Adverse Event

Adverse Event-related patent applications - as published by the U.S. Patent and Trademark Office (USPTO).

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Providing status of user devices during an adverse event
May 04, 2017 - N°20170127260

A method begins by an application server establishing information regarding a potentially adverse condition and determining group constraints for a group regarding the potentially adverse condition. The method continues with the application server selecting one or more user devices of a plurality of user devices affiliated with the group to produce selected user devices. The method continues with the application ...
Providing status of user devices during an adverse event
May 04, 2017 - N°20170127232

A method begins by a processing module identifying a geographic area of an adverse condition and identifying a user device of a plurality of user devices potentially associated with the identified geographic area. The method continues with the processing module issuing a safety notification to the user device, where the safety notification includes one or more of the identified geographic ...
Materials and methods for differential treatment of cancer
Serametrix Corporation
May 04, 2017 - N°20170121776

The present invention concerns differential therapeutic treatment of cancer patients based on prognostic antigen/antibody profiles used for predicting (prognosticating) a clinical response (efficacy) and/or adverse event to an immunotherapy for treatment of a malignancy in a subject, and for treating or delaying the onset or relapse of a malignancy in a subject.
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Prediction of adverse drug events
International Business Machines Corporation
April 27, 2017 - N°20170116390

Embodiments include method, systems and computer program products for predicting adverse drug events on a computational system. Aspects include receiving known drug data from drug databases and one or more of a candidate drug, a drug pair, and a candidate drug-patient pair. Aspects also include calculating an adverse event prediction rating representing a confidence level of an adverse drug event ...
Systems and methods for dynamically generated genomic decision support for individualized medical treatment
Aetna Inc.
April 27, 2017 - N°20170116379

Optimization of therapeutic outcomes is disclosed. By analyzing molecular genomic sequence data from an individual relative to a pre-defined knowledge base as well as dynamically generated analyses from comparison to a set of other individuals and molecular genomic sequence data of those other individuals along with their therapeutic history and clinical outcome, medication selection for optimum therapeutic outcomes is achieved. ...
Prediction of adverse drug events
International Business Machines Corporation
April 27, 2017 - N°20170116376

Embodiments include method, systems and computer program products for predicting adverse drug events on a computational system. Aspects include receiving known drug data from drug databases and one or more of a candidate drug, a drug pair, and a candidate drug-patient pair. Aspects also include calculating an adverse event prediction rating representing a confidence level of an adverse drug event ...
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Monoclonal antibodies to programmed death 1 (pd-1)
Ono Pharmaceutical Co., Ltd.
March 30, 2017 - N°20170088615

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to pd-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The ...
Drug adverse event extraction method and apparatus
Nec Corporation
March 23, 2017 - N°20170083670

A method of extracting a combination of a drug and an adverse event related to the drug includes: for each of positive example combinations, negative example combinations and combinations that are neither positive examples nor negative examples, which are combinations of drug and disease, extracting medical events from medical information data about a patient and generating attribute data based on ...
Prediction and recognition of acute kidney injury after surgery
Roche Diagnostics Operations, Inc.
March 23, 2017 - N°20170082639

Systems, kits, and methods for predicting the risk of an adverse event related to acute kidney injury aki as a consequence of a surgical intervention in a subject. Embodiments of the system and methods include means and steps for determining an amount of liver-type fatty acid binding protein (l-fabp) in a sample, such as a urine-sample of a subject; comparing ...
Hydrant monitoring system and method
Silversmith, Inc.
March 16, 2017 - N°20170072238

A device for transferring adverse event information from a plurality of remote hydrants to a municipal monitoring server comprises detecting an adverse event in a hydrant that relates to an adverse hydrant condition; transferring data representative of the adverse condition to a host server by routing the data along a predefined hopping path; and transferring the data from the host ...
Method and system for the analysis and association of patient-specific and population-based genomic data with ...
Druglogic, Inc.
March 02, 2017 - N°20170061080

A method for assessing and analyzing one or more drugs, adverse effects and associated risks, and patient characteristics resulting from the use of at least drug of interest is disclosed. The method comprises the steps of selecting one or more cases for analysis, said cases describing the behavior between at least one drug of interest and a patient genotype; profiling ...
In vitro diagnostic and prognosis of major adverse events in patients undergoing coronary angiography
Immundiagnostik Ag
March 02, 2017 - N°20170059584

Method of diagnosis and prognosis of contrast media induced nephropathy (cin) comprising the steps of i) taking a urine sample from a patient exposed to the application of contrast media, notably patients subjected to coronary angiography; ii) assessing the level of vitamin d binding protein (vdbp) in the urine sample obtained in step (i); iii) relating the urinary vitamin d ...
Targeted treatment of anerobic cancer
University Hospitals Cleveland Medical Center
March 02, 2017 - N°20170056350

The present invention relates to a pharmaceutical cocktail and methods of treatment involving said cocktail, in particular, a combination of effective amounts of a carbonic anhydrase inhibitor, in combination with effective amounts of an angiogenesis inhibitor, including a vascular endothelial growth factor (vegf) inhibitor such as bevacizumab for the treatment of cancer. In other embodiments, it relates to compositions and ...
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System and method for analyzing adverse event data
Astellas Pharma Europe Ltd.
February 02, 2017 - N°20170032106

A non-transitory memory is configured to store adverse event data. The adverse event data describes whether an individual experienced an adverse event as a result of being administered a therapeutic agent on each day during a time period. A processor, operatively connected to the at least one non-transitory memory, is configured to process the adverse event data and generate an ...
Antibody therapeutics with local activity in the digestive tract
Avaxia Biologics, Incorporated
January 12, 2017 - N°20170008957

This invention provides methods and compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal barrier of the digestive tract but do not deliver levels of antibody to the systemic circulation that have been shown to be necessary for clinical benefit following systemic administration of antibody. This invention further describes therapeutic compositions of antibody ...
Optimization of patient alarm settings for monitoring devices utilizing analytics
General Electric Company
January 05, 2017 - N°20170000424

A monitoring device operable to provide information on data obtained from sensors operably connected between a patient and the device is provided that includes a central processing unit configured to receive incoming data signals from sensors concerning physiological parameters of the patient to compare the incoming data signals to predetermined alarm limits for the physiological parameters to determine an alarm ...
Method for predicting adverse events for home healthcare of remotely monitored patients
General Electric Company
December 29, 2016 - N°20160378943

There is described a method for dynamically computing a patient dynamic risk score indicative of an adverse event occurring on a given day. The method comprises obtaining clinical documentation data, socio-demographic data, answers to remote patient monitoring questionnaires, and vital signs data. The method further comprises using, in a feedforward artificial neural network, the clinical documentation data, the socio-demographic data, ...
Systems and methods for wearable health monitoring
General Electric Company
November 17, 2016 - N°20160331315

Aspects of the present invention relate to recording physiological data sequences while a user participates in various activities. These activities may comprise awake activities, periods of sleep and transitions between sleep and activity. Record sequences are recorded and maintained for a period of time including many cycles of activity. The physiological activity data sequences may then be analyzed to identify ...
Method of providing pirfenidone therapy to a patient
Intermune, Inc.
November 10, 2016 - N°20160324842

The invention relates to methods for decreasing adverse events associated with pirfenidone (5-methyl-1-phenyl-2-(1h)-pyridone) therapy. The invention discloses an optimized dose escalation scheme that results in the patient having increased tolerance to adverse events associated with the administration of pirfenidone. The invention also discloses a starter pack that may be used in conjunction with the dose escalation ...
Prognosis of adverse events in patients with suspected chronic heart failure
B.r.a.h.m.s. Gmbh
November 03, 2016 - N°20160320411

The present invention is in the field of clinical diagnostics. Particularly the present invention relates to the prognosis of adverse events in patients with stable chronic heart failure or being suspected of having stable chronic heart failure by determination of the level of procalcitonin (pct).
Adverse event prioritization and handling
Preventice, Inc.
October 06, 2016 - N°20160292374

Collecting biometric data from a patient provides numerous opportunities for a care provider to monitor the health of the patient. In one embodiment, the biometric data is used to identify health events that are processed in a workflow that includes a plurality of interconnected processing nodes and queues. In one embodiment, the workflow processes the health events using a priority ...