic functionalized substituted 1,2,3-triazole moieties. The novel compounds of the invention can be employed in a wide... | | High voltage electrolyte | 20110008680 | 20110113 | | An organic electrolyte solvent includes a compound of the formula: R1—SO2—NR2—OR3 wherein R1 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives and perfluorinated analogues; R2 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives; R3 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives wherein the electrolyte solvent is stable at voltages of greater than 4.0 volts.
... | | Curable fluoroelastomer compositions | 20100324222 | 20101223 | | This invention relates to curable fluoroelastomer compositions comprising a) fluoroelastomers having either nitrile, alkyne or azide cure sites and b) fluorinated curatives containing diazide, dinitrile or dialkyne groups for reacting with cure sites on the fluoroelastomer. Fluoroelastomers having azide cure sites form crosslinks with curatives having dinitrile or dialkyne groups. Fluoroelastomers having nitrile or alkyne cure sites form crosslinks with curatives having diazide groups.
... | | Thiol-yne shape memory polymer | 20100311861 | 20101209 | | A shape memory polymer composition is described comprising an alkyne component and a thiol component.
... | | Process for preparation of cyclodextrin oligomers or polymers, products obtained and uses | 20100303754 | 20101202 | | A process for the preparation of cyclodextrin oligomers or polymers, whereby the cyclodextrin molecules are coupled to one another covalently via a spacer arm, based on a coupling reaction between an alkyne and an azide producing the formation of an aromatic heterocyclic bridge between the coupled units. Also described are the cyclodextrin oligomers or polymers that are obtained and their uses.
... | | Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds | 20100297250 | 20101125 | | 1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
... | | Process for producing perfluoroalkyne compound | 20100292516 | 20101118 | | A process for producing a perfluoroalkyne compound includes an addition reaction step of adding Cl2, Br2, or I2 to a compound shown by the formula (1) CH3C≡CR1 to obtain a compound shown by the formula (2) CH3CX2CX2R1, a fluorination reaction step of reacting the compound shown by the formula (2) with fluorine gas to obtain a compound shown by the formula (3) CF3CX2CX2R2, and a dehalogenation reaction step of contacting the compound shown by the formula (3) with a metal or an organometallic compound to obtain a perfluoroalkyne compound shown by the formula (4) CF3C≡CR2. According to the present invention, a perfluoroalkyne compound can be produced at high productivity and high yield using starting raw materials which are environmentally friendly and industrially available. In the above... | | Ruthenium-catalyzed cycloaddition of alkynes and organic azides | 20100286405 | 20101111 | | A convenient process for the regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles and 1,4,5-trisubstituted 1,2,3-triazoles from organic azides and alkynes employs catalytic ruthenium.
... | | Alkoxycrylene/metal oxide photostabilized photoactive compositions and methods | 20100283015 | 20101111 | | wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and... | | Energy transfer dyes with enhanced fluorescence | 20100280246 | 20101104 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Intramolecular azide-alkyne cycloaddition | 20100280238 | 20101104 | | The Huisgen 1,3-dipolar cycloaddition is a ‘click’ reaction that results from the ligation of azides and alkynes to give a triazole moiety. This reaction has been shown to be effective in the formation of a variety of macrocyclic rings. A key point of interest is the regioselectivity and specificity of the cycloaddition. Disclosed herein are specific, selective, and high-yielding methods of azide-alkyne macrocyclization to form 1,4- and 1,5-triazoles and libraries thereof.
... | | Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine | 20100274016 | 20101028 | | This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.
... | | Synthesis of 4/5-pyrimidinylimidazoles via sequential functionalization of 2,4-dichloropyrimidine | 20100274015 | 20101028 | | This invention relates to methods of making pyrimidinyl-substituted imidazole compounds by sequential substitution of the 4- and 2-chloro groups of 2,4-dichloropyrimidine, nucleophilic substitution to form pyrimidinylalkyne derivatives, oxidation to the corresponding 1,2-diketones, and cyclocondensation reactions.
... | | Methods of preparing, optionally supported, ordered intermetallic palladium gallium compounds, the compounds, as such, and their use in catalysis | 20100261939 | 20101014 | | The present invention pertains to methods of preparing optionally supported, ordered intermetallic palladium gallium compounds, and the corresponding, optionally supported, intermetallic palladium gallium compounds obtainable by these methods. The present invention also pertains to the use of the optionally supported ordered intermetallic palladium gallium compounds as catalysts, such as in selective hydrogenations of alkynes, in particular ethyne, to give the corresponding alkenes. The optionally supported, ordered intermetallic palladium gallium compounds were found to be highly active and selective catalysts in the above hydrogenation reactions.
... | | Process for the palladium-catalyzed coupling of terminal alkynes with aryl tosylates | 20100261910 | 20101014 | | wherein R1; R2; R3; R4; R5; J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process for aryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional aryl-1-alkynes of the formula I.
... | | Process for the palladium-catalyzed coupling of terminal alkynes with heteroaryl tosylates and heteroaryl benzenesulfonates | 20100261900 | 20101014 | | wherein D, J and W have the meanings indicated in the claims. The present invention provides an efficient and general palladium-catalyzed coupling process of heteroaryl tosylates with terminal alkynes to a wide variety of substituted, multifunctional heteroaryl-1-alkynes of the formula I.
... | | Microporous polymers, methods for the preparation thereof, and uses thereof | 20100240781 | 20100923 | | A method for preparing a conjugated microporous polymer comprises the coupling of an alkynyl aryl monomer having a plurality of terminal alkyne groups with an iodo- or bromo-aryl monomer having a plurality of halogen atoms in the presence of a palladium (0) catalyst. The conjugated microporous polymer comprises nodes comprising at least one aryl unit and struts comprising at least one alkyne unit and at least one aryl unit, wherein a node is bonded from its aryl unit or units to at least two struts via alkyne units. Such polymers are useful in numerous areas such as separations, controlled release, gas storage and supports for catalysts.
... | | Process for the preparation of keto intermediates | 20100228034 | 20100909 | | Process for the preparation of 4-[1-oxo-4-[4-(hydroxyphenylmethyl)-1-piperidinyl]butyl]-α,α-dimethylbenzenacetic acid, which is an intermediate useful in the preparation of fexofenadine, by hydrating asymmetric alkynes.
... | | Cyclopropenones and the photochemical generation of cyclic alkynes therefrom | 20100210854 | 20100819 | | Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a “click” reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.
... | | Piperidine/piperazine derivatives | 20100210618 | 20100819 | | The invention relates to a DGAT inhibitor of formula (I), including any stereochemically isomeric form thereof, wherein A represents CH or N; the dotted line represents an optional bond in case A represents a carbon atom; X represents —O—C(═O)—; —C(═O)—C(═O)—; —NRX—C(═O)—; —Z—C(═O)—; —Z—NRX—C(═O)—; —C(═O)—Z—; —NRX—C(═O)—Z—; —C(═S)—; —NRX—C(═S)—; —Z—C(═S)—; —Z—NRX—C(═S)—; —C(═S)—Z—; —NRX—C(═S)—Z—; Z represents a bivalent radical selected from C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl; wherein each of said C1-6alkanediyl, C2-6alkenediyl or C2-6alkynediyl may optionally be substituted; and wherein two hydrogen atoms attached to the same carbon atom in C1-6alkanediyl may optionally be replaced by C1-6alkanediyl; Y represents —C(═O)—NRX— or —NRX—C(═O)—; R1 represents adamantanyl, C3-6cycloalkyl; aryl1 or Het1; R2 represents C3-6cycloalkyl, phenyl, naphtalenyl, 2,3-dihydro-1,4-benzodioxinyl, 1,3-benzodioxolyl, 2,3-dihydrobenzofuranyl or a 6-membered aromatic heterocycle containing 1 or 2 N atoms, wherein said... | | High voltage electrolyte (muldoon, allred) | 20100209780 | 20100819 | | A battery that includes a cathode, anode and an electrolytic solution containing an organic electrolyte solvent including a compound of the formula: R1—CO—NR2—OR3 wherein R1 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives and perfluorinated analogues; R2 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives; R3 is selected from alkanes, alkenes, alkynes, aryls and their substituted derivatives wherein the electrolyte is stable at voltages of greater than 4.0 volts.
... | | Process to produce a methane rich gas mixture from gasification derived sulphur containing synthesis gases | 20100205863 | 20100819 | | A method for converting a raw gas into a methane-rich and/or hydrogen-rich gas includes the following steps: a) providing the raw gas stemming from a coal and/or biomass gasification process, thereby the raw gas comprising beside a methane and hydrogen content carbon monoxide, carbon dioxide, alkanes, alkenes, alkynes, tar, especially benzole and naphthalene, COS, hydrogen sulfide and organic sulfur compounds, especially thiophenes; thereby the ratio of hydrogen to carbon monoxide ranges from 0.3 to 4; b) bringing this raw gas into contact with a catalyst in a fluidized bed reactor at temperatures above 200° C. and at pressures equal or greater than 1 bar in order to convert the raw gas into a first product gas, thereby simultaneously converting organic sulfur components into hydrogen sulfide, reform... | | Protein repelling silicon and germanium surfaces | 20100200963 | 20100812 | | The present invention relates to a process for preparing a functionalized Si/Ge-surface, wherein an unfunctionalised Si/Ge-surface is contacted in the presence of ultraviolet radiation with a C2-C50 alkene and/or a C2-C50 alkyne, and/or alkyne being optionally substituted and/or being optionally interrupted by one or more heteroatoms. The present invention further relates to articles or substrates comprising the functionalized Si/Ge-surface and the use of the functionalised Si/Ge-surface to prevent or to reduce adsorption of a biomolecule to an article or a substrate.
... | | Ligands for copper-catalyzed azide-alkyne cycloaddition reactions | 20100197871 | 20100805 | | Ligands useful for promoting copper-catalyzed azide-alkyne cycloaddition reactions comprise a compound represented by structural Formula (I) as described in the specification, wherein in Formula (I) Z1 is a nitrogen-containing heterocyclic group or a group represented by the formula: Y1—(CH2)c—Y2—(CH2)d—Y3—CH2—N(CH2Z4)(CH2Z5), where Y1 is -E1-C(O)O—, -E1-C(O)NH—, -E1-, or a covalent bond; Y2 is a covalent bond, —CH═CH—, or a 1,4-(1,2,3-triazolyl) group; Y3 is —OC(O)-E2-, —NHC(O)-E2-, -E2-, or a covalent bond; each of E1 and E2 is a benzimidazolyl group attached at the 1 and 2 positions; each of c and d is independently 1, 2, 3, 4, or 5; each of Z2, Z3, Z4 and Z5 is a nitrogen-containing heterocyclic group including a substituent X1 and optionally including a substituent (CH2)n—R1, and Y1, Y2, Y3, X1, R1, c,... | | M13 bacteriophage as a chemoaddressable nanoparticle for biological and medical applications | 20100190233 | 20100729 | | Reactive and modified M13 bacteriophages, and methods of making and using the same, are generally provided. The reactive M13 bacteriophage can include a alkyne functional group covalently attached to the M13 bacteriophage. The modified M13 bacteriophage can include a substituent covalently attached to the M13 bacteriophage via a 1,2,3-triazole linkage. Dual-modified M13 bacteriophages are also generally provided, and can include a cancer-targeting substituent covalently attached to the M13 bacteriophage and a fluorescent group covalently attached to the M13 bacteriophage. The modified M13 bacteriophages can not only be employed as a fluorescent probe for cancer imaging, but also can be used as biomaterials for cell alignment and scaffolding.
... | | Method and apparatus for producing propylene | 20100179365 | 20100715 | | A method for producing propylene including: transferring a feed gas including dimethyl ether and/or methanol and C4 and/or C5 olefins into a reactor, and reacting the feed gas in the presence of a catalyst, the feed gas prior to transferring into the reactor having a (supplied C4 and/or C5 olefins)/(supplied dimethyl ether and methanol) ratio of 0.25 to 7.5, in terms of the molar ratio based on the number of carbon atoms, and the feed gas being contacted with the catalyst at 350° C. to 600° C.; and an apparatus for producing propylene including: a hydrogenation reactor in which alkynes and/or dienes contained in C4 and/or C5 hydrocarbons is partially hydrogenated to be converted into an olefin having one double bond; a reactor in which C4... | | Process for production of substituted benzene | 20100168441 | 20100701 | | wherein R1 and R3 independently represent a linear or cyclic C1-C20 aliphatic hydrocarbon group or the like; R2 represents a hydrogen atom or the like; X represents a hydrogen atom, O or the like; and Y represents O, S or the like.
... | | Production of telechelic compounds by metathesis depolymerization | 20100168352 | 20100701 | | Telechelic unsaturated polymers suitable for conversion to functionalized derivatives such as polyols are prepared by metathesis of an unsaturated copolymer formed by addition polymerization of ethylene, a diene or alkyne and, optionally, one or more C3.20 α-olefins.
... | | Heteroaryl-substituted alkyne compounds and method of use | 20100160283 | 20100624 | | wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
... | | Method for producing vinyl esters of carboxylic acids | 20100152481 | 20100617 | | The process gives rise to the desired vinyl esters with a high yield.
... | | Nonlinear optical material composition and method of manufacture | 20100152338 | 20100617 | | Embodiments of the present disclosure provide non-linear optical compounds and compositions comprising a silole-derivative. In an embodiment, the silole derivative comprises a chromophore including a structure represented by Formula (A): wherein each Of R1, R2, R3, and R4 are independently selected from the group consisting of a hydrogen atom, a C1-10 linear alkyl group, a C1-10 branched alkyl group, a C5-10 aryl group, a heteroaryl group, an alkene group, an alkyne group, a cycloalkene, a cycloalkyne, and a substituted or unsubstituted heteroatom and X1 and X2 are each independently selected from the group consisting of O, S, and Se. Compositions formed from embodiments of the silole derivative may be used in non-linear optical devices, particularly passive and active optical waveguides.
... | | New silylsubstituted 1,2-alkynes and synthesis of silylsubstituted 1,2-alkynes | 20090318726 | 20091224 | | New silylsubstituted 1,2-alkynes of the general formula 1 and a new way of synthesis of new and already known silylsubstituted 1,2-alkynes of the general formula 1. The unknown silylsubstituted 1,2-alkynes of general formula 1, in which R1 stands for trialkoxysilyl group, dimethyl(trimethylsiloxy)silyl group, phenyldimethylsilyl group, methylbis(trimethylsiloxy)silyl group; R2 stands for alkyl, trialkylsilyl group with all alkyl substituents the same, 1-trimethylsiloxycycloalkyl group, cycloalkyl group, tertbutyl group, 1-trimethylsiloxyalkyl group, tertbutyldimethylsilyl group or 1-alkoxyalkyl group. The subject matter of the invention is a new way of synthesis of new and already known silylsubstituted 1,2-alkynes of general formula 1, in which R1 and R2 specified above, in which an alkene of general formula 2, with R1 specified above is subjected to silylative coupling with a terminal alkynes of the general... | | Methods of dispersing carbon nanotubes | 20090317660 | 20091224 | | A method is described for preparing carbon nanotube dispersions in organic solvents such as chloroform and methyl ethyl ketone. Structures resulting from organic dispersions are also disclosed. The dispersing agents used in this method comprise long chain hydrocarbons, halogen-substituted hydrocarbons, fluorocarbons, or a mixture of hydrocarbons, halogen-substituted hydrocarbons, and fluorocarbons; wherein the hydrocarbons, halogen-substituted hydrocarbons and fluorocarbons have from 6 to 40 carbons in a chain, at least one alkene or alkyne moiety, and at least one pendant carboxylic acid, phosphonic acid, and/or sulfonic acid group or an ester of these acids.
... | | Photochromic compounds | 20090309076 | 20091217 | | A photochromic compound is provided, which may be a pyran, an oxazine, or a fulgide. The photochromic compound has at least one substituent Q attached thereto, each Q independently being —N3, —CN, —COOR′, —CCR′, —C(R′)C(R′)R′, —OCOR′, —OCOOR′, —SR′, —OSO2R′″, and/or —CON(R′)R′, wherein each R′ is hydrogen, an unsubstituted or substituted alkyl group having from 1 to 18 carbon atoms; an unsubstituted or substituted aryl group, an unsubstituted or substituted alkene or alkyne group having from 2 to 18 carbon atoms, wherein the substituents are halo or hydroxyl and R′″ is —CF3 or a perfluorinated alkyl group having from 2 to 18 carbon atoms The number, locations and nature of the constituents Q are dependent upon the structure of the photochromic compound.
... | | Highly energy-producing compound | 20090299106 | 20091203 | | A highly energy-producing compound which can be used, for example, as an explosive, propellant, oxidant and the like, and which includes an alkyne unit in which at least one hydrogen atom has been replaced by a trinitromethyl —C(NO2)3 group.
... | | Method of biomolecule immobilization on polymers using click-type chemistry | 20090297609 | 20091203 | | The present invention provides a method for the covalent immobilization of biomolecules on polymers for delivery of the biomolecules, which has the advantage of being simple, highly efficient, environmentally friendly and free of side products relative to traditional immobilization techniques. The invention provides a modified micro/nanoparticle system, which uses a functionalized polymer formed into micro or nanoparticles to bind a molecule to the particles using uses facile chemistry, the Diels-Alder cycloaddition between a diene and a dienophile with the polymer being functionalized with one of them and the molecule with the other, or the Huisgen 1,3-dipolar cycloaddition between a terminal alkyne and an azide to bind the molecule to the particle. The molecules and/or other therapeutic agents may be encapsulated within the polymer particles for intravenous... | | Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions | 20090291141 | 20091126 | | wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and... | | Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions | 20090291055 | 20091126 | | wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and... | | Method of quenching electronic excitation of chromophore-containing organic molecules in phtoactive compositions | 20090291054 | 20091126 | | wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and... | | Etching gas for removing organic layers | 20090283714 | 20091119 | | An etching gas for removing organic layer is disclosed. The etching gas of the present invention preferably includes two compositions. The first composition of the etching gas includes hydrocarbon, halogen or halogen compound, oxygen gas, hydrogen gas, nitrogen has, and inert gas, in which the hydrocarbon comprises an alkene. The second composition of the etching gas includes hydrocarbon, halogen or halogen compound, oxygen gas, hydrogen gas, nitrogen gas, and inert gas, in which the hydrocarbon comprises an alkyne. The etching gas of the present invention may also include hydrofluorocarbon compounds, hydrogen chloride, and hydrogen bromide to improve the performance of the etching process.
... | | Vapor phase methods for forming electrodes in phase change memory devices | 20090275198 | 20091105 | | A method for forming electrode materials uniformly and conformally within openings having small dimensions, including sublithographic dimensions, or high aspect ratios. The method includes the steps of providing an insulator layer having an opening formed therein, and forming a conformal conductive or semiresistive material over and within the opening. The method is a CVD or ALD process for forming metal nitride, metal aluminum nitride, and metal silicon nitride electrode compositions. The methods utilize metal precursors containing one or more ligands selected from alkyl, allyl, alkene, alkyne, acyl, amide, amine, immine, imide, azide, hydrazine, silyl, alkylsilyl, silylamine, chelating, hydride, cyclic, carbocyclic, cyclopentadienyl, phosphine, carbonyl, or halide. Suitable precursors include monometallic precursors having the general formula MRn, where M is a metal, R designates a ligand as indicated... | | Vapor phase methods for forming electrodes in phase change memory devices | 20090275198 | 20091105 | | A method for forming electrode materials uniformly and conformally within openings having small dimensions, including sublithographic dimensions, or high aspect ratios. The method includes the steps of providing an insulator layer having an opening formed therein, and forming a conformal conductive or semiresistive material over and within the opening. The method is a CVD or ALD process for forming metal nitride, metal aluminum nitride, and metal silicon nitride electrode compositions. The methods utilize metal precursors containing one or more ligands selected from alkyl, allyl, alkene, alkyne, acyl, amide, amine, immine, imide, azide, hydrazine, silyl, alkylsilyl, silylamine, chelating, hydride, cyclic, carbocyclic, cyclopentadienyl, phosphine, carbonyl, or halide. Suitable precursors include monometallic precursors having the general formula MRn, where M is a metal, R designates a ligand as indicated... | | Device to separate olefins from paraffins and to purify olefins and use thereof | 20090270665 | 20091029 | | The present invention discloses a device, which uses membranes, capable of separating olefins from paraffins. The device (1) considers an ultramicroporous ceramic membrane module, zeolite or silicate based, containing a fixed carrier of copper I or silver ions (#-complexant ions) inserted by ion exchange, or as a monolayer of CuCl, AgNO3, Cu or Ag+ (2). Olefins have higher diffusivity and affinity to the membrane than the remaining species, therefore the bicomponent permeation selectivity becomes reinforced when compared to the ideal permeation selectivity. The purification of olefins by removal of dienes and/or alkynes, is accomplished with a zeolite membrane functionalized with Ag+ and having a specific catalyst in the permeate side (4), e.g. palladium nanoparticulated, for catalyzing the hydrogenation of the permeating dienes and alkynes to the... | | Device to separate olefins from paraffins and to purify olefins and use thereof | 20090270665 | 20091029 | | The present invention discloses a device, which uses membranes, capable of separating olefins from paraffins. The device (1) considers an ultramicroporous ceramic membrane module, zeolite or silicate based, containing a fixed carrier of copper I or silver ions (#-complexant ions) inserted by ion exchange, or as a monolayer of CuCl, AgNO3, Cu or Ag+ (2). Olefins have higher diffusivity and affinity to the membrane than the remaining species, therefore the bicomponent permeation selectivity becomes reinforced when compared to the ideal permeation selectivity. The purification of olefins by removal of dienes and/or alkynes, is accomplished with a zeolite membrane functionalized with Ag+ and having a specific catalyst in the permeate side (4), e.g. palladium nanoparticulated, for catalyzing the hydrogenation of the permeating dienes and alkynes to the... | | Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions | 20090246157 | 20091001 | | wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and... | | Bioadhesive composition formed using click chemistry | 20090247651 | 20091001 | | The present disclosure provides compositions which may be utilized as adhesives or sealants in medical and surgical applications. The compositions may, in embodiments, be formed from the cycloaddition reaction of a first component possessing at least one azide group with a second component possessing at least one alkyne group.
... | | Construction of a multivalent scfv through alkyne-azide 1,3-dipolar cycloaddition | 20090234105 | 20090917 | | The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.
... | | Oligomeric derivatives of spirobifluorene, their preparation and use | 20090234164 | 20090917 | | R1: is the same or different and independently represents H or an aliphatic or aromatic hydrocarbon rest with 1 to 20 C-atoms.
... | | Process of butadiene-1, 3 extraction | 20090234172 | 20090917 | | This invention presents a process of butadiene-1,3 extraction. The process consists of the procedure of 1st extractive fractionation, 2nd extractive fractionation, distillation and alkyne fractionation. This invention can improve the yield and capacity of butadiene extraction unit by adding an alkyne fractionator to the existing butadiene extraction unit and appropriately adjusting the process condition of 1st and 2nd extractive fractionators. This invention can decrease the energy and material consumption per unit of butadiene-1,3, which greatly improved the economic profit. The investment on various scales of butadiene extraction units for adding alkyne fractionator is almost same. Further more, the profit is in direct proportion with the scale of a plant and output is in several to some dozens of folds to investment. After the implementation of this... | | Construction of a multivalent scfv through alkyne-azide 1,3-dipolar cycloaddition | 20090234105 | 20090917 | | The present invention provides for a practical, universal and efficient method to ligate two large macromolecules (e.g., proteins) using the alkyne-azide 1,3-dipolar cycloaddition reaction to produce a conjugated macromolecule, such as a multivalent scFv. The present invention also provides for conjugate macromolecules comprising a plurality of macromolecule components cross-linked through at least one linking group comprising at least one 1,2,3-triazole moiety, wherein at least 50 percent of the macromolecule components in the conjugate macromolecule has only one site available for cross-linking.
... | | Oligomeric derivatives of spirobifluorene, their preparation and use | 20090234164 | 20090917 | | R1: is the same or different and independently represents H or an aliphatic or aromatic hydrocarbon rest with 1 to 20 C-atoms.
... | | Process of butadiene-1, 3 extraction | 20090234172 | 20090917 | | This invention presents a process of butadiene-1,3 extraction. The process consists of the procedure of 1st extractive fractionation, 2nd extractive fractionation, distillation and alkyne fractionation. This invention can improve the yield and capacity of butadiene extraction unit by adding an alkyne fractionator to the existing butadiene extraction unit and appropriately adjusting the process condition of 1st and 2nd extractive fractionators. This invention can decrease the energy and material consumption per unit of butadiene-1,3, which greatly improved the economic profit. The investment on various scales of butadiene extraction units for adding alkyne fractionator is almost same. Further more, the profit is in direct proportion with the scale of a plant and output is in several to some dozens of folds to investment. After the implementation of this... | | Click chemistry surface functionalization for resonant micro-cavity sensors | 20090214755 | 20090827 | | Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
... | | Click chemistry surface functionalization for resonant micro-cavity sensors | 20090214755 | 20090827 | | Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
... | | Click chemistry surface functionalization for resonant micro-cavity sensors | 20090214755 | 20090827 | | Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
... | | Click chemistry surface functionalization for resonant micro-cavity sensors | 20090214755 | 20090827 | | Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
... | | Click chemistry surface functionalization for resonant micro-cavity sensors | 20090214755 | 20090827 | | Micro-cavity resonant sensors have outer surfaces that are functionalized using click chemistry, e.g., involving a cycloaddition reaction of an alkyne functional group and an azide functional group. A first polymer linking element binds to an outer surface of the micro-cavity and has an azide functional group, which bonds to an alkyne functional group of a second polymer linking element as a result of a cycloaddition reaction. A functionalization element such as an antibody, antigen or protein for sensing a target molecule is bound to the second linking element.
... | | Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions | 20090208435 | 20090820 | | wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and... | | Method of quenching electronic excitation of chromophore-containing organic molecules in photoactive compositions | 20090208435 | 20090820 | | wherein A and B are the same or different and are selected from the group consisting of oxygen, amino and sulfur; R1 and R3 are the same or different and are selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2-C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne, aryl, substituted aryl, heteroaryl, heterocycloalkyl, substituted heteroaryl and substituted heterocycloalkyl; R2 is selected from the group consisting of C1-C30 alkyl, C2-C30 alkylene, C2C30 alkyne, C3-C8 cycloalkyl, C1-C30 substituted alkyl, C3-C8 substituted cycloalkyl, C1-C30 substituted alkylene, C2-C30 substituted alkyne; R4, R5, R6 and R7 are the same or different and are selected from the group consisting of C1-C30 alkoxy straight chin on branched and a, b, c and d are each either 0 or 1, and... | | Compositions and methods for coupling a plurality of compounds to a scaffold | 20090181402 | 20090716 | | Compositions and methods are provided for coupling a plurality of compounds to a scaffold. Compositions and methods are further provided for catalyzing a reaction between at least one terminal alkyne moiety and at least one azide moiety, wherein one moiety is attached to the compound and the other moiety is attached to the scaffold, forming at least one triazole thereby.
... | | Method for synthesizing furanosteroids | 20090143346 | 20090604 | | The present invention is a method for synthesizing furanosteroids. The method involves intramolecular Diels-Alder/retro-Diels-Alder reaction and tautomerization of a functionalized alkyne oxazole to produce a furo[2,3-b]phenol derivative which is elaborated by intermolecular and intramolecular condensations to generate ring-A of the furanosteroid. Furanosteroids and pharmaceutical compositions containing the same are also provided.
... | | Process for preparing vinyl carboxylates | 20080308765 | 20081218 | | The process gives the desired vinyl esters with high yield.
... | | Polymeric materials via click chemistry | 20080311412 | 20081218 | | Adhesive polymers are formed when polyvalent azides and alkynes are assembled into crosslinked polymer networks by copper-catalyzed 1,3-dipolar cycloaddition. The condensation polymerization is efficiently promoted by Cu ions either leached from the metal surface or added to the monomer mixture, and strong interactions with metal surfaces are provided by the multiple triazole binding elements produced. The adhesive polymers may be formed either as adhesive polymer coatings or as adhesive polymer cement.
... | | Stabilizers for use in nvp synthesis | 20080312432 | 20081218 | | A process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst, wherein the reaction is carried out in the presence of at least one stabilizer, and the use of stabilizers for increasing the selectivity in a process for preparing N-alkenyl compounds by reacting the corresponding NH compounds with alkynes in the liquid phase in the presence of a catalyst.
... | | Process for liquid phase hydrogenation | 20080300437 | 20081204 | | A process and catalyst for the liquid phase selective hydrogenation of alkynes to alkenes with high selectivity to alkenes relative to alkanes, high alkyne conversion, and sustained catalytic activity comprising a reactant comprising an alkyne and a non-hydrocarbon solvent/absorbent, contacting the reactant stream with a hydrogen-containing stream in the presence of a supported, promoted, Group VIII catalyst, removing the solvent/absorbent, and recovering the alkene product.
... | | Self-assembled monolayer for tuning the work function of metal electrodes | 20080290783 | 20081127 | | The present invention discloses a self-assembled monolayer with a general formula G1-R-G2, wherein G1 is SH. R of the mentioned general formula comprises one or any combination selected from the group consisting of the following: unsubstituted linear, branched, or cyclic alkyl moiety; single or multi-substituted linear, branched, or cyclic alkyl moiety with substituent selected from the group consisting of alkene and alkyne; aromatic group; multiple fused ring group; and multiple fused ring group with heteroatoms. G2 is an electron-withdrawing group.
... | | Azonafide derivatives, methods for their production and pharmaceutical compositions therefrom | 20080292585 | 20081127 | | Azonafide derivatives are obtained by reacting azonafide with aldehydes, acyl halides, thioacyl halides, monoisocyanates, isothiocyanates, sulfonyl halides, monohalogenoalkanes, monohalogenoalkenes or monohalogenoalkynes, and are useful as active ingredients of pharmaceutical compositions for the prevention and treatment of cell proliferative disorders, in particular several forms of Cancer.
... | | Multicoordinated metal complexes for use in metathesis reactions | 20080293905 | 20081127 | | Improved catalysts useful in alkyne or olefin metathesis are made by bringing into contact a multi-coordinated metal complex comprising a multidentate Schiff base ligand, and one or more other ligands, with a selected activating compound under conditions such that at least partial cleavage of a bond between the metal and the multidentate Schiff base ligand of said metal complex occurs.
... | | Fabrication method of size-controlled, spatially distributed nanostructures by atomic layer deposition | 20080274282 | 20081106 | | A method of growing spatially-separated and size-controlled particles on substrate surfaces is provided. The method utilizes chemical modification of the substrate surface, an atomic layer deposition (ALD) system, providing a modified layer to the substrate surface and providing an ALD material for nanoparticle deposition. The method induces a Volmer-Weber growth method, where islands of the nanoparticles are formed on the surface. The modified layer controls a number of nucleation sites on the surface, where controlling the number of ALD cycles limits an amount of deposited the material for discrete the nanoparticles. The modified layer can include self-assembled monolayers, modified hydrophobicity of the surface, H-terminated surfaces, and varying functional groups within the modified layer, where thermally attached alkenes, photochemically attached alkenes, thermally attached alkynes or photochemically attached... | | Targeted imaging and/or therapy using the [3+2] azide-alkyne cycloaddition | 20080267878 | 20081030 | | The use of a selective chemical and bioorthogonal reaction providing a covalent ligation such as the [3+2] cycloaddition, in targeted molecular imaging and therapy is presented, more specifically with interesting applications for pre-targeted imaging or therapy. Current pre-targeted imaging is hampered by the fact that it relies solely on natural/biological targeting constructs (biotin/streptavidin). Size considerations and limitations associated with their endogenous nature severely limit the number of applications. The present invention describes how the use of an abiotic, bio-orthogonal reaction which forms a stable adduct under physiological conditions, by way of a small or undetectable bond, can overcome these limitations.
... | | Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells | 20080268468 | 20081030 | | The present disclosure relates to a method for metabolic oligosaccharide engineering that incorporates derivatized alkyne-bearing sugar analogs as “tags” into cellular glycoconjugates. The disclosed method incorporates alkynyl derivatized Fuc and alkynyl derivatized ManNAc sugars into a cellular glycoconjugate. A chemical probe comprising an azide group and a visual probe or a fluorogenic probe is used to label the alkyne-derivatized sugar-tagged glycoconjugate. In one aspect, the chemical probe binds covalently to the alkynyl group by Cu(I)-catalyzed [3+2] azide-alkyne cycloaddition and is visualized at the cell surface, intracellularly, or in a cellular extract. The labeled glycoconjugate is capable of detection by flow cytometry, SDS-PAGE, Western blot, ELISA or confocal microscopy, and mass spectrometry.
... | | Methods of labeling polynucleotides with energy transfer dyes | 20080268509 | 20081030 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Novel catalyst | 20080269425 | 20081030 | | The present invention is directed to provide a catalyst for reduction, which is capable of reducing even mono-substituted alkynes to alkenes and does not require the coexistence (combined use) of a toxic compound, and a method for reduction from alkynes to alkenes using the catalyst; and relates to a palladium-supported polyethyleneimine compound obtained by contacting a polyethyleneimine, a palladium compound and hydrogen gas in an oxygen-free state, a method for producing the above palladium-supported polethyleneimine compound, a catalyst for reduction comprising the above palladium-supported polyethyleneimine compound, and a method for reducing from alkynes to alkenes characterized by contacting an alkyne and hydrogen in the presence of a palladium-supported polyethyleneimine compound, which is obtained by reacting a polyethyleneimine, a palladium compound and hydrogen gas in an oxygen-tree... | | High selectivity process to make dihydrofluoroalkenes | 20080269532 | 20081030 | | Disclosed is a method for the synthesis of fluorinated alkenes comprising contacting a fluorinated alkyne of the formula R1 C≡C R2, wherein R1 and R2 are independently selected from CF3, C2F5, C3F7, and C4F9, in a pressure vessel, with a Lindlar catalyst, with substantially one molar equivalent of hydrogen, to make the corresponding cis-alkene of formula R1 C≡C R2 with high selectivity, wherein said hydrogen is added in portions over a period of time, so as to produce an initial pressure in the pressure in the vessel of no more than about 100 psi.
... | | Gas odorant | 20080256847 | 20081023 | | wherein R1 is methoxy or ethoxy; and R2 is hydrogen or methyl, to a process of odorizing gas and to fuel gas comprising it.
... | | Cyclosporin alkyne analogues and their pharmaceutical uses | 20080249002 | 20081009 | | with X, R0, R1, and R2 defined herein.
... | | Glycoproteomic probes for fluorescent imaging of fucosylated glycans in vivo | 20080241856 | 20081002 | | The disclosure provides a method of labeling of cellular glycans bearing azide groups via a fluorescent labeling technique based on Cu(I)-catalyzed [3+2]cycloaddition (click activation) of a probe comprising an alkynyl group. The method entails generating a fluorescent probe from a nonfluorescent precursor, 4-ethynyl-N-ethyl-1,8-naphthalimide, by Cu(I)-catalyzed [3+2]cycloaddition of the alkyne group of the probe with an azido-modified sugar. The disclosure further provides a method of incorporating an azido-containing fucose analog into glycoconjugates via the fucose salvage pathway. The disclosure provides a method of fluorescent visualization of fucosylated cells by flow cytometry when cells treated with 6-azidofucose are labeled with the click-activated fluorogenic probe or biotinylated alkyne. A method of visualizing the intracellular localization of fucosylated glycoconjugates by fluorescence microscopy is also disclosed.
... | | Copper-catalysed ligation of azides and acetylenes | 20080214831 | 20080904 | | A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.
... | | Insitu removal of chelator from anionic polymerization reactions | 20080161455 | 20080703 | | A process for producing polymers having at least one high vinyl end segment is provided. The process comprises: (a) forming a living prepolymer high vinyl initiator with a vinyl content greater than about 45% using a vinyl modifier, (b) adding a R1R2R3aluminum or R1R2R3boron compound to nullify the effect of the vinyl modifier, and (c) initiating polymerization of diene monomers using said living prepolymer high vinyl initiator so as to form a polymer product with at least one high vinyl end segment, where R1, R2, and R3 are selected from the group consisting of C1-C12 alkyl, C2-C12 alkene, C2-C12 alkyne, phenyl, and alkyl-substituted phenyl, and may all be identical or may all be separately selected but cannot be H. The polymers having at least one high... | | Selective radiolabeling of biomolecules | 20080161537 | 20080703 | | Provided herein are methods for introducing fluorine atom onto a biomolecule comprising: (i) providing a linker comprising a thiol-reactive terminus and an azido/alkyne-reactive terminus; (ii) reacting the thiol-reactive terminus of the linker with a biomolecule comprising at least one thiol group or a reactive derivative thereof; and (iii) subsequently reacting the azido/alkyne-reactive terminus of the linker with a fluorine-substituted azide or alkyne respectively. Also provided are compositions and method of synthesis of bifunctional linkers and bioconjugates as well as radio-diagnostic agents comprising fluorine-labeled biomolecules.
... | | Novel cyclosporin alkynes and their utility as pharmaceutical agents | 20080153744 | 20080626 | | with X, Ro, and R1 defined herein.
... | | Gas for plasma reaction, process for producing the same, and use thereof | 20080139855 | 20080612 | | A gas for plasma reaction comprising a chainlike perfluoroalkyne having 5 or 6 carbon atoms, preferably perfluoro-2-pentyne. This plasma reaction gas is suitable for dry etching for formation of a fine pattern, for plasma CVD for formation of a thin film, and for plasma ashing. The plasma reaction gas is synthesized by contacting a dihydrofluoroalkane compound or a monohydrofluoroalkene compound with a basic compound.
... | | Gas odorant | 20080127555 | 20080605 | | The present invention refers to the use of C7 to C9 cycloalkynes as gas odorant, to a process of odorising gas and to fuel gas comprising it.
... | | Phenylalkynes | 20080103135 | 20080501 | | Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
... | | Triazoles as farnesyl transferase inhibitors | 20080103150 | 20080501 | | a prodrug, N-oxide, addition salt, quaternary amine or stereochemically isomeric form thereof, wherein L1 and L2 are R1—Y— wherein each (R1—Y)— substituent is defined independently of the other; Y is C1-4alkanediyl, C2-4alkenediyl, C2-4alkynediyl, C(═O), or a direct bond; R1 is hydrogen, cyano, aryl or a substituted or unsubstituted C1-14heterocycle; =Z1-Z2=Z3- represents a radical of formula ═N—N═CH— (a-1), ═N—CH═N— (a-2), ═CH—N═N— (a-3); X is SO2, (CH2), wherein n is 1 to 4, C(═O), C(═S), or a direct bond; R2 is aryl, C3-7cycloalkyl, C3-7cycloalkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted C1-14heterocycle, C3-7cycloalkyl, hydroxycarbonyl, C1-6alkyloxycarbonyl, hydroxyC1-6alkyl, hydroxyC1-6alkyloxy, hydroxyC1-6alkylthio and arylC1-6alkylthio, C1-12alkyl or C1-12alkyl substituted with one or more substituents independently selected from hydroxy, aryl, aryloxy, a substituted or unsubstituted... | | Phenylalkynes | 20080096876 | 20080424 | | Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
... | | Phenoxymethylalkyne inhibitors of lta4h for treating inflammation | 20080090839 | 20080417 | | is disclosed. In these compounds Q and Z are (CH2)1-10; in which one or two (CH2) may optionally be replaced by —O—, —NR1—, —SO—, —S(O)2—, —C(═O)— or —C═O(NH)—; Het is a 5-7 membered non-aromatic nitrogen heterocycle; and W is acyl, hydroxyl, carboxyl, amino, carboxamido, aminoacyl, —COOalkyl, —CHO, heterocyclyl, substituted aryl, or substituted heterocyclyl, or taken together ZW can be H or —COOalkyl. The compounds are useful for the treatment and prevention and prophylaxis of inflammatory diseases and disorders.
... | | Carbometallation of alkynes and improved synthesis of uniquinones | 20080086013 | 20080410 | | Methods for the carbometallation of alkynes are presented. Those are useful for the synthesis of CoQ10 and other ubiquinones as well as for the synthesis of ubiquinol analogs.
... | | Compounds, kits and methods for use in medical imaging | 20080075661 | 20080327 | | FDG alternatives are provided. They consist of a two component system comprising on the one hand a building block such as glucose linked to an azide, alkyne or phosphine and on the other hand a detectable label linked to an azide, alkyne or phosphine which is the counterpart of the group linked to glucose in a Staudinger ligation reaction or a [3+2] cycloaddition reaction. It is preferred that the glucose is linked to an azide group and the detectable label is linked to a phosphine or cycloalkyne group. The detectable label is preferably a PET radionuclide label such as 18F.
... | | Use of paullone derivatives for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells | 20080076756 | 20080327 | | The invention relates to paullone derivaties for the production of medicaments for the treatment of mucoviscidosis and diseases related to protein addressing errors in cells, said derivaties being of general formula (1): wherein X═C═O, C—S—CH3, C—S,—C—NHOH, Z═C or N, Y═with the adjacent ring, a phenyl or thiazolyl group, the ring(s) of said derivaties being optionally substituted with one or more halogen atoms, hydroxy, alkylenehydroxy, alkynealkylenehydroxy, alkynehydroxycyclohexyl, alkyl, alkoxy, alkylenealkoxy, or alkylenecyano groups where the alkylene group is either saturated or unsaturated, the groups having a straight or branched chain with C1 to C18, said chain being optionally substituted with one or more hydroxy or amino groups, or one or more trifluoromethyl, —COM, —COOM, or —CH2COOM groups (where M═H, C1 to C18 straight or branched chain alkyl,... | | Process for production of polysubstituted cyclobutanes and polysubstituted cyclobutenes | 20080051598 | 20080228 | | The prior art required specialized substrates or reaction conditions to be used to manufacture polysubstituted cyclobutane compounds and polysubstituted cyclobutene compounds, and the method had poor generality. The type or quantity of the catalyst or solvent used was also problematic in the industrial manufacture of polysubstituted cyclobutane compounds. The present invention provides a method for manufacturing a polysubstituted cyclobutane compound with high stereoselectivity that has low environmental load (is ecologically advantageous) and is applicable to industrial manufacturing from the standpoint of operation, substrate generality, catalyst, solvent, and efficiency. A polysubstituted cyclobutane, a cyclobutene, and a bicyclo[4.2.0]octane compound can be manufactured efficiently, stereoselectively, and in an ecologically advantageous manner by causing a Brønsted acid to act on a mixture of an enol ether compound or 2-siloxydiene compound... | | Reactive coatings for regioselective surface modification | 20070272122 | 20071129 | | Reactive polymer coatings that undergo regioselective reactions with target biomolecules are provided. The polymers of the coatings are deposited via chemical vapor deposition and comprise one or more functional groups that exhibit regioselective bonding with a functional group or a target molecule. Such polymers include poly-xylylenes having functional groups such as alkynes or azides. The regioselective bonding of the reactive polymers provide stable immobilization of target molecules and/or ligands and can create biofunctional surfaces having a wide range of applications.
... | | Photocleavable fluorescent nucleotides for dna sequencing on chip constructed by site-specific coupling chemistry | 20070275387 | 20071129 | | This invention provides a method for determining the sequence of a DNA or an RNA, wherein (i) about 1000 or fewer copies of the DNA or RNA are bound to a solid substrate via 1,3-dipolar azide-alkyne cycloaddition chemistry and (ii) each copy of the DNA or RNA comprises a self-priming moiety.
... | | Substituted 8-aminoalkylthioxanthines, and their use as inhibitors of dipeptidyl peptidase iv | 20070265284 | 20071115 | | wherein the various R groups and substituents are comprised of a number of different (C1-C10)-alkyl, cycloalkyl, aryl, alkene, alkyne, etc. groups and derivatives thereof which are hereinafter more specifically defined for the treatment of metabolic disorders such as type-2 diabetes, hyperglycemia, arteriosclerotic diseases and the like
... | | Practical, cost-effective synthesis of ubiquinones | 20070260076 | 20071108 | | The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
... | | Use of cyclosporin alkyne analogues for preventing or treating viral-induced disorders | 20070232530 | 20071004 | | or a pharmaceutically acceptable salt thereof, with X, R0, and R1 defined herein, under conditions effective to prevent or treat the viral-induced disorder.
... | | Use of cyclosporin alkyne/alkene analogues for preventing or treating viral-induced disorders | 20070232531 | 20071004 | | or a pharmaceutically acceptable salt thereof, with X, R0, R1, and R2 defined herein, under conditions effective to prevent or treat the viral-induced disorder.
... | | Chemoselective fluorgenic molecular linkers and methods for their preparation and use | 20070224695 | 20070927 | | The present invention describes a bioconjugation strategy and compounds that are useful therein in which a fluorescent signal is produced when two molecular or supramolecular entities are linked by chemoselective combination of one linker having an azido or halide substituent group with another linker having a cyano or an alkyne substituent group. A kit is also provided.
... | | Method for reducing alkyne compuonds | 20070219383 | 20070920 | | in which the substituents R1 to R8 have independently of one another the meaning specified in the description, wherein the reducing agent comprises from 0.3 to 0.49 mol of at least one ammonium salt of the formula V per mol of zinc.
... | | Methods of labeling nucleic acids with energy transfer dyes | 20070212709 | 20070913 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Adhesive compositions containing cyclic siloxanes and methods for use thereof | 20070205399 | 20070906 | | The invention is based on the discovery that certain well-defined funtionalized cyclic siloxanes are useful as thermosetting resins for the electronic packaging industry. The functionalized cyclic siloxane compounds described herein can be cured in a variety of ways, depending on the polymerizable moiety incorporated into the compound. Invention cyclic siloxanes are readily prepared via hydrosilation of polyalkyl(hydro)cyclosiloxanes with appropriately functionalized alkenes and/or alkynes.
... | | Kits useful for sequencing nucleic acids | 20070207477 | 20070906 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Copper(i) formate complexes | 20070197810 | 20070823 | | with the exception of triphenylphosphinocopper(I) formate and 1,1,1-tris(diphenyl-phosphinomethyl)ethanecopper(I) formate; are decomposed for depositing metallic copper.
... | | Selective posttranslational modification of phage-displayed polypeptides | 20070178448 | 20070802 | | The invention relates to posttranslational modification of phage-displayed polypeptides. These displayed polypeptides comprise at least one unnatural amino acid, e.g., an aryl-azide amino acid such as p-azido-L-phenylalanine, or an alkynyl-amino acid such as para-propargyloxyphenylalanine, which are incorporated into the phage-displayed fusion polypeptide at a selected position by using an in vivo orthogonal translation system comprising a suitable orthogonal aminoacyl-tRNA synthetase and a suitable orthogonal tRNA species. These unnatural amino acids advantageously provide targets for posttranslational modifications such as azide-alkyne [3+2] cycloaddition reactions and Staudinger modifications.
... | | Regents labeled with energy transfer dyes | 20070161026 | 20070712 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Oligonucleotides and analogs labeled with energy transfer dyes | 20070161027 | 20070712 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Oligonucleotides and analogs labeled with energy transfer dyes | 20070154924 | 20070705 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Methods of analyzing polynucleotides employing energy transfer dyes | 20070154925 | 20070705 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Methods of analyzing polynucleotides employing energy transfer dyes | 20070154926 | 20070705 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers facilitate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Energy transfer dyes with enhanced fluorescence | 20070154927 | 20070705 | | Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R21Z1C(O)R22R28 where R21 is a C1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z1 is either NH, sulfur or oxygen, R22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R28 includes a functional group which... | | Novel proton exchange membranes using cycloaddition reaction between azide and alkyne containing components | 20070155953 | 20070705 | | A process for making an ion-conducting polymer comprises cross-linking polymers having functional groups such as alkyne groups and azide groups. An example ion-conducting polymer has cross-links including nitrogen-containing heterocycles formed by the reaction between the functional groups, such as 1,2,3-triazole groups formed by a cycloaddition reaction between alkyne and azide groups. The ion-conducting polymer may be used in an ion-electrolyte membrane. Examples include a proton-electrolyte membrane useful for fuel cells.
... | | Method of coating the surface of an inorganic substrate with an organic material and the product obtained | 20070148463 | 20070628 | | A method of coating the surface of an inorganic substrate of glass, silicon dioxide, ceramics or carbon, which method comprises a step of cleaning the surface of the substrate by subjecting the surface to a reducing gas plasma and forming a first layer on the substrate surface using a plasma enhanced polymerization process employing one or more monomers comprising monomers with a sufficient low molecular weight for them to be in their gaseous state in the gas plasma, selected from the group consisting of C1-C16 alkanes, C2-C16 alkenes, C2-C16 alkynes, styrene, aromatic monomers of styrene compounds, monomers of vinyl- and acrylate-compounds.
... | | Technology to improve yield and capacity of the butadiene extraction facility which uses c4 as feedstock supplied by ethylene plant | 20070149840 | 20070628 | | This technology aims to improve yield and throughput of butadiene extraction facility which uses C4 as feedstock supplied by ethylene plant. The key point of the technical solution is to properly broaden quality index of trans-butene-2 and cis-butene-2 in secondary rectification tower. In addition, an alkyne rectification tower is added to the extraction process. The main application is to improve the yield of butadiene extraction facility and its throughput. The major benefits are that butadiene yield is improved by 1% to 2% and the throughput is increased by 10%.
... | | Supported catalyst for the selective hydrogenation of alkynes and dienes | 20070142683 | 20070621 | | A catalyst for the selective hydrogenation of alkynes and dienes in C2-C5+-olefin mixtures is described. These catalysts contain (a) a metal of the tenth group of the Periodic Table, (b) a metal of the eleventh group of the Periodic Table and (c) if required, a compound of a metal of the first or second group of the Periodic Table, these metals being applied to a support which is selected from the group consisting of silica, titanium dioxide, zirconium oxides, spinels, zinc aluminates, zinc titanates or mixtures of these substances, and the metal of the eleventh group being distributed homogeneously over the cross section of the catalyst particle and the metal of the tenth group being present in the edge layer close to the surface of the... | | Aza nucleosides, preparation thereof and use as inhibitors of rna viral polymerases | 20070099942 | 20070503 | | R8 and R9 independently is H, NH2, OH, SH, F, Cl, Br, I, aryl, heterocycle, alkyl, alkene, alkyne, S-alkyl, S-aryl, S(O)-alkyl, SO2-alkyl, SO2NH2, SO2NH-alkyl, SO2NH-aryl, NH-alkyl, NH-aryl, N(alkyl)2, N(aryl)2, O-alkyl, O-aryl, O-heterocycle, NH-(CH2)n-aryl, NH—C(O)-alkyl, NH—C(O)-aryl are useful for inhibiting viral RNA polymerases and treating patients suffering from diseases caused by various RNA viruses.
... | | Phenylalkynes | 20070072837 | 20070329 | | Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
... | | Palladium-catalyzed carbon-carbon bond forming reactions | 20070066851 | 20070322 | | A novel palladium-mediated carbon-carbon bond forming reaction has been discovered using DNA-templated chemistry. The inventive reaction involves the palladium-mediated coupling of a terminal alkyne with an alkene to form an enone. A catalytic amount of palladium may be used in the reaction if an oxidant is present. The reactions is also compatible with a variety of organic solvent as well as aqueous solution. Both intermolecular and intramolecular reactions have been demonstrated. This novel carbon-carbon bond forming reaction is particularly useful in the synthesis of macrocycles. Kits, reagents, catalysts, solvents, oxidants, salts, acids, instructions, and other materials useful in the practice of the inventive reaction are also provided.
... | | Alkyne derivatives as tracers for metabotropic glutamate receptor binding | 20070060618 | 20070315 | | The present invention is directed to isotopically labeled alkyne derivative compounds, particularly 11C, 13C, 14C, 18F, 15O, 13N, 35S, 2H, and 3H labeled compounds. In particular, the present invention is directed to 11C, 13C, 14C, 18F, 15O, 13N, 35S, 2H, and 3H labeled heterocyclic alkynes and methods of their preparation. The present invention further includes a method of use of the 11C, 18F, 15O, or 13N labeled heterocyclic alkyne compounds as tracers in positron emission tomography (PET) imaging, particularly in the study of metabolic conditions in mammals, specifically conditions modulated by metabotropic glutamate receptors subtype 5 (mGluR5).
... | | Stabilization of organogels and hydrogels by azide-alkyne [3+2] cycloaddition | 20070060658 | 20070315 | | Self-assembled gels were modified by the installation of azide and alkyne groups on the gelator and reaction with complementary reagents by the catalyzed azide-alkyne cycloaddition reaction. This is the first example of the use of a “click” reaction in such a supramolecular environment, and a new strategy for tuning the properties of gelled materials.
... | | Multicoordinated metal complexes for use in metathesis reactions | 20070043188 | 20070222 | | Improved catalysts useful in alkyne or olefin metathesis are made by bringing into contact a multi-coordinated metal complex comprising a multidentate Schiff base ligand, and one or more other ligands, with a selected activating compound under conditions such that at least partial cleavage of a bond between the metal and the multidentate Schiff base ligand of said metal complex occurs.
... | | Method for pickling metallic surfaces by using alkoxylated alkynols | 20070034606 | 20070215 | | Process for pickling metallic surfaces by treating the metallic surface with a composition which comprises water, at least one acid, an alkyne alkoxylate and optionally further additives. In a preferred embodiment, the alkyne alkoxylate is used together with a complexing agent.
... | | Heterogeneous alkyne metathesis | 20060281938 | 20061214 | | The present invention provides heterogeneous organometallic catalysts for alkyne metathesis, including the metathesis of internal alkynes. Organometallic precursors are covalently bonded to the oxygen atoms of metal oxide supports to form catalysts having carbyne functionality. The heterogeneous catalysts provide improved turn-over frequencies at lower reaction temperatures than conventional catalysts.
... | | Stereoselective synthesis of (e)-vinylboronic esters via a zr mediated hydroboration of alkynes | 20060281943 | 20061214 | | There is herein provided a process for Zr-mediated hydroboration of alkynes which offers (E)-vinylboronic esters in high yield with stereoselectivity and regioselectivity.
... | | Patterned functionalized silicon surfaces | 20060270101 | 20061130 | | The present invention provides a method for preparing a silicon substrate and a silicon substrate having a silicon surface comprising a pattern of covalently bound monolayers. Each of the monolayers comprises an alkyne, wherein at least a portion of each monolayer is no more than about 5 molecules of the alkyne wide.
... | | Phenylalkynes | 20060258859 | 20061116 | | Substituted phenylalkynes of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
... | | Method for manufacturing isoxazole derivative or dihydroisoxazole derivative | 20060247288 | 20061102 | | (where R2 is a methyl or a phenyl).
... | | Heteroaryl-substituted alkyne compounds and method of use | 20060217380 | 20060928 | | wherein A1, A2, A3, A4, R1 and R2 are defined herein. Accordingly, the invention also comprises pharmaceutical compositions comprising the compounds of the invention, methods for the prophylaxis and treatment of kinase mediated diseases using the compounds and compositions of the invention, and intermediates and processes useful for the preparation of compounds of the invention.
... | | Nonaqueous electrolytic solution for lithium secondary battery and lithium secondary battery using the same | 20060177742 | 20060810 | | A non-aqueous electrolytic solution is advantageously used in preparation of a lithium secondary battery excellent in cycle characteristics. In the non-aqueous electrolytic solution for a lithium secondary battery, an electrolyte salt is dissolved in a non-aqueous solvent. The non-aqueous electrolytic solution further contains a vinylene carbonate compound in an amount of 0.01 to 10 wt. %, and an alkyne compound in an amount of 0.01 to 10 wt. %.
... | | Practical, cost-effective synthesis of ubiquinones | 20060167289 | 20060727 | | The present invention provides a convergent method for the synthesis of ubiquinones and ubiquinone analogues. Also provided are precursors of ubiquinones and their analogues that are useful in the methods of the invention. The invention further provides an improved method for the carboalumination of alkyne substrates.
... | | Multistage filtration systems | 20060151372 | 20060713 | | A multistage filtration system filtration apparatus for separating organic contaminants from an aqueous phase in which the contaminant is solubilized or emulsified. Two or more filtration stages are connected in series, each stage comprising a canister or other container having an inlet and an outlet for passing said liquid phase therethrough, the aqueous phase thereby passing through the series connected stages. A fluid-pervious media is provided at the interior of the canister or container in the flow path of the liquid phase proceeding between said inlet and outlet, the media being infused with an absorbtion composition comprising a homogeneous thermal reaction product of an oil component selected from the group consisting of glycerides, fatty acids, alkenes, and alkynes, with a methacrylate or acrylate polymer component. The... | | Novel proton exchange membranes using cycloaddition reaction between azide and alkyne containing components | 20060154129 | 20060713 | | A process for making an ion-conducting polymer comprises cross-linking polymers having functional groups such as alkyne groups and azide groups. An example ion-conducting polymer has cross-links including nitrogen-containing heterocycles formed by the reaction between the functional groups, such as 1,2,3-triazole groups formed by a cycloaddition reaction between alkyne and azide groups. The ion-conducting polymer may be used in an ion-electrolyte membrane. Examples include a proton-electrolyte membrane useful for fuel cells.
... | | Process for the selective hydrogenation of alkynes | 20060155154 | 20060713 | | A process for removal of acetylenic compounds from hydrocarbon streams in which a hydrocarbon feed having a target fraction which contains a first concentration of acetylenic compounds and olefins is contacted with a catalyst selective for the hydrogenation of acetylenic compounds in the presence of hydrogen and a solvent having a boiling point higher than the boiling point of the target fraction in a distillation reaction zone under conditions of temperature, pressure and hydrogen concentration favoring the hydrogenation of acetylenic compounds in which the target fraction is recovered as overheads having a second concentration of acetylenic compounds lower than said first concentration and the solvent is recovered as bottoms.
... | | Compositions and methods for modification of biomolecules | 20060110782 | 20060525 | | The present invention provides modified cycloalkyne compounds; and method of use of such compounds in modifying biomolecules. The present invention features a cycloaddition reaction that can be carried out under physiological conditions. In general, the invention involves reacting a modified cycloalkyne with an azide moiety on a target biomolecule, generating a covalently modified biomolecule. The selectivity of the reaction and its compatibility with aqueous environments provide for its application in vivo (e.g., on the cell surface or intracellularly) and in vitro (e.g., synthesis of peptides and other polymers, production of modified (e.g., labeled) amino acids).
... | | Amidine compounds | 20060111381 | 20060525 | | Amidine derivatives of opioids of the formula YN—X—(NH)n-C(═NR)—R′ in which YN is a morphine-like opioid radical; X is a direct bond, a substituted or unsubstituted, branched, straight-chained or cyclic alkylene having from 1 to 6 carbon atoms, optionally containing one or two heteroatoms in the alkyl chain, or an optionally substituted, branched or straight-chained alkenylene having from 4 to 10 carbon atoms; R and R′ are independently hydrogen, alkyl, substituted alkyl, alkene, substituted alkene, alkyne, substituted alkyne, aryl, substituted aryl, heterocycle, substituted hetercycle or cyano; and n is 0 when X is said direct bond, or n is 1 when X is said alkylene or alkenylene. The compounds are effective in treating pain, and have effect in the peripheral nervous system, with comparably less or no... | | Method for producing optically active amines | 20060100239 | 20060511 | | The present invention provides a method for producing optically active amines of formula (9) or (10): which comprises reacting an imine equivalent of formula (6): with an alkene of formula (7) or an alkyne of formula (8): in the presence of a chiral catalyst, which method does not require additional procedures such as introduction and removal of protecting groups and gives said amines with high purity and high operability. The optically active amines are useful as synthetic 15 intermediates for pharmaceuticals, agrochemicals, etc.
... | | Novel cyclosporin alkynes and their utility as pharmaceutical agents | 20060074015 | 20060406 | | with X, R0, and R1 defined herein.
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