|| List of recent Acids-related patents
|Compositions and methods for remediation of chlorinated polyaromatic compounds|
The present invention relates to compositions and methods that are effective in the remediation of contaminants found in natural sources such as groundwater, surface water, soil and manufactured products. The disclosed compositions and methods provide a method for remediating chlorinated polyaromatic compounds by treating them under pressure and heat with concentrated acids and chloride salts.
|Compositions and methods for recognition of rna using triple helical peptide nucleic acids|
Peptide nucleic acids containing thymidine and 2-aminopyridine (m) nucleobases formed stable and sequence selective triple helices with double stranded rna at physiologically relevant conditions. The m-modified pna displayed unique rna selectivity by having two orders of magnitude higher affinity for the double stranded rnas than for the same dna sequences.
|Novel n- and c-terminal substituted antagonistic analogs of gh-rh|
There is provided a novel series of synthetic analogs of hgh-rh(1-29)nh2 (seq id no: 1) and hgh-rh(1-30)nh2. Of particular interest are those carrying phac, n-me-aib, dca, ac-ada, fer, ac-amc, me-nh-sub, phac-ada, ac-ada-d-phe, ac-ada-phe, dca-ada, dca-amc, nac-ada, ada-ada, or ch3—(ch2)10—co-ada, at the n-terminus and β-ala, amc, apa, ada, ae2a, ae4p, ε-lys(α-nh2), agm, lys(oct) or ahx, at the c-terminus.
|Agent for imparting impact resistance to polylactic acid resin|
An impact resistance enhancing agent for a polylactic acid-based resin, containing a polyglycerol fatty acid ester made from a fatty acid containing at least one member selected from the group consisting of caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, and oleic acid, in an amount of 80% by mass or more of the constituting fatty acids, and a polyglycerol having an average degree of polymerization of from 2 to 40. The polylactic acid-based resin composition containing an impact resistance enhancing agent for a polylactic acid-based resin of the present invention has excellent impact resistance properties, so that the resin composition can be suitably used in, for example, agricultural materials, food wrapping materials, and other wrapping materials, and the like..
|Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation|
Disclosed herein are cohesive soft tissue fillers, for example, dermal and subdermal fillers, based on hyaluronic acids and optionally including proteins. In one aspect, hyaluronic acid-based compositions described herein include zero-length cross-linked moieties and optionally at least one active agent.
|Engineered nucleic acids and methods of use thereof for non-human vertebrates|
Provided are formulations, compositions, kits and methods for delivering biological moieties such as modified nucleic acids into cells to induce, reduce or modulate protein expression in non-human vertebrates.. .
|Compositions comprising amino acids for prevention and/or treatment of renal disorders|
Composition comprising leucine, isoleucine, valine, threonine and lysine for use in prophylactic and/or therapeutic treatment of renal disorders in a subject, preferably an elderly subject.. .
|T cell receptors and related materials and methods of use|
The invention provides t cell receptors (tcrs) having antigenic specificity for a cancer antigen, e.g., tyrosinase. Also provided are related polypeptides, proteins, nucleic acids, recombinant expression vectors, isolated host cells, populations of cells, and pharmaceutical compositions.
Enzymes tend to be inactivated during wash by a bleach catalyst in combination with a source of organic peroxyacids. The risk of enzyme inactivation by active bleach catalyst is reduced when the release of the enzyme into the wash solution is delayed.
|Dna libraries encoding frameworks with synthetic cdr regions|
A synthetic dna library or a member of a synthetic dna library of antibodies or fragments of antibody molecules having heavy chain(s) and lacking light chain(s) is described wherein the cdr within variable domains are synthesized using randomly assembled trinucleotide phosphoramidites (trimer phosphoramidites) to eliminate unwanted cysteine amino acids and/or stop codons.. .
|Process for determining the concentration of nucleic acids|
A process is disclosed for determining the concentration of nucleic acids in a sample in a microfluidic device. In at least one embodiment, the method includes a) introducing the sample into a first chamber, b) carrying out a number of cycles of an amplification reaction to be carried out in cycles for amplifying nucleic acids, c) transferring a defined volume which is a fraction of the volume of the first chamber and which has amplified nucleic acids into a second chamber and replacing the transferred defined volume with fresh reagents for the amplification reaction, d) determining the concentration of the amplified nucleic acids in a second chamber equipped with an element to determine concentrations, and e) repeating steps b)-d) until a concentration of the amplified nucleic acids which is within a range is determined in the second chamber.
|Agricultural compositions comprising mono or dicarboxylic acid esters of polyhydric alcohols|
Suggested are agricultural compositions, comprising one or more esters of c6-c22 monocarboxylic acids or c2-c20 dicarboxylic acids and polyhydric alcohols selected from the group consisting of diglycerol, triglycerol, oligo- or polyglycerol and their respective alkylene oxide adducts, one or more biocides, and optionally, one or more oil components or solvents and/or one or more emulsifiers, wherein the esters are essentially free of esters of monomeric glycerol and esters of alkylene oxide adducts of monomeric glycerol. The esters are useful for forming agricultural compositions using hard water..
|Transcriptome transfer produces cellular phenotype conversion|
The present invention includes methods for effecting phenotype conversion in a cell by transfecting the cell with phenotype-converting nucleic acid. Expression of the nucleic acids results in a phenotype conversion in the transfected cell.
|Method for producing polyhydroxyalkanoic acid|
Embodiments of the invention relate to the microbial production of polyhydroxyalkanoic acids, or polyhydroxyalkanoates (pha), from substrates which cannot be used as a source of carbon and/or energy for microbial growth or pha synthesis and which have microbial and environmental toxicity. According to one embodiment of the invention, a process for the production of pha is provided wherein an enzyme such as methane monooxygenase is used to convert volatile organic compounds into pha through the use of microorganisms that are unable to use volatile organic compounds as a source of carbon for growth or pha production..
|Microfluidic device-based nucleic acid purification method|
A method is provided for purifying nucleic acid from a sample in a microfluidic device. The method can be used to purify nucleic acids from any source known in the art that comprises nucleic acids, such as prokaryotic or eukaryotic organisms, viruses, cell, tissues, organs, etc.
|Methods and compositions for enrichment of nucleic acids in mixtures of highly homologous sequences|
Provided are methods of enrichment and detection of target nucleic acids during target amplification in the presence of excess amounts of highly homologous sequences, said methods having substantial diagnostic utility (e.g., cancer diagnostics). Provided are amplification reaction mixtures having at least one cleavage-directing oligonucleotide, the respective binding sites of which, for the target and homologous sequences, include one or more nucleotide positions differing in sequence between the target homologous sequences.
|Compositions for detecting small rnas|
Compositions and reaction mixtures are provided for the detection of small rna target nucleic acids, preferably mirna target nucleic acids, wherein the compositions and reaction mixtures provide for sensitive and specific detection of the target nucleic acids. The compositions and reaction mixtures include one or more of a first amplification oligomer that is preferably an extender primer, a target capture oligomer that is preferably at least partially double stranded, a promoter primer/provider, a reverse primer that is preferably a universal primer and a detection probe.
|Solvent-free wire enamel composition|
The present invention relates to a solvent-free wire enamel composition containing extrudable, polyesterimide-containing binders, prepared from polyols, polycarboxylic acids, imide-forming components, and structural elements which are crosslinkable after extrusion.. .
|Stabilization of oxidized fats|
A method for improving the palatability of a livestock feed or companion animal food product comprising a basal composition containing unsaturated fatty acids that oxidize to form aldehydes or ketones by contacting the basal composition with a source of bisulfite anions so that any aldehydes or ketones present form organosulfite salts. Bisulfite-treated livestock feed and companion animal food products, and palatability enhancing composition containing a source of bisulfite anions are also disclosed..
|Fermentation of fruit juices|
A method of introducing yeast into a fruit juice such as grape must to be fermented is disclosed. The method comprises feeding dry yeast into a flowing stream of the fruit juice and delivering the flowing stream of fruit juice with the yeast in it to a mixer (10).
|Amino acid-based nutritional formulations|
The present invention relates to an amino acid-based nutritional formulation comprising, per 100 g total amino acids, between about 4.5 and about 5 g glutamate. The ratio of cysteine:methionine is in the range of about 0.9:1 to about 1:1.2.
The invention relates to coating of suppositories containing free unsaturated fatty acid, fatty acid ethyl ester and fatty acid monoglyceride that are susceptible to oxidative degradation. The coating retards oxidative degradation of unsaturated fatty acids and gives the suppository a non-oily and smooth surface.
|Compositions suitable for the topical treatment of fungal infections of the skin and nails|
The present invention relates to pharmaceutical compositions suitable for the topical treatment of fungal infections of the skin and nails, such as tinea pedia and tinea cruris, among others. The active ingredients of the present compositions are low molecular weight organic acids and their salts, many of which are previously known as antifungal agents to some degree but which, when used in combination, produce a synergistic enhancement in antifungal potency such that the combined effect is greater than that when used by the agents alone.
|Down regulation of the gene expression by means of nucleic acid-loaded virus-like particles|
The present invention relates to compositions of virus-like particles for the introduction of rna-interference (rnai-) inducing molecules into eukaryotic cells and methods for the cell type-specific transduction of a plurality of eukaryotic cells with rnai-inducing molecules. The present invention furthermore relates to methods for a diagnosis, prevention and/or treatment of diseases or disease states associated with an increased expression rate of at least one endogenous gene, and/or with the undesired expression of at least one endogenous gene and/or foreign nucleic acids, in particular viral nucleic acids..
|Composition and method to improve blood lipid profiles and reduce low density lipoprotein (ldl) per-oxidation in humans using algae based oils and astaxanthin|
In accordance with a non-limiting example, an algae based oil is used in place of a krill oil to treat low density lipoprotein (ldl) oxidation in humans by administering a therapeutic amount of a dietary supplement composition comprising an algae based oil comprising glycolipids and phospholipids and eicosapentaenoic (epa) fatty acids in combination with astaxanthin derived from haematococcus pluvialis (hp) in an oral dosage form, wherein the astaxanthin derived from haematococcus pluvialis (hp) is 0.1 to 2.7 percent by weight of the algae based oil.. .
|Optimized antibodies that target hm1.24|
The present disclosure describes antibodies that target hm1.24. In various aspects, the antibodies have specific cdr, variable, or full length sequences, have modifications with the parent antibody, or include at least one modification relative to a parent antibody that alters affinity to an fcγr or alters effector function as compared to the parent antibody.
|Amino acid sequences directed against rank-l and polypeptides comprising the same for the treatment of bone diseases and disorders|
The present invention relates to amino acid sequences that are directed against rank-l, as well as to compounds or constructs, and in particular proteins and polypeptides, that comprise or essentially consist of one or more such amino acid sequences. The invention also relates to nucleic acids encoding such amino acid sequences and polypeptides; to methods for preparing such amino acid sequences and polypeptides; to host cells expressing or capable of expressing such amino acid sequences or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such amino acid sequences, polypeptides, nucleic acids and/or host cells; and to uses of such amino acid sequences or polypeptides, nucleic acids, host cells and/or compositions, in particular for prophylactic, therapeutic or diagnostic purposes..
|Methods and compositions for increased transgene expression|
Described herein are methods of expressing nucleic acids in t cells pre-exposed to a co-stimulatory signal and then transduced with adenoviral vectors. In some embodiments, the co-stimulation is provided by anti-cd3 and anti-cd28 antibodies and the adenoviral vector is pseudotyped for t-cell entry.
|Collecting and processing complex macromolecular mixtures|
This document provides methods and materials involved in collecting and processing complex macromolecular mixtures (e.g., stool samples). For example, stool collection devices, buffers for stabilizing nucleic acid and polypeptides present in stool, and kits for using sequence-specific capture probes (e.g., nucleic acid sequences designed to hybridize with particular target nucleic acids) to capture target nucleic acids directly from complex macromolecular mixtures (e.g., stool samples) without the need to perform prior steps to enrich, isolate, or purify the nucleic acid component are provided..
|Functionalized zno or zno alloy films exhibiting high electron mobility|
Functionalized films are provided comprising a film of zno or zno alloy disposed over a supporting substrate and a layer of organic molecules comprising terminal carboxylic acid linkage groups, wherein the organic molecules are bound to a surface of the film of zno or zno alloy via the terminal carboxylic acid linkage groups. Thin film transistors comprising the functionalized films are also provided.
|Automated size selection of nucleic acids|
Apparatus and methods for size selecting nucleic acid molecules having wide range of applications including the production of dna libraries for sequencing technologies. An automated high throughput system for size selection of multiple nucleic acid samples that uses imaging technique to detect the progress of a target fraction and feedback from the imaging to control electrophoresis.
|Method for producing biodiesel|
The present invention relates to a method for producing biodiesel comprising a step of generating fatty acid alkyl ester and glycerol by a transesterification of animal and vegetable oils and fats and fatty acid alcohols in the presence of porous materials. The method is characterized by a high response speed and high fame conversion, and can be performed in a consecutive process.
|Compositions and methods for altering alpha- and beta-tocotrienol content|
Preparation and use of isolated nucleic acids useful in altering the oil phenotype in plants. Isolated nucleic acids and their encoded polypeptides that alter alpha- and beta-tocotrienol content in seeds and oil obtained from the seeds.
Described are mutant luciferases, nucleic acids that encode them, cells and animals expressing them, methods of use thereof, and kits.. .
|Oxidative cleavage of unsaturated carboxylic acids|
Provided are processes for the oxidative cleavage of a double bond in an unsaturated carboxylic acid. The process includes contacting the unsaturated carboxylic acid with a mild oxidizing agent and agitating the unsaturated carboxylic acid and the mild oxidizing agent for a time sufficient to cleave a double bond of the unsaturated carboxylic acid and produce a product comprising an aldehyde.
|Method for the production of fluoromethyl esters of androstan-17 beta carboxylic acids|
Described herein are processes for the preparation of monofluoromethylated organic biologically active compounds, starting from protected intermediates and/or reagents to obtain compounds such as fluticasone propionate and fluticasone furoate, in presence of decarboxylating reagents xef2 and brf3, or using fch2sh as a reagent.. .
|Antimicrobial crosslinked polymers containing biomass derived materials|
Novel, crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels and in antimicrobial compositions..
|Acetylated amino acids as anti-platelet agents, nutritional and vitamin supplements|
This invention relates to pharmaceutical compounds and nutritional supplements that are acetylated derivatives of naturally occurring amino acids and acetylated derivatives of peptides derived from naturally occurring amino acids containing hydroxyl groups. They are as useful as anti-platelet drugs, and as nutritional supplements..
|Method for reducing the occurrence on infection in young children|
The invention pertains to the use of a composition in reducing the number of infections episodes and the occurrence of infections in young children, said composition comprising: (a) long chain polyunsaturated fatty acids, wherein the amount of arachidonic acid is less than 0.06 gram per 100 gram fatty acid; and comprising, per 100 g fatty acids: (i) 0.3-0.6 gram docosahexaenoic acid; (ii) 0.2-0.4 gram eicosapentaenoic acid; and (b) between 1.5 and 2.5 gram indigestible oligosaccharides per 100 kcal, comprising: (i) 1.4-2 gram short-chain galactooligosaccharides; and (ii) 0.1-0.5 gram long-chain fructopolysaccharides.. .
|Cell-permeable peptide inhibitors of the jnk signal transduction pathway|
The present invention refers to protein kinase inhibitors and more specifically to inhibitors of the protein kinase c-jun amino terminal kinase. Additionally, the present invention provides jnk inhibitor sequences, chimeric peptides, nucleic acids encoding same as well as pharmaceutical compositions for treating pathophysiologies associated with jnk signaling..
Disclosed are cleaning solutions. More particularly, non-toxic solutions of base, water, alcohol and detergent, that effectively and surprisingly eliminate contaminating aliphatic acids in aqueous solutions.
|Method and apparatus for nucleic acid analysis|
A convenient method for nucleic acid analysis is provided, which enables 1000 or more types of nucleic acid to be analyzed collectively with high comprehensiveness and with a dynamic range of at least four digits. In particular, provided is a very effective analytical method especially for untranslated rnas and micrornas, of which the types of target nucleic acids is 10000 or lower.