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|| List of recent Actin-related patents
|Use of oligomers of lactic acid in the treatment of gynaecological disorders|
The invention relates to the use of one or more oligomers of lactic acid or a lactic acid oligomeric product for the prophylaxis and/or treatment of a disease or condition that benefits from an acidic environment, especially a gynaecological infection including a bacterial infection such as bacterial vaginosis, unspecific colpitis, senile colpitis, cervicitis, and urethritis, a fungal infection, such as candidosis (candida albicans), cryptococcosis, actinomycosis, or a viral infection, such as human immunodefiency virus (hiv), herpes simplex virus (hsv), human papilloma virus (hpv).. .
|Liquid platemaking process|
A method of making a relief printing element in a liquid photopolymer platemaking process is described. The method comprises the steps of: (a) selectively exposing the liquid photopolymer to actinic radiation through a negative to crosslink and cure portions of the liquid photopolymer; and (b) reclaiming uncured portions of the liquid photopolymer to be reused in the platemaking process.
|Actinically curable silicone hydrogel copolymers and uses thereof|
The present invention provides inks and methods for making colored silicone hydrogel contact lenses. The ink of the invention comprises an actinically-curable binder copolymer comprising fluorine-containing segments and is characterized by having capability to be cured actinically or thermally to form a colored film on a molding surface of a mold or a silicone hydrogel contact lens and by having an increased durability in a solvated state in a silicone-hydrogel lens formulation in relation to a control colored film obtained from a control ink including an actinically-curable fluorine-free binder copolymer.
|Photoemission monitoring of euv mirror and mask surface contamination in actinic euv systems|
Photoelectron emission mapping systems for use with euv (extreme ultraviolet) mask inspection and lithography systems are described. The mapping systems may be used to provide photoelectron emission maps for euv photolithography masks and/or euv mirrors.
|Porifera-based therapeutic compositions for treating and preventing skin diseases|
Methods and protocols of harvesting and processing of porifera species, specifically sponges, and more specifically fresh water species of genus spongilla; testing and storing of the processed spongilla powder; and manufacturing and packaging of spongilla-based therapeutic compositions for treating and preventing skin diseases are disclosed. Treatable skin conditions and diseases include without limitation acne vulgaris, rosacea, seborrheic dermatitis, psoriasis, photo-aging and actinic keratosis, acne vulgaris, psoriasis, photo-aging, wounds, scars, and eczema (atopic dermatitis)..
|Chemical amplification resist composition, resist film using the composition, resist-coated mask blanks, resist pattern forming method, photomask and polymer compound|
A chemical amplification resist composition contains: (a) a polymer compound having a structure where a hydrogen atom of a phenolic hydroxyl group is replaced by a group having a non-acid-decomposable polycyclic alicyclic hydrocarbon structure; and (b) a compound capable of generating an acid upon irradiation with an actinic ray or radiation.. .
|Liquid platemaking with laser engraving|
A method of making a relief image printing element from a liquid photopolymer composition is described. The method includes the steps of (1) casting a liquid photopolymer layer onto a cover sheet and at least substantially simultaneously placing a hacking sheet onto the liquid photopolymer layer; (2) preliminarily exposing the liquid photopolymer layer to actinic radiation to create at least one island of solid photopolymer in the liquid photopolymer layer where it is desirable to laser engrave a relief image; (3) reclaiming uncured liquid photopolymer from the relief image printing element; (4) processing the at least one island of solid photopolymer to remove uncured liquid photopolymer; (5) exposing the at least one island of solid photopolymer to actinic radiation to fully cure the islands of solid photopolymer; and (6) laser engraving the at least one island of solid photopolymer to produce the relief image therein..
A flexible-to-rigid tube is flexible when routed and is then rigidized to increase burst strength. According to the preferred embodiments of the present invention, the flexible-to-rigid tube is included in a cooling plate assembly for transferring heat from electronic components mounted on a circuit board.
|Use of surfactants having at least three short-chain perfluorinated groups rf for manufacturing integrated circuits having patterns with line-space dimensions below 50 nm|
The use of surfactants a, the 1% by weight aqueous solutions of which exhibit a static surface tension <25 mn/m, the said surfactants a containing at least three short-chain perfluorinated groups rf selected from the group consisting of trifluoromethyl, pentafluoroethyl, 1-heptafluoropropyl, 2-heptafluoropropyl, heptafluoroisopropyl, and pentafluorosulfanyl; for manufacturing integrated circuits comprising patterns having line-space dimensions below 50 nm and aspect ratios >3; and a photolithographic process making use of the surfactants a in immersion photoresist layers, photoresist layers exposed to actinic radiation, developer solutions for the exposed photoresist layers and/or in chemical rinse solutions for developed patterned photoresists comprising patterns having line-space dimensions below 50 nm and aspect ratios >3. By way of the surfactants a, pattern collapse is prevented, line edge roughness is reduced, watermark defects are prevented and removed and defects are reduced by removing particles..
|Method of forming pattern|
Provided is a pattern forming method making it possible to obtain a pattern with less scums and watermark defects. The pattern forming method includes the steps of forming a film from an actinic-ray- or radiation-sensitive resin composition includes a resin (a) that exhibits an increased solubility in an alkali developer when acted on by an acid, a compound (b) that generates an acid when exposed to actinic rays or radiation, and a resin (c) containing at least one of a fluorine atom and a silicon atom, exposing the film to light, and developing the exposed film using a tetramethylammonium hydroxide solution whose concentration is less than 2.38 mass %..
|Actinically curable adhesive composition|
A photocurable adhesive composition is disclosed herein that has high adhesive strength and optical clarity and which in the cured state is reworkable and exhibits low propensities for exhibiting glow mark and pooling effects. The composition contains a chain transfer agent, an urethane (meth)acrylate having a plurality of ethylenically unsaturated groups, a (meth)acrylate monomer and a photoinitiator.
|Neutralizing prolactin receptor antibodies and their therapeutic use|
The present invention is directed to the neutralizing prolactin receptor antibody 006-h08, as well as maturated forms thereof, and antigen-binding fragments, pharmaceutical compositions containing them and their use in the treatment or prevention of benign disorders and indications mediated by the prolactin receptor such as endometriosis, adenomyosis, non-hormonal female contraception, benign breast disease and mastalgia, lactation inhibition, benign prostate hyperplasia, fibroids, hyper- and normoprolactinemic hair loss, and cotreatment in combined hormone therapy to inhibit mammary epithelial cell proliferation. The antibodies of the invention block prolactin receptor-mediated signaling..
|Indexing optics for an actinic extreme ultra-violet (euv) reticle inspection tool|
A method for reducing damage and contamination to an optical element in an extreme ultra-violet (euv) reticle inspection system, including, presenting an illumination source to a reticle inspection system, and displacing the optical element in the path of the illumination source from a first portion to a second portion, wherein the first portion is damaged and the second portion is not damaged, and the optical element has a plurality of portions.. .
|Smart memory alloys for an extreme ultra-violet (euv) reticle inspection tool|
An apparatus for actinic extreme ultra-violet (euv) reticle inspection including at least one shape memory metal actuator adapted to displace an inspection component in an euv inspection tool. An apparatus for actinic euv reticle inspection including a tilt mechanism including at least one shape memory metal actuator adapted to angularly displace an inspection component in an euv inspection tool.
|Negative pattern forming method and resist pattern|
A negative pattern forming method, includes: (i) forming a film having a film thickness of 200 nm or more from a chemical amplification resist composition containing (a) a resin capable of increasing a polarity of the resin (a) by an action of an acid to decrease a solubility of the resin (a) for a developer containing one or more organic solvents, (b) a compound capable of generating an acid upon irradiation with an actinic ray or radiation, and (c) a solvent; (ii) exposing the film, so as to form an exposed film; and (iii) developing the exposed film with a developer containing one or more organic solvents.. .
|Arrangement of reticle positioning device for actinic inspection of euv reticles|
A reticle positioning apparatus for actinic euv reticle inspection including a sealed inspection chamber containing a reticle stage for holding a reticle. The reticle stage has a.
|Actinic radiation-curing type ink composition, inkjet recording method, decorative sheet, decorative sheet molded product, process for producing in-mold molded article, and in-mold molded article|
Disclosed is an actinic radiation-curing type ink composition comprising (component a) a monofunctional radically polymerizable monomer and (component b) a polyfunctional acrylate oligomer having a glass transition temperature of no greater than 20° c. And having an acrylate equivalent of at least 300 g/eq, component a comprising (component a-1) an n-vinyl compound and (component a-2) an acrylamide derivative, component a having a content of at least 70 mass % of the entire ink composition, and component a-1 having a content of at least 18 mass % of the entire ink composition..
|Printing form precursor having elastomeric cap layer and a method of preparing a printing form from the precursor|
The invention pertains to a printing form precursor, a method of preparing a printing form from the precursor, and a process of preparing the precursor. The printing form precursor includes a photopolymerizable layer, an elastomeric layer having at least an elastomeric binder and particulate, and an actinic radiation opaque material on, adjacent, or disposed above the elastomeric layer opposite the photopolymerizable layer.
|Methods of treating dermatological disorders and inducing interferon biosynthesis with shorter durations of imiquimod therapy|
Pharmaceutical formulations and methods for the topical and/or transdermal delivery of imiquimod, including creams, ointments and pressure-sensitive adhesive compositions to treat dermatological disorders, namely, viral infections, such as type i or type ii herpes simplex infections and genital warts, actinic keratosis and superficial basal cell carcinoma, and to induce interferon biosynthesis, with shorter durations of therapy, than currently approved for imiquimod by the food & drug administration (“fda”).. .
|Constitutively active prolactin receptor variants as prognostic markers and therapeutic targets to prevent progression of hormone-dependent cancers towards hormone-independence|
The present invention relates to an in vitro method of prognosing outcome of hormone-dependent cancer in a subject comprising detecting a constitutively activating mutation in the prolactin receptor (prlr) gene in a nucleic acid sample previously obtained from said subject, said constitutively activating mutation being preferably a mutation resulting in the expression of a mutant prolactin receptor wherein the isoleucine residue at position 146 is substituted with leucine or a mutation resulting in the expression of a mutant prolactin receptor wherein the isoleucine residue at position 76 is substituted with valine.. .
|Method for producing flexographic printing plates using uv-led irradiation|
A method for producing flexographic printing plates, using a photopolymerizable flexographic printing element having, arranged one atop another, a dimensionally stable support, a photopolymerizable, relief-forming layer, an elastomeric binder, an ethylenically unsaturated compound, and a photoinitiator, and optionally a rough, uv-transparent layer, a particulate substance, and digitally imagable layer. The method includes: (a) producing a mask by imaging the digitally imagable layer, (b) exposing the photopolymerizable, relief-forming layer through the mask with actinic light, and photopolymerizing the image regions of the layer, and (c) developing the photpolymerized layer by washing out the unphotopolymerized regions of the relief-forming layer with an organic solvent, or by thermal development.
|Room temperature electrodeposition of actinides from ionic solutions|
Uranic and transuranic metals and metal oxides are first dissolved in ozone compositions. The resulting solution in ozone can be further dissolved in ionic liquids to form a second solution.
|Use of prolactin receptor antagonist and chemotherapeutic drug for treating ovarian cancer|
The present invention relates generally to the field of cancer diagnosis and treatment, and more particularly to compositions and methods that may be useful for eliminating cancer cells with stem-like characteristics. The disclosed compositions and methods may also be useful for managing breast cancer, ovarian cancer, cervical cancer or endometrial (uterine) cancer with metastases; and visualizing the cancer cells in patient's body.
|Actinic radiation-curing type ink set, inkjet recording method, and printed material|
Disclosed is an actinic radiation-curing type ink set comprising a colored ink composition and a clear ink composition (c1), the colored ink composition comprising (component a1) a radically polymerizable compound, (component b1) a polymerization initiator, and (component d) a colorant, and the clear ink composition (c1) comprising (component a2) a radically polymerizable compound, (component b2) a polymerization initiator, and (component s) an organic solvent.. .
|Clean flexographic printing plate and method of making the same|
A clean running flexographic relief image printing element and a method of making the same is described. The relief image printing element comprises (a) a backing layer; (b) a floor layer disposed on the backing layer and comprising a photopolymer containing a silicone monomer or silicone oil, wherein the cured floor layer has a surface energy of between about 18 to about 25 dynes/cm; (c) a cap layer disposed on the floor layer and comprising a photocurable composition that is capable of being imagewise exposed to actinic radiation to create a relief image therein, wherein the cap layer has a surface energy of between about 30 and about 40 dynes/cm; and (d) a removable cover sheet.
|Molecules for the photodynamic treatment of tumors and hyperplasias|
This invention relates to pharmaceutical compositions comprising a sulfonated biological precursor of thymidine, such as a precursor of 4-thiothymidine (4-tt), and their use in the photodynamic treatment of skin hyperplasias, including cancer, psoriasis, actinic keratosis and keloids, by topical or systemic administration.. .
|Method of metal deposition|
A method of forming a metal layer on an electrically insulating substrate comprises depositing a photocatalyst layer onto the substrate and depositing a mask layer comprising voids on the substrate, such as a layer of latex microparticles with voids between them, to give an open pore structure to the mask. An electroless plating solution is then provided on the photocatalyst layer, and the photocatalyst layer and electroless plating solution are illuminated with actinic radiation whereby deposition of metal from the electroless plating solution to form a metal layer on the photocatalyst layer is initiated whereby the metal deposits in the voids of the mask layer.
|Method for preparing a relief printing form|
The invention provides a method for preparing a relief printing form from a photosensitive element. The method includes forming an in-situ mask disposed above a photopolymerizable layer of the photosensitive element, exposing the element to actinic radiation through the in-situ mask in an environment having an inert gas and a concentration of oxygen between about 50,000 ppm and about 2000 ppm to form at least a polymerized portion and an unpolymerized portion of the layer, and treating by heating the exposed element to a temperature sufficient to cause the unpolymerized portion to melt, soften, or flow..
|Flat panel detector incorporating silk layer(s)|
One or more techniques and/or systems described herein implement, among other things, a flat panel detector component for detecting actinic and non-actinic radiation, or the formation thereof. The flat panel detector component comprises a plurality of layers, where at least one of the layers comprises silk.
|2 x 2 x 2 week dosing regimen for treating actinic keratosis with pharmaceutical compositions formulated with 3.75 % imiquimod|
Pharmaceutical formulations and methods for the topical or transdermal delivery of 1-isobutyl-1h-imidazo[4,5-c]-quinolin-4-amine or 1-(2-methylpropyl)-1h-imidazo[4,5-c]quinolin-4-amine, i.e., imiquimod, to treat actinic keratosis with short durations of therapy, than currently prescribed for the commercially available aldara® 5% imiquimod cream, as now approved by the u.s. Food & drug administration (“fda”), are disclosed and described.
|Composition for the treatment of superficial lesions|
The invention relates to a composition for the treatment of superficial lesions, in particular skin lesions, mucous membrane lesions and/or nail lesions, an applicator comprising such a composition and the use of such a composition. The composition comprises an effective amount of trichloroacetic acid, at least one thickener, and at a physiologically acceptable solvent.
|Integrated membrane lamination and uv exposure system and method of using the same|
A combined laminating and exposing apparatus for exposing a photosensitive printing blank to actinic radiation in a printing plate manufacturing system and a method of using the same are disclosed. The photosensitive printing blank comprises a backing layer, at least one photocurable layer disposed on the backing layer, and a laser ablatable mask layer disposed on the at least one photocurable layer, wherein the laser ablatable mask layer is laser ablated to create an in situ negative in the laser ablatable mask layer.
|Crystallisation facilitators for the synthesis of metal organic frameworks|
A crystallisation facilitator for promoting crystal growth of a metal-organic framework, the crystallisation facilitator comprising at least one of: a metal or ionic form of that metal, or a compound including a metal, which is selected from the group consisting of group 1 through 16 metals of the iupac periodic table of the elements including actinides, and lanthanides, and combinations thereof. A method of synthesising a metal-organic framework using the crystallisation facilitator is also described..
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