|| List of recent Arm-related patents
|Multilayered deception for intrusion detection and prevention|
Concepts and technologies are disclosed herein for multilayered deception for intrusion detection. According to various embodiments of the concepts and technologies disclosed herein, a multilayer deception system includes honey servers, honey files and folders, honey databases, and/or honey computers.
Concepts and technologies are disclosed herein for verifying sender information. According to various embodiments of the concepts and technologies disclosed herein, a verification service can determine, receive a request, or receive a call to verify sender information associated with data.
|Apparatus and method for rewarding consumers|
In order to reward a consumer for trying or learning about a product, the customer is given a unique identification number, preferably an unvalidated atm readable card, and instructions for completing a test or survey by telephone or on the internet. Upon successful completion of the test by the consumer, the identification number is validated so that the consumer may withdraw a cash reward from a temporary bank account funded when the identification number is validated via an atm.
|Pso-guided trust-tech methods for global unconstrained optimization|
A method determines a global optimum of a system defined by a plurality of nonlinear equations. The method includes applying a heuristic methodology to cluster a plurality of particles into at least one group for the plurality of nonlinear equations.
|Method for managing and eliminating float threads in knitted garments|
A method for reducing the occurrence of float threads on the surface of a machine-knitted fabric. Beginning with an initial programmed pattern describing yarn used at each stitch in a knitting pattern, the present method identifies stitches that will create float threads, sorts the identified float threads, giving priority to those float threads that would most limit stretch in a knitted garment, taking into account factors such as float thread length, location in a garment and yarn stretch.
|Percutaneous mitral valve replacement and sealing|
Apparatus is provided for use with a prosthetic valve for implantation at a native valve of a subject, the native valve including at least one native leaflet, the apparatus including (1) a prosthetic valve support, including (a) an upstream support portion, being configured to be placed against an upstream side of the native valve, and having an inner perimeter that defines an opening that is configured to receive the prosthetic valve, and (b) at least one clip (i) comprising at least two clip arms and a clip-controller interface, the clip-controller interface being coupled to at least one of the clip arms, and (ii) being configured to be coupled to a native leaflet of the native valve; and (2) at least one clip controller, reversibly couplable to the clip-controller interface, and configured to facilitate opening and closing of the clip. Other embodiments are also described..
|Controlled tip release stent graft delivery system and method|
An apparatus and method of deploying a stent graft having a proximal anchor stent ring includes restraining proximal apexes of the proximal anchor stent ring between a spindle body of a spindle and a control release sleeve of a tapered tip. The control release sleeve is advanced relative to the spindle to release a first proximal apex through an opening in the control release sleeve while the remaining proximal apexes remain restrained by the control release sleeve.
|Method and apparatus for resecting and replacing an aortic valve|
Apparatus for resecting a diseased heart valve, the apparatus comprising: a body portion; a first handle and a second handle; a cutting blade; a set of retaining arms; a pass-off tool having a first attachment device configured to selectively engage the first handle attached to the body portion so as to allow placement of the second handle of the body portion adjacent to the diseased heart valve, and a controller tool having a second attachment device at the distal end thereof, the second attachment device configured to selectively engage the second handle attached to the body portion so as to allow positioning of the body portion adjacent to the diseased heart valve, a cutting blade actuator configured to cause the cutting blade to selectively rotate, and a retaining arm actuator configured to selectively position the set of retaining arms from the contracted state to the expanded state.. .
A conductive garment. Conductive fabric sections are each separated by a nonconductive strip.
A convective blanket may be converted from an underbody blanket to a combination over body and underbody blanket by having an openable seal positioned substantially orthogonal to the longitudinal axis of the blanket away from the head area of the blanket. The seal may be preformed with a line of weakness so that it may readily be separated to form an opening for the head of the patient.
|Device and method for implanting a spinous process fixation device|
The disclosure provides a device to facilitate the insertion and attachment of an implant that includes a barrel assembly and a plate assembly in an interspinous space. The device comprises a main body, a first arm that is configured to hold the barrel assembly, and a second arm that is configured to hold a locking plate of the plate assembly, wherein the first and second arms are movably attached to the main body..
|Apparatus for intraocular injection|
Described is an apparatus for intraocular injection comprising a body adapted to accommodate a syringe having a needle, an outer sleeve telescopically coupled to the body, and at least two arms hingedly coupled to the outer sleeve. Each of the arms comprises a medial portion adapted to encase at least a portion of the needle.
|Device for prevention of shunt stenosis|
A method and a kit for the prevention of venous stenosis associated with the use of hemodialysis av shunts. The kit may use a bifurcated needle for providing access to the shunt or blood vessel.
|Compression garment with perspiration relief|
A compression garment includes a bladder having an inner surface and an outer surface. Wicking material may be present to wick fluid.
|Subcutaneous cardiac monitoring devices, systems and methods|
An implantable cardiac monitoring device includes first and second arms, pivotably attached to one another; electronic circuitry and an associated power source of the device are hermetically sealed in a housing formed by one of the arms. A first electrode is carried by the first arm, a second electrode by the second arm, and a third electrode by one of the two arms.
|Cable system for generating signals for detecting motion and measuring vital signs|
The invention provides a system and method for measuring vital signs and motion from a patient. The system features: (i) first and second sensors configured to independently generate time-dependent waveforms indicative of one or more contractile properties of the patient's heart; and (ii) at least three motion-detecting sensors positioned on the forearm, upper arm, and a body location other than the forearm or upper arm of the patient.
A retractor for use in surgical operations comprises a pair of blade assemblies which are adapted to open about a set of axes that are not parallel to a third spatial axis. The retractor further comprises a pair of arms, which are adapted to move the pair of blade assemblies apart from one another in the third spatial axis.
|Method of using a surgical tissue retractor|
A method of performing an operation, e.g. A spinal operation, on a patient using a retractor comprising a pair of blade assemblies which are adapted to open about a set of axes that are not parallel to a third spatial axis, and further comprising a pair of arms, which are adapted to move the pair of blade assemblies apart from one another in the third spatial axis.
|Pelvic implant and treatment method|
A unitary or homogeneous patterned implant is provided. The implant is constructed of patterned cells formed by way of a molding, die casting, laser etching, laser cutting, extruding, and the like.
|Implants and procedures for supporting anatomical structures for treating conditions such as pelvic organ prolapse|
Implants for the treatment of pelvic support conditions and methods of implementing the same. The implants comprise relatively soft, flexible bodies and relatively strong arms extending in predetermined orientations therefrom.
|Incontinence implant assembly|
An implant assembly for treating incontinence in a patient may include an implant and an elongated member. The implant may include a first arm, a second arm, and a central portion, the first and second arms extending from the central portion.
Or a pharmaceutically acceptable salt thereof.. .
|Toll-like receptor-7 and -8 modulatory 1h imidazoquinoline derived compounds|
The present disclosure provides novel imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof, and methods of making and using such compounds. The present disclosure also provides tlr7 agonists and tlr7/tlr8 dual agonists, probes, tissue-specific molecules, adjuvants, immunogenic compositions, therapeutic compositions, and self-adjuvanting vaccines including the imidazoquinoline derived compounds, derivatives thereof, analogues thereof, and pharmaceutically acceptable salts thereof.
|Therapeutic agent for blood-brain barrier disruption syndrome|
A medicinal agent or a pharmaceutical composition, each of which comprises a biguanides agent or a pharmaceutically acceptable salt thereof as an active ingredient, and which can potentiate blood-brain barrier functions including tight junction capability and transcellular transport capability of a brain capillary endothelial cell and therefore can treat blood-brain barrier dysfunction syndrome.. .
Or a pharmaceutically acceptable salts thereof; wherein the variables r1-r5, ar1, and x are as defined herein. The compounds are capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation..
|Neuroactive substituted cyclopenta[b]phenanthrenes as modulators for gaba type-a receptors|
The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to gaba function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds..
|Treatment of cancer and other conditions using a transcription factor modulator|
The present disclosure provides novel methods for treating cancer and conditions regulatable by a transcription factor and/or cofactor using specific compounds, as well as compositions, and pharmaceutical formulations. In certain embodiments, the compounds are transcription factor modulators..
|Novel transcription factor modulators|
The present disclosure provides novel compounds capable of functioning as transcription factor modulators, as well as compositions, pharmaceutical formulations, and kits. Also provided are methods of treating a condition regulatable by a transcription factor and/or cofactor using the compounds, compositions, pharmaceutical formulations, and kits provided herein..
|Pharmaceutical compositions that inhibit disproportionation|
Pharmaceutical formulations comprising solid pharmaceutically acceptable organic acids, such as maleic acid or tartaric acid, that inhibit the disproportionation of pharmaceutically acceptable acid salts of active pharmaceutical ingredients, and methods of manufacturing such pharmaceutical compositions. The pharmaceutically acceptable acid salt of the active pharmaceutical ingredient has a pka of less than about 6.0, and wherein the solid pharmaceutically acceptable organic acid has a pka of less than about 4.0 and an aqueous solubility in the range of about 500 to about 2000 milligrams per milliliter.
|Administration of dipeptidyl peptidase inhibitors|
Pharmaceutical compositions comprising 2-[[6-[(3r)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2h)-pyrimidinyl]methyl]-benzonitrile and pharmaceutically acceptable salts thereof in combination with metformin and in combination with pioglitazone.. .
|Piperidinyl-substituted lactams as gpr119 modulators|
Compounds of formula (i) and pharmaceutically acceptable salts thereof in which x1, x2, x3, l, r3, r4, r5, r7 and n have the meanings given in the specification, are modulators of gpr119 and are useful in the treatment or prevention of diseases such as, but not limited to, type 2 diabetes, diabetic complications, symptoms of diabetes, metabolic syndrome, obesity, dyslipidemia, and related conditions.. .
|Method of treatment|
The present invention relates to a method of treating t cell mediated inflammatory immune diseases or t cell mediated hypersensitivity diseases, which comprises administering to a human in need thereof an effective amount of a compound which inhibits ezh2 and/or ezh1, or a pharmaceutically acceptable salt thereof.. .
|Biaryl ether sulfonamides and their use as therapeutic agents|
This invention is directed to biaryl ether sulfonamides, or pharmaceutically acceptable salts, solvates or prodrugs thereof, for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.. .
|Pyridinyl and fused pyridinyl triazolone derivatives|
Or pharmaceutically acceptable salts thereof, wherein r1, r2, r3, and r4 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of formula 1, to pharmaceutical compositions which contain them, and to their use for treating type i hypersensitivity reactions, autoimmune diseases, inflammatory disorders, cancer, non-malignant proliferative disorders, and other conditions associated with btk..
|Fsh receptor antagonists|
The invention relates to fsh receptor antagonist according to general formula i or a pharmaceutically acceptable salt thereof and to a pharmaceutical composition containing the same. The compounds can be used for the treatment and prevention of endometriosis, for the treatment and prevention of pre-menopausal and peri-menopausal hormone-dependent breast cancer, for contraception, and for the treatment of uterine fibroids and other menstrual-related disorders..
|Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors|
The present application relates to cycloalkylpyridin-2-amines derivates of formula (1) or stereoisomers thereof or pharmaceutically acceptable salts thereof. The present application also relates to the process for the preparation of compounds of formula (i).
|Mineralocorticoid receptor antagonists|
The present invention is directed to compounds of the formula (i) as well as pharmaceutically acceptable salts thereof that are aldosterone receptor antagonists which might be useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the formula (i), to their possible use for the treatment of the above-mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the formula (i)..
|Benzoimidazoles as prolyl hydroxylase inhibitors|
And enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof. Compounds of the present invention are useful in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions modulated by prolyl hydroxylase activity..
|Novel oxazine derivatives and their use in the treatment of disease|
The invention relates to novel oxazine derivatives of formula (i), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of alzheimer's disease or diabetes via inhibition of bace-1 or bace-2.. .
|Novel compound having angiogenesis inhibitory activity, method for preparing same, and pharmaceutical composition comprising same|
Disclosed are an anti-angiogenic compound, represented by chemical formula i, or a pharmaceutically acceptable salt thereof, a preparation method thereof, and a pharmaceutically acceptable composition including the same. Because the compound of chemical formula i potently suppresses the angiogenesis, the compound of chemical formula i is applicable to the prevention and treatment of diseases caused by aberrant activity of vascular endothelial growth factor, and available as an anti-angiogenic agent..
Wherein r1, r2, r6, y1, y2, a1, a2, a3, and a4 have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and aids. Also provided are pharmaceutical compositions comprising one or more compounds of formula (i)..
|Heteroaryl sodium channel inhibitors|
The present invention provides compounds of formula i or ii, or pharmaceutically acceptable salts thereof, that are inhibitors of voltage-gated sodium channels, in particular nav 1.7. The compounds are useful for the treatment of diseases treatable by inhibition of channels such as pain disorders.
Wherein r1, r2, a1, a2, a3, a4, x, and y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and aids. Also provided are pharmaceutical compositions comprising one or more compounds of formula (i)..
Where r1-r5 and x are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity.
|Substituted cyclopropyl compounds, compositions containing such compounds and methods of treatment|
Substituted cyclopropyl compounds of the formula i and the pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are useful as agonists of the g-protein coupled receptor gpr-119.
|Cephem derivative having catechol group|
A compound represented by formula (i) or a pharmaceutically acceptable salt thereof wherein a represents a group represented by one of formulae (i)-(iii); b represents a group represented by formula (v) or (vi); and e represents a substituted or unsubstituted heterocyclic group having a cationic nitrogen atom.. .
|Combinations of akt inhibitor compounds and abiraterone, and methods of use|
The invention provides a combination of a) a compound of formula (ia): or a pharmaceutically acceptable salt thereof, and b) abiraterone or a pharmaceutically acceptable salt thereof for the prophylactic or therapeutic treatment of a hyperproliferative disorder, such as cancer.. .
|Combination therapy of hsp90 inhibitors with braf inhibitors|
A pharmaceutical combination comprising a braf inhibitor, and an hsp90 inhibitor according to the following formulae (i): or a tautomer, or a pharmaceutically acceptable salt thereof, wherein the variables are defined therein. Also provided is a method for treating a proliferative disorder in a subject in need thereof, using the pharmaceutical combination described herein..
|Amphotericin analogous compounds and pharmaceutical compositions containing them|
Wherein m is a macrocyclic lactone ring; n is a polyene sugar, substituted or unsubstituted; x is independently selected from o, s, n or nh; r is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.. .
|Discontinuous centrifuge with a scraper for scraping a product|
A discontinuous centrifuge consists of a rotatable centrifuge drum incorporating a drive spindle, a casing and a base. A hub of the centrifuge drum comprises a plurality of arms for the indirect or direct connection of the casing of the centrifuge drum to the drive spindle of the centrifuge drum.
|Muscular evaluation and exercise device|
An apparatus for the development of upper body parts and muscles is disclosed. The apparatus includes a base on which is mounted a seat supported above the base and a forearm pad disposed forward of the seat and supported above the base.
|Compact torque-transmitting gearbox with high reduction ratio|
A harmonic drive has an outer gear, an elliptical follower hub, and an outer chain coupled to the follower hub, and having teeth that mate with the outer gear. Preferred embodiments further include an inner chain disposed such that the follower hub is functionally interposed between the inner and outer chains..
|Control system for medical devices and related methods of use|
A system for controlling a medical device includes a shaft rotatable about a longitudinal axis and a plurality of arms extending radially outwards from the shaft. Each arm includes an inward end positioned near the shaft and an outward end.
|Universal replacement ventilator lid assembly|
A universal kit attaching a universal lid thereof to a rooftop structure includes a plurality of mounts and a pair of hinge arms attached to the interior side of the universal lid, and a pair of braces for pivotally attaching distal ends of the hinge arms to the rooftop structure. Each brace has a face for pivotally engaging the mounting hole of one of the hinge arms.
|System and method for constructing huggable fabric arms|
This disclosure relates to a system and method for constructing huggable fabric arms. Specifically, the huggable fabric arms can comprise a pair of hands comprising a left hand and a right hand, wherein said pair of hands comprises a set of open fingers.
|Playsets with molded shells|
A play set includes a molded shell which includes at least two contoured panels and at least one hinge assembly is provided. The play set may optionally further include a figurine.