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 Large-scale data center based on a contiguous network patent thumbnailLarge-scale data center based on a contiguous network
A large-scale data center is based on orthogonal connectivity of a distributed single-stage connector, having a large number of disjoint primary switches, to a large number of access nodes and a large number of secondary switches. The secondary switches are coupled to a large number of servers forming a server farm.

 System and  improved reactive power speed-of-response for a wind farm patent thumbnailSystem and improved reactive power speed-of-response for a wind farm
The present subject matter is directed to a system and method for regulating reactive power in a wind farm connected to a power grid so as to improve reactive speed-of-response of the wind farm. The method includes receiving a voltage feedback from the power grid and a voltage reference and calculating a linear voltage error as a function of the voltage feedback and the voltage reference.
General Electric Company


 Flippable electrical connector patent thumbnailFlippable electrical connector
A plug for provision of power includes a housing forming a receiving cavity with two opposite sites in a vertical direction which is compatible with a standard plug connector with twelve contacts on each site and a first and second rows of contacts on the sides while in diagonally symmetrical manner. Each contact includes a contacting section, and a connecting section for directly connecting to a corresponding wire.
Foxconn Interconnect Technology Limited


 Flippable electrical connector patent thumbnailFlippable electrical connector
A plug connector includes an insulative housing with mating slot, contacts disposed in the housing by two sides of the mating slot, and a pair of side arms located by two opposite ends of the mating slot in a horizontal transverse direction. A receptacle connector includes an insulative housing defining a horizontal mating tongue; contacts disposed in the housing with contacting sections exposed upon two opposite surfaces of the mating tongue; and a monolithic horizontal metallic shielding plate disposed and extending substantially fully the mating tongue.
Foxconn Interconnect Technology Limited


 Closure seal for electrical adaptor patent thumbnailClosure seal for electrical adaptor
A closure seal that provides an environmental seal about an electrical cable which includes an upper sealing block adapted to be clamped to a lower sealing block so that the cable is encompassed by the two sealing blocks, each block composed of a resilient deformable material and includes a pair of spaced apart arms disposed within the blocks. Each arm lying on a line that is substantially radial to the cable and being pivoted at the end remote from the cable.
Ampfibian Holdings Pty Ltd


 Flippable electrical connector patent thumbnailFlippable electrical connector
A plug for provision of power includes a housing forming a receiving cavity with two opposite sites in a vertical direction which is compatible with a standard plug connector with twelve contacts on each site and a first and second rows of contacts on the sides while in diagonally symmetrical manner. Each contact includes a contacting section, and a connecting section for directly connecting to a corresponding wire.
Foxconn Interconnect Technology Limited


 Providing internet access through a property monitoring system patent thumbnailProviding internet access through a property monitoring system
Methods and systems, including computer programs encoded on computer storage media, for providing internet access through a control panel of an alarm system, the method including establishing, by a control panel of an alarm system in a property, a first connection to an alarm system monitoring server across a cellular network, determining that a known source of internet within the property is not available, in response to determining that the known source of internet within the property is not available, establishing, by the control panel, a second connection to the internet across the cellular network, providing internet access to one or more devices in the property through the second connection, determining that the known source of internet within the property is available, and in response to determining that the known source of internet within the property is available, terminating, by the control panel, the second connection.. .
Alarm.com Incorporated


 System and  adapting alarms in a wearable medical device patent thumbnailSystem and adapting alarms in a wearable medical device
According to another example, a wearable medical device controller is provided. The device controller includes a memory and a processor coupled to the memory.
Zoll Medical Corporation


 Apparatus,  positioning a cable with a sensor by a rotatable cable assembly patent thumbnailApparatus, positioning a cable with a sensor by a rotatable cable assembly
An apparatus, a system and a method positions a cable extending from an alarm system through a housing to face the cable toward the rear of an electronic device to which the cable is attached. The housing has a sensor assembly that holds a light visible through the sensor assembly to denote an alarm condition.
Sennco Solutions, Inc.


 System and  controlling and sharing online images of merchandise patent thumbnailSystem and controlling and sharing online images of merchandise
A system and method that enable online consumers to create unique user-generated content based on photographs of sought after items, such as retail merchandise. Targeted items may include a myriad of products, including art, furniture, paint, real estate, home decor, medical supplies, healthcare, jewelry, automobiles, etc.
Rycross, Llc D/b/a Seeltfit


Entry, storage and retrieval of medical information from a pharmacy


A system and method includes: a pharmacy server receiving a customer id code to allow a customer wireless access to his medical data file stored on the server; the server receiving adherence confirmation data from the customer and storing the adherence confirmation data into the medical data file to confirm that the customer is taking a prescribed medicine according to directions; and the server receiving additional data from the customer and storing the additional data into the medical data file, whereby the customer is provided with wireless access to enter, edit and retrieve data to and from his medical data file.. .
Wal-mart Stores, Inc.


Method and system for motivating proper prescription drug usage


A system and method includes: a pharmacy server receiving a customer id code to allow a customer wireless access to his medical data file stored on the server; the server receiving compliance determination data to determine whether the customer is taking prescription medicine according to directions; activating a shell script on the wireless device from the server when the compliance determination data indicates that the customer is taking the medicine properly; and de-activating the shell script on the wireless device when the compliance determination data indicates that the customer is not taking the medicine properly, whereby the shell script provides wireless operation of a software application.. .
Wal-mart Stores, Inc.


Optical reflector based on a directional coupler and a coupled optical loop


An optical device includes an optical reflector based on a coupled-loopback optical waveguide. In particular, an input port, an output port and an optical loop in arms of the optical reflector are optically coupled to a directional coupler.
Oracle International Corporation


Generator neutral ground monitoring device utilizing direct current component measurement and analysis


A device and method for detecting and analyzing faults in a generator stator are disclosed. The device and method include measuring a direct current component of a neutral ground current in a generator stator grounding conductor, analyzing the direct current flow and comparing it with other ground fault indicators, and providing diagnosis and recommended actions based on the analysis.
Siemens Energy, Inc.


Sample measuring device


An adapter is attached to each sample storage unit in a rack. Each adapter includes a pair of arms, and these arms include a pair of lower-end structural bodies.
Hitachi, Ltd.


Mechanical part-stream sampler


A mechanical part-stream sampler includes a housing positionable over a conveyor belt from which material is to be sampled. The housing encases one or more cutter arms and adjustable cutters.
Precision Samplers, Inc.


Multi-path interferometeric sensor


A multi-path interferometric sensor for sensing small changes in the refractive index of sensing arms thereof, such as caused by the presence of an analyte or changes in analyte concentration, is disclosed. The sensor includes a single light source, a single detector, and a plurality of interferometers or a single multi-path interferometer.
Octrolix Bv


Concealed carry device for firearms


A device for carrying a handgun in a concealed manner includes a stabilizer key capable of being secured to and/or carried on the handgun. A clip is capable of being secured to apparel of a user.

Accessories attached to firearm magazine


In a first aspect, a mounting system to mount accessories to the magazine or magazine baseplate of a firearm is provided. In a more specific best mode, a handgun forearm brace and recoil suppression support, for example, for target shooting, training, and improved aim is discussed.

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Universal display arm holder


A holder for a display arm includes a body from which extend two bent arms for mounting in a pegboard or slat wall. A tapered slot at the top receives a mounting end of the display arm.
K-international, Inc.


Safety securing apparatus


A safety device for securing a television or similar household item against tipping or rocking. The safety device has a pair of base units and a pair of locking arms.

Systems and methods for validating wind farm performance improvements


The present disclosure is directed to systems and methods for validating wind farm performance improvements so as to optimize wind farm performance. In one embodiment, the method includes operating, via a controller, the wind farm in a first operating mode.
General Electric Company


Hunting blind


A hunting blind having a sheet of fabric hunting blind material and a folding overhead support bracket, the folding overhead support bracket to be attached to a tree, pole or stake, the roof of the hunting blind adapted to be supported by the folding overhead support bracket, the folding overhead support bracket having arms attached at one end thereof to a support so that the arms pivot from the support so that the arms can be folded away from each other to support the roof of the hunting blind but folded towards each other for more convenient transport of the bracket to and from the hunting site.. .

Panel positioning device and associated methods


Various embodiments of panel positioning devices are disclosed herein. In one embodiment, a panel positioning device includes a vise grip handle portion with first and second arms extending therefrom.
Pactool International, Ltd.


Support apparatus


A support apparatus for supporting a load on an inclined surface, the support apparatus includes a pair of base extensions removably engaged to the inclined surface, each base extension having first and second end portions, further included is a support platform that includes a plurality of gap forming spaced apart parallel beams that each have proximal and distal end portions, the proximal end portions have a first pivotal attachment to the first end portions. Also, a pair of arms each having a shoulder portion and a strut portion, the shoulder portions have a second pivotal attachment to the distal portions, wherein the strut portions are removably engagable to the second end portions to operationally lock a selected platform angle to the base extensions.

Adjustable awning to fit different size structures


An apparatus, method, and kit for mounting to the wall of a structure. The apparatus comprises: first and second arms, each arm having an elongated portion and a mounting portion arranged at an angle relative to the elongated portion, the mounting portion defining one or more holes, the elongated portion of the first arm having a first inner surface, the elongated portion of the second arm having a second inner surface, first inner surface opposing the second inner surface; at least a first clamp member operably connected to the first arm and at least a second clamp member operably connected to the second arm; and at least one canopy member having a one end portion clamped between the first inner surface and the at least one clamp member and an opposite end portion clamped between the second inner surface and the at least second clamp member..

Biocatalysts and methods for the synthesis of armodafinil


The present invention relates to non-naturally occurring polypeptides useful for preparing armodafinil, polynucleotides encoding the polypeptides, and methods of using the polypeptides. The non-naturally occurring polypeptides of the present invention are effective in carrying out biocatalytic conversion of the (i) 2-(benzhydrylsulfinyl)acetamide to (−)-2-[(r)-(diphenylmethyl)sulfinyl]acetamide (armodafinil), or (ii) benzhydryl-thioacetic acid to (r)-2-(benzhydrylsulfinyl)acetic acid, which is a pivotal intermediate in the synthesis of armodafinil, in enantiomeric excess..
Codexis, Inc.


Panothenate derivatives for the treatment of neurological disorders


Compounds having the following formula (e): formula e or a pharmaceutically acceptable salt thereof, wherein r, r′, r″, x and n are as defined herein are provided. Methods comprising use of such compounds for the treatment of neurologic disorders, such as pantothenate kinase-associated neurodegeneration, and pharmaceutical compositions containing such compounds, and their use in treatment of neurologic disorders are also provided..
Retrophin, Inc.


Fused dihydro-4h-pyrazolo[5,1-c][1,4]oxazinyl compounds and analogs for treating cns disorders


And pharmaceutically acceptable salts thereof, wherein ring b, a1, a2, r6, w and n1 are defined and described herein; compositions thereof; and methods of use thereof. These compounds are useful for treating a variety of neurological and psychiatric disorders, such as those described herein..

Macrocyclization reactions and intermediates useful in the synthesis of analogs of halichondrin b


The invention provides methods for the synthesis of eribulin or a pharmaceutically acceptable salt thereof (e.g., eribulin mesylate) through a macrocyclization strategy. The macrocyclization strategy of the present invention involves subjecting a non-macrocyclic intermediate to a carbon-carbon bond-forming reaction (e.g., an olefination reaction (e.g., homer-wadsworth-emmons olefination), dieckmann reaction, catalytic ring-closing olefin metathesis, or nozaki-hiyama-kishi reaction) to afford a macrocyclic intermediate.
Eisai R&d Management Co., Ltd.


Opioid ketal compounds and uses thereof


Or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain..

Compounds useful for inhibiting metastasis from cancer and methods using same


The present invention includes compositions that are useful in preventing or treating metastasis in a subject diagnosed with cancer. The present invention also includes methods of preventing or treating metastasis in a subject diagnosed with cancer, wherein the method comprises administering to the subject in need thereof an effective amount of a pharmaceutical formulation comprising at least one pharmaceutically acceptable carrier and at least one cx3cr1 or fractalkine antagonist..
Alliance Discovery, Inc.


(indazol-4-yl) hexahydropyrrolopyrrolones and methods of use


And pharmaceutically acceptable salts, esters, amides, or radiolabelled forms thereof, wherein gar, l1, z1 and z2 are as defined in the specification, are useful in treating conditions or disorders prevented by or ameliorated by voltage-gated sodium channels, e.g., nav 1.7 and/or nav 1.8. Methods for making the compounds are disclosed.

Pyrazolopyrimidone or pyrrolotriazone derivatives, preparing same, and pharmaceutical applications thereof


Pyrazolopyrimidone and pyrrolotriazone derivatives, methods of preparation thereof, and pharmaceutical uses thereof are described. Specifically, pyrazolopyrimidone and pyrrolotriazone derivatives represented by the general formula (i) and pharmaceutically acceptable salts thereof are described.
Jiangsu Hengrui Medicine Co., Ltd.


Hsp90 inhibitors


The disclosure relates to compounds of formulae (ia) and (ib), and pharmaceutically acceptable salts thereof wherein z1, z2, z3, xa, xb, xc, xd, y, x2, and x4 are as defined herein, compositions comprising an effective amount of a compound of formula (ia) and/or (ib), and methods to treat or prevent a condition, such cancer which overexpresses her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a compound of formula (ia) or (ib). The disclosure further relates to compounds of formulae (ia) and (ib) in which x2 is a leaving for introducing a radiolabeled atom, such as 124i or 131i and to methods of using such compounds in the preparation of radiolabeled compounds, particularly for use in imaging..
Sloan-kettering Institute For Cancer Research


7-benzyl-4-(methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5 (1h)-one, salts thereof and methods of using the same in combination therapy


This disclosure relates, at least in part, to a method of treatment. In one embodiment, the method of treatment comprises administering to a subject in need of such treatment a first therapeutic agent including compound (1): (structurally represented) or a pharmaceutically acceptable salt thereof in combination with a second therapeutic agent, wherein the first therapeutic agent and the second therapeutic agent are administered either simultaneously or sequentially..
Prov Pharmaceuticals Inc.


Novel quinazoline derivative


Wherein r1 and r2 represent a hydrogen atom, a halogen atom, or a lower alkyl group optionally having a substituent; z represents a cycloalkyl group having a substituent or a cycloalkenyl group having a substituent; and q represents a bicyclic heteroaryl group optionally having a substituent, or a pharmaceutically acceptable salt thereof. Since the compound has an inhibitory effect on the wnt/β-catenin signaling pathway and exhibits an antitumor effect, it is useful as a medicine..

Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)


The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma, melanoma, multiple myeloma, breast cancer, ewing's sarcoma, osteosarcoma, brain cancer, neuroblastoma, lung cancer), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.


Gdf-8 inhibitors


And pharmaceutically acceptable salts, prodrugs and n-oxides thereof (and solvates and hydrates thereof), wherein r1, z and n are as described herein. In certain embodiments, a compound disclosed herein inhibits gdf8, and can be used to treat disease by blocking gdf8 signaling..

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Heteromaromatic compounds useful for the treatment of prolferative diseases


The present invention provides novel compounds of formula (i) and formula (ii), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Syros Pharmaceuticals, Inc.


Heteroaromatic compounds useful for the treatment of prolferative diseases


The present invention provides novel compounds of formula (i), and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject.
Dana-farber Cancer Institute, Inc.


Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde 10a)


Or a pharmaceutically acceptable salt thereof, wherein r′, r1 through r7 and ar are as defined herein. These compounds are useful as inhibitors of phosphodiesterase 10 (pde10a) which are useful in treating central nervous system diseases such as psychosis and also in treating, for example, obesity, type ii diabetes, metabolic syndrome, glucose intolerance, pain and ophthalmic diseases..

Vitamin c prodrugs and uses thereof


Described herein are vitamin c prodrugs of formula (i), (ii), or (iii), and pharmaceutically acceptable salts thereof. Also provided are pharmaceutical compositions, cosmetic or personal care composition, neutraceutical composition, and medical food composition thereof.
University Of Florida Research Foundation, Inc.223


Compounds for treating prostate cancer


A compound, or a pharmaceutically acceptable salt or ester thereof, having a formula i of: r20—(z)b—(y)c—(r21)a—x—r22-r23 wherein r20 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; z is alkanediyl, substituted alkanediyl, cycloalkanediyl, or substituted cycloalkanediyl; y is s, o, or nr10, wherein r10 is h or alkyl; r21 is alkanediyl, substituted alkanediyl, cycloalkanediyl, substituted cycloalkanediyl, alkadienyl, substituted alkadienyl, alkatrienyl, substituted alkatrienyl; x is —c(=0)- or —s(=0)(=0)-; r22 is a moiety that includes at least one divalent amino radical; r23 is an aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocycloalkyl, substituted heterocycloalkyl, alkoxy, aryloxy, a silyl-containing group, a boryl-containing group, a phosphine-containing group, amino, a thio-containing group, a seleno-containing group, halide, or a nitro-containing group; a is 0 or 1; b is 0 or 1; and c is 0 or 1; provided that if x is —c(=0)- then y is not s.. .
University Of Pittsburgh - Of The Commonwealth Sys Tem Of Higher Education


C6-spiro iminothiadiazine dioxides as bace inhibitors, compositions, and their use


In its many embodiments, the present invention provides certain c5-spiro iminothiadiazine dioxide compounds, including compounds formula (i): (structurally represented) or tautomers thereof, and pharmaceutically acceptable salts of said compounds, wherein r1, r2, r3, x, y, s, ring a, ra, m, -l1-, and rl are as defined herein. The novel compounds of the invention are useful as bace inhibitors and/or for the treatment and prevention of various pathologies related thereto.
Merck Sharp & Dohme Corp.


Substituted isoindoline-1,3-dione derivatives


This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogues of apremilast.
Concert Pharmaceuticals, Inc.


Novel intermediate of tapentadol


The present invention relates to novel carbamate intermediate of formula (ii), process for its preparation and process for its conversion into 3-[(1r,2r)-3-(dimethylamino)-1-ethyl-2-methylpropyl]phenol, tapentadol and its pharmaceutically acceptable salts.. .
Sun Pharma Advanced Research Company


4-aminomethylbenzoic acid derivative


A compound represented by general formula (1), a pharmaceutically acceptable salt thereof or a solvate thereof; wherein ar represents an aryl group, or a 5- or 6-membered heteroaryl group containing a nitrogen atom, an oxygen atom or a sulfur atom; y represents, for example, a hydrogen atom or a c1-c6 alkyl group; a represents a c1-c3 alkylene chain which may be substituted with two c1-c2 alkyl groups; x represents a hydrogen atom or a halogen atom; v represents an oxygen atom or a methylene chain; and r represents a group selected from the formulae below.. .

Composition for fertilizing agricultural land, a producing the composition and the use of said composition


The present invention relates to a composition for fertilizing desert land and making it agricultural, characterized in that it comprises animal excrement, plant waste, bentonite in an amount greater than 10%, essential macronutrients, essential micronutrients, agricultural sulphur, algae and effective microorganisms. The invention will be of use in agriculture, in particular for increasing the yields of soils that are not very fertile, such as deserts which form most of the countries of north africa and the middle east.

Convertible pallet jack with rollers


A pallet jack has a forked platform with rollers embedded in the arms of the fork. The rollers are located at intervals from the front of the arms to the rear.

Clamping apparatus


A lifting and support device comprises a first yoke having a first support arm that defining a first wedge slot above the first support arm and a second yoke pivotally coupled to the first yoke having a second support arm inwardly extending toward and laterally spaced from the first support arm and defining a second wedge slot above the second support arm. The first and second wedge slots are substantially aligned when the first and second yokes are in a closed position.

Line capture devices for unmanned aircraft, and associated systems and methods


Line capture devices for unmanned aircraft, and associated systems and methods are disclosed. A system in accordance with a particular embodiment includes a line capture device body having a line slot with an open end and a closed end.
Insitu, Inc.


Rotor driving system


The embodiments of the present invention disclose a rotor driving system, wherein at least three first actuators can drive a nonrotating lower-rotor swashplate to tilt towards a specific direction by cooperating with each other such that a rotating lower-rotor swashplate, lower tilted-arm pull rods and blade-clamp tilted arms of the lower rotor are all in motion, thereby driving first blade clamping bodies to be twisted relative to a lower rotor hub; at least three second actuators can drive a nonrotating upper-rotor swashplate towards a specific direction by cooperating with each other such that a rotating upper-rotor swashplate, upper-rotor steering rod—l arms, lower upper-rotor steering rods, pull rods, upper upper-rotor steering rods, upper tilted-arm pull rods, blade-clamp tilted arms 42 of the upper rotor are all in motion, thereby driving a second blade clamping body to be twisted relative to an upper rotor hub. Thus, in the solution, the structure of a rotor driving system is simplified, thus solving the problems of a low production efficiency of the process and of inconvenient testing and maintenance..
Shenzhen United Aircraft Technology Co., Ltd.


Brake apparatus


A brake apparatus includes a coupling member configured to couple one end parts of a pair of link arms, an actuator mounted on the coupling member and configured to advance and retract an output member, a lever rotatably coupled to the output member and configured to rotate by advancing and retracting movements of the output member and a booster unit provided on at least one of the one end parts of the pair of link arms and configured to rotate the link arms with supporting portions as fulcrums by boosting a force transmitted by the rotation of the lever.. .
Kyb Corporation


Vehicle integrated jack device


A vehicle integrated jack device provides independent extension of separate jack arms controlled from an interior of a vehicle. The assembly includes a vehicle having a frame and a plurality of wheels coupled to the frame.

Dye sublimation fabric separated elements


A laminate that possesses dye sublimation properties, particularly for use as tagless labels and embellishments for garments, apparel, fabric items and so forth such as sportswear fabrics, clothing and accessories is provided. The laminate includes a dye sublimation ink layer that overlies a substrate in which the dye sublimation ink interacts with the substrate's chemical make-up..
Avery Dennison Corporation


Apparatus and automated layup of composite structures


An apparatus for forming a material layer onto a form tool may include at least one nosepiece configured to laterally sweep a ply carrier onto a form tool contour. The apparatus may include a pair of tension arms configured to support opposing lateral sides of a ply carrier having a material layer mounted to a lower surface thereof.
The Boeing Company


Systems and methods for tracking a path using the null-space


Devices, systems, and methods for providing a desired movement of one or more joints of a manipulator arm having a plurality of joints with redundant degrees of freedom while effecting commanded movement of a distal end effector of the manipulator. Methods include defining a constraint, such as a network of paths, within a joint space defined by the one or more joints and determining a movement of the plurality of joints within a null-space to track the constraints with the one or more joints.
Intuitive Surgical Operations, Inc.


Robot with slaved end effector motion


An apparatus having a drive unit having a first drive axis rotatable about a first axis of rotation and a second drive axis rotatable about a second axis of rotation, the second drive axis being coaxial with and partially within the first drive axis and axially rotatable within the first drive axis. A robot arm has an upper arm connected to the drive unit at the first drive axis, a forearm coupled to the upper arm, the forearm being coupled to the upper arm at a first rotary joint and rotatable about the first rotary joint, the first rotary joint being actuatable by a first band arrangement coupled to the second drive axis, and an end effector coupled to the forearm, the end effector being coupled to the forearm at a second rotary joint and rotatable about the second rotary joint, the second rotary joint being actuatable by a second band arrangement coupled to the first rotary joint.
Persimmon Technologies, Corp.


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Multiple bit hand tool


The disclosure is directed at a multiple bit hand tool which includes a handle portion having a plurality of slats each with grooves on either side, and a body portion including a plurality of flanges each having protrusions, wherein when the handle portion and the body portion are connected by the protrusions and the grooves mate to provide a friction fit handle. The multiple bit hand tool also includes a chuck portion with an improved locking collar for locking the tool bit in place when it is in an extended position.
Retract-a-bit Inc.


Instantaneous gas purge apparatus


An instantaneous gas purge apparatus distributes a flow of a gas, such as an inert gas, directly juxtaposed to a welding seam between two adjacent tubes. The device includes a central hub having radially extending stabilizer arms, mounted inside one of the tubes to be welded.
Senior Ip Gmbh


Exercise device


An exercise device is provided with a frame, two pedals, two first swing arms, two second swing arms, a resistance device, two link rods, two cranks, two limiting rods, and two roller assemblies. Each first swing arm has two ends, in which one end pivotally connects to the frame, and the other connects to one of the two second swing arms.
Dyaco International Inc.


Portable exercise device for resistance exercises


A portable exercise device comprising of a base with a plurality of apertures and at least one resistance member threaded through the apertures and with both ends of the resistance member available for gripping by the user during performance of resistance exercises. A device that is flexible, comfortable, light weight and with ease of use provides multiple strengthening, stretching or physical therapy resistance exercises for the chest, shoulders, back, arms, abdominal and leg muscles.

Conveying blades for a compressible rotor


To provide a simple embodiment of a rotor (2) for a fluid pump which is nevertheless very flexible in handling and compressible, in accordance with the invention a conveying blade is provided having at least two arms (12, 13, 14) and a membrane spanned between them hi the expanded state, wherein the struts each have at least one joint, in particular more than one joint, which enables an angling in a first direction in a first movement and bounds an overelongation beyond an elongation angle of in particular 180 in the opposite second direction. In particular when a plurality of joints (15, 16, 17) are provided at the struts, they, and with them the conveying blades, are particularly flexible for simple compressibility..
Ecp Entwicklungsgesellschaft Mbh


Absorbent article containing a soft and durable backsheet


An absorbent article having an outwardly body-facing surface and an outwardly garment-facing surface is provided. The absorbent article contains a topsheet, backsheet, and an absorbent core positioned between the topsheet and the backsheet.
Kimberly-clark Worldwide, Inc.


Formulations useful in the treatment of proliferative diseases affecting the respiratory tract


The present application provides a pharmaceutical formulation comprising a folate receptor (fr)-targeting antineoplastic substance or composition, wherein the pharmaceutical formulation is configured for administration by inhalation, wherein the fr-targeting antineoplastic substance or composition is comprised in a nanoparticle and wherein the nanoparticles are comprised in microparticles, and its use in the treatment of a proliferative disease affecting at least part of the respiratory tract. The present application further provides a pharmaceutical formulation comprising an antineoplastic agent and a fr-targeting excipient, for use in the treatment of a proliferative disease affecting at least part of the respiratory tract..
Universite Libre De Bruxelles


Multi-responsive targeting drug delivery systems for controlled-release pharmaceutical formulation


The present invention proposes the development of technology in the domain of targeted therapy and local drug delivery to the affected area of the tumor. The invention relates to surface modification nano-/micro-containers (spheres of organic and inorganic polymers), which are sensitive to acidic environment, elevated temperature (t˜41-43° c.), redox potential as well as the application of external applied magnetic field.

Formulations of single domain antigen binding molecules


The invention relates to formulations of single domain antigen binding molecules, e.g., nanobody molecules, in particular formulations of tnf-binding nanobody molecules. The single domain antigen binding molecules can include one or more single binding domains that interact with, e.g., bind to, one or more target proteins.
Ablynx N.v.


Treatment of a neurodegenerative disease or disorder


Provided herein are methods for treating a neurodegenerative disease or disorder, or stroke using a combination of one or more rxr agonist and/or one or more nurr1 agonist and one or more trophic factor, or pharmaceutically acceptable salts thereof. Additionally, compositions comprising of one or more rxr agonist and/or one or more nurr1 agonist and one or more trophic factor, or pharmaceutically acceptable salts thereof for treatment of a neurodegenerative disease or disorder, or stroke are provided..
Acadia Pharmaceuticals Inc.


Mercapto-modified biocompatible macromolecule derivatives with low degree of mercapto-modification and the cross-linked materials and uses thereof


The present invention discloses a mercapto-modified biocompatible macromolecule derivative with a low degree of modification. The mercapto-modified biocompatible macromolecule derivative not only maintains the initial structure, physiological function and biocompatibility as much as possible, but also allows the preparation of the biocompatible macromolecule cross-linked material with a low degree of cross-linking through the effectively chemical cross-linking with the introduced mercapto group.
Bioregen Biomedical (changzhou) Co., Ltd.


Compositions and therapeutic methods for the treatment of complement-associated diseases


The invention comprises methods of modulating the complement cascade in a mammal and for treating and/or preventing diseases and disorders associated with the complement pathway by administering a compound of formula i or formula ii, such as, for example, 2-(4-(2-hydroxyethoxy)-3,5-dimethylphenyl)-5,7-dimethoxyquinazolin-4(3h)-one or a pharmaceutically acceptable salt thereof.. .
Resverlogix Corp.


Combinations


The present invention relates to a method of treating cancer in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1h-pyrazol-5-yl]amino}-4-pyridinyl)amino]-n-(methyloxy)benzamide, or a pharmaceutically acceptable salt thereof, and n-{3-[3-cyclopropyl-5-(2-fluoro-4-iodo-phenylamino)6,8-dimethyl-2,4,7-trioxo-3,4,6,7-tetrahydro-2h-pyrido[4,3-d]pyrimidin-1-yl]phenyl}acetamide, or a pharmaceutically acceptable salt or solvate thereof, to a human in need thereof..
Glaxosmithkline Llc


Substituted pyrimidines for treatment of acute cough, chronic cough and urge to cough


Or a pharmaceutically acceptable salt thereof, wherein r1 and r2 are as defined herein.. .

P13k inhibitor for treatment of respiratory disease


The present invention is directed to compounds and pharmaceutically acceptable salts thereof which are inhibitors of the activity or function of the phosphoinositide 3′oh kinase family (hereinafter pi3k) for use in the treatment or prevention of respiratory infections, the treatment of airway damage, and/or the prevention of airway injury in patients.. .
Glaxosmithkline Intellectual Property Development Limited


Pharmaceutical formulation containing opioid agonist, opioid antagonist and irritant agent


Disclosed in certain embodiments is an oral dosage form comprising: a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and an irritant in an effective amount to impart an irritating sensation to an abuser upon administration of the dosage form after tampering.. .
Purdue Pharma Lp


Aclidinium for use in improving the quality of sleep in respiratory patients


The present disclosure provides aclidinium or any of its stereoisomers or mixture of stereoisomers, or a pharmaceutically acceptable salt or solvate thereof, for improving the quality of sleep in respiratory patients.. .
Almirall, S.a.


Sirt 1 activator including syringaresinol


The present invention relates to a compound of formula 1, and an sirt 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the sirt 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases..
Amorepacific Corporation


Sirt 1 activator including syringaresinol


The present invention relates to a compound of formula 1, and an sirt 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the sirt 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases..
Amorepacific Corporation


Sirt 1 activator including syringaresinol


The present invention relates to a compound of formula 1, and an sirt 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the sirt 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases..
Amorepacific Corporation


Amino alcohol derivatives for the treatment of demyelinating peripheral neuropathies


Wherein x, r1, r2, r3, r4, r5, n, r1a, r2a, r3a, r4a, r5a, r6a, r7a, xa and na are defined herein; or the n-oxide derivatives thereof or prodrugs thereof, or a pharmaceutically acceptable salt, solvate or hydrate thereof. The invention further provides combinations of a compound of formula v or vi with one or more therapeutic agents and pharmaceutical composition thereof..

Composition and treating neurological disease


Disclosed are compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of amantadine. Methods of administering the same are also provided..
Adamas Pharmaceuticals, Inc.


Composition and treating neurological disease


Disclosed are compositions comprising amantadine, or a pharmaceutically acceptable salt thereof, and one or more excipients, wherein at least one of the excipients modifies release of amantadine. Methods of administering the same are also provided..
Adamas Pharmaceuticals, Inc.


Composite formulation comprising tadalafil and amlodipine


A composite formulation is provided which includes: tadalafil or a pharmaceutically acceptable salt thereof as an active ingredient; and amlodipine or a pharmaceutically acceptable salt thereof as an active ingredient, wherein a total amount of tadalafil and amlodipine is in a range of about 6 parts to about 16 parts by weight based on 100 parts by weight of a total weight of the composite formulation.. .
Hanmi Pharm. Co., Ltd.


Sustained release formulation of nalbuphine


Sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; methods for making the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof; and methods for using the sustained release formulations of nalbuphine or pharmaceutically acceptable salts thereof to treat patients suffering from pain are provided.. .
Endo Pharmaceuticals Inc.


Platinum aggregates and process for producing the same


One aspect of the disclosure relates to a new fom1 of lipid-complexed active platinum compound, which allows for high concentrations of platinum compound in the composition. For example, the concentration of cisplatin in the composition is higher at room temperature, e.g., about greater than 1.2 mg/ml, compared to 1 mg/ml in aqueous solution.
Insmed Incorporated






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