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Acids patents



      
           
This page is updated frequently with new Acids-related patent applications. Subscribe to the Acids RSS feed to automatically get the update: related Acids RSS feeds. RSS updates for this page: Acids RSS RSS


Methods of co-detecting mrna and small non-coding rna

Date/App# patent app List of recent Acids-related patents
08/28/14
20140245474
 Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold patent thumbnailnew patent Nucleotide sequences and polypeptides encoded thereby useful for modifying plant characteristics in response to cold
Methods and materials for modulating cold tolerance levels in plants are disclosed. For example, nucleic acids encoding cold tolerance-modulating polypeptides are disclosed as well as methods for using such nucleic acids to transform plant cells.
08/28/14
20140243540
 Algae extraction process patent thumbnailnew patent Algae extraction process
A method of extracting oil from algae by drying algae paste to a predetermined moisture content, contacting the algae paste with a polar solvent to make an algae-solvent solution and extracting oils from the algae paste into a solvent-oil solution, and separating extracted algae from the solvent-oil solution. An oil of whole and unhydrolyzed phospholipids, whole and unhydrolyzed glycolipids, lysolipids, and carotenoids extracted by the above method.
08/28/14
20140243503
 Fgf21 mutants and uses thereof patent thumbnailnew patent Fgf21 mutants and uses thereof
The invention provides nucleic acid molecules encoding fgf21 mutant polypeptides, fgf21 mutant polypeptides, pharmaceutical compositions comprising fgf21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.. .
08/28/14
20140243469
 Aqueous coating compositions patent thumbnailnew patent Aqueous coating compositions
The invention relates to an aqueous coating composition comprising a dispersion of an acrylic copolymer a, a cross-linker b which is a multifunctional isocyanate b1, or an aminoplast crosslinker b2 or a combination of both b1 and b2, and water, wherein the acrylic copolymer a has moieties derived from alkyl(meth)acrylates a1, from hydroxyalkyl(meth)acrylates a2, from olefinically unsaturated carboxylic acids a3, and optionally, further olefinically unsaturated monomers a4 selected from the group consisting of vinyl aromatics a41, vinyl esters a42, vinyl halogenides a43, olefinically unsaturated amides a44, olefins a45, vinyl ester a46, and from an olefinically unsaturated surface-active compound a5 which has at least one olefinic unsaturation, and at least one hydrophilic group per molecule, a method for its preparation, and the use thereof in coating metal substrates, stone, concrete, paper and cardboard.. .
08/28/14
20140243404
 Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby patent thumbnailnew patent Unique halogen-induced cyclizations, reagents therefor, and compounds produced thereby
This disclosure is related to halonium compounds useful for cyclization of polyenes, alkenoic acids, and alkenyl alkyl ethers, and halogenation of aromatic compounds. The synthesis of such halonium compounds, compounds made using such halonium compounds, and synthesis of natural compounds, including decalins, using the halonium compounds is also disclosed.
08/28/14
20140243399
 Engineered nucleic acids and methods of use thereof patent thumbnailnew patent Engineered nucleic acids and methods of use thereof
Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger rnas, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing..
08/28/14
20140243397
 Cxcr4 inhibiting carriers for nucleic acid delivery patent thumbnailnew patent Cxcr4 inhibiting carriers for nucleic acid delivery
The present invention generally relates to carriers including polymers and lipids that comprise a cxcr4 inhibiting moiety. More specifically, these carriers are biodegradable and can be bioreducible polymers that comprise a cxcr4 inhibiting moiety.
08/28/14
20140243391
 Phospholipid-detergent conjugates and uses thereof patent thumbnailnew patent Phospholipid-detergent conjugates and uses thereof
The invention relates to novel compounds, in particular novel o-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy..
08/28/14
20140243335
 Substituted hydoxamic acids and uses thereof patent thumbnailnew patent Substituted hydoxamic acids and uses thereof
Wherein r1, r1b, r2a, r2b, r2c, and r2d have values as described in the specification, useful as inhibitors of hdac6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders..
08/28/14
20140243334
 Substituted hydoxamic acids and uses thereof patent thumbnailnew patent Substituted hydoxamic acids and uses thereof
Wherein r1a, r1b, r1c, r2a, r2b, r2c, and r2d have values as described in the specification, useful as inhibitors of hdac6. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of proliferative, inflammatory, infectious, neurological or cardiovascular diseases or disorders..
08/28/14
20140243323
new patent Antimicrobial locking solutions comprising taurinamide derivatives and biologically acceptable salts and acids, with the addition of small concentrations of heparin
(c) heparin at a low concentration.. .
08/28/14
20140243281
new patent Bile acid recycling inhibitors for treatment of pediatric cholestatic liver diseases
Provided herein are pediatric dosage forms for use in the treatment of a pediatric cholestatic liver disease by non-systemically administering to an individual in need thereof a therapeutically effective amount of the pediatric dosage form comprising an apical sodium-dependent bile acid transporter inhibitor (asbti) or a pharmaceutically acceptable salt thereof. Also provided are said pediatric dosage form for use in the treatment of a pediatric liver disease, for use in decreasing the levels of serum bile acids or hepatic bile acids, for use in the treatment of pruritis, for use in reducing liver enzymes or bilirubin comprising non-systemically administering to an individual in need thereof a therapeutically effective amount of a pediatric formulation comprising an asbti or a pharmaceutically acceptable salt thereof..
08/28/14
20140243268
new patent Erbb2 peptides
Compositions that inhibit or block the interaction between erbin and erbb2 and methods of their use are provided. Preferred compositions include peptides that inhibit or block erbin and erbb2 interaction under physiologic conditions in a subject.
08/28/14
20140243252
new patent Laundry detergent formulation
An improved binder for use in making laundry detergent compositions, more specifically bleach activator granules, is described. The binder utilizes glycerin as a replacement for fatty acids in the overall granule mixture which improves solubility and reduces odor..
08/28/14
20140243238
new patent Methods of co-detecting mrna and small non-coding rna
Disclosed herein are methods of co-detecting presence of target messenger rna (mrna) and small non-coding rna (for example, mirna) in a sample. The disclosed methods can be used to simultaneously detect mrna and small non-coding rna in a single assay (for example in the same reaction or the same well of a multi-well assay).
08/28/14
20140243235
new patent Peripheral neuropathy diagnosis
Genes whose expression is correlated with the presence of cidp or vasculitic neuropathy are disclosed. Probes and sets of nucleic acids and proteins specific for these genes are described, as are molecular and immunological methods for aiding in the diagnosis of these disease conditions in a subject..
08/28/14
20140243224
new patent Gel patterned surfaces
Provided is an array including a solid support having a surface, the surface having a plurality of wells, the wells containing a gel material, the wells being separated from each other by interstitial regions on the surface, the interstitial regions segregating the gel material in each of the wells from the gel material in other wells of the plurality; and a library of target nucleic acids in the gel material, wherein the gel material in each of the wells comprises a single species of the target nucleic acids of the library. Methods for making and using the array are also provided..
08/28/14
20140243216
new patent Methods for separating nucleic acids by size
The present invention pertains to a method for isolating nucleic acids by size from a sample comprising nucleic acids of different sizes using an anion exchange matrix, wherein nucleic acids of a preselected size or a preselected size range are isolated by varying the ph value during elution and/or binding.. .
08/28/14
20140243213
new patent Analysing sequencing bias
The present invention relates to methods for determining the sequence bias of a sequencing technique. Furthermore, the invention relates to methods to reduce or enhance sequence bias during sequencing of nucleic acids via techniques involving adaptor ligations.
08/28/14
20140243210
new patent Purification of immunoglobulins using affinity chromatography and peptide ligands
An immunoglobulin binding peptide having the general formula, from amino terminus to carboxy terminus, of z—r1—r2—r3—r4—r5—r6—x, is described, wherein: r1 is h or y; r2 is a hydrophobic, preferentially aromatic, amino acid (for example w, f, y, v); r3 is a positively charged or aromatic amino acid (for example r, h, f, w); r4 is a hydrophobic or positively charged amino acid (for example g, y, r, k, l); r5 is a positively charged or aromatic amino acid (for example w, f, r, h, y); r6 a random amino acid but preferably hydrophobic or negatively charged (for example v, w, l, d, h); x is present or absent and when present is a linking group; and z is present or absent and when present is a capping group bonded to the n terminus of r1; and wherein the amino acids of said peptide are in d form, l form, or a combination thereof. Methods of using such peptides for the purification of immunoglobulins are also described.
08/28/14
20140242661
new patent Process control method
A process control method, the method comprising the steps of: (i) passing a portion of a biomass containing liquid from a first reactor (12) in which a batch anaerobic digestion of organic material is being or has been conducted to a liquid storage vessel (14), methane being produced in both the first reactor (12) and the liquid storage vessel (14); (ii) passing a portion of the liquid from the liquid storage vessel (14) back to a first reactor (12) that may or may not be the same reactor (12) of step (i); (iii) passing a portion of the liquid from either or both of the first reactor (12) and the liquid storage vessel (14) to a second reactor (16); and (iv) passing a portion of the liquid from the second reactor (16) to either the liquid storage vessel (14) or to the first reactor (12), wherein the direction of liquid to the second reactor (16) allows control of the level of volatile fatty acids (vfa) in the liquid to be returned to the first reactor (12) by way of exposure to additional anaerobic methanogenic microorganisms provided in that second reactor (16). An apparatus (10) for the control of process conditions in a process for the microbiological digestion of organic waste material is also disclosed..
08/28/14
20140242649
new patent Hybrid organic-inorganic system for producing biofuels
The present invention provides for a system for converting co2 and h2 to one or more biologically derived compounds. In some embodiments, the system comprises a host cell comprising one or more nucleic acids encoding genes for a recombinant surface display protein which is capable of tethering an electrocatalyst molecule, such as a cobalt(ii) complex supported by tetradentate polypyridyl ligand 2-bis(2-pyridyl)(methoxy)methyl-6-pyridylpyridine (py4), and enzymes for synthesizing a biologically derived compound, such as an alkane, alcohol, fatty acid, ester, or isoprenoid..
08/28/14
20140242648
new patent Protein having activity to promote fatty acid chain elongation, gene encoding same and use thereof
The present invention relates to a protein having an activity to promote fatty acid chain elongation, a polynucleotide encoding the same, etc. The present invention provides, for example, a polynucleotide containing the nucleotide sequence shown in seq id no: 1 or 4, a polynucleotide encoding a protein which consists of the amino acid sequence shown in seq id no: 2, an expression vector and a transformant, each containing such a polynucleotide, a method for preparing lipids or fatty acids by using such a transformant, or a food or the like containing lipids or fatty acids prepared by such a method..
08/28/14
20140242637
new patent Artificial introns
The invention concerns the field of recombinant gene engineering. It concerns novel artificial introns and compositions comprising such introns as well as a method to improve expression of polypeptides from nucleic acids such as cloned genes, especially genes encoding antibodies and antibody derived fragments, and the production of various polypeptides in eukaryotic host cells using said novel artificial intron sequences..
08/28/14
20140242594
new patent Methods and compositions for preparation of nucleic acids
A method for isolating genomic dna (gdna) from a biological material. In some embodiments, the method includes (a) contacting a sample that contains gdna with a solution of hydroxide and a detergent under conditions and for a time sufficient to degrade a cell wall, a cell membrane, a nuclear membrane, a nucleoprotein, or combinations thereof and/or to denature the gdna; (b) mixing into the solution resulting from step (a) a solution characterized by high salt and sufficient buffering capacity to reduce the ph of the solution to less than 10, thereby producing a neutralized solution; (c) centrifuging the sample at a speed and length of time sufficient to clarify the preparation; and (d) removing insoluble material from the neutralized and clarified preparation, whereby a solution of gdna is produced.
08/28/14
20140242253
new patent Process for solubilizing protein
Herein disclosed is a process for solubilizing protein from a biological source selected from the group consisting of animal tissue and keratinous material and combinations thereof, the process comprising: forming an alkaline slurry comprising the biological source and a first alkali comprising hydrated lime or quicklime; heating the alkaline slurry to a first temperature of at least 50° c. For a first treatment time to solubilize protein while minimizing degradation of amino acids and obtain a first treated slurry; separating from the first treated slurry a first liquid product and a solid product, wherein the first liquid product comprises the solubilized protein and calcium; and removing at least a portion of the calcium from the liquid product by adjusting ph to higher than 8 to precipitate calcium and produce a low-calcium liquid product..
08/28/14
20140242238
new patent Algae extraction process
A method of extracting oil from algae by drying algae paste to a predetermined moisture content, contacting the algae paste with a polar solvent to make an algae-solvent solution and extracting oils from the algae paste into a solvent-oil solution, and separating extracted algae from the solvent-oil solution. An oil of whole and unhydrolyzed phospholipids, whole and unhydrolyzed glycolipids, lysolipids, and carotenoids extracted by the above method.
08/28/14
20140242216
new patent Amino acid and protein hydrolysate based formulas with a stable emulsion system
The present disclosure relates in part to an emulsion system comprising a waxy starch. The emulsion system is useful, in some embodiments, for incorporation into infant formulas comprising protein equivalent sources, such as formulas designed for individuals with certain protein allergies.
08/28/14
20140242193
new patent Lithium compositions
2:1 cocrystals of amino acids and li+ salts crystallize from hot water to afford water stable cationic networks based upon tetrahedral lithium cations: bilayered square grids, a lithium zeolitic metal-organic material (lizmom) and several lithium diamondoid metal-organic materials (lidmoms). The compositions may be used as a pharmaceutical for the treatment of suicidality and other disorders that require lithium to penetrate the blood brain barrier and exert therapeutic effects in the cns.
08/28/14
20140242106
new patent Staphylococcus aureus proteins and nucleic acids
The invention provides proteins from staphylococcus aureus including amino acid sequences and the corresponding nucleotide sequences. The proteins are useful for vaccines, immunogenic compositions, diagnostics, enzymatic studies and also as targets for antibiotics..
08/28/14
20140242077
new patent Methods and compositions for modulating an immune response
Provided are multispecific binding proteins and methods for using these multispecific binding proteins to modulate the activation state of immune cells, such as t-cells (e.g., cytotoxic t-cells). Also provided are methods of modulating an immune response (e.g., cell killing by cytotoxic t-cells) in a subject (e.g., a human subject).
08/28/14
20140242055
new patent Compositions containing non-polar compounds
Provided herein are compositions and methods for preparing foods and beverages that contain additives, such as nutraceuticals, pharmaceuticals, and supplements, such as essential fatty acids, including omega-3 fatty acids, omega-6 fatty acids, conjugated fatty acids, and other fatty acids; phytochemicals, including phytosterols; other oils; and coenzymes, including coenzyme q10, and other oil-based additives.. .
08/28/14
20140242036
new patent Process for potentiating the production of lingzhi mushroom (ganoderma lucidum) substances and antifungal activity thereof
The instant invention refers to a novel process for potentiating the production of substances with antifungal activity obtained from ganoderma lucidum, using a technological device for the differential, qualitative and quantitative expression of proteins and other bioactive molecules, selected from the group consisting of polysaccharides, triterpenoids, fatty acids and ganoderic acids. The compositions containing said substances showed antifungal activity and mycelium growth and fungi ascospore germination inhibiting activity, amongst them mycosphaerella fijiensis, primary pathogenic agent causing black sigatoka disease in banana and plantain crop fields..
08/28/14
20140239223
new patent Method of making a formulation for deactivating nucleic acids
The disclosure relates to formulations for use in deactivating nucleic acids and methods of making and using the same.. .
08/28/14
20140238859
new patent Nucleic acid sequencing by electrochemical detection
Provided herein is technology relating to sequencing nucleic acids and particularly, but not exclusively, to devices, methods, and systems for sequencing-by-synthesis using changes in ph to monitor base addition. In some embodiments the electrochemical hydrogen ion sensor is a microfabricated mixed metal oxide electrode and in some embodiments the electrochemical hydrogen ion sensor is a membrane electrode.
08/28/14
20140238625
new patent Recording medium
A recording medium includes a substrate, and a deinking agent incorporated in the substrate, on the substrate in a layer, or both in the substrate and on the substrate in a layer. The deinking agent is chosen from an unsaturated fatty acid having from 19 to 23 carbon atoms and combinations of these unsaturated fatty acids.
08/21/14
20140237687
Plants having enhanced yield-related traits and a method for making the same
The present invention provides a method for enhancing various economically important yield-related traits in plants by modulating expression in a plant of a nucleic acid encoding a patl (patellin) polypeptide, a prp38 (precursor rna processing factor 38) polypeptide, an ada2 (adaptor 2) polypeptide, a gata-like polypeptide, or a wd40 repeat (wdr) 23-like polypeptide. The present invention also concerns plants having modulated expression of a nucleic acid encoding a patl polypeptide, a prp38 polypeptide, an ada2 polypeptide, a gata-like polypeptide, or a wdr23-like polypeptide, which plants have improved yield-related traits relative to corresponding wild type plants or other control plants.
08/21/14
20140237686
Transgenic plants resistant to non-protein amino acids
Transgenic plants resistant to bio-herbicides, particularly to phytotoxic non-protein amino acids including the meta-tyrosine (m-tyrosine) amino acid analog and salts thereof, means and methods for producing the transgenic plants.. .
08/21/14
20140237632
Rapidly maturing fluroscent proteins and methods for using the same
Nucleic acid compositions encoding rapidly maturing fluorescent proteins, as well as non-aggregating versions thereof (and mutants thereof) as well as the proteins encoding the same, are provided. The proteins of interest are proteins that are fluorescent, where this feature arises from the interaction of two or more residues of the protein.
08/21/14
20140235865
Method for producing tetrazole-substituted anthranilic acid diamide derivatives by reacting pyrazolic acids with anthranilic acid esters
In which r1, r2, r3, r4, q and z have the meanings given in the description, by reacting pyrazole acids with anthranilic esters.. .
08/21/14
20140235842
Convenient and efficient purification method for chemically labeled nucleic acids
In particular, the present invention relates to a convenient method for purifying labeled nucleic acids in a fast manner with high efficiency from a mixture of unreacted hydrophobic chemical probes, unreacted nucleic acids and labeled nucleic acids, comprising the steps of reacting hydrophobic chemical probe and nucleic acids in an aqueous solution to prepare a reacted solution; adding organic solvent to the reacted solution and stirring it to obtain a mixed solution; and centrifuging the mixed solution and removing organic solvent phase.. .
08/21/14
20140235841
Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
The invention relates to our discovery of a novel double-stranded ribonucleic acid (dsrna) having specific biological activities, which includes acting as a selective agonist for activation of the toll-like receptor 3. Its “rugged” molecular structure as measured by physico-chemical techniques is resistant to molecular unfolding (i.e., denaturation).
08/21/14
20140235833
Method of classifying antibody, method of identifying antigen, method of obtaining antibody or antibody set, method of constructing antibody panel and antibody or antibody set and use of the same
The present invention relates to an isolated antibody against her1, an isolated antibody against cd147, an isolated antibody against cd73, and an isolated antibody against epcam; reagents and compositions including said antibodies; and uses of said reagents, compositions, and antibodies. The present invention also relates to nucleic acids and vectors expressing said antibodies.
08/21/14
20140235819
Deuterated cyclosporine analogs and methods of making the same
Cyclosporine derivatives are disclosed which possess enhanced efficacy and reduced toxicity over naturally occurring and other presently known cyclosporins and cyclosporine derivatives. The cyclosporine derivatives of the present invention are produced by chemical and isotopic substitution of the cyclosporine a (csa) molecule by: (1) chemical substitution and optionally deuterium substitution of amino acid 1; and (2) deuterium substitution at key sites of metabo-lism of the cyclosporine a molecule such as amino acids 1, 4, 9.
08/21/14
20140235789
Solid phase peptide synthesis via side chain attachment
The present application discloses peptides and peptaibols of high purity may be obtained by solid phase peptide synthesis using as the starting resin hydroxy amino acids, hydroxy amino acid amides, hydroxy amino alcohols or small peptides containing hydroxy amino acids attached to polymers through their side chain.. .
08/21/14
20140235779
Processing zinc diacrylate dispersed in high-cis polybutadiene
The present invention provides a method and product that provides a dust-free homogeneous dispersion of zinc diacrylate in polybutadiene for use in golf balls in which a first and a second processing promoters are used in the production of the dispersion and incorporated into the dispersions, such first processing promoters including low molecular weight polyethylene, fatty acids, and zinc salts of fatty acids and such second processing promoters being metal oxides including zinc oxide, magnesium oxide, and calcium oxide.. .
08/21/14
20140235733
Plants expressing delta6-desaturase genes and oils from these plants containing pufas and method for producing unsaturated fatty acids
The present invention relates to an improved process for the preparation of unsaturated fatty acids and to a process for the preparation of triglycerides with an increased content of unsaturated fatty acids. The invention relates to the generation of transgenic microorganism, with an increased content of fatty acids, oils or lipids with Δ6 double bonds owing to the expression of a moss Δ6-desaturase.
08/21/14
20140235715
Taste masking formulations of fatty acids
Methods and formulations for improving the sensory characteristics and stability of dietary fatty acids for use in beverages, liquid concentrates, or other formulations are disclosed.. .
08/21/14
20140235483
Parallel determination of competitive binding and target specificity of a binding compound library by high-throughput dna sequencing
The invention is directed to a method for analyzing the competitive binding and target (or ligand) specificity of large numbers of candidate binding compounds with respect to a predetermined reference compound. That is, the invention provides a method for essentially conducting a massively parallel elisa on each member of an entire library of candidate binding compounds at the same time.
08/21/14
20140235470
Multiplex nucleic acid detection methods
Methods for multiplex ligation-dependent probe amplification include (a) providing a sample tissue to query different target nucleic acids, (b) providing different probe sets for each of the target nucleic acids, each probe set including a first locus specific probe having a first adapter sequence and a first target specific portion and a second locus specific probe having a second adapter sequence, and a second target specific portion adjacent to the first target specific portion, (c) hybridizing the probe sets to the target sequences to form hybridization complexes, (d) ligating the hybridization complexes to form ligated probes, (e) amplifying the ligated probes to form amplicons, the amplifying step being carried out with a first universal primer including a region complementary to the first adapter sequence and a second universal primer including a region complementary to the second adapter sequence, and (f) detecting the amplicons in a detection system by sequencing each of the amplicons.. .
08/21/14
20140235464
Detection and quantification of biomolecules using mass spectrometry
The present invention is directed in part to a method for detecting a target nucleic acid using detector oligonucleotides detectable by mass spectrometry. This method takes advantage of the 5′ to 3′ nuclease activity of a nucleic acid polymerase to cleave annealed oligonucleotide probes from hybridized duplexes and releases labels for detection by mass spectrometry.
08/21/14
20140235432
Transition metal-containing catalysts and processes for their preparation and use as oxidation and dehydrogenation catalysts
This invention relates to the field of heterogeneous catalysis, and more particularly to catalysts including carbon supports having formed thereon compositions which comprise a transition metal in combination with nitrogen and/or carbon. The invention further relates to the fields of catalytic oxidation and dehydrogenation reactions, including the preparation of secondary amines by the catalytic oxidation of tertiary amines and the preparation of carboxylic acids by the catalytic dehydrogenation of alcohols..


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